Hub : Genes

ZNF791

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Thyroid	0.0660	0.0290	6.8e-03	0.041	NA	0.023	NA	0.011	0.00039	NA	6.2e-03	NA	0.0470
2	TCGA	Breast Invasive Carcinoma	0.0445	0.0272	9.3e-05	0.012	0.020	0.019	NA	0.010	0.00120	0.00005	6.6e-05	NA	0.0028
3	TCGA	Brain Lower Grade Glioma	0.0410	0.0322	3.1e-03	0.004	0.015	0.004	NA	0.005	0.11000	0.00630	1.1e-01	NA	0.0860
4	TCGA	Thyroid Carcinoma	0.0350	0.0300	6.4e-03	0.013	0.015	0.019	NA	0.009	0.01900	0.01100	5.5e-03	NA	0.0420

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.0	0.0	0.0	0.0	0.0	-0.2	-0.1
Bipolar Disorder or Schizophrenia	0.2	0.4	0.7	-0.1	0.7	-0.8	0.5
Depressed Affect (Nagel 2018)	1.3	2.8	4.8	2.2	-1.9	-1.0	-1.3
Depression (Nagel 2018)	0.8	1.2	1.9	1.3	-1.4	-1.1	-0.4
Intelligence (Savage-Jansen 2018)	1.6	5.1	8.1	-2.5	1.9	1.4	2.8
Neuroticism (Nagel 2018)	0.5	1.2	2.2	1.1	-1.5	0.2	-1.1
Schizophrenia (2018)	0.3	0.5	0.8	-0.1	0.8	-0.9	0.8
Schizophrenia vs Biploar Disorder	0.1	0.1	0.4	-0.2	0.1	0.6	-0.3
Worry (Nagel 2018)	0.5	1.0	1.7	0.5	-1.3	0.6	-1.3
Alzheimer’s Disease (in mother)	0.8	0.9	1.4	-1.0	1.1	0.2	1.2
Alzheimer’s Disease (in father)	0.3	0.3	0.7	0.9	-0.2	0.5	0.3
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	0.2	0.6	0.2	0.9
Crohns Disease (2017)	0.4	0.9	1.7	1.1	0.5	-1.3	-0.6
Irritable Bowel Disease (IBD)	0.1	0.3	0.5	0.6	0.0	-0.7	-0.7
Ulcerative Colitis (UC)	0.1	0.1	0.2	-0.3	-0.2	0.5	-0.2
Major Depression (MDD)	0.6	0.7	1.1	1.1	-0.5	-0.8	-0.8
Reaction Time	3.6	6.9	13.4	1.9	-3.3	-0.2	-3.7
Verbal and Numeric Reasoning (VNR)	1.8	4.2	7.9	-1.6	2.5	-0.1	2.8
Breast Cancer	0.9	2.2	3.3	-1.8	1.8	1.2	0.9
Ovarian Cancer	0.4	0.5	1.4	-0.7	0.0	1.2	-0.1
Prostate Cancer	1.3	1.8	3.5	-0.8	1.9	-0.9	1.5
Age at First Birth	1.4	2.1	3.0	-1.7	1.2	1.5	1.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.2	0.5	0.7	-0.3	-0.4	-0.2
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.1	0.2	0.7	0.1	0.9	-0.4	0.2
Mean Putamen Volume	7.7	8.8	10.6	-3.0	2.4	3.3	3.1
Fasting Glucose	0.7	0.9	1.5	1.0	-1.2	-0.4	-0.9
HbA1C	1.0	1.1	2.7	-1.6	0.8	1.0	0.4
HDL Cholesterol	0.2	0.3	0.3	0.6	-0.5	-0.5	-0.5
LDL Cholesterol	0.4	0.6	1.3	1.0	0.0	-1.1	0.1
Lupus	2.5	3.8	10.4	1.8	-1.1	-3.2	-0.6
Neuroticism (2016)	0.7	1.0	2.5	-1.1	0.6	1.6	0.4
Primary Biliary Cirrhosis	0.1	0.1	0.3	-0.5	-0.3	-0.3	-0.0
Rheumatoid Arthritis	0.2	0.2	0.6	0.2	0.4	-0.8	0.2
Schizophrenia (2014)	0.4	0.9	1.5	-0.2	1.2	-1.0	1.0
Triglycerides	1.8	3.0	3.9	-2.0	1.9	1.2	1.8
Type 2 Diabetes (T2D) (2012)	0.9	1.0	4.1	-2.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.1	0.1	-0.2	-0.2	0.3	-0.3
Blood Eosinophil Count	0.2	1.7	5.2	0.8	1.0	-2.3	0.0
Blood Platelet Count	0.8	8.9	22.8	2.8	-1.9	-4.8	-1.1
Blood Red Count	0.9	9.1	20.1	-2.6	1.5	4.5	-2.6
Blood White Count	0.1	0.6	2.0	0.2	0.6	-1.4	0.3
Heel T-Score	2.1	16.4	30.6	-3.8	3.6	5.5	2.8
BMI	1.2	7.0	10.7	2.6	-2.2	-3.3	-2.4
Height	0.2	3.4	10.8	1.2	-1.2	-3.3	0.1
Waist Hip Ratio (WHR)	0.0	0.1	0.4	0.2	-0.1	0.6	-0.2
Systolic Blood Pressure	0.3	1.4	3.8	2.0	0.4	-1.3	0.2
Smoking Status	0.5	1.3	2.5	0.8	-1.4	-0.1	-1.6
Allergy or Eczema	0.2	0.5	1.6	0.4	0.4	-1.3	-0.4
Cardiovascular Disease	0.2	0.6	1.3	0.9	0.3	-1.2	0.2
Hypothyroidism (self reported)	0.2	0.4	0.9	-0.6	0.6	-0.3	1.0
Respiratory disease	0.5	1.2	3.3	0.5	-1.0	0.4	-1.8
Type 2 Diabetes (T2D) (2018)	0.6	1.2	2.8	0.5	-1.1	0.5	-1.7
Lung FEV1/FVC ratio	0.1	0.6	1.2	0.4	1.0	0.1	1.1
Lung FVC	0.2	1.0	1.6	-0.9	1.2	0.4	1.2
Neuroticism	0.4	0.9	1.3	0.3	-1.1	1.0	-1.1
Chronotype (morning person)	0.2	0.5	1.2	-0.5	-0.1	-0.6	1.1
Hair Pigment	0.0	0.0	0.0	-0.2	-0.1	0.2	-0.1
Tanning	0.2	2.0	2.1	-1.4	1.4	1.4	1.4
Hand grip strength (left)	1.2	3.2	4.5	-2.1	1.4	1.8	1.8
Number of treatments/medications taken	0.3	0.5	1.0	-1.0	0.6	0.5	0.7
Average weekly spirits intake	0.2	0.2	0.8	-0.2	-0.3	-0.9	-0.2
Sensitivity / hurt feelings	0.5	0.8	1.3	0.9	-1.1	0.4	-1.0
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.1	0.4	-0.3	-0.1	-0.3
Hearing difficulty/problems: Yes	0.0	0.0	0.1	-0.3	0.1	-0.0	0.1
Relative age of first facial hair	0.2	0.5	1.6	0.3	0.1	-1.2	-0.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	0.5	0.3	-0.7	-0.7	0.6
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.7	-0.2	0.8	0.4	0.2
Ever had hysterectomy (womb removed)	1.1	1.2	3.3	0.9	-1.8	-0.5	-0.7
Systolic blood pressure, automated reading	0.5	1.4	3.2	1.8	0.3	-1.6	-0.2
Eye problems/disorders: Diabetes related eye disease	3.7	4.0	6.3	2.5	-2.1	-1.5	-1.8
Angina	0.3	0.4	1.1	1.1	-0.0	-0.6	-0.2
Medication for hormone replacement therapy	1.8	2.0	4.3	-1.1	1.5	0.0	2.1
Vitamin and mineral supplements	0.1	0.1	0.4	-0.4	0.2	0.6	-0.0
Supplements: Zinc	1.9	2.1	3.5	-1.7	1.0	1.9	1.0
Medication: Co-codamol	0.7	0.8	2.0	0.3	0.9	-0.5	1.4
Medication: Metformin	0.2	0.3	0.6	0.6	-0.1	0.3	-0.8
Diabetes (father)	0.6	0.7	1.5	0.8	-0.8	-0.0	-1.2
Diabetes (mother)	0.4	0.5	1.3	0.8	-0.0	0.1	-1.1
Severe depression (siblings)	0.5	0.6	0.9	-1.0	0.6	0.5	0.8
Pack years adult smoking proportion	0.6	0.9	1.2	1.1	-0.6	-0.9	-1.0
Impedance of leg (right)	0.3	1.4	2.7	-1.0	1.3	-0.1	1.7
Leg fat-free mass (left)	1.0	5.1	6.3	2.1	-2.5	-2.4	-2.0
Trunk fat percentage	2.3	9.3	16.7	3.0	-2.2	-4.1	-2.6
Hand grip strength (right)	0.8	2.2	3.0	-1.4	1.7	1.0	1.7
Townsend deprivation index at recruitment	1.6	2.2	4.6	0.7	-1.7	1.1	-2.1
Current tobacco smoking	1.0	1.7	2.3	1.5	-0.8	-1.2	-1.5
Average weekly fortified wine intake	0.4	0.5	1.3	-0.2	0.7	0.1	1.1
Maternal smoking around birth	0.1	0.2	0.3	-0.4	-0.6	0.3	-0.4
Fed-up feelings	0.9	1.7	2.9	1.7	-1.3	-0.1	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.3	0.8	-1.2	-0.7	-0.6
Relative age voice broke	0.5	0.7	1.2	0.9	-1.1	-0.8	-0.6
Taking other prescription medications	0.6	1.0	1.4	-1.0	1.2	0.2	1.2
Age when periods started (menarche)	0.3	0.6	1.3	0.7	-0.6	-1.1	-0.5
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	2.4	1.3	-1.2	-1.5	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	1.8	4.0	12.5	-1.7	0.7	3.5	0.1
Tinnitus: Yes, but not now, but have in the past	2.2	2.4	4.6	-1.7	1.2	2.1	0.6
Qualifications: CSEs or equivalent	1.4	1.9	3.1	-0.2	-1.8	1.1	-1.8
Serious illness, injury or assault to yourself	0.5	0.6	0.8	0.8	-0.9	-0.6	-0.7
High blood pressure	0.5	1.4	3.1	0.5	1.4	-0.5	1.8
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	-0.3	0.4	-0.7	-0.2
Multivitamins +/- minerals	0.3	0.4	0.6	0.6	-0.8	-0.7	0.1
Stomach or abdominal pain in last month	2.6	3.2	6.9	0.8	-2.3	0.3	-2.6
Supplements: Glucosamine	0.4	0.6	1.5	-1.2	0.1	0.7	0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.4	0.6	-0.0	-0.1	-0.4
Medication: Atenolol	0.2	0.2	0.5	0.2	0.5	-0.5	0.7
Medication: Levothyroxine sodium	1.7	2.9	4.0	-2.0	1.8	1.0	1.9
Sitting height	0.3	2.1	3.2	0.7	-1.8	-1.5	-1.6
Chronic bronchitis/emphysema (father)	0.5	0.6	1.6	-0.7	0.6	1.3	0.0
High blood pressure (mother)	2.2	3.1	5.2	-1.8	1.5	2.3	1.2
Body mass index (BMI)	1.1	4.6	6.0	2.4	-1.7	-2.5	-2.0
Impedance of leg (left)	0.4	2.0	3.1	-1.4	1.8	0.4	1.8
Leg predicted mass (left)	0.9	4.8	5.9	2.1	-2.4	-2.3	-1.9
Trunk fat mass	2.1	8.9	15.4	2.9	-2.3	-3.9	-2.5
Waist circumference	1.4	5.1	8.4	2.5	-1.8	-2.9	-1.6
Number of incorrect matches in round	5.2	8.6	18.3	-3.0	2.3	4.3	1.4
Past tobacco smoking	1.2	2.2	4.9	-0.6	2.2	-0.5	1.8
Alcohol usually taken with meals	0.5	0.9	2.2	0.8	-0.4	-1.5	0.7
Nervous feelings	0.4	0.7	0.9	0.9	-0.8	-1.0	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.2	1.1	-0.3	0.0	-0.9
Hearing difficulty/problems with background noise	0.1	0.2	0.5	-0.1	-0.0	0.7	-0.7
Hair/balding pattern: Pattern 2	1.2	1.5	3.4	-1.8	0.1	1.6	0.0
Had menopause	0.2	0.3	0.7	0.3	0.6	-0.8	-0.1
Had other major operations	2.2	2.6	3.1	1.8	-1.8	-1.3	-1.6
Forced vital capacity (FVC)	0.0	0.1	0.2	-0.0	-0.5	0.1	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	6.1	-1.0	0.5	2.5	-0.1
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.3	0.6	-0.9	1.0	-1.1
Qualifications: None of the above	0.9	1.9	4.0	1.7	-0.7	-0.4	-2.0
Financial difficulties in last 2 years	0.4	0.6	0.8	0.0	-0.9	0.8	-0.9
Mouth/teeth dental problems	4.0	6.1	9.1	-2.6	2.4	1.6	3.0
Heart attack	1.1	1.4	2.5	-0.9	1.6	0.9	1.2
Allergy	0.1	0.2	0.4	0.5	0.1	-0.1	0.6
Pain all over the body in last month	0.3	0.3	0.6	-0.7	0.2	0.8	0.1
Diabetes (self-reported)	0.3	0.5	1.1	0.6	-0.6	0.1	-1.0
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.6	0.8	-0.3	-1.3	-1.1
Medication: Ramipril	1.7	2.1	4.0	2.0	-0.5	-2.0	-0.6
Medication: Simvastatin	0.1	0.2	0.2	0.3	0.5	-0.5	-0.2
Fluid intelligence score	1.0	2.1	4.7	-0.6	1.8	-0.3	2.2
Illnesses of siblings	0.3	0.4	1.0	-0.8	0.2	1.0	0.2
Neuroticism score	0.5	0.9	1.7	0.4	-1.0	1.0	-1.3
Weight	1.3	6.5	10.8	2.6	-2.2	-3.3	-2.0
Impedance of arm (right)	0.0	0.1	0.2	0.0	-0.4	-0.4	-0.3
Arm fat percentage (right)	1.2	4.6	6.8	2.0	-1.7	-2.6	-2.2
Trunk fat-free mass	0.2	1.3	2.9	1.1	-1.1	-1.7	-0.1
Hip circumference	1.7	7.4	14.2	2.8	-2.0	-3.8	-1.8
Time employed in main current job	4.8	5.5	8.6	-2.7	1.7	2.9	1.9
Alcohol intake versus 10 years previously	0.4	0.6	1.5	0.5	-1.2	0.2	-0.6
Father’s age at death	0.4	0.5	0.9	0.2	0.8	-0.5	1.0
Worrier / anxious feelings	0.6	1.1	3.7	-0.7	-0.4	1.9	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.1	1.4	-1.1	-0.5	-0.6
Falls in the last year	1.8	2.4	3.8	2.0	-1.3	-1.7	-1.2
Hair/balding pattern: Pattern 3	0.1	0.2	0.6	0.7	0.1	-0.5	-0.2
Number of live births	0.0	0.1	0.2	-0.0	0.1	0.1	0.4
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.4	0.3	-0.6	-0.2	-0.1
Pulse rate	0.3	0.5	1.5	0.4	0.4	1.2	-0.4
Happiness	1.5	1.8	4.4	1.2	-2.1	-0.1	-1.2
Noisy workplace	1.2	1.5	5.3	-0.2	-0.6	0.6	-2.3
Qualifications: A levels/AS levels or equivalent	1.8	4.0	8.0	-2.0	1.9	0.6	2.8
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	-0.1	0.4	0.1	0.3
Mouth/teeth dental problems: Dentures	6.7	11.4	18.4	4.3	-2.7	-2.9	-3.3
Asthma	0.2	0.5	1.3	-0.4	-0.5	0.4	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	2.4	-1.6	0.7	1.1	0.8
Medication: Cholesterol lowering	0.5	0.8	1.5	-0.3	1.2	0.4	1.2
Depression (self-reported)	2.0	2.4	4.9	0.6	-2.0	0.2	-2.2
Medication: Lansoprazole	1.6	1.8	2.9	1.7	-1.5	-0.1	-1.3
Prospective memory result	0.1	0.2	0.3	0.3	-0.6	-0.5	-0.2
Lung cancer (father)	0.2	0.3	0.6	0.5	-0.1	-0.5	-0.8
Illnesses of mother	1.4	1.7	2.5	1.2	-1.6	-1.2	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.3	1.0	-0.7	-1.1	-0.4
Pulse wave Arterial Stiffness index	0.0	0.0	0.1	0.1	0.2	-0.2	0.0
Impedance of arm (left)	0.0	0.1	0.2	0.0	-0.2	-0.4	-0.1
Arm fat mass (right)	1.6	6.5	8.4	2.6	-2.2	-2.9	-2.5
Trunk predicted mass	0.2	1.1	2.6	1.0	-1.0	-1.6	-0.0
Standing height	0.2	1.9	4.4	0.9	-1.5	-2.1	-0.4
Length of working week for main job	2.8	3.1	4.8	1.6	-2.2	0.5	-2.2
Exposure to tobacco smoke at home	1.1	1.2	2.5	-1.6	0.8	1.0	0.8
Breastfed as a baby	1.3	1.7	4.0	-1.3	-0.1	2.0	1.0
Tense / ‘highly strung’	0.2	0.3	0.6	0.7	-0.4	-0.0	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.3	-0.0	-1.0	1.1	-0.3
Hair/balding pattern: Pattern 4	0.1	0.2	0.5	-0.1	0.6	0.3	0.7
Birth weight of first child	0.1	0.2	0.6	0.3	0.1	-0.5	0.8
Peak expiratory flow (PEF)	0.9	2.2	3.7	1.3	-1.9	-1.3	-1.3
Pulse wave reflection index	0.6	0.7	1.3	0.7	-1.1	-1.0	-0.4
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.1	-0.7	-0.2	1.1	-0.3
Loud music exposure frequency	8.3	9.1	12.3	3.0	-2.9	-2.6	-3.5
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.3	-1.1	0.4	-0.7	1.1
Mouth/teeth dental problems: Bleeding gums	1.4	1.9	3.3	0.9	-1.8	-0.0	-1.8
Blood clot in the leg (DVT)	0.9	1.1	1.4	-1.2	0.8	1.1	1.1
Medication: Paracetamol	0.5	0.9	2.3	-1.5	0.4	0.6	-0.9
Headache pain in last month	0.2	0.3	0.9	-0.1	-0.3	-0.2	-1.0
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	4.0	0.7	-1.5	-1.1	-2.0
Glaucoma (self-reported)	1.3	1.5	2.3	-1.5	1.5	0.3	1.2
Gout (self-reported)	0.9	1.2	2.2	1.5	-1.0	-0.5	-1.2
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	3.1	-1.8	1.5	0.8	1.7
Medication: Amlodipine	1.0	1.4	3.0	1.7	-0.6	-1.4	0.5
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.5	0.2	0.7	-0.1	0.5
Birth weight	1.6	3.4	8.8	2.1	-0.7	-3.0	-0.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.2	1.1	0.0	-0.9	-0.9
High blood pressure (siblings)	0.8	1.1	2.4	1.2	-0.4	-1.6	-0.7
Forced vital capacity (FVC), Best measure	0.1	0.4	0.9	0.5	-0.6	-0.9	-0.3
Body fat percentage	1.9	7.5	14.0	2.7	-1.8	-3.7	-2.3
Leg fat percentage (right)	1.9	7.0	13.2	2.7	-1.7	-3.6	-2.2
Arm fat-free mass (right)	0.4	1.9	3.6	1.4	-1.2	-1.9	-0.6
Exposure to tobacco smoke outside home	0.0	0.1	0.2	0.1	-0.4	-0.2	-0.1
Comparative body size at age 10	0.2	0.5	1.2	-0.3	1.1	0.4	0.7
Number of full brothers	1.0	1.2	1.8	1.2	-0.6	-1.1	-1.4
Worry too long after embarrassment	0.2	0.3	0.8	-0.3	-0.5	0.9	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.7	0.8	-0.8	-0.7	0.1
Wheeze or whistling in the chest in last year	0.1	0.1	0.3	-0.1	-0.2	0.3	-0.5
Number of children fathered	0.6	0.7	1.0	-1.0	0.9	0.3	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.1	0.1	-0.2	-0.3	0.2	-0.2
Age at first live birth	4.5	8.1	13.0	-3.6	2.8	0.6	3.3
Pulse wave peak to peak time	0.0	0.0	0.1	-0.0	-0.3	0.0	0.0
Health satisfaction	0.4	0.6	1.4	1.2	-0.5	-0.4	-0.7
Shortness of breath walking on level ground	0.4	0.4	1.3	0.3	0.3	-1.1	0.5
Qualifications: College or University degree	1.4	4.5	9.0	-2.1	2.1	-0.4	3.0
Eye problems/disorders: None of the above	0.7	0.8	1.7	0.8	-0.7	-1.3	-0.4
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.8	-0.1	0.5	-0.9	-0.2
Emphysema/chronic bronchitis	0.2	0.2	0.3	0.6	-0.5	-0.5	-0.1
Medication for pain relief, constipation, heartburn	0.8	1.3	2.9	1.7	-1.0	-1.1	0.0
Neck or shoulder pain in last month	0.6	0.9	2.3	1.0	-0.3	0.2	-1.5
Medication: Blood pressure	1.2	2.2	6.2	-0.4	1.5	0.1	2.5
Angina (self-reported)	0.3	0.4	1.1	1.1	0.1	-0.5	-0.2
Migraine (self-reported)	0.7	0.9	1.7	-1.3	0.6	1.1	0.4
Medication: Ibuprofen	0.5	0.6	1.7	-1.3	0.3	0.6	0.4
Medication: Allopurinol	0.8	1.0	1.5	1.2	-1.1	-0.9	-0.8
Medication: Omeprazole	0.6	0.7	0.9	0.7	-0.9	-1.0	-0.8
Medication: Seretide 50 evohaler	1.6	1.8	2.5	1.1	-1.3	-1.3	-1.6
Mean time to correctly identify matches	1.7	3.3	6.4	1.0	-2.4	-0.4	-2.5
Heart disease (mother)	1.0	1.2	2.0	-1.4	0.5	1.4	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.5	-0.1	1.6	-0.1	1.4
Whole body fat mass	1.6	6.8	12.4	2.6	-1.9	-3.5	-2.1
Leg fat mass (right)	1.5	5.6	8.8	2.4	-1.9	-3.0	-2.1
Arm predicted mass (right)	0.4	2.0	3.9	1.4	-1.3	-2.0	-0.6
Pulse rate, automated reading	0.2	0.5	0.9	-0.6	1.0	0.9	0.1
Alcohol intake frequency.	4.2	9.8	12.7	3.6	-3.2	-2.0	-3.5
Comparative height size at age 10	0.2	1.0	2.5	-0.7	0.8	-0.6	1.6
Number of full sisters	0.8	1.0	1.2	1.1	-1.0	-1.0	-0.9
Suffer from ‘nerves’	0.4	0.6	1.0	-0.3	-0.9	0.8	-1.0
Overall health rating	1.8	3.8	5.7	2.1	-1.5	-2.4	-1.7
Chest pain or discomfort	0.2	0.3	0.6	0.8	-0.2	-0.7	-0.3
Had major operations	0.3	0.3	0.6	0.6	0.2	-0.7	-0.4
Age at last live birth	3.2	4.6	8.4	-2.5	1.6	0.9	2.9
Family relationship satisfaction	1.4	1.7	3.4	-0.7	1.5	1.9	0.8
Leg pain on walking	1.5	1.9	3.3	1.4	-1.8	-0.9	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.7	0.1	-1.6	0.4	-1.2
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.8	-0.3	0.9	-0.3	-0.1
Illness, injury, bereavement, stress in last 2 years	2.5	3.0	4.3	-2.1	1.9	1.3	1.6
Medication: Aspirin	1.2	1.6	2.3	-1.2	1.5	0.7	1.4
Supplements: Vitamin C	0.3	0.4	1.0	-0.0	0.7	-1.0	0.3
Knee pain experienced in last month	1.5	2.3	7.8	1.2	-0.3	-2.8	-0.0
Hypertension (Self-reported)	0.5	1.3	2.2	0.7	1.4	-0.8	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	0.6	-0.3	0.5	-0.4
Illnesses of father: Heart disease	0.6	0.8	2.3	-0.4	1.5	0.1	0.8
Illnesses of siblings: Diabetes	0.4	0.5	1.0	0.7	0.4	-1.0	0.6
Smoking status: Previous	0.7	1.0	2.2	0.0	-1.5	1.0	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.0	-0.3	-0.5	-1.0	-0.4
Whole body fat-free mass	0.4	2.5	4.0	1.5	-1.7	-2.0	-0.9
Leg fat-free mass (right)	0.7	3.7	4.8	1.8	-2.2	-2.0	-1.7
Arm fat percentage (left)	1.2	4.6	6.0	2.0	-1.8	-2.5	-2.2
Average weekly red wine intake	0.5	0.7	1.2	1.1	-0.9	-0.9	-0.1
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.2	-0.8	0.6	1.1	0.9
Mood swings	0.1	0.2	0.6	0.8	-0.3	-0.2	-0.1
Loneliness, isolation	1.9	2.6	3.6	1.9	-1.6	-1.2	-1.7
Long-standing illness, disability or infirmity	0.2	0.4	0.7	0.8	0.0	-0.8	0.3
Ever had bowel cancer screening	0.2	0.3	0.4	0.6	-0.6	-0.1	-0.6
Diabetes diagnosed by doctor	0.3	0.5	0.9	0.8	-0.3	-0.5	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	0.7	0.8	-0.8	-0.8	-0.1
Friendships satisfaction	0.1	0.2	0.3	-0.3	0.4	0.5	0.5
Qualifications: nursing, teaching	3.5	5.4	8.7	-3.0	2.5	0.6	2.5
Commuting to job workplace: Walk	0.6	0.6	1.1	0.3	-1.0	0.7	-0.9
Eye problems/disorders: Cataract	1.7	1.9	4.7	-1.4	1.0	2.2	0.5
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.8	0.9	-1.7	-0.5	-0.8
Medication for cholesterol	0.2	0.2	0.5	0.2	-0.7	0.0	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.7	0.8	-0.4	-0.5	-0.2
Back pain experienced in last month	0.8	1.1	1.5	1.2	-0.6	-1.2	-1.1
Mineral and other dietary supplements	0.0	0.0	0.1	0.3	-0.2	-0.1	-0.2
Breast cancer (self-reported)	0.5	0.6	1.2	-0.0	1.1	-0.2	1.0
Asthma (self-reported)	0.2	0.5	1.4	-0.3	-0.4	0.5	-1.2
Osteoporosis (self-reported)	1.3	1.6	3.8	2.0	-0.9	-1.2	-0.8
Osteoarthritis (self-reported)	0.3	0.4	0.6	0.5	0.4	-0.8	-0.7
Medication: Aspirin	2.6	3.4	4.3	-2.0	2.1	1.4	1.9
Medication: Gliclazide	0.7	0.8	1.6	1.3	-0.5	-0.7	-1.0
Illnesses of father: None of the above (group 1)	0.7	0.9	2.2	1.0	-0.5	-1.5	-0.0
Smoking status: Current	1.2	1.8	2.6	1.5	-1.0	-1.2	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.7	-0.3	0.4	-0.8	0.8
Whole body water mass	0.4	2.5	4.0	1.5	-1.7	-2.0	-0.9
Leg predicted mass (right)	0.7	3.6	4.6	1.8	-2.2	-1.9	-1.7
Arm fat mass (left)	1.5	6.3	8.6	2.5	-2.1	-2.9	-2.4
Number of self-reported non-cancer illnesses	0.1	0.3	0.8	-0.1	-0.1	0.5	-0.9
Average weekly champagne plus white wine intake	1.8	2.5	5.0	1.5	-2.2	-0.2	-1.7
Miserableness	0.3	0.5	1.3	0.4	-1.1	0.3	-0.5
Guilty feelings	0.5	0.8	1.2	-0.7	0.8	1.1	0.9
Wears glasses or contact lenses	6.8	7.8	8.9	-2.8	2.9	2.5	3.0
Ever taken oral contraceptive pill	0.1	0.1	0.3	-0.5	0.1	0.2	0.3
Hearing aid user	0.6	0.7	1.3	1.0	0.6	-1.1	0.3
Mother’s age at death	0.3	0.4	1.7	-0.2	1.3	0.0	-0.0
Financial situation satisfaction	1.4	1.7	2.5	1.1	-1.6	1.1	-1.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.4	-0.1	-0.2	0.4	-0.6
Commuting to job workplace: Public transport	0.6	0.7	2.1	-0.9	0.1	1.4	0.3
Eye problems/disorders: Glaucoma	0.4	0.5	0.8	-0.8	0.9	-0.0	0.8
Medication: Blood pressure	0.5	0.9	1.7	1.3	-0.5	-0.9	-0.9
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.1	0.1	1.1	-1.1	0.6
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.1	0.4	-0.4	-0.2	-0.1
High cholesterol (Self-reported)	0.2	0.4	0.9	0.6	0.3	-0.9	-0.4
Medication: Bendroflumethiazide	0.4	0.6	1.6	-0.3	0.8	-0.1	1.3
Medication: Paracetamol	0.3	0.5	1.4	-1.2	0.5	0.2	-0.5
Medication: Lisinopril	0.3	0.3	0.4	0.5	0.5	-0.6	0.6
Medication: Atorvastatin	0.2	0.2	0.4	0.6	-0.5	-0.0	-0.6
Illnesses of father: High blood pressure	0.3	0.4	1.5	-0.1	-0.3	1.2	0.2
Alcohol drinker status: Never	2.5	3.0	5.2	2.3	-1.4	-1.6	-1.6
Ever smoked	1.9	3.4	6.7	1.2	-2.6	-0.4	-2.3
Basal metabolic rate	0.6	3.5	5.5	1.8	-1.9	-2.3	-1.2
Leg fat percentage (left)	1.5	5.5	11.2	2.3	-1.2	-3.3	-2.0
Arm fat-free mass (left)	0.6	2.9	5.3	1.8	-1.5	-2.3	-1.0
Number of operations (self-reported)	0.7	1.1	1.7	1.0	-1.3	-0.9	-0.9
Average weekly beer plus cider intake	1.1	1.5	3.5	-1.9	0.4	1.6	0.1
Irritability	0.1	0.2	0.3	-0.5	-0.5	0.6	-0.4
Risk taking	0.5	0.7	1.8	0.9	0.1	-1.3	0.6
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.8	0.2	-0.9	0.5	-0.4
Fractured/broken bones in last 5 years	0.7	0.9	1.2	0.9	-1.0	-0.8	-1.1
Age started oral contraceptive pill	2.4	3.0	7.0	-1.0	2.7	-1.0	1.8
Diastolic blood pressure, automated reading	0.2	0.6	1.5	1.2	0.1	-0.8	0.5
Ever depressed for a whole week	1.2	1.5	4.7	-0.6	-0.2	2.2	-0.9
Unable to work because of sickness or disability	0.9	1.1	2.5	1.3	-0.3	-1.6	-0.4
Commuting to job workplace: Cycle	1.2	1.4	2.2	1.2	-1.5	-1.2	-0.7
Myopia	0.1	0.1	0.2	-0.4	0.3	0.5	-0.1
Vascular/heart problems diagnosed by doctor	0.6	1.7	3.7	-0.2	-1.7	0.4	-1.9
Cholesterol lowering medication	0.1	0.1	0.2	-0.2	0.1	-0.3	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.5	0.4	-1.2	-0.3	-0.7
Pain experienced in last month	0.3	0.5	1.5	-0.5	0.3	0.1	1.2
Supplements: Calcium	0.2	0.2	0.5	-0.5	-0.2	-0.3	0.7
Basal cell carcinoma (self-reported)	0.4	0.5	1.0	-1.0	0.1	1.0	0.0
Heart attack/myocardial infarction (self-reported)	1.3	1.6	2.8	-1.0	1.7	1.0	1.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.0	-1.0	0.5	0.9	0.8
Heart disease (siblings)	0.2	0.2	0.4	-0.1	0.6	0.5	0.3
Alcohol drinker status: Previous	0.2	0.2	0.6	-0.1	-0.5	0.8	0.1
Pack years of smoking	0.5	0.8	1.2	1.1	-0.5	-1.0	-0.9
Impedance of whole body	0.0	0.0	0.1	-0.3	0.1	-0.1	0.1
Leg fat mass (left)	1.3	4.9	7.8	2.2	-1.6	-2.8	-2.0
Arm predicted mass (left)	0.5	2.6	5.3	1.7	-1.3	-2.3	-0.9