TWAS hub - B9D2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.1344	0.0417	2.9e-04	0.079	NA	0.058	NA	0.063	3.0e-06	NA	6.5e-05	NA	2.9e-05
2	GTEx	Testis	0.1840	0.0690	4.3e-03	0.211	NA	0.171	NA	0.190	9.9e-10	NA	5.0e-08	NA	7.9e-09
3	YFS	Blood	0.0302	0.0123	3.1e-04	0.016	0.013	0.019	0.018	0.017	3.6e-06	3.6e-05	5.6e-07	1.3e-06	2.1e-06
4	TCGA	Breast Invasive Carcinoma	0.0160	0.0110	4.5e-03	0.000	0.004	0.006	NA	-0.001	3.2e-01	3.8e-02	1.9e-02	NA	5.3e-01
5	TCGA	Colon Adenocarcinoma	0.0850	0.0440	8.8e-05	0.054	0.076	0.066	NA	0.049	4.7e-04	3.4e-05	1.2e-04	NA	7.8e-04
6	TCGA	Brain Lower Grade Glioma	0.0729	0.0313	1.1e-06	0.043	0.051	0.036	NA	0.050	1.1e-05	1.8e-06	5.1e-05	NA	2.1e-06
7	TCGA	Lung Squamous Cell Carcinoma	0.0586	0.0276	5.5e-04	0.039	0.025	0.027	NA	0.031	2.4e-05	6.8e-04	4.1e-04	NA	1.9e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Hair/balding pattern: Pattern 4	9.6	23.2	41.7	-6.5	-4.0	-5.1	-4.3	-5.9	-3.2	-3.9
Medication: Metformin	6.9	9.8	19.0	-3.1	-3.4	-4.0	-0.9	-1.0	-4.4	-3.3
Hair/balding pattern: Pattern 3	6.7	10.0	21.1	-3.8	-2.5	-1.7	-3.5	-4.6	-1.8	-3.1
Migraine (self-reported)	6.4	7.9	13.2	-3.0	-3.6	-2.3	-1.2	-1.9	-3.1	-3.6
Heart disease (siblings)	6.2	7.6	9.6	2.8	2.8	2.6	3.1	2.6	2.7	2.6
Headache pain in last month	5.9	10.1	16.4	-4.0	-3.2	-2.2	-3.0	-3.3	-2.5	-3.6
Height	4.8	91.6	176.9	13.3	7.2	11.1	7.9	9.7	8.6	7.8
Comparative height size at age 10	4.7	26.0	50.9	7.1	3.5	6.1	4.4	5.0	4.4	4.3
Eye problems/disorders: Diabetes related eye disease	3.7	4.1	9.0	-2.1	-2.0	-3.0	-0.7	-0.3	-2.6	-2.1
Standing height	3.6	36.2	73.1	8.6	3.9	7.4	5.2	6.3	4.9	4.5
Illnesses of siblings	3.3	4.7	6.3	-2.4	-2.2	-2.1	-2.2	-2.5	-1.4	-2.2
Medication: Paracetamol	3.3	5.4	13.4	-2.5	-1.7	-1.7	-3.7	-2.7	-1.2	-2.0
Osteoarthritis (self-reported)	3.3	4.2	6.8	2.0	2.6	0.7	2.6	1.9	1.6	2.4
Coronary Artery Disease (CAD)	3.2	3.9	22.3	2.0	0.0	-0.2	0.0	4.7	0.1	0.9
Type 2 Diabetes (T2D) (2018)	3.0	5.7	12.0	-2.5	-2.3	-2.9	-1.1	-0.9	-3.5	-2.4
Pulse wave reflection index	2.8	3.4	5.0	-2.2	-2.0	-2.0	-1.1	-1.1	-2.1	-2.1
Medication: Paracetamol	2.8	4.3	14.1	-2.0	-1.3	-1.3	-3.8	-2.1	-1.1	-1.7
Heel T-Score	2.6	20.9	81.2	-5.2	-4.0	-0.6	-2.1	-9.0	-0.8	-4.1
Sitting height	2.6	18.2	36.3	6.0	2.6	4.6	4.7	5.0	2.8	3.0
Qualifications: College or University degree	2.6	8.1	15.7	-3.2	-3.2	-2.1	-1.8	-1.6	-4.0	-3.2
Ever smoked	2.6	4.5	7.4	-1.6	-2.6	-0.3	-2.7	-2.1	-2.1	-2.5
Angina	2.5	3.3	10.3	1.7	2.0	0.2	1.2	3.2	0.8	2.0
Medication: Ventolin 100micrograms inhaler	2.5	3.2	7.1	-1.5	-2.7	-1.2	-1.3	-0.9	-1.5	-2.6
Diabetes (self-reported)	2.4	3.7	7.6	-2.1	-2.3	-1.9	-0.7	-0.6	-2.8	-2.2
Chronic bronchitis/emphysema (mother)	2.4	2.8	7.0	-2.0	-1.1	-1.6	-2.6	-0.8	-1.5	-1.4
Allergy or Eczema	2.3	6.0	9.5	2.7	2.5	2.5	1.9	1.6	3.1	2.6
Systolic blood pressure, automated reading	2.3	6.6	14.6	3.3	2.0	3.8	1.2	1.7	2.4	2.5
Qualifications: NVQ or HND or HNC or equivalent	2.2	2.6	7.9	-2.1	-1.1	-1.3	-1.3	-2.8	-0.3	-1.2
Eye problems/disorders: Glaucoma	2.2	2.7	6.4	-1.9	-1.6	-0.6	-1.5	-2.5	-0.2	-1.7
Average weekly beer plus cider intake	2.2	3.2	4.9	-2.2	-1.6	-2.1	-1.7	-1.8	-1.4	-1.5
Qualifications: CSEs or equivalent	2.1	2.8	4.3	2.1	1.8	1.2	1.3	1.6	1.7	1.8
Medication: Amlodipine	2.1	3.0	4.0	-1.6	-1.7	-1.5	-1.8	-1.8	-1.6	-2.0
Illnesses of father: High blood pressure	2.1	2.6	5.5	-0.9	-2.0	-0.3	-1.8	-0.6	-2.4	-1.9
Worrier / anxious feelings	2.0	3.7	4.9	-1.8	-2.2	-2.2	-2.0	-0.2	-2.1	-2.1
Ever highly irritable/argumentative for 2 days	2.0	2.4	4.8	-1.5	-2.2	-1.5	-0.2	-0.8	-1.5	-2.1
Glaucoma (self-reported)	2.0	2.4	5.6	-1.7	-1.5	-0.0	-1.5	-2.4	-0.5	-1.8
Hearing aid user	2.0	2.2	3.8	-1.8	-1.3	-1.9	-1.1	-1.1	-1.6	-1.4
Myopia	2.0	2.9	6.4	1.8	1.3	2.5	0.8	1.3	2.1	1.5
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.4	14.5	-2.1	-2.1	-0.4	-1.9	-3.8	-0.4	-1.8
Medication: Simvastatin	1.9	2.8	5.7	-1.9	-1.4	-2.4	-1.1	-0.4	-2.0	-1.7
Hypothyroidism/myxoedema (self-reported)	1.9	3.7	5.6	2.1	1.5	2.3	2.4	0.3	2.4	1.5
Mouth/teeth dental problems: Loose teeth	1.9	2.2	4.2	-1.2	-1.7	-0.8	-1.6	-2.1	-0.8	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.2	5.2	-1.4	-1.1	-2.3	-1.6	-0.7	-1.6	-1.3
Illnesses of father: None of the above (group 1)	1.9	2.3	7.3	0.8	0.9	1.3	1.3	-1.8	2.7	0.9
LDL Cholesterol	1.8	2.8	5.2	-2.3	0.0	-2.0	-1.4	-1.8	-1.5	-1.7
Hearing difficulty/problems with background noise	1.8	2.9	7.8	-2.1	-1.0	-2.8	-1.3	-1.2	-1.5	-1.3
Allergy	1.8	4.2	7.7	-2.1	-1.9	-0.9	-2.8	-1.7	-2.5	-1.9
Angina (self-reported)	1.8	2.3	8.3	1.4	1.6	0.2	0.9	2.9	0.3	1.6
Heart disease (mother)	1.8	2.2	6.8	1.7	0.8	1.2	1.6	2.6	-0.2	0.9
Qualifications: nursing, teaching	1.8	2.8	6.5	-1.5	-2.0	-1.4	-1.0	-0.3	-2.5	-1.9
HbA1C	1.7	1.8	4.7	-0.7	0.0	-2.2	-1.1	0.7	-2.0	-1.4
Hayfever, allergic rhinitis or eczema	1.7	3.7	5.1	2.2	2.0	1.4	1.8	1.8	2.1	2.1
Medication: Levothyroxine sodium	1.7	2.9	6.3	1.8	1.1	2.5	1.8	-0.5	2.4	1.0
Hair/balding pattern: Pattern 2	1.7	2.2	5.7	1.7	1.1	1.5	1.2	2.4	0.7	1.1
Number of children fathered	1.7	1.9	3.8	1.1	1.6	1.7	0.9	-0.1	1.9	1.4
Diabetes diagnosed by doctor	1.7	2.8	6.5	-1.7	-1.7	-2.2	-0.4	-0.1	-2.6	-1.6
Average weekly champagne plus white wine intake	1.7	2.3	5.7	-1.8	-1.5	-0.9	-0.9	-2.4	-1.2	-1.4
Triglycerides	1.6	2.7	5.0	-2.1	0.0	-2.2	-1.7	-1.2	-1.5	-1.7
Medication for pain relief, constipation, heartburn	1.6	2.8	4.2	2.1	1.5	1.9	1.6	1.3	1.4	1.8
Supplements: Vitamin C	1.6	1.9	5.9	1.3	1.7	-0.4	0.5	2.4	0.0	1.7
Ever taken oral contraceptive pill	1.6	1.8	3.9	1.1	1.7	-0.7	1.2	2.0	0.7	1.6
Chronic bronchitis/emphysema (father)	1.5	1.8	4.0	-2.0	-1.5	-0.7	-0.8	-1.7	-0.8	-1.4
Trunk fat-free mass	1.5	8.6	15.8	4.0	1.4	3.1	3.9	3.0	2.1	2.0
Trunk predicted mass	1.5	8.5	15.8	4.0	1.4	3.1	3.9	2.9	2.0	2.0
High blood pressure (siblings)	1.5	2.1	2.9	1.7	1.5	1.6	1.2	1.7	1.0	1.4
Alcohol drinker status: Never	1.5	1.8	4.9	2.0	-0.2	1.6	2.2	0.8	0.6	-0.2
Prostate Cancer	1.4	2.0	4.4	-1.5	0.0	-1.2	-1.8	-2.1	-1.2	-1.1
Systolic Blood Pressure	1.4	6.9	14.5	3.6	2.0	3.8	1.8	2.1	2.1	2.3
Number of treatments/medications taken	1.4	2.5	3.3	-1.8	-1.6	-1.6	-1.8	-0.7	-1.5	-1.7
High blood pressure (mother)	1.4	2.0	3.9	-1.4	-1.6	-0.4	-1.1	-2.0	-0.7	-1.9
Heart attack	1.4	1.7	7.6	0.3	0.8	-1.1	1.2	2.8	-0.8	0.6
Impedance of arm (right)	1.4	6.5	10.6	3.3	2.6	3.0	0.6	2.6	2.5	2.3
Medication: Cholesterol lowering	1.4	2.2	5.2	-1.8	-1.0	-2.3	-1.0	0.0	-1.9	-1.2
Fractured/broken bones in last 5 years	1.4	1.8	3.3	1.8	0.8	0.9	0.7	1.6	1.5	1.5
Medication: Ramipril	1.3	1.6	7.2	-0.5	-0.9	0.6	-2.7	-0.9	-1.1	-0.9
Falls in the last year	1.3	1.8	3.2	-1.2	-1.5	-1.8	-0.7	-1.0	-1.3	-1.6
Number of full brothers	1.3	1.6	2.9	1.7	1.3	1.3	0.9	1.6	0.4	1.1
Wheeze or whistling in the chest in last year	1.3	2.3	8.8	1.2	1.2	1.9	0.4	0.1	3.0	1.2
Age at last live birth	1.3	1.8	5.2	-1.6	-0.6	-2.3	-1.1	-1.0	-1.4	-0.9
Whole body fat-free mass	1.3	7.5	14.1	3.7	1.3	2.8	3.8	2.7	2.1	1.9
Medication: Atorvastatin	1.3	1.6	4.3	0.5	1.8	-0.8	0.4	2.1	0.4	1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	9.2	-1.4	-2.0	-0.0	-1.0	-3.0	-0.4	-1.6
Leg predicted mass (left)	1.2	6.3	12.7	3.2	1.3	2.4	3.6	2.2	2.2	1.9
Had other major operations	1.2	1.5	3.0	1.3	0.8	1.7	1.5	0.8	1.1	0.9
Worry too long after embarrassment	1.2	2.0	4.5	-1.0	-1.6	-1.8	-0.3	0.8	-2.1	-1.4
Leg pain on walking	1.2	1.5	2.3	1.4	1.4	0.3	1.1	0.7	1.5	1.5
Basal metabolic rate	1.2	6.5	13.0	3.4	1.1	2.6	3.6	2.4	2.1	1.7
Heart attack/myocardial infarction (self-reported)	1.2	1.5	6.3	0.1	0.5	-1.3	1.2	2.5	-1.0	0.3
Crohns Disease (2017)	1.1	2.5	4.1	1.0	1.9	-1.0	1.0	1.6	2.0	2.0
Fasting Glucose	1.1	1.4	3.2	-1.3	-1.4	-1.1	-0.5	-1.8	-0.2	-1.0
Lupus	1.1	1.7	5.1	-1.6	-0.8	-1.6	-0.4	-2.2	-0.7	-0.8
Hearing difficulty/problems: Yes	1.1	1.6	5.3	-1.6	-0.6	-2.3	-0.8	-1.2	-0.8	-0.6
Supplements: Zinc	1.1	1.2	3.4	0.3	1.8	0.0	0.1	1.5	0.7	1.6
Diabetes (father)	1.1	1.4	2.4	-1.1	-1.6	-1.4	-0.9	-0.5	-1.1	-1.5
Leg fat-free mass (left)	1.1	6.0	11.9	3.2	1.3	2.4	3.5	2.1	2.2	1.8
Birth weight of first child	1.1	2.0	3.8	1.4	1.5	1.4	0.4	1.1	1.9	1.6
Pulse wave peak to peak time	1.1	1.2	2.5	1.2	1.1	1.6	0.9	-0.1	1.2	1.1
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	2.8	-0.8	-1.3	0.4	-1.7	-1.3	-0.9	-1.1
Whole body water mass	1.1	6.3	13.1	3.4	1.0	2.5	3.6	2.5	1.9	1.7
Tinnitus: Yes, now most or all of the time	1.1	1.2	2.9	-0.9	-1.7	0.2	-0.2	-1.3	-0.6	-1.7
Irritable Bowel Disease (IBD)	1.0	2.3	3.9	1.3	1.9	-1.1	0.4	1.8	1.6	2.0
Neuroticism (2016)	1.0	1.5	2.8	-0.5	-1.1	-1.6	-0.6	0.8	-1.5	-1.7
Medication: Atenolol	1.0	1.3	5.4	1.1	-0.3	0.4	0.5	2.3	-1.4	-0.5
Nervous feelings	1.0	1.9	3.2	-0.9	-1.8	-1.5	-0.7	0.6	-1.8	-1.8
Qualifications: None of the above	1.0	2.1	4.6	2.1	1.0	1.6	0.7	2.1	1.0	1.0
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	2.3	-1.4	-0.9	-1.0	-1.5	-1.0	-0.7	-1.0
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.8	1.1	1.2	1.7	0.1	0.7	0.9	1.4
Diastolic blood pressure, automated reading	1.0	2.9	8.5	-1.7	-1.7	0.2	-2.0	-2.9	-0.6	-1.4
Ever used hormone-replacement therapy (HRT)	0.9	1.1	1.6	1.2	0.8	0.9	1.1	1.1	1.3	0.9
Impedance of leg (right)	0.9	4.4	8.4	2.6	2.2	2.2	0.6	2.9	1.3	1.9
Average weekly fortified wine intake	0.9	1.0	2.4	0.1	1.3	0.3	1.2	-0.6	1.5	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	5.4	0.7	0.8	-0.5	0.5	2.3	-0.2	0.4
Prospective memory result	0.9	1.1	5.4	-0.9	-0.3	-0.5	-2.3	-0.8	-0.8	-0.4
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	3.8	0.9	1.0	1.2	1.0	-0.7	1.9	1.3
Age at first live birth	0.9	1.6	2.6	-1.6	-0.9	-1.1	-1.1	-1.6	-1.4	-0.9
Illnesses of father: Heart disease	0.9	1.2	4.0	-0.1	-0.2	-1.3	0.2	2.0	-1.7	-0.2
Leg fat-free mass (right)	0.9	4.8	10.2	2.9	0.9	2.1	3.2	2.0	1.9	1.5
Long-standing illness, disability or infirmity	0.9	1.4	6.6	-1.3	-0.6	-2.6	-0.4	0.4	-0.7	-0.6
Leg predicted mass (right)	0.9	4.9	10.2	3.0	0.9	2.1	3.2	2.1	1.9	1.5
Arm fat-free mass (left)	0.9	4.5	10.1	2.8	0.5	2.3	3.2	2.1	1.5	1.1
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	1.8	0.8	1.4	-0.4	1.1	1.1	1.2	1.4
Mean Putamen Volume	0.8	1.0	3.9	1.1	0.0	2.0	-0.1	0.5	1.1	0.4
Hypothyroidism (self reported)	0.8	1.9	4.4	1.3	1.1	1.8	1.3	-0.5	2.1	1.0
Neuroticism	0.8	1.9	3.0	-1.2	-1.7	-1.6	-0.0	0.6	-1.6	-1.7
Current tobacco smoking	0.8	1.3	4.3	-0.9	-0.9	-0.8	-0.4	-2.1	0.3	-1.4
Age when periods started (menarche)	0.8	1.8	4.2	2.1	1.2	1.6	0.6	1.6	0.4	1.2
Neuroticism score	0.8	1.7	3.7	-0.9	-1.9	-1.3	-0.5	0.2	-1.4	-1.8
Qualifications: A levels/AS levels or equivalent	0.8	1.7	3.3	-1.7	-0.9	-1.1	-1.5	-0.9	-1.8	-0.9
Birth weight	0.8	1.7	3.5	0.9	1.6	-0.4	1.6	1.9	0.5	1.4
Medication: Allopurinol	0.8	1.0	3.7	-1.2	-0.8	-0.6	-0.7	-1.9	0.2	-0.7
Chest pain or discomfort	0.8	1.1	2.5	-1.6	-0.9	-1.4	-0.3	-1.3	0.1	-1.0
Number of operations (self-reported)	0.8	1.3	2.2	1.0	1.0	1.3	1.5	0.5	1.2	1.1
Age started oral contraceptive pill	0.8	1.0	4.6	0.7	0.5	0.4	1.0	2.1	0.0	0.6
Supplements: Calcium	0.8	0.9	2.5	0.9	0.5	0.3	1.1	1.6	0.3	1.1
Alcohol drinker status: Previous	0.8	0.9	2.7	-0.9	-0.5	-1.6	-0.5	0.1	-1.3	-0.4
Major Depression (MDD)	0.7	0.8	2.2	1.4	0.0	1.5	0.6	0.8	0.9	0.2
Type 2 Diabetes (T2D) (2012)	0.7	0.9	4.9	-0.8	0.0	-2.2	0.2	-0.4	0.5	-0.0
Chronotype (morning person)	0.7	1.7	5.7	0.1	-0.7	-1.5	-0.1	1.7	-2.4	-0.6
Medication for hormone replacement therapy	0.7	0.8	1.8	-0.9	-0.9	-1.4	0.6	-0.5	-0.8	-0.8
Past tobacco smoking	0.7	1.2	3.0	0.2	1.4	-0.2	1.3	-0.1	1.7	1.4
Mouth/teeth dental problems	0.7	1.0	2.0	-1.2	-1.0	-1.4	-0.8	0.0	-1.1	-1.0
Illnesses of mother	0.7	0.9	2.4	0.4	1.3	0.1	1.1	0.4	0.7	1.5
Impedance of arm (left)	0.7	3.2	5.5	2.3	1.8	2.3	0.3	1.6	1.8	1.6
Breastfed as a baby	0.7	0.9	1.5	-0.7	-1.2	-0.5	-0.2	-1.0	-1.2	-1.2
Number of full sisters	0.7	0.9	2.1	0.2	-0.9	-0.7	-0.4	1.4	-1.4	-0.7
Breast cancer (self-reported)	0.7	0.9	3.0	0.8	0.5	1.7	1.1	-0.5	0.8	0.5
Arm predicted mass (left)	0.7	3.8	9.5	2.5	0.4	1.9	3.1	2.0	1.2	1.0
Worry (Nagel 2018)	0.6	1.3	3.3	-1.1	0.0	-1.1	-0.2	-0.5	-1.8	-1.8
Alzheimer’s Disease (including proxy)	0.6	0.9	2.6	-0.0	0.7	-0.3	0.6	-1.6	1.4	0.8
Verbal and Numeric Reasoning (VNR)	0.6	1.4	3.7	-0.4	-1.4	-0.7	-1.1	-0.2	-1.9	-1.4
Crohns Disease (2012)	0.6	0.9	2.8	0.4	0.0	-0.8	-0.4	1.7	1.2	1.1
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.2	-1.5	-1.0	-0.9	-0.4	-0.6	-0.4	-0.8
Townsend deprivation index at recruitment	0.6	0.9	2.6	-0.8	-0.8	-1.6	0.4	-0.2	-1.1	-1.0
Maternal smoking around birth	0.6	0.9	4.2	0.4	-0.0	2.0	-0.3	-0.6	1.2	0.2
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.5	1.0	-0.1	1.2	0.5	1.1	0.8	-0.0
High blood pressure	0.6	1.7	4.0	-0.2	-2.0	-0.5	-1.2	-0.5	-1.6	-1.8
Forced vital capacity (FVC)	0.6	2.4	5.7	2.4	0.5	1.9	0.8	2.4	0.1	0.9
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.1	1.0	-0.2	0.0	1.3	1.4	0.6	-0.1
Financial difficulties in last 2 years	0.6	0.8	2.5	0.0	0.7	0.5	0.6	-1.2	1.6	0.6
Weight	0.6	3.0	6.6	2.3	0.3	1.9	2.6	1.4	1.6	0.8
Father’s age at death	0.6	0.8	3.5	-1.0	-0.4	-0.2	-0.4	-1.9	0.1	-0.8
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	6.4	1.9	0.8	1.0	1.0	2.5	-0.0	1.1
Medication: Lansoprazole	0.6	0.7	3.3	-1.1	-0.1	-1.8	-0.1	0.1	0.3	-0.2
Blood clot in the leg (DVT)	0.6	0.8	1.2	0.7	1.1	-0.3	0.8	1.1	1.0	1.1
Forced vital capacity (FVC), Best measure	0.6	2.2	5.9	2.2	0.5	1.6	1.2	2.4	-0.0	0.9
Arm fat-free mass (right)	0.6	3.3	8.4	2.4	0.4	1.7	2.9	1.6	1.4	1.0
Emphysema/chronic bronchitis	0.6	0.7	2.8	0.5	0.2	0.4	1.3	-0.5	1.7	-0.1
Medication: Ibuprofen	0.6	0.7	1.5	-1.2	-0.4	-0.8	-1.1	-0.9	-0.2	-0.5
Arm predicted mass (right)	0.6	3.2	7.5	2.5	0.3	1.9	2.7	1.7	1.2	0.9
Alcohol intake frequency.	0.6	1.4	3.5	-1.1	-1.6	-0.5	-0.6	-0.8	-1.2	-1.9
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.0	0.7	0.9	0.4	0.2	1.4	1.0	0.8
Medication: Aspirin	0.6	0.7	2.8	-0.4	-0.8	-0.6	-0.1	0.9	-1.7	-0.7
Medication: Gliclazide	0.6	0.7	1.9	-0.9	-0.2	-1.0	0.3	0.9	-1.4	-0.1
Smoking status: Current	0.6	1.0	3.0	-0.9	-0.7	-1.0	-0.1	-1.7	0.4	-1.2
Irritability	0.6	1.0	4.8	0.5	-0.2	0.1	0.7	2.2	-1.1	-0.1
Impedance of whole body	0.6	2.9	4.8	2.2	1.7	2.2	0.1	1.9	1.5	1.4
Intelligence (Savage-Jansen 2018)	0.5	1.4	5.1	-0.9	0.0	-0.8	-0.5	-0.2	-2.2	-1.9
Blood Red Count	0.5	4.4	14.0	2.2	1.8	0.6	2.1	3.7	-0.4	1.9
Vitamin and mineral supplements	0.5	0.7	1.6	0.5	-0.7	0.9	1.3	-0.9	0.3	-0.8
Stomach or abdominal pain in last month	0.5	0.6	1.4	1.2	0.9	0.1	0.2	0.8	1.0	0.8
Impedance of leg (left)	0.5	2.4	5.8	1.9	1.6	1.6	0.0	2.4	1.0	1.3
Number of incorrect matches in round	0.5	0.8	1.1	0.7	1.0	0.4	1.0	1.0	0.9	0.9
Pain all over the body in last month	0.5	0.6	1.6	0.3	0.2	-0.9	1.0	1.3	-0.2	0.4
Hip circumference	0.5	2.0	5.2	1.6	0.3	1.4	2.3	1.0	1.8	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	4.4	1.8	0.6	1.0	1.0	2.1	-0.3	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	2.6	-0.5	-0.6	-1.6	-0.4	0.9	-0.6	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	3.2	-0.5	0.4	-1.8	0.3	0.6	0.2	0.4
Illnesses of siblings: Diabetes	0.5	0.6	1.0	-0.6	-1.0	0.1	0.9	-0.8	-0.5	-1.0
Smoking status: Previous	0.5	0.7	1.5	0.6	-0.9	0.8	-0.8	1.0	-1.2	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	2.6	1.0	0.3	0.3	1.6	0.9	0.6	0.4
Wears glasses or contact lenses	0.5	0.6	1.6	-0.7	-0.7	-0.4	-1.0	-1.3	0.0	-0.7
Alzheimer’s Disease (in mother)	0.4	0.5	2.2	-0.0	0.2	-0.1	0.4	-1.5	0.9	-0.0
Alzheimer’s Disease (in father)	0.4	0.5	1.1	0.5	1.0	-0.1	0.8	0.1	0.6	1.1
Waist Hip Ratio (WHR)	0.4	1.7	3.5	1.4	1.6	0.9	1.1	0.4	1.9	1.4
Respiratory disease	0.4	1.0	2.4	-0.6	-1.1	-0.0	-0.6	-1.5	1.0	-1.2
Hair Pigment	0.4	10.9	37.6	4.1	2.0	2.4	2.4	6.1	0.1	2.4
Ever had hysterectomy (womb removed)	0.4	0.5	1.5	0.4	-0.4	0.0	1.2	1.1	-0.0	-0.0
Diabetes (mother)	0.4	0.5	1.6	-0.1	-0.2	-1.3	0.3	0.7	-1.1	-0.1
Severe depression (siblings)	0.4	0.4	0.8	-0.8	-0.2	-0.7	-0.4	-0.9	-0.9	-0.4
Serious illness, injury or assault to yourself	0.4	0.5	1.1	0.3	0.9	-0.5	1.1	0.3	0.4	1.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	2.2	0.2	0.4	0.7	1.5	-0.3	0.5	0.0
Trunk fat mass	0.4	1.8	4.3	1.5	0.5	1.2	2.1	1.0	1.6	0.6
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	2.1	0.6	0.4	0.8	0.3	-0.4	1.4	0.5
Mouth/teeth dental problems: Dentures	0.4	0.6	3.1	-0.2	-0.4	0.4	0.4	-1.8	0.6	-0.4
Asthma	0.4	0.9	2.2	-0.8	-1.1	-0.6	0.2	-1.5	0.8	-1.1
Pulse wave Arterial Stiffness index	0.4	0.5	1.0	-0.5	-0.7	-1.0	-0.5	0.5	-0.8	-0.7
Gout (self-reported)	0.4	0.6	1.9	0.0	-0.2	1.1	0.3	-1.4	1.0	0.1
Exposure to tobacco smoke outside home	0.4	0.5	2.1	-0.8	0.5	-1.5	-0.8	0.1	-0.2	0.3
Health satisfaction	0.4	0.5	1.3	0.8	1.2	0.4	-0.1	0.2	0.6	1.1
Shortness of breath walking on level ground	0.4	0.5	1.6	0.0	-1.3	0.0	0.4	0.5	-0.4	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	0.9	0.9	0.4	0.9	0.5	-0.4	0.7	0.5
Overall health rating	0.4	0.8	1.9	-1.1	-0.5	-1.4	-1.0	-0.9	0.1	-0.7
Medication: Aspirin	0.4	0.6	1.9	-0.0	-0.5	-0.4	0.4	1.2	-1.4	-0.3
Back pain experienced in last month	0.4	0.6	1.7	-0.7	0.5	-1.3	-0.3	-0.3	1.2	0.2
Number of self-reported non-cancer illnesses	0.4	0.6	1.8	-0.2	-1.4	-0.5	0.6	0.6	-0.5	-1.1
Commuting to job workplace: Public transport	0.4	0.5	1.0	-0.9	-1.0	-0.2	-0.1	-0.8	-0.4	-1.0
Ever had prostate specific antigen (PSA) test	0.4	0.5	2.4	-0.3	-0.3	0.4	-0.6	-1.5	-0.2	-0.6
Neuroticism (Nagel 2018)	0.3	0.8	2.9	-0.6	0.0	-0.3	0.4	0.2	-1.7	-1.5
Schizophrenia vs Biploar Disorder	0.3	0.3	1.0	0.8	0.0	1.0	0.3	0.8	0.1	0.3
Ovarian Cancer	0.3	0.3	1.0	-0.9	0.1	-1.0	-0.3	-0.4	-0.5	0.0
Body Mass Index (BMI) (2010)	0.3	0.5	1.8	0.5	0.0	0.1	1.3	0.9	0.4	0.5
HDL Cholesterol	0.3	0.5	1.4	-0.9	0.0	-0.1	-0.5	-1.2	-0.3	-1.0
Primary Biliary Cirrhosis	0.3	0.4	1.2	-0.9	0.0	-0.2	-1.1	-0.7	0.0	-0.5
Blood Eosinophil Count	0.3	2.5	3.4	1.6	1.8	1.4	1.7	1.4	1.4	1.7
BMI	0.3	1.7	2.7	-1.4	-1.6	-0.6	1.0	-1.6	-0.5	-1.6
Smoking Status	0.3	0.7	1.8	-0.6	-0.9	-0.2	-0.4	-1.3	0.2	-1.2
Hand grip strength (left)	0.3	0.9	2.4	-0.7	-1.5	0.2	-0.4	-0.7	-1.3	-1.1
Average weekly spirits intake	0.3	0.4	1.1	0.4	0.8	0.1	-0.2	1.1	0.8	0.4
Pack years adult smoking proportion	0.3	0.4	1.3	-0.9	-0.7	-0.0	-0.0	-1.1	-0.1	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	-0.5	-0.9	-0.7	0.2	-0.5	0.1	-0.8
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.0	1.0	0.1	0.2	0.2	0.9	0.3	-0.0
Multivitamins +/- minerals	0.3	0.4	1.8	-0.4	0.5	-0.4	-1.3	0.6	-0.4	0.5
Supplements: Glucosamine	0.3	0.4	0.8	-0.5	0.8	-0.9	-0.2	0.2	-0.8	0.5
Body mass index (BMI)	0.3	1.4	2.3	-1.5	-1.4	-1.4	0.4	-1.3	-0.6	-1.2
Waist circumference	0.3	0.9	3.1	1.0	0.1	0.6	1.8	0.4	1.4	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.0	0.0	-0.7	-0.5	1.0	0.8	-0.4	-0.7
Fluid intelligence score	0.3	0.7	1.4	-0.4	-1.2	-0.0	-0.9	-0.4	-1.2	-1.0
Depression (self-reported)	0.3	0.4	1.5	0.2	0.4	-0.2	1.2	0.2	0.7	0.5
Peak expiratory flow (PEF)	0.3	0.8	2.0	-0.2	-1.4	-0.7	-0.3	0.4	-1.2	-1.1
Loud music exposure frequency	0.3	0.4	0.9	0.8	0.5	-0.2	0.9	0.2	0.6	0.6
Comparative body size at age 10	0.3	0.9	3.9	-1.1	-0.5	-0.8	-0.3	-2.0	0.0	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.2	-0.0	-1.0	0.3	-0.3	-1.1	-0.0	-0.7
Medication: Blood pressure	0.3	0.6	1.6	-0.3	-0.6	-0.4	-1.3	0.3	-1.1	-0.8
Medication: Omeprazole	0.3	0.3	1.0	0.1	0.3	-1.0	0.7	0.6	0.2	0.2
Medication: Seretide 50 evohaler	0.3	0.4	0.9	0.3	0.9	0.3	-0.3	0.5	0.7	0.9
Pulse rate, automated reading	0.3	1.1	3.0	-1.7	-0.3	-1.2	-0.4	-1.6	-0.6	-0.2
Suffer from ‘nerves’	0.3	0.5	1.1	-0.7	-0.4	-1.1	1.0	-0.1	-0.1	-0.7
Had major operations	0.3	0.3	2.2	-0.1	-0.1	1.5	-0.2	-0.4	-0.0	-0.1
Family relationship satisfaction	0.3	0.3	1.2	1.1	0.4	0.5	0.1	0.2	0.7	0.1
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.3	0.5	0.0	1.1	-0.3	-0.7	0.4	0.2
Knee pain experienced in last month	0.3	0.5	0.9	0.7	0.8	0.0	0.6	0.8	1.0	0.9
Hypertension (Self-reported)	0.3	0.9	2.2	0.2	-1.5	0.1	-1.1	-0.3	-1.1	-1.3
Eye problems/disorders: Cataract	0.3	0.3	0.6	0.2	0.6	0.8	0.5	0.1	0.5	0.8
Medication for cholesterol	0.3	0.4	1.4	0.6	0.0	1.2	0.7	-0.7	0.6	-0.2
Mineral and other dietary supplements	0.3	0.5	1.6	1.0	0.0	1.3	0.5	-0.2	0.7	-0.0
Osteoporosis (self-reported)	0.3	0.3	1.4	0.0	0.1	0.6	-1.2	-0.3	0.5	0.1
Miserableness	0.3	0.5	0.9	-0.5	-0.9	-0.9	-0.5	-0.3	-0.9	-0.9
Financial situation satisfaction	0.3	0.4	1.1	0.4	-0.1	0.9	-0.8	-1.0	-0.1	-0.3
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.4	-0.9	0.1	-0.9	-1.2	0.1	-0.2	-0.1
High cholesterol (Self-reported)	0.3	0.5	1.3	-0.9	-0.3	-1.1	0.1	0.0	-0.8	-0.7
Medication: Bendroflumethiazide	0.3	0.4	0.9	0.9	0.2	0.7	-0.7	0.9	-0.1	0.3
Risk taking	0.3	0.4	1.0	0.3	-0.6	0.1	-0.9	-1.0	-0.3	-0.4
Unable to work because of sickness or disability	0.3	0.4	0.8	0.6	0.6	0.2	0.6	0.8	0.1	0.9
Cholesterol lowering medication	0.3	0.4	1.9	0.1	0.6	-0.4	0.5	1.4	-0.3	0.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	2.1	-0.6	-0.0	-1.4	0.3	0.1	-0.2	-0.1
Basal cell carcinoma (self-reported)	0.3	0.3	0.9	1.0	0.7	0.1	0.4	0.5	0.3	0.5
Pack years of smoking	0.3	0.4	1.3	-0.9	-0.6	-0.1	0.0	-1.2	0.1	-0.5
Bipolar Disorder or Schizophrenia	0.2	0.4	1.0	-0.1	0.0	-1.0	-0.6	1.0	-0.2	0.7
Depressed Affect (Nagel 2018)	0.2	0.5	1.5	-0.5	0.0	-0.2	0.4	-0.3	-1.2	-1.1
Schizophrenia (2018)	0.2	0.5	1.9	0.1	0.0	-1.0	-0.6	1.4	-0.6	0.3
Ulcerative Colitis (UC)	0.2	0.3	0.8	0.4	0.5	-0.9	-0.5	0.2	0.5	0.6
Schizophrenia (2014)	0.2	0.4	1.4	-0.0	0.0	-0.9	-0.5	1.2	-0.6	0.2
Ulcerative Colitis	0.2	0.3	1.0	0.7	0.0	-0.2	0.4	1.0	0.5	0.6
Lung FEV1/FVC ratio	0.2	0.9	2.5	0.0	0.2	-0.9	-1.0	1.6	-1.5	-0.1
Relative age of first facial hair	0.2	0.5	1.7	0.1	1.3	-0.4	0.2	0.7	-0.0	0.9
Trunk fat percentage	0.2	0.7	2.0	0.8	0.4	0.6	1.2	0.5	1.4	0.3
Fed-up feelings	0.2	0.3	1.0	0.3	-0.9	0.2	-0.1	-0.2	-0.5	-1.0
Alcohol usually taken with meals	0.2	0.4	1.0	0.7	0.4	0.7	0.1	1.0	-0.2	0.4
Time employed in main current job	0.2	0.3	0.8	-0.3	-0.6	-0.6	0.4	-0.9	0.0	-0.5
Alcohol intake versus 10 years previously	0.2	0.3	1.2	0.0	0.6	1.1	-0.6	-0.3	0.6	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.7	0.3	0.1	-0.6	0.9	0.8	0.7	0.3
Number of live births	0.2	0.3	0.9	0.5	0.9	0.1	0.1	0.6	0.3	0.6
Pulse rate	0.2	0.3	0.5	-0.6	0.7	-0.7	-0.7	-0.1	-0.1	0.7
Length of working week for main job	0.2	0.2	0.7	-0.0	-0.3	0.4	0.3	-0.9	0.5	-0.1
Exposure to tobacco smoke at home	0.2	0.2	0.5	-0.1	0.4	0.3	0.5	-0.6	0.7	0.3
Tense / ‘highly strung’	0.2	0.3	0.8	-0.2	-0.5	-0.9	0.3	0.6	-0.0	-0.5
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.6	-0.7	0.1	-0.3	0.5	-1.3	0.4	0.2
Neck or shoulder pain in last month	0.2	0.2	1.0	0.0	-0.1	-0.8	-0.1	0.0	1.0	-0.4
Mean time to correctly identify matches	0.2	0.3	1.3	-0.6	0.0	-0.2	-0.6	-1.1	0.5	-0.0
Whole body fat mass	0.2	0.9	3.1	1.0	0.1	0.6	1.8	0.5	1.2	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.2	0.0	-1.1	0.2	0.5	0.4	-0.6	-0.9
Arm fat percentage (left)	0.2	0.8	1.3	-1.1	-0.9	-1.1	0.1	-1.1	-0.1	-0.9
Average weekly red wine intake	0.2	0.3	0.7	0.6	0.2	0.8	0.1	-0.2	0.9	0.2
Ever had bowel cancer screening	0.2	0.2	0.4	-0.4	-0.6	-0.4	0.0	-0.6	0.2	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	0.2	-0.5	0.1	0.6	0.0	-0.7	-0.3
Friendships satisfaction	0.2	0.3	1.1	0.7	0.1	1.1	0.3	0.4	0.2	-0.0
Commuting to job workplace: Walk	0.2	0.2	0.9	0.4	0.5	1.0	0.1	-0.0	0.5	0.2
Asthma (self-reported)	0.2	0.5	0.8	-0.3	-0.8	-0.4	0.4	-0.9	0.9	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.2	-0.1	-0.1	-1.1	-0.4	1.0	-1.1	-0.2
Guilty feelings	0.2	0.4	0.9	-0.5	-0.9	-0.5	0.3	-0.4	-0.2	-0.9
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.5	0.2	0.7	0.1	0.6	0.3	0.7	0.6
Medication: Lisinopril	0.2	0.3	0.7	-0.3	0.6	-0.8	0.1	-0.0	0.8	0.6
Leg fat percentage (left)	0.2	0.6	2.0	-1.0	-0.6	-1.4	0.6	0.0	-0.2	-0.7
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.2	-0.5	1.0	0.2	0.6	-0.8	1.1	0.9
Pain experienced in last month	0.2	0.3	0.9	0.4	0.4	1.0	-0.4	0.0	-0.4	0.5
Bipolar Disorder (2018)	0.1	0.1	0.6	-0.3	0.0	-0.3	-0.2	-0.2	0.4	0.8
Depression (Nagel 2018)	0.1	0.2	0.3	-0.5	0.0	-0.5	0.3	-0.2	-0.5	-0.5
Reaction Time	0.1	0.1	0.2	-0.4	0.1	-0.2	-0.4	-0.5	0.0	0.2
Breast Cancer	0.1	0.2	0.7	-0.5	0.0	-0.8	-0.1	0.1	-0.4	0.0
Age at First Birth	0.1	0.1	0.4	-0.2	-0.0	-0.2	-0.0	0.3	-0.7	-0.2
Rheumatoid Arthritis	0.1	0.2	0.4	0.5	0.0	0.6	0.3	0.2	0.6	0.2
Blood Platelet Count	0.1	0.9	3.6	0.4	1.2	-0.1	-0.3	1.9	-0.1	1.2
Cardiovascular Disease	0.1	0.3	0.4	0.7	-0.5	0.0	-0.2	0.7	-0.6	-0.6
Lung FVC	0.1	0.4	1.0	-0.7	0.1	-0.4	-0.9	0.5	-1.0	0.1
Tanning	0.1	0.6	1.4	-0.3	-0.9	-1.1	-0.0	0.5	-0.8	-1.2
Sensitivity / hurt feelings	0.1	0.2	0.5	-0.3	-0.6	-0.1	0.3	0.2	0.4	-0.7
Medication: Co-codamol	0.1	0.1	0.4	0.1	0.5	-0.7	-0.1	0.4	0.4	0.2
Hand grip strength (right)	0.1	0.1	0.5	-0.1	-0.7	-0.0	0.0	-0.5	-0.5	-0.3
Relative age voice broke	0.1	0.2	0.4	0.1	0.6	-0.1	-0.4	0.4	0.0	0.6
Taking other prescription medications	0.1	0.1	0.4	0.1	-0.6	-0.0	0.1	0.4	-0.1	-0.5
Had menopause	0.1	0.2	0.7	-0.1	-0.8	0.2	0.2	0.0	0.1	-0.6
Arm fat percentage (right)	0.1	0.3	0.7	-0.7	-0.6	-0.9	0.3	-0.5	0.0	-0.6
Happiness	0.1	0.2	0.5	0.6	0.4	-0.2	-0.2	0.7	0.4	0.1
Noisy workplace	0.1	0.2	0.6	0.3	0.1	-0.2	0.3	0.8	-0.5	-0.1
Lung cancer (father)	0.1	0.1	0.1	0.2	-0.3	0.0	-0.1	-0.1	0.4	-0.3
Arm fat mass (right)	0.1	0.3	1.6	0.2	-0.3	-0.0	1.3	-0.1	0.7	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.5	0.2	-0.7	-0.1	-0.0	-0.0	0.1	-0.4
Leg fat percentage (right)	0.1	0.4	1.1	-0.7	-0.4	-1.0	1.0	0.1	-0.1	-0.5
Eye problems/disorders: None of the above	0.1	0.1	0.4	0.7	-0.0	-0.3	0.3	0.2	-0.2	-0.1
Leg fat mass (right)	0.1	0.5	2.7	0.3	-0.1	-0.2	1.7	0.6	0.5	0.0
Mood swings	0.1	0.2	0.5	0.4	-0.4	-0.2	0.3	0.7	-0.5	-0.2
Loneliness, isolation	0.1	0.2	0.6	0.2	-0.1	-0.4	0.8	-0.3	0.4	-0.3
Arm fat mass (left)	0.1	0.3	1.3	-0.0	-0.7	-0.2	1.2	-0.2	0.3	-0.4
Mother’s age at death	0.1	0.2	0.9	-0.3	-0.1	0.0	-0.3	-0.9	-0.0	-0.3
Medication: Blood pressure	0.1	0.1	0.4	0.5	0.2	0.2	-0.2	0.6	0.2	0.5
Ever depressed for a whole week	0.1	0.2	0.4	0.3	-0.4	0.0	0.6	0.4	0.4	-0.3
Commuting to job workplace: Cycle	0.1	0.1	0.4	0.3	-0.3	0.2	0.2	0.1	0.6	0.1
Leg fat mass (left)	0.1	0.4	2.0	0.1	-0.2	-0.4	1.4	0.4	0.5	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood White Count	0.0	0.1	0.5	0.0	-0.2	-0.1	0.7	0.2	-0.3	-0.1
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.1	-0.2	0.3	0.0	0.2	0.2	0.4	0.0
Body fat percentage	0.0	0.2	0.6	-0.2	-0.2	-0.4	0.7	-0.1	0.6	-0.3

Hub : Genes

B9D2

Models

Trait associations