Hub : Genes

PLD6

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1000 0.0370 2.1e-03 0.070 -0.002 0.053 0.067 0.072 7.0e-09 7.0e-01 5.0e-07 1.3e-08 4.2e-09
2 GTEx Cells EBV-transformed lymphocytes 0.3420 0.1280 1.8e-03 0.037 NA 0.088 NA 0.085 2.3e-02 NA 8.4e-04 NA 1.0e-03
3 GTEx Heart Left Ventricle 0.0898 0.0393 5.3e-03 0.054 NA 0.029 NA 0.046 7.9e-04 NA 1.1e-02 NA 1.8e-03
4 GTEx Testis 0.1730 0.0710 3.3e-03 0.067 NA 0.010 NA 0.005 6.7e-04 NA 1.2e-01 NA 1.9e-01
5 NTR Blood 0.0254 0.0083 2.8e-06 0.021 0.021 0.027 0.024 0.020 1.6e-07 1.8e-07 3.5e-09 3.1e-08 4.5e-07
6 ROSMAP Brain Pre-frontal Cortex 0.1265 0.0400 8.5e-06 0.010 0.038 0.049 0.048 0.027 1.7e-02 9.4e-06 6.3e-07 8.1e-07 1.9e-04
7 YFS Blood 0.1063 0.0209 0.0e+00 0.067 0.107 0.104 0.111 0.100 4.7e-21 3.4e-33 4.1e-32 3.0e-34 6.4e-31
8 TCGA Liver Hepatocellular Carcinoma 0.1150 0.0750 3.6e-03 0.006 0.035 0.078 NA 0.037 1.6e-01 8.8e-03 1.6e-04 NA 7.4e-03
9 TCGA Soft Tissue Sarcoma 0.1940 0.1230 8.1e-03 0.012 0.023 0.039 NA 0.029 6.3e-02 1.6e-02 2.2e-03 NA 7.3e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.6 0.9 3.2 1.8 0.1 -0.0 -1.6 0.4 -1.1 0.6 0.4 0.8
Bipolar Disorder or Schizophrenia 0.5 1.2 5.7 0.8 -0.4 -0.7 -2.4 -1.4 0.1 -1.4 -0.2 -0.2
Depressed Affect (Nagel 2018) 0.7 1.4 4.1 -0.8 -1.1 -0.7 -2.0 -1.8 1.1 -1.0 -0.4 -1.0
Depression (Nagel 2018) 0.2 0.3 0.8 -0.7 0.9 0.6 -0.1 -0.5 0.6 -0.3 0.1 0.5
Intelligence (Savage-Jansen 2018) 0.3 1.0 4.7 0.6 -0.2 -0.2 1.4 -0.0 2.2 0.7 -1.0 -0.1
Neuroticism (Nagel 2018) 0.4 0.9 1.9 -1.2 -0.8 -0.3 -1.0 -1.4 1.0 -0.5 0.8 -1.2
Schizophrenia (2018) 0.9 1.9 5.2 -0.4 -0.6 -0.9 -1.7 -2.1 1.2 -2.3 -0.3 -1.1
Schizophrenia vs Biploar Disorder 1.2 1.6 7.0 -1.2 -1.0 -0.2 0.6 -0.7 2.6 -1.7 -0.8 -0.6
Worry (Nagel 2018) 0.4 0.9 4.9 -2.2 -0.6 -0.2 0.3 -1.3 0.5 -0.5 0.0 -0.9
Alzheimer’s Disease (in mother) 0.6 0.7 2.6 -1.0 0.7 -0.7 -0.3 0.3 -1.2 0.1 -1.6 -0.2
Alzheimer’s Disease (in father) 1.0 1.1 5.4 -1.1 -0.4 -0.1 -1.1 -0.1 -2.3 -0.9 -0.7 0.9
Alzheimer’s Disease (including proxy) 0.9 1.2 4.9 -1.6 0.3 -0.5 -0.4 0.6 -2.2 0.1 -1.5 0.7
Crohns Disease (2017) 0.9 2.1 5.1 1.6 1.2 -0.2 0.5 2.3 1.4 1.7 2.0 -0.7
Irritable Bowel Disease (IBD) 0.9 2.0 6.8 2.1 1.1 0.0 -0.3 1.9 0.7 1.2 2.6 -0.1
Ulcerative Colitis (UC) 0.5 1.0 4.3 1.4 1.0 0.1 -0.8 0.9 -0.2 0.2 2.1 0.6
Major Depression (MDD) 0.6 0.8 3.2 0.3 -0.3 -0.2 0.6 -0.0 1.7 -0.2 -0.5 -1.8
Reaction Time 0.4 0.8 2.2 0.8 -0.5 -0.7 -1.3 -1.0 0.4 -1.5 0.6 -0.7
Verbal and Numeric Reasoning (VNR) 0.3 0.7 2.5 -0.2 -0.2 -0.7 1.6 1.1 1.0 0.4 -0.9 0.1
Breast Cancer 0.3 0.8 2.1 1.1 0.4 1.2 -0.2 0.7 -1.0 0.3 0.7 1.4
Ovarian Cancer 2.5 3.3 8.7 -0.3 0.4 3.0 1.8 2.1 -2.0 1.8 0.2 2.4
Prostate Cancer 0.7 0.9 2.5 -1.4 -0.2 1.3 -0.4 -1.6 0.1 -1.4 -0.3 0.3
Age at First Birth 0.4 0.5 1.7 0.1 0.9 1.0 0.2 -0.0 -0.9 -0.3 1.3 0.4
Bipolar Disorder (2011) 0.4 0.4 3.7 0.0 0.0 0.0 0.0 0.0 0.0 1.9 -0.1 0.2
Body Mass Index (BMI) (2010) 0.8 1.1 2.7 0.3 -1.0 -1.5 -0.0 1.0 -1.0 1.6 -1.3 0.5
Coronary Artery Disease (CAD) 2.1 2.5 6.4 0.4 -1.9 -2.5 -2.2 -1.8 -0.7 -1.0 -0.3 -1.6
Crohns Disease (2012) 1.2 2.0 5.6 2.4 1.2 0.7 -0.3 1.7 -0.1 1.4 2.3 0.5
Mean Putamen Volume 1.2 1.4 4.4 1.8 0.7 0.1 0.8 2.1 -0.8 1.1 1.0 0.9
Fasting Glucose 0.3 0.4 1.5 -1.2 0.2 -1.1 -0.1 0.1 -0.6 -0.0 -0.6 -0.0
HbA1C 0.7 0.8 3.9 -1.2 -0.2 0.5 2.0 0.8 0.4 0.8 0.3 -0.5
HDL Cholesterol 0.4 0.7 2.0 -0.1 1.4 1.2 1.1 0.7 -0.1 0.2 0.6 0.6
LDL Cholesterol 0.7 1.1 2.7 -0.7 -1.2 -0.2 1.6 0.2 1.3 0.7 -0.8 -1.5
Lupus 0.7 1.0 3.7 -0.9 -0.6 -1.9 -0.1 0.7 -0.6 0.3 -1.2 -1.4
Neuroticism (2016) 0.8 1.1 2.9 0.2 -1.7 -0.6 -1.4 -0.9 1.1 -0.5 0.6 -1.5
Primary Biliary Cirrhosis 0.2 0.2 0.8 0.0 -0.9 0.1 0.5 0.6 0.7 -0.0 0.4 -0.6
Rheumatoid Arthritis 0.2 0.3 0.6 0.7 0.6 0.8 -0.2 0.3 0.4 -0.3 0.7 0.2
Schizophrenia (2014) 1.0 2.3 5.2 -1.1 -0.3 -1.5 -1.6 -1.8 1.4 -2.3 0.2 -2.0
Triglycerides 0.3 0.5 2.1 -0.3 -1.0 -0.3 0.3 0.5 -1.4 0.5 -0.4 0.5
Type 2 Diabetes (T2D) (2012) 1.0 1.2 3.5 1.1 -0.2 0.4 0.9 1.1 -0.7 1.9 0.0 1.8
Ulcerative Colitis 1.0 1.4 4.3 2.0 -0.1 0.7 0.1 1.6 -0.1 1.1 2.1 0.6
Blood Eosinophil Count 0.1 0.8 2.8 -0.4 -1.7 -0.2 0.1 0.7 1.3 1.2 0.5 -0.1
Blood Platelet Count 0.3 3.8 17.5 0.8 0.4 2.2 0.6 1.4 1.1 1.2 4.2 2.5
Blood Red Count 0.4 3.6 14.5 -1.9 0.4 1.8 0.1 -3.8 1.4 -2.9 0.1 0.8
Blood White Count 0.4 2.6 9.4 -1.2 -1.3 1.6 1.9 0.3 3.1 1.0 1.9 -0.3
Heel T-Score 2.2 17.8 44.0 1.9 2.7 4.8 3.9 4.8 -3.2 4.6 3.5 6.6
BMI 0.3 1.7 4.6 -0.9 0.3 -1.4 -1.8 -2.0 -0.7 -2.1 -0.0 -0.4
Height 0.1 2.3 12.2 0.4 -0.4 0.4 0.9 -0.5 3.5 -1.2 -2.3 -0.3
Waist Hip Ratio (WHR) 1.6 7.0 22.8 -2.0 -3.8 -2.4 1.3 0.4 3.2 1.9 -0.5 -4.8
Systolic Blood Pressure 0.8 3.8 8.9 0.9 -1.1 2.5 3.0 2.7 -1.0 2.5 1.4 0.3
Smoking Status 0.9 2.2 5.9 0.4 1.6 -0.4 -0.8 1.8 -2.4 2.3 -0.8 1.0
Allergy or Eczema 0.3 0.9 3.7 -1.9 -1.1 0.4 1.2 -0.3 -0.6 0.7 -0.5 -0.1
Cardiovascular Disease 0.7 2.3 6.2 0.1 -1.2 1.4 2.5 1.9 1.1 2.0 1.3 -0.7
Hypothyroidism (self reported) 0.8 1.8 6.0 -0.5 -2.5 -0.0 1.6 -0.0 2.3 0.2 -1.5 -0.1
Respiratory disease 0.7 1.5 5.1 -0.9 0.0 -2.3 -1.4 -1.6 -0.4 -0.7 -1.3 -1.0
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.8 -0.7 -0.6 0.6 -0.3 -0.9 0.0 -0.8 -0.1 0.8
Lung FEV1/FVC ratio 1.0 4.9 17.7 -0.6 -4.2 -0.6 0.2 -1.2 3.6 0.4 -2.1 -2.6
Lung FVC 0.6 2.8 8.1 0.1 -0.9 0.5 2.5 2.8 -1.1 2.4 -0.6 1.8
Neuroticism 0.2 0.5 1.7 -1.1 -1.3 0.3 -0.0 -0.2 0.7 0.2 0.6 -0.6
Chronotype (morning person) 0.6 1.3 5.9 1.0 2.4 -0.1 0.2 0.2 0.5 0.3 2.1 -0.6
Hair Pigment 0.1 3.0 8.5 0.6 -1.1 -1.1 -2.9 -2.1 -1.2 -2.1 -2.5 0.3
Tanning 0.1 1.5 3.4 -1.3 1.6 0.6 0.0 -0.2 -1.4 -0.7 -1.8 1.9
Hand grip strength (left) 1.0 2.7 7.6 -2.6 -2.2 -1.0 1.4 -0.7 0.9 0.2 -2.8 -0.3
Number of treatments/medications taken 0.2 0.3 1.2 -1.1 -0.5 -0.7 0.6 -0.1 0.4 0.2 -0.4 -0.5
Average weekly spirits intake 1.0 1.3 3.7 -1.9 -1.0 -0.5 -0.6 -1.4 -1.0 -1.1 -1.3 -0.0
Sensitivity / hurt feelings 0.2 0.4 1.0 -0.6 -0.9 0.3 -0.4 -0.1 0.8 1.0 0.8 0.3
Frequency of depressed mood in last 2 weeks 0.5 0.7 2.5 -0.6 0.8 0.5 -1.6 -1.2 -0.1 -0.5 -0.5 1.1
Hearing difficulty/problems: Yes 0.1 0.1 0.3 -0.5 0.2 -0.3 0.2 -0.3 -0.1 -0.1 0.1 -0.4
Relative age of first facial hair 0.2 0.3 0.9 -0.7 -1.0 -0.0 0.3 0.3 0.0 0.8 0.6 -0.5
Other serious medical condition/disability diagnosed by doctor 2.0 2.6 9.3 -1.5 0.3 -0.7 -1.4 -3.0 1.0 -2.5 -1.3 -0.7
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.8 1.3 0.9 1.3 -0.1 0.2 -0.5 -0.3 0.0 0.9
Ever had hysterectomy (womb removed) 0.4 0.5 2.2 0.7 -1.5 -0.2 0.4 -0.1 0.9 0.8 0.2 -0.1
Systolic blood pressure, automated reading 0.3 1.0 2.9 0.8 -0.7 1.7 1.7 0.8 -0.8 0.6 0.3 -0.0
Eye problems/disorders: Diabetes related eye disease 3.7 4.0 9.0 -0.5 -1.6 -2.7 -3.0 -2.6 0.2 -2.2 -2.1 -1.1
Angina 0.8 1.0 3.2 -0.6 -1.8 -1.0 -1.4 -0.8 0.1 -1.3 0.4 0.3
Medication for hormone replacement therapy 1.9 2.1 5.7 0.8 1.6 2.0 1.9 1.2 -0.0 1.0 -0.3 2.4
Vitamin and mineral supplements 0.4 0.5 1.2 -0.7 0.3 -0.8 -0.3 -1.1 1.0 -0.8 -0.5 0.2
Supplements: Zinc 0.7 0.8 2.2 0.7 0.0 -1.4 -0.4 0.5 -0.5 1.5 0.3 -1.3
Medication: Co-codamol 1.0 1.1 5.9 0.1 0.2 0.3 -1.1 -1.5 -0.0 -2.4 0.6 -0.2
Medication: Metformin 0.3 0.4 1.5 -0.8 -1.2 0.5 0.0 -0.6 -0.3 -0.3 -0.7 0.8
Diabetes (father) 0.7 0.9 2.7 -1.7 -0.2 0.3 0.9 -0.4 1.6 -1.2 -0.6 -0.1
Diabetes (mother) 0.6 0.7 2.5 1.4 -0.2 0.8 0.2 0.7 0.5 0.7 1.6 0.3
Severe depression (siblings) 1.2 1.3 3.4 1.4 -0.3 0.2 1.1 1.8 1.2 1.9 0.5 0.3
Pack years adult smoking proportion 0.4 0.6 1.7 0.6 0.8 0.2 -1.3 -0.2 -0.1 -0.8 1.3 -0.5
Impedance of leg (right) 0.7 3.5 8.0 2.0 -2.8 -1.4 1.0 1.5 1.2 2.7 -1.5 -1.9
Leg fat-free mass (left) 0.3 1.5 3.8 -1.9 1.5 -0.7 -0.6 -1.4 1.0 -1.9 -0.2 -0.6
Trunk fat percentage 0.3 1.3 3.9 -0.5 -0.8 -2.0 -0.1 -0.9 1.2 -1.3 0.0 -1.7
Hand grip strength (right) 1.1 2.9 7.6 -2.7 -1.8 -1.1 1.8 -0.7 1.3 0.8 -2.8 -1.0
Townsend deprivation index at recruitment 0.5 0.7 2.8 -1.1 0.8 1.7 1.0 -0.1 -0.9 -0.4 0.0 0.3
Current tobacco smoking 0.7 1.1 3.1 -0.6 0.8 0.2 -1.6 -0.0 -1.8 -0.6 -1.5 0.9
Average weekly fortified wine intake 0.3 0.4 1.8 -0.1 -1.4 0.1 -0.1 -0.0 -0.4 -0.3 0.5 -1.1
Maternal smoking around birth 0.6 0.9 2.0 1.0 -1.0 -1.0 -0.1 0.7 1.0 0.7 0.8 -1.4
Fed-up feelings 0.7 1.3 4.6 -0.2 -2.1 -0.3 0.1 0.5 1.9 1.6 0.9 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 3.0 -1.7 0.7 0.7 -0.3 -0.4 0.1 -0.2 0.1 0.7
Relative age voice broke 0.3 0.4 1.6 -1.3 0.5 0.2 0.6 0.4 -1.0 0.4 -0.6 -0.2
Taking other prescription medications 0.7 1.1 6.2 0.5 -0.6 -0.4 1.1 0.5 2.5 0.6 0.2 -0.8
Age when periods started (menarche) 0.5 1.1 4.3 -2.1 -1.5 0.5 1.2 0.9 0.4 1.0 0.3 0.2
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 1.6 -1.2 0.7 0.8 0.6 -0.1 1.2 -0.7 -1.1 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.2 8.4 -0.4 0.8 2.2 2.9 1.5 0.2 2.8 0.8 2.1
Tinnitus: Yes, but not now, but have in the past 2.5 2.7 8.7 -0.3 1.4 0.7 2.4 2.4 -0.3 3.0 -0.8 0.7
Qualifications: CSEs or equivalent 0.3 0.4 1.3 -1.2 0.1 0.3 0.5 0.8 0.2 0.9 0.5 -0.3
Serious illness, injury or assault to yourself 0.8 0.9 2.3 -1.5 -0.8 -1.2 -1.0 -0.5 -0.5 0.1 -1.4 -0.5
High blood pressure 0.4 1.0 2.7 0.6 -0.8 0.6 1.6 1.5 -0.2 1.4 1.1 -0.4
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.6 0.4 -0.7 0.9 1.1 0.1 -0.2 1.3 0.5 0.6
Multivitamins +/- minerals 0.9 1.1 2.6 1.1 0.1 1.5 1.2 1.0 -0.6 1.6 1.0 0.5
Stomach or abdominal pain in last month 0.8 0.9 2.8 -0.2 0.5 -0.1 0.9 0.3 1.6 0.7 1.7 -1.2
Supplements: Glucosamine 1.1 1.4 3.3 0.2 0.6 -1.4 -1.4 -1.0 -1.0 -1.7 -1.8 0.4
Diverticular disease/diverticulitis (self-reported) 1.3 1.6 3.6 -1.0 -1.6 -1.9 -0.2 -0.5 1.3 0.2 -1.3 -1.9
Medication: Atenolol 0.8 1.0 2.8 -1.4 -1.6 -0.3 1.2 0.1 0.1 0.3 -0.1 -1.7
Medication: Levothyroxine sodium 0.4 0.6 3.0 -0.6 -1.7 -0.2 0.6 0.4 0.8 0.1 -1.0 -0.0
Sitting height 0.4 2.7 7.8 -0.7 0.7 -1.4 -1.1 -1.9 2.8 -1.3 -2.4 -1.0
Chronic bronchitis/emphysema (father) 1.0 1.2 1.9 -1.4 -1.3 -0.9 1.3 1.0 -0.1 1.2 0.9 -1.1
High blood pressure (mother) 0.3 0.4 2.0 0.0 -1.0 -0.2 0.1 0.7 0.1 1.4 0.1 -0.3
Body mass index (BMI) 0.3 1.3 4.5 -1.1 0.4 -1.1 -1.1 -1.8 0.1 -2.1 -0.2 -0.4
Impedance of leg (left) 0.7 3.2 9.3 2.6 -3.0 -1.0 0.7 1.3 0.9 2.3 -1.3 -1.3
Leg predicted mass (left) 0.3 1.6 3.8 -1.9 1.4 -0.8 -0.7 -1.4 1.1 -1.9 -0.2 -0.7
Trunk fat mass 0.3 1.5 3.8 -1.0 -0.3 -1.9 -0.3 -1.2 1.3 -1.6 -0.4 -1.7
Waist circumference 1.2 4.5 9.3 -2.1 -1.0 -2.7 -1.4 -2.6 1.2 -2.3 -1.8 -3.1
Number of incorrect matches in round 0.9 1.6 7.5 -0.8 0.3 0.5 -0.1 0.7 -2.7 -0.2 -1.0 2.0
Past tobacco smoking 1.4 2.5 6.3 -1.1 -0.1 1.0 0.7 -2.4 2.4 -2.5 1.1 -0.6
Alcohol usually taken with meals 0.5 0.8 2.8 0.5 -1.0 -0.9 0.4 0.7 0.5 0.7 -1.7 -0.7
Nervous feelings 0.3 0.5 2.0 -1.4 -0.3 -0.1 0.8 -0.7 1.1 0.4 -0.1 -0.4
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.3 4.0 -1.5 -0.4 -0.1 -2.0 -1.7 -0.0 -0.8 -1.3 0.3
Hearing difficulty/problems with background noise 0.7 1.0 3.3 -0.3 -0.7 0.7 1.1 1.6 0.1 1.1 1.8 -0.3
Hair/balding pattern: Pattern 2 1.1 1.4 4.6 0.7 -0.9 -0.7 -1.6 -2.1 0.4 -1.6 -1.0 0.1
Had menopause 0.8 1.0 3.5 1.9 0.9 -0.9 -0.7 0.3 -1.6 -0.1 0.0 -0.5
Had other major operations 1.4 1.7 5.5 2.4 -0.6 -0.9 -1.6 -0.5 -0.1 -0.6 1.6 -1.8
Forced vital capacity (FVC) 0.7 2.6 8.2 -1.0 0.4 1.0 2.9 2.1 0.3 2.1 -1.6 1.4
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.8 6.9 0.5 0.8 2.0 2.6 1.4 0.3 2.5 1.7 1.4
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 3.1 0.3 1.8 -1.0 -1.3 -0.9 -0.0 0.2 0.7 -0.8
Qualifications: None of the above 0.5 1.1 2.4 1.4 0.7 0.2 0.7 1.2 0.7 1.5 1.5 -0.5
Financial difficulties in last 2 years 1.1 1.5 3.2 -0.9 0.1 1.1 1.8 1.3 0.9 1.6 -1.2 1.3
Mouth/teeth dental problems 1.2 1.8 5.8 0.9 0.5 1.7 1.1 1.4 -1.4 1.2 0.0 2.4
Heart attack 0.3 0.4 1.5 -0.1 -0.6 -0.1 0.6 0.4 1.0 0.5 1.2 0.0
Allergy 0.2 0.5 2.1 0.2 -0.7 -0.6 -0.8 -0.2 0.3 -0.9 -0.1 -1.4
Pain all over the body in last month 0.7 0.8 1.6 0.6 0.1 0.5 -1.2 -1.2 -0.8 -0.8 -0.8 1.3
Diabetes (self-reported) 0.6 0.9 2.1 -1.3 -0.1 0.3 -0.6 -0.8 -1.0 -0.6 -1.4 1.3
Hayfever/allergic rhinitis (self-reported) 1.1 1.4 4.3 -1.1 -1.5 -0.5 -0.3 -2.1 0.7 -1.3 -0.6 -1.3
Medication: Ramipril 1.6 2.1 6.3 -1.0 -1.8 1.7 2.5 1.1 1.2 0.8 1.4 0.0
Medication: Simvastatin 0.6 0.9 2.4 0.8 -1.6 -0.2 0.9 1.2 0.4 1.4 -0.1 -1.0
Fluid intelligence score 0.3 0.7 1.8 0.6 0.6 0.4 0.6 0.6 -1.2 -0.1 -1.1 1.3
Illnesses of siblings 0.6 0.9 3.9 0.4 -1.2 -0.8 0.1 -0.0 2.0 0.1 0.5 -1.3
Neuroticism score 0.5 1.0 2.8 -1.7 -1.2 -0.1 0.0 -0.3 1.7 0.8 0.6 -0.8
Weight 0.4 1.8 4.3 -1.3 0.7 -1.4 -0.9 -1.8 1.0 -2.1 -1.2 -0.9
Impedance of arm (right) 0.6 2.6 6.9 1.8 0.2 0.1 1.8 2.6 0.3 2.4 1.7 -0.8
Arm fat percentage (right) 0.2 0.8 2.6 -0.7 0.7 -1.1 -0.6 -1.1 0.2 -1.6 0.7 -0.8
Trunk fat-free mass 0.4 2.2 4.2 -1.5 1.2 -1.1 -1.6 -1.9 1.0 -2.0 -1.7 -0.9
Hip circumference 0.4 1.7 7.1 -0.9 1.5 -0.2 -0.8 -1.9 0.0 -2.7 -1.0 0.6
Time employed in main current job 0.4 0.4 1.3 -0.5 -0.7 -0.2 1.0 -0.1 0.2 0.8 -1.1 -0.0
Alcohol intake versus 10 years previously 1.5 2.2 8.4 -2.9 -0.9 -1.5 -0.6 -0.9 1.7 -0.8 -0.9 -1.7
Father’s age at death 2.7 3.6 9.3 -1.0 -0.1 -1.8 -2.1 -2.1 -0.7 -3.0 -2.6 -1.6
Worrier / anxious feelings 1.2 2.3 6.1 -2.1 -0.5 -1.0 -1.6 -2.5 0.7 -2.2 0.2 -1.0
Frequency of tiredness / lethargy in last 2 weeks 0.6 0.9 2.7 -1.6 0.3 0.8 1.2 0.2 0.9 1.4 0.7 -0.3
Falls in the last year 0.7 0.9 2.4 -0.4 0.3 -0.7 -1.4 -0.4 -1.2 -0.6 -1.2 1.5
Hair/balding pattern: Pattern 3 0.7 1.1 3.6 -0.6 -0.9 0.6 1.9 1.2 1.1 1.3 -0.1 -0.0
Number of live births 1.4 2.0 6.6 0.1 1.3 1.2 2.6 1.9 0.9 1.7 1.2 0.1
Forced expiratory volume in 1-second (FEV1) 0.6 1.9 6.2 -0.7 -0.6 1.1 2.5 1.3 1.3 1.7 -1.7 0.4
Pulse rate 2.4 4.0 9.4 -0.1 -0.6 -1.4 -2.1 -2.9 1.7 -2.9 -3.1 -0.3
Happiness 1.5 1.8 10.7 -0.5 -1.7 -0.8 0.4 0.5 3.3 0.5 -0.3 -1.1
Noisy workplace 1.0 1.3 2.9 0.7 1.7 1.7 -0.2 -0.4 0.9 -0.3 1.7 1.0
Qualifications: A levels/AS levels or equivalent 0.4 0.9 3.1 -1.6 -0.9 -0.7 -0.1 -0.7 0.3 -0.5 -1.8 -0.0
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.2 5.6 0.5 -1.4 -0.8 -0.3 1.2 0.4 2.4 0.3 -0.7
Mouth/teeth dental problems: Dentures 1.6 2.6 6.0 -0.2 -0.4 -1.9 -1.8 -2.1 1.6 -1.8 -0.4 -2.5
Asthma 0.2 0.4 0.9 0.1 0.8 -0.7 -0.5 -0.9 -0.1 0.0 -0.9 0.3
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 4.0 -0.7 -2.0 -1.0 -0.9 -0.6 0.1 0.2 -0.3 0.2
Medication: Cholesterol lowering 0.5 0.8 3.5 -0.9 -1.9 -0.3 1.0 0.5 0.1 1.0 -0.9 0.1
Depression (self-reported) 0.4 0.5 2.6 -0.4 0.4 0.2 0.4 0.2 1.6 -0.0 -0.2 1.0
Medication: Lansoprazole 1.7 1.9 5.4 0.6 -2.3 -2.3 -1.2 0.2 0.2 -0.2 0.2 -2.2
Prospective memory result 0.8 1.0 6.8 0.3 0.1 -0.2 0.1 1.0 -2.6 0.7 0.8 0.2
Lung cancer (father) 0.9 1.1 4.1 1.7 0.1 0.5 -0.4 0.1 -2.0 0.9 1.0 0.8
Illnesses of mother 0.5 0.6 2.0 -0.2 1.4 0.8 0.2 -0.9 -0.3 -0.7 -0.4 1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.9 9.5 -0.8 -0.6 1.6 3.1 1.4 1.4 2.1 -1.4 1.6
Pulse wave Arterial Stiffness index 2.3 2.7 5.4 1.7 1.2 0.6 -2.3 -2.1 -1.2 -2.2 -0.0 1.9
Impedance of arm (left) 0.7 3.2 9.0 2.0 -0.1 0.0 2.1 3.0 0.4 2.7 2.0 -0.6
Arm fat mass (right) 0.3 1.4 4.0 -1.0 0.5 -1.5 -1.1 -1.5 0.7 -2.0 -0.2 -0.9
Trunk predicted mass 0.4 2.3 4.2 -1.5 1.2 -1.2 -1.7 -1.9 0.9 -2.1 -1.7 -0.9
Standing height 0.2 1.7 7.1 -0.7 0.6 -1.1 0.1 -0.2 2.0 -0.1 -2.7 -1.2
Length of working week for main job 0.9 1.0 4.2 0.7 -0.1 -1.0 -2.0 -1.1 -0.8 -1.2 0.4 -0.5
Exposure to tobacco smoke at home 0.4 0.4 1.6 -0.6 0.3 0.2 1.3 0.9 -0.3 0.9 0.1 -0.4
Breastfed as a baby 0.4 0.5 1.6 0.7 -1.2 -0.3 -0.3 0.3 0.6 0.8 -0.1 -1.3
Tense / ‘highly strung’ 0.3 0.4 1.9 -0.7 -1.0 0.0 -0.3 -1.4 0.3 -0.3 -0.1 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 3.2 0.2 0.6 -0.9 -1.0 -1.1 1.8 -0.7 -0.3 -0.7
Hair/balding pattern: Pattern 4 0.7 1.8 4.1 -0.1 1.7 1.8 2.0 1.3 -0.9 1.0 0.3 1.4
Birth weight of first child 0.3 0.6 1.3 0.7 -0.1 0.5 -0.9 -1.0 -0.4 -0.4 -0.8 1.1
Peak expiratory flow (PEF) 0.6 1.4 3.2 -1.3 -1.8 -0.0 0.5 -1.0 1.8 -0.7 -1.3 -1.2
Pulse wave reflection index 2.4 3.0 9.0 0.9 2.5 2.2 0.4 0.3 -1.6 -0.1 1.7 3.0
Ever highly irritable/argumentative for 2 days 0.7 0.9 2.0 0.4 1.4 1.2 -0.4 -0.0 -0.5 0.5 1.2 1.4
Loud music exposure frequency 1.1 1.2 4.2 2.1 -0.3 0.2 -1.2 1.1 -1.1 -0.1 1.4 0.8
Qualifications: O levels/GCSEs or equivalent 1.6 2.5 7.4 -2.3 -1.7 -1.5 -0.7 -1.2 0.8 -1.1 -2.7 -1.2
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 2.1 0.8 0.1 0.4 0.8 1.4 0.5 1.1 0.9 -0.1
Blood clot in the leg (DVT) 0.7 0.9 2.9 -1.7 -0.1 -1.4 -0.7 -0.5 0.3 -0.7 -1.3 0.3
Medication: Paracetamol 0.4 0.7 2.3 -0.3 0.8 0.5 -0.9 -1.5 -0.6 -0.9 -0.4 1.0
Headache pain in last month 0.6 1.0 5.8 -0.4 -0.8 -0.2 0.6 -0.2 2.4 0.1 -0.2 -1.2
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 2.5 0.7 1.6 -0.1 -0.9 -0.7 0.6 -0.5 -0.1 -0.0
Glaucoma (self-reported) 0.4 0.4 1.2 0.8 -0.4 0.1 0.9 1.1 0.3 1.0 0.1 -0.0
Gout (self-reported) 0.6 0.8 4.0 -2.0 0.0 -1.3 -0.3 -0.4 -0.8 -0.8 -0.4 -0.2
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 3.0 -0.7 -1.7 -0.5 0.7 -0.5 1.6 -0.3 -1.2 -0.1
Medication: Amlodipine 0.4 0.5 2.2 -0.8 0.8 -0.3 0.2 -0.6 -1.5 -0.5 0.7 -0.3
Medication: Ventolin 100micrograms inhaler 0.6 0.8 2.3 0.2 1.5 -0.2 -0.9 -0.9 -1.5 -0.2 -0.0 0.7
Birth weight 0.2 0.5 1.8 0.0 1.3 -1.0 -1.0 -0.7 0.3 -0.5 0.3 -0.3
Chronic bronchitis/emphysema (mother) 0.4 0.5 3.2 0.0 1.8 0.5 0.2 -0.1 -0.5 -0.3 0.2 0.8
High blood pressure (siblings) 0.7 1.0 4.3 0.2 0.2 -0.6 0.0 1.0 -1.2 1.2 -2.1 0.4
Forced vital capacity (FVC), Best measure 0.9 3.1 10.3 -1.0 -0.1 1.2 3.2 1.9 0.8 2.1 -1.7 2.0
Body fat percentage 0.3 1.3 4.2 -0.4 -0.7 -2.1 -0.5 -1.1 0.8 -1.4 -0.2 -1.6
Leg fat percentage (right) 0.3 1.0 3.0 -0.5 -0.5 -1.7 -0.6 -1.4 0.3 -1.1 -1.2 -1.0
Arm fat-free mass (right) 0.5 2.5 5.7 -1.4 0.7 -1.4 -1.7 -2.2 1.1 -2.4 -1.7 -1.1
Exposure to tobacco smoke outside home 0.4 0.5 1.1 -0.1 1.0 0.4 0.8 1.0 0.9 0.7 0.6 0.4
Comparative body size at age 10 1.2 3.4 5.7 1.2 2.4 1.8 0.6 2.2 -1.8 1.7 2.1 2.0
Number of full brothers 2.4 3.0 7.1 1.8 2.2 1.8 1.4 1.6 0.0 2.0 2.7 0.3
Worry too long after embarrassment 0.6 1.0 4.8 -0.4 -0.5 -0.1 -0.2 0.5 1.2 0.5 2.2 -1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 3.1 4.0 12.6 -0.2 -0.5 -0.9 -2.4 -3.5 1.0 -3.4 -2.0 -0.6
Wheeze or whistling in the chest in last year 0.6 1.0 2.2 -1.5 1.0 -0.9 -1.4 -1.1 -0.8 -1.0 -0.9 -0.3
Number of children fathered 0.7 0.8 2.3 -1.1 0.9 0.9 -0.3 -0.5 -1.0 0.2 -0.2 1.5
Reason for reducing amount of alcohol drunk: Health precaution 1.8 2.1 7.1 0.1 -1.1 -2.1 -2.7 -1.0 -0.7 -1.2 -1.2 -1.5
Age at first live birth 0.2 0.3 1.0 1.0 0.6 1.0 -0.4 -0.3 0.1 -0.0 0.2 0.1
Pulse wave peak to peak time 2.5 2.9 6.0 -1.6 -1.0 -0.5 2.4 2.4 1.1 2.4 -0.2 -1.8
Health satisfaction 2.3 3.0 11.2 -1.0 -2.2 -1.2 0.4 -0.2 3.3 0.0 -0.4 -2.9
Shortness of breath walking on level ground 0.9 1.1 2.6 -0.8 1.6 -1.5 -0.9 -0.4 1.5 -0.1 0.8 -0.6
Qualifications: College or University degree 1.3 4.0 12.9 0.9 0.2 -1.7 -3.6 -2.3 -1.2 -3.1 -1.1 -1.0
Eye problems/disorders: None of the above 0.5 0.5 1.5 -1.2 -0.5 0.1 1.1 0.1 1.2 -0.1 -0.4 -0.4
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.9 -0.8 0.6 -1.4 0.3 0.2 0.6 0.3 -0.7 -1.2
Emphysema/chronic bronchitis 0.7 0.8 2.6 -0.3 1.6 0.2 -1.4 -0.3 -1.1 -0.8 -0.6 0.5
Medication for pain relief, constipation, heartburn 0.1 0.2 0.7 0.6 0.8 0.4 -0.5 0.3 -0.4 -0.2 -0.6 -0.2
Neck or shoulder pain in last month 0.7 0.9 2.2 -1.0 -1.2 -0.9 -0.8 -1.5 0.8 -0.3 -0.7 -0.9
Medication: Blood pressure 0.5 1.0 2.3 -0.1 -1.5 0.8 1.4 1.1 -0.7 0.9 1.0 0.6
Angina (self-reported) 0.8 1.0 3.3 -0.9 -1.8 -1.0 -1.1 -0.9 0.3 -1.2 0.3 0.2
Migraine (self-reported) 0.9 1.1 2.7 0.3 -0.2 -0.4 -1.1 -1.1 1.6 -1.6 0.6 -1.1
Medication: Ibuprofen 0.9 1.0 2.9 -1.5 -1.7 -1.1 -0.8 -1.2 0.1 -0.6 -0.5 -0.4
Medication: Allopurinol 1.0 1.4 2.9 -1.7 -0.2 -1.3 -1.5 -1.4 -0.8 -1.6 0.3 -0.7
Medication: Omeprazole 0.9 1.0 3.4 -0.8 1.6 1.8 1.4 0.0 0.7 -0.2 0.6 0.1
Medication: Seretide 50 evohaler 0.8 0.9 3.7 0.9 -0.2 -0.6 -1.5 0.0 -1.9 -0.1 -0.6 0.8
Mean time to correctly identify matches 0.3 0.5 1.1 -0.2 -1.0 -1.1 -0.9 -0.6 -0.1 -1.0 0.2 -0.7
Heart disease (mother) 0.4 0.5 1.4 -0.7 -0.7 -1.0 -0.0 0.4 0.7 0.0 -0.9 -1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 2.9 -1.7 -0.9 -0.8 -1.1 -0.9 -1.2 -1.0 -1.0 -0.1
Whole body fat mass 0.3 1.4 3.7 -0.9 -0.3 -1.9 -0.5 -1.2 1.3 -1.5 -0.4 -1.6
Leg fat mass (right) 0.3 1.3 3.5 -0.9 -0.0 -1.9 -0.8 -1.4 0.6 -1.3 -1.0 -1.2
Arm predicted mass (right) 0.5 2.8 5.0 -1.6 0.0 -1.8 -1.7 -2.1 1.2 -2.2 -2.1 -1.1
Pulse rate, automated reading 5.0 16.2 26.4 -1.2 -3.6 -4.3 -4.2 -4.9 2.8 -4.3 -4.3 -5.1
Alcohol intake frequency. 0.4 1.0 3.1 0.2 0.7 -0.6 -1.1 -0.6 0.3 -0.8 1.6 -1.8
Comparative height size at age 10 0.6 3.2 8.4 -0.6 0.5 -2.9 -0.6 -1.2 2.0 -1.4 -1.9 -2.9
Number of full sisters 1.1 1.3 2.3 -1.3 -1.5 -1.5 -0.3 -1.1 1.2 0.3 -1.1 -1.2
Suffer from ‘nerves’ 0.4 0.6 2.3 -1.5 0.2 1.0 0.7 0.2 -0.0 0.7 -0.4 1.2
Overall health rating 0.8 1.8 5.2 0.1 -0.2 1.6 1.4 0.6 2.3 1.4 1.8 -0.9
Chest pain or discomfort 0.3 0.4 2.1 -0.6 1.5 -0.0 -0.4 -0.6 -0.4 0.2 0.4 0.1
Had major operations 1.1 1.3 6.4 -0.5 0.7 -0.6 -0.5 0.5 -2.5 0.7 -0.6 1.6
Age at last live birth 1.1 1.7 4.2 0.7 2.0 2.0 1.3 0.7 -0.4 0.9 0.0 1.8
Family relationship satisfaction 0.9 1.1 2.6 -0.3 -0.5 -0.8 0.6 1.5 1.6 1.6 -0.4 -0.8
Leg pain on walking 0.9 1.2 5.0 1.1 1.7 -0.2 -0.4 0.6 0.4 1.0 2.2 0.1
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.4 -0.2 1.0 0.4 1.1 -0.5 0.9 -0.6 0.1 1.2
Commuting to job workplace: Car/motor vehicle 0.6 0.7 2.0 0.6 -1.2 -0.9 -0.0 0.1 1.4 1.3 0.6 0.4
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 2.4 1.3 1.6 0.4 0.0 -0.1 -0.7 -0.8 1.1 -0.0
Medication: Aspirin 1.4 1.9 4.8 0.5 -2.1 -0.8 1.3 2.2 0.6 2.1 0.6 -0.3
Supplements: Vitamin C 0.7 0.8 3.4 0.8 -1.1 -0.6 -0.1 -0.1 0.3 -0.2 -1.8 -1.1
Knee pain experienced in last month 0.3 0.5 1.9 -1.1 0.4 1.4 0.4 -0.2 0.5 -0.3 -0.2 0.8
Hypertension (Self-reported) 0.5 1.4 4.9 0.2 -0.3 0.9 2.2 1.8 -0.1 1.7 0.9 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 2.5 -0.2 -0.1 0.2 -0.1 -0.8 1.6 -0.8 0.0 -1.3
Illnesses of father: Heart disease 0.8 1.2 2.9 -0.1 -0.8 0.6 1.4 0.9 1.7 1.4 -1.1 -0.6
Illnesses of siblings: Diabetes 1.2 1.5 4.7 -1.1 -0.5 -1.1 -1.2 -1.8 -0.8 -2.2 -1.0 -0.4
Smoking status: Previous 1.2 1.8 5.9 0.7 0.1 -1.1 -0.2 2.1 -1.9 2.4 -0.5 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 2.5 -0.6 1.1 -0.1 -0.6 -1.6 0.4 -0.8 -0.2 0.3
Whole body fat-free mass 0.3 2.0 4.6 -1.7 1.2 -1.0 -1.2 -1.8 1.1 -2.1 -1.1 -0.9
Leg fat-free mass (right) 0.3 1.6 5.1 -1.6 1.6 -0.4 -0.9 -1.6 0.8 -2.2 -0.2 -0.2
Arm fat percentage (left) 0.2 0.8 2.1 -0.5 0.6 -1.3 -0.5 -0.8 0.3 -1.4 0.8 -0.8
Average weekly red wine intake 0.9 1.4 2.3 0.9 0.4 1.5 1.4 1.4 -0.9 1.5 -0.3 1.4
Handedness (chirality/laterality): Left-handed 0.7 0.8 1.7 -0.2 -0.5 -1.3 -1.1 -0.7 0.8 -0.9 -1.0 -1.0
Mood swings 1.4 2.6 6.2 -0.7 -0.1 -1.6 -2.5 -2.2 0.5 -1.9 -0.2 -2.2
Loneliness, isolation 0.5 0.7 2.1 -0.4 -1.1 -0.6 -1.4 -1.0 0.7 -0.3 -1.0 -0.1
Long-standing illness, disability or infirmity 0.6 1.0 3.0 -1.7 -0.2 -0.4 -0.3 -1.7 0.4 -1.3 -0.9 0.2
Ever had bowel cancer screening 0.4 0.5 1.8 -0.3 -0.0 -0.6 -0.4 -0.6 -1.3 0.2 -0.7 -1.1
Diabetes diagnosed by doctor 0.5 0.8 2.5 -1.6 -0.8 0.3 -0.3 -1.1 -0.4 -0.4 -1.1 1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 2.0 1.4 -0.3 -0.1 -0.4 -0.1 -0.9 -0.1 0.4 0.7
Friendships satisfaction 1.0 1.2 2.9 0.5 -1.4 -0.6 0.6 1.7 1.1 1.7 -1.1 -0.4
Qualifications: nursing, teaching 0.7 1.1 2.2 -0.7 0.9 -1.3 -1.5 -1.4 -0.9 -1.4 -0.5 -0.3
Commuting to job workplace: Walk 0.4 0.5 2.3 0.4 0.5 0.8 0.1 -0.4 -0.5 -0.6 0.1 -1.5
Eye problems/disorders: Cataract 0.9 1.1 4.0 2.0 0.0 0.3 -1.4 0.6 -1.1 1.1 0.6 0.7
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 2.6 -0.1 0.4 -1.4 -1.6 -0.2 -1.2 -0.5 -0.7 -0.3
Medication for cholesterol 1.6 2.4 7.6 -0.1 -0.8 -1.3 -2.8 -2.1 -0.3 -2.5 -0.5 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 1.0 1.8 0.7 -0.9 1.3 1.1 1.2 1.0 0.4 1.4 0.2
Back pain experienced in last month 0.9 1.3 3.5 -0.7 -1.6 -1.4 -0.9 -1.3 1.9 -0.4 -0.4 -0.9
Mineral and other dietary supplements 0.2 0.3 0.5 -0.7 0.4 0.6 -0.0 -0.0 0.7 0.3 0.7 0.5
Breast cancer (self-reported) 0.4 0.5 2.0 -0.5 -0.8 -0.7 -0.2 -0.2 0.3 0.2 0.8 -1.4
Asthma (self-reported) 0.3 0.6 1.5 -0.1 0.9 -1.1 -0.9 -1.2 -0.2 -0.4 -0.9 -0.0
Osteoporosis (self-reported) 1.5 1.8 6.7 -0.2 -1.0 -2.6 -2.0 -0.0 -1.9 -0.2 -0.4 -1.1
Osteoarthritis (self-reported) 0.7 0.9 2.8 -0.0 1.7 0.6 0.2 -0.8 -0.7 -1.0 1.6 0.3
Medication: Aspirin 0.7 0.9 2.8 0.7 -1.7 -0.9 0.5 1.6 -0.2 1.0 0.2 0.1
Medication: Gliclazide 0.9 1.1 4.0 -0.5 0.8 0.7 1.9 0.5 2.0 0.1 0.4 0.4
Illnesses of father: None of the above (group 1) 2.5 3.1 8.2 0.4 2.9 0.1 -1.8 -1.4 -2.2 -1.7 0.2 2.6
Smoking status: Current 0.7 1.2 3.2 -0.3 1.0 0.3 -1.7 0.1 -1.8 -0.4 -1.5 1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 2.0 1.0 -1.3 -0.4 0.7 0.7 0.8 1.4 -1.4 0.2
Whole body water mass 0.4 2.1 5.1 -1.7 1.3 -0.9 -1.3 -1.8 1.1 -2.2 -1.1 -0.8
Leg predicted mass (right) 0.3 1.4 4.4 -1.4 1.7 -0.3 -0.9 -1.5 0.7 -2.1 -0.1 -0.1
Arm fat mass (left) 0.3 1.1 2.7 -0.8 0.5 -1.5 -0.8 -1.3 0.9 -1.6 0.1 -0.9
Number of self-reported non-cancer illnesses 0.5 0.9 3.0 -0.6 -0.4 -0.3 1.3 -1.0 1.0 -0.2 -0.9 -1.7
Average weekly champagne plus white wine intake 0.7 0.9 3.1 0.1 -1.1 0.6 0.2 0.8 -1.3 0.8 -0.6 1.7
Miserableness 0.3 0.5 1.7 -0.9 -0.8 0.3 -1.3 -0.8 0.5 -0.2 -0.2 -0.1
Guilty feelings 0.5 0.8 3.2 -0.4 -0.4 0.1 0.9 0.9 1.0 1.8 -0.7 0.7
Wears glasses or contact lenses 0.3 0.3 0.8 -0.1 0.4 0.1 -0.9 -0.7 -0.7 -0.8 -0.3 -0.3
Ever taken oral contraceptive pill 1.0 1.1 2.5 0.9 0.5 0.4 0.8 1.5 1.3 1.1 1.6 -0.6
Hearing aid user 1.1 1.3 4.3 0.9 -0.2 -1.1 -1.1 -0.9 0.1 -1.2 1.1 -2.1
Mother’s age at death 2.2 2.8 9.4 2.4 1.4 0.5 -1.0 1.4 -3.1 1.3 0.6 1.6
Financial situation satisfaction 1.8 2.2 6.5 0.1 0.7 2.5 1.4 1.4 -0.8 1.3 1.3 2.3
Tinnitus: Yes, now most or all of the time 1.1 1.2 4.0 0.5 -1.4 0.8 0.0 0.6 1.7 0.9 2.0 -0.2
Commuting to job workplace: Public transport 0.9 1.1 2.6 -0.5 1.4 1.6 1.5 0.8 -0.6 -0.3 -1.0 0.8
Eye problems/disorders: Glaucoma 0.3 0.3 1.1 -0.3 -0.9 -0.1 0.5 -0.4 0.5 -0.5 0.1 -1.0
Medication: Blood pressure 0.7 1.3 4.5 -0.1 -0.2 0.2 2.1 1.7 0.1 1.9 0.6 -0.6
Pain type(s) experienced in last month: Hip pain 0.2 0.3 1.2 0.1 1.0 0.5 -0.2 0.2 -0.5 0.2 1.1 -0.0
Supplements: Fish oil (including cod liver oil) 0.2 0.2 1.0 0.7 0.0 0.2 0.4 0.3 -1.0 0.5 -0.4 -0.1
High cholesterol (Self-reported) 1.0 1.8 6.5 0.0 -2.5 -0.5 1.5 1.7 1.1 1.5 -0.8 -0.7
Medication: Bendroflumethiazide 0.4 0.7 2.7 -0.5 -0.1 0.1 0.8 0.0 1.2 0.1 1.0 -1.6
Medication: Paracetamol 0.8 1.2 3.3 -0.4 1.1 0.3 -1.5 -1.8 -1.0 -1.6 -0.4 0.5
Medication: Lisinopril 0.5 0.6 2.0 1.3 -0.2 0.0 -0.3 1.0 -0.7 0.2 1.4 0.1
Medication: Atorvastatin 1.2 1.5 3.3 -0.9 -1.4 -0.2 1.5 1.8 0.7 1.7 -0.4 1.2
Illnesses of father: High blood pressure 0.5 0.6 2.4 1.6 -0.1 -0.5 -0.5 0.5 0.4 0.8 -0.5 -1.1
Alcohol drinker status: Never 1.9 2.3 5.5 -0.9 -0.8 -1.9 -1.1 -1.8 -0.0 -2.3 -1.0 -2.0
Ever smoked 1.7 3.0 9.9 1.4 0.5 -0.6 -1.2 2.4 -3.1 2.2 -1.0 1.3
Basal metabolic rate 0.4 2.0 4.9 -1.6 1.1 -1.0 -1.2 -1.9 1.2 -2.2 -1.1 -0.9
Leg fat percentage (left) 0.3 1.0 2.1 -0.0 -0.8 -1.5 -0.8 -1.4 0.2 -1.4 -1.1 -0.6
Arm fat-free mass (left) 0.6 2.8 5.2 -1.6 0.6 -1.4 -1.6 -2.3 1.3 -2.3 -2.2 -1.0
Number of operations (self-reported) 0.7 1.1 4.2 0.8 0.4 -0.4 -1.3 -0.5 -2.0 -0.9 -1.4 0.1
Average weekly beer plus cider intake 0.2 0.3 0.8 -0.4 0.5 0.3 -0.3 -0.9 0.3 -0.8 -0.5 0.1
Irritability 0.2 0.4 1.3 -1.2 -0.4 -1.0 -0.7 -0.2 -0.6 0.0 -0.2 -0.3
Risk taking 0.5 0.7 2.3 -1.2 -0.4 -0.2 -0.7 -1.5 -0.4 -0.8 -0.9 -0.0
Ever had prostate specific antigen (PSA) test 0.8 0.9 2.9 0.4 -1.0 0.7 -0.1 0.2 -1.7 0.1 -1.0 1.5
Fractured/broken bones in last 5 years 0.7 0.8 3.3 0.6 -0.1 -0.7 -1.8 -1.2 0.1 -1.0 -0.7 -0.6
Age started oral contraceptive pill 0.3 0.4 1.5 0.9 -0.3 -0.4 0.7 1.2 0.3 0.5 0.3 -0.2
Diastolic blood pressure, automated reading 0.8 2.4 5.2 -0.8 -1.7 -0.5 -0.3 -2.1 1.4 -1.6 -2.3 -2.0
Ever depressed for a whole week 0.4 0.5 1.4 0.0 1.0 0.1 0.0 -0.5 1.2 0.6 0.5 -1.1
Unable to work because of sickness or disability 0.2 0.2 0.7 -0.5 -0.3 0.5 -0.1 -0.7 0.8 -0.2 0.1 0.7
Commuting to job workplace: Cycle 0.3 0.4 2.1 -0.5 0.2 1.5 0.5 0.3 -0.6 0.0 0.0 0.9
Myopia 1.0 1.4 4.4 -1.2 -1.4 -1.2 0.4 -1.0 2.1 -0.4 -0.8 -1.2
Vascular/heart problems diagnosed by doctor 0.3 0.9 2.2 -0.8 0.6 -0.3 -1.3 -1.5 0.2 -1.2 -1.3 0.4
Cholesterol lowering medication 1.8 2.6 5.6 0.0 -1.9 0.1 2.3 2.4 1.7 2.3 0.4 -0.6
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 2.7 -1.1 1.1 0.8 1.0 -0.8 1.6 -0.6 0.5 -1.1
Pain experienced in last month 1.1 1.9 7.5 1.0 1.8 0.3 -1.0 1.1 -2.7 -0.3 0.2 1.6
Supplements: Calcium 0.5 0.6 3.0 -0.1 0.3 -1.7 0.1 -0.1 0.2 0.2 -0.5 -1.4
Basal cell carcinoma (self-reported) 2.0 2.4 7.0 1.0 1.4 -0.3 -2.3 -1.1 -1.9 -2.6 0.9 -0.3
Heart attack/myocardial infarction (self-reported) 0.5 0.6 1.8 -0.0 -1.1 -0.3 0.6 0.3 1.4 0.5 1.4 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.7 1.0 2.4 -1.5 -0.3 -1.5 -1.0 -0.6 0.1 -0.8 -1.3 0.1
Heart disease (siblings) 0.5 0.6 2.7 -0.0 0.5 0.7 -0.2 0.5 -1.4 0.5 0.0 1.6
Alcohol drinker status: Previous 2.1 2.4 8.0 2.8 1.5 1.4 -0.2 1.6 0.6 0.3 2.3 1.0
Pack years of smoking 0.3 0.5 2.4 0.6 0.7 0.2 -0.8 0.2 0.2 -0.4 1.6 -0.5
Impedance of whole body 0.5 2.4 6.2 2.1 -1.6 -0.5 1.6 2.1 0.8 2.5 0.3 -1.1
Leg fat mass (left) 0.3 1.3 2.9 -0.7 -0.2 -1.7 -0.9 -1.5 0.6 -1.5 -1.0 -1.0
Arm predicted mass (left) 0.7 3.5 7.6 -1.7 0.5 -1.6 -1.9 -2.6 1.3 -2.8 -2.1 -1.2