TWAS hub - TMEM91

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.078	0.0350	0.0091	-0.003	NA	0.008	NA	0.000	7.0e-01	NA	7.4e-02	NA	3.1e-01
2	GTEx	Esophagus Muscularis	0.136	0.0580	0.0083	-0.003	NA	-0.004	NA	-0.005	5.9e-01	NA	6.4e-01	NA	9.6e-01
3	GTEx	Heart Atrial Appendage	0.119	0.0480	0.0060	0.053	NA	0.060	NA	0.081	2.1e-03	NA	1.1e-03	NA	1.8e-04
4	GTEx	Small Intestine Terminal Ileum	0.309	0.1030	0.0027	-0.013	NA	0.041	NA	0.019	8.6e-01	NA	4.3e-02	NA	1.2e-01
5	GTEx	Testis	0.236	0.0910	0.0057	0.185	NA	0.178	NA	0.189	1.2e-08	NA	2.4e-08	NA	8.6e-09
6	YFS	Blood	0.501	0.0395	0.0000	0.049	0.221	0.253	0.235	0.228	9.5e-16	9.7e-71	5.3e-82	1.6e-75	4.5e-73

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Hair/balding pattern: Pattern 4	6.4	15.4	35.8	-6.0	-4.0	-4.3	0.1	3.6	-3.2
Height	4.1	79.2	148.8	11.5	6.7	12.2	-0.3	-5.9	10.7
Comparative height size at age 10	3.7	20.1	40.6	5.5	3.3	6.4	-0.3	-3.4	5.2
Myopia	3.6	5.2	10.9	2.6	2.5	3.3	1.0	-0.8	2.4
Hair/balding pattern: Pattern 3	3.5	5.3	11.8	-3.4	-2.0	-2.7	-0.3	1.2	-2.6
Standing height	3.4	33.5	62.7	6.9	4.9	7.9	-0.5	-4.2	6.9
Headache pain in last month	3.2	5.4	11.5	-3.4	-1.1	-3.0	0.7	2.6	-1.9
Heel T-Score	3.0	23.6	68.1	-8.2	-2.8	-4.2	-2.0	-0.5	-6.7
Eye problems/disorders: Glaucoma	2.9	3.4	10.4	-2.4	-1.3	-3.2	-0.8	1.3	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	2.7	3.5	11.4	2.5	-0.5	-0.9	3.4	0.9	1.3
Alcohol drinker status: Never	2.7	3.2	6.1	2.5	1.5	1.7	0.0	-1.7	2.2
Sitting height	2.4	16.9	31.9	5.4	2.5	5.6	-0.5	-3.3	4.8
Birth weight	2.4	5.2	10.5	3.2	0.2	1.2	2.7	1.9	2.9
Prostate Cancer	2.3	3.2	7.7	-2.2	-1.8	-1.6	0.5	0.5	-2.8
HbA1C	2.3	2.5	9.5	0.9	-1.2	-0.6	0.9	3.1	1.5
Heart disease (siblings)	2.3	2.8	8.3	1.6	-0.0	2.3	-1.0	-2.9	-0.2
Mouth/teeth dental problems: Bleeding gums	2.2	2.8	6.6	2.6	0.9	1.6	0.5	0.9	2.5
Migraine (self-reported)	2.2	2.8	8.0	-0.7	-2.8	-1.1	2.3	0.9	-1.0
Heart disease (mother)	2.1	2.6	8.1	0.5	-0.0	1.2	-2.9	-2.3	-0.5
Angina	2.0	2.6	6.9	2.6	0.2	1.6	-0.6	-0.3	2.3
Glaucoma (self-reported)	2.0	2.3	7.1	-2.0	-0.8	-2.7	0.0	1.5	0.2
Supplements: Vitamin C	1.9	2.3	3.7	1.6	0.8	1.4	1.9	1.2	1.8
Average weekly champagne plus white wine intake	1.9	2.6	7.0	-2.2	-2.6	-1.2	-0.3	1.4	-0.7
Happiness	1.8	2.2	6.9	2.6	0.7	0.8	1.1	1.1	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	7.2	-2.7	0.4	-1.8	0.8	0.9	-0.9
Ever had hysterectomy (womb removed)	1.7	2.0	4.9	0.8	-1.3	-0.6	-2.2	-2.0	-0.4
Heart attack	1.7	2.2	6.9	2.6	-0.5	0.9	0.2	-0.2	2.3
Number of live births	1.7	2.3	8.1	1.8	1.3	0.7	0.5	0.4	2.9
Supplements: Fish oil (including cod liver oil)	1.7	2.3	10.2	0.4	-0.8	0.0	0.7	3.2	1.4
Sensitivity / hurt feelings	1.6	2.7	8.2	2.9	0.6	-0.4	0.6	1.1	2.4
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	5.8	2.0	0.3	0.8	-1.2	-2.4	0.3
Medication: Ibuprofen	1.6	2.0	8.0	-0.6	0.0	-0.9	-1.2	2.8	1.1
Coronary Artery Disease (CAD)	1.5	1.8	7.7	2.8	0.9	0.5	0.5	0.0	1.4
Current tobacco smoking	1.5	2.5	10.6	0.8	-1.5	-3.3	0.9	-0.2	-0.9
Mouth/teeth dental problems	1.5	2.2	7.4	-1.6	-0.6	-1.5	-0.3	-0.8	-2.7
Father’s age at death	1.5	2.1	5.6	0.2	-1.1	-2.4	-0.4	-0.9	-2.1
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	7.7	-0.6	0.0	-1.0	-1.0	2.8	1.2
Illnesses of mother	1.5	1.9	6.1	1.0	1.7	1.1	2.5	0.0	-0.1
Breastfed as a baby	1.5	1.9	6.7	-2.6	-1.6	-1.2	-0.6	0.2	-0.5
Angina (self-reported)	1.5	1.9	5.5	2.4	-0.1	1.3	-0.6	-0.2	1.9
Loneliness, isolation	1.5	2.1	8.2	2.9	0.4	-0.3	0.9	0.5	1.8
Hearing aid user	1.5	1.7	4.3	-0.6	-0.0	-1.9	2.1	1.2	-0.6
Medication: Paracetamol	1.5	2.3	7.1	-0.7	-0.3	-2.4	-0.7	2.7	-0.2
Average weekly beer plus cider intake	1.5	2.2	5.2	0.2	0.2	-2.0	1.9	2.3	0.5
Medication: Co-codamol	1.4	1.6	3.2	1.8	1.3	-0.2	-0.7	1.7	1.2
Severe depression (siblings)	1.4	1.6	2.9	-1.6	-1.5	-1.3	0.4	0.2	-1.7
Illnesses of siblings	1.4	2.0	3.2	-1.7	-1.1	-1.8	0.4	1.8	-1.2
Trunk fat-free mass	1.4	8.0	14.7	3.6	1.4	3.8	0.4	-2.4	3.6
Trunk predicted mass	1.4	7.7	14.1	3.5	1.3	3.8	0.3	-2.4	3.6
Age at first live birth	1.4	2.5	6.4	-2.5	-1.2	-1.4	-1.1	0.2	-2.0
Commuting to job workplace: Car/motor vehicle	1.4	1.5	4.0	-0.7	1.2	-0.1	-1.6	-0.9	-2.0
Handedness (chirality/laterality): Left-handed	1.4	1.6	3.6	1.9	-1.5	1.5	0.0	-0.0	1.3
Breast cancer (self-reported)	1.4	1.7	3.8	-0.0	1.9	1.8	0.5	-0.5	1.5
Medication: Metformin	1.3	1.8	4.7	-1.1	-0.4	-2.0	0.4	-0.7	-2.2
Leg fat-free mass (left)	1.3	7.0	12.2	3.5	1.8	3.2	0.6	-1.9	3.5
Leg predicted mass (left)	1.3	6.9	11.8	3.4	1.8	3.2	0.7	-2.0	3.4
Hair/balding pattern: Pattern 2	1.3	1.7	6.0	2.5	1.1	1.1	0.3	-0.4	1.1
Impedance of arm (right)	1.3	6.0	13.7	2.6	3.7	2.6	-0.6	-0.5	2.8
Medication: Paracetamol	1.3	2.2	6.4	-0.9	-0.9	-2.2	-0.2	2.5	-0.3
Chronic bronchitis/emphysema (mother)	1.3	1.5	3.0	-1.5	-0.4	-1.1	-1.5	1.7	-0.6
Whole body fat-free mass	1.3	7.7	13.0	3.6	1.5	3.6	0.3	-2.2	3.6
Leg predicted mass (right)	1.3	6.9	13.6	3.4	1.5	3.2	0.3	-1.8	3.7
Medication: Atorvastatin	1.3	1.6	4.9	2.2	-0.4	1.4	1.6	0.4	0.2
Heart attack/myocardial infarction (self-reported)	1.3	1.7	5.1	2.2	-0.4	0.5	0.1	0.0	2.2
Qualifications: CSEs or equivalent	1.2	1.6	3.7	1.0	0.6	1.9	1.9	-0.1	1.0
High blood pressure (mother)	1.2	1.7	4.7	-0.6	-1.7	-2.2	-1.2	0.7	-0.2
Worry too long after embarrassment	1.2	2.0	4.2	1.0	2.0	-1.0	1.9	1.0	0.9
Medication: Omeprazole	1.2	1.5	3.9	1.9	0.4	-0.3	0.9	0.5	2.0
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	2.7	-1.7	-1.3	-1.0	-0.7	1.4	-0.7
Illnesses of father: Heart disease	1.2	1.6	3.7	1.4	-1.0	1.0	-0.7	1.1	1.9
Illnesses of siblings: Diabetes	1.2	1.5	3.1	-1.0	-1.1	-1.2	-1.0	-1.8	-1.2
Leg fat-free mass (right)	1.2	6.7	13.3	3.4	1.5	3.1	0.3	-1.8	3.7
Ever had bowel cancer screening	1.2	1.4	3.4	-0.6	-1.9	1.1	-0.9	0.2	1.5
Mouth/teeth dental problems: Mouth ulcers	1.2	1.8	4.5	1.2	0.3	2.1	1.0	-0.3	2.0
Smoking status: Current	1.2	1.9	8.2	0.8	-1.2	-2.9	0.9	-0.3	-0.8
Whole body water mass	1.2	6.7	11.5	3.3	1.3	3.4	0.3	-2.2	3.3
Ever taken oral contraceptive pill	1.2	1.4	2.7	1.6	1.6	0.3	1.5	-0.2	0.8
Basal metabolic rate	1.2	6.7	11.6	3.2	1.6	3.4	0.0	-2.4	3.2
Schizophrenia (2018)	1.1	2.2	6.2	0.2	0.4	0.5	0.8	2.5	2.5
Alzheimer’s Disease (in father)	1.1	1.2	3.6	0.8	1.9	-0.3	1.7	-0.4	-0.3
Lupus	1.1	1.6	4.1	-1.3	1.4	-2.0	-0.7	0.0	-1.2
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.9	1.5	0.0	0.6	-2.0	0.3	1.4
Maternal smoking around birth	1.1	1.6	5.5	0.6	0.5	0.4	-2.4	0.9	1.7
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	3.3	1.8	0.9	0.3	-1.2	-1.1	0.8
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.6	6.9	-2.6	-0.1	-0.3	0.3	2.2	-1.9
Medication: Ramipril	1.1	1.4	3.5	-1.3	-0.3	-0.8	-1.9	-0.6	-1.5
Pulse rate, automated reading	1.1	3.4	7.6	-2.5	-0.6	-2.3	0.6	0.9	-2.8
Family relationship satisfaction	1.1	1.4	4.2	1.7	2.0	0.4	-0.3	0.0	1.0
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	3.3	0.5	-0.4	-1.4	0.2	-1.6	-1.8
Type 2 Diabetes (T2D) (2018)	1.0	1.8	5.1	-1.6	0.5	-1.7	-0.2	-0.4	-2.2
Average weekly spirits intake	1.0	1.2	6.4	0.5	-2.5	-0.2	-0.5	0.4	-0.1
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.9	1.7	0.7	0.8	0.2	0.9	1.3
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.9	-1.2	-0.1	-0.1	-0.5	-1.7	-1.7
Medication: Levothyroxine sodium	1.0	1.7	4.6	2.1	-0.9	1.2	-1.5	-0.6	0.8
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	7.3	2.7	-0.5	0.1	1.0	-0.3	0.6
Hearing difficulty/problems with background noise	1.0	1.6	5.5	-1.6	-0.0	-1.3	-0.4	2.3	-0.2
Medication: Lansoprazole	1.0	1.1	2.2	-1.3	0.8	-1.1	1.5	0.7	-0.7
Blood clot in the leg (DVT)	1.0	1.3	3.8	0.2	-0.3	-1.2	-0.3	-1.5	-1.9
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	4.1	1.4	-0.7	2.0	-1.6	-1.0	1.0
Medication for pain relief, constipation, heartburn	1.0	1.7	3.6	0.3	1.5	1.3	1.2	-1.9	-0.9
Friendships satisfaction	1.0	1.3	3.6	1.2	1.9	1.1	-0.3	-0.4	1.0
Age started oral contraceptive pill	1.0	1.3	3.9	0.4	0.2	1.2	-2.0	-1.3	-0.4
Diastolic blood pressure, automated reading	1.0	3.1	9.5	-3.1	-0.9	-1.7	0.1	1.1	-2.1
Mean Putamen Volume	0.9	1.0	4.4	0.3	0.8	0.6	-2.1	-0.6	0.4
HDL Cholesterol	0.9	1.5	6.4	-0.6	-2.5	-1.3	-0.6	0.0	-0.5
Type 2 Diabetes (T2D) (2012)	0.9	1.0	4.0	-1.1	-0.6	-2.0	0.6	0.0	-0.6
Frequency of depressed mood in last 2 weeks	0.9	1.2	3.8	1.9	-0.4	-0.5	0.3	1.0	1.4
Hearing difficulty/problems: Yes	0.9	1.3	4.6	-0.9	-0.6	0.6	0.8	2.1	1.1
Fed-up feelings	0.9	1.6	4.6	1.9	0.1	-0.4	-1.0	0.3	2.1
Supplements: Glucosamine	0.9	1.1	3.1	-0.6	-0.1	-0.6	1.6	0.6	-1.8
Medication: Atenolol	0.9	1.1	2.4	1.6	0.3	1.2	-0.1	-1.3	1.1
Qualifications: None of the above	0.9	1.9	4.1	1.4	1.3	1.3	-1.3	-2.0	0.4
Hip circumference	0.9	3.7	7.0	2.6	1.0	2.3	-1.2	-1.4	2.4
Birth weight of first child	0.9	1.6	4.1	1.5	-0.2	0.7	-0.4	1.5	2.0
Ever highly irritable/argumentative for 2 days	0.9	1.1	4.5	-0.4	0.2	-0.7	0.0	-1.1	-2.1
Forced vital capacity (FVC), Best measure	0.9	3.4	6.7	1.9	2.2	2.1	0.6	-0.4	2.6
Crohns Disease (2017)	0.8	1.7	2.9	1.6	1.7	-0.2	0.5	-1.5	-1.4
Neuroticism (2016)	0.8	1.1	3.9	2.0	1.2	-0.8	0.1	-0.3	0.9
Neuroticism	0.8	2.0	6.8	2.6	-0.1	-0.8	1.9	0.8	0.8
Number of treatments/medications taken	0.8	1.5	3.5	-0.1	-0.8	-1.6	-1.9	1.4	-0.3
Medication for hormone replacement therapy	0.8	0.9	2.7	0.5	1.6	-1.3	0.4	-0.5	-0.7
Townsend deprivation index at recruitment	0.8	1.1	2.5	1.2	0.2	0.2	1.6	-1.5	0.1
Age when periods started (menarche)	0.8	1.8	4.2	-1.2	1.6	0.0	-0.7	-2.0	-1.4
Had other major operations	0.8	1.0	2.5	1.6	0.7	0.8	-0.3	-0.9	1.1
Forced vital capacity (FVC)	0.8	3.0	8.2	1.2	1.8	2.3	-0.1	-0.1	2.9
Neuroticism score	0.8	1.7	6.7	2.6	0.4	-0.9	1.0	0.3	1.2
Weight	0.8	3.9	7.0	2.2	1.7	2.6	-0.7	-2.0	2.1
Falls in the last year	0.8	1.1	2.3	-0.8	0.8	-1.4	1.5	0.8	-0.6
Pulse rate	0.8	1.4	4.8	-1.2	0.3	-1.3	0.6	-0.1	-2.2
Depression (self-reported)	0.8	0.9	2.2	1.5	-1.5	0.3	0.9	0.2	0.4
Impedance of arm (left)	0.8	3.5	8.2	1.5	2.9	2.0	-0.8	-0.4	2.4
Medication: Ventolin 100micrograms inhaler	0.8	1.1	2.9	-0.7	1.7	-0.8	1.0	1.0	0.7
Mean time to correctly identify matches	0.8	1.5	4.5	0.4	-0.1	-0.7	-0.4	1.9	2.1
Age at last live birth	0.8	1.2	2.5	-1.6	-1.2	-1.2	-0.5	1.3	0.1
Average weekly red wine intake	0.8	1.1	3.7	-0.8	-0.6	1.9	-1.3	0.3	0.6
Mineral and other dietary supplements	0.8	1.1	4.4	0.3	1.1	0.2	-1.0	-2.1	-0.1
Osteoporosis (self-reported)	0.8	1.0	3.2	-0.3	-0.2	-0.7	-1.8	1.4	0.2
Illnesses of father: None of the above (group 1)	0.8	1.0	2.6	-1.2	-0.2	-1.0	-0.1	-0.8	-1.6
Miserableness	0.8	1.4	3.8	0.9	1.4	-0.7	0.1	-2.0	-1.1
Guilty feelings	0.8	1.2	3.6	1.5	0.7	0.2	0.7	0.7	1.9
Wears glasses or contact lenses	0.8	0.9	2.4	0.8	0.5	-0.2	0.9	1.2	1.6
Commuting to job workplace: Public transport	0.8	0.9	1.7	-1.3	-0.5	-0.9	0.9	0.7	1.2
Pain type(s) experienced in last month: Hip pain	0.8	1.0	4.0	0.1	2.0	0.5	-1.1	-0.6	0.0
Medication: Lisinopril	0.8	1.0	1.6	0.0	-1.2	-1.0	-0.9	1.2	1.1
Arm fat-free mass (left)	0.8	3.8	7.4	2.3	0.6	2.7	-0.5	-2.4	2.1
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.5	1.2	0.5	-0.4	0.6	1.1	1.6
Neuroticism (Nagel 2018)	0.7	1.7	4.6	1.6	2.1	-0.2	1.1	0.3	1.3
Reaction Time	0.7	1.3	3.6	-0.2	0.0	-0.8	-0.5	1.8	1.9
Ovarian Cancer	0.7	1.0	3.1	-0.1	1.2	-0.1	0.2	1.8	1.1
Triglycerides	0.7	1.2	4.4	-1.1	0.1	-2.1	-1.1	0.0	-0.6
Vitamin and mineral supplements	0.7	0.9	2.0	0.7	1.1	-0.9	-1.0	-1.4	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.6	1.6	-1.2	-1.0	-0.2	0.4	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	4.3	-2.1	0.7	-0.2	0.1	1.4	-1.4
Hayfever, allergic rhinitis or eczema	0.7	1.6	6.0	1.5	0.7	2.5	-0.4	-0.8	0.2
Allergy	0.7	1.7	4.6	-1.5	-0.8	-2.1	-0.8	1.5	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.7	1.8	1.4	-0.1	0.6	-0.0	0.8	1.3
Pulse wave reflection index	0.7	0.9	3.0	0.4	-0.2	-1.3	1.7	0.7	-0.4
Medication: Amlodipine	0.7	0.9	2.2	0.5	-0.2	-1.5	1.4	0.3	-0.9
Health satisfaction	0.7	0.9	2.5	0.7	1.6	1.0	0.2	0.0	1.1
Qualifications: College or University degree	0.7	2.3	4.4	-1.1	-0.9	-2.1	1.8	1.7	-1.3
Leg pain on walking	0.7	0.8	2.4	0.5	0.8	1.1	-0.5	-1.5	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.2	1.5	0.9	0.8	-0.5	0.1	0.8
Eye problems/disorders: Cataract	0.7	0.8	1.8	-0.2	0.4	-0.5	-1.0	-1.3	-1.3
Osteoarthritis (self-reported)	0.7	0.9	3.6	0.1	1.0	0.5	-0.6	-1.9	-0.4
Irritability	0.7	1.2	3.2	1.8	0.9	0.7	0.4	0.1	1.6
Fractured/broken bones in last 5 years	0.7	0.9	3.2	1.8	1.0	0.5	0.2	0.2	0.9
Arm predicted mass (left)	0.7	3.5	6.5	2.1	0.4	2.5	-0.6	-2.5	1.8
Bipolar Disorder or Schizophrenia	0.6	1.4	7.5	-0.2	-0.1	0.3	0.8	0.0	2.7
Alzheimer’s Disease (in mother)	0.6	0.7	2.9	-0.4	-1.7	-0.5	0.6	-0.9	0.3
Crohns Disease (2012)	0.6	1.0	3.3	0.7	1.4	-0.5	0.4	0.0	-1.8
Rheumatoid Arthritis	0.6	0.8	2.1	1.2	-1.1	0.0	-0.4	-0.2	1.4
Blood White Count	0.6	4.4	12.5	0.1	1.6	-1.3	0.3	-3.1	-3.5
Systolic Blood Pressure	0.6	2.8	10.0	0.9	0.0	1.8	-1.4	-3.2	-1.1
Allergy or Eczema	0.6	1.7	5.0	1.3	0.9	2.2	-1.2	-0.3	1.1
Respiratory disease	0.6	1.3	4.4	-0.5	-0.7	0.4	0.1	1.6	2.1
Systolic blood pressure, automated reading	0.6	1.8	4.6	-0.0	0.7	2.2	-0.9	-2.1	-0.3
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	2.2	0.2	-0.9	-1.1	0.0	0.1	-1.5
Diabetes (mother)	0.6	0.7	1.6	1.3	1.3	0.4	0.4	0.7	0.6
Hand grip strength (right)	0.6	1.7	5.3	-1.4	-1.3	-0.9	-0.3	-0.8	-2.3
Trunk fat mass	0.6	2.6	4.3	1.5	2.1	1.7	-1.1	-1.6	1.5
Nervous feelings	0.6	1.1	4.8	0.7	1.0	-0.7	2.2	0.2	-0.2
Diabetes (self-reported)	0.6	0.9	2.5	-1.3	0.0	-1.6	-0.2	-0.3	-1.2
Worrier / anxious feelings	0.6	1.1	2.6	0.8	-0.9	-0.8	1.6	1.1	0.8
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	5.5	1.3	1.3	1.6	0.3	0.7	2.4
Noisy workplace	0.6	0.8	2.3	0.4	1.5	-1.1	-0.9	0.2	0.4
Qualifications: A levels/AS levels or equivalent	0.6	1.4	6.4	-0.4	-0.3	-0.1	0.0	2.5	1.3
Prospective memory result	0.6	0.8	2.2	-0.8	-0.7	-0.9	0.6	1.5	0.3
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.2	-1.1	-1.5	0.4	-0.9	1.1	0.5
Arm fat-free mass (right)	0.6	3.0	6.3	1.7	0.1	2.5	-0.4	-2.2	1.9
Emphysema/chronic bronchitis	0.6	0.7	4.1	-0.1	0.2	0.1	-0.4	-2.0	-0.1
Arm predicted mass (right)	0.6	3.0	6.0	1.8	0.1	2.5	-0.4	-2.3	1.7
Smoking status: Previous	0.6	0.9	3.5	-0.2	-0.5	1.9	-0.2	-1.2	-0.2
Long-standing illness, disability or infirmity	0.6	1.0	2.4	1.3	0.1	0.4	1.6	0.9	0.8
Qualifications: nursing, teaching	0.6	0.9	2.5	-0.4	-0.9	-0.7	1.3	1.6	-0.2
Illnesses of father: High blood pressure	0.6	0.8	1.9	-1.4	1.4	-0.3	0.3	0.7	-0.4
Ever smoked	0.6	1.0	1.6	-1.3	-1.2	-1.2	0.3	0.6	-1.0
Number of operations (self-reported)	0.6	1.0	1.8	0.5	1.1	1.2	-1.3	-0.9	0.6
Basal cell carcinoma (self-reported)	0.6	0.7	2.5	-1.6	-0.5	1.1	0.1	-0.5	0.1
Depression (Nagel 2018)	0.5	0.7	1.5	1.2	-1.0	-1.1	0.9	0.3	0.0
Schizophrenia (2014)	0.5	1.1	6.2	-0.0	-0.1	0.3	0.6	0.0	2.5
Cardiovascular Disease	0.5	1.8	4.9	-0.1	1.3	0.5	0.2	-2.2	-2.0
Hypothyroidism (self reported)	0.5	1.1	2.6	1.1	-0.1	1.6	-1.1	-1.1	0.3
Chronotype (morning person)	0.5	1.1	2.1	-1.2	0.2	1.5	1.3	-1.1	-0.2
Hand grip strength (left)	0.5	1.3	5.2	-0.9	-0.6	-1.2	0.0	-0.3	-2.3
Diabetes (father)	0.5	0.6	2.8	1.7	-0.4	-0.5	0.6	0.1	-0.1
Average weekly fortified wine intake	0.5	0.6	1.1	-0.9	-0.9	1.0	0.3	-0.3	-1.0
Stomach or abdominal pain in last month	0.5	0.7	3.2	-0.5	1.8	0.0	-0.6	-0.5	-0.1
Alcohol usually taken with meals	0.5	0.9	1.8	-0.7	-1.3	1.0	-1.3	-0.3	0.5
Pain all over the body in last month	0.5	0.6	1.6	1.3	0.8	0.1	-0.8	-0.7	-0.0
Medication: Cholesterol lowering	0.5	0.8	3.6	0.9	0.2	-0.6	1.9	-0.1	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	3.2	1.4	1.8	1.3	0.6	0.2	1.8
Tense / ‘highly strung’	0.5	0.8	2.9	1.7	-0.7	-0.4	0.3	0.3	1.1
Loud music exposure frequency	0.5	0.6	1.8	0.3	1.3	-0.6	-0.7	-0.7	0.4
Number of full brothers	0.5	0.6	2.2	-0.1	0.5	0.6	-1.5	-1.0	0.0
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.9	-1.4	-0.4	-0.8	-0.1	0.1	-0.9
Medication: Allopurinol	0.5	0.6	1.7	-0.2	0.3	-1.3	1.0	0.8	-0.7
Chest pain or discomfort	0.5	0.8	1.8	-0.9	-1.2	-0.2	-0.6	0.0	-1.3
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.2	-1.1	-1.1	-0.4	-0.2	0.9	-0.4
Risk taking	0.5	0.8	1.6	-0.2	0.1	1.1	1.3	1.1	0.6
Ever had prostate specific antigen (PSA) test	0.5	0.5	0.8	0.9	-0.6	-0.7	0.6	0.5	0.9
Commuting to job workplace: Cycle	0.5	0.6	1.8	-0.3	-0.1	-1.0	-0.5	-1.4	-0.5
Supplements: Calcium	0.5	0.5	1.4	1.2	-0.1	0.8	0.6	-0.7	-0.6
Pack years of smoking	0.5	0.8	2.2	0.3	1.4	0.2	-1.5	-0.2	0.7
Alzheimer’s Disease (including proxy)	0.4	0.5	2.0	-0.2	-0.2	-0.9	1.4	-0.3	0.4
Irritable Bowel Disease (IBD)	0.4	1.0	2.5	1.6	1.1	-0.3	0.3	-0.6	-1.3
Major Depression (MDD)	0.4	0.5	2.0	1.4	-0.2	0.7	0.4	0.1	0.7
Age at First Birth	0.4	0.5	1.6	-1.3	-0.5	-0.0	1.1	0.4	-0.1
Body Mass Index (BMI) (2010)	0.4	0.6	1.5	1.0	0.7	0.5	-1.2	0.0	0.5
Primary Biliary Cirrhosis	0.4	0.5	1.3	-1.1	-1.1	-0.4	-0.6	0.4	-0.1
Ulcerative Colitis	0.4	0.6	2.7	0.5	-0.5	0.6	1.6	0.0	-0.3
Blood Eosinophil Count	0.4	3.4	14.1	1.8	3.8	1.6	-0.2	-0.3	0.7
Blood Red Count	0.4	4.1	12.2	3.1	1.3	1.1	3.5	0.4	0.2
Smoking Status	0.4	1.1	1.5	0.7	-0.7	-1.2	1.2	-0.9	-1.2
Supplements: Zinc	0.4	0.4	0.8	0.2	-0.9	0.3	-0.7	0.7	0.8
Pack years adult smoking proportion	0.4	0.6	1.7	0.1	1.3	0.1	-1.2	-0.2	0.3
Impedance of leg (right)	0.4	2.1	4.6	0.1	1.7	1.4	-1.5	-2.1	-1.0
Trunk fat percentage	0.4	1.6	3.3	0.9	1.8	1.1	-1.4	-1.3	0.9
Taking other prescription medications	0.4	0.7	2.7	1.6	-0.5	0.3	-0.5	0.4	0.8
Multivitamins +/- minerals	0.4	0.6	1.4	-0.9	-1.2	0.8	-0.2	0.7	0.1
Chronic bronchitis/emphysema (father)	0.4	0.4	1.2	-1.0	0.3	-0.2	-1.1	-0.0	-0.4
Impedance of leg (left)	0.4	1.8	4.8	-0.2	1.1	1.1	-2.2	-1.6	-1.0
Waist circumference	0.4	1.6	3.7	1.6	0.9	1.4	-0.5	-0.4	1.9
Time employed in main current job	0.4	0.5	0.7	-0.7	0.3	-0.6	0.8	-0.7	-0.8
Alcohol intake versus 10 years previously	0.4	0.6	2.4	-0.2	1.6	-0.8	-0.3	0.2	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	4.1	2.0	-0.2	0.1	0.2	-0.4	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	3.0	1.7	-0.5	0.3	0.6	-0.4	-0.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.8	-0.2	-0.7	-0.4	-0.8	1.4	0.6
Leg fat percentage (right)	0.4	1.6	4.0	-1.4	0.5	-0.5	-1.2	-1.3	-2.0
Exposure to tobacco smoke outside home	0.4	0.6	2.0	1.4	-0.2	-0.7	0.4	0.4	-0.7
Comparative body size at age 10	0.4	1.2	3.0	-0.6	1.7	-0.1	1.3	-0.6	-1.4
Wheeze or whistling in the chest in last year	0.4	0.8	1.7	-0.4	-0.3	1.2	-0.8	-1.3	-0.7
Number of children fathered	0.4	0.5	0.8	-0.8	-0.5	0.8	-0.9	-0.7	-0.5
Pulse wave peak to peak time	0.4	0.5	1.1	-0.5	-0.4	1.0	-0.6	-0.3	0.9
Neck or shoulder pain in last month	0.4	0.5	1.2	1.1	-1.0	0.8	-0.2	0.2	0.4
Medication: Seretide 50 evohaler	0.4	0.5	1.4	-0.6	0.6	0.3	1.2	0.8	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.0	-1.0	-0.6	-0.4	-0.4	-0.7	-1.0
Number of full sisters	0.4	0.5	1.1	0.6	1.1	-1.0	0.6	0.2	0.6
Medication: Aspirin	0.4	0.6	1.4	0.1	-0.5	1.2	-1.2	-0.3	0.5
Medication: Aspirin	0.4	0.5	2.2	-0.1	-0.7	0.6	-1.5	-0.1	0.5
Mother’s age at death	0.4	0.5	1.2	-1.1	-0.1	0.3	1.0	0.3	-0.8
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.1	-0.6	0.2	-1.1	-0.3	-0.9	-0.3
Medication: Bendroflumethiazide	0.4	0.6	2.2	0.6	0.4	1.5	-0.1	0.4	0.9
Leg fat percentage (left)	0.4	1.5	3.6	-1.4	0.2	-0.7	-1.5	-0.9	-1.9
Pain experienced in last month	0.4	0.6	1.6	-0.6	-1.3	-0.4	-0.6	-0.8	-0.7
Impedance of whole body	0.4	2.0	5.4	0.6	2.3	1.7	-1.4	-1.1	0.7
Depressed Affect (Nagel 2018)	0.3	0.7	2.3	1.5	1.2	-0.5	0.5	-0.2	0.2
Worry (Nagel 2018)	0.3	0.6	1.3	0.7	0.5	-0.9	1.1	0.7	0.5
Fasting Glucose	0.3	0.4	1.2	-0.7	0.2	-0.0	1.1	0.6	-0.0
Relative age voice broke	0.3	0.5	1.1	-0.7	0.5	-0.9	-0.2	0.6	-1.0
Serious illness, injury or assault to yourself	0.3	0.4	1.0	0.4	0.5	-0.1	0.5	0.7	1.0
High blood pressure	0.3	0.7	1.4	-1.1	0.8	-0.7	0.3	-0.7	-1.2
Had menopause	0.3	0.4	1.0	-0.8	-0.3	-0.2	-1.0	-0.5	-0.7
Pulse wave Arterial Stiffness index	0.3	0.4	1.2	1.1	0.9	-0.4	0.5	0.1	-0.2
Gout (self-reported)	0.3	0.4	1.6	0.2	0.7	-0.3	1.2	0.2	0.1
High blood pressure (siblings)	0.3	0.5	1.0	0.3	1.0	0.7	-0.6	-0.8	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.0	0.2	0.7	0.6	0.4	0.5	1.0
Shortness of breath walking on level ground	0.3	0.3	1.5	-0.2	0.2	0.3	-0.1	-1.2	-0.3
Eye problems/disorders: None of the above	0.3	0.4	1.4	-0.5	0.3	0.7	0.2	-1.2	-0.1
Medication: Blood pressure	0.3	0.5	1.3	0.2	1.1	-0.7	-0.3	-1.0	-0.6
Whole body fat mass	0.3	1.3	1.9	0.9	1.3	1.0	-1.1	-1.4	0.9
Alcohol intake frequency.	0.3	0.8	4.2	0.3	0.2	-2.0	-0.5	0.2	0.3
Suffer from ‘nerves’	0.3	0.4	1.3	0.5	0.0	-1.1	0.6	-0.8	0.0
Overall health rating	0.3	0.7	2.5	1.6	0.4	-0.4	-0.7	-0.0	1.0
Had major operations	0.3	0.4	0.9	0.2	-0.3	0.9	0.8	-0.8	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.7	0.8	-0.4	-0.4	0.5	0.6	0.4
Diabetes diagnosed by doctor	0.3	0.5	1.9	-0.6	0.1	-0.9	0.2	-0.5	-1.4
Commuting to job workplace: Walk	0.3	0.3	0.7	0.7	0.7	0.8	-0.2	-0.6	-0.0
Medication: Gliclazide	0.3	0.4	1.3	0.1	-0.5	-0.7	1.1	-0.2	-0.3
Medication: Blood pressure	0.3	0.6	2.2	-0.5	-1.5	0.8	-0.3	0.1	0.4
Bipolar Disorder (2018)	0.2	0.3	1.5	-0.5	0.1	-0.2	0.2	0.0	1.2
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	0.5	0.4	0.7	0.8	0.0	0.1
Ulcerative Colitis (UC)	0.2	0.4	1.3	0.1	-0.4	-0.5	0.7	0.5	-1.2
BMI	0.2	1.2	3.1	-1.4	-0.2	-0.3	-0.8	-1.2	-1.8
Waist Hip Ratio (WHR)	0.2	0.8	1.6	-0.3	0.9	1.3	1.0	0.2	1.1
Lung FVC	0.2	1.3	4.4	-1.3	0.2	-0.8	2.1	0.6	-0.6
Hair Pigment	0.2	5.7	17.4	2.9	0.4	2.7	-1.0	-4.2	0.3
Relative age of first facial hair	0.2	0.4	1.5	0.5	-0.4	-1.2	-0.0	0.0	-0.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.4	0.6	0.0	0.5	-0.5	-0.6	0.1
Number of incorrect matches in round	0.2	0.3	0.7	0.0	-0.1	0.7	0.8	-0.8	0.5
Past tobacco smoking	0.2	0.3	0.9	0.3	0.9	-0.6	0.4	0.6	0.0
Medication: Simvastatin	0.2	0.3	1.1	-0.3	-0.3	-1.0	-0.2	0.5	-0.2
Fluid intelligence score	0.2	0.4	1.0	-1.0	-0.1	0.3	0.5	0.5	-1.0
Asthma	0.2	0.4	1.5	-0.6	-0.3	-0.4	1.2	-0.0	-0.2
Lung cancer (father)	0.2	0.2	1.2	0.0	0.4	1.1	-0.1	-0.1	0.4
Arm fat mass (right)	0.2	0.6	0.8	0.9	0.9	0.7	-0.7	-0.8	0.8
Exposure to tobacco smoke at home	0.2	0.2	0.5	0.0	-0.7	0.3	0.6	0.5	0.6
Body fat percentage	0.2	0.8	1.9	-0.3	1.2	0.1	-1.4	-1.0	-0.3
Leg fat mass (right)	0.2	0.8	2.2	0.2	1.0	0.6	-1.0	-1.5	-0.3
Knee pain experienced in last month	0.2	0.2	0.9	-0.3	0.3	0.9	0.2	0.4	0.5
Hypertension (Self-reported)	0.2	0.6	1.5	-1.0	0.9	-0.5	-0.0	-0.6	-1.2
Mood swings	0.2	0.3	0.8	0.9	0.5	-0.4	-0.4	-0.5	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.5	-0.4	-0.8	-1.2	0.2	0.9	-0.3
Number of self-reported non-cancer illnesses	0.2	0.4	1.3	1.1	0.3	-0.2	0.6	-0.7	0.3
Financial situation satisfaction	0.2	0.3	0.9	0.3	0.3	1.0	0.3	0.2	0.7
High cholesterol (Self-reported)	0.2	0.3	1.0	0.4	0.1	-0.7	0.3	-0.2	-1.0
Ever depressed for a whole week	0.2	0.2	0.7	-0.1	-0.1	0.5	-0.9	-0.6	-0.2
Unable to work because of sickness or disability	0.2	0.3	1.4	-0.0	0.3	0.5	1.2	-0.3	-0.1
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.8	-0.3	-1.3	-0.4	-0.6	0.6	-0.1
Cholesterol lowering medication	0.2	0.3	0.7	0.3	-0.2	0.7	-0.2	0.8	0.4
Alcohol drinker status: Previous	0.2	0.3	0.8	-0.3	-0.6	-0.9	-0.4	0.2	-0.5
Leg fat mass (left)	0.2	0.6	1.6	0.1	0.6	0.4	-1.1	-1.3	-0.4
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.8	-0.8	-0.3	-0.7	0.2	0.9	0.0
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.7	-0.8	0.2	0.2	-0.0	0.7	0.1
Breast Cancer	0.1	0.2	0.6	0.2	-0.3	-0.5	0.4	0.4	-0.8
LDL Cholesterol	0.1	0.2	0.9	0.1	-0.5	-0.9	0.5	0.0	-0.1
Blood Platelet Count	0.1	1.0	2.4	0.5	1.6	0.3	1.2	-0.1	-1.3
Lung FEV1/FVC ratio	0.1	0.4	0.9	0.3	-0.5	-0.6	0.9	0.9	0.3
Tanning	0.1	1.8	5.1	0.9	1.0	1.8	2.3	-0.7	0.4
Body mass index (BMI)	0.1	0.4	0.8	-0.8	-0.5	-0.9	-0.5	-0.0	-0.9
Financial difficulties in last 2 years	0.1	0.2	0.4	0.2	0.4	-0.6	0.3	0.4	0.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.5	0.2	-0.0	-0.5	0.2	0.1	0.7
Arm fat percentage (right)	0.1	0.2	0.8	0.0	0.9	-0.2	-0.8	-0.0	0.1
Mouth/teeth dental problems: Dentures	0.1	0.2	0.6	0.2	0.3	0.0	-0.6	-0.1	0.7
Length of working week for main job	0.1	0.1	0.6	0.2	0.8	-0.1	0.4	-0.3	-0.0
Peak expiratory flow (PEF)	0.1	0.2	1.1	-0.2	0.2	0.4	-0.2	1.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.3	-0.3	-0.3	0.0	-0.5	-0.6	0.6
Arm fat percentage (left)	0.1	0.2	0.6	-0.6	0.5	-0.4	-0.8	-0.0	-0.1
Back pain experienced in last month	0.1	0.2	0.5	0.4	0.5	-0.1	-0.6	0.7	0.1
Asthma (self-reported)	0.1	0.2	1.0	-0.1	-0.2	-0.3	1.0	-0.2	-0.1
Arm fat mass (left)	0.1	0.4	0.8	0.5	0.5	0.6	-0.7	-0.9	0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Medication for cholesterol	0.0	0.1	0.1	0.3	0.2	-0.3	0.3	-0.4	0.0

Hub : Genes

TMEM91

Models

Trait associations