TWAS hub - COPS3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0610	0.0300	7.6e-03	0.037	0.010	0.013	0.018	0.027	2.5e-05	1.9e-02	9.5e-03	2.7e-03	2.4e-04
2	GTEx	Whole Blood	0.1440	0.0360	5.8e-10	0.173	NA	0.157	NA	0.160	8.7e-16	NA	2.4e-14	NA	1.3e-14
3	NTR	Blood	0.0306	0.0104	1.3e-05	0.028	0.021	0.020	0.023	0.025	1.7e-09	1.9e-07	2.9e-07	3.4e-08	1.4e-08
4	YFS	Blood	0.1688	0.0270	0.0e+00	0.216	0.186	0.213	0.210	0.216	5.9e-69	2.0e-58	6.0e-68	6.3e-67	8.3e-69

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Pulse rate, automated reading	14.2	45.9	46.8	-6.8	6.7	6.8	6.7
Heel T-Score	6.9	54.8	57.8	7.5	-6.9	-7.6	-7.6
Eye problems/disorders: Diabetes related eye disease	6.4	7.0	7.6	-2.6	2.8	2.6	2.6
Supplements: Vitamin C	6.2	7.3	7.8	-2.6	2.6	2.8	2.8
Father’s age at death	5.4	7.2	7.6	-2.8	2.5	2.7	2.8
Worry too long after embarrassment	5.4	9.1	9.6	3.0	-3.1	-3.0	-2.9
Pulse rate	5.0	8.5	9.1	-3.0	2.8	3.0	2.9
Tinnitus: Yes, now most or all of the time	5.0	5.9	6.7	2.6	-2.2	-2.5	-2.4
Diastolic blood pressure, automated reading	4.7	14.7	15.5	-3.9	3.6	3.9	3.9
Ever highly irritable/argumentative for 2 days	4.4	5.3	5.5	2.3	-2.3	-2.3	-2.2
Comparative body size at age 10	3.7	10.2	10.6	3.1	-3.1	-3.3	-3.2
Financial situation satisfaction	3.7	4.5	5.8	2.1	-2.4	-2.0	-2.0
Sensitivity / hurt feelings	3.5	6.0	6.4	2.5	-2.4	-2.5	-2.4
Diverticular disease/diverticulitis (self-reported)	3.2	3.8	4.3	-2.0	1.7	2.1	2.0
Number of full sisters	3.2	3.9	4.1	-2.0	1.9	2.0	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	3.1	4.0	4.1	-2.0	2.0	2.0	2.0
Suffer from ‘nerves’	3.0	4.7	4.8	2.2	-2.2	-2.1	-2.2
Leg pain on walking	3.0	3.7	4.2	1.9	-1.8	-2.0	-2.1
Impedance of leg (left)	2.9	14.1	15.1	-3.7	3.9	3.7	3.7
Hearing difficulty/problems with background noise	2.8	4.5	5.1	2.1	-2.3	-2.0	-2.1
Impedance of leg (right)	2.7	13.3	14.4	-3.5	3.8	3.6	3.6
Osteoarthritis (self-reported)	2.6	3.4	3.5	1.9	-1.8	-1.9	-1.8
Neuroticism score	2.5	5.3	5.6	2.4	-2.3	-2.3	-2.3
Mouth/teeth dental problems: Dentures	2.5	4.2	5.0	-2.0	2.2	2.1	2.0
Mother’s age at death	2.5	3.1	3.4	1.6	-1.8	-1.8	-1.8
Crohns Disease (2012)	2.4	3.8	4.2	2.1	-1.9	-2.0	-1.9
Heart disease (mother)	2.4	2.9	3.4	-1.7	1.9	1.7	1.7
Had major operations	2.4	2.8	3.4	1.8	-1.4	-1.9	-1.6
Illnesses of father: High blood pressure	2.4	3.0	3.5	-1.7	1.6	1.7	1.9
Ovarian Cancer	2.3	3.0	3.6	1.7	-1.9	-1.6	-1.7
Age at First Birth	2.2	3.3	3.6	1.6	-1.9	-1.8	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	2.2	2.9	3.1	1.7	-1.6	-1.7	-1.8
Comparative height size at age 10	2.2	11.8	13.0	-3.4	3.6	3.4	3.3
Illnesses of father: Heart disease	2.2	3.0	3.2	-1.8	1.8	1.7	1.7
Blood Platelet Count	2.1	23.9	26.7	4.7	-5.2	-4.8	-4.8
Frequency of depressed mood in last 2 weeks	2.1	2.9	3.3	1.6	-1.8	-1.7	-1.7
Lung FEV1/FVC ratio	2.0	10.2	11.1	-3.1	3.3	3.1	3.2
Fed-up feelings	2.0	3.7	4.1	2.0	-1.7	-2.0	-1.9
Heart disease (siblings)	2.0	2.5	2.8	1.6	-1.4	-1.6	-1.7
Neuroticism	1.9	4.6	5.0	2.2	-2.1	-2.1	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	2.6	-1.4	1.6	1.4	1.5
Miserableness	1.9	3.3	3.7	1.9	-1.8	-1.9	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.1	4.5	2.1	-1.9	-2.1	-2.1
Shortness of breath walking on level ground	1.8	2.2	2.7	1.4	-1.5	-1.4	-1.6
Eye problems/disorders: Cataract	1.8	2.0	2.1	1.4	-1.4	-1.4	-1.5
Eye problems/disorders: Glaucoma	1.8	2.1	2.5	-1.5	1.6	1.5	1.2
Alzheimer’s Disease (in father)	1.7	1.8	2.1	1.5	-1.2	-1.4	-1.4
Stomach or abdominal pain in last month	1.7	2.1	2.4	1.4	-1.4	-1.4	-1.6
Commuting to job workplace: Public transport	1.7	2.0	2.1	-1.4	1.4	1.5	1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.5	4.0	1.9	-1.7	-2.0	-2.0
Nervous feelings	1.6	3.0	3.1	1.7	-1.8	-1.7	-1.7
Had menopause	1.6	2.0	2.1	-1.4	1.5	1.4	1.4
Worrier / anxious feelings	1.6	2.9	3.1	1.7	-1.7	-1.7	-1.7
Medication: Allopurinol	1.6	2.2	2.7	1.6	-1.4	-1.5	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	3.6	-1.8	1.8	1.9	1.9
Pain type(s) experienced in last month: Hip pain	1.6	2.1	2.5	1.3	-1.6	-1.4	-1.4
Ever had prostate specific antigen (PSA) test	1.6	1.8	2.2	1.5	-1.1	-1.4	-1.4
Hair/balding pattern: Pattern 2	1.5	1.9	2.1	-1.4	1.2	1.5	1.4
Pulse wave reflection index	1.5	1.8	2.5	1.2	-1.6	-1.2	-1.3
Neuroticism (Nagel 2018)	1.4	3.4	3.8	2.0	-1.9	-1.8	-1.7
Schizophrenia (2018)	1.4	3.0	3.5	-1.7	1.9	1.6	1.7
Schizophrenia vs Biploar Disorder	1.4	1.8	1.9	-1.4	1.4	1.3	1.2
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	2.6	-1.4	1.4	1.5	1.6
Major Depression (MDD)	1.3	1.6	1.8	-1.2	1.2	1.2	1.4
Neuroticism (2016)	1.3	1.9	2.1	1.4	-1.4	-1.3	-1.4
Supplements: Glucosamine	1.3	1.7	2.1	-1.4	1.1	1.4	1.3
Medication: Ramipril	1.3	1.7	2.1	1.5	-1.0	-1.3	-1.3
Illnesses of father: None of the above (group 1)	1.3	1.6	2.4	1.2	-1.5	-1.2	-1.2
Number of self-reported non-cancer illnesses	1.3	2.2	2.5	-1.5	1.3	1.6	1.4
LDL Cholesterol	1.2	2.0	2.3	-1.5	1.4	1.3	1.4
Diabetes (mother)	1.2	1.5	1.8	1.2	-1.3	-1.1	-1.4
Had other major operations	1.2	1.4	1.6	-1.3	1.0	1.3	1.2
Peak expiratory flow (PEF)	1.2	2.7	2.9	-1.7	1.7	1.7	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.5	1.7	1.3	-0.9	-1.3	-1.3
Supplements: Calcium	1.2	1.3	1.5	-1.1	1.1	1.1	1.2
Crohns Disease (2017)	1.1	2.4	3.0	1.7	-1.4	-1.5	-1.6
Irritable Bowel Disease (IBD)	1.1	2.6	3.2	1.8	-1.6	-1.5	-1.5
Mean Putamen Volume	1.1	1.2	1.7	1.3	-1.0	-1.1	-1.0
Respiratory disease	1.1	2.4	2.8	-1.7	1.3	1.7	1.5
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	2.0	1.4	-1.1	-1.4	-1.3
Medication: Amlodipine	1.1	1.6	1.7	1.3	-1.3	-1.3	-1.2
Health satisfaction	1.1	1.4	1.6	-1.1	1.2	1.2	1.2
Number of operations (self-reported)	1.1	1.6	1.9	-1.3	1.1	1.2	1.4
Myopia	1.1	1.6	1.8	-1.2	1.2	1.2	1.4
Waist Hip Ratio (WHR)	1.0	4.4	4.8	-1.9	2.1	2.2	2.2
Chronic bronchitis/emphysema (father)	1.0	1.1	1.4	1.1	-1.0	-1.0	-1.2
Waist circumference	1.0	3.7	3.9	-2.0	1.9	2.0	1.9
Pulse wave Arterial Stiffness index	1.0	1.1	1.4	-1.2	0.9	1.1	1.0
Standing height	1.0	10.2	10.4	-3.2	3.2	3.2	3.2
Glaucoma (self-reported)	1.0	1.1	1.2	-1.1	1.1	1.1	1.0
Unable to work because of sickness or disability	1.0	1.3	1.6	1.2	-0.9	-1.2	-1.3
Ulcerative Colitis (UC)	0.9	1.8	2.1	1.4	-1.4	-1.2	-1.2
Ulcerative Colitis	0.9	1.3	1.6	1.3	-1.2	-1.0	-1.0
Hand grip strength (right)	0.9	2.4	2.5	-1.5	1.6	1.6	1.5
Falls in the last year	0.9	1.2	1.3	1.0	-1.1	-1.1	-1.1
High blood pressure (siblings)	0.9	1.3	1.7	-1.1	1.3	1.1	1.0
Chest pain or discomfort	0.9	1.2	1.6	1.0	-1.3	-1.1	-1.1
Guilty feelings	0.9	1.4	1.5	1.2	-1.2	-1.2	-1.0
Alcohol drinker status: Never	0.9	1.1	1.3	-1.0	1.2	1.0	1.1
Pain experienced in last month	0.9	1.5	1.6	1.2	-1.1	-1.3	-1.3
Depression (Nagel 2018)	0.8	1.3	1.3	1.1	-1.1	-1.1	-1.1
Worry (Nagel 2018)	0.8	1.6	1.8	1.3	-1.3	-1.2	-1.2
Sitting height	0.8	5.7	6.2	-2.4	2.5	2.4	2.3
Mouth/teeth dental problems	0.8	1.2	1.7	1.0	-1.3	-1.0	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.2	1.0	-1.1	-1.0	-0.9
Depression (self-reported)	0.8	1.0	1.2	0.9	-1.0	-1.0	-1.1
Medication: Lansoprazole	0.8	0.9	1.4	-0.8	1.2	0.8	1.0
Tense / ‘highly strung’	0.8	1.3	1.9	1.0	-1.4	-1.1	-1.1
Loud music exposure frequency	0.8	0.8	1.1	0.8	-1.1	-0.9	-0.8
Pulse wave peak to peak time	0.8	0.9	1.2	1.1	-0.8	-1.0	-0.9
Medication: Lisinopril	0.8	1.1	1.3	1.1	-0.9	-1.1	-1.0
Irritability	0.8	1.4	1.8	1.2	-1.0	-1.2	-1.3
Fractured/broken bones in last 5 years	0.8	1.1	1.5	-1.1	0.7	1.1	1.2
Intelligence (Savage-Jansen 2018)	0.7	2.2	2.6	-1.6	1.6	1.5	1.3
Height	0.7	12.7	13.5	-3.5	3.5	3.7	3.6
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	2.7	-1.6	1.5	1.6	1.5
Qualifications: A levels/AS levels or equivalent	0.7	1.6	1.7	-1.3	1.2	1.3	1.3
Hair/balding pattern: Pattern 4	0.7	1.7	1.8	1.3	-1.3	-1.3	-1.3
Number of children fathered	0.7	0.8	0.9	1.0	-0.9	-0.9	-0.8
Medication for pain relief, constipation, heartburn	0.7	1.2	1.3	-1.1	1.1	1.1	1.0
Overall health rating	0.7	1.5	1.6	1.3	-1.3	-1.2	-1.1
Back pain experienced in last month	0.7	1.0	1.1	-1.0	1.1	1.0	1.0
Breast cancer (self-reported)	0.7	0.9	1.0	0.9	-0.9	-1.0	-0.9
Average weekly champagne plus white wine intake	0.7	0.9	1.0	1.0	-1.0	-1.0	-0.8
High cholesterol (Self-reported)	0.7	1.2	2.3	-0.9	1.5	0.9	0.9
Impedance of whole body	0.7	3.4	4.3	-1.7	2.1	1.8	1.8
Bipolar Disorder or Schizophrenia	0.6	1.6	2.2	-1.2	1.5	1.1	1.2
Breast Cancer	0.6	1.5	2.0	1.0	-1.4	-1.2	-1.2
Schizophrenia (2014)	0.6	1.4	2.1	-1.1	1.4	1.1	1.0
Angina	0.6	0.8	0.8	0.9	-0.9	-0.9	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.0	1.0	-0.7	-1.0	-1.0
Allergy	0.6	1.5	2.0	-1.1	1.4	1.2	1.1
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.4	0.7	-1.2	-0.8	-0.8
Medication: Ibuprofen	0.6	0.7	1.0	0.8	-1.0	-0.8	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	0.7	-0.8	0.9	0.8	0.8
Average weekly red wine intake	0.6	0.8	1.0	1.0	-0.8	-1.0	-0.9
Mineral and other dietary supplements	0.6	0.8	0.8	0.8	-0.9	-0.9	-0.9
HDL Cholesterol	0.5	0.8	1.0	0.9	-0.9	-0.9	-1.0
Hair Pigment	0.5	14.9	16.0	-4.0	3.9	3.8	3.8
Hearing difficulty/problems: Yes	0.5	0.8	1.2	0.9	-0.8	-0.9	-1.1
Medication: Metformin	0.5	0.7	0.8	-0.8	0.7	0.9	0.8
Townsend deprivation index at recruitment	0.5	0.7	0.9	0.8	-0.9	-0.8	-0.9
Taking other prescription medications	0.5	0.8	1.2	-0.8	1.1	0.9	0.7
Serious illness, injury or assault to yourself	0.5	0.7	0.8	-0.7	0.9	0.8	0.9
Number of incorrect matches in round	0.5	0.8	1.0	0.9	-0.7	-1.0	-0.9
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	0.8	0.8	-0.9	-0.8	-0.7
Medication: Simvastatin	0.5	0.7	1.3	-0.8	1.1	0.7	0.8
Number of full brothers	0.5	0.7	0.9	0.8	-0.9	-0.8	-0.7
Qualifications: College or University degree	0.5	1.5	1.5	-1.2	1.1	1.2	1.2
Angina (self-reported)	0.5	0.7	0.7	0.9	-0.8	-0.8	-0.8
Medication: Omeprazole	0.5	0.6	0.8	0.7	-0.9	-0.7	-0.7
Arm predicted mass (right)	0.5	2.5	2.7	-1.6	1.4	1.6	1.6
Ever had bowel cancer screening	0.5	0.6	0.9	-0.7	0.9	0.7	0.7
Commuting to job workplace: Walk	0.5	0.5	0.6	-0.8	0.6	0.7	0.8
Ever taken oral contraceptive pill	0.5	0.6	0.7	0.8	-0.7	-0.8	-0.8
Arm fat-free mass (left)	0.5	2.8	3.0	-1.7	1.5	1.7	1.7
Basal cell carcinoma (self-reported)	0.5	0.6	0.7	0.8	-0.8	-0.8	-0.7
Alcohol drinker status: Previous	0.5	0.6	0.7	0.8	-0.7	-0.8	-0.8
Arm predicted mass (left)	0.5	2.4	2.7	-1.6	1.4	1.6	1.6
Alzheimer’s Disease (in mother)	0.4	0.4	0.6	-0.8	0.5	0.7	0.6
Systolic Blood Pressure	0.4	2.2	2.8	1.6	-1.7	-1.4	-1.3
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.7	-0.7	0.6	0.7	0.8
Ever had hysterectomy (womb removed)	0.4	0.5	0.7	-0.8	0.7	0.6	0.6
Average weekly fortified wine intake	0.4	0.5	0.6	-0.7	0.6	0.7	0.7
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.1	0.9	-1.0	-0.9	-0.8
Medication: Atenolol	0.4	0.5	0.9	-0.7	0.9	0.6	0.6
Hair/balding pattern: Pattern 3	0.4	0.6	0.9	-0.7	0.9	0.7	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.5	0.7	-0.6	-0.7	-0.7
Gout (self-reported)	0.4	0.6	0.9	0.9	-0.7	-0.7	-0.6
Arm fat-free mass (right)	0.4	2.0	2.3	-1.5	1.2	1.5	1.4
Smoking status: Previous	0.4	0.6	0.8	0.8	-0.8	-0.9	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	0.8	-0.8	0.7	0.8	0.9
Ever smoked	0.4	0.7	1.0	0.9	-1.0	-0.8	-0.7
Leg fat percentage (left)	0.4	1.3	1.4	-1.2	1.2	1.2	1.0
Prostate Cancer	0.3	0.5	0.5	0.7	-0.6	-0.7	-0.7
Coronary Artery Disease (CAD)	0.3	0.4	0.5	-0.4	0.7	0.7	0.7
Smoking Status	0.3	0.7	1.1	0.8	-1.0	-0.7	-0.6
Allergy or Eczema	0.3	0.7	0.9	0.8	-1.0	-0.8	-0.7
Hand grip strength (left)	0.3	0.7	0.9	-0.8	0.9	0.9	0.8
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.4	-0.6	0.6	0.5	0.6
Age when periods started (menarche)	0.3	0.6	0.9	0.9	-0.7	-0.7	-0.7
Diabetes (self-reported)	0.3	0.4	0.5	-0.7	0.5	0.7	0.7
Illnesses of siblings	0.3	0.5	0.8	-0.6	0.6	0.6	0.9
Arm fat percentage (right)	0.3	1.0	1.2	1.0	-1.0	-1.0	-1.1
Prospective memory result	0.3	0.4	0.4	0.6	-0.6	-0.6	-0.6
Lung cancer (father)	0.3	0.3	0.4	0.5	-0.4	-0.7	-0.6
Headache pain in last month	0.3	0.5	0.6	-0.7	0.7	0.8	0.7
Leg fat percentage (right)	0.3	1.0	1.1	-1.0	1.1	1.1	0.9
Medication: Blood pressure	0.3	0.6	0.8	0.9	-0.7	-0.8	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	0.7	-0.8	0.7	0.7	0.7
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.6	-0.5	0.8	0.6	0.6
Friendships satisfaction	0.3	0.3	0.4	-0.5	0.6	0.6	0.6
Medication: Gliclazide	0.3	0.3	0.4	-0.6	0.4	0.6	0.5
Hearing aid user	0.3	0.3	0.6	-0.6	0.8	0.5	0.4
Medication: Bendroflumethiazide	0.3	0.4	0.5	-0.6	0.7	0.6	0.7
Age started oral contraceptive pill	0.3	0.3	0.6	-0.4	0.8	0.5	0.5
Pack years of smoking	0.3	0.5	0.8	0.6	-0.9	-0.6	-0.6
Alzheimer’s Disease (including proxy)	0.2	0.3	0.3	0.6	-0.4	-0.5	-0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.5	-0.7	0.7	0.6	0.4
Body Mass Index (BMI) (2010)	0.2	0.2	0.4	-0.4	0.6	0.4	0.4
Lupus	0.2	0.3	0.5	-0.6	0.4	0.7	0.4
Blood Eosinophil Count	0.2	1.7	2.0	1.4	-1.1	-1.3	-1.3
BMI	0.2	1.4	1.6	1.1	-1.2	-1.1	-1.3
Chronotype (morning person)	0.2	0.4	0.4	0.6	-0.7	-0.6	-0.6
Qualifications: CSEs or equivalent	0.2	0.3	0.7	0.4	-0.9	-0.4	-0.3
Past tobacco smoking	0.2	0.3	0.4	-0.6	0.6	0.6	0.4
Alcohol usually taken with meals	0.2	0.3	0.4	-0.5	0.4	0.6	0.6
Forced vital capacity (FVC)	0.2	0.6	0.7	-0.9	0.7	0.9	0.7
Pain all over the body in last month	0.2	0.2	0.3	0.4	-0.6	-0.3	-0.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.4	-0.6	0.4	0.6	0.5
Trunk fat-free mass	0.2	1.3	1.5	-1.2	0.9	1.2	1.2
Happiness	0.2	0.2	0.4	-0.3	0.6	0.4	0.4
Medication: Cholesterol lowering	0.2	0.4	0.6	-0.5	0.8	0.6	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	0.8	-0.9	0.7	0.9	0.8
Trunk predicted mass	0.2	1.3	1.5	-1.2	0.9	1.2	1.2
Exposure to tobacco smoke outside home	0.2	0.3	0.4	0.6	-0.6	-0.5	-0.5
Eye problems/disorders: None of the above	0.2	0.2	0.3	-0.4	0.3	0.5	0.6
Medication: Seretide 50 evohaler	0.2	0.2	0.3	-0.5	0.4	0.4	0.4
Age at last live birth	0.2	0.3	0.3	0.5	-0.6	-0.4	-0.5
Medication: Aspirin	0.2	0.3	0.4	0.6	-0.4	-0.6	-0.6
Knee pain experienced in last month	0.2	0.3	0.4	-0.7	0.5	0.5	0.6
Illnesses of siblings: Diabetes	0.2	0.3	0.5	-0.5	0.7	0.6	0.4
Arm fat percentage (left)	0.2	1.0	1.1	1.0	-0.9	-1.0	-1.1
Long-standing illness, disability or infirmity	0.2	0.3	0.4	0.6	-0.4	-0.5	-0.6
Asthma (self-reported)	0.2	0.3	0.4	-0.7	0.4	0.6	0.5
Medication: Atorvastatin	0.2	0.2	0.3	0.6	-0.5	-0.4	-0.5
Cholesterol lowering medication	0.2	0.3	0.5	-0.5	0.7	0.4	0.4
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	0.6	-0.4	-0.5	-0.3
Reaction Time	0.1	0.3	0.4	-0.5	0.4	0.6	0.5
Primary Biliary Cirrhosis	0.1	0.1	0.3	-0.1	0.5	0.3	0.2
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	0.4	-0.3	-0.2	-0.5
Blood Red Count	0.1	0.5	0.8	-0.9	0.5	0.8	0.4
Cardiovascular Disease	0.1	0.3	0.4	0.6	-0.5	-0.6	-0.6
Hypothyroidism (self reported)	0.1	0.2	0.3	-0.5	0.4	0.5	0.3
Lung FVC	0.1	0.5	0.6	0.6	-0.8	-0.6	-0.8
Tanning	0.1	1.6	1.7	1.2	-1.3	-1.3	-1.2
Number of treatments/medications taken	0.1	0.2	0.2	0.5	-0.3	-0.4	-0.5
Relative age of first facial hair	0.1	0.2	0.3	0.4	-0.5	-0.4	-0.5
Medication for hormone replacement therapy	0.1	0.1	0.2	0.4	-0.3	-0.4	-0.2
Medication: Co-codamol	0.1	0.2	0.2	-0.4	0.3	0.5	0.4
Pack years adult smoking proportion	0.1	0.2	0.4	0.3	-0.6	-0.3	-0.2
Trunk fat percentage	0.1	0.3	0.5	-0.5	0.7	0.5	0.4
Maternal smoking around birth	0.1	0.1	0.3	-0.3	0.5	0.3	0.3
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	-0.5	-0.1	0.4	0.4
Multivitamins +/- minerals	0.1	0.1	0.2	0.4	-0.4	-0.3	-0.3
Body mass index (BMI)	0.1	0.5	0.6	0.6	-0.7	-0.7	-0.8
Trunk fat mass	0.1	0.4	0.5	-0.6	0.7	0.6	0.5
Financial difficulties in last 2 years	0.1	0.2	0.3	-0.4	0.4	0.4	0.5
Heart attack	0.1	0.2	0.3	0.5	-0.2	-0.4	-0.4
Weight	0.1	0.6	0.7	-0.8	0.8	0.8	0.7
Alcohol intake versus 10 years previously	0.1	0.1	0.2	-0.4	0.4	0.4	0.2
Asthma	0.1	0.3	0.3	-0.6	0.4	0.6	0.5
Medication: Paracetamol	0.1	0.1	0.2	0.4	-0.4	-0.4	-0.3
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.1	0.4	-0.2	-0.4	-0.3
Forced vital capacity (FVC), Best measure	0.1	0.5	0.7	-0.8	0.6	0.8	0.6
Body fat percentage	0.1	0.3	0.5	-0.6	0.7	0.6	0.4
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.5	0.3	0.4	0.3
Neck or shoulder pain in last month	0.1	0.1	0.2	-0.5	0.2	0.4	0.4
Migraine (self-reported)	0.1	0.1	0.1	-0.3	0.0	0.3	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.2	0.4	-0.2	-0.5	-0.4
Leg fat mass (right)	0.1	0.2	0.2	-0.5	0.5	0.5	0.4
Alcohol intake frequency.	0.1	0.1	0.2	0.3	-0.4	-0.3	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.3	-0.2	-0.4	-0.5
Hypertension (Self-reported)	0.1	0.2	0.2	0.4	-0.4	-0.4	-0.4
Leg fat-free mass (right)	0.1	0.3	0.4	0.5	-0.6	-0.5	-0.6
Mood swings	0.1	0.3	0.4	0.7	-0.3	-0.5	-0.5
Osteoporosis (self-reported)	0.1	0.1	0.1	-0.3	0.2	0.3	0.4
Medication: Aspirin	0.1	0.2	0.2	0.5	-0.3	-0.5	-0.4
Leg predicted mass (right)	0.1	0.4	0.5	0.5	-0.7	-0.5	-0.6
Medication: Blood pressure	0.1	0.2	0.2	-0.4	0.5	0.3	0.4
Basal metabolic rate	0.1	0.3	0.4	-0.7	0.5	0.6	0.6
Ever depressed for a whole week	0.1	0.1	0.1	0.3	-0.3	-0.3	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.1	-0.4	0.2	0.3	0.2
Leg fat mass (left)	0.1	0.4	0.4	-0.6	0.6	0.6	0.5
Bipolar Disorder (2018)	0.0	0.0	0.1	0.2	0.0	-0.3	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	-0.1	0.0	0.0	0.2
Fasting Glucose	0.0	0.0	0.0	0.1	-0.2	-0.1	0.0
HbA1C	0.0	0.0	0.0	-0.1	-0.1	0.1	0.2
Rheumatoid Arthritis	0.0	0.0	0.0	0.0	0.0	0.1	0.1
Triglycerides	0.0	0.0	0.1	0.2	-0.2	-0.0	-0.2
Blood White Count	0.0	0.0	0.0	0.1	-0.2	-0.0	-0.1
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.0	0.2	-0.1	0.1	0.0
Average weekly spirits intake	0.0	0.0	0.0	0.0	-0.1	0.1	0.0
Systolic blood pressure, automated reading	0.0	0.0	0.0	-0.1	-0.1	0.1	0.2
Vitamin and mineral supplements	0.0	0.0	0.0	-0.0	0.1	-0.0	-0.0
Supplements: Zinc	0.0	0.0	0.1	-0.3	0.1	0.2	0.2
Diabetes (father)	0.0	0.0	0.0	-0.1	0.1	0.1	0.1
Severe depression (siblings)	0.0	0.0	0.0	-0.0	0.2	0.0	0.1
Leg fat-free mass (left)	0.0	0.2	0.3	0.4	-0.5	-0.4	-0.5
Current tobacco smoking	0.0	0.0	0.0	-0.0	-0.2	0.1	0.1
Relative age voice broke	0.0	0.1	0.1	0.2	-0.3	-0.2	-0.3
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.1	-0.2	-0.2	0.1	0.1
High blood pressure	0.0	0.1	0.1	0.3	-0.3	-0.3	-0.3
Medication: Levothyroxine sodium	0.0	0.0	0.0	-0.1	0.1	0.2	-0.0
High blood pressure (mother)	0.0	0.0	0.1	0.1	-0.3	-0.2	-0.0
Leg predicted mass (left)	0.0	0.3	0.3	0.5	-0.6	-0.5	-0.5
Qualifications: None of the above	0.0	0.0	0.0	0.0	0.2	-0.0	-0.1
Fluid intelligence score	0.0	0.0	0.1	-0.1	-0.0	-0.1	-0.2
Impedance of arm (right)	0.0	0.0	0.1	0.2	0.1	-0.2	-0.1
Hip circumference	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.2
Time employed in main current job	0.0	0.0	0.1	-0.1	0.3	0.1	0.1
Number of live births	0.0	0.0	0.1	0.1	-0.3	-0.2	-0.2
Noisy workplace	0.0	0.0	0.1	-0.0	-0.3	-0.0	-0.1
Illnesses of mother	0.0	0.0	0.1	0.2	-0.2	-0.2	-0.2
Impedance of arm (left)	0.0	0.0	0.0	0.2	0.2	-0.2	-0.1
Arm fat mass (right)	0.0	0.1	0.1	0.3	-0.2	-0.3	-0.3
Length of working week for main job	0.0	0.0	0.1	0.2	0.1	-0.2	-0.2
Exposure to tobacco smoke at home	0.0	0.0	0.1	0.2	-0.2	-0.1	-0.0
Breastfed as a baby	0.0	0.0	0.0	0.1	-0.1	-0.1	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.1	-0.2	0.3	0.2	0.1
Birth weight of first child	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.1
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.1	0.1	0.0	-0.3	-0.2
Blood clot in the leg (DVT)	0.0	0.0	0.0	-0.2	-0.0	0.1	-0.0
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.1	-0.3	0.1	0.2	0.2
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.1	-0.3	0.3	0.3	0.1
Birth weight	0.0	0.1	0.1	0.3	-0.2	-0.3	-0.1
Wheeze or whistling in the chest in last year	0.0	0.0	0.0	-0.0	0.0	0.0	-0.0
Age at first live birth	0.0	0.0	0.1	-0.1	0.3	0.1	0.1
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	-0.1	0.1	0.1	0.1
Mean time to correctly identify matches	0.0	0.0	0.1	0.1	-0.0	-0.1	-0.2
Whole body fat mass	0.0	0.2	0.3	-0.4	0.5	0.4	0.3
Family relationship satisfaction	0.0	0.0	0.1	0.3	0.0	-0.3	-0.0
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.0	0.1	0.1	-0.2	-0.1
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.0	-0.0	0.1	0.0	-0.0
Whole body fat-free mass	0.0	0.3	0.4	-0.6	0.4	0.6	0.5
Loneliness, isolation	0.0	0.0	0.0	-0.2	0.0	0.1	0.2
Diabetes diagnosed by doctor	0.0	0.0	0.0	-0.2	0.1	0.2	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.0	-0.0	-0.0	-0.0	-0.1
Qualifications: nursing, teaching	0.0	0.1	0.2	-0.1	0.1	0.2	0.4
Medication for cholesterol	0.0	0.0	0.0	-0.1	-0.0	0.2	0.1
Smoking status: Current	0.0	0.0	0.1	-0.2	-0.1	0.3	0.3
Whole body water mass	0.0	0.2	0.3	-0.6	0.3	0.6	0.5
Arm fat mass (left)	0.0	0.2	0.2	0.4	-0.4	-0.4	-0.5
Wears glasses or contact lenses	0.0	0.0	0.0	-0.1	0.2	0.2	0.1
Supplements: Fish oil (including cod liver oil)	0.0	0.1	0.1	-0.2	0.2	0.2	0.3
Medication: Paracetamol	0.0	0.0	0.0	0.1	-0.2	-0.1	0.0
Average weekly beer plus cider intake	0.0	0.0	0.0	0.1	-0.1	-0.0	-0.0
Risk taking	0.0	0.1	0.1	-0.3	0.2	0.2	0.3
Commuting to job workplace: Cycle	0.0	0.1	0.1	-0.2	-0.2	0.2	0.3
Vascular/heart problems diagnosed by doctor	0.0	0.0	0.0	-0.2	0.2	0.2	0.2
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.0	0.0	-0.1	-0.0	-0.0
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.1	0.3	-0.0	-0.1	-0.2

Hub : Genes

COPS3

Models

Trait associations