[Hub]/) : Traits : Heel T-Score : ← →

chr20:43,825,556-46,516,716

Best TWAS P=1.72e-37 · Best GWAS P=2.34e-45 conditioned to 1.18e-12

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Visceral Omentum NEURL2 0.20 0.06 lasso 3 0.06 4.2e-04 6.9 -6.6 4.0e-11 -0.03 0.00 0.99 FALSE
2 GTEx Artery Aorta EYA2 0.42 0.32 lasso 6 0.34 1.6e-19 8.0 -8.4 2.9e-17 0.09 1.00 0.00 TRUE
3 GTEx Esophagus Gastroesophageal Junction ZNF334 0.41 0.35 enet 31 0.31 5.4e-12 4.3 5.7 1.1e-08 -0.08 1.00 0.00 TRUE
4 GTEx Nerve Tibial PLTP 0.11 0.01 enet 27 0.01 4.6e-02 4.8 -5.7 1.4e-08 0.04 0.05 0.70 FALSE
5 GTEx Skin Not Sun Exposed Suprapubic NEURL2 0.17 0.09 lasso 4 0.03 8.7e-03 5.3 -6.1 1.4e-09 0.03 0.05 0.74 FALSE
6 GTEx Thyroid EYA2 0.29 0.16 enet 51 0.15 1.0e-11 -12.3 -12.8 1.7e-37 0.75 0.11 0.89 TRUE
7 METSIM Adipose EYA2 0.05 0.01 enet 21 0.03 6.6e-05 4.6 -9.2 2.6e-20 0.42 0.08 0.84 FALSE
8 ROSMAP Brain Pre-frontal Cortex CTSA 0.15 0.06 enet 20 0.12 7.7e-15 6.2 -6.0 2.6e-09 0.02 0.00 1.00 FALSE
9 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MMP9 0.02 0.02 blup 46 0.02 3.5e-03 6.3 -5.3 1.3e-07 0.02 0.00 0.91 FALSE
10 The Cancer Genome Atlas Pancreatic Adenocarcinoma PLTP 0.34 0.00 lasso 3 0.05 2.8e-03 6.9 -6.7 1.7e-11 -0.02 0.00 0.61 TRUE
11 The Cancer Genome Atlas Prostate Adenocarcinoma ZSWIM1 0.04 0.07 blup 41 0.05 4.3e-06 4.0 5.4 7.7e-08 -0.05 0.99 0.00 FALSE
12 The Cancer Genome Atlas Thyroid Carcinoma EYA2 0.36 0.14 enet 18 0.28 9.0e-28 -12.3 -10.3 8.3e-25 0.54 0.99 0.01 FALSE