Hub : Genes

IER2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Hypothalamus	0.3610	0.1070	0.00500	0.058	NA	-0.010	NA	0.038	0.018	NA	6.3e-01	NA	0.04500
2	GTEx	Cells Transformed fibroblasts	0.1820	0.0530	0.00095	0.003	NA	0.064	NA	0.042	0.170	NA	1.5e-05	NA	0.00043
3	GTEx	Muscle Skeletal	0.0785	0.0326	0.00550	-0.002	NA	-0.001	NA	-0.002	0.700	NA	4.6e-01	NA	0.66000
4	NTR	Blood	0.0274	0.0114	0.00690	0.000	0.004	0.004	0.007	0.007	0.220	0.010	1.2e-02	0.002	0.00250
5	TCGA	Lung Adenocarcinoma	0.0562	0.0268	0.00140	0.002	0.005	0.012	NA	0.002	0.170	0.076	1.3e-02	NA	0.19000

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.9	1.4	5.1	-0.8	-0.5	0.9	-2.2	0.0
Bipolar Disorder or Schizophrenia	1.8	4.3	16.8	-0.0	-0.8	2.1	-4.1	0.0
Depressed Affect (Nagel 2018)	0.4	0.9	1.4	1.2	1.2	1.0	-0.8	-0.4
Depression (Nagel 2018)	0.7	1.0	3.9	0.5	-0.8	0.2	-2.0	0.5
Intelligence (Savage-Jansen 2018)	1.4	4.2	14.7	-0.1	-2.0	-3.8	0.7	1.3
Neuroticism (Nagel 2018)	0.4	0.9	2.4	0.5	0.8	1.6	-1.0	0.0
Schizophrenia (2018)	1.7	3.6	13.8	0.6	-0.6	1.8	-3.7	0.0
Schizophrenia vs Biploar Disorder	1.4	1.8	4.4	1.5	-0.9	-2.1	-1.2	0.0
Worry (Nagel 2018)	0.7	1.4	3.5	-0.1	0.5	1.9	-1.7	-0.5
Alzheimer’s Disease (in mother)	0.1	0.1	0.5	0.1	0.2	-0.4	-0.7	-0.1
Alzheimer’s Disease (in father)	0.7	0.7	1.6	-1.2	-1.1	0.6	-0.2	-0.6
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	-0.7	-0.2	0.1	0.3	-0.9
Crohns Disease (2017)	0.3	0.7	2.4	0.3	1.6	0.2	-0.0	1.0
Irritable Bowel Disease (IBD)	0.3	0.7	1.6	0.6	1.2	1.3	0.2	-0.0
Ulcerative Colitis (UC)	0.4	0.8	1.5	0.4	1.0	1.2	0.4	-1.2
Major Depression (MDD)	0.6	0.7	1.7	0.3	-1.2	-0.4	-1.3	0.0
Reaction Time	1.0	1.8	6.2	-2.5	-0.6	1.4	-0.0	-0.8
Verbal and Numeric Reasoning (VNR)	2.2	5.2	11.7	-0.3	-3.4	-3.3	1.0	1.4
Breast Cancer	4.3	10.3	42.9	1.7	-1.8	-6.5	-1.1	-1.1
Ovarian Cancer	0.2	0.3	0.8	0.3	0.9	-0.3	0.6	-0.5
Prostate Cancer	0.2	0.2	0.5	0.1	-0.7	0.6	0.4	-0.2
Age at First Birth	0.4	0.6	1.6	-1.3	-0.4	-0.9	0.7	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.5	1.8	-1.3	0.4	0.4	0.5	0.0
Coronary Artery Disease (CAD)	0.2	0.2	1.2	0.0	0.0	0.0	-1.1	0.0
Crohns Disease (2012)	0.3	0.4	1.8	-0.5	-0.3	-0.2	1.3	0.0
Mean Putamen Volume	1.1	1.3	4.1	0.7	-1.3	-0.3	2.0	0.3
Fasting Glucose	0.5	0.6	0.9	-1.0	-0.9	-0.6	0.8	-0.3
HbA1C	0.4	0.5	1.1	-0.9	-0.4	1.1	0.5	0.2
HDL Cholesterol	0.6	0.9	2.3	1.5	1.2	0.2	-0.9	0.0
LDL Cholesterol	1.8	2.8	7.3	-0.3	-0.0	2.7	-2.5	0.0
Lupus	0.8	1.2	2.2	1.5	0.4	-1.1	-1.4	0.4
Neuroticism (2016)	0.8	1.2	2.6	-1.4	1.6	1.0	-0.4	-0.5
Primary Biliary Cirrhosis	2.0	2.8	10.8	1.0	-0.4	-3.3	0.7	-1.2
Rheumatoid Arthritis	1.7	2.4	9.8	-0.4	-0.5	-3.1	-1.3	0.0
Schizophrenia (2014)	2.0	4.5	15.7	1.5	-0.5	2.1	-4.0	0.0
Triglycerides	0.3	0.5	1.7	-1.3	-0.9	0.2	-0.4	0.0
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.7	0.8	0.8	0.0	0.6	0.0
Ulcerative Colitis	0.3	0.4	0.7	-0.8	-0.5	0.7	-0.7	0.0
Blood Eosinophil Count	0.3	2.3	5.2	1.5	-0.8	-2.3	-1.3	1.4
Blood Platelet Count	0.3	4.0	13.9	-0.7	0.3	-2.3	-3.7	-0.2
Blood Red Count	2.6	25.4	102.0	-1.1	-0.9	-10.1	4.7	-1.1
Blood White Count	0.2	1.6	5.2	0.6	0.0	0.7	-2.3	1.4
Heel T-Score	1.2	9.4	41.0	-0.2	1.1	1.6	6.4	1.5
BMI	0.5	2.8	6.5	-0.3	-1.1	-2.5	0.9	-2.3
Height	0.3	5.0	10.3	-1.2	-0.7	3.2	2.5	-2.5
Waist Hip Ratio (WHR)	0.5	2.1	5.2	-2.3	1.2	1.9	0.2	-0.4
Systolic Blood Pressure	0.5	2.4	8.5	-0.4	2.9	-1.9	0.1	-0.2
Smoking Status	0.9	2.1	8.6	-0.2	-0.2	2.9	-0.8	1.2
Allergy or Eczema	0.2	0.5	0.7	0.9	-0.8	-0.2	0.8	-0.6
Cardiovascular Disease	0.6	2.0	7.9	1.3	0.1	-2.8	-0.1	-0.8
Hypothyroidism (self reported)	0.2	0.5	1.1	-0.4	-0.1	1.0	-0.4	-1.0
Respiratory disease	0.6	1.3	4.5	0.4	-0.6	-2.1	0.3	-1.1
Type 2 Diabetes (T2D) (2018)	2.0	3.8	13.3	1.3	-0.3	-3.6	1.7	-1.1
Lung FEV1/FVC ratio	0.3	1.4	2.8	-1.1	0.2	1.5	1.7	-0.7
Lung FVC	0.1	0.8	2.1	-0.7	0.8	1.4	-0.1	0.7
Neuroticism	0.4	1.1	2.5	-0.2	0.9	1.6	-0.9	-1.0
Chronotype (morning person)	0.9	2.1	4.4	2.1	-1.6	0.5	-1.8	-0.4
Hair Pigment	0.1	3.3	10.4	2.1	-0.6	3.2	0.3	-1.0
Tanning	0.0	0.5	1.9	-0.1	0.6	0.5	-0.2	1.4
Hand grip strength (left)	1.7	4.5	17.6	-0.0	1.1	4.2	2.0	0.3
Number of treatments/medications taken	1.0	1.8	3.1	1.7	-1.8	-1.2	0.6	-1.0
Average weekly spirits intake	0.2	0.3	0.4	0.5	0.5	-0.1	-0.6	-0.7
Sensitivity / hurt feelings	0.8	1.4	2.5	-1.6	1.6	1.3	0.1	0.2
Frequency of depressed mood in last 2 weeks	0.5	0.6	0.9	-0.7	-0.9	0.7	-1.0	0.7
Hearing difficulty/problems: Yes	0.6	0.9	2.5	-0.8	-1.6	-0.6	-0.2	1.0
Relative age of first facial hair	0.9	1.9	4.5	-1.4	1.4	2.1	-0.6	0.9
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.7	1.6	-0.9	0.4	-0.4	-1.3
Ever used hormone-replacement therapy (HRT)	0.5	0.6	0.8	-0.6	-0.9	-0.9	-0.7	0.7
Ever had hysterectomy (womb removed)	4.4	5.0	14.5	3.8	-1.7	-2.7	-0.1	-0.5
Systolic blood pressure, automated reading	0.2	0.5	1.2	0.1	1.1	-1.1	-0.1	0.5
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	5.8	-0.4	1.7	-0.3	0.0	-2.4
Angina	0.5	0.6	1.2	0.6	-1.1	-0.6	0.3	-1.1
Medication for hormone replacement therapy	1.5	1.7	4.9	-0.7	-1.4	-2.2	-1.0	-0.6
Vitamin and mineral supplements	1.0	1.4	3.0	1.7	0.4	-0.7	0.4	-1.7
Supplements: Zinc	0.8	0.9	2.4	0.1	-0.2	1.5	1.2	-0.7
Medication: Co-codamol	0.5	0.6	2.6	0.2	-0.1	-1.6	0.3	-0.4
Medication: Metformin	2.5	3.5	15.6	-0.2	0.0	-3.9	0.9	-1.0
Diabetes (father)	1.4	1.7	4.8	-2.2	0.8	-1.0	1.4	0.5
Diabetes (mother)	2.4	3.0	7.0	-1.4	2.6	-2.3	-0.7	0.3
Severe depression (siblings)	0.9	1.0	2.9	-1.7	-1.3	0.2	-0.3	0.7
Pack years adult smoking proportion	0.3	0.5	1.0	0.7	-0.8	0.2	0.5	-1.0
Impedance of leg (right)	0.6	2.9	7.2	0.6	2.0	1.4	-2.7	1.0
Leg fat-free mass (left)	0.6	3.1	8.6	-1.8	-0.6	0.5	2.9	-1.7
Trunk fat percentage	0.3	1.3	4.4	-1.3	0.4	-0.3	-0.2	-2.1
Hand grip strength (right)	1.8	4.9	14.4	-0.9	0.9	3.8	2.9	0.6
Townsend deprivation index at recruitment	0.2	0.3	0.6	-0.6	0.0	0.8	0.8	0.3
Current tobacco smoking	0.2	0.4	0.6	0.6	0.5	0.8	-0.5	0.7
Average weekly fortified wine intake	1.6	1.9	5.2	1.7	1.0	-0.7	-0.5	-2.3
Maternal smoking around birth	1.7	2.4	5.7	2.4	1.5	0.5	1.4	1.4
Fed-up feelings	0.5	0.9	1.8	-1.1	1.0	1.3	-0.5	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.2	-1.1	-0.3	-0.2	-0.7	1.1
Relative age voice broke	1.7	2.7	10.2	-1.3	0.4	3.2	-0.4	1.1
Taking other prescription medications	0.6	0.9	2.8	0.1	-1.1	-0.5	-0.0	-1.7
Age when periods started (menarche)	0.5	1.1	3.9	-0.1	-1.2	2.0	-0.6	-0.2
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	3.4	1.4	-1.2	-1.9	-1.5	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	5.6	-0.8	1.7	1.0	1.4	2.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.3	0.1	-0.5	0.9	1.1	0.3
Qualifications: CSEs or equivalent	2.3	3.1	5.1	-2.0	2.3	1.7	1.7	-0.7
Serious illness, injury or assault to yourself	0.8	0.9	1.4	0.4	0.8	-1.2	-1.2	-1.0
High blood pressure	0.5	1.3	5.6	0.5	-0.4	-2.4	0.0	-0.7
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.1	1.0	0.4	0.1	1.0	-0.9
Multivitamins +/- minerals	2.2	2.9	9.1	-0.9	-0.8	1.9	-0.2	3.0
Stomach or abdominal pain in last month	1.2	1.5	5.1	0.6	-2.3	0.5	-0.1	-1.3
Supplements: Glucosamine	0.2	0.2	0.5	-0.2	0.2	0.6	0.2	0.7
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.7	0.3	0.9	0.7	0.8	-0.7
Medication: Atenolol	0.8	1.0	2.4	-0.4	-0.5	-1.5	0.0	-1.6
Medication: Levothyroxine sodium	0.7	1.3	3.2	-0.9	-0.3	0.3	-1.8	-1.4
Sitting height	0.5	3.6	8.4	-1.0	-0.4	-2.9	0.8	-2.7
Chronic bronchitis/emphysema (father)	1.5	1.7	5.9	1.4	-0.8	2.4	0.4	-0.2
High blood pressure (mother)	0.4	0.5	2.1	-0.5	-0.5	-0.1	1.4	0.1
Body mass index (BMI)	0.4	1.6	3.7	-1.3	-0.1	-0.6	1.9	-1.5
Impedance of leg (left)	0.5	2.6	7.7	0.8	1.8	1.0	-2.8	0.5
Leg predicted mass (left)	0.6	3.2	8.9	-1.9	-0.6	0.5	3.0	-1.7
Trunk fat mass	0.4	1.8	5.4	-1.7	0.2	-0.1	0.8	-2.3
Waist circumference	0.5	1.7	3.5	-1.7	0.5	-0.3	1.4	-1.9
Number of incorrect matches in round	0.1	0.1	0.3	0.6	0.2	0.1	-0.2	0.5
Past tobacco smoking	1.1	1.9	4.0	1.4	0.5	-2.0	1.8	-0.4
Alcohol usually taken with meals	0.6	0.9	2.3	-0.4	-0.8	-1.2	-1.5	-0.3
Nervous feelings	1.9	3.6	10.4	-0.7	0.0	3.2	-2.6	-0.7
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	7.5	-2.7	-0.9	0.2	-0.9	0.1
Hearing difficulty/problems with background noise	0.8	1.3	3.2	-1.8	-1.6	-0.8	0.0	-0.3
Hair/balding pattern: Pattern 2	1.2	1.5	3.1	-1.8	-0.3	1.0	1.4	-1.2
Had menopause	0.9	1.2	3.2	1.8	-0.8	-1.0	0.3	-1.0
Had other major operations	0.5	0.6	1.9	1.4	-0.7	0.3	-0.6	0.2
Forced vital capacity (FVC)	0.4	1.4	4.9	-1.2	0.6	2.2	0.4	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	4.8	-1.0	1.2	1.2	0.4	2.2
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.4	-1.5	-1.5	0.5	-0.5	-0.4
Qualifications: None of the above	1.5	3.2	13.2	-0.2	1.4	3.6	0.5	-0.7
Financial difficulties in last 2 years	1.8	2.5	6.8	0.8	-2.6	-1.8	-1.1	0.8
Mouth/teeth dental problems	1.8	2.8	5.5	2.3	-0.8	1.9	-2.0	0.6
Heart attack	0.9	1.1	4.5	-0.0	-0.2	-0.8	2.1	-0.5
Allergy	0.3	0.7	1.9	-1.4	-0.7	0.0	-0.9	0.6
Pain all over the body in last month	1.3	1.4	5.3	2.3	-0.5	-0.2	0.3	-1.2
Diabetes (self-reported)	3.0	4.6	17.7	-0.0	0.2	-4.2	0.5	-2.3
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.7	0.4	-0.5	-1.3	1.1	-0.7
Medication: Ramipril	1.6	2.0	5.1	0.1	-1.2	-2.2	-1.5	-1.2
Medication: Simvastatin	1.4	2.0	5.4	-0.2	-1.3	-0.6	1.6	-2.3
Fluid intelligence score	2.6	5.5	15.1	-0.7	-3.9	-2.8	1.3	1.6
Illnesses of siblings	0.0	0.1	0.2	-0.2	-0.2	0.4	0.2	-0.1
Neuroticism score	0.7	1.5	3.1	-1.3	1.3	1.7	-1.0	-0.4
Weight	0.6	3.0	5.8	-1.9	-0.2	0.1	2.4	-2.3
Impedance of arm (right)	0.8	3.5	9.4	0.7	2.1	1.8	-3.1	-0.1
Arm fat percentage (right)	0.3	1.0	2.7	-1.2	0.9	0.1	0.3	-1.6
Trunk fat-free mass	0.6	3.6	12.3	-1.4	-0.6	0.8	3.5	-1.7
Hip circumference	0.4	1.8	4.1	-0.9	0.6	-1.5	1.1	-2.0
Time employed in main current job	0.9	1.0	2.4	1.5	0.7	0.9	1.1	0.3
Alcohol intake versus 10 years previously	0.8	1.1	3.2	0.5	-0.8	1.1	0.6	-1.8
Father’s age at death	0.5	0.7	2.3	1.1	0.0	0.3	-1.5	0.3
Worrier / anxious feelings	1.2	2.2	5.8	-1.0	2.4	2.0	-0.2	-0.3
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	2.9	-1.7	-0.4	1.6	-1.4	-0.8
Falls in the last year	0.7	0.9	3.1	0.8	0.6	1.8	-0.3	-0.7
Hair/balding pattern: Pattern 3	0.9	1.4	3.9	0.0	-0.5	-2.0	0.8	1.5
Number of live births	0.6	0.9	2.7	0.6	1.0	1.6	0.2	0.4
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	8.7	-1.3	1.3	3.0	0.6	-0.7
Pulse rate	0.5	0.9	2.6	-0.5	-0.3	0.8	1.6	0.9
Happiness	2.0	2.5	8.8	-0.4	-1.8	-0.5	-3.0	0.0
Noisy workplace	1.8	2.2	4.3	-0.8	1.3	2.1	1.4	-1.5
Qualifications: A levels/AS levels or equivalent	1.9	4.1	11.0	1.5	-1.4	-3.3	-1.8	1.4
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.4	-0.8	-0.5	1.6	0.5	-0.3
Mouth/teeth dental problems: Dentures	0.4	0.7	2.7	-0.3	-0.2	-1.7	0.7	-0.3
Asthma	0.5	1.0	4.0	2.0	0.4	-0.7	-0.2	-0.6
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	3.8	2.0	-1.0	1.8	1.2	0.3
Medication: Cholesterol lowering	2.5	3.8	8.5	-1.1	-2.9	-0.2	1.1	-2.9
Depression (self-reported)	1.2	1.4	4.4	-1.5	0.4	-0.6	0.3	2.1
Medication: Lansoprazole	1.8	2.1	4.7	0.4	-0.5	2.0	-1.2	-2.2
Prospective memory result	1.7	2.0	5.9	-0.3	1.1	0.8	-1.5	-2.4
Lung cancer (father)	0.9	1.0	3.6	-0.8	0.8	0.3	1.9	0.6
Illnesses of mother	0.2	0.3	0.9	-1.0	-0.0	0.3	-0.7	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	3.3	-1.8	1.2	1.6	1.4	-1.0
Pulse wave Arterial Stiffness index	0.4	0.5	1.7	-0.3	-0.4	0.5	1.3	0.2
Impedance of arm (left)	0.7	3.0	11.4	0.6	1.1	1.4	-3.4	0.4
Arm fat mass (right)	0.4	1.5	3.6	-1.5	0.4	0.1	1.3	-1.9
Trunk predicted mass	0.6	3.6	12.3	-1.3	-0.6	0.8	3.5	-1.7
Standing height	0.2	2.1	3.3	-1.4	-0.2	1.7	1.4	-1.8
Length of working week for main job	1.5	1.6	5.4	0.5	1.5	0.4	2.3	-0.1
Exposure to tobacco smoke at home	0.5	0.5	1.3	0.6	0.6	-1.1	0.5	-0.7
Breastfed as a baby	0.8	1.0	2.2	1.5	1.2	0.9	-0.8	0.1
Tense / ‘highly strung’	0.6	0.9	2.8	-1.1	-0.4	0.5	-1.7	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.7	4.7	-1.4	-1.5	2.2	-1.1	1.8
Hair/balding pattern: Pattern 4	0.3	0.8	2.3	1.5	1.1	0.4	0.3	0.7
Birth weight of first child	0.2	0.3	0.5	0.5	0.7	0.7	0.2	-0.2
Peak expiratory flow (PEF)	0.8	1.9	7.0	-0.1	1.1	2.7	-0.3	-1.0
Pulse wave reflection index	0.1	0.2	0.5	0.7	-0.4	-0.1	-0.2	-0.1
Ever highly irritable/argumentative for 2 days	1.3	1.6	2.6	-1.5	0.8	0.3	1.5	-1.6
Loud music exposure frequency	1.1	1.3	2.0	-1.3	0.9	0.9	-0.9	-1.4
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	3.5	0.8	-0.1	-1.9	-0.3	0.2
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	6.2	-1.1	1.2	0.3	2.5	-0.6
Blood clot in the leg (DVT)	1.0	1.3	2.8	0.1	1.5	-1.7	0.5	-1.1
Medication: Paracetamol	0.2	0.3	0.8	0.1	0.9	0.3	0.3	-0.8
Headache pain in last month	0.7	1.3	2.5	-0.7	-1.1	1.0	-1.6	-1.0
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	3.3	0.7	1.8	0.2	-1.2	1.8
Glaucoma (self-reported)	2.7	3.2	10.1	3.2	-0.9	0.0	-2.0	-1.1
Gout (self-reported)	0.6	0.8	2.2	-0.4	0.8	-0.8	0.7	1.5
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	1.6	-1.1	-0.7	0.8	-1.2	-1.3
Medication: Amlodipine	0.3	0.4	1.1	0.7	-0.4	-1.0	-0.4	0.0
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.2	1.5	-0.5	0.8	-1.1	-0.2
Birth weight	0.2	0.5	1.7	-1.3	0.3	-0.6	-0.5	-0.0
Chronic bronchitis/emphysema (mother)	0.5	0.5	2.0	1.4	0.0	0.2	0.8	-0.1
High blood pressure (siblings)	0.2	0.3	0.9	-0.6	0.2	-0.0	-0.3	0.9
Forced vital capacity (FVC), Best measure	0.3	1.0	1.6	-1.2	0.6	0.7	1.3	-1.1
Body fat percentage	0.3	1.2	2.9	-1.5	0.7	-0.2	-0.0	-1.7
Leg fat percentage (right)	0.3	0.9	2.7	-1.7	0.7	-0.0	0.6	-1.0
Arm fat-free mass (right)	0.6	3.1	9.0	-1.5	-1.0	-0.3	3.0	-1.8
Exposure to tobacco smoke outside home	1.1	1.5	5.3	-0.9	1.0	-2.3	-0.2	-0.3
Comparative body size at age 10	0.5	1.3	2.8	0.9	-1.0	1.1	0.7	1.7
Number of full brothers	1.1	1.4	4.7	-2.2	1.2	0.5	-0.5	0.6
Worry too long after embarrassment	0.7	1.2	2.5	-1.5	1.6	1.0	-0.5	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.0	4.7	-0.9	-2.2	-0.7	-1.8	0.9
Wheeze or whistling in the chest in last year	0.6	1.1	3.1	0.9	-1.8	-0.9	-0.5	-0.7
Number of children fathered	1.6	1.8	4.4	2.1	-0.8	1.8	-0.6	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.7	-0.7	0.0	0.8	-1.3	-0.4
Age at first live birth	0.6	1.0	3.4	0.4	-1.2	-1.8	0.3	-0.2
Pulse wave peak to peak time	0.4	0.4	1.6	0.4	0.2	-0.5	-1.3	-0.3
Health satisfaction	0.7	1.0	2.8	0.8	-0.3	1.7	1.1	-0.3
Shortness of breath walking on level ground	0.7	0.8	2.4	0.2	0.3	-0.5	1.1	-1.6
Qualifications: College or University degree	2.3	7.2	21.5	-0.3	-2.1	-4.6	-2.3	2.2
Eye problems/disorders: None of the above	2.0	2.3	8.3	-2.9	0.5	-0.2	-0.4	1.7
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.8	0.0	-0.3	-0.7	-0.1	0.9
Emphysema/chronic bronchitis	1.8	2.0	3.3	0.4	-1.7	-0.6	-1.8	1.8
Medication for pain relief, constipation, heartburn	1.7	2.9	5.7	-2.4	-0.1	-2.3	-0.9	1.6
Neck or shoulder pain in last month	0.2	0.4	0.8	-0.2	-0.7	0.1	0.7	-0.9
Medication: Blood pressure	0.4	0.7	2.0	-0.5	-1.4	-0.4	-0.1	-1.1
Angina (self-reported)	0.5	0.7	1.7	0.7	-0.7	-0.8	-0.0	-1.3
Migraine (self-reported)	3.1	3.8	17.3	-0.4	-4.2	0.4	-1.1	0.5
Medication: Ibuprofen	1.2	1.4	5.0	0.7	-0.4	2.2	1.3	-0.1
Medication: Allopurinol	1.1	1.5	3.3	0.5	1.3	-1.4	0.4	1.8
Medication: Omeprazole	1.9	2.3	5.0	-0.5	1.6	1.9	0.6	-2.2
Medication: Seretide 50 evohaler	0.9	1.0	3.0	1.0	-0.6	0.3	-1.7	-0.7
Mean time to correctly identify matches	0.8	1.6	4.3	-2.1	-1.3	0.6	-0.1	-1.3
Heart disease (mother)	0.8	0.9	2.9	-0.5	0.4	0.4	1.7	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.6	4.0	1.5	0.1	1.3	-2.0	0.1
Whole body fat mass	0.4	1.5	3.7	-1.6	0.3	0.3	1.0	-1.9
Leg fat mass (right)	0.4	1.6	3.6	-1.9	0.4	-0.0	1.5	-1.4
Arm predicted mass (right)	0.6	3.2	10.2	-1.6	-0.9	-0.4	3.2	-1.5
Pulse rate, automated reading	0.2	0.8	2.0	-1.4	-0.6	-0.9	0.1	0.9
Alcohol intake frequency.	0.9	2.0	3.8	-0.9	-1.5	1.6	0.8	-1.9
Comparative height size at age 10	0.2	0.9	1.9	0.4	0.5	1.2	1.0	-1.4
Number of full sisters	0.2	0.3	0.4	-0.5	-0.6	-0.5	0.2	0.7
Suffer from ‘nerves’	1.8	2.8	5.2	-1.5	1.3	2.3	-2.1	0.8
Overall health rating	0.6	1.3	1.8	-1.2	-1.1	1.2	-0.7	-1.3
Chest pain or discomfort	1.8	2.6	9.7	-0.7	-3.1	-0.9	-1.3	0.2
Had major operations	0.7	0.9	2.3	1.2	-1.5	-0.6	0.3	-0.3
Age at last live birth	0.4	0.6	1.4	-0.8	-1.2	-1.0	-0.1	0.3
Family relationship satisfaction	3.4	4.2	12.0	0.4	-3.5	-1.8	-1.6	1.6
Leg pain on walking	1.7	2.2	6.7	1.0	-0.6	0.2	1.7	-2.6
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	6.0	0.6	2.5	1.9	-0.9	-0.7
Commuting to job workplace: Car/motor vehicle	3.1	3.6	10.4	2.3	-3.2	-0.2	-0.5	1.3
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	4.0	-0.0	0.4	0.9	2.0	-1.5
Medication: Aspirin	0.5	0.7	1.7	1.2	-0.4	0.5	1.3	-0.3
Supplements: Vitamin C	1.0	1.2	4.9	-0.6	-0.1	0.6	-0.6	-2.2
Knee pain experienced in last month	0.7	1.1	2.8	-0.7	-0.1	1.0	-1.2	-1.7
Hypertension (Self-reported)	0.4	1.2	5.5	0.4	-0.4	-2.4	-0.3	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.6	3.0	8.3	-0.8	-1.3	2.9	-0.2	-2.1
Illnesses of father: Heart disease	0.3	0.5	2.1	0.1	-0.3	0.1	0.3	1.5
Illnesses of siblings: Diabetes	0.1	0.1	0.5	-0.3	0.1	0.7	-0.1	-0.2
Smoking status: Previous	1.9	2.8	6.5	-2.5	-0.5	2.3	-1.4	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	2.0	-1.4	1.1	1.2	1.2	-0.8
Whole body fat-free mass	0.6	3.7	11.8	-1.6	-0.7	0.6	3.4	-1.8
Leg fat-free mass (right)	0.6	3.1	8.8	-1.6	-0.8	0.2	3.0	-1.8
Arm fat percentage (left)	0.2	0.7	1.8	-1.1	0.5	-0.2	0.3	-1.3
Average weekly red wine intake	0.7	1.1	1.9	-0.5	-1.2	-1.0	-0.8	1.4
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.7	-0.8	-1.6	-1.3	-0.5	-0.7
Mood swings	0.9	1.6	5.6	-0.7	0.9	2.4	-0.9	0.5
Loneliness, isolation	0.5	0.7	2.1	0.0	-1.0	-1.4	-0.2	0.3
Long-standing illness, disability or infirmity	1.0	1.6	3.0	1.3	-1.7	-1.2	-0.2	-1.4
Ever had bowel cancer screening	0.4	0.5	1.1	0.5	-0.4	-1.0	0.8	-0.5
Diabetes diagnosed by doctor	3.1	5.1	21.6	-0.8	-0.2	-4.7	-0.1	-1.8
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.0	-1.4	0.7	1.1	-1.0	1.1
Friendships satisfaction	1.7	2.1	5.7	0.1	-2.4	-0.8	-2.0	-0.1
Qualifications: nursing, teaching	0.6	0.9	3.3	-0.1	-0.7	-1.8	-0.2	0.8
Commuting to job workplace: Walk	1.4	1.5	5.8	-0.8	2.4	1.0	-0.4	-0.1
Eye problems/disorders: Cataract	0.5	0.5	1.8	0.5	-0.1	-0.8	1.3	0.2
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	1.9	-0.3	1.4	-1.3	0.5	-1.3
Medication for cholesterol	2.1	3.1	14.1	0.1	0.4	3.8	0.1	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.8	0.0	0.1	0.1	0.9	-0.3
Back pain experienced in last month	0.7	1.0	2.6	-1.0	-1.0	0.5	-0.4	-1.6
Mineral and other dietary supplements	0.9	1.2	3.8	0.4	-0.7	-2.0	-1.2	0.0
Breast cancer (self-reported)	1.7	2.0	7.2	0.8	0.7	2.7	-0.8	1.1
Asthma (self-reported)	0.6	1.2	4.1	2.0	0.6	-0.9	0.1	-0.7
Osteoporosis (self-reported)	0.6	0.7	1.1	0.9	1.0	0.8	0.9	-0.5
Osteoarthritis (self-reported)	0.5	0.6	1.3	0.8	-1.1	-1.0	0.2	-0.2
Medication: Aspirin	0.7	0.9	1.9	1.3	-0.8	0.2	1.4	-0.1
Medication: Gliclazide	2.2	2.5	8.9	-0.3	-0.7	-3.0	1.3	-1.1
Illnesses of father: None of the above (group 1)	1.7	2.0	4.9	-0.9	0.7	-0.6	-1.9	-2.2
Smoking status: Current	0.3	0.5	0.9	0.9	1.0	0.7	-0.2	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	3.2	-0.8	0.7	0.5	1.8	-0.1
Whole body water mass	0.6	3.7	11.7	-1.4	-0.7	0.4	3.4	-2.0
Leg predicted mass (right)	0.6	3.0	8.8	-1.6	-0.8	0.3	3.0	-1.8
Arm fat mass (left)	0.4	1.6	3.7	-1.6	0.5	-0.1	1.2	-1.9
Number of self-reported non-cancer illnesses	1.0	1.8	4.7	1.4	-1.5	-0.4	0.2	-2.2
Average weekly champagne plus white wine intake	0.6	0.8	2.2	1.5	-0.8	-0.5	-0.4	0.7
Miserableness	0.2	0.3	1.3	1.1	0.3	-0.3	-0.4	0.2
Guilty feelings	0.7	1.1	2.9	-1.2	-0.5	1.7	-0.5	-0.7
Wears glasses or contact lenses	1.7	2.0	5.2	2.3	0.2	-1.1	-0.5	1.8
Ever taken oral contraceptive pill	1.6	1.8	5.4	-2.3	0.4	0.6	1.0	1.4
Hearing aid user	0.3	0.3	1.2	0.3	-0.3	-0.5	-1.1	0.4
Mother’s age at death	1.2	1.5	3.9	0.6	-2.0	0.1	-1.8	-0.3
Financial situation satisfaction	2.0	2.4	6.7	-1.5	-2.6	-1.5	-0.4	-1.0
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.3	-1.1	-0.6	0.1	0.1	-0.2
Commuting to job workplace: Public transport	1.8	2.1	3.0	-1.7	0.9	-1.5	1.4	1.6
Eye problems/disorders: Glaucoma	2.7	3.2	13.4	3.7	-0.8	0.7	-0.7	-1.0
Medication: Blood pressure	0.9	1.8	8.8	-0.2	0.2	-3.0	0.3	0.2
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.2	1.1	-1.0	-0.6	-0.7	-1.1
Supplements: Fish oil (including cod liver oil)	1.4	1.8	3.4	-0.7	1.8	1.7	1.4	-0.5
High cholesterol (Self-reported)	1.1	2.0	6.7	-0.0	-1.5	0.7	0.7	-2.6
Medication: Bendroflumethiazide	0.6	0.9	2.1	-1.1	-0.7	-1.5	-0.1	0.8
Medication: Paracetamol	0.1	0.1	0.3	0.2	0.3	0.3	-0.2	-0.6
Medication: Lisinopril	0.4	0.6	1.2	-0.9	-0.8	-1.1	-0.5	-0.1
Medication: Atorvastatin	1.1	1.4	4.8	-1.1	-0.1	-0.8	-0.5	-2.2
Illnesses of father: High blood pressure	0.7	0.9	3.2	0.1	-0.4	0.1	1.0	1.8
Alcohol drinker status: Never	0.5	0.6	1.3	-0.2	-1.2	1.1	0.2	-0.7
Ever smoked	1.4	2.4	6.1	-0.9	-0.5	2.5	-2.1	0.5
Basal metabolic rate	0.6	3.4	9.7	-1.7	-0.4	0.5	3.1	-2.0
Leg fat percentage (left)	0.2	0.8	2.0	-1.4	0.3	-0.4	0.3	-1.4
Arm fat-free mass (left)	0.7	3.7	8.7	-2.1	-0.5	0.1	2.9	-2.3
Number of operations (self-reported)	1.4	2.0	3.8	1.4	-2.0	-0.6	0.6	-1.9
Average weekly beer plus cider intake	4.1	6.0	12.8	-0.3	2.4	3.6	3.0	1.5
Irritability	0.3	0.5	0.9	1.0	0.7	0.6	-0.2	-0.8
Risk taking	1.2	1.8	3.5	1.2	-1.9	-1.4	-1.2	0.6
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.8	0.2	-1.1	-0.6	-1.4	0.3
Fractured/broken bones in last 5 years	0.9	1.2	1.7	-1.3	-0.9	-1.2	-1.2	-0.7
Age started oral contraceptive pill	1.2	1.5	5.2	0.3	-2.3	-1.4	-0.3	-0.4
Diastolic blood pressure, automated reading	0.4	1.4	5.0	-2.2	0.6	-1.1	0.5	0.2
Ever depressed for a whole week	0.6	0.8	2.6	0.2	-1.6	0.7	-0.6	0.6
Unable to work because of sickness or disability	1.0	1.3	1.8	0.6	-1.4	-1.2	-1.3	1.1
Commuting to job workplace: Cycle	1.9	2.3	5.3	0.2	1.2	-1.7	-2.3	-1.4
Myopia	1.2	1.7	4.5	1.1	1.3	-2.1	-0.5	1.0
Vascular/heart problems diagnosed by doctor	0.6	1.6	6.7	-0.3	0.3	2.6	-0.5	1.0
Cholesterol lowering medication	0.6	0.9	2.9	-0.4	0.3	-1.0	0.7	-1.7
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	2.8	0.6	1.0	1.5	0.6	-1.7
Pain experienced in last month	1.9	3.2	9.2	-0.7	2.4	0.3	-0.8	3.0
Supplements: Calcium	0.2	0.3	0.7	0.8	-0.1	0.1	-0.6	-0.5
Basal cell carcinoma (self-reported)	1.0	1.2	2.1	1.2	0.5	1.2	-1.5	0.7
Heart attack/myocardial infarction (self-reported)	0.8	1.1	4.3	-0.1	-0.2	-0.9	2.1	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	2.2	-0.0	1.4	-1.5	0.2	-1.1
Heart disease (siblings)	0.5	0.6	1.2	0.4	-0.9	0.0	1.0	1.1
Alcohol drinker status: Previous	3.7	4.2	18.8	-0.4	-0.9	4.3	-0.9	-0.7
Pack years of smoking	0.5	0.7	1.3	1.0	-1.1	0.2	0.3	-1.1
Impedance of whole body	0.6	2.9	10.3	0.5	1.6	1.1	-3.2	0.3
Leg fat mass (left)	0.4	1.5	3.1	-1.8	0.1	-0.2	1.4	-1.6
Arm predicted mass (left)	0.7	3.5	9.5	-1.9	-0.4	-0.1	3.1	-2.0