TWAS hub - C19orf56

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0173	0.0117	0.0017	0.007	0.012	0.012	NA	0.011	0.013	0.0011	0.0014	NA	0.0018
2	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0450	0.0280	0.0020	0.026	0.035	0.025	NA	0.028	0.011	0.0041	0.0130	NA	0.0094
3	TCGA	Lung Squamous Cell Carcinoma	0.4242	0.1318	0.0025	0.002	-0.002	0.001	NA	0.004	0.160	0.5900	0.2600	NA	0.1100

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Number of incorrect matches in round	10.0	16.6	22.7	4.1	3.2	4.8
Loud music exposure frequency	8.3	9.1	10.3	-3.2	-3.2	-2.6
Mean Putamen Volume	6.9	7.8	13.0	3.2	3.6	0.0
Wears glasses or contact lenses	5.5	6.3	8.6	2.6	2.9	1.9
Lupus	4.7	7.2	11.5	-2.5	-2.0	-3.4
Mouth/teeth dental problems: Dentures	4.7	7.9	14.7	-2.9	-3.8	-0.8
Time employed in main current job	4.6	5.3	6.7	2.3	2.6	2.0
Heel T-Score	4.5	36.2	45.4	6.3	4.9	6.7
Trunk fat percentage	4.4	17.6	20.3	-4.4	-3.7	-4.5
Eye problems/disorders: Cataract	4.2	4.9	5.6	2.2	2.0	2.4
Trunk fat mass	4.0	17.3	19.7	-4.4	-3.6	-4.4
Family relationship satisfaction	3.9	4.8	5.6	2.4	2.2	2.0
Heel bone mineral density (BMD) T-score, automated (left)	3.7	8.5	14.3	2.6	2.1	3.8
Tinnitus: Yes, but not now, but have in the past	3.6	3.8	5.3	2.1	1.3	2.3
Body fat percentage	3.5	13.7	16.2	-3.8	-3.2	-4.0
High blood pressure (mother)	3.2	4.4	5.1	2.2	1.9	2.2
Hip circumference	3.2	13.7	17.3	-3.9	-3.0	-4.2
Whole body fat mass	3.2	13.4	15.5	-3.9	-3.1	-3.9
Knee pain experienced in last month	3.2	4.9	8.2	-1.9	-1.7	-2.9
Blood Red Count	2.9	27.9	43.2	5.5	3.1	6.6
Mouth/teeth dental problems	2.9	4.5	8.4	2.2	2.9	0.4
Leg fat percentage (right)	2.8	10.2	11.4	-3.3	-2.9	-3.4
Ever depressed for a whole week	2.8	3.5	8.8	1.2	0.3	3.0
Blood Platelet Count	2.7	31.0	42.1	-5.8	-4.2	-6.5
Eye problems/disorders: Diabetes related eye disease	2.6	2.9	4.1	-2.0	-2.0	-0.8
Chronic bronchitis/emphysema (father)	2.6	3.1	5.1	1.8	1.0	2.2
Arm fat mass (left)	2.6	10.7	12.9	-3.6	-2.8	-3.4
Waist circumference	2.5	9.0	10.6	-3.3	-2.7	-3.0
Weight	2.5	12.2	14.2	-3.8	-3.0	-3.6
Arm fat mass (right)	2.5	10.4	12.5	-3.5	-2.9	-3.2
Age at first live birth	2.4	4.3	6.2	1.0	2.5	-2.4
Reaction Time	2.3	4.4	6.6	-2.5	-2.6	-0.3
Arm fat percentage (right)	2.3	9.0	10.4	-3.2	-2.5	-3.2
Leg fat mass (right)	2.3	8.9	10.2	-3.2	-2.6	-3.1
Alcohol intake frequency.	2.2	5.1	10.1	-2.3	-3.2	-0.1
Arm fat percentage (left)	2.2	8.9	10.8	-3.3	-2.5	-3.1
Leg fat percentage (left)	2.2	7.8	8.9	-2.8	-2.6	-3.0
Heart attack/myocardial infarction (self-reported)	2.2	2.9	3.5	1.9	1.3	1.9
Commuting to job workplace: Cycle	2.1	2.5	3.1	-1.7	-1.3	-1.8
BMI	2.0	11.8	15.4	-3.6	-2.7	-3.9
Leg fat mass (left)	2.0	7.8	8.9	-3.0	-2.4	-2.9
Supplements: Zinc	1.9	2.1	2.2	1.4	1.4	1.5
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.3	7.1	1.9	1.5	2.7
Mean time to correctly identify matches	1.9	3.6	5.6	-2.4	-2.0	-1.0
Ever smoked	1.9	3.3	5.3	-2.3	-2.0	-0.8
Overall health rating	1.8	3.8	5.2	-2.0	-2.3	-1.4
Alcohol drinker status: Never	1.8	2.1	4.0	-1.5	-2.0	-0.3
Leg fat-free mass (left)	1.7	9.2	11.7	-3.4	-2.6	-3.0
Qualifications: CSEs or equivalent	1.7	2.2	5.5	-0.0	-1.1	2.3
Leg predicted mass (left)	1.7	8.8	11.2	-3.3	-2.5	-3.0
Heart attack	1.7	2.1	2.7	1.6	1.1	1.6
Worrier / anxious feelings	1.7	3.2	7.7	1.2	0.5	2.8
Length of working week for main job	1.7	1.8	5.0	0.1	-0.7	2.2
Medication: Seretide 50 evohaler	1.7	2.0	2.3	-1.5	-1.4	-1.3
Age at last live birth	1.7	2.5	4.9	1.0	2.2	-1.3
Qualifications: nursing, teaching	1.6	2.6	4.4	1.4	2.1	-1.1
Hand grip strength (left)	1.5	4.0	5.2	2.1	1.6	2.3
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	3.1	-1.2	-0.7	-1.8
Pulse rate	1.5	2.6	6.6	1.1	0.2	2.6
Body mass index (BMI)	1.4	5.8	7.0	-2.6	-2.2	-2.3
Falls in the last year	1.4	1.9	2.4	-1.5	-1.1	-1.6
Illnesses of mother	1.4	1.7	1.9	-1.4	-1.4	-1.2
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	2.5	-1.6	-1.5	-1.5
High blood pressure (siblings)	1.3	1.9	3.0	-1.3	-1.0	-1.7
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.1	1.3	1.8	0.0
Leg fat-free mass (right)	1.3	6.8	8.8	-3.0	-2.3	-2.5
Medication: Aspirin	1.3	1.7	2.0	1.4	1.3	1.2
Average weekly champagne plus white wine intake	1.3	1.8	3.1	-1.8	-1.5	-0.1
Basal metabolic rate	1.3	7.0	8.6	-2.9	-2.2	-2.7
Unable to work because of sickness or disability	1.3	1.6	2.0	-1.2	-1.2	-1.4
Average weekly spirits intake	1.2	1.5	1.9	-1.3	-1.4	-0.9
Age when periods started (menarche)	1.2	2.9	4.3	-1.9	-0.9	-2.1
Eye problems/disorders: None of the above	1.2	1.4	2.1	-1.1	-1.0	-1.4
Medication: Omeprazole	1.2	1.4	1.8	-1.4	-1.3	-0.9
Leg predicted mass (right)	1.2	6.5	8.5	-2.9	-2.2	-2.4
Financial situation satisfaction	1.2	1.5	4.4	0.0	-0.3	2.1
Verbal and Numeric Reasoning (VNR)	1.1	2.7	4.1	0.7	1.9	-2.0
Hand grip strength (right)	1.1	2.9	3.8	1.8	1.2	1.9
Past tobacco smoking	1.1	2.1	3.9	2.0	1.5	0.2
Glaucoma (self-reported)	1.1	1.2	3.0	-0.3	0.8	-1.7
Birth weight	1.1	2.4	3.4	-1.3	-1.9	-1.5
Leg pain on walking	1.1	1.3	1.8	-1.3	-1.1	-1.0
Supplements: Calcium	1.1	1.2	3.0	-0.5	0.6	-1.7
Intelligence (Savage-Jansen 2018)	1.0	3.0	6.6	1.2	2.6	-1.0
Alcohol usually taken with meals	1.0	1.6	3.9	-1.0	-0.1	-2.0
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	3.6	0.5	-0.1	1.9
Medication: Ramipril	1.0	1.3	2.5	-0.9	-0.7	-1.6
Pulse wave reflection index	1.0	1.2	1.8	-1.3	-1.0	-0.9
Loneliness, isolation	1.0	1.3	1.9	-1.3	-1.4	-0.7
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.0	-1.4	-1.2	-0.5
Depressed Affect (Nagel 2018)	0.9	1.9	3.4	-1.5	-1.8	-0.2
Depression (Nagel 2018)	0.9	1.3	2.1	-1.2	-1.4	-0.5
Crohns Disease (2012)	0.9	1.5	2.5	1.4	0.2	1.6
Ever used hormone-replacement therapy (HRT)	0.9	1.2	1.9	1.2	0.5	1.4
Sitting height	0.9	6.1	7.2	-2.6	-2.0	-2.7
Qualifications: College or University degree	0.9	3.0	4.8	0.6	1.9	-2.2
Whole body fat-free mass	0.9	5.0	6.2	-2.5	-1.9	-2.3
Whole body water mass	0.9	5.2	6.5	-2.5	-1.9	-2.3
Height	0.8	15.5	25.6	-3.9	-2.5	-5.1
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.9	0.4	-0.8	1.7
Had other major operations	0.8	1.0	2.0	-1.0	-1.4	-0.1
Qualifications: A levels/AS levels or equivalent	0.8	1.9	3.6	1.3	1.9	-0.6
Standing height	0.8	7.8	10.0	-2.9	-2.1	-3.2
Peak expiratory flow (PEF)	0.8	1.9	2.9	-1.5	-1.7	-0.9
Medication: Allopurinol	0.8	1.0	1.4	-1.2	-1.2	-0.6
Arm predicted mass (right)	0.8	3.9	4.8	-2.2	-1.5	-2.1
Handedness (chirality/laterality): Left-handed	0.8	1.0	1.2	1.0	0.9	1.1
Back pain experienced in last month	0.8	1.2	1.3	-0.9	-1.1	-1.1
Guilty feelings	0.8	1.2	2.1	1.0	0.6	1.5
Illnesses of father: High blood pressure	0.8	1.0	2.3	0.6	0.6	1.5
Arm fat-free mass (left)	0.8	4.3	5.1	-2.2	-1.9	-2.1
Arm predicted mass (left)	0.8	4.0	4.6	-2.1	-1.8	-2.1
Neuroticism (2016)	0.7	1.0	1.7	1.3	1.1	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.4	-1.0	-1.2	-0.5
Medication: Levothyroxine sodium	0.7	1.2	1.8	1.2	1.3	0.5
Fluid intelligence score	0.7	1.5	2.1	0.7	1.4	-1.4
Alcohol intake versus 10 years previously	0.7	1.1	2.2	-1.5	-0.5	-0.9
Depression (self-reported)	0.7	0.9	1.6	-1.0	-1.2	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	3.0	-0.1	-0.3	1.7
Qualifications: O levels/GCSEs or equivalent	0.7	1.0	3.0	-0.3	0.2	-1.7
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	1.8	-1.0	-1.3	0.4
Medication: Amlodipine	0.7	0.9	1.4	-1.0	-0.7	-1.2
Arm fat-free mass (right)	0.7	3.7	4.5	-2.1	-1.5	-2.0
Neck or shoulder pain in last month	0.7	1.0	2.4	0.8	-0.1	1.6
Medication: Blood pressure	0.7	1.2	1.9	1.3	1.4	0.3
Number of full sisters	0.7	0.9	1.7	-0.9	-1.3	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.1	-1.0	-1.1	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	1.6	-1.3	-0.9	-0.9
Osteoporosis (self-reported)	0.7	0.9	1.2	-1.1	-1.0	-0.6
Illnesses of father: None of the above (group 1)	0.7	0.9	1.9	-0.7	-0.6	-1.4
Smoking status: Current	0.7	1.2	2.6	-0.6	-1.6	0.7
Hearing aid user	0.7	0.8	1.4	1.0	-0.1	1.2
Heart disease (siblings)	0.7	0.9	2.0	0.8	0.4	1.4
Breast Cancer	0.6	1.5	3.0	1.2	1.7	-0.3
Primary Biliary Cirrhosis	0.6	0.9	1.9	-0.8	-0.2	-1.4
Smoking Status	0.6	1.5	2.6	-1.1	-1.6	0.9
Respiratory disease	0.6	1.2	3.1	0.5	-0.6	1.8
Chronotype (morning person)	0.6	1.5	3.3	-1.0	-0.1	-1.8
Ever had hysterectomy (womb removed)	0.6	0.7	0.9	-0.9	-0.6	-0.9
Pack years adult smoking proportion	0.6	0.9	1.4	-0.1	-1.2	1.1
Townsend deprivation index at recruitment	0.6	0.8	1.2	-0.7	-0.9	1.1
Current tobacco smoking	0.6	1.1	2.2	-0.3	-1.5	0.9
Happiness	0.6	0.8	1.1	-1.1	-1.1	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.7	0.8	1.3	0.2
Breastfed as a baby	0.6	0.7	1.6	0.3	1.3	0.7
Gout (self-reported)	0.6	0.8	1.3	-1.0	-1.2	-0.2
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.0	-0.9	-1.0	-0.5
Heart disease (mother)	0.6	0.7	1.0	0.7	0.7	1.0
Age started oral contraceptive pill	0.6	0.7	0.8	0.8	0.8	-0.9
Age at First Birth	0.5	0.8	2.4	0.0	1.5	0.0
Triglycerides	0.5	0.9	2.6	0.0	1.6	0.0
Neuroticism	0.5	1.2	3.2	0.1	-0.6	1.8
Systolic blood pressure, automated reading	0.5	1.6	2.7	-1.2	-0.8	-1.7
Medication for hormone replacement therapy	0.5	0.5	0.8	0.9	0.8	0.4
Stomach or abdominal pain in last month	0.5	0.6	1.0	-0.9	-1.0	0.0
Had menopause	0.5	0.6	1.2	-0.6	-0.4	-1.1
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.3	-0.6	-1.1	-0.7
Neuroticism score	0.5	1.1	2.9	0.3	-0.5	1.7
Trunk fat-free mass	0.5	3.0	3.6	-1.9	-1.3	-1.9
Noisy workplace	0.5	0.6	1.2	-0.0	-0.9	1.1
Blood clot in the leg (DVT)	0.5	0.7	1.1	0.8	1.0	0.5
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.2	0.8	0.3	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	0.9	0.9	0.6	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	0.9	-0.6	-1.0	0.8
Medication: Aspirin	0.5	0.6	0.8	0.9	0.7	0.7
Supplements: Vitamin C	0.5	0.5	1.5	-0.3	-0.1	-1.2
Smoking status: Previous	0.5	0.7	1.5	-1.2	-0.8	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.9	-0.9	-0.7	-1.4
Breast cancer (self-reported)	0.5	0.6	1.0	1.0	0.8	0.5
Asthma (self-reported)	0.5	1.0	2.4	0.7	-0.4	1.5
Osteoarthritis (self-reported)	0.5	0.7	1.5	-0.7	-0.4	-1.2
Medication: Gliclazide	0.5	0.6	0.7	-0.8	-0.8	-0.6
Commuting to job workplace: Public transport	0.5	0.5	1.1	0.5	1.0	0.5
Medication: Blood pressure	0.5	1.0	1.3	-1.1	-1.1	-0.6
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.9	-0.0	0.1	-1.4
Number of operations (self-reported)	0.5	0.7	0.9	-1.0	-0.9	-0.6
Pack years of smoking	0.5	0.7	1.1	-0.0	-1.0	1.0
Neuroticism (Nagel 2018)	0.4	1.0	1.6	-0.7	-1.3	0.9
Alzheimer’s Disease (in mother)	0.4	0.4	0.8	0.6	0.9	-0.3
Alzheimer’s Disease (in father)	0.4	0.5	1.1	0.4	0.3	1.1
Prostate Cancer	0.4	0.6	0.9	0.9	0.6	-0.7
HbA1C	0.4	0.4	1.3	0.0	1.1	0.0
Rheumatoid Arthritis	0.4	0.5	1.5	-0.1	0.1	-1.2
Waist Hip Ratio (WHR)	0.4	1.6	4.2	0.6	-0.5	2.0
Relative age of first facial hair	0.4	0.8	1.5	-0.7	-0.7	-1.2
Maternal smoking around birth	0.4	0.6	0.8	-0.9	-0.4	-0.9
Fed-up feelings	0.4	0.7	1.3	-0.4	-1.1	0.9
Impedance of leg (left)	0.4	1.9	3.1	1.8	1.0	1.2
Nervous feelings	0.4	0.7	1.3	-0.7	-1.1	-0.6
Qualifications: None of the above	0.4	0.8	1.6	-0.7	-1.3	0.6
Pain all over the body in last month	0.4	0.4	1.0	0.4	0.4	1.0
Illnesses of siblings	0.4	0.5	1.1	0.6	0.3	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.3	-0.1	-0.9	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.6	0.8	0.5	0.7
Trunk predicted mass	0.4	2.5	3.1	-1.8	-1.2	-1.8
Exposure to tobacco smoke at home	0.4	0.5	1.0	0.6	1.0	0.3
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.1	1.0	1.0	0.6
Number of full brothers	0.4	0.5	0.5	-0.7	-0.7	-0.6
Worry too long after embarrassment	0.4	0.6	1.7	0.5	-0.0	1.3
Health satisfaction	0.4	0.5	0.8	0.0	-0.8	0.9
Shortness of breath walking on level ground	0.4	0.5	1.3	-0.4	-0.2	-1.2
Migraine (self-reported)	0.4	0.5	1.3	0.5	1.1	0.0
Pulse rate, automated reading	0.4	1.3	2.4	1.0	0.5	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.2	0.4	0.1	1.1
Average weekly red wine intake	0.4	0.6	1.2	-0.7	-1.1	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.9	-0.4	-1.0	0.7
Worry (Nagel 2018)	0.3	0.7	1.5	-0.0	-0.7	1.2
Alzheimer’s Disease (including proxy)	0.3	0.4	0.6	0.6	0.5	0.8
Sensitivity / hurt feelings	0.3	0.5	1.3	-0.0	-0.5	1.2
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	0.6	-0.6	-0.1	-0.8
Diabetes (father)	0.3	0.3	0.8	-0.0	-0.5	0.9
Severe depression (siblings)	0.3	0.3	0.5	0.6	0.4	0.7
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.9	0.3	-0.3	0.9
Asthma	0.3	0.7	1.6	0.5	-0.4	1.3
Medication: Cholesterol lowering	0.3	0.5	0.6	0.8	0.7	0.6
Medication: Lansoprazole	0.3	0.3	0.5	-0.3	-0.6	0.7
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.1	0.0	-0.2	1.0
Forced vital capacity (FVC), Best measure	0.3	1.0	1.3	-0.9	-0.9	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.8	-0.5	0.1	-0.9
Friendships satisfaction	0.3	0.4	0.8	0.4	0.9	-0.2
Mother’s age at death	0.3	0.4	0.7	0.8	0.2	0.7
High cholesterol (Self-reported)	0.3	0.5	0.9	-0.6	-1.0	-0.5
Medication: Atorvastatin	0.3	0.3	0.5	-0.7	-0.7	-0.1
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.4	-0.5	-0.6	0.6
Alcohol drinker status: Previous	0.3	0.3	0.9	0.1	0.1	1.0
Bipolar Disorder or Schizophrenia	0.2	0.5	1.4	-0.1	0.2	-1.2
Fasting Glucose	0.2	0.3	0.8	0.0	-0.9	0.0
Cardiovascular Disease	0.2	0.7	1.1	-0.7	-0.7	-1.1
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.6	-0.7	-0.8	0.0
Tanning	0.2	2.8	4.6	1.6	1.1	2.1
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.5	0.3	-0.3	0.7
Diabetes (mother)	0.2	0.3	0.8	0.3	-0.1	0.9
Relative age voice broke	0.2	0.4	0.9	-0.4	-0.9	0.3
Serious illness, injury or assault to yourself	0.2	0.3	0.4	-0.6	-0.5	-0.4
Multivitamins +/- minerals	0.2	0.3	0.3	-0.5	-0.5	-0.6
Medication: Atenolol	0.2	0.3	0.5	-0.4	-0.2	-0.7
Hair/balding pattern: Pattern 2	0.2	0.3	0.4	0.2	0.6	0.6
Financial difficulties in last 2 years	0.2	0.3	0.9	-0.1	-0.2	1.0
Impedance of arm (right)	0.2	0.7	1.1	-0.8	-0.7	-1.0
Father’s age at death	0.2	0.2	0.7	0.1	0.2	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	0.9	-0.8	-0.9	-0.9
Impedance of arm (left)	0.2	0.9	1.2	-0.9	-0.8	-1.1
Headache pain in last month	0.2	0.3	0.9	-0.2	0.1	-0.9
Comparative body size at age 10	0.2	0.6	1.3	0.7	1.1	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.5	-0.7	-0.6	-0.1
Wheeze or whistling in the chest in last year	0.2	0.3	0.9	0.3	-0.2	0.9
Emphysema/chronic bronchitis	0.2	0.2	0.3	-0.4	-0.2	-0.5
Medication for pain relief, constipation, heartburn	0.2	0.3	0.3	-0.6	-0.6	-0.4
Comparative height size at age 10	0.2	0.9	2.4	-0.6	0.1	-1.5
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.5	0.7	0.1	0.4
Illnesses of siblings: Diabetes	0.2	0.2	0.6	0.8	0.4	0.0
Mood swings	0.2	0.3	0.8	0.5	-0.2	0.9
Ever had bowel cancer screening	0.2	0.2	0.4	-0.6	-0.5	-0.1
Diabetes diagnosed by doctor	0.2	0.4	0.4	-0.6	-0.6	-0.6
Commuting to job workplace: Walk	0.2	0.2	0.5	0.1	-0.2	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.5	0.1	0.2	-1.2
Number of self-reported non-cancer illnesses	0.2	0.3	0.6	-0.0	-0.5	0.8
Eye problems/disorders: Glaucoma	0.2	0.3	0.7	-0.3	0.2	-0.8
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.4	-0.6	-0.7	0.0
Average weekly beer plus cider intake	0.2	0.3	0.8	0.4	0.9	0.3
Risk taking	0.2	0.2	0.7	-0.3	-0.1	-0.8
Fractured/broken bones in last 5 years	0.2	0.3	0.4	-0.4	-0.5	-0.6
Vascular/heart problems diagnosed by doctor	0.2	0.5	0.7	-0.6	-0.9	0.5
Basal cell carcinoma (self-reported)	0.2	0.2	0.5	0.3	0.7	0.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.4	0.5	0.6	0.3
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	0.5	0.0	0.4
Crohns Disease (2017)	0.1	0.2	0.7	0.0	-0.8	-0.1
Ovarian Cancer	0.1	0.1	0.1	0.2	0.3	0.4
LDL Cholesterol	0.1	0.1	0.3	0.0	-0.6	0.0
Ulcerative Colitis	0.1	0.2	0.3	0.5	0.3	0.5
Blood Eosinophil Count	0.1	1.0	2.0	-0.5	-0.8	-1.4
Blood White Count	0.1	0.9	2.0	-0.7	-0.5	-1.4
Allergy or Eczema	0.1	0.3	0.6	-0.1	-0.8	-0.5
Hypothyroidism (self reported)	0.1	0.2	0.4	-0.2	0.2	-0.6
Lung FEV1/FVC ratio	0.1	0.7	1.1	1.0	0.6	0.8
Lung FVC	0.1	0.3	0.4	0.6	0.4	0.4
Number of treatments/medications taken	0.1	0.2	0.5	-0.2	0.5	-0.7
Angina	0.1	0.1	0.2	-0.0	-0.5	0.4
Vitamin and mineral supplements	0.1	0.1	0.2	0.2	0.2	0.5
Medication: Co-codamol	0.1	0.1	0.3	0.3	0.5	0.0
Impedance of leg (right)	0.1	0.6	1.2	1.1	0.7	0.3
Taking other prescription medications	0.1	0.1	0.3	0.3	0.5	-0.2
High blood pressure	0.1	0.4	0.5	0.3	0.7	-0.7
Supplements: Glucosamine	0.1	0.1	0.2	-0.2	0.5	-0.3
Allergy	0.1	0.2	0.3	-0.1	0.5	-0.5
Diabetes (self-reported)	0.1	0.2	0.4	-0.6	-0.3	-0.2
Lung cancer (father)	0.1	0.1	0.2	-0.1	-0.4	0.4
Hair/balding pattern: Pattern 4	0.1	0.3	0.7	0.5	0.8	0.1
Birth weight of first child	0.1	0.1	0.2	-0.3	-0.5	0.2
Exposure to tobacco smoke outside home	0.1	0.2	0.3	0.1	0.5	-0.5
Number of children fathered	0.1	0.1	0.3	0.4	0.5	0.1
Pulse wave peak to peak time	0.1	0.2	0.5	-0.1	0.1	-0.7
Angina (self-reported)	0.1	0.1	0.2	0.0	-0.4	0.5
Medication: Ibuprofen	0.1	0.2	0.3	-0.1	0.5	-0.5
Chest pain or discomfort	0.1	0.2	0.3	0.1	-0.6	0.4
Had major operations	0.1	0.1	0.3	-0.0	-0.6	0.1
Hypertension (Self-reported)	0.1	0.4	1.0	-0.0	0.4	-1.0
Long-standing illness, disability or infirmity	0.1	0.1	0.1	-0.4	-0.4	-0.3
Miserableness	0.1	0.2	0.4	-0.6	-0.4	-0.2
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	0.2	0.1	0.5
Medication: Bendroflumethiazide	0.1	0.1	0.2	-0.2	0.2	-0.4
Medication: Lisinopril	0.1	0.1	0.3	0.5	0.0	0.3
Irritability	0.1	0.1	0.2	-0.4	-0.2	-0.5
Diastolic blood pressure, automated reading	0.1	0.4	0.7	-0.7	-0.3	-0.8
Cholesterol lowering medication	0.1	0.2	0.4	-0.3	-0.6	-0.2
Bipolar Disorder (2018)	0.0	0.0	0.0	0.0	-0.1	0.0
Schizophrenia (2018)	0.0	0.1	0.3	0.0	0.6	0.0
Irritable Bowel Disease (IBD)	0.0	0.1	0.3	-0.1	-0.6	-0.1
Ulcerative Colitis (UC)	0.0	0.1	0.1	0.2	0.2	0.4
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.1	0.2	0.0	-0.5	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.1	0.0	-0.3	0.0
Schizophrenia (2014)	0.0	0.1	0.3	0.0	0.5	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Systolic Blood Pressure	0.0	0.1	0.2	-0.1	-0.5	-0.4
Hair Pigment	0.0	0.1	0.1	0.2	-0.3	0.3
Hearing difficulty/problems: Yes	0.0	0.0	0.0	-0.1	-0.1	-0.2
Medication: Metformin	0.0	0.0	0.1	-0.3	-0.2	0.2
Average weekly fortified wine intake	0.0	0.0	0.1	0.2	0.2	0.2
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.1	0.2	-0.4	-0.3
Hearing difficulty/problems with background noise	0.0	0.1	0.1	0.0	0.2	0.4
Forced vital capacity (FVC)	0.0	0.1	0.3	-0.2	-0.5	0.2
Medication: Simvastatin	0.0	0.0	0.1	0.1	-0.3	0.1
Hair/balding pattern: Pattern 3	0.0	0.1	0.1	0.3	0.2	-0.0
Number of live births	0.0	0.1	0.1	-0.3	-0.3	-0.1
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.2	-0.3	-0.5	0.1
Prospective memory result	0.0	0.0	0.0	0.1	-0.2	0.0
Pulse wave Arterial Stiffness index	0.0	0.1	0.1	-0.1	-0.2	0.3
Tense / ‘highly strung’	0.0	0.0	0.1	-0.0	-0.3	0.2
Medication: Paracetamol	0.0	0.0	0.0	0.1	0.0	-0.2
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	0.1	-0.3	-0.2
Suffer from ‘nerves’	0.0	0.0	0.1	-0.0	-0.0	0.3
Illnesses of father: Heart disease	0.0	0.0	0.1	0.2	0.3	-0.1
Medication for cholesterol	0.0	0.0	0.1	-0.3	-0.1	-0.3
Mineral and other dietary supplements	0.0	0.0	0.0	0.1	0.1	0.1
Ever taken oral contraceptive pill	0.0	0.1	0.1	0.2	0.3	-0.0
Medication: Paracetamol	0.0	0.0	0.1	0.1	0.0	-0.3
Myopia	0.0	0.1	0.1	0.2	0.1	0.3
Pain experienced in last month	0.0	0.0	0.1	0.2	0.2	0.0
Impedance of whole body	0.0	0.1	0.1	-0.1	-0.3	-0.2

Hub : Genes

C19orf56

Models

Trait associations