Best TWAS P=1.96e-43 · Best GWAS P=2.59e-55 conditioned to 6.38e-14
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | RP3-511B24.6 | 0.21 | 0.00 | lasso | 5 | 0.00 | 2.5e-01 | -8.9 | 10.1 | 7.6e-24 | -0.61 | 0.06 | 0.12 | FALSE |
| 2 | GTEx | Skin Sun Exposed Lower leg | LPIN3 | 0.12 | 0.01 | lasso | 5 | 0.02 | 3.5e-03 | 1.0 | 7.6 | 3.6e-14 | -0.35 | 0.74 | 0.03 | FALSE |
| 3 | GTEx | Thyroid | LPIN3 | 0.29 | 0.08 | lasso | 10 | 0.04 | 3.3e-04 | -14.2 | 12.0 | 5.0e-33 | -0.76 | 0.95 | 0.01 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | EMILIN3 | 0.08 | 0.06 | lasso | 5 | 0.08 | 2.7e-09 | -6.7 | -9.1 | 8.2e-20 | 0.59 | 0.95 | 0.05 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ZHX3 | 0.04 | 0.02 | lasso | 2 | 0.02 | 2.4e-03 | -14.2 | -13.8 | 2.0e-43 | 0.84 | 0.03 | 0.23 | TRUE |
| 6 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | LPIN3 | 0.10 | 0.02 | lasso | 5 | 0.07 | 6.1e-04 | -9.0 | -7.0 | 2.3e-12 | 0.41 | 0.02 | 0.17 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PLCG1 | 0.03 | 0.00 | blup | 35 | 0.02 | 3.5e-03 | -7.1 | 9.2 | 2.9e-20 | -0.63 | 0.02 | 0.56 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZHX3 | 0.05 | 0.06 | lasso | 2 | 0.05 | 2.6e-06 | -7.0 | 6.3 | 2.2e-10 | -0.53 | 0.91 | 0.03 | FALSE |