TWAS hub - PLCG1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cortex	0.2420	0.0850	0.00130	0.000	NA	-0.006	NA	0.008	0.310	NA	5.0e-01	NA	0.1900
2	GTEx	Esophagus Mucosa	0.1860	0.0570	0.00037	0.016	NA	0.086	NA	0.029	0.027	NA	2.1e-06	NA	0.0048
3	TCGA	Prostate Adenocarcinoma	0.0281	0.0176	0.00540	0.000	0.02	0.010	NA	0.004	0.290	0.0035	2.6e-02	NA	0.1000

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
LDL Cholesterol	12.0	19.1	47.4	1.9	2.5	-6.9
High cholesterol (Self-reported)	5.5	9.7	19.5	1.7	2.6	-4.4
Medication: Simvastatin	4.7	6.9	16.0	1.1	1.9	-4.0
Diabetes (mother)	4.6	5.9	17.5	-0.1	-0.3	-4.2
Hair/balding pattern: Pattern 3	4.2	6.2	15.2	-0.0	-1.9	3.9
Cholesterol lowering medication	4.0	5.9	12.2	0.7	2.2	-3.5
Neuroticism (2016)	3.9	5.6	15.6	-0.4	1.0	-4.0
Heel T-Score	3.7	29.2	85.0	1.3	-0.9	9.2
Medication: Cholesterol lowering	3.4	5.2	12.4	1.3	1.3	-3.5
Medication: Omeprazole (e.g. Zanprol)	3.4	4.1	11.1	3.3	-1.1	0.2
Hair/balding pattern: Pattern 2	3.1	4.0	7.2	2.2	0.2	-2.7
Medication: Atenolol	3.0	3.7	5.5	-2.4	1.2	-2.1
Heel bone mineral density (BMD) T-score, automated (right)	3.0	6.8	18.1	1.5	-0.3	4.3
Type 2 Diabetes (T2D) (2012)	2.9	3.3	6.8	0.7	-1.6	-2.6
Hair/balding pattern: Pattern 4	2.9	6.9	20.6	-0.3	0.3	4.5
Waist Hip Ratio (WHR)	2.8	12.4	35.2	1.4	0.1	-5.9
Diabetes (father)	2.8	3.4	5.5	-1.8	-2.3	-1.2
Medication: Omeprazole	2.8	3.3	9.3	3.0	-0.8	-0.3
Commuting to job workplace: Car/motor vehicle	2.8	3.2	6.8	-1.0	-2.6	1.3
Heel bone mineral density (BMD) T-score, automated (left)	2.6	5.8	15.5	1.0	-0.9	3.9
Supplements: Vitamin C	2.6	3.1	5.5	-1.7	-2.3	0.9
Hearing difficulty/problems with background noise	2.5	3.9	10.3	-0.6	1.1	3.2
Pulse rate	2.5	4.2	5.4	2.3	-1.4	-2.3
Number of full sisters	2.5	3.0	5.3	-2.3	1.8	0.9
Medication: Atorvastatin	2.5	3.1	5.3	2.3	0.6	-1.9
Alcohol intake frequency.	2.4	5.5	13.3	-1.8	-0.2	-3.6
Pain type(s) experienced in last month: Hip pain	2.3	2.9	4.5	-1.3	-1.6	-2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	2.2	3.4	8.5	1.2	-0.5	-2.9
Commuting to job workplace: Walk	2.2	2.4	3.5	1.9	1.6	-1.1
Bipolar Disorder (2011)	2.1	2.1	4.5	-0.7	-1.1	2.1
Vitamin and mineral supplements	2.1	2.9	7.5	2.7	1.0	-0.4
Breastfed as a baby	2.1	2.6	3.6	1.3	1.6	1.9
Pulse wave reflection index	2.1	2.6	3.5	-1.8	1.0	1.9
Medication for pain relief, constipation, heartburn	2.1	3.6	5.4	-2.3	0.7	2.2
Breast Cancer	2.0	4.8	5.5	2.3	-2.3	1.9
Angina	2.0	2.6	6.1	-0.5	2.5	-1.2
Qualifications: CSEs or equivalent	2.0	2.7	4.2	-1.2	-2.1	1.5
Loneliness, isolation	2.0	2.8	8.1	-0.4	-2.9	-0.2
Mineral and other dietary supplements	2.0	2.8	4.5	1.5	1.2	-2.1
Diastolic blood pressure, automated reading	1.9	5.8	15.3	-1.0	1.0	3.9
Alcohol drinker status: Previous	1.9	2.1	6.2	0.4	0.1	-2.5
Happiness	1.8	2.2	3.1	1.0	-1.6	-1.8
Medication: Lansoprazole	1.8	2.0	3.4	-1.8	0.4	-1.6
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	5.6	0.7	-1.7	2.4
Birth weight	1.8	4.0	11.8	-0.1	0.3	3.4
Worry too long after embarrassment	1.8	3.0	7.9	2.8	0.1	1.1
Angina (self-reported)	1.8	2.3	5.4	-0.6	2.3	-1.1
Ever had bowel cancer screening	1.8	2.1	3.4	0.6	1.8	1.6
Hearing aid user	1.8	2.0	2.9	1.2	-1.3	1.7
Basal cell carcinoma (self-reported)	1.8	2.1	5.6	0.9	-0.1	2.4
Cardiovascular Disease	1.7	5.8	9.1	-1.0	3.0	-2.7
Medication: Co-codamol	1.7	2.0	2.6	1.6	-1.0	-1.5
Heart attack	1.7	2.2	3.4	1.4	-1.1	-1.8
Commuting to job workplace: Public transport	1.7	2.1	5.3	0.8	2.3	-0.5
Reaction Time	1.6	3.0	4.2	-0.8	2.0	2.0
Body Mass Index (BMI) (2010)	1.6	2.2	3.3	-0.5	-1.8	1.8
Fasting Glucose	1.6	1.9	2.8	1.7	-0.4	-1.6
Bilateral oophorectomy (both ovaries removed)	1.6	1.9	5.0	2.2	-0.1	0.8
Alcohol usually taken with meals	1.6	2.6	6.3	-1.2	-0.1	2.5
Alcohol intake versus 10 years previously	1.6	2.4	4.5	-2.1	0.7	-1.5
Falls in the last year	1.6	2.1	4.9	-2.2	1.1	0.3
Migraine (self-reported)	1.6	2.0	4.7	0.6	0.9	-2.2
Medication: Ibuprofen	1.6	1.9	2.5	1.3	-1.6	-1.3
Fractured/broken bones in last 5 years	1.6	2.0	5.0	-0.9	-2.2	0.7
HbA1C	1.5	1.7	4.2	-0.4	-2.0	0.8
Ulcerative Colitis	1.5	2.1	4.5	-1.2	-0.7	-2.1
Relative age voice broke	1.5	2.3	4.3	1.0	2.1	-1.2
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	4.6	-2.1	0.2	-1.5
Illnesses of mother	1.5	1.8	4.4	1.0	-0.0	2.1
Length of working week for main job	1.5	1.7	2.5	-1.6	-1.5	-0.4
Handedness (chirality/laterality): Left-handed	1.5	1.8	4.6	2.1	0.5	-0.7
Diabetes diagnosed by doctor	1.5	2.4	5.2	0.9	-1.1	-2.3
Alzheimer’s Disease (in father)	1.4	1.5	1.9	-1.4	0.9	-1.3
Lupus	1.4	2.2	3.4	0.7	1.6	-1.8
Type 2 Diabetes (T2D) (2018)	1.4	2.6	5.7	0.5	-1.4	-2.4
Number of treatments/medications taken	1.4	2.6	6.9	0.6	-0.7	-2.6
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	4.0	-2.0	-0.1	1.0
Waist circumference	1.4	5.1	8.0	1.9	-1.9	-2.8
Headache pain in last month	1.4	2.5	6.7	-0.1	0.9	-2.6
Mouth/teeth dental problems: Loose teeth	1.4	1.7	2.6	0.4	-1.6	-1.6
Smoking status: Previous	1.4	2.0	4.0	-1.1	-2.0	0.9
Miserableness	1.4	2.4	3.6	1.8	-0.2	-1.9
Ulcerative Colitis (UC)	1.3	2.4	6.2	-1.0	-0.0	-2.5
Relative age of first facial hair	1.3	2.6	4.4	-0.5	1.8	-2.1
Noisy workplace	1.3	1.7	3.1	0.3	-1.4	-1.8
Medication: Seretide 50 evohaler	1.3	1.5	3.0	1.7	0.3	1.2
Heart disease (mother)	1.3	1.6	2.4	-1.5	1.6	0.3
Heart attack/myocardial infarction (self-reported)	1.3	1.7	2.4	1.2	-1.1	-1.5
Systolic Blood Pressure	1.2	6.2	8.4	-2.9	2.3	2.2
Medication: Metformin	1.2	1.7	2.9	-0.4	-1.5	-1.7
Trunk fat percentage	1.2	4.7	5.4	2.1	-2.1	-2.3
Stomach or abdominal pain in last month	1.2	1.5	4.4	-0.0	2.1	-0.1
Medication: Amlodipine	1.2	1.7	3.4	0.6	1.2	-1.8
Chronic bronchitis/emphysema (mother)	1.2	1.4	4.2	-2.0	0.3	-0.2
Leg fat percentage (right)	1.2	4.3	7.7	1.3	-1.9	-2.8
Supplements: Fish oil (including cod liver oil)	1.2	1.6	3.9	-2.0	-0.5	0.9
Illnesses of father: High blood pressure	1.2	1.5	3.9	2.0	-0.5	-0.5
Average weekly beer plus cider intake	1.2	1.8	3.7	1.9	-1.0	-0.8
Risk taking	1.2	1.8	2.6	-1.6	1.6	0.6
Major Depression (MDD)	1.1	1.3	2.8	1.7	-0.4	-1.0
Coronary Artery Disease (CAD)	1.1	1.3	2.1	-0.3	-1.4	-1.3
Fed-up feelings	1.1	1.9	5.1	-2.3	0.6	-0.5
Supplements: Glucosamine	1.1	1.5	2.8	-0.8	-1.7	1.0
Trunk fat mass	1.1	4.7	5.3	2.0	-2.3	-2.2
Diabetes (self-reported)	1.1	1.7	4.2	0.1	-0.9	-2.1
Father’s age at death	1.1	1.4	1.8	1.3	1.3	1.0
Average weekly red wine intake	1.1	1.7	3.9	0.0	2.0	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	6.6	-2.6	0.6	-0.4
Triglycerides	1.0	1.6	3.8	0.2	1.0	-1.9
Systolic blood pressure, automated reading	1.0	3.0	6.1	-2.5	0.5	1.7
Townsend deprivation index at recruitment	1.0	1.4	2.1	1.5	0.2	-1.4
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	1.7	-1.2	1.0	1.3
Glaucoma (self-reported)	1.0	1.2	1.5	0.8	-1.2	-1.1
Body fat percentage	1.0	4.1	5.9	1.6	-2.0	-2.4
Health satisfaction	1.0	1.3	2.5	0.3	-1.6	-1.1
Pulse rate, automated reading	1.0	3.3	4.7	2.1	-0.9	-2.2
Medication for cholesterol	1.0	1.5	2.3	-0.3	-1.5	1.5
Medication: Gliclazide	1.0	1.1	2.9	-1.7	0.7	-0.1
Guilty feelings	1.0	1.5	3.9	-0.3	0.8	-2.0
Ever taken oral contraceptive pill	1.0	1.1	2.0	-0.7	0.9	1.4
Schizophrenia vs Biploar Disorder	0.9	1.1	2.4	-0.0	1.0	-1.5
Alzheimer’s Disease (including proxy)	0.9	1.3	3.7	-0.4	-0.3	-1.9
Mean Putamen Volume	0.9	1.0	2.1	-0.3	-1.4	0.8
Severe depression (siblings)	0.9	1.0	2.1	1.4	-0.6	-0.8
Taking other prescription medications	0.9	1.4	2.2	1.5	-0.8	-1.1
Past tobacco smoking	0.9	1.6	4.5	0.6	2.1	0.0
Time employed in main current job	0.9	1.0	2.9	-1.7	0.1	-0.4
Worrier / anxious feelings	0.9	1.8	2.4	1.6	1.3	-1.0
Medication: Ventolin 100micrograms inhaler	0.9	1.1	3.2	1.8	-0.1	0.4
Mean time to correctly identify matches	0.9	1.7	2.9	-0.0	1.5	1.7
Whole body fat mass	0.9	3.9	4.8	1.7	-2.0	-2.2
Leg fat mass (right)	0.9	3.7	5.2	1.5	-1.9	-2.3
Had major operations	0.9	1.0	2.4	0.8	-1.5	-0.1
Family relationship satisfaction	0.9	1.1	1.9	-0.1	-1.4	1.2
Qualifications: nursing, teaching	0.9	1.4	1.5	1.2	-1.2	-1.2
Smoking status: Current	0.9	1.4	3.7	0.7	0.0	-1.9
Average weekly champagne plus white wine intake	0.9	1.3	2.2	-1.3	1.5	-0.2
Leg fat percentage (left)	0.9	3.2	5.1	1.0	-1.8	-2.3
Irritability	0.9	1.5	3.7	-0.1	0.9	-1.9
Irritable Bowel Disease (IBD)	0.8	2.0	4.1	-1.3	-0.2	-2.0
Blood Platelet Count	0.8	8.9	21.4	1.2	1.9	-4.6
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.4	0.1	1.6	0.7
Ever used hormone-replacement therapy (HRT)	0.8	1.0	1.8	1.4	-0.9	-0.6
Impedance of leg (right)	0.8	3.6	10.2	-0.0	0.9	-3.2
Current tobacco smoking	0.8	1.3	2.8	1.0	-0.1	-1.7
Chronic bronchitis/emphysema (father)	0.8	1.0	2.2	-0.7	-0.5	-1.5
Allergy	0.8	1.8	4.3	-0.6	-0.9	-2.1
Pain all over the body in last month	0.8	0.8	1.2	-1.1	1.1	0.3
Medication: Ramipril	0.8	1.0	2.8	0.4	0.4	-1.7
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	2.2	0.7	0.5	-1.5
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	2.1	0.9	-1.4	-0.5
Tense / ‘highly strung’	0.8	1.3	2.2	-0.2	1.5	-1.3
Number of children fathered	0.8	0.9	2.0	-1.4	-0.8	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.3	0.3	-0.5	1.5
Illnesses of siblings: Diabetes	0.8	1.0	3.0	-0.3	-0.1	-1.7
Arm fat percentage (left)	0.8	3.2	5.0	1.7	-2.2	-1.3
Vascular/heart problems diagnosed by doctor	0.8	2.1	3.9	1.5	-2.0	0.1
Pain experienced in last month	0.8	1.3	2.5	-0.9	0.8	1.6
Leg fat mass (left)	0.8	3.2	4.4	1.3	-1.8	-2.1
Bipolar Disorder (2018)	0.7	1.0	3.0	-0.4	0.1	1.7
Prostate Cancer	0.7	1.0	1.9	1.4	-1.0	-0.2
Crohns Disease (2012)	0.7	1.1	2.5	-1.6	-1.0	0.1
Blood Red Count	0.7	6.9	18.7	1.4	-0.4	-4.3
Smoking Status	0.7	1.6	3.4	-0.6	-1.8	-1.0
Chronotype (morning person)	0.7	1.5	4.6	-0.2	-2.1	-0.1
Hearing difficulty/problems: Yes	0.7	1.1	3.2	0.3	1.8	0.0
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.6	-0.8	-1.3	-0.4
Arm fat percentage (right)	0.7	2.7	3.7	1.7	-1.9	-1.3
Pulse wave Arterial Stiffness index	0.7	0.8	1.3	-1.1	0.2	-1.1
Arm fat mass (right)	0.7	2.7	3.3	1.8	-1.7	-1.4
Pulse wave peak to peak time	0.7	0.9	1.6	1.3	0.0	1.0
Suffer from ‘nerves’	0.7	1.1	3.4	-1.8	-0.1	0.1
Hypertension (Self-reported)	0.7	1.9	3.8	-1.9	1.4	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.1	0.2	-0.0	1.5
Back pain experienced in last month	0.7	1.0	1.4	0.9	-0.8	-1.2
Arm fat mass (left)	0.7	2.9	4.6	1.7	-2.1	-1.1
Number of self-reported non-cancer illnesses	0.7	1.2	2.0	-0.3	1.3	-1.4
Financial situation satisfaction	0.7	0.8	2.1	-0.1	-1.4	0.6
Eye problems/disorders: Glaucoma	0.7	0.9	2.4	0.1	-1.6	-0.4
Respiratory disease	0.6	1.4	3.9	0.0	-0.4	2.0
Sensitivity / hurt feelings	0.6	1.0	1.6	0.8	0.8	1.3
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.7	-1.3	0.3	-0.3
High blood pressure	0.6	1.6	2.6	-1.6	1.5	0.2
Multivitamins +/- minerals	0.6	0.7	1.9	-1.4	-0.5	0.2
Impedance of leg (left)	0.6	2.7	6.6	-0.4	1.1	-2.6
Fluid intelligence score	0.6	1.3	2.0	0.2	1.4	1.4
Hip circumference	0.6	2.4	5.6	1.3	-2.4	0.1
Prospective memory result	0.6	0.7	1.3	-0.9	0.1	-1.1
Blood clot in the leg (DVT)	0.6	0.8	1.3	1.1	-0.9	0.4
Qualifications: College or University degree	0.6	1.9	4.8	2.2	0.9	0.3
Eye problems/disorders: None of the above	0.6	0.7	1.2	0.8	0.4	-1.1
Medication: Blood pressure	0.6	1.1	2.3	-1.5	0.2	-1.0
Leg pain on walking	0.6	0.7	1.9	-0.1	-1.4	-0.6
Mood swings	0.6	1.0	1.3	1.1	0.8	-1.1
Breast cancer (self-reported)	0.6	0.7	1.6	-0.1	1.2	-0.8
Heart disease (siblings)	0.6	0.8	1.7	-0.1	1.3	0.8
Pack years of smoking	0.6	0.8	1.4	1.0	-1.2	0.2
Alzheimer’s Disease (in mother)	0.5	0.5	1.0	0.3	-0.7	-1.0
Age at First Birth	0.5	0.7	2.0	1.4	0.4	0.2
Blood White Count	0.5	3.8	8.0	-1.7	-0.8	-2.8
Allergy or Eczema	0.5	1.2	2.9	-0.6	0.7	1.7
Hand grip strength (left)	0.5	1.2	1.9	-1.3	-1.4	-0.2
Hayfever, allergic rhinitis or eczema	0.5	1.2	3.2	-0.2	0.4	1.8
Nervous feelings	0.5	0.9	1.8	0.9	0.4	-1.3
Qualifications: None of the above	0.5	1.0	1.6	-1.3	1.0	-0.6
Financial difficulties in last 2 years	0.5	0.7	1.5	-0.4	-0.7	-1.2
Mouth/teeth dental problems	0.5	0.8	2.0	0.1	1.4	0.7
Weight	0.5	2.4	2.9	1.5	-1.7	-1.4
Lung cancer (father)	0.5	0.6	1.0	0.8	-1.0	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.1	-0.4	-0.6	-1.1
Medication: Aspirin	0.5	0.7	1.4	0.7	0.5	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.8	0.1	-0.8	-1.3
Osteoporosis (self-reported)	0.5	0.6	1.2	-0.7	1.1	-0.5
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.3	0.6	-1.1	0.2
Ever smoked	0.5	0.9	2.4	0.2	-1.5	-0.6
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.7	0.1	0.2	1.3
Unable to work because of sickness or disability	0.5	0.7	2.0	0.3	-0.0	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.1	0.8	-1.0	0.6
Depressed Affect (Nagel 2018)	0.4	0.9	1.9	-1.4	-0.8	-0.5
Intelligence (Savage-Jansen 2018)	0.4	1.3	3.2	1.8	0.7	0.4
Rheumatoid Arthritis	0.4	0.6	1.2	-0.2	-0.7	1.1
Hypothyroidism (self reported)	0.4	0.9	1.7	-0.6	1.3	0.8
Average weekly spirits intake	0.4	0.5	0.9	0.1	0.9	0.8
Medication for hormone replacement therapy	0.4	0.4	0.8	-0.2	0.9	-0.7
Hand grip strength (right)	0.4	1.2	2.4	-0.8	-1.5	0.7
Serious illness, injury or assault to yourself	0.4	0.5	0.9	0.8	-0.9	-0.0
Body mass index (BMI)	0.4	1.8	3.7	1.1	-1.9	-0.6
Neuroticism score	0.4	0.8	1.0	1.0	0.9	-0.7
Number of live births	0.4	0.5	0.8	-0.1	-0.9	-0.9
Mouth/teeth dental problems: Dentures	0.4	0.7	1.7	-0.4	-1.3	-0.3
Asthma	0.4	0.7	1.9	0.5	-0.1	1.4
Peak expiratory flow (PEF)	0.4	1.0	1.6	-1.0	-0.7	1.3
Exposure to tobacco smoke outside home	0.4	0.6	1.4	1.2	0.1	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.0	-1.0	0.6	0.3
Age at first live birth	0.4	0.6	1.0	-0.3	1.0	0.9
Emphysema/chronic bronchitis	0.4	0.4	1.1	-0.0	-1.1	0.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.9	-0.5	0.7	0.9
Illnesses of father: None of the above (group 1)	0.4	0.5	1.1	0.2	0.5	1.1
Medication: Paracetamol	0.4	0.6	0.9	0.4	-0.9	-0.9
Medication: Lisinopril	0.4	0.6	1.2	-0.1	0.6	-1.1
Ever depressed for a whole week	0.4	0.4	0.9	0.3	-0.6	-1.0
Myopia	0.4	0.5	1.5	1.2	-0.1	-0.4
Depression (Nagel 2018)	0.3	0.5	1.1	-1.0	-0.6	-0.1
Crohns Disease (2017)	0.3	0.7	0.9	-0.9	-0.8	-0.8
Schizophrenia (2014)	0.3	0.7	2.2	-1.5	0.1	0.1
Blood Eosinophil Count	0.3	2.5	4.1	-2.0	-0.4	1.8
BMI	0.3	2.0	4.7	0.9	-2.2	-0.7
Lung FVC	0.3	1.4	2.2	-1.4	0.1	1.5
Neuroticism	0.3	0.6	1.2	-0.0	1.1	-0.8
Ever had hysterectomy (womb removed)	0.3	0.4	0.7	0.7	-0.8	0.2
Supplements: Zinc	0.3	0.3	0.5	-0.6	0.4	-0.7
Pack years adult smoking proportion	0.3	0.5	0.7	0.8	-0.9	0.1
Leg fat-free mass (left)	0.3	1.3	2.7	1.1	-1.6	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.7	-0.5	0.4	-0.8
Sitting height	0.3	2.2	5.4	1.1	0.3	-2.3
High blood pressure (mother)	0.3	0.4	0.7	-0.2	-0.9	-0.6
Leg predicted mass (left)	0.3	1.4	2.8	1.2	-1.7	0.1
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.7	-0.3	1.3	-0.5
Exposure to tobacco smoke at home	0.3	0.3	0.6	-0.8	-0.3	-0.4
Birth weight of first child	0.3	0.5	1.0	0.5	-1.0	0.6
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.9	-0.2	0.3	1.0
High blood pressure (siblings)	0.3	0.4	0.7	0.6	-0.8	-0.6
Comparative body size at age 10	0.3	0.7	1.3	-0.8	-1.1	0.4
Neck or shoulder pain in last month	0.3	0.4	0.9	-0.3	-0.2	-1.0
Medication: Allopurinol	0.3	0.4	0.6	-0.5	0.8	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.7	-0.4	0.9	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.5	0.7	0.6	-0.3
Eye problems/disorders: Cataract	0.3	0.4	0.5	0.5	0.6	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.8	-0.4	0.9	-0.2
Medication: Aspirin	0.3	0.4	0.7	0.7	-0.1	-0.9
Number of operations (self-reported)	0.3	0.4	0.8	0.7	-0.9	0.1
Commuting to job workplace: Cycle	0.3	0.3	0.4	-0.4	0.6	-0.7
Supplements: Calcium	0.3	0.3	0.6	-0.8	-0.5	0.4
Bipolar Disorder or Schizophrenia	0.2	0.6	1.4	-0.6	-0.0	1.2
Worry (Nagel 2018)	0.2	0.5	1.4	0.1	1.2	0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.8	0.6	-0.4	0.9
Height	0.2	3.0	6.9	1.4	0.6	-2.6
Tanning	0.2	1.9	5.5	0.2	2.3	0.3
Average weekly fortified wine intake	0.2	0.2	0.5	-0.2	0.7	-0.1
Maternal smoking around birth	0.2	0.3	0.6	-0.8	0.5	-0.5
Age when periods started (menarche)	0.2	0.5	1.1	0.3	-0.6	1.0
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	0.2	-0.3	-0.7
Medication: Levothyroxine sodium	0.2	0.4	1.1	-1.0	-0.1	-0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.4	-1.2	-0.0	0.7
Depression (self-reported)	0.2	0.2	0.4	-0.6	0.5	0.1
Loud music exposure frequency	0.2	0.2	0.7	-0.1	0.8	0.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.6	-0.7	0.8	-0.1
Number of full brothers	0.2	0.3	0.4	-0.6	-0.2	-0.6
Shortness of breath walking on level ground	0.2	0.2	0.5	0.2	-0.7	-0.3
Comparative height size at age 10	0.2	1.3	2.6	-1.2	-1.6	-0.1
Age at last live birth	0.2	0.3	0.5	0.2	0.7	0.5
Illnesses of father: Heart disease	0.2	0.2	0.5	0.3	0.7	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.0	0.1	-0.2	1.0
Leg fat-free mass (right)	0.2	1.2	1.9	1.2	-1.4	0.6
Friendships satisfaction	0.2	0.2	0.4	0.6	-0.1	-0.6
Asthma (self-reported)	0.2	0.5	1.1	0.6	0.2	1.0
Leg predicted mass (right)	0.2	1.3	2.2	1.1	-1.5	0.6
Wears glasses or contact lenses	0.2	0.3	0.4	0.4	0.4	-0.7
Mother’s age at death	0.2	0.2	0.5	0.3	-0.7	0.1
Medication: Blood pressure	0.2	0.4	1.0	-0.3	1.0	0.1
Medication: Bendroflumethiazide	0.2	0.3	0.5	0.7	-0.6	0.2
Basal metabolic rate	0.2	0.9	1.6	1.0	-1.3	-0.1
Impedance of whole body	0.2	1.2	3.4	0.3	0.5	-1.8
Ovarian Cancer	0.1	0.2	0.2	-0.5	-0.2	0.5
Primary Biliary Cirrhosis	0.1	0.1	0.3	-0.1	-0.6	0.3
Lung FEV1/FVC ratio	0.1	0.6	0.9	-0.9	-0.9	0.0
Hair Pigment	0.1	2.0	5.4	2.3	-0.6	0.5
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.1	-0.4	-0.0	-0.3
Number of incorrect matches in round	0.1	0.1	0.4	0.1	-0.6	0.0
Had menopause	0.1	0.2	0.3	-0.4	-0.3	0.6
Forced vital capacity (FVC)	0.1	0.5	1.1	-0.6	-0.0	1.1
Illnesses of siblings	0.1	0.1	0.3	0.5	0.0	0.3
Impedance of arm (right)	0.1	0.5	1.1	1.1	-0.0	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	-0.5	-0.1	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.9	-0.9	0.2	0.6
Impedance of arm (left)	0.1	0.5	1.0	1.0	-0.2	-0.5
Standing height	0.1	1.4	2.3	1.4	0.0	-1.5
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.4	-0.2	0.6	0.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.3	0.4	-0.5	-0.3
Medication: Paracetamol	0.1	0.2	0.4	0.6	-0.5	-0.2
Gout (self-reported)	0.1	0.1	0.2	-0.1	0.4	-0.3
Forced vital capacity (FVC), Best measure	0.1	0.5	1.0	-1.0	0.3	0.6
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	-0.0	-0.3	0.4
Overall health rating	0.1	0.2	0.6	-0.8	0.3	-0.3
Chest pain or discomfort	0.1	0.2	0.3	0.6	-0.2	-0.3
Knee pain experienced in last month	0.1	0.2	0.5	0.2	-0.7	0.1
Whole body fat-free mass	0.1	0.5	0.9	0.7	-0.9	0.3
Osteoarthritis (self-reported)	0.1	0.2	0.5	-0.7	0.1	-0.1
Whole body water mass	0.1	0.5	1.1	0.5	-1.1	0.5
Alcohol drinker status: Never	0.1	0.1	0.3	-0.1	-0.6	-0.0
Arm predicted mass (left)	0.1	0.3	0.8	0.4	-0.9	-0.1
Neuroticism (Nagel 2018)	0.0	0.0	0.0	-0.0	0.0	0.1
Schizophrenia (2018)	0.0	0.1	0.2	-0.4	-0.2	0.2
HDL Cholesterol	0.0	0.0	0.1	-0.2	0.1	0.3
Had other major operations	0.0	0.0	0.0	-0.0	-0.1	0.1
Trunk fat-free mass	0.0	0.2	0.2	0.4	-0.5	0.3
Trunk predicted mass	0.0	0.1	0.2	0.4	-0.4	0.2
Arm fat-free mass (right)	0.0	0.2	0.7	-0.0	-0.8	-0.2
Arm predicted mass (right)	0.0	0.2	0.4	0.1	-0.6	-0.3
Long-standing illness, disability or infirmity	0.0	0.0	0.1	0.0	-0.2	0.3
Arm fat-free mass (left)	0.0	0.2	0.3	0.1	-0.6	-0.5
Age started oral contraceptive pill	0.0	0.0	0.1	-0.3	-0.0	0.1

Hub : Genes

PLCG1

Models

Trait associations