Hub : Genes

SLC30A10

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1240	0.0310	5.5e-09	0.130	0.083	0.112	0.108	0.111	1.7e-15	2.3e-10	1.8e-13	4.7e-13	2.0e-13
2	TCGA	Esophageal Carcinoma	0.2480	0.1070	3.3e-03	0.056	0.058	0.028	NA	0.040	7.6e-03	6.6e-03	4.5e-02	NA	2.0e-02
3	TCGA	Prostate Adenocarcinoma	0.0636	0.0242	1.8e-04	0.026	0.032	0.045	NA	0.041	9.5e-04	2.2e-04	1.6e-05	NA	3.9e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.6	1.0	2.5	-0.4	1.6	-0.6
Bipolar Disorder or Schizophrenia	0.2	0.6	1.2	-1.1	0.7	-0.3
Depressed Affect (Nagel 2018)	0.3	0.7	1.1	1.0	-0.5	0.9
Depression (Nagel 2018)	0.4	0.6	1.8	1.3	0.2	-0.1
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	0.3	0.5	-0.6
Neuroticism (Nagel 2018)	0.4	0.9	2.5	1.6	-0.4	0.3
Schizophrenia (2018)	0.2	0.4	1.2	-1.1	-0.4	0.0
Schizophrenia vs Biploar Disorder	0.5	0.7	1.9	0.3	-0.4	1.4
Worry (Nagel 2018)	0.3	0.6	1.3	0.5	0.5	-1.1
Alzheimer’s Disease (in mother)	2.3	2.7	7.3	-0.2	2.7	0.8
Alzheimer’s Disease (in father)	0.6	0.7	1.1	-1.1	-0.5	-0.8
Alzheimer’s Disease (including proxy)	1.0	1.5	3.0	-1.2	1.7	-0.3
Crohns Disease (2017)	1.9	4.1	6.6	-2.3	2.6	-0.8
Irritable Bowel Disease (IBD)	2.3	5.5	8.0	-2.3	2.8	-1.8
Ulcerative Colitis (UC)	1.4	2.5	3.7	-1.2	1.9	-1.6
Major Depression (MDD)	0.8	1.0	1.8	-1.1	1.3	0.1
Reaction Time	0.4	0.8	0.9	-0.9	0.8	0.9
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.8	0.4	-1.7	-0.8
Breast Cancer	0.9	2.2	2.8	1.2	-1.7	1.5
Ovarian Cancer	0.5	0.7	1.2	0.6	-0.7	1.1
Prostate Cancer	0.5	0.7	1.1	0.6	0.8	1.0
Age at First Birth	0.6	0.9	2.0	0.3	0.8	-1.4
Bipolar Disorder (2011)	1.2	1.2	2.2	0.6	1.5	-1.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	0.1	-0.5	-0.2
Coronary Artery Disease (CAD)	0.7	0.8	0.9	1.0	1.0	0.8
Crohns Disease (2012)	0.8	1.4	2.4	-1.3	1.6	0.2
Mean Putamen Volume	2.2	2.5	7.3	0.0	-2.7	-0.5
Fasting Glucose	0.8	0.9	2.5	1.6	-0.3	-0.4
HbA1C	0.4	0.5	1.2	-0.1	-1.1	-0.5
HDL Cholesterol	0.3	0.4	0.9	0.3	-0.5	0.9
LDL Cholesterol	0.2	0.4	0.8	-0.9	-0.4	0.3
Lupus	0.7	1.1	2.2	-0.6	-0.8	-1.5
Neuroticism (2016)	0.8	1.1	2.9	1.7	-0.6	0.1
Primary Biliary Cirrhosis	1.8	2.6	5.2	0.9	-2.3	-1.3
Rheumatoid Arthritis	0.2	0.3	0.6	-0.8	0.3	0.5
Schizophrenia (2014)	0.4	0.9	2.2	-1.5	-0.4	-0.6
Triglycerides	0.8	1.4	2.5	-1.6	0.5	-1.2
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.8	0.9	0.6	-0.0
Ulcerative Colitis	0.1	0.2	0.5	-0.2	-0.2	-0.7
Blood Eosinophil Count	0.4	2.7	5.0	-0.2	-2.2	1.8
Blood Platelet Count	0.2	1.9	5.3	0.6	-2.3	0.3
Blood Red Count	0.7	7.1	10.9	-3.0	3.3	-1.2
Blood White Count	0.1	0.8	1.5	-0.7	-1.2	0.5
Heel T-Score	10.9	86.7	166.4	-12.9	5.5	-8.0
BMI	0.0	0.2	0.5	-0.7	-0.4	-0.3
Height	0.1	1.1	3.1	0.5	-1.8	0.1
Waist Hip Ratio (WHR)	2.7	12.3	19.1	4.2	0.5	4.4
Systolic Blood Pressure	0.1	0.7	1.1	-1.1	0.9	-0.2
Smoking Status	0.6	1.3	1.9	-1.2	0.8	-1.4
Allergy or Eczema	0.6	1.6	3.5	-0.9	0.8	-1.9
Cardiovascular Disease	0.2	0.7	1.3	-0.7	1.1	0.6
Hypothyroidism (self reported)	0.1	0.3	0.8	0.2	-0.9	0.2
Respiratory disease	0.3	0.6	1.0	-1.0	-0.6	-0.6
Type 2 Diabetes (T2D) (2018)	1.0	1.9	4.1	0.9	0.9	2.0
Lung FEV1/FVC ratio	1.3	6.7	19.2	0.5	4.4	-0.8
Lung FVC	1.4	7.1	9.4	-3.1	1.5	-3.1
Neuroticism	0.5	1.2	3.1	1.8	-0.6	-0.0
Chronotype (morning person)	0.5	1.2	3.0	0.8	1.7	-0.1
Hair Pigment	0.0	0.1	0.3	-0.6	-0.1	0.3
Tanning	0.1	0.7	1.3	-1.2	-0.8	0.1
Hand grip strength (left)	0.5	1.4	2.2	-1.5	-0.2	-1.3
Number of treatments/medications taken	0.5	0.9	2.0	-1.4	0.9	-0.1
Average weekly spirits intake	0.4	0.5	1.2	-0.1	-1.1	-0.6
Sensitivity / hurt feelings	0.2	0.3	0.9	0.9	0.0	0.4
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.4	1.6	0.2	0.1
Hearing difficulty/problems: Yes	4.0	6.1	9.4	-2.9	-0.6	-3.1
Relative age of first facial hair	0.8	1.7	2.3	1.5	-1.5	-0.7
Other serious medical condition/disability diagnosed by doctor	3.7	4.8	8.7	-1.8	1.5	-3.0
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.9	-0.1	-0.9	0.4
Ever had hysterectomy (womb removed)	1.4	1.6	3.5	1.1	0.2	1.9
Systolic blood pressure, automated reading	0.1	0.2	0.6	-0.8	0.3	-0.1
Eye problems/disorders: Diabetes related eye disease	2.6	2.9	5.9	1.4	-0.8	2.4
Angina	3.6	4.8	10.6	-1.8	3.3	-0.5
Medication for hormone replacement therapy	2.0	2.2	3.6	-1.5	-1.9	-0.8
Vitamin and mineral supplements	1.2	1.6	2.4	0.7	-1.6	1.4
Supplements: Zinc	1.9	2.0	4.9	-0.5	2.2	-1.0
Medication: Co-codamol	0.6	0.6	0.9	0.8	0.9	0.7
Medication: Metformin	1.5	2.1	3.4	1.7	0.1	1.8
Diabetes (father)	0.8	1.0	1.7	-1.2	1.3	-0.2
Diabetes (mother)	0.6	0.7	0.9	0.9	-0.9	0.7
Severe depression (siblings)	0.5	0.5	0.9	-0.9	-0.0	-0.8
Pack years adult smoking proportion	1.2	1.8	3.2	1.4	-0.5	1.8
Impedance of leg (right)	0.8	4.1	10.8	1.2	-3.3	0.4
Leg fat-free mass (left)	0.1	0.4	0.6	-0.7	0.8	-0.2
Trunk fat percentage	1.4	5.7	16.6	-0.6	-4.1	-0.4
Hand grip strength (right)	0.2	0.6	1.3	-0.7	0.1	-1.1
Townsend deprivation index at recruitment	0.7	1.0	2.6	-0.4	-1.6	0.6
Current tobacco smoking	0.3	0.4	1.2	0.0	-1.1	-0.4
Average weekly fortified wine intake	1.1	1.3	2.7	-0.5	1.6	-1.0
Maternal smoking around birth	1.9	2.7	4.0	1.6	-1.3	2.0
Fed-up feelings	0.2	0.3	0.6	0.8	-0.1	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.1	0.3	-0.2	-0.1
Relative age voice broke	0.2	0.3	0.5	0.6	-0.7	0.2
Taking other prescription medications	1.0	1.5	2.5	-1.6	1.3	-0.5
Age when periods started (menarche)	0.1	0.3	0.4	-0.6	-0.3	-0.6
Bilateral oophorectomy (both ovaries removed)	1.9	2.2	6.5	-0.4	-2.5	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	9.1	20.7	36.8	-6.1	3.7	-3.4
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.5	-0.6	-0.7	0.4
Qualifications: CSEs or equivalent	1.2	1.5	2.2	-1.2	1.5	-1.0
Serious illness, injury or assault to yourself	1.0	1.2	2.2	-1.1	-0.4	-1.5
High blood pressure	0.5	1.5	2.6	-1.6	1.3	-0.2
Hayfever, allergic rhinitis or eczema	0.6	1.4	2.2	-0.8	1.1	-1.5
Multivitamins +/- minerals	1.2	1.6	2.3	-1.2	1.0	-1.5
Stomach or abdominal pain in last month	0.4	0.5	0.8	0.5	0.9	-0.6
Supplements: Glucosamine	0.8	1.0	2.5	0.2	1.6	0.7
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	2.4	0.1	1.5	-0.4
Medication: Atenolol	0.6	0.7	1.6	1.3	0.5	0.5
Medication: Levothyroxine sodium	0.2	0.4	0.6	-0.8	-0.5	-0.5
Sitting height	0.1	0.4	0.6	-0.6	0.5	-0.8
Chronic bronchitis/emphysema (father)	1.2	1.5	2.0	1.1	-1.4	1.1
High blood pressure (mother)	1.5	2.1	4.6	-1.0	0.9	-2.1
Body mass index (BMI)	0.2	0.7	1.1	-0.5	-1.1	0.8
Impedance of leg (left)	1.2	5.9	14.4	1.6	-3.8	0.8
Leg predicted mass (left)	0.1	0.4	0.6	-0.8	0.8	-0.2
Trunk fat mass	0.7	3.1	9.2	-0.4	-3.0	-0.1
Waist circumference	0.6	2.3	2.7	1.4	-1.6	1.6
Number of incorrect matches in round	1.2	2.0	4.8	0.4	1.0	2.2
Past tobacco smoking	0.2	0.3	1.0	-0.0	-1.0	0.0
Alcohol usually taken with meals	0.2	0.3	0.3	-0.5	0.5	-0.5
Nervous feelings	0.0	0.0	0.0	0.1	0.1	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.1	1.0	-0.8	-0.5
Hearing difficulty/problems with background noise	2.8	4.5	8.9	-2.1	-0.1	-3.0
Hair/balding pattern: Pattern 2	0.0	0.0	0.0	-0.0	-0.0	0.1
Had menopause	0.2	0.3	0.6	0.5	-0.8	-0.2
Had other major operations	0.2	0.2	0.7	0.0	-0.1	0.8
Forced vital capacity (FVC)	0.1	0.5	1.0	-0.4	-0.6	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	7.8	17.9	34.3	-5.9	3.3	-2.9
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	1.9	-0.9	0.8	-1.4
Qualifications: None of the above	1.3	2.8	7.6	0.9	-0.3	2.8
Financial difficulties in last 2 years	0.4	0.5	1.4	0.2	-1.2	0.1
Mouth/teeth dental problems	0.4	0.6	1.5	-0.4	-1.2	-0.4
Heart attack	0.1	0.2	0.3	0.6	0.1	0.4
Allergy	0.5	1.2	3.0	0.7	-0.3	1.7
Pain all over the body in last month	0.2	0.3	0.6	-0.4	-0.1	0.8
Diabetes (self-reported)	0.4	0.6	1.3	0.6	0.4	1.1
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	2.1	1.4	0.7	1.4
Medication: Ramipril	1.7	2.2	5.1	1.0	0.7	2.3
Medication: Simvastatin	0.3	0.4	0.7	0.0	-0.6	0.9
Fluid intelligence score	0.6	1.2	3.1	-0.6	0.1	-1.8
Illnesses of siblings	0.5	0.7	1.6	0.2	-1.3	0.6
Neuroticism score	0.1	0.3	0.7	0.8	0.2	0.1
Weight	0.1	0.6	1.5	-0.0	-1.2	0.6
Impedance of arm (right)	1.4	6.5	14.2	-0.9	-3.8	-2.1
Arm fat percentage (right)	0.8	3.3	8.5	-1.2	-2.9	-0.1
Trunk fat-free mass	0.3	1.8	3.2	0.9	1.8	1.1
Hip circumference	0.9	3.9	10.6	-0.6	-3.2	-0.9
Time employed in main current job	0.3	0.3	0.8	-0.1	-0.2	-0.9
Alcohol intake versus 10 years previously	0.4	0.5	0.9	-0.5	0.7	-0.9
Father’s age at death	1.3	1.8	2.7	-0.6	1.6	-1.5
Worrier / anxious feelings	0.2	0.4	1.0	1.0	0.4	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.3	-1.2	0.7	0.2
Falls in the last year	1.8	2.5	2.9	1.4	-1.7	1.6
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	0.3	0.2	-0.7
Number of live births	0.5	0.7	1.1	-1.1	-0.8	-0.6
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.9	-0.9	0.6	-1.7
Pulse rate	0.8	1.3	2.1	-1.4	-0.2	-1.4
Happiness	0.4	0.5	1.1	1.0	-0.6	-0.1
Noisy workplace	0.2	0.3	0.5	0.3	-0.7	-0.5
Qualifications: A levels/AS levels or equivalent	0.5	1.2	2.4	0.9	-0.6	-1.6
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.4	1.2	0.8	0.2
Mouth/teeth dental problems: Dentures	0.6	1.1	2.0	0.4	1.4	1.1
Asthma	0.2	0.3	0.8	-0.5	-0.9	0.0
Medication: Ibuprofen (e.g. Nurofen)	2.3	2.9	5.7	-1.7	2.4	-0.0
Medication: Cholesterol lowering	0.1	0.1	0.3	0.5	-0.0	-0.0
Depression (self-reported)	0.4	0.5	0.9	-0.4	1.0	-0.7
Medication: Lansoprazole	1.3	1.4	3.4	0.9	-1.8	0.4
Prospective memory result	0.9	1.1	2.5	0.3	1.6	-0.8
Lung cancer (father)	1.7	2.0	5.4	0.8	-0.1	2.3
Illnesses of mother	0.4	0.5	1.4	0.2	-1.2	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	2.9	-1.1	1.0	-1.7
Pulse wave Arterial Stiffness index	0.8	1.0	2.4	1.5	0.1	0.7
Impedance of arm (left)	1.5	6.7	14.4	-0.8	-3.8	-2.3
Arm fat mass (right)	0.4	1.8	4.8	-0.5	-2.2	0.5
Trunk predicted mass	0.3	1.6	3.0	0.8	1.7	1.0
Standing height	0.0	0.4	0.7	0.9	-0.5	-0.4
Length of working week for main job	0.5	0.6	1.3	0.2	-0.6	1.1
Exposure to tobacco smoke at home	0.5	0.6	1.0	-0.1	0.9	1.0
Breastfed as a baby	3.7	4.5	12.3	3.5	0.1	-1.2
Tense / ‘highly strung’	0.1	0.2	0.4	0.6	0.3	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	3.2	-1.8	0.8	-1.1
Hair/balding pattern: Pattern 4	2.1	5.0	14.3	-0.1	3.8	0.9
Birth weight of first child	0.9	1.7	4.3	-0.6	-2.1	-0.5
Peak expiratory flow (PEF)	0.7	1.7	3.4	-1.0	0.8	-1.9
Pulse wave reflection index	1.7	2.1	3.7	1.3	-1.0	1.9
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.6	0.3	-0.8	0.5
Loud music exposure frequency	0.6	0.6	1.0	-0.6	-0.7	-1.0
Qualifications: O levels/GCSEs or equivalent	1.6	2.6	6.8	-1.0	-0.2	-2.6
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.8	1.4	-0.4	0.2
Blood clot in the leg (DVT)	0.0	0.0	0.1	0.3	-0.1	-0.2
Medication: Paracetamol	0.5	0.9	1.2	-1.1	0.9	-0.8
Headache pain in last month	0.1	0.3	0.6	0.3	-0.1	0.8
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.2	0.1	0.5	-0.2
Glaucoma (self-reported)	1.2	1.4	2.7	-1.0	0.7	-1.6
Gout (self-reported)	1.1	1.5	1.9	-1.4	1.2	-1.0
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	-0.6	-0.3	-0.2
Medication: Amlodipine	0.6	0.8	1.5	-1.2	-0.9	0.0
Medication: Ventolin 100micrograms inhaler	0.5	0.7	0.9	-0.9	-0.4	-0.9
Birth weight	0.1	0.2	0.6	0.8	-0.2	-0.1
Chronic bronchitis/emphysema (mother)	3.2	3.8	6.5	0.9	-2.0	2.6
High blood pressure (siblings)	0.5	0.8	0.9	-0.8	0.9	-0.9
Forced vital capacity (FVC), Best measure	0.3	1.2	2.3	-1.1	0.2	-1.5
Body fat percentage	1.2	4.5	13.2	-0.7	-3.6	-0.2
Leg fat percentage (right)	0.7	2.5	6.9	-0.6	-2.6	0.5
Arm fat-free mass (right)	0.3	1.3	2.0	0.7	1.4	1.2
Exposure to tobacco smoke outside home	1.6	2.2	4.5	-2.1	0.3	-1.4
Comparative body size at age 10	1.1	3.0	4.6	-1.2	2.1	-1.7
Number of full brothers	0.3	0.3	0.9	0.9	-0.4	-0.1
Worry too long after embarrassment	0.3	0.5	1.1	1.0	0.7	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.1	-0.3	-0.1	-0.2
Wheeze or whistling in the chest in last year	0.2	0.3	0.9	-0.2	0.9	0.3
Number of children fathered	1.7	1.9	3.5	1.3	1.9	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.9	0.4	-1.0	0.4
Age at first live birth	1.4	2.5	3.4	1.8	-1.4	-1.5
Pulse wave peak to peak time	0.8	0.9	2.3	-1.5	0.0	-0.7
Health satisfaction	0.3	0.4	1.0	0.2	0.1	-1.0
Shortness of breath walking on level ground	0.3	0.3	0.8	-0.3	-0.9	-0.1
Qualifications: College or University degree	0.5	1.7	2.8	0.7	-1.3	-1.7
Eye problems/disorders: None of the above	0.6	0.8	1.9	-0.2	-1.4	-0.5
Mouth/teeth dental problems: Loose teeth	1.8	2.1	5.6	-0.8	2.4	-0.2
Emphysema/chronic bronchitis	0.1	0.1	0.4	0.2	-0.2	-0.6
Medication for pain relief, constipation, heartburn	0.4	0.6	1.0	0.9	-1.0	-0.1
Neck or shoulder pain in last month	0.6	0.8	2.0	-0.1	1.4	0.6
Medication: Blood pressure	0.3	0.5	1.1	-1.0	-0.7	-0.1
Angina (self-reported)	3.6	4.7	9.1	-2.0	3.0	-0.9
Migraine (self-reported)	0.7	0.8	2.2	1.5	-0.5	0.4
Medication: Ibuprofen	2.6	3.2	5.9	-1.9	2.4	0.2
Medication: Allopurinol	0.8	1.1	3.0	0.0	1.7	0.4
Medication: Omeprazole	0.0	0.0	0.1	-0.1	-0.3	0.1
Medication: Seretide 50 evohaler	1.1	1.3	2.6	-1.6	0.7	-0.8
Mean time to correctly identify matches	0.3	0.7	1.0	-0.6	0.7	1.0
Heart disease (mother)	0.2	0.3	0.7	-0.1	0.9	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	3.3	1.8	-1.1	0.8
Whole body fat mass	0.6	2.4	7.0	-0.3	-2.6	0.4
Leg fat mass (right)	0.4	1.5	3.9	-0.6	-2.0	0.5
Arm predicted mass (right)	0.3	1.5	1.9	0.9	1.3	1.4
Pulse rate, automated reading	0.1	0.2	0.5	-0.7	-0.2	-0.4
Alcohol intake frequency.	0.9	2.1	4.5	0.9	1.0	2.1
Comparative height size at age 10	0.1	0.3	0.8	-0.9	-0.2	-0.2
Number of full sisters	0.8	1.0	1.6	-1.3	0.6	-1.0
Suffer from ‘nerves’	0.3	0.4	0.8	-0.6	0.9	0.2
Overall health rating	0.2	0.5	0.8	-0.6	0.4	-0.9
Chest pain or discomfort	0.4	0.6	0.8	-0.6	0.9	-0.7
Had major operations	0.1	0.1	0.2	-0.5	-0.2	-0.0
Age at last live birth	1.0	1.4	2.9	0.4	-1.1	-1.7
Family relationship satisfaction	2.6	3.2	6.2	-1.8	0.1	-2.5
Leg pain on walking	0.9	1.1	1.8	1.1	-1.3	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.5	-1.0	1.2	0.0
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.5	-0.9	-1.2	-0.8
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	3.1	-1.5	0.3	-1.8
Medication: Aspirin	0.3	0.4	0.7	0.8	0.8	0.1
Supplements: Vitamin C	1.1	1.3	2.3	-1.0	1.5	-0.7
Knee pain experienced in last month	0.5	0.7	1.1	0.2	1.1	-1.0
Hypertension (Self-reported)	0.5	1.5	3.2	-1.8	1.1	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	1.9	-1.2	-0.2	-1.4
Illnesses of father: Heart disease	0.2	0.3	0.8	0.1	-0.4	-0.9
Illnesses of siblings: Diabetes	0.5	0.6	1.7	0.4	1.3	-0.1
Smoking status: Previous	1.0	1.5	2.9	-1.0	1.7	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.0	1.0	0.5	-0.4
Whole body fat-free mass	0.2	0.9	2.0	0.4	1.4	0.7
Leg fat-free mass (right)	0.1	0.4	0.9	-0.4	0.9	0.0
Arm fat percentage (left)	0.8	3.2	8.1	-1.2	-2.8	-0.3
Average weekly red wine intake	0.4	0.6	1.1	0.8	1.1	0.1
Handedness (chirality/laterality): Left-handed	1.2	1.5	2.0	-0.7	1.4	-1.4
Mood swings	0.2	0.4	1.1	0.4	-0.1	1.0
Loneliness, isolation	0.1	0.1	0.2	-0.2	0.5	-0.4
Long-standing illness, disability or infirmity	0.5	0.7	0.9	-0.9	-1.0	-0.6
Ever had bowel cancer screening	0.1	0.1	0.2	-0.3	-0.0	-0.4
Diabetes diagnosed by doctor	1.3	2.1	5.0	1.2	-0.1	2.2
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	3.0	-0.3	1.0	-1.7
Friendships satisfaction	1.2	1.5	2.7	-0.6	1.6	-1.3
Qualifications: nursing, teaching	1.8	2.8	4.7	-0.3	-1.9	-2.2
Commuting to job workplace: Walk	0.5	0.6	0.7	0.7	0.8	0.7
Eye problems/disorders: Cataract	0.0	0.0	0.0	-0.0	0.1	0.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.4	0.0	0.6	0.2
Medication for cholesterol	0.2	0.4	0.6	0.8	-0.4	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.1	1.4	-0.5	0.3
Back pain experienced in last month	0.3	0.4	1.0	0.2	-1.0	0.4
Mineral and other dietary supplements	1.4	1.9	4.2	0.0	-2.1	1.2
Breast cancer (self-reported)	0.0	0.0	0.1	-0.2	0.1	-0.3
Asthma (self-reported)	0.3	0.5	1.2	-0.6	-1.1	0.0
Osteoporosis (self-reported)	0.9	1.1	2.7	0.3	-1.6	-0.6
Osteoarthritis (self-reported)	0.1	0.1	0.2	0.1	-0.2	0.5
Medication: Aspirin	0.3	0.4	1.1	0.2	1.0	-0.2
Medication: Gliclazide	0.8	0.9	1.8	0.6	0.7	1.3
Illnesses of father: None of the above (group 1)	0.9	1.1	2.3	1.0	0.1	1.5
Smoking status: Current	0.3	0.4	1.1	0.3	-1.1	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.6	3.0	-1.7	-0.1	-1.3
Whole body water mass	0.2	0.9	2.0	0.4	1.4	0.8
Leg predicted mass (right)	0.1	0.4	0.9	-0.5	1.0	-0.1
Arm fat mass (left)	0.4	1.6	4.3	-0.7	-2.1	0.4
Number of self-reported non-cancer illnesses	0.1	0.1	0.3	-0.3	0.6	-0.0
Average weekly champagne plus white wine intake	0.4	0.6	1.6	0.0	0.4	-1.3
Miserableness	0.8	1.4	3.5	0.4	-0.8	1.9
Guilty feelings	1.3	2.0	4.0	2.0	-1.0	0.9
Wears glasses or contact lenses	1.5	1.7	2.1	1.4	-1.3	1.1
Ever taken oral contraceptive pill	0.2	0.3	0.4	0.6	-0.1	0.6
Hearing aid user	2.6	2.9	5.9	-2.4	1.2	-1.2
Mother’s age at death	0.3	0.4	0.9	0.4	0.3	1.0
Financial situation satisfaction	0.1	0.1	0.2	-0.4	-0.3	-0.5
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.3	-0.4	-1.1	-0.9
Commuting to job workplace: Public transport	2.2	2.7	5.2	1.6	0.6	2.3
Eye problems/disorders: Glaucoma	0.7	0.8	1.6	-0.9	0.0	-1.3
Medication: Blood pressure	0.2	0.3	0.6	-0.5	0.8	0.3
Pain type(s) experienced in last month: Hip pain	1.8	2.3	6.6	0.2	-2.6	-0.4
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.9	-0.2	0.9	-0.8
High cholesterol (Self-reported)	0.4	0.7	2.1	1.5	0.1	-0.1
Medication: Bendroflumethiazide	1.4	2.1	3.1	-1.2	1.4	-1.8
Medication: Paracetamol	0.4	0.6	1.4	-1.2	0.3	-0.4
Medication: Lisinopril	0.7	0.9	1.5	-1.2	1.1	-0.1
Medication: Atorvastatin	0.6	0.7	1.4	0.8	0.3	1.2
Illnesses of father: High blood pressure	0.4	0.5	0.7	-0.8	0.7	-0.6
Alcohol drinker status: Never	3.0	3.6	7.8	1.7	-0.2	2.8
Ever smoked	0.2	0.3	0.5	0.7	0.4	-0.4
Basal metabolic rate	0.1	0.4	0.6	0.2	0.8	0.8
Leg fat percentage (left)	0.8	2.9	7.8	-0.3	-2.8	0.9
Arm fat-free mass (left)	0.2	1.2	2.2	0.9	0.8	1.5
Number of operations (self-reported)	0.5	0.7	1.2	-1.1	0.9	-0.3
Average weekly beer plus cider intake	0.2	0.3	0.5	0.7	0.5	-0.4
Irritability	0.9	1.4	2.2	1.2	-0.8	1.5
Risk taking	0.6	0.9	1.6	0.2	-1.3	-1.0
Ever had prostate specific antigen (PSA) test	1.4	1.6	4.1	-2.0	-0.6	-0.6
Fractured/broken bones in last 5 years	0.6	0.8	1.5	-0.5	-0.9	-1.2
Age started oral contraceptive pill	0.4	0.5	1.0	0.6	1.0	0.2
Diastolic blood pressure, automated reading	0.4	1.1	3.2	-0.3	-1.8	-0.1
Ever depressed for a whole week	3.5	4.3	6.2	-2.5	2.0	-1.6
Unable to work because of sickness or disability	1.1	1.4	2.6	1.1	-0.6	1.6
Commuting to job workplace: Cycle	0.6	0.7	1.5	-0.1	-0.8	1.2
Myopia	1.0	1.5	1.8	1.4	-1.0	-1.3
Vascular/heart problems diagnosed by doctor	0.7	1.8	2.8	1.7	-1.6	-0.3
Cholesterol lowering medication	0.7	1.0	2.7	0.5	0.1	1.6
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.0	0.2	-0.1	0.1
Pain experienced in last month	0.3	0.5	1.3	0.3	0.1	-1.2
Supplements: Calcium	1.9	2.0	4.2	-0.2	2.1	-1.4
Basal cell carcinoma (self-reported)	0.0	0.0	0.1	0.1	0.1	-0.2
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.4	0.6	0.3	0.6
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.4	-0.1	-0.4
Heart disease (siblings)	0.8	1.0	1.4	-1.1	0.6	-1.2
Alcohol drinker status: Previous	0.2	0.2	0.4	0.5	0.6	0.2
Pack years of smoking	1.2	1.7	2.8	1.6	-0.2	1.7
Impedance of whole body	1.2	5.9	16.7	0.5	-4.1	-0.9
Leg fat mass (left)	0.5	1.8	4.7	-0.4	-2.2	0.7
Arm predicted mass (left)	0.3	1.8	3.2	1.2	0.8	1.8