Hub : Genes

PLCG1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cortex	0.2420	0.0850	0.00130	0.000	NA	-0.006	NA	0.008	0.310	NA	5.0e-01	NA	0.1900
2	GTEx	Esophagus Mucosa	0.1860	0.0570	0.00037	0.016	NA	0.086	NA	0.029	0.027	NA	2.1e-06	NA	0.0048
3	TCGA	Prostate Adenocarcinoma	0.0281	0.0176	0.00540	0.000	0.02	0.010	NA	0.004	0.290	0.0035	2.6e-02	NA	0.1000

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.7	1.0	3.0	-0.4	0.1	1.7
Bipolar Disorder or Schizophrenia	0.2	0.6	1.4	-0.6	-0.0	1.2
Depressed Affect (Nagel 2018)	0.4	0.9	1.9	-1.4	-0.8	-0.5
Depression (Nagel 2018)	0.3	0.5	1.1	-1.0	-0.6	-0.1
Intelligence (Savage-Jansen 2018)	0.4	1.3	3.2	1.8	0.7	0.4
Neuroticism (Nagel 2018)	0.0	0.0	0.0	-0.0	0.0	0.1
Schizophrenia (2018)	0.0	0.1	0.2	-0.4	-0.2	0.2
Schizophrenia vs Biploar Disorder	0.9	1.1	2.4	-0.0	1.0	-1.5
Worry (Nagel 2018)	0.2	0.5	1.4	0.1	1.2	0.1
Alzheimer’s Disease (in mother)	0.5	0.5	1.0	0.3	-0.7	-1.0
Alzheimer’s Disease (in father)	1.4	1.5	1.9	-1.4	0.9	-1.3
Alzheimer’s Disease (including proxy)	0.9	1.3	3.7	-0.4	-0.3	-1.9
Crohns Disease (2017)	0.3	0.7	0.9	-0.9	-0.8	-0.8
Irritable Bowel Disease (IBD)	0.8	2.0	4.1	-1.3	-0.2	-2.0
Ulcerative Colitis (UC)	1.3	2.4	6.2	-1.0	-0.0	-2.5
Major Depression (MDD)	1.1	1.3	2.8	1.7	-0.4	-1.0
Reaction Time	1.6	3.0	4.2	-0.8	2.0	2.0
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.8	0.6	-0.4	0.9
Breast Cancer	2.0	4.8	5.5	2.3	-2.3	1.9
Ovarian Cancer	0.1	0.2	0.2	-0.5	-0.2	0.5
Prostate Cancer	0.7	1.0	1.9	1.4	-1.0	-0.2
Age at First Birth	0.5	0.7	2.0	1.4	0.4	0.2
Bipolar Disorder (2011)	2.1	2.1	4.5	-0.7	-1.1	2.1
Body Mass Index (BMI) (2010)	1.6	2.2	3.3	-0.5	-1.8	1.8
Coronary Artery Disease (CAD)	1.1	1.3	2.1	-0.3	-1.4	-1.3
Crohns Disease (2012)	0.7	1.1	2.5	-1.6	-1.0	0.1
Mean Putamen Volume	0.9	1.0	2.1	-0.3	-1.4	0.8
Fasting Glucose	1.6	1.9	2.8	1.7	-0.4	-1.6
HbA1C	1.5	1.7	4.2	-0.4	-2.0	0.8
HDL Cholesterol	0.0	0.0	0.1	-0.2	0.1	0.3
LDL Cholesterol	12.0	19.1	47.4	1.9	2.5	-6.9
Lupus	1.4	2.2	3.4	0.7	1.6	-1.8
Neuroticism (2016)	3.9	5.6	15.6	-0.4	1.0	-4.0
Primary Biliary Cirrhosis	0.1	0.1	0.3	-0.1	-0.6	0.3
Rheumatoid Arthritis	0.4	0.6	1.2	-0.2	-0.7	1.1
Schizophrenia (2014)	0.3	0.7	2.2	-1.5	0.1	0.1
Triglycerides	1.0	1.6	3.8	0.2	1.0	-1.9
Type 2 Diabetes (T2D) (2012)	2.9	3.3	6.8	0.7	-1.6	-2.6
Ulcerative Colitis	1.5	2.1	4.5	-1.2	-0.7	-2.1
Blood Eosinophil Count	0.3	2.5	4.1	-2.0	-0.4	1.8
Blood Platelet Count	0.8	8.9	21.4	1.2	1.9	-4.6
Blood Red Count	0.7	6.9	18.7	1.4	-0.4	-4.3
Blood White Count	0.5	3.8	8.0	-1.7	-0.8	-2.8
Heel T-Score	3.7	29.2	85.0	1.3	-0.9	9.2
BMI	0.3	2.0	4.7	0.9	-2.2	-0.7
Height	0.2	3.0	6.9	1.4	0.6	-2.6
Waist Hip Ratio (WHR)	2.8	12.4	35.2	1.4	0.1	-5.9
Systolic Blood Pressure	1.2	6.2	8.4	-2.9	2.3	2.2
Smoking Status	0.7	1.6	3.4	-0.6	-1.8	-1.0
Allergy or Eczema	0.5	1.2	2.9	-0.6	0.7	1.7
Cardiovascular Disease	1.7	5.8	9.1	-1.0	3.0	-2.7
Hypothyroidism (self reported)	0.4	0.9	1.7	-0.6	1.3	0.8
Respiratory disease	0.6	1.4	3.9	0.0	-0.4	2.0
Type 2 Diabetes (T2D) (2018)	1.4	2.6	5.7	0.5	-1.4	-2.4
Lung FEV1/FVC ratio	0.1	0.6	0.9	-0.9	-0.9	0.0
Lung FVC	0.3	1.4	2.2	-1.4	0.1	1.5
Neuroticism	0.3	0.6	1.2	-0.0	1.1	-0.8
Chronotype (morning person)	0.7	1.5	4.6	-0.2	-2.1	-0.1
Hair Pigment	0.1	2.0	5.4	2.3	-0.6	0.5
Tanning	0.2	1.9	5.5	0.2	2.3	0.3
Hand grip strength (left)	0.5	1.2	1.9	-1.3	-1.4	-0.2
Number of treatments/medications taken	1.4	2.6	6.9	0.6	-0.7	-2.6
Average weekly spirits intake	0.4	0.5	0.9	0.1	0.9	0.8
Sensitivity / hurt feelings	0.6	1.0	1.6	0.8	0.8	1.3
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.1	-0.4	-0.0	-0.3
Hearing difficulty/problems: Yes	0.7	1.1	3.2	0.3	1.8	0.0
Relative age of first facial hair	1.3	2.6	4.4	-0.5	1.8	-2.1
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.4	0.1	1.6	0.7
Ever used hormone-replacement therapy (HRT)	0.8	1.0	1.8	1.4	-0.9	-0.6
Ever had hysterectomy (womb removed)	0.3	0.4	0.7	0.7	-0.8	0.2
Systolic blood pressure, automated reading	1.0	3.0	6.1	-2.5	0.5	1.7
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.7	-1.3	0.3	-0.3
Angina	2.0	2.6	6.1	-0.5	2.5	-1.2
Medication for hormone replacement therapy	0.4	0.4	0.8	-0.2	0.9	-0.7
Vitamin and mineral supplements	2.1	2.9	7.5	2.7	1.0	-0.4
Supplements: Zinc	0.3	0.3	0.5	-0.6	0.4	-0.7
Medication: Co-codamol	1.7	2.0	2.6	1.6	-1.0	-1.5
Medication: Metformin	1.2	1.7	2.9	-0.4	-1.5	-1.7
Diabetes (father)	2.8	3.4	5.5	-1.8	-2.3	-1.2
Diabetes (mother)	4.6	5.9	17.5	-0.1	-0.3	-4.2
Severe depression (siblings)	0.9	1.0	2.1	1.4	-0.6	-0.8
Pack years adult smoking proportion	0.3	0.5	0.7	0.8	-0.9	0.1
Impedance of leg (right)	0.8	3.6	10.2	-0.0	0.9	-3.2
Leg fat-free mass (left)	0.3	1.3	2.7	1.1	-1.6	0.1
Trunk fat percentage	1.2	4.7	5.4	2.1	-2.1	-2.3
Hand grip strength (right)	0.4	1.2	2.4	-0.8	-1.5	0.7
Townsend deprivation index at recruitment	1.0	1.4	2.1	1.5	0.2	-1.4
Current tobacco smoking	0.8	1.3	2.8	1.0	-0.1	-1.7
Average weekly fortified wine intake	0.2	0.2	0.5	-0.2	0.7	-0.1
Maternal smoking around birth	0.2	0.3	0.6	-0.8	0.5	-0.5
Fed-up feelings	1.1	1.9	5.1	-2.3	0.6	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.7	-0.5	0.4	-0.8
Relative age voice broke	1.5	2.3	4.3	1.0	2.1	-1.2
Taking other prescription medications	0.9	1.4	2.2	1.5	-0.8	-1.1
Age when periods started (menarche)	0.2	0.5	1.1	0.3	-0.6	1.0
Bilateral oophorectomy (both ovaries removed)	1.6	1.9	5.0	2.2	-0.1	0.8
Heel bone mineral density (BMD) T-score, automated (left)	2.6	5.8	15.5	1.0	-0.9	3.9
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	0.2	-0.3	-0.7
Qualifications: CSEs or equivalent	2.0	2.7	4.2	-1.2	-2.1	1.5
Serious illness, injury or assault to yourself	0.4	0.5	0.9	0.8	-0.9	-0.0
High blood pressure	0.6	1.6	2.6	-1.6	1.5	0.2
Hayfever, allergic rhinitis or eczema	0.5	1.2	3.2	-0.2	0.4	1.8
Multivitamins +/- minerals	0.6	0.7	1.9	-1.4	-0.5	0.2
Stomach or abdominal pain in last month	1.2	1.5	4.4	-0.0	2.1	-0.1
Supplements: Glucosamine	1.1	1.5	2.8	-0.8	-1.7	1.0
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	4.0	-2.0	-0.1	1.0
Medication: Atenolol	3.0	3.7	5.5	-2.4	1.2	-2.1
Medication: Levothyroxine sodium	0.2	0.4	1.1	-1.0	-0.1	-0.4
Sitting height	0.3	2.2	5.4	1.1	0.3	-2.3
Chronic bronchitis/emphysema (father)	0.8	1.0	2.2	-0.7	-0.5	-1.5
High blood pressure (mother)	0.3	0.4	0.7	-0.2	-0.9	-0.6
Body mass index (BMI)	0.4	1.8	3.7	1.1	-1.9	-0.6
Impedance of leg (left)	0.6	2.7	6.6	-0.4	1.1	-2.6
Leg predicted mass (left)	0.3	1.4	2.8	1.2	-1.7	0.1
Trunk fat mass	1.1	4.7	5.3	2.0	-2.3	-2.2
Waist circumference	1.4	5.1	8.0	1.9	-1.9	-2.8
Number of incorrect matches in round	0.1	0.1	0.4	0.1	-0.6	0.0
Past tobacco smoking	0.9	1.6	4.5	0.6	2.1	0.0
Alcohol usually taken with meals	1.6	2.6	6.3	-1.2	-0.1	2.5
Nervous feelings	0.5	0.9	1.8	0.9	0.4	-1.3
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	4.6	-2.1	0.2	-1.5
Hearing difficulty/problems with background noise	2.5	3.9	10.3	-0.6	1.1	3.2
Hair/balding pattern: Pattern 2	3.1	4.0	7.2	2.2	0.2	-2.7
Had menopause	0.1	0.2	0.3	-0.4	-0.3	0.6
Had other major operations	0.0	0.0	0.0	-0.0	-0.1	0.1
Forced vital capacity (FVC)	0.1	0.5	1.1	-0.6	-0.0	1.1
Heel bone mineral density (BMD) T-score, automated (right)	3.0	6.8	18.1	1.5	-0.3	4.3
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.6	-0.8	-1.3	-0.4
Qualifications: None of the above	0.5	1.0	1.6	-1.3	1.0	-0.6
Financial difficulties in last 2 years	0.5	0.7	1.5	-0.4	-0.7	-1.2
Mouth/teeth dental problems	0.5	0.8	2.0	0.1	1.4	0.7
Heart attack	1.7	2.2	3.4	1.4	-1.1	-1.8
Allergy	0.8	1.8	4.3	-0.6	-0.9	-2.1
Pain all over the body in last month	0.8	0.8	1.2	-1.1	1.1	0.3
Diabetes (self-reported)	1.1	1.7	4.2	0.1	-0.9	-2.1
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	1.7	-1.2	1.0	1.3
Medication: Ramipril	0.8	1.0	2.8	0.4	0.4	-1.7
Medication: Simvastatin	4.7	6.9	16.0	1.1	1.9	-4.0
Fluid intelligence score	0.6	1.3	2.0	0.2	1.4	1.4
Illnesses of siblings	0.1	0.1	0.3	0.5	0.0	0.3
Neuroticism score	0.4	0.8	1.0	1.0	0.9	-0.7
Weight	0.5	2.4	2.9	1.5	-1.7	-1.4
Impedance of arm (right)	0.1	0.5	1.1	1.1	-0.0	-0.6
Arm fat percentage (right)	0.7	2.7	3.7	1.7	-1.9	-1.3
Trunk fat-free mass	0.0	0.2	0.2	0.4	-0.5	0.3
Hip circumference	0.6	2.4	5.6	1.3	-2.4	0.1
Time employed in main current job	0.9	1.0	2.9	-1.7	0.1	-0.4
Alcohol intake versus 10 years previously	1.6	2.4	4.5	-2.1	0.7	-1.5
Father’s age at death	1.1	1.4	1.8	1.3	1.3	1.0
Worrier / anxious feelings	0.9	1.8	2.4	1.6	1.3	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	-0.5	-0.1	-0.0
Falls in the last year	1.6	2.1	4.9	-2.2	1.1	0.3
Hair/balding pattern: Pattern 3	4.2	6.2	15.2	-0.0	-1.9	3.9
Number of live births	0.4	0.5	0.8	-0.1	-0.9	-0.9
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.4	-1.2	-0.0	0.7
Pulse rate	2.5	4.2	5.4	2.3	-1.4	-2.3
Happiness	1.8	2.2	3.1	1.0	-1.6	-1.8
Noisy workplace	1.3	1.7	3.1	0.3	-1.4	-1.8
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.7	-0.3	1.3	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	2.2	0.7	0.5	-1.5
Mouth/teeth dental problems: Dentures	0.4	0.7	1.7	-0.4	-1.3	-0.3
Asthma	0.4	0.7	1.9	0.5	-0.1	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	2.1	0.9	-1.4	-0.5
Medication: Cholesterol lowering	3.4	5.2	12.4	1.3	1.3	-3.5
Depression (self-reported)	0.2	0.2	0.4	-0.6	0.5	0.1
Medication: Lansoprazole	1.8	2.0	3.4	-1.8	0.4	-1.6
Prospective memory result	0.6	0.7	1.3	-0.9	0.1	-1.1
Lung cancer (father)	0.5	0.6	1.0	0.8	-1.0	-0.1
Illnesses of mother	1.5	1.8	4.4	1.0	-0.0	2.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.9	-0.9	0.2	0.6
Pulse wave Arterial Stiffness index	0.7	0.8	1.3	-1.1	0.2	-1.1
Impedance of arm (left)	0.1	0.5	1.0	1.0	-0.2	-0.5
Arm fat mass (right)	0.7	2.7	3.3	1.8	-1.7	-1.4
Trunk predicted mass	0.0	0.1	0.2	0.4	-0.4	0.2
Standing height	0.1	1.4	2.3	1.4	0.0	-1.5
Length of working week for main job	1.5	1.7	2.5	-1.6	-1.5	-0.4
Exposure to tobacco smoke at home	0.3	0.3	0.6	-0.8	-0.3	-0.4
Breastfed as a baby	2.1	2.6	3.6	1.3	1.6	1.9
Tense / ‘highly strung’	0.8	1.3	2.2	-0.2	1.5	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	2.2	3.4	8.5	1.2	-0.5	-2.9
Hair/balding pattern: Pattern 4	2.9	6.9	20.6	-0.3	0.3	4.5
Birth weight of first child	0.3	0.5	1.0	0.5	-1.0	0.6
Peak expiratory flow (PEF)	0.4	1.0	1.6	-1.0	-0.7	1.3
Pulse wave reflection index	2.1	2.6	3.5	-1.8	1.0	1.9
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.9	-0.2	0.3	1.0
Loud music exposure frequency	0.2	0.2	0.7	-0.1	0.8	0.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.4	-0.2	0.6	0.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.3	0.4	-0.5	-0.3
Blood clot in the leg (DVT)	0.6	0.8	1.3	1.1	-0.9	0.4
Medication: Paracetamol	0.1	0.2	0.4	0.6	-0.5	-0.2
Headache pain in last month	1.4	2.5	6.7	-0.1	0.9	-2.6
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	5.6	0.7	-1.7	2.4
Glaucoma (self-reported)	1.0	1.2	1.5	0.8	-1.2	-1.1
Gout (self-reported)	0.1	0.1	0.2	-0.1	0.4	-0.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.6	-0.7	0.8	-0.1
Medication: Amlodipine	1.2	1.7	3.4	0.6	1.2	-1.8
Medication: Ventolin 100micrograms inhaler	0.9	1.1	3.2	1.8	-0.1	0.4
Birth weight	1.8	4.0	11.8	-0.1	0.3	3.4
Chronic bronchitis/emphysema (mother)	1.2	1.4	4.2	-2.0	0.3	-0.2
High blood pressure (siblings)	0.3	0.4	0.7	0.6	-0.8	-0.6
Forced vital capacity (FVC), Best measure	0.1	0.5	1.0	-1.0	0.3	0.6
Body fat percentage	1.0	4.1	5.9	1.6	-2.0	-2.4
Leg fat percentage (right)	1.2	4.3	7.7	1.3	-1.9	-2.8
Arm fat-free mass (right)	0.0	0.2	0.7	-0.0	-0.8	-0.2
Exposure to tobacco smoke outside home	0.4	0.6	1.4	1.2	0.1	0.6
Comparative body size at age 10	0.3	0.7	1.3	-0.8	-1.1	0.4
Number of full brothers	0.2	0.3	0.4	-0.6	-0.2	-0.6
Worry too long after embarrassment	1.8	3.0	7.9	2.8	0.1	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.0	-1.0	0.6	0.3
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	-0.0	-0.3	0.4
Number of children fathered	0.8	0.9	2.0	-1.4	-0.8	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.3	0.3	-0.5	1.5
Age at first live birth	0.4	0.6	1.0	-0.3	1.0	0.9
Pulse wave peak to peak time	0.7	0.9	1.6	1.3	0.0	1.0
Health satisfaction	1.0	1.3	2.5	0.3	-1.6	-1.1
Shortness of breath walking on level ground	0.2	0.2	0.5	0.2	-0.7	-0.3
Qualifications: College or University degree	0.6	1.9	4.8	2.2	0.9	0.3
Eye problems/disorders: None of the above	0.6	0.7	1.2	0.8	0.4	-1.1
Mouth/teeth dental problems: Loose teeth	1.4	1.7	2.6	0.4	-1.6	-1.6
Emphysema/chronic bronchitis	0.4	0.4	1.1	-0.0	-1.1	0.2
Medication for pain relief, constipation, heartburn	2.1	3.6	5.4	-2.3	0.7	2.2
Neck or shoulder pain in last month	0.3	0.4	0.9	-0.3	-0.2	-1.0
Medication: Blood pressure	0.6	1.1	2.3	-1.5	0.2	-1.0
Angina (self-reported)	1.8	2.3	5.4	-0.6	2.3	-1.1
Migraine (self-reported)	1.6	2.0	4.7	0.6	0.9	-2.2
Medication: Ibuprofen	1.6	1.9	2.5	1.3	-1.6	-1.3
Medication: Allopurinol	0.3	0.4	0.6	-0.5	0.8	-0.5
Medication: Omeprazole	2.8	3.3	9.3	3.0	-0.8	-0.3
Medication: Seretide 50 evohaler	1.3	1.5	3.0	1.7	0.3	1.2
Mean time to correctly identify matches	0.9	1.7	2.9	-0.0	1.5	1.7
Heart disease (mother)	1.3	1.6	2.4	-1.5	1.6	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.7	-0.4	0.9	-0.0
Whole body fat mass	0.9	3.9	4.8	1.7	-2.0	-2.2
Leg fat mass (right)	0.9	3.7	5.2	1.5	-1.9	-2.3
Arm predicted mass (right)	0.0	0.2	0.4	0.1	-0.6	-0.3
Pulse rate, automated reading	1.0	3.3	4.7	2.1	-0.9	-2.2
Alcohol intake frequency.	2.4	5.5	13.3	-1.8	-0.2	-3.6
Comparative height size at age 10	0.2	1.3	2.6	-1.2	-1.6	-0.1
Number of full sisters	2.5	3.0	5.3	-2.3	1.8	0.9
Suffer from ‘nerves’	0.7	1.1	3.4	-1.8	-0.1	0.1
Overall health rating	0.1	0.2	0.6	-0.8	0.3	-0.3
Chest pain or discomfort	0.1	0.2	0.3	0.6	-0.2	-0.3
Had major operations	0.9	1.0	2.4	0.8	-1.5	-0.1
Age at last live birth	0.2	0.3	0.5	0.2	0.7	0.5
Family relationship satisfaction	0.9	1.1	1.9	-0.1	-1.4	1.2
Leg pain on walking	0.6	0.7	1.9	-0.1	-1.4	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.1	-0.4	-0.6	-1.1
Commuting to job workplace: Car/motor vehicle	2.8	3.2	6.8	-1.0	-2.6	1.3
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.9	-0.5	0.7	0.9
Medication: Aspirin	0.5	0.7	1.4	0.7	0.5	-1.2
Supplements: Vitamin C	2.6	3.1	5.5	-1.7	-2.3	0.9
Knee pain experienced in last month	0.1	0.2	0.5	0.2	-0.7	0.1
Hypertension (Self-reported)	0.7	1.9	3.8	-1.9	1.4	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.5	0.7	0.6	-0.3
Illnesses of father: Heart disease	0.2	0.2	0.5	0.3	0.7	-0.2
Illnesses of siblings: Diabetes	0.8	1.0	3.0	-0.3	-0.1	-1.7
Smoking status: Previous	1.4	2.0	4.0	-1.1	-2.0	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.0	0.1	-0.2	1.0
Whole body fat-free mass	0.1	0.5	0.9	0.7	-0.9	0.3
Leg fat-free mass (right)	0.2	1.2	1.9	1.2	-1.4	0.6
Arm fat percentage (left)	0.8	3.2	5.0	1.7	-2.2	-1.3
Average weekly red wine intake	1.1	1.7	3.9	0.0	2.0	1.0
Handedness (chirality/laterality): Left-handed	1.5	1.8	4.6	2.1	0.5	-0.7
Mood swings	0.6	1.0	1.3	1.1	0.8	-1.1
Loneliness, isolation	2.0	2.8	8.1	-0.4	-2.9	-0.2
Long-standing illness, disability or infirmity	0.0	0.0	0.1	0.0	-0.2	0.3
Ever had bowel cancer screening	1.8	2.1	3.4	0.6	1.8	1.6
Diabetes diagnosed by doctor	1.5	2.4	5.2	0.9	-1.1	-2.3
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.1	0.2	-0.0	1.5
Friendships satisfaction	0.2	0.2	0.4	0.6	-0.1	-0.6
Qualifications: nursing, teaching	0.9	1.4	1.5	1.2	-1.2	-1.2
Commuting to job workplace: Walk	2.2	2.4	3.5	1.9	1.6	-1.1
Eye problems/disorders: Cataract	0.3	0.4	0.5	0.5	0.6	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.8	0.1	-0.8	-1.3
Medication for cholesterol	1.0	1.5	2.3	-0.3	-1.5	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.8	-0.4	0.9	-0.2
Back pain experienced in last month	0.7	1.0	1.4	0.9	-0.8	-1.2
Mineral and other dietary supplements	2.0	2.8	4.5	1.5	1.2	-2.1
Breast cancer (self-reported)	0.6	0.7	1.6	-0.1	1.2	-0.8
Asthma (self-reported)	0.2	0.5	1.1	0.6	0.2	1.0
Osteoporosis (self-reported)	0.5	0.6	1.2	-0.7	1.1	-0.5
Osteoarthritis (self-reported)	0.1	0.2	0.5	-0.7	0.1	-0.1
Medication: Aspirin	0.3	0.4	0.7	0.7	-0.1	-0.9
Medication: Gliclazide	1.0	1.1	2.9	-1.7	0.7	-0.1
Illnesses of father: None of the above (group 1)	0.4	0.5	1.1	0.2	0.5	1.1
Smoking status: Current	0.9	1.4	3.7	0.7	0.0	-1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	6.6	-2.6	0.6	-0.4
Whole body water mass	0.1	0.5	1.1	0.5	-1.1	0.5
Leg predicted mass (right)	0.2	1.3	2.2	1.1	-1.5	0.6
Arm fat mass (left)	0.7	2.9	4.6	1.7	-2.1	-1.1
Number of self-reported non-cancer illnesses	0.7	1.2	2.0	-0.3	1.3	-1.4
Average weekly champagne plus white wine intake	0.9	1.3	2.2	-1.3	1.5	-0.2
Miserableness	1.4	2.4	3.6	1.8	-0.2	-1.9
Guilty feelings	1.0	1.5	3.9	-0.3	0.8	-2.0
Wears glasses or contact lenses	0.2	0.3	0.4	0.4	0.4	-0.7
Ever taken oral contraceptive pill	1.0	1.1	2.0	-0.7	0.9	1.4
Hearing aid user	1.8	2.0	2.9	1.2	-1.3	1.7
Mother’s age at death	0.2	0.2	0.5	0.3	-0.7	0.1
Financial situation satisfaction	0.7	0.8	2.1	-0.1	-1.4	0.6
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.3	0.6	-1.1	0.2
Commuting to job workplace: Public transport	1.7	2.1	5.3	0.8	2.3	-0.5
Eye problems/disorders: Glaucoma	0.7	0.9	2.4	0.1	-1.6	-0.4
Medication: Blood pressure	0.2	0.4	1.0	-0.3	1.0	0.1
Pain type(s) experienced in last month: Hip pain	2.3	2.9	4.5	-1.3	-1.6	-2.1
Supplements: Fish oil (including cod liver oil)	1.2	1.6	3.9	-2.0	-0.5	0.9
High cholesterol (Self-reported)	5.5	9.7	19.5	1.7	2.6	-4.4
Medication: Bendroflumethiazide	0.2	0.3	0.5	0.7	-0.6	0.2
Medication: Paracetamol	0.4	0.6	0.9	0.4	-0.9	-0.9
Medication: Lisinopril	0.4	0.6	1.2	-0.1	0.6	-1.1
Medication: Atorvastatin	2.5	3.1	5.3	2.3	0.6	-1.9
Illnesses of father: High blood pressure	1.2	1.5	3.9	2.0	-0.5	-0.5
Alcohol drinker status: Never	0.1	0.1	0.3	-0.1	-0.6	-0.0
Ever smoked	0.5	0.9	2.4	0.2	-1.5	-0.6
Basal metabolic rate	0.2	0.9	1.6	1.0	-1.3	-0.1
Leg fat percentage (left)	0.9	3.2	5.1	1.0	-1.8	-2.3
Arm fat-free mass (left)	0.0	0.2	0.3	0.1	-0.6	-0.5
Number of operations (self-reported)	0.3	0.4	0.8	0.7	-0.9	0.1
Average weekly beer plus cider intake	1.2	1.8	3.7	1.9	-1.0	-0.8
Irritability	0.9	1.5	3.7	-0.1	0.9	-1.9
Risk taking	1.2	1.8	2.6	-1.6	1.6	0.6
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.7	0.1	0.2	1.3
Fractured/broken bones in last 5 years	1.6	2.0	5.0	-0.9	-2.2	0.7
Age started oral contraceptive pill	0.0	0.0	0.1	-0.3	-0.0	0.1
Diastolic blood pressure, automated reading	1.9	5.8	15.3	-1.0	1.0	3.9
Ever depressed for a whole week	0.4	0.4	0.9	0.3	-0.6	-1.0
Unable to work because of sickness or disability	0.5	0.7	2.0	0.3	-0.0	-1.4
Commuting to job workplace: Cycle	0.3	0.3	0.4	-0.4	0.6	-0.7
Myopia	0.4	0.5	1.5	1.2	-0.1	-0.4
Vascular/heart problems diagnosed by doctor	0.8	2.1	3.9	1.5	-2.0	0.1
Cholesterol lowering medication	4.0	5.9	12.2	0.7	2.2	-3.5
Medication: Omeprazole (e.g. Zanprol)	3.4	4.1	11.1	3.3	-1.1	0.2
Pain experienced in last month	0.8	1.3	2.5	-0.9	0.8	1.6
Supplements: Calcium	0.3	0.3	0.6	-0.8	-0.5	0.4
Basal cell carcinoma (self-reported)	1.8	2.1	5.6	0.9	-0.1	2.4
Heart attack/myocardial infarction (self-reported)	1.3	1.7	2.4	1.2	-1.1	-1.5
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.1	0.8	-1.0	0.6
Heart disease (siblings)	0.6	0.8	1.7	-0.1	1.3	0.8
Alcohol drinker status: Previous	1.9	2.1	6.2	0.4	0.1	-2.5
Pack years of smoking	0.6	0.8	1.4	1.0	-1.2	0.2
Impedance of whole body	0.2	1.2	3.4	0.3	0.5	-1.8
Leg fat mass (left)	0.8	3.2	4.4	1.3	-1.8	-2.1
Arm predicted mass (left)	0.1	0.3	0.8	0.4	-0.9	-0.1