Hub : Genes

COPS3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0610	0.0300	7.6e-03	0.037	0.010	0.013	0.018	0.027	2.5e-05	1.9e-02	9.5e-03	2.7e-03	2.4e-04
2	GTEx	Whole Blood	0.1440	0.0360	5.8e-10	0.173	NA	0.157	NA	0.160	8.7e-16	NA	2.4e-14	NA	1.3e-14
3	NTR	Blood	0.0306	0.0104	1.3e-05	0.028	0.021	0.020	0.023	0.025	1.7e-09	1.9e-07	2.9e-07	3.4e-08	1.4e-08
4	YFS	Blood	0.1688	0.0270	0.0e+00	0.216	0.186	0.213	0.210	0.216	5.9e-69	2.0e-58	6.0e-68	6.3e-67	8.3e-69

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.0	0.0	0.1	0.2	0.0	-0.3	-0.1
Bipolar Disorder or Schizophrenia	0.6	1.6	2.2	-1.2	1.5	1.1	1.2
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	0.6	-0.4	-0.5	-0.3
Depression (Nagel 2018)	0.8	1.3	1.3	1.1	-1.1	-1.1	-1.1
Intelligence (Savage-Jansen 2018)	0.7	2.2	2.6	-1.6	1.6	1.5	1.3
Neuroticism (Nagel 2018)	1.4	3.4	3.8	2.0	-1.9	-1.8	-1.7
Schizophrenia (2018)	1.4	3.0	3.5	-1.7	1.9	1.6	1.7
Schizophrenia vs Biploar Disorder	1.4	1.8	1.9	-1.4	1.4	1.3	1.2
Worry (Nagel 2018)	0.8	1.6	1.8	1.3	-1.3	-1.2	-1.2
Alzheimer’s Disease (in mother)	0.4	0.4	0.6	-0.8	0.5	0.7	0.6
Alzheimer’s Disease (in father)	1.7	1.8	2.1	1.5	-1.2	-1.4	-1.4
Alzheimer’s Disease (including proxy)	0.2	0.3	0.3	0.6	-0.4	-0.5	-0.5
Crohns Disease (2017)	1.1	2.4	3.0	1.7	-1.4	-1.5	-1.6
Irritable Bowel Disease (IBD)	1.1	2.6	3.2	1.8	-1.6	-1.5	-1.5
Ulcerative Colitis (UC)	0.9	1.8	2.1	1.4	-1.4	-1.2	-1.2
Major Depression (MDD)	1.3	1.6	1.8	-1.2	1.2	1.2	1.4
Reaction Time	0.1	0.3	0.4	-0.5	0.4	0.6	0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.5	-0.7	0.7	0.6	0.4
Breast Cancer	0.6	1.5	2.0	1.0	-1.4	-1.2	-1.2
Ovarian Cancer	2.3	3.0	3.6	1.7	-1.9	-1.6	-1.7
Prostate Cancer	0.3	0.5	0.5	0.7	-0.6	-0.7	-0.7
Age at First Birth	2.2	3.3	3.6	1.6	-1.9	-1.8	-1.9
Bipolar Disorder (2011)	0.0	0.0	0.0	-0.1	0.0	0.0	0.2
Body Mass Index (BMI) (2010)	0.2	0.2	0.4	-0.4	0.6	0.4	0.4
Coronary Artery Disease (CAD)	0.3	0.4	0.5	-0.4	0.7	0.7	0.7
Crohns Disease (2012)	2.4	3.8	4.2	2.1	-1.9	-2.0	-1.9
Mean Putamen Volume	1.1	1.2	1.7	1.3	-1.0	-1.1	-1.0
Fasting Glucose	0.0	0.0	0.0	0.1	-0.2	-0.1	0.0
HbA1C	0.0	0.0	0.0	-0.1	-0.1	0.1	0.2
HDL Cholesterol	0.5	0.8	1.0	0.9	-0.9	-0.9	-1.0
LDL Cholesterol	1.2	2.0	2.3	-1.5	1.4	1.3	1.4
Lupus	0.2	0.3	0.5	-0.6	0.4	0.7	0.4
Neuroticism (2016)	1.3	1.9	2.1	1.4	-1.4	-1.3	-1.4
Primary Biliary Cirrhosis	0.1	0.1	0.3	-0.1	0.5	0.3	0.2
Rheumatoid Arthritis	0.0	0.0	0.0	0.0	0.0	0.1	0.1
Schizophrenia (2014)	0.6	1.4	2.1	-1.1	1.4	1.1	1.0
Triglycerides	0.0	0.0	0.1	0.2	-0.2	-0.0	-0.2
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	0.4	-0.3	-0.2	-0.5
Ulcerative Colitis	0.9	1.3	1.6	1.3	-1.2	-1.0	-1.0
Blood Eosinophil Count	0.2	1.7	2.0	1.4	-1.1	-1.3	-1.3
Blood Platelet Count	2.1	23.9	26.7	4.7	-5.2	-4.8	-4.8
Blood Red Count	0.1	0.5	0.8	-0.9	0.5	0.8	0.4
Blood White Count	0.0	0.0	0.0	0.1	-0.2	-0.0	-0.1
Heel T-Score	6.9	54.8	57.8	7.5	-6.9	-7.6	-7.6
BMI	0.2	1.4	1.6	1.1	-1.2	-1.1	-1.3
Height	0.7	12.7	13.5	-3.5	3.5	3.7	3.6
Waist Hip Ratio (WHR)	1.0	4.4	4.8	-1.9	2.1	2.2	2.2
Systolic Blood Pressure	0.4	2.2	2.8	1.6	-1.7	-1.4	-1.3
Smoking Status	0.3	0.7	1.1	0.8	-1.0	-0.7	-0.6
Allergy or Eczema	0.3	0.7	0.9	0.8	-1.0	-0.8	-0.7
Cardiovascular Disease	0.1	0.3	0.4	0.6	-0.5	-0.6	-0.6
Hypothyroidism (self reported)	0.1	0.2	0.3	-0.5	0.4	0.5	0.3
Respiratory disease	1.1	2.4	2.8	-1.7	1.3	1.7	1.5
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.0	0.2	-0.1	0.1	0.0
Lung FEV1/FVC ratio	2.0	10.2	11.1	-3.1	3.3	3.1	3.2
Lung FVC	0.1	0.5	0.6	0.6	-0.8	-0.6	-0.8
Neuroticism	1.9	4.6	5.0	2.2	-2.1	-2.1	-2.1
Chronotype (morning person)	0.2	0.4	0.4	0.6	-0.7	-0.6	-0.6
Hair Pigment	0.5	14.9	16.0	-4.0	3.9	3.8	3.8
Tanning	0.1	1.6	1.7	1.2	-1.3	-1.3	-1.2
Hand grip strength (left)	0.3	0.7	0.9	-0.8	0.9	0.9	0.8
Number of treatments/medications taken	0.1	0.2	0.2	0.5	-0.3	-0.4	-0.5
Average weekly spirits intake	0.0	0.0	0.0	0.0	-0.1	0.1	0.0
Sensitivity / hurt feelings	3.5	6.0	6.4	2.5	-2.4	-2.5	-2.4
Frequency of depressed mood in last 2 weeks	2.1	2.9	3.3	1.6	-1.8	-1.7	-1.7
Hearing difficulty/problems: Yes	0.5	0.8	1.2	0.9	-0.8	-0.9	-1.1
Relative age of first facial hair	0.1	0.2	0.3	0.4	-0.5	-0.4	-0.5
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.7	-0.7	0.6	0.7	0.8
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.4	-0.6	0.6	0.5	0.6
Ever had hysterectomy (womb removed)	0.4	0.5	0.7	-0.8	0.7	0.6	0.6
Systolic blood pressure, automated reading	0.0	0.0	0.0	-0.1	-0.1	0.1	0.2
Eye problems/disorders: Diabetes related eye disease	6.4	7.0	7.6	-2.6	2.8	2.6	2.6
Angina	0.6	0.8	0.8	0.9	-0.9	-0.9	-0.8
Medication for hormone replacement therapy	0.1	0.1	0.2	0.4	-0.3	-0.4	-0.2
Vitamin and mineral supplements	0.0	0.0	0.0	-0.0	0.1	-0.0	-0.0
Supplements: Zinc	0.0	0.0	0.1	-0.3	0.1	0.2	0.2
Medication: Co-codamol	0.1	0.2	0.2	-0.4	0.3	0.5	0.4
Medication: Metformin	0.5	0.7	0.8	-0.8	0.7	0.9	0.8
Diabetes (father)	0.0	0.0	0.0	-0.1	0.1	0.1	0.1
Diabetes (mother)	1.2	1.5	1.8	1.2	-1.3	-1.1	-1.4
Severe depression (siblings)	0.0	0.0	0.0	-0.0	0.2	0.0	0.1
Pack years adult smoking proportion	0.1	0.2	0.4	0.3	-0.6	-0.3	-0.2
Impedance of leg (right)	2.7	13.3	14.4	-3.5	3.8	3.6	3.6
Leg fat-free mass (left)	0.0	0.2	0.3	0.4	-0.5	-0.4	-0.5
Trunk fat percentage	0.1	0.3	0.5	-0.5	0.7	0.5	0.4
Hand grip strength (right)	0.9	2.4	2.5	-1.5	1.6	1.6	1.5
Townsend deprivation index at recruitment	0.5	0.7	0.9	0.8	-0.9	-0.8	-0.9
Current tobacco smoking	0.0	0.0	0.0	-0.0	-0.2	0.1	0.1
Average weekly fortified wine intake	0.4	0.5	0.6	-0.7	0.6	0.7	0.7
Maternal smoking around birth	0.1	0.1	0.3	-0.3	0.5	0.3	0.3
Fed-up feelings	2.0	3.7	4.1	2.0	-1.7	-2.0	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	2.2	2.9	3.1	1.7	-1.6	-1.7	-1.8
Relative age voice broke	0.0	0.1	0.1	0.2	-0.3	-0.2	-0.3
Taking other prescription medications	0.5	0.8	1.2	-0.8	1.1	0.9	0.7
Age when periods started (menarche)	0.3	0.6	0.9	0.9	-0.7	-0.7	-0.7
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	-0.5	-0.1	0.4	0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.5	4.0	1.9	-1.7	-2.0	-2.0
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.1	-0.2	-0.2	0.1	0.1
Qualifications: CSEs or equivalent	0.2	0.3	0.7	0.4	-0.9	-0.4	-0.3
Serious illness, injury or assault to yourself	0.5	0.7	0.8	-0.7	0.9	0.8	0.9
High blood pressure	0.0	0.1	0.1	0.3	-0.3	-0.3	-0.3
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.1	0.9	-1.0	-0.9	-0.8
Multivitamins +/- minerals	0.1	0.1	0.2	0.4	-0.4	-0.3	-0.3
Stomach or abdominal pain in last month	1.7	2.1	2.4	1.4	-1.4	-1.4	-1.6
Supplements: Glucosamine	1.3	1.7	2.1	-1.4	1.1	1.4	1.3
Diverticular disease/diverticulitis (self-reported)	3.2	3.8	4.3	-2.0	1.7	2.1	2.0
Medication: Atenolol	0.4	0.5	0.9	-0.7	0.9	0.6	0.6
Medication: Levothyroxine sodium	0.0	0.0	0.0	-0.1	0.1	0.2	-0.0
Sitting height	0.8	5.7	6.2	-2.4	2.5	2.4	2.3
Chronic bronchitis/emphysema (father)	1.0	1.1	1.4	1.1	-1.0	-1.0	-1.2
High blood pressure (mother)	0.0	0.0	0.1	0.1	-0.3	-0.2	-0.0
Body mass index (BMI)	0.1	0.5	0.6	0.6	-0.7	-0.7	-0.8
Impedance of leg (left)	2.9	14.1	15.1	-3.7	3.9	3.7	3.7
Leg predicted mass (left)	0.0	0.3	0.3	0.5	-0.6	-0.5	-0.5
Trunk fat mass	0.1	0.4	0.5	-0.6	0.7	0.6	0.5
Waist circumference	1.0	3.7	3.9	-2.0	1.9	2.0	1.9
Number of incorrect matches in round	0.5	0.8	1.0	0.9	-0.7	-1.0	-0.9
Past tobacco smoking	0.2	0.3	0.4	-0.6	0.6	0.6	0.4
Alcohol usually taken with meals	0.2	0.3	0.4	-0.5	0.4	0.6	0.6
Nervous feelings	1.6	3.0	3.1	1.7	-1.8	-1.7	-1.7
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.0	1.0	-0.7	-1.0	-1.0
Hearing difficulty/problems with background noise	2.8	4.5	5.1	2.1	-2.3	-2.0	-2.1
Hair/balding pattern: Pattern 2	1.5	1.9	2.1	-1.4	1.2	1.5	1.4
Had menopause	1.6	2.0	2.1	-1.4	1.5	1.4	1.4
Had other major operations	1.2	1.4	1.6	-1.3	1.0	1.3	1.2
Forced vital capacity (FVC)	0.2	0.6	0.7	-0.9	0.7	0.9	0.7
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.1	4.5	2.1	-1.9	-2.1	-2.1
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	0.8	0.8	-0.9	-0.8	-0.7
Qualifications: None of the above	0.0	0.0	0.0	0.0	0.2	-0.0	-0.1
Financial difficulties in last 2 years	0.1	0.2	0.3	-0.4	0.4	0.4	0.5
Mouth/teeth dental problems	0.8	1.2	1.7	1.0	-1.3	-1.0	-1.0
Heart attack	0.1	0.2	0.3	0.5	-0.2	-0.4	-0.4
Allergy	0.6	1.5	2.0	-1.1	1.4	1.2	1.1
Pain all over the body in last month	0.2	0.2	0.3	0.4	-0.6	-0.3	-0.4
Diabetes (self-reported)	0.3	0.4	0.5	-0.7	0.5	0.7	0.7
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.4	-0.6	0.4	0.6	0.5
Medication: Ramipril	1.3	1.7	2.1	1.5	-1.0	-1.3	-1.3
Medication: Simvastatin	0.5	0.7	1.3	-0.8	1.1	0.7	0.8
Fluid intelligence score	0.0	0.0	0.1	-0.1	-0.0	-0.1	-0.2
Illnesses of siblings	0.3	0.5	0.8	-0.6	0.6	0.6	0.9
Neuroticism score	2.5	5.3	5.6	2.4	-2.3	-2.3	-2.3
Weight	0.1	0.6	0.7	-0.8	0.8	0.8	0.7
Impedance of arm (right)	0.0	0.0	0.1	0.2	0.1	-0.2	-0.1
Arm fat percentage (right)	0.3	1.0	1.2	1.0	-1.0	-1.0	-1.1
Trunk fat-free mass	0.2	1.3	1.5	-1.2	0.9	1.2	1.2
Hip circumference	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.2
Time employed in main current job	0.0	0.0	0.1	-0.1	0.3	0.1	0.1
Alcohol intake versus 10 years previously	0.1	0.1	0.2	-0.4	0.4	0.4	0.2
Father’s age at death	5.4	7.2	7.6	-2.8	2.5	2.7	2.8
Worrier / anxious feelings	1.6	2.9	3.1	1.7	-1.7	-1.7	-1.7
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	2.0	1.4	-1.1	-1.4	-1.3
Falls in the last year	0.9	1.2	1.3	1.0	-1.1	-1.1	-1.1
Hair/balding pattern: Pattern 3	0.4	0.6	0.9	-0.7	0.9	0.7	0.7
Number of live births	0.0	0.0	0.1	0.1	-0.3	-0.2	-0.2
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	2.7	-1.6	1.5	1.6	1.5
Pulse rate	5.0	8.5	9.1	-3.0	2.8	3.0	2.9
Happiness	0.2	0.2	0.4	-0.3	0.6	0.4	0.4
Noisy workplace	0.0	0.0	0.1	-0.0	-0.3	-0.0	-0.1
Qualifications: A levels/AS levels or equivalent	0.7	1.6	1.7	-1.3	1.2	1.3	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.5	0.7	-0.6	-0.7	-0.7
Mouth/teeth dental problems: Dentures	2.5	4.2	5.0	-2.0	2.2	2.1	2.0
Asthma	0.1	0.3	0.3	-0.6	0.4	0.6	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.2	1.0	-1.1	-1.0	-0.9
Medication: Cholesterol lowering	0.2	0.4	0.6	-0.5	0.8	0.6	0.6
Depression (self-reported)	0.8	1.0	1.2	0.9	-1.0	-1.0	-1.1
Medication: Lansoprazole	0.8	0.9	1.4	-0.8	1.2	0.8	1.0
Prospective memory result	0.3	0.4	0.4	0.6	-0.6	-0.6	-0.6
Lung cancer (father)	0.3	0.3	0.4	0.5	-0.4	-0.7	-0.6
Illnesses of mother	0.0	0.0	0.1	0.2	-0.2	-0.2	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	0.8	-0.9	0.7	0.9	0.8
Pulse wave Arterial Stiffness index	1.0	1.1	1.4	-1.2	0.9	1.1	1.0
Impedance of arm (left)	0.0	0.0	0.0	0.2	0.2	-0.2	-0.1
Arm fat mass (right)	0.0	0.1	0.1	0.3	-0.2	-0.3	-0.3
Trunk predicted mass	0.2	1.3	1.5	-1.2	0.9	1.2	1.2
Standing height	1.0	10.2	10.4	-3.2	3.2	3.2	3.2
Length of working week for main job	0.0	0.0	0.1	0.2	0.1	-0.2	-0.2
Exposure to tobacco smoke at home	0.0	0.0	0.1	0.2	-0.2	-0.1	-0.0
Breastfed as a baby	0.0	0.0	0.0	0.1	-0.1	-0.1	0.2
Tense / ‘highly strung’	0.8	1.3	1.9	1.0	-1.4	-1.1	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.1	-0.2	0.3	0.2	0.1
Hair/balding pattern: Pattern 4	0.7	1.7	1.8	1.3	-1.3	-1.3	-1.3
Birth weight of first child	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.1
Peak expiratory flow (PEF)	1.2	2.7	2.9	-1.7	1.7	1.7	1.5
Pulse wave reflection index	1.5	1.8	2.5	1.2	-1.6	-1.2	-1.3
Ever highly irritable/argumentative for 2 days	4.4	5.3	5.5	2.3	-2.3	-2.3	-2.2
Loud music exposure frequency	0.8	0.8	1.1	0.8	-1.1	-0.9	-0.8
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	2.6	-1.4	1.4	1.5	1.6
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.1	0.1	0.0	-0.3	-0.2
Blood clot in the leg (DVT)	0.0	0.0	0.0	-0.2	-0.0	0.1	-0.0
Medication: Paracetamol	0.1	0.1	0.2	0.4	-0.4	-0.4	-0.3
Headache pain in last month	0.3	0.5	0.6	-0.7	0.7	0.8	0.7
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.1	-0.3	0.1	0.2	0.2
Glaucoma (self-reported)	1.0	1.1	1.2	-1.1	1.1	1.1	1.0
Gout (self-reported)	0.4	0.6	0.9	0.9	-0.7	-0.7	-0.6
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.1	-0.3	0.3	0.3	0.1
Medication: Amlodipine	1.1	1.6	1.7	1.3	-1.3	-1.3	-1.2
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.4	0.7	-1.2	-0.8	-0.8
Birth weight	0.0	0.1	0.1	0.3	-0.2	-0.3	-0.1
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.1	0.4	-0.2	-0.4	-0.3
High blood pressure (siblings)	0.9	1.3	1.7	-1.1	1.3	1.1	1.0
Forced vital capacity (FVC), Best measure	0.1	0.5	0.7	-0.8	0.6	0.8	0.6
Body fat percentage	0.1	0.3	0.5	-0.6	0.7	0.6	0.4
Leg fat percentage (right)	0.3	1.0	1.1	-1.0	1.1	1.1	0.9
Arm fat-free mass (right)	0.4	2.0	2.3	-1.5	1.2	1.5	1.4
Exposure to tobacco smoke outside home	0.2	0.3	0.4	0.6	-0.6	-0.5	-0.5
Comparative body size at age 10	3.7	10.2	10.6	3.1	-3.1	-3.3	-3.2
Number of full brothers	0.5	0.7	0.9	0.8	-0.9	-0.8	-0.7
Worry too long after embarrassment	5.4	9.1	9.6	3.0	-3.1	-3.0	-2.9
Seen a psychiatrist for nerves, anxiety, tension or depression	3.1	4.0	4.1	-2.0	2.0	2.0	2.0
Wheeze or whistling in the chest in last year	0.0	0.0	0.0	-0.0	0.0	0.0	-0.0
Number of children fathered	0.7	0.8	0.9	1.0	-0.9	-0.9	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	2.6	-1.4	1.6	1.4	1.5
Age at first live birth	0.0	0.0	0.1	-0.1	0.3	0.1	0.1
Pulse wave peak to peak time	0.8	0.9	1.2	1.1	-0.8	-1.0	-0.9
Health satisfaction	1.1	1.4	1.6	-1.1	1.2	1.2	1.2
Shortness of breath walking on level ground	1.8	2.2	2.7	1.4	-1.5	-1.4	-1.6
Qualifications: College or University degree	0.5	1.5	1.5	-1.2	1.1	1.2	1.2
Eye problems/disorders: None of the above	0.2	0.2	0.3	-0.4	0.3	0.5	0.6
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	-0.1	0.1	0.1	0.1
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.5	0.3	0.4	0.3
Medication for pain relief, constipation, heartburn	0.7	1.2	1.3	-1.1	1.1	1.1	1.0
Neck or shoulder pain in last month	0.1	0.1	0.2	-0.5	0.2	0.4	0.4
Medication: Blood pressure	0.3	0.6	0.8	0.9	-0.7	-0.8	-0.7
Angina (self-reported)	0.5	0.7	0.7	0.9	-0.8	-0.8	-0.8
Migraine (self-reported)	0.1	0.1	0.1	-0.3	0.0	0.3	0.2
Medication: Ibuprofen	0.6	0.7	1.0	0.8	-1.0	-0.8	-0.7
Medication: Allopurinol	1.6	2.2	2.7	1.6	-1.4	-1.5	-1.3
Medication: Omeprazole	0.5	0.6	0.8	0.7	-0.9	-0.7	-0.7
Medication: Seretide 50 evohaler	0.2	0.2	0.3	-0.5	0.4	0.4	0.4
Mean time to correctly identify matches	0.0	0.0	0.1	0.1	-0.0	-0.1	-0.2
Heart disease (mother)	2.4	2.9	3.4	-1.7	1.9	1.7	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.2	0.4	-0.2	-0.5	-0.4
Whole body fat mass	0.0	0.2	0.3	-0.4	0.5	0.4	0.3
Leg fat mass (right)	0.1	0.2	0.2	-0.5	0.5	0.5	0.4
Arm predicted mass (right)	0.5	2.5	2.7	-1.6	1.4	1.6	1.6
Pulse rate, automated reading	14.2	45.9	46.8	-6.8	6.7	6.8	6.7
Alcohol intake frequency.	0.1	0.1	0.2	0.3	-0.4	-0.3	-0.4
Comparative height size at age 10	2.2	11.8	13.0	-3.4	3.6	3.4	3.3
Number of full sisters	3.2	3.9	4.1	-2.0	1.9	2.0	2.0
Suffer from ‘nerves’	3.0	4.7	4.8	2.2	-2.2	-2.1	-2.2
Overall health rating	0.7	1.5	1.6	1.3	-1.3	-1.2	-1.1
Chest pain or discomfort	0.9	1.2	1.6	1.0	-1.3	-1.1	-1.1
Had major operations	2.4	2.8	3.4	1.8	-1.4	-1.9	-1.6
Age at last live birth	0.2	0.3	0.3	0.5	-0.6	-0.4	-0.5
Family relationship satisfaction	0.0	0.0	0.1	0.3	0.0	-0.3	-0.0
Leg pain on walking	3.0	3.7	4.2	1.9	-1.8	-2.0	-2.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.3	-0.2	-0.4	-0.5
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.0	0.1	0.1	-0.2	-0.1
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.0	-0.0	0.1	0.0	-0.0
Medication: Aspirin	0.2	0.3	0.4	0.6	-0.4	-0.6	-0.6
Supplements: Vitamin C	6.2	7.3	7.8	-2.6	2.6	2.8	2.8
Knee pain experienced in last month	0.2	0.3	0.4	-0.7	0.5	0.5	0.6
Hypertension (Self-reported)	0.1	0.2	0.2	0.4	-0.4	-0.4	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	0.7	-0.8	0.9	0.8	0.8
Illnesses of father: Heart disease	2.2	3.0	3.2	-1.8	1.8	1.7	1.7
Illnesses of siblings: Diabetes	0.2	0.3	0.5	-0.5	0.7	0.6	0.4
Smoking status: Previous	0.4	0.6	0.8	0.8	-0.8	-0.9	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	0.7	-0.8	0.7	0.7	0.7
Whole body fat-free mass	0.0	0.3	0.4	-0.6	0.4	0.6	0.5
Leg fat-free mass (right)	0.1	0.3	0.4	0.5	-0.6	-0.5	-0.6
Arm fat percentage (left)	0.2	1.0	1.1	1.0	-0.9	-1.0	-1.1
Average weekly red wine intake	0.6	0.8	1.0	1.0	-0.8	-1.0	-0.9
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.6	-0.5	0.8	0.6	0.6
Mood swings	0.1	0.3	0.4	0.7	-0.3	-0.5	-0.5
Loneliness, isolation	0.0	0.0	0.0	-0.2	0.0	0.1	0.2
Long-standing illness, disability or infirmity	0.2	0.3	0.4	0.6	-0.4	-0.5	-0.6
Ever had bowel cancer screening	0.5	0.6	0.9	-0.7	0.9	0.7	0.7
Diabetes diagnosed by doctor	0.0	0.0	0.0	-0.2	0.1	0.2	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.0	-0.0	-0.0	-0.0	-0.1
Friendships satisfaction	0.3	0.3	0.4	-0.5	0.6	0.6	0.6
Qualifications: nursing, teaching	0.0	0.1	0.2	-0.1	0.1	0.2	0.4
Commuting to job workplace: Walk	0.5	0.5	0.6	-0.8	0.6	0.7	0.8
Eye problems/disorders: Cataract	1.8	2.0	2.1	1.4	-1.4	-1.4	-1.5
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	0.8	-0.8	0.7	0.8	0.9
Medication for cholesterol	0.0	0.0	0.0	-0.1	-0.0	0.2	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.5	1.7	1.3	-0.9	-1.3	-1.3
Back pain experienced in last month	0.7	1.0	1.1	-1.0	1.1	1.0	1.0
Mineral and other dietary supplements	0.6	0.8	0.8	0.8	-0.9	-0.9	-0.9
Breast cancer (self-reported)	0.7	0.9	1.0	0.9	-0.9	-1.0	-0.9
Asthma (self-reported)	0.2	0.3	0.4	-0.7	0.4	0.6	0.5
Osteoporosis (self-reported)	0.1	0.1	0.1	-0.3	0.2	0.3	0.4
Osteoarthritis (self-reported)	2.6	3.4	3.5	1.9	-1.8	-1.9	-1.8
Medication: Aspirin	0.1	0.2	0.2	0.5	-0.3	-0.5	-0.4
Medication: Gliclazide	0.3	0.3	0.4	-0.6	0.4	0.6	0.5
Illnesses of father: None of the above (group 1)	1.3	1.6	2.4	1.2	-1.5	-1.2	-1.2
Smoking status: Current	0.0	0.0	0.1	-0.2	-0.1	0.3	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	3.6	-1.8	1.8	1.9	1.9
Whole body water mass	0.0	0.2	0.3	-0.6	0.3	0.6	0.5
Leg predicted mass (right)	0.1	0.4	0.5	0.5	-0.7	-0.5	-0.6
Arm fat mass (left)	0.0	0.2	0.2	0.4	-0.4	-0.4	-0.5
Number of self-reported non-cancer illnesses	1.3	2.2	2.5	-1.5	1.3	1.6	1.4
Average weekly champagne plus white wine intake	0.7	0.9	1.0	1.0	-1.0	-1.0	-0.8
Miserableness	1.9	3.3	3.7	1.9	-1.8	-1.9	-1.7
Guilty feelings	0.9	1.4	1.5	1.2	-1.2	-1.2	-1.0
Wears glasses or contact lenses	0.0	0.0	0.0	-0.1	0.2	0.2	0.1
Ever taken oral contraceptive pill	0.5	0.6	0.7	0.8	-0.7	-0.8	-0.8
Hearing aid user	0.3	0.3	0.6	-0.6	0.8	0.5	0.4
Mother’s age at death	2.5	3.1	3.4	1.6	-1.8	-1.8	-1.8
Financial situation satisfaction	3.7	4.5	5.8	2.1	-2.4	-2.0	-2.0
Tinnitus: Yes, now most or all of the time	5.0	5.9	6.7	2.6	-2.2	-2.5	-2.4
Commuting to job workplace: Public transport	1.7	2.0	2.1	-1.4	1.4	1.5	1.5
Eye problems/disorders: Glaucoma	1.8	2.1	2.5	-1.5	1.6	1.5	1.2
Medication: Blood pressure	0.1	0.2	0.2	-0.4	0.5	0.3	0.4
Pain type(s) experienced in last month: Hip pain	1.6	2.1	2.5	1.3	-1.6	-1.4	-1.4
Supplements: Fish oil (including cod liver oil)	0.0	0.1	0.1	-0.2	0.2	0.2	0.3
High cholesterol (Self-reported)	0.7	1.2	2.3	-0.9	1.5	0.9	0.9
Medication: Bendroflumethiazide	0.3	0.4	0.5	-0.6	0.7	0.6	0.7
Medication: Paracetamol	0.0	0.0	0.0	0.1	-0.2	-0.1	0.0
Medication: Lisinopril	0.8	1.1	1.3	1.1	-0.9	-1.1	-1.0
Medication: Atorvastatin	0.2	0.2	0.3	0.6	-0.5	-0.4	-0.5
Illnesses of father: High blood pressure	2.4	3.0	3.5	-1.7	1.6	1.7	1.9
Alcohol drinker status: Never	0.9	1.1	1.3	-1.0	1.2	1.0	1.1
Ever smoked	0.4	0.7	1.0	0.9	-1.0	-0.8	-0.7
Basal metabolic rate	0.1	0.3	0.4	-0.7	0.5	0.6	0.6
Leg fat percentage (left)	0.4	1.3	1.4	-1.2	1.2	1.2	1.0
Arm fat-free mass (left)	0.5	2.8	3.0	-1.7	1.5	1.7	1.7
Number of operations (self-reported)	1.1	1.6	1.9	-1.3	1.1	1.2	1.4
Average weekly beer plus cider intake	0.0	0.0	0.0	0.1	-0.1	-0.0	-0.0
Irritability	0.8	1.4	1.8	1.2	-1.0	-1.2	-1.3
Risk taking	0.0	0.1	0.1	-0.3	0.2	0.2	0.3
Ever had prostate specific antigen (PSA) test	1.6	1.8	2.2	1.5	-1.1	-1.4	-1.4
Fractured/broken bones in last 5 years	0.8	1.1	1.5	-1.1	0.7	1.1	1.2
Age started oral contraceptive pill	0.3	0.3	0.6	-0.4	0.8	0.5	0.5
Diastolic blood pressure, automated reading	4.7	14.7	15.5	-3.9	3.6	3.9	3.9
Ever depressed for a whole week	0.1	0.1	0.1	0.3	-0.3	-0.3	-0.3
Unable to work because of sickness or disability	1.0	1.3	1.6	1.2	-0.9	-1.2	-1.3
Commuting to job workplace: Cycle	0.0	0.1	0.1	-0.2	-0.2	0.2	0.3
Myopia	1.1	1.6	1.8	-1.2	1.2	1.2	1.4
Vascular/heart problems diagnosed by doctor	0.0	0.0	0.0	-0.2	0.2	0.2	0.2
Cholesterol lowering medication	0.2	0.3	0.5	-0.5	0.7	0.4	0.4
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.0	0.0	-0.1	-0.0	-0.0
Pain experienced in last month	0.9	1.5	1.6	1.2	-1.1	-1.3	-1.3
Supplements: Calcium	1.2	1.3	1.5	-1.1	1.1	1.1	1.2
Basal cell carcinoma (self-reported)	0.5	0.6	0.7	0.8	-0.8	-0.8	-0.7
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.1	0.3	-0.0	-0.1	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.1	-0.4	0.2	0.3	0.2
Heart disease (siblings)	2.0	2.5	2.8	1.6	-1.4	-1.6	-1.7
Alcohol drinker status: Previous	0.5	0.6	0.7	0.8	-0.7	-0.8	-0.8
Pack years of smoking	0.3	0.5	0.8	0.6	-0.9	-0.6	-0.6
Impedance of whole body	0.7	3.4	4.3	-1.7	2.1	1.8	1.8
Leg fat mass (left)	0.1	0.4	0.4	-0.6	0.6	0.6	0.5
Arm predicted mass (left)	0.5	2.4	2.7	-1.6	1.4	1.6	1.6