Hub : Genes

COPS3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0610 0.0300 7.6e-03 0.037 0.010 0.013 0.018 0.027 2.5e-05 1.9e-02 9.5e-03 2.7e-03 2.4e-04
2 GTEx Whole Blood 0.1440 0.0360 5.8e-10 0.173 NA 0.157 NA 0.160 8.7e-16 NA 2.4e-14 NA 1.3e-14
3 NTR Blood 0.0306 0.0104 1.3e-05 0.028 0.021 0.020 0.023 0.025 1.7e-09 1.9e-07 2.9e-07 3.4e-08 1.4e-08
4 YFS Blood 0.1688 0.0270 0.0e+00 0.216 0.186 0.213 0.210 0.216 5.9e-69 2.0e-58 6.0e-68 6.3e-67 8.3e-69

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.0 0.0 0.1 0.2 0.0 -0.3 -0.1
Bipolar Disorder or Schizophrenia 0.6 1.6 2.2 -1.2 1.5 1.1 1.2
Depressed Affect (Nagel 2018) 0.1 0.2 0.4 0.6 -0.4 -0.5 -0.3
Depression (Nagel 2018) 0.8 1.3 1.3 1.1 -1.1 -1.1 -1.1
Intelligence (Savage-Jansen 2018) 0.7 2.2 2.6 -1.6 1.6 1.5 1.3
Neuroticism (Nagel 2018) 1.4 3.4 3.8 2.0 -1.9 -1.8 -1.7
Schizophrenia (2018) 1.4 3.0 3.5 -1.7 1.9 1.6 1.7
Schizophrenia vs Biploar Disorder 1.4 1.8 1.9 -1.4 1.4 1.3 1.2
Worry (Nagel 2018) 0.8 1.6 1.8 1.3 -1.3 -1.2 -1.2
Alzheimer’s Disease (in mother) 0.4 0.4 0.6 -0.8 0.5 0.7 0.6
Alzheimer’s Disease (in father) 1.7 1.8 2.1 1.5 -1.2 -1.4 -1.4
Alzheimer’s Disease (including proxy) 0.2 0.3 0.3 0.6 -0.4 -0.5 -0.5
Crohns Disease (2017) 1.1 2.4 3.0 1.7 -1.4 -1.5 -1.6
Irritable Bowel Disease (IBD) 1.1 2.6 3.2 1.8 -1.6 -1.5 -1.5
Ulcerative Colitis (UC) 0.9 1.8 2.1 1.4 -1.4 -1.2 -1.2
Major Depression (MDD) 1.3 1.6 1.8 -1.2 1.2 1.2 1.4
Reaction Time 0.1 0.3 0.4 -0.5 0.4 0.6 0.5
Verbal and Numeric Reasoning (VNR) 0.2 0.4 0.5 -0.7 0.7 0.6 0.4
Breast Cancer 0.6 1.5 2.0 1.0 -1.4 -1.2 -1.2
Ovarian Cancer 2.3 3.0 3.6 1.7 -1.9 -1.6 -1.7
Prostate Cancer 0.3 0.5 0.5 0.7 -0.6 -0.7 -0.7
Age at First Birth 2.2 3.3 3.6 1.6 -1.9 -1.8 -1.9
Bipolar Disorder (2011) 0.0 0.0 0.0 -0.1 0.0 0.0 0.2
Body Mass Index (BMI) (2010) 0.2 0.2 0.4 -0.4 0.6 0.4 0.4
Coronary Artery Disease (CAD) 0.3 0.4 0.5 -0.4 0.7 0.7 0.7
Crohns Disease (2012) 2.4 3.8 4.2 2.1 -1.9 -2.0 -1.9
Mean Putamen Volume 1.1 1.2 1.7 1.3 -1.0 -1.1 -1.0
Fasting Glucose 0.0 0.0 0.0 0.1 -0.2 -0.1 0.0
HbA1C 0.0 0.0 0.0 -0.1 -0.1 0.1 0.2
HDL Cholesterol 0.5 0.8 1.0 0.9 -0.9 -0.9 -1.0
LDL Cholesterol 1.2 2.0 2.3 -1.5 1.4 1.3 1.4
Lupus 0.2 0.3 0.5 -0.6 0.4 0.7 0.4
Neuroticism (2016) 1.3 1.9 2.1 1.4 -1.4 -1.3 -1.4
Primary Biliary Cirrhosis 0.1 0.1 0.3 -0.1 0.5 0.3 0.2
Rheumatoid Arthritis 0.0 0.0 0.0 0.0 0.0 0.1 0.1
Schizophrenia (2014) 0.6 1.4 2.1 -1.1 1.4 1.1 1.0
Triglycerides 0.0 0.0 0.1 0.2 -0.2 -0.0 -0.2
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.2 0.4 -0.3 -0.2 -0.5
Ulcerative Colitis 0.9 1.3 1.6 1.3 -1.2 -1.0 -1.0
Blood Eosinophil Count 0.2 1.7 2.0 1.4 -1.1 -1.3 -1.3
Blood Platelet Count 2.1 23.9 26.7 4.7 -5.2 -4.8 -4.8
Blood Red Count 0.1 0.5 0.8 -0.9 0.5 0.8 0.4
Blood White Count 0.0 0.0 0.0 0.1 -0.2 -0.0 -0.1
Heel T-Score 6.9 54.8 57.8 7.5 -6.9 -7.6 -7.6
BMI 0.2 1.4 1.6 1.1 -1.2 -1.1 -1.3
Height 0.7 12.7 13.5 -3.5 3.5 3.7 3.6
Waist Hip Ratio (WHR) 1.0 4.4 4.8 -1.9 2.1 2.2 2.2
Systolic Blood Pressure 0.4 2.2 2.8 1.6 -1.7 -1.4 -1.3
Smoking Status 0.3 0.7 1.1 0.8 -1.0 -0.7 -0.6
Allergy or Eczema 0.3 0.7 0.9 0.8 -1.0 -0.8 -0.7
Cardiovascular Disease 0.1 0.3 0.4 0.6 -0.5 -0.6 -0.6
Hypothyroidism (self reported) 0.1 0.2 0.3 -0.5 0.4 0.5 0.3
Respiratory disease 1.1 2.4 2.8 -1.7 1.3 1.7 1.5
Type 2 Diabetes (T2D) (2018) 0.0 0.0 0.0 0.2 -0.1 0.1 0.0
Lung FEV1/FVC ratio 2.0 10.2 11.1 -3.1 3.3 3.1 3.2
Lung FVC 0.1 0.5 0.6 0.6 -0.8 -0.6 -0.8
Neuroticism 1.9 4.6 5.0 2.2 -2.1 -2.1 -2.1
Chronotype (morning person) 0.2 0.4 0.4 0.6 -0.7 -0.6 -0.6
Hair Pigment 0.5 14.9 16.0 -4.0 3.9 3.8 3.8
Tanning 0.1 1.6 1.7 1.2 -1.3 -1.3 -1.2
Hand grip strength (left) 0.3 0.7 0.9 -0.8 0.9 0.9 0.8
Number of treatments/medications taken 0.1 0.2 0.2 0.5 -0.3 -0.4 -0.5
Average weekly spirits intake 0.0 0.0 0.0 0.0 -0.1 0.1 0.0
Sensitivity / hurt feelings 3.5 6.0 6.4 2.5 -2.4 -2.5 -2.4
Frequency of depressed mood in last 2 weeks 2.1 2.9 3.3 1.6 -1.8 -1.7 -1.7
Hearing difficulty/problems: Yes 0.5 0.8 1.2 0.9 -0.8 -0.9 -1.1
Relative age of first facial hair 0.1 0.2 0.3 0.4 -0.5 -0.4 -0.5
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 0.7 -0.7 0.6 0.7 0.8
Ever used hormone-replacement therapy (HRT) 0.3 0.3 0.4 -0.6 0.6 0.5 0.6
Ever had hysterectomy (womb removed) 0.4 0.5 0.7 -0.8 0.7 0.6 0.6
Systolic blood pressure, automated reading 0.0 0.0 0.0 -0.1 -0.1 0.1 0.2
Eye problems/disorders: Diabetes related eye disease 6.4 7.0 7.6 -2.6 2.8 2.6 2.6
Angina 0.6 0.8 0.8 0.9 -0.9 -0.9 -0.8
Medication for hormone replacement therapy 0.1 0.1 0.2 0.4 -0.3 -0.4 -0.2
Vitamin and mineral supplements 0.0 0.0 0.0 -0.0 0.1 -0.0 -0.0
Supplements: Zinc 0.0 0.0 0.1 -0.3 0.1 0.2 0.2
Medication: Co-codamol 0.1 0.2 0.2 -0.4 0.3 0.5 0.4
Medication: Metformin 0.5 0.7 0.8 -0.8 0.7 0.9 0.8
Diabetes (father) 0.0 0.0 0.0 -0.1 0.1 0.1 0.1
Diabetes (mother) 1.2 1.5 1.8 1.2 -1.3 -1.1 -1.4
Severe depression (siblings) 0.0 0.0 0.0 -0.0 0.2 0.0 0.1
Pack years adult smoking proportion 0.1 0.2 0.4 0.3 -0.6 -0.3 -0.2
Impedance of leg (right) 2.7 13.3 14.4 -3.5 3.8 3.6 3.6
Leg fat-free mass (left) 0.0 0.2 0.3 0.4 -0.5 -0.4 -0.5
Trunk fat percentage 0.1 0.3 0.5 -0.5 0.7 0.5 0.4
Hand grip strength (right) 0.9 2.4 2.5 -1.5 1.6 1.6 1.5
Townsend deprivation index at recruitment 0.5 0.7 0.9 0.8 -0.9 -0.8 -0.9
Current tobacco smoking 0.0 0.0 0.0 -0.0 -0.2 0.1 0.1
Average weekly fortified wine intake 0.4 0.5 0.6 -0.7 0.6 0.7 0.7
Maternal smoking around birth 0.1 0.1 0.3 -0.3 0.5 0.3 0.3
Fed-up feelings 2.0 3.7 4.1 2.0 -1.7 -2.0 -1.9
Frequency of unenthusiasm / disinterest in last 2 weeks 2.2 2.9 3.1 1.7 -1.6 -1.7 -1.8
Relative age voice broke 0.0 0.1 0.1 0.2 -0.3 -0.2 -0.3
Taking other prescription medications 0.5 0.8 1.2 -0.8 1.1 0.9 0.7
Age when periods started (menarche) 0.3 0.6 0.9 0.9 -0.7 -0.7 -0.7
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.2 -0.5 -0.1 0.4 0.4
Heel bone mineral density (BMD) T-score, automated (left) 1.6 3.5 4.0 1.9 -1.7 -2.0 -2.0
Tinnitus: Yes, but not now, but have in the past 0.0 0.0 0.1 -0.2 -0.2 0.1 0.1
Qualifications: CSEs or equivalent 0.2 0.3 0.7 0.4 -0.9 -0.4 -0.3
Serious illness, injury or assault to yourself 0.5 0.7 0.8 -0.7 0.9 0.8 0.9
High blood pressure 0.0 0.1 0.1 0.3 -0.3 -0.3 -0.3
Hayfever, allergic rhinitis or eczema 0.4 0.8 1.1 0.9 -1.0 -0.9 -0.8
Multivitamins +/- minerals 0.1 0.1 0.2 0.4 -0.4 -0.3 -0.3
Stomach or abdominal pain in last month 1.7 2.1 2.4 1.4 -1.4 -1.4 -1.6
Supplements: Glucosamine 1.3 1.7 2.1 -1.4 1.1 1.4 1.3
Diverticular disease/diverticulitis (self-reported) 3.2 3.8 4.3 -2.0 1.7 2.1 2.0
Medication: Atenolol 0.4 0.5 0.9 -0.7 0.9 0.6 0.6
Medication: Levothyroxine sodium 0.0 0.0 0.0 -0.1 0.1 0.2 -0.0
Sitting height 0.8 5.7 6.2 -2.4 2.5 2.4 2.3
Chronic bronchitis/emphysema (father) 1.0 1.1 1.4 1.1 -1.0 -1.0 -1.2
High blood pressure (mother) 0.0 0.0 0.1 0.1 -0.3 -0.2 -0.0
Body mass index (BMI) 0.1 0.5 0.6 0.6 -0.7 -0.7 -0.8
Impedance of leg (left) 2.9 14.1 15.1 -3.7 3.9 3.7 3.7
Leg predicted mass (left) 0.0 0.3 0.3 0.5 -0.6 -0.5 -0.5
Trunk fat mass 0.1 0.4 0.5 -0.6 0.7 0.6 0.5
Waist circumference 1.0 3.7 3.9 -2.0 1.9 2.0 1.9
Number of incorrect matches in round 0.5 0.8 1.0 0.9 -0.7 -1.0 -0.9
Past tobacco smoking 0.2 0.3 0.4 -0.6 0.6 0.6 0.4
Alcohol usually taken with meals 0.2 0.3 0.4 -0.5 0.4 0.6 0.6
Nervous feelings 1.6 3.0 3.1 1.7 -1.8 -1.7 -1.7
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 1.0 1.0 -0.7 -1.0 -1.0
Hearing difficulty/problems with background noise 2.8 4.5 5.1 2.1 -2.3 -2.0 -2.1
Hair/balding pattern: Pattern 2 1.5 1.9 2.1 -1.4 1.2 1.5 1.4
Had menopause 1.6 2.0 2.1 -1.4 1.5 1.4 1.4
Had other major operations 1.2 1.4 1.6 -1.3 1.0 1.3 1.2
Forced vital capacity (FVC) 0.2 0.6 0.7 -0.9 0.7 0.9 0.7
Heel bone mineral density (BMD) T-score, automated (right) 1.8 4.1 4.5 2.1 -1.9 -2.1 -2.1
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 0.8 0.8 -0.9 -0.8 -0.7
Qualifications: None of the above 0.0 0.0 0.0 0.0 0.2 -0.0 -0.1
Financial difficulties in last 2 years 0.1 0.2 0.3 -0.4 0.4 0.4 0.5
Mouth/teeth dental problems 0.8 1.2 1.7 1.0 -1.3 -1.0 -1.0
Heart attack 0.1 0.2 0.3 0.5 -0.2 -0.4 -0.4
Allergy 0.6 1.5 2.0 -1.1 1.4 1.2 1.1
Pain all over the body in last month 0.2 0.2 0.3 0.4 -0.6 -0.3 -0.4
Diabetes (self-reported) 0.3 0.4 0.5 -0.7 0.5 0.7 0.7
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.4 -0.6 0.4 0.6 0.5
Medication: Ramipril 1.3 1.7 2.1 1.5 -1.0 -1.3 -1.3
Medication: Simvastatin 0.5 0.7 1.3 -0.8 1.1 0.7 0.8
Fluid intelligence score 0.0 0.0 0.1 -0.1 -0.0 -0.1 -0.2
Illnesses of siblings 0.3 0.5 0.8 -0.6 0.6 0.6 0.9
Neuroticism score 2.5 5.3 5.6 2.4 -2.3 -2.3 -2.3
Weight 0.1 0.6 0.7 -0.8 0.8 0.8 0.7
Impedance of arm (right) 0.0 0.0 0.1 0.2 0.1 -0.2 -0.1
Arm fat percentage (right) 0.3 1.0 1.2 1.0 -1.0 -1.0 -1.1
Trunk fat-free mass 0.2 1.3 1.5 -1.2 0.9 1.2 1.2
Hip circumference 0.0 0.0 0.1 0.1 -0.1 -0.1 -0.2
Time employed in main current job 0.0 0.0 0.1 -0.1 0.3 0.1 0.1
Alcohol intake versus 10 years previously 0.1 0.1 0.2 -0.4 0.4 0.4 0.2
Father’s age at death 5.4 7.2 7.6 -2.8 2.5 2.7 2.8
Worrier / anxious feelings 1.6 2.9 3.1 1.7 -1.7 -1.7 -1.7
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.8 2.0 1.4 -1.1 -1.4 -1.3
Falls in the last year 0.9 1.2 1.3 1.0 -1.1 -1.1 -1.1
Hair/balding pattern: Pattern 3 0.4 0.6 0.9 -0.7 0.9 0.7 0.7
Number of live births 0.0 0.0 0.1 0.1 -0.3 -0.2 -0.2
Forced expiratory volume in 1-second (FEV1) 0.7 2.5 2.7 -1.6 1.5 1.6 1.5
Pulse rate 5.0 8.5 9.1 -3.0 2.8 3.0 2.9
Happiness 0.2 0.2 0.4 -0.3 0.6 0.4 0.4
Noisy workplace 0.0 0.0 0.1 -0.0 -0.3 -0.0 -0.1
Qualifications: A levels/AS levels or equivalent 0.7 1.6 1.7 -1.3 1.2 1.3 1.3
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 0.5 0.7 -0.6 -0.7 -0.7
Mouth/teeth dental problems: Dentures 2.5 4.2 5.0 -2.0 2.2 2.1 2.0
Asthma 0.1 0.3 0.3 -0.6 0.4 0.6 0.5
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 1.2 1.0 -1.1 -1.0 -0.9
Medication: Cholesterol lowering 0.2 0.4 0.6 -0.5 0.8 0.6 0.6
Depression (self-reported) 0.8 1.0 1.2 0.9 -1.0 -1.0 -1.1
Medication: Lansoprazole 0.8 0.9 1.4 -0.8 1.2 0.8 1.0
Prospective memory result 0.3 0.4 0.4 0.6 -0.6 -0.6 -0.6
Lung cancer (father) 0.3 0.3 0.4 0.5 -0.4 -0.7 -0.6
Illnesses of mother 0.0 0.0 0.1 0.2 -0.2 -0.2 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 0.8 -0.9 0.7 0.9 0.8
Pulse wave Arterial Stiffness index 1.0 1.1 1.4 -1.2 0.9 1.1 1.0
Impedance of arm (left) 0.0 0.0 0.0 0.2 0.2 -0.2 -0.1
Arm fat mass (right) 0.0 0.1 0.1 0.3 -0.2 -0.3 -0.3
Trunk predicted mass 0.2 1.3 1.5 -1.2 0.9 1.2 1.2
Standing height 1.0 10.2 10.4 -3.2 3.2 3.2 3.2
Length of working week for main job 0.0 0.0 0.1 0.2 0.1 -0.2 -0.2
Exposure to tobacco smoke at home 0.0 0.0 0.1 0.2 -0.2 -0.1 -0.0
Breastfed as a baby 0.0 0.0 0.0 0.1 -0.1 -0.1 0.2
Tense / ‘highly strung’ 0.8 1.3 1.9 1.0 -1.4 -1.1 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.0 0.1 0.1 -0.2 0.3 0.2 0.1
Hair/balding pattern: Pattern 4 0.7 1.7 1.8 1.3 -1.3 -1.3 -1.3
Birth weight of first child 0.0 0.0 0.0 -0.1 0.1 -0.1 -0.1
Peak expiratory flow (PEF) 1.2 2.7 2.9 -1.7 1.7 1.7 1.5
Pulse wave reflection index 1.5 1.8 2.5 1.2 -1.6 -1.2 -1.3
Ever highly irritable/argumentative for 2 days 4.4 5.3 5.5 2.3 -2.3 -2.3 -2.2
Loud music exposure frequency 0.8 0.8 1.1 0.8 -1.1 -0.9 -0.8
Qualifications: O levels/GCSEs or equivalent 1.4 2.2 2.6 -1.4 1.4 1.5 1.6
Mouth/teeth dental problems: Bleeding gums 0.0 0.0 0.1 0.1 0.0 -0.3 -0.2
Blood clot in the leg (DVT) 0.0 0.0 0.0 -0.2 -0.0 0.1 -0.0
Medication: Paracetamol 0.1 0.1 0.2 0.4 -0.4 -0.4 -0.3
Headache pain in last month 0.3 0.5 0.6 -0.7 0.7 0.8 0.7
Medication for cholesterol, blood pressure or diabetes 0.0 0.0 0.1 -0.3 0.1 0.2 0.2
Glaucoma (self-reported) 1.0 1.1 1.2 -1.1 1.1 1.1 1.0
Gout (self-reported) 0.4 0.6 0.9 0.9 -0.7 -0.7 -0.6
Hypothyroidism/myxoedema (self-reported) 0.0 0.1 0.1 -0.3 0.3 0.3 0.1
Medication: Amlodipine 1.1 1.6 1.7 1.3 -1.3 -1.3 -1.2
Medication: Ventolin 100micrograms inhaler 0.6 0.8 1.4 0.7 -1.2 -0.8 -0.8
Birth weight 0.0 0.1 0.1 0.3 -0.2 -0.3 -0.1
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.1 0.4 -0.2 -0.4 -0.3
High blood pressure (siblings) 0.9 1.3 1.7 -1.1 1.3 1.1 1.0
Forced vital capacity (FVC), Best measure 0.1 0.5 0.7 -0.8 0.6 0.8 0.6
Body fat percentage 0.1 0.3 0.5 -0.6 0.7 0.6 0.4
Leg fat percentage (right) 0.3 1.0 1.1 -1.0 1.1 1.1 0.9
Arm fat-free mass (right) 0.4 2.0 2.3 -1.5 1.2 1.5 1.4
Exposure to tobacco smoke outside home 0.2 0.3 0.4 0.6 -0.6 -0.5 -0.5
Comparative body size at age 10 3.7 10.2 10.6 3.1 -3.1 -3.3 -3.2
Number of full brothers 0.5 0.7 0.9 0.8 -0.9 -0.8 -0.7
Worry too long after embarrassment 5.4 9.1 9.6 3.0 -3.1 -3.0 -2.9
Seen a psychiatrist for nerves, anxiety, tension or depression 3.1 4.0 4.1 -2.0 2.0 2.0 2.0
Wheeze or whistling in the chest in last year 0.0 0.0 0.0 -0.0 0.0 0.0 -0.0
Number of children fathered 0.7 0.8 0.9 1.0 -0.9 -0.9 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 1.9 2.2 2.6 -1.4 1.6 1.4 1.5
Age at first live birth 0.0 0.0 0.1 -0.1 0.3 0.1 0.1
Pulse wave peak to peak time 0.8 0.9 1.2 1.1 -0.8 -1.0 -0.9
Health satisfaction 1.1 1.4 1.6 -1.1 1.2 1.2 1.2
Shortness of breath walking on level ground 1.8 2.2 2.7 1.4 -1.5 -1.4 -1.6
Qualifications: College or University degree 0.5 1.5 1.5 -1.2 1.1 1.2 1.2
Eye problems/disorders: None of the above 0.2 0.2 0.3 -0.4 0.3 0.5 0.6
Mouth/teeth dental problems: Loose teeth 0.0 0.0 0.0 -0.1 0.1 0.1 0.1
Emphysema/chronic bronchitis 0.1 0.1 0.2 -0.5 0.3 0.4 0.3
Medication for pain relief, constipation, heartburn 0.7 1.2 1.3 -1.1 1.1 1.1 1.0
Neck or shoulder pain in last month 0.1 0.1 0.2 -0.5 0.2 0.4 0.4
Medication: Blood pressure 0.3 0.6 0.8 0.9 -0.7 -0.8 -0.7
Angina (self-reported) 0.5 0.7 0.7 0.9 -0.8 -0.8 -0.8
Migraine (self-reported) 0.1 0.1 0.1 -0.3 0.0 0.3 0.2
Medication: Ibuprofen 0.6 0.7 1.0 0.8 -1.0 -0.8 -0.7
Medication: Allopurinol 1.6 2.2 2.7 1.6 -1.4 -1.5 -1.3
Medication: Omeprazole 0.5 0.6 0.8 0.7 -0.9 -0.7 -0.7
Medication: Seretide 50 evohaler 0.2 0.2 0.3 -0.5 0.4 0.4 0.4
Mean time to correctly identify matches 0.0 0.0 0.1 0.1 -0.0 -0.1 -0.2
Heart disease (mother) 2.4 2.9 3.4 -1.7 1.9 1.7 1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.2 0.2 0.4 -0.2 -0.5 -0.4
Whole body fat mass 0.0 0.2 0.3 -0.4 0.5 0.4 0.3
Leg fat mass (right) 0.1 0.2 0.2 -0.5 0.5 0.5 0.4
Arm predicted mass (right) 0.5 2.5 2.7 -1.6 1.4 1.6 1.6
Pulse rate, automated reading 14.2 45.9 46.8 -6.8 6.7 6.8 6.7
Alcohol intake frequency. 0.1 0.1 0.2 0.3 -0.4 -0.3 -0.4
Comparative height size at age 10 2.2 11.8 13.0 -3.4 3.6 3.4 3.3
Number of full sisters 3.2 3.9 4.1 -2.0 1.9 2.0 2.0
Suffer from ‘nerves’ 3.0 4.7 4.8 2.2 -2.2 -2.1 -2.2
Overall health rating 0.7 1.5 1.6 1.3 -1.3 -1.2 -1.1
Chest pain or discomfort 0.9 1.2 1.6 1.0 -1.3 -1.1 -1.1
Had major operations 2.4 2.8 3.4 1.8 -1.4 -1.9 -1.6
Age at last live birth 0.2 0.3 0.3 0.5 -0.6 -0.4 -0.5
Family relationship satisfaction 0.0 0.0 0.1 0.3 0.0 -0.3 -0.0
Leg pain on walking 3.0 3.7 4.2 1.9 -1.8 -2.0 -2.1
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.2 0.3 -0.2 -0.4 -0.5
Commuting to job workplace: Car/motor vehicle 0.0 0.0 0.0 0.1 0.1 -0.2 -0.1
Illness, injury, bereavement, stress in last 2 years 0.0 0.0 0.0 -0.0 0.1 0.0 -0.0
Medication: Aspirin 0.2 0.3 0.4 0.6 -0.4 -0.6 -0.6
Supplements: Vitamin C 6.2 7.3 7.8 -2.6 2.6 2.8 2.8
Knee pain experienced in last month 0.2 0.3 0.4 -0.7 0.5 0.5 0.6
Hypertension (Self-reported) 0.1 0.2 0.2 0.4 -0.4 -0.4 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 0.7 -0.8 0.9 0.8 0.8
Illnesses of father: Heart disease 2.2 3.0 3.2 -1.8 1.8 1.7 1.7
Illnesses of siblings: Diabetes 0.2 0.3 0.5 -0.5 0.7 0.6 0.4
Smoking status: Previous 0.4 0.6 0.8 0.8 -0.8 -0.9 -0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.5 0.7 -0.8 0.7 0.7 0.7
Whole body fat-free mass 0.0 0.3 0.4 -0.6 0.4 0.6 0.5
Leg fat-free mass (right) 0.1 0.3 0.4 0.5 -0.6 -0.5 -0.6
Arm fat percentage (left) 0.2 1.0 1.1 1.0 -0.9 -1.0 -1.1
Average weekly red wine intake 0.6 0.8 1.0 1.0 -0.8 -1.0 -0.9
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.6 -0.5 0.8 0.6 0.6
Mood swings 0.1 0.3 0.4 0.7 -0.3 -0.5 -0.5
Loneliness, isolation 0.0 0.0 0.0 -0.2 0.0 0.1 0.2
Long-standing illness, disability or infirmity 0.2 0.3 0.4 0.6 -0.4 -0.5 -0.6
Ever had bowel cancer screening 0.5 0.6 0.9 -0.7 0.9 0.7 0.7
Diabetes diagnosed by doctor 0.0 0.0 0.0 -0.2 0.1 0.2 0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.0 0.0 0.0 -0.0 -0.0 -0.0 -0.1
Friendships satisfaction 0.3 0.3 0.4 -0.5 0.6 0.6 0.6
Qualifications: nursing, teaching 0.0 0.1 0.2 -0.1 0.1 0.2 0.4
Commuting to job workplace: Walk 0.5 0.5 0.6 -0.8 0.6 0.7 0.8
Eye problems/disorders: Cataract 1.8 2.0 2.1 1.4 -1.4 -1.4 -1.5
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 0.8 -0.8 0.7 0.8 0.9
Medication for cholesterol 0.0 0.0 0.0 -0.1 -0.0 0.2 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.5 1.7 1.3 -0.9 -1.3 -1.3
Back pain experienced in last month 0.7 1.0 1.1 -1.0 1.1 1.0 1.0
Mineral and other dietary supplements 0.6 0.8 0.8 0.8 -0.9 -0.9 -0.9
Breast cancer (self-reported) 0.7 0.9 1.0 0.9 -0.9 -1.0 -0.9
Asthma (self-reported) 0.2 0.3 0.4 -0.7 0.4 0.6 0.5
Osteoporosis (self-reported) 0.1 0.1 0.1 -0.3 0.2 0.3 0.4
Osteoarthritis (self-reported) 2.6 3.4 3.5 1.9 -1.8 -1.9 -1.8
Medication: Aspirin 0.1 0.2 0.2 0.5 -0.3 -0.5 -0.4
Medication: Gliclazide 0.3 0.3 0.4 -0.6 0.4 0.6 0.5
Illnesses of father: None of the above (group 1) 1.3 1.6 2.4 1.2 -1.5 -1.2 -1.2
Smoking status: Current 0.0 0.0 0.1 -0.2 -0.1 0.3 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.6 3.4 3.6 -1.8 1.8 1.9 1.9
Whole body water mass 0.0 0.2 0.3 -0.6 0.3 0.6 0.5
Leg predicted mass (right) 0.1 0.4 0.5 0.5 -0.7 -0.5 -0.6
Arm fat mass (left) 0.0 0.2 0.2 0.4 -0.4 -0.4 -0.5
Number of self-reported non-cancer illnesses 1.3 2.2 2.5 -1.5 1.3 1.6 1.4
Average weekly champagne plus white wine intake 0.7 0.9 1.0 1.0 -1.0 -1.0 -0.8
Miserableness 1.9 3.3 3.7 1.9 -1.8 -1.9 -1.7
Guilty feelings 0.9 1.4 1.5 1.2 -1.2 -1.2 -1.0
Wears glasses or contact lenses 0.0 0.0 0.0 -0.1 0.2 0.2 0.1
Ever taken oral contraceptive pill 0.5 0.6 0.7 0.8 -0.7 -0.8 -0.8
Hearing aid user 0.3 0.3 0.6 -0.6 0.8 0.5 0.4
Mother’s age at death 2.5 3.1 3.4 1.6 -1.8 -1.8 -1.8
Financial situation satisfaction 3.7 4.5 5.8 2.1 -2.4 -2.0 -2.0
Tinnitus: Yes, now most or all of the time 5.0 5.9 6.7 2.6 -2.2 -2.5 -2.4
Commuting to job workplace: Public transport 1.7 2.0 2.1 -1.4 1.4 1.5 1.5
Eye problems/disorders: Glaucoma 1.8 2.1 2.5 -1.5 1.6 1.5 1.2
Medication: Blood pressure 0.1 0.2 0.2 -0.4 0.5 0.3 0.4
Pain type(s) experienced in last month: Hip pain 1.6 2.1 2.5 1.3 -1.6 -1.4 -1.4
Supplements: Fish oil (including cod liver oil) 0.0 0.1 0.1 -0.2 0.2 0.2 0.3
High cholesterol (Self-reported) 0.7 1.2 2.3 -0.9 1.5 0.9 0.9
Medication: Bendroflumethiazide 0.3 0.4 0.5 -0.6 0.7 0.6 0.7
Medication: Paracetamol 0.0 0.0 0.0 0.1 -0.2 -0.1 0.0
Medication: Lisinopril 0.8 1.1 1.3 1.1 -0.9 -1.1 -1.0
Medication: Atorvastatin 0.2 0.2 0.3 0.6 -0.5 -0.4 -0.5
Illnesses of father: High blood pressure 2.4 3.0 3.5 -1.7 1.6 1.7 1.9
Alcohol drinker status: Never 0.9 1.1 1.3 -1.0 1.2 1.0 1.1
Ever smoked 0.4 0.7 1.0 0.9 -1.0 -0.8 -0.7
Basal metabolic rate 0.1 0.3 0.4 -0.7 0.5 0.6 0.6
Leg fat percentage (left) 0.4 1.3 1.4 -1.2 1.2 1.2 1.0
Arm fat-free mass (left) 0.5 2.8 3.0 -1.7 1.5 1.7 1.7
Number of operations (self-reported) 1.1 1.6 1.9 -1.3 1.1 1.2 1.4
Average weekly beer plus cider intake 0.0 0.0 0.0 0.1 -0.1 -0.0 -0.0
Irritability 0.8 1.4 1.8 1.2 -1.0 -1.2 -1.3
Risk taking 0.0 0.1 0.1 -0.3 0.2 0.2 0.3
Ever had prostate specific antigen (PSA) test 1.6 1.8 2.2 1.5 -1.1 -1.4 -1.4
Fractured/broken bones in last 5 years 0.8 1.1 1.5 -1.1 0.7 1.1 1.2
Age started oral contraceptive pill 0.3 0.3 0.6 -0.4 0.8 0.5 0.5
Diastolic blood pressure, automated reading 4.7 14.7 15.5 -3.9 3.6 3.9 3.9
Ever depressed for a whole week 0.1 0.1 0.1 0.3 -0.3 -0.3 -0.3
Unable to work because of sickness or disability 1.0 1.3 1.6 1.2 -0.9 -1.2 -1.3
Commuting to job workplace: Cycle 0.0 0.1 0.1 -0.2 -0.2 0.2 0.3
Myopia 1.1 1.6 1.8 -1.2 1.2 1.2 1.4
Vascular/heart problems diagnosed by doctor 0.0 0.0 0.0 -0.2 0.2 0.2 0.2
Cholesterol lowering medication 0.2 0.3 0.5 -0.5 0.7 0.4 0.4
Medication: Omeprazole (e.g. Zanprol) 0.0 0.0 0.0 0.0 -0.1 -0.0 -0.0
Pain experienced in last month 0.9 1.5 1.6 1.2 -1.1 -1.3 -1.3
Supplements: Calcium 1.2 1.3 1.5 -1.1 1.1 1.1 1.2
Basal cell carcinoma (self-reported) 0.5 0.6 0.7 0.8 -0.8 -0.8 -0.7
Heart attack/myocardial infarction (self-reported) 0.0 0.0 0.1 0.3 -0.0 -0.1 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.1 -0.4 0.2 0.3 0.2
Heart disease (siblings) 2.0 2.5 2.8 1.6 -1.4 -1.6 -1.7
Alcohol drinker status: Previous 0.5 0.6 0.7 0.8 -0.7 -0.8 -0.8
Pack years of smoking 0.3 0.5 0.8 0.6 -0.9 -0.6 -0.6
Impedance of whole body 0.7 3.4 4.3 -1.7 2.1 1.8 1.8
Leg fat mass (left) 0.1 0.4 0.4 -0.6 0.6 0.6 0.5
Arm predicted mass (left) 0.5 2.4 2.7 -1.6 1.4 1.6 1.6