Hub : Genes

EYA2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.417	0.0670	7.0e-11	0.325	NA	0.322	NA	0.341	1.6e-18	NA	2.7e-18	NA	1.6e-19
2	GTEx	Spleen	0.308	0.1000	8.4e-03	0.047	NA	0.092	NA	0.057	2.4e-02	NA	2.4e-03	NA	1.4e-02
3	GTEx	Thyroid	0.286	0.0510	4.4e-09	0.159	NA	0.152	NA	0.142	3.3e-12	NA	1.0e-11	NA	5.6e-11
4	METSIM	Adipose	0.051	0.0187	1.2e-03	0.012	0.024	0.026	0.022	0.020	4.6e-03	1.5e-04	6.6e-05	0.00025	4.4e-04
5	TCGA	Thyroid Carcinoma	0.361	0.0510	0.0e+00	0.141	0.241	0.284	NA	0.272	1.2e-13	3.1e-23	9.0e-28	NA	1.5e-26

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.4	0.6	0.9	-0.2	0.9	0.8	-0.8	1.0
Bipolar Disorder or Schizophrenia	0.3	0.8	2.8	-0.7	1.7	0.8	-0.1	0.4
Depressed Affect (Nagel 2018)	0.8	1.7	5.0	2.2	-1.6	-0.1	1.0	0.1
Depression (Nagel 2018)	0.1	0.2	0.4	0.4	-0.6	-0.4	-0.0	-0.6
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.5	0.7	0.4	-0.5	0.4	0.3
Neuroticism (Nagel 2018)	0.8	2.0	5.1	2.3	-1.7	-0.2	1.2	-0.3
Schizophrenia (2018)	0.4	0.8	3.0	-0.7	1.7	0.3	0.5	-0.2
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	-0.0	0.4	0.6	-0.5	0.8
Worry (Nagel 2018)	0.2	0.4	1.9	1.4	-0.5	0.1	0.1	0.1
Alzheimer’s Disease (in mother)	0.4	0.5	1.7	-0.2	-0.7	0.4	-1.3	0.4
Alzheimer’s Disease (in father)	0.1	0.1	0.1	0.3	-0.3	0.4	-0.1	0.2
Alzheimer’s Disease (including proxy)	0.5	0.8	1.9	0.6	-0.2	1.4	0.0	1.3
Crohns Disease (2017)	0.8	1.7	4.5	2.1	0.0	-0.9	1.6	-0.8
Irritable Bowel Disease (IBD)	0.8	1.8	6.8	2.6	-1.0	0.3	0.8	0.8
Ulcerative Colitis (UC)	1.0	1.8	4.8	2.2	-1.0	1.1	0.0	1.5
Major Depression (MDD)	0.9	1.1	3.6	-0.3	1.9	-0.2	-1.3	-0.3
Reaction Time	0.4	0.8	2.6	-0.6	-1.6	-1.0	-0.0	-0.3
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.7	1.0	1.3	-0.3	1.1	-0.1
Breast Cancer	0.3	0.8	2.2	-0.7	0.8	0.6	1.5	0.2
Ovarian Cancer	0.5	0.7	1.8	-0.0	-0.0	-1.3	-0.0	-1.3
Prostate Cancer	0.5	0.8	1.4	-0.7	-0.2	-1.0	-0.9	-1.2
Age at First Birth	0.4	0.6	1.9	1.0	-1.4	0.4	-0.1	0.4
Bipolar Disorder (2011)	0.5	0.5	0.7	0.7	0.9	-0.2	-0.7	-0.8
Body Mass Index (BMI) (2010)	2.1	2.9	5.0	-1.3	0.8	-2.2	-1.6	-2.1
Coronary Artery Disease (CAD)	3.3	4.0	13.9	3.7	0.7	1.1	2.0	0.5
Crohns Disease (2012)	0.5	0.8	2.5	1.6	-0.1	-0.2	1.2	0.3
Mean Putamen Volume	0.5	0.5	1.6	0.9	1.2	0.1	0.5	-0.3
Fasting Glucose	0.6	0.7	1.7	1.3	0.6	-0.2	1.1	-0.6
HbA1C	0.6	0.7	1.3	-0.6	0.4	-1.1	-0.5	-1.2
HDL Cholesterol	0.6	1.0	2.2	-0.3	-1.3	-1.5	-0.4	1.0
LDL Cholesterol	0.2	0.4	1.5	0.2	0.2	0.4	0.3	-1.2
Lupus	0.8	1.3	2.4	1.0	1.5	-1.1	-0.8	-1.0
Neuroticism (2016)	0.6	0.8	2.2	0.1	0.2	-1.5	0.0	-1.3
Primary Biliary Cirrhosis	0.3	0.5	1.2	0.1	-0.0	0.8	0.7	1.1
Rheumatoid Arthritis	2.6	3.6	11.8	0.1	-0.5	-1.9	-3.4	-1.6
Schizophrenia (2014)	0.3	0.6	2.0	-0.7	1.4	-0.2	-0.3	-0.6
Triglycerides	4.0	6.6	14.9	2.1	1.1	3.9	3.5	0.6
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.5	0.7	-1.5	0.8	1.6	-0.2
Ulcerative Colitis	0.6	0.9	2.4	1.6	-0.8	0.6	-0.5	0.9
Blood Eosinophil Count	0.3	2.5	8.6	0.9	0.2	0.8	2.9	1.5
Blood Platelet Count	0.2	2.0	8.6	0.1	2.9	0.7	-1.0	-0.1
Blood Red Count	0.6	5.3	15.1	0.4	-3.9	2.5	1.0	2.0
Blood White Count	0.3	2.1	6.3	-0.9	-0.1	-1.1	-2.5	-1.5
Heel T-Score	10.8	85.6	163.8	-8.4	-1.3	-12.8	-9.2	-10.3
BMI	1.0	6.0	10.2	-2.7	-0.7	-3.0	-3.2	-1.7
Height	0.4	8.3	16.5	-3.1	3.8	-0.1	-4.1	-1.1
Waist Hip Ratio (WHR)	18.8	84.6	201.9	11.9	-1.2	6.5	14.2	5.9
Systolic Blood Pressure	0.9	4.4	10.6	3.3	1.4	1.9	2.4	0.4
Smoking Status	0.2	0.5	1.4	-0.7	-0.2	0.5	1.2	0.6
Allergy or Eczema	1.7	4.4	7.5	2.7	2.1	1.2	2.4	1.7
Cardiovascular Disease	1.0	3.4	11.5	1.9	-0.9	1.0	3.4	0.0
Hypothyroidism (self reported)	0.2	0.4	1.5	1.2	0.4	-0.1	-0.4	-0.4
Respiratory disease	0.5	1.1	4.0	0.8	2.0	-0.6	0.4	0.3
Type 2 Diabetes (T2D) (2018)	3.5	6.6	24.2	2.3	0.4	1.8	4.9	-0.7
Lung FEV1/FVC ratio	0.6	3.1	6.9	2.6	-1.3	1.4	1.9	1.1
Lung FVC	5.7	29.0	49.7	-7.0	2.1	-5.3	-5.3	-6.0
Neuroticism	0.3	0.7	3.0	1.7	-0.3	-0.2	0.6	-0.1
Chronotype (morning person)	0.3	0.7	2.3	1.5	-0.6	-0.1	-0.4	0.8
Hair Pigment	0.0	0.9	1.6	-0.5	-0.1	-1.0	-1.2	-1.3
Tanning	0.1	1.7	5.5	-2.3	-0.4	0.4	-1.0	1.4
Hand grip strength (left)	0.9	2.3	6.2	0.2	1.8	2.5	0.4	1.4
Number of treatments/medications taken	0.8	1.4	2.6	1.6	1.1	1.0	1.5	-0.1
Average weekly spirits intake	0.6	0.7	1.1	-1.0	0.6	0.8	-0.7	0.9
Sensitivity / hurt feelings	0.7	1.1	3.2	1.0	-1.2	0.0	1.8	-0.4
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.4	0.5	0.2	0.6	0.2	0.1
Hearing difficulty/problems: Yes	1.5	2.3	4.3	-1.7	-1.1	-1.7	0.1	-2.1
Relative age of first facial hair	0.2	0.5	0.7	-0.8	0.6	0.8	-0.7	-0.3
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.5	0.7	1.1	0.5	-0.3	1.2
Ever used hormone-replacement therapy (HRT)	0.5	0.6	0.9	0.7	-1.0	-0.1	-0.8	1.0
Ever had hysterectomy (womb removed)	0.2	0.2	0.7	-0.3	-0.2	-0.2	-0.8	-0.1
Systolic blood pressure, automated reading	0.3	0.7	2.4	1.6	0.3	0.2	1.1	0.0
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	4.0	1.6	-0.3	0.2	2.0	-0.7
Angina	0.6	0.8	2.2	0.9	0.2	1.0	1.5	0.3
Medication for hormone replacement therapy	0.1	0.1	0.2	0.5	0.0	-0.2	-0.2	0.0
Vitamin and mineral supplements	1.5	2.1	5.2	-0.4	0.8	-1.9	-2.3	-0.7
Supplements: Zinc	2.1	2.3	4.9	-1.3	0.8	-1.3	-2.2	-1.6
Medication: Co-codamol	1.3	1.5	5.2	-0.4	2.3	-0.8	-0.3	-1.1
Medication: Metformin	3.2	4.5	19.1	0.5	-0.5	1.6	4.4	-0.1
Diabetes (father)	2.6	3.2	8.3	0.9	0.7	2.9	2.3	1.0
Diabetes (mother)	2.5	3.2	9.3	2.0	-1.6	0.5	3.0	-0.4
Severe depression (siblings)	0.6	0.7	1.5	0.7	-0.8	-0.7	-1.2	-0.5
Pack years adult smoking proportion	0.2	0.3	0.7	-0.8	-0.0	-0.4	0.8	0.3
Impedance of leg (right)	0.1	0.4	1.5	1.2	-0.1	-0.5	-0.1	-0.6
Leg fat-free mass (left)	0.5	2.5	4.7	-2.1	1.6	-0.3	-2.2	-0.8
Trunk fat percentage	2.1	8.3	22.1	-1.3	1.0	-3.1	-4.7	-2.7
Hand grip strength (right)	1.2	3.3	7.1	-0.2	2.7	2.6	-0.6	1.5
Townsend deprivation index at recruitment	0.2	0.3	0.7	0.5	0.7	0.4	0.3	0.8
Current tobacco smoking	0.9	1.5	4.2	-2.1	-1.3	0.1	-1.1	-0.0
Average weekly fortified wine intake	1.3	1.5	4.4	-2.1	-0.5	-0.1	-1.1	-1.3
Maternal smoking around birth	0.2	0.3	0.6	-0.8	-0.6	0.7	-0.5	0.0
Fed-up feelings	0.4	0.7	1.7	1.3	0.9	-0.1	0.8	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.5	-0.6	-0.8	-1.2	-0.3	-1.2
Relative age voice broke	0.3	0.5	1.4	-1.2	0.0	-0.2	-0.7	-0.7
Taking other prescription medications	1.3	2.0	4.8	2.2	1.6	1.3	0.8	0.4
Age when periods started (menarche)	0.1	0.4	0.8	-0.7	-0.6	0.2	-0.2	0.9
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.5	-0.1	0.7	-0.5	-1.2	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	6.5	14.7	24.1	-4.0	0.2	-4.9	-3.9	-4.2
Tinnitus: Yes, but not now, but have in the past	4.7	5.0	9.3	-2.3	-0.5	-3.0	-1.2	-3.1
Qualifications: CSEs or equivalent	0.3	0.3	1.5	-0.2	-1.2	0.4	0.0	0.2
Serious illness, injury or assault to yourself	1.3	1.6	5.3	2.3	1.1	0.9	0.3	0.7
High blood pressure	1.8	4.9	13.4	2.7	-1.4	1.2	3.7	0.5
Hayfever, allergic rhinitis or eczema	0.8	1.7	6.3	1.1	2.5	0.4	0.8	0.2
Multivitamins +/- minerals	0.5	0.6	1.4	0.4	-1.0	0.8	1.2	0.0
Stomach or abdominal pain in last month	2.3	2.9	5.6	2.4	1.2	2.0	1.7	0.4
Supplements: Glucosamine	0.7	1.0	2.5	0.5	1.6	0.8	0.1	1.2
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.7	1.0	-0.2	0.2	1.7	-1.1
Medication: Atenolol	1.5	1.8	3.3	1.4	0.7	1.6	1.8	0.9
Medication: Levothyroxine sodium	0.5	0.8	3.2	1.8	0.6	0.4	0.4	-0.3
Sitting height	3.1	22.3	42.8	-5.6	5.1	-1.2	-6.5	-3.1
Chronic bronchitis/emphysema (father)	0.8	0.9	3.2	-0.4	-0.2	-1.0	-1.8	-0.4
High blood pressure (mother)	0.5	0.7	1.3	-0.4	0.9	1.1	0.8	0.8
Body mass index (BMI)	1.2	5.3	11.3	-2.4	0.1	-2.4	-3.4	-1.8
Impedance of leg (left)	0.1	0.5	1.7	1.3	0.1	-0.6	-0.2	-0.7
Leg predicted mass (left)	0.5	2.7	5.0	-2.2	1.7	-0.3	-2.2	-0.8
Trunk fat mass	2.0	8.6	20.9	-2.1	1.4	-2.8	-4.6	-2.7
Waist circumference	0.1	0.4	1.0	0.6	-0.1	-1.0	-0.8	-0.1
Number of incorrect matches in round	1.0	1.6	7.4	0.4	-2.7	0.0	0.7	0.4
Past tobacco smoking	0.4	0.8	3.6	-0.5	0.1	0.1	-1.9	0.3
Alcohol usually taken with meals	0.9	1.4	2.4	1.2	0.8	1.4	1.6	0.9
Nervous feelings	0.2	0.4	0.9	0.8	-0.2	-0.4	1.0	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	0.9	-0.3	-0.9	0.8	1.0	-0.8
Hearing difficulty/problems with background noise	0.3	0.5	2.3	-1.5	0.0	-0.4	-0.0	-0.4
Hair/balding pattern: Pattern 2	0.8	1.0	2.5	-0.3	-1.6	-0.2	0.6	-1.4
Had menopause	1.2	1.5	2.4	-1.2	-1.3	-1.3	-1.6	0.4
Had other major operations	2.0	2.5	4.2	-1.4	-2.0	-1.9	-1.3	-1.0
Forced vital capacity (FVC)	3.8	14.6	28.2	-5.3	3.4	-2.4	-4.0	-3.4
Heel bone mineral density (BMD) T-score, automated (right)	5.0	11.4	21.8	-3.5	-0.3	-4.7	-3.4	-3.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.2	-0.1	0.3	-0.8	0.0	-1.5
Qualifications: None of the above	0.4	0.9	3.3	-0.7	-0.7	-0.1	-1.8	-0.0
Financial difficulties in last 2 years	1.4	1.9	3.9	2.0	-0.1	1.8	1.2	1.1
Mouth/teeth dental problems	0.5	0.8	2.8	-1.2	0.0	-0.0	-1.7	0.1
Heart attack	0.5	0.6	1.5	1.2	0.2	0.9	-0.3	0.6
Allergy	1.0	2.3	6.2	-1.6	-2.5	0.4	-1.5	-0.3
Pain all over the body in last month	1.6	1.7	4.0	0.1	2.0	0.1	-1.7	1.3
Diabetes (self-reported)	2.7	4.1	10.7	1.7	-0.3	2.6	3.3	0.4
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.5	-1.1	1.1	-1.6	0.1	-0.9
Medication: Ramipril	0.3	0.4	1.1	0.8	0.2	0.2	1.1	0.6
Medication: Simvastatin	1.3	1.9	5.2	0.2	-0.2	1.9	2.3	0.7
Fluid intelligence score	0.7	1.4	3.4	1.7	-0.7	-0.1	1.9	0.0
Illnesses of siblings	1.9	2.7	6.4	-0.3	2.1	-1.3	-2.5	-1.1
Neuroticism score	0.3	0.5	1.5	1.2	-0.5	-0.0	0.9	0.1
Weight	1.4	7.0	15.8	-3.1	1.5	-1.9	-4.0	-2.0
Impedance of arm (right)	0.3	1.2	4.7	2.2	0.0	-0.7	-1.0	-0.1
Arm fat percentage (right)	1.9	7.4	19.2	-1.9	0.0	-3.1	-4.4	-2.1
Trunk fat-free mass	0.5	3.0	9.5	-3.1	1.4	-0.0	-1.7	-0.5
Hip circumference	6.8	29.3	82.6	-5.6	0.7	-4.6	-9.1	-3.3
Time employed in main current job	1.8	2.1	2.9	1.5	1.2	1.6	1.2	1.7
Alcohol intake versus 10 years previously	0.9	1.3	2.0	1.4	-1.2	1.2	1.1	0.6
Father’s age at death	0.3	0.4	1.3	0.5	1.1	0.3	-0.2	0.6
Worrier / anxious feelings	0.1	0.3	0.6	0.1	-0.5	0.8	0.6	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.0	-0.1	-1.0	0.1	-0.3	-0.8
Falls in the last year	0.3	0.4	1.0	1.0	0.1	-0.1	0.2	0.9
Hair/balding pattern: Pattern 3	1.0	1.5	2.9	0.2	1.7	1.2	-1.1	1.3
Number of live births	0.2	0.3	0.5	-0.7	-0.7	-0.5	0.2	0.2
Forced expiratory volume in 1-second (FEV1)	3.1	10.6	18.6	-4.3	2.8	-2.3	-3.3	-3.2
Pulse rate	0.7	1.1	2.6	-0.2	-0.3	1.6	0.6	1.6
Happiness	2.3	2.8	7.1	2.7	0.7	-0.9	1.1	-2.1
Noisy workplace	0.3	0.4	1.1	-0.5	-0.2	0.7	1.0	0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.4	0.6	0.5	0.3	0.1	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.1	-0.7	-0.2	1.4	-0.1	0.3
Mouth/teeth dental problems: Dentures	0.8	1.4	2.4	-0.7	-1.5	-1.2	0.3	-1.5
Asthma	0.5	0.9	2.7	1.6	1.1	-0.5	0.8	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	3.5	0.1	1.9	0.5	1.1	-0.3
Medication: Cholesterol lowering	0.9	1.5	2.9	0.2	1.4	1.5	1.7	0.3
Depression (self-reported)	1.2	1.5	3.4	-0.9	0.8	-1.9	-1.1	-1.2
Medication: Lansoprazole	0.6	0.7	2.1	1.4	0.8	-0.6	0.4	-0.3
Prospective memory result	2.2	2.7	4.6	-2.1	-1.9	-0.8	-2.1	0.1
Lung cancer (father)	0.1	0.1	0.2	0.4	-0.2	-0.4	0.0	0.1
Illnesses of mother	0.1	0.2	0.8	-0.3	-0.1	-0.0	0.1	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	2.3	7.5	13.7	-3.7	2.1	-1.4	-3.0	-2.9
Pulse wave Arterial Stiffness index	1.2	1.4	4.6	2.2	-0.6	-0.0	1.3	-0.0
Impedance of arm (left)	0.4	1.8	7.6	2.8	0.1	-0.5	-0.7	-0.6
Arm fat mass (right)	1.9	7.8	20.4	-2.5	0.7	-2.7	-4.5	-2.1
Trunk predicted mass	0.5	3.0	9.7	-3.1	1.4	-0.1	-1.7	-0.6
Standing height	0.4	3.7	11.4	-1.7	3.4	1.2	-1.6	-0.4
Length of working week for main job	0.6	0.7	2.1	1.4	-0.2	0.2	-1.0	0.5
Exposure to tobacco smoke at home	1.7	1.9	4.8	1.0	-0.6	-2.2	1.3	-1.3
Breastfed as a baby	0.5	0.6	0.9	-0.9	0.4	1.0	0.9	0.4
Tense / ‘highly strung’	0.5	0.9	1.5	1.2	1.0	0.4	1.2	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.9	-0.1	-0.5	-0.2	0.8	-0.9
Hair/balding pattern: Pattern 4	3.7	8.9	16.6	2.5	2.4	3.1	2.4	4.1
Birth weight of first child	0.6	1.0	2.3	1.4	-0.6	0.6	1.5	-0.5
Peak expiratory flow (PEF)	1.8	4.1	6.8	-2.6	2.2	-1.2	-2.1	-1.7
Pulse wave reflection index	0.5	0.6	1.0	1.0	-0.7	0.8	0.8	0.2
Ever highly irritable/argumentative for 2 days	3.5	4.1	11.2	-0.7	0.7	-2.8	-0.9	-3.4
Loud music exposure frequency	0.2	0.2	0.3	-0.4	0.5	-0.6	-0.3	-0.5
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.5	0.3	0.7	0.1	0.4	-0.3
Mouth/teeth dental problems: Bleeding gums	2.3	2.9	5.4	2.3	1.7	1.0	1.9	1.4
Blood clot in the leg (DVT)	0.2	0.2	0.5	-0.7	-0.7	-0.4	0.3	-0.2
Medication: Paracetamol	0.4	0.7	2.3	1.5	0.1	0.5	-0.8	-0.5
Headache pain in last month	0.5	0.9	3.7	1.9	0.4	0.7	0.1	-0.3
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.2	-0.2	-0.9	-1.0	-1.5	0.0
Glaucoma (self-reported)	0.6	0.7	1.3	-1.2	-0.8	0.6	0.2	-1.1
Gout (self-reported)	0.1	0.1	0.3	-0.4	-0.2	0.1	0.2	-0.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.9	1.4	0.9	0.2	-0.4	-0.6
Medication: Amlodipine	1.6	2.3	6.9	1.9	-0.5	-0.6	2.6	0.0
Medication: Ventolin 100micrograms inhaler	0.6	0.7	2.4	0.9	0.1	-1.5	0.0	-0.6
Birth weight	0.1	0.1	0.3	0.1	0.4	-0.0	-0.4	0.5
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.8	0.7	-0.8	-0.8	-0.0	0.9
High blood pressure (siblings)	1.2	1.8	6.2	1.2	-0.7	0.5	2.5	0.7
Forced vital capacity (FVC), Best measure	3.3	12.2	23.8	-4.9	2.4	-2.1	-3.9	-3.5
Body fat percentage	2.2	8.7	22.4	-1.6	0.6	-3.3	-4.7	-2.7
Leg fat percentage (right)	2.5	8.9	17.4	-2.7	-0.3	-3.6	-4.2	-2.5
Arm fat-free mass (right)	0.5	2.8	6.1	-2.5	1.8	-0.2	-1.9	-1.0
Exposure to tobacco smoke outside home	0.6	0.9	1.9	-0.8	0.5	-1.2	-0.4	-1.4
Comparative body size at age 10	2.3	6.3	11.0	-3.3	1.1	-3.0	-2.2	-2.3
Number of full brothers	0.2	0.3	0.6	-0.3	-0.2	-0.6	-0.8	0.5
Worry too long after embarrassment	1.0	1.7	7.3	0.0	-2.7	-0.5	1.0	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.4	-0.0	1.2	0.0	0.9	0.5
Wheeze or whistling in the chest in last year	0.3	0.5	1.1	0.4	-1.1	-0.8	0.5	-0.6
Number of children fathered	0.5	0.5	1.2	0.8	1.1	0.6	-0.0	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	1.3	-1.2	-0.7	-0.9	-0.3	-0.0
Age at first live birth	0.2	0.3	0.7	-0.3	-0.5	-0.9	0.1	-0.7
Pulse wave peak to peak time	1.3	1.5	4.5	-2.1	1.1	0.3	-1.3	0.1
Health satisfaction	0.6	0.8	2.0	1.4	0.2	-0.6	-0.3	-1.3
Shortness of breath walking on level ground	0.3	0.4	1.5	1.2	0.3	0.3	0.0	0.7
Qualifications: College or University degree	0.4	1.2	3.1	1.0	0.7	1.2	1.8	0.3
Eye problems/disorders: None of the above	0.3	0.4	0.9	1.0	-0.6	-0.2	0.7	-0.1
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.4	0.1	0.7	1.5	1.5	1.0
Emphysema/chronic bronchitis	2.4	2.7	9.0	1.0	-0.9	1.0	1.3	3.0
Medication for pain relief, constipation, heartburn	1.1	1.8	3.9	-2.0	-0.9	-1.8	-1.1	0.1
Neck or shoulder pain in last month	0.2	0.2	0.6	0.5	-0.2	0.5	0.8	0.1
Medication: Blood pressure	0.8	1.4	4.5	1.0	0.3	1.0	2.1	0.5
Angina (self-reported)	0.5	0.7	1.7	1.0	0.4	0.8	1.3	-0.0
Migraine (self-reported)	0.8	0.9	3.2	1.8	0.2	0.4	1.1	-0.3
Medication: Ibuprofen	1.3	1.6	5.3	1.1	2.3	0.1	1.1	0.0
Medication: Allopurinol	0.5	0.6	1.8	-0.2	0.8	1.4	0.8	-0.0
Medication: Omeprazole	0.6	0.7	2.0	0.5	0.7	1.4	0.2	0.8
Medication: Seretide 50 evohaler	0.4	0.4	1.7	0.5	-1.3	-0.3	-0.1	0.1
Mean time to correctly identify matches	0.5	1.0	2.3	-0.1	-1.5	-1.4	-0.4	-0.5
Heart disease (mother)	0.6	0.7	2.3	1.5	0.6	0.2	0.8	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	3.6	1.0	-0.8	-0.2	1.9	0.5
Whole body fat mass	2.1	8.9	22.8	-2.4	1.1	-2.9	-4.8	-2.6
Leg fat mass (right)	2.1	8.2	16.1	-2.8	0.7	-3.0	-4.0	-2.7
Arm predicted mass (right)	0.5	2.8	7.3	-2.7	1.7	-0.1	-1.7	-0.9
Pulse rate, automated reading	0.8	2.7	6.7	0.6	1.2	2.6	1.2	1.8
Alcohol intake frequency.	1.1	2.5	7.2	2.7	-0.7	0.9	2.0	0.4
Comparative height size at age 10	0.2	1.4	5.0	0.4	2.2	0.9	0.9	-0.2
Number of full sisters	0.2	0.2	0.8	-0.9	-0.5	-0.4	-0.0	-0.0
Suffer from ‘nerves’	0.1	0.1	0.4	-0.2	0.1	0.5	0.6	-0.1
Overall health rating	0.6	1.4	3.1	1.8	0.2	-0.9	0.3	-1.7
Chest pain or discomfort	1.2	1.8	3.2	1.0	0.6	1.8	1.4	1.5
Had major operations	1.6	1.9	5.0	0.8	-0.3	1.3	1.5	2.2
Age at last live birth	0.1	0.1	0.4	0.5	0.1	-0.7	0.0	0.1
Family relationship satisfaction	0.7	0.9	1.5	1.2	-0.4	-0.9	0.9	-1.1
Leg pain on walking	0.4	0.5	1.4	-0.9	-0.1	-1.2	-0.2	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.1	1.5	1.3	0.7	0.9	0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.6	-0.3	-0.4	-0.8	-0.2	-0.6
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	3.3	-1.8	-0.6	-0.9	0.2	-1.5
Medication: Aspirin	2.1	2.7	6.0	1.3	0.0	2.4	2.4	0.7
Supplements: Vitamin C	0.7	0.9	2.4	0.3	0.9	0.9	1.5	-0.2
Knee pain experienced in last month	0.3	0.5	1.9	0.0	-0.3	-0.5	-1.4	-0.4
Hypertension (Self-reported)	1.3	3.6	11.9	2.1	-1.2	0.5	3.4	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.5	1.1	0.6	-0.7	-0.6	-1.2
Illnesses of father: Heart disease	0.6	0.9	1.5	1.1	-0.6	0.6	1.0	1.2
Illnesses of siblings: Diabetes	1.3	1.6	4.9	-0.9	-0.8	0.3	2.2	-1.4
Smoking status: Previous	1.1	1.6	5.5	1.1	1.1	0.2	2.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	5.1	-1.2	2.3	0.9	0.2	-1.1
Whole body fat-free mass	0.5	3.0	7.3	-2.7	1.7	-0.2	-2.0	-0.7
Leg fat-free mass (right)	0.4	2.4	4.2	-2.0	1.8	-0.1	-2.1	-0.7
Arm fat percentage (left)	1.7	6.8	17.8	-1.6	0.1	-3.0	-4.2	-2.2
Average weekly red wine intake	0.7	1.1	2.6	-0.0	-0.8	-1.6	-1.2	-0.9
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.4	-0.2	1.2	-0.1	-0.4	1.2
Mood swings	1.9	3.4	6.5	2.5	-1.3	1.5	2.2	1.3
Loneliness, isolation	0.2	0.3	0.5	0.7	-0.7	-0.1	0.6	0.5
Long-standing illness, disability or infirmity	0.9	1.4	2.5	1.6	1.0	1.0	1.5	-0.3
Ever had bowel cancer screening	1.9	2.2	5.4	-0.5	-0.1	-2.3	-1.9	-1.3
Diabetes diagnosed by doctor	2.9	4.7	16.2	1.4	-0.3	2.3	4.0	0.0
Ever had stillbirth, spontaneous miscarriage or termination	2.8	3.0	9.5	-0.8	0.2	-3.1	-0.3	-2.2
Friendships satisfaction	0.7	0.9	3.4	1.9	-0.4	-0.3	0.8	-0.1
Qualifications: nursing, teaching	1.5	2.3	6.4	2.5	0.2	1.5	0.8	1.4
Commuting to job workplace: Walk	1.3	1.4	3.6	0.8	-1.3	1.9	0.3	0.9
Eye problems/disorders: Cataract	0.4	0.5	1.1	0.3	0.4	-1.1	-1.0	-0.2
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	6.4	2.5	1.1	1.3	1.3	1.0
Medication for cholesterol	1.6	2.4	7.0	-1.9	0.8	-0.6	-2.7	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	1.7	1.3	-1.1	-1.0	0.9	-0.8
Back pain experienced in last month	1.7	2.5	6.6	-0.9	0.7	-1.5	-2.6	-1.6
Mineral and other dietary supplements	0.2	0.3	0.7	-0.1	0.1	-0.8	0.5	-0.7
Breast cancer (self-reported)	0.3	0.4	0.9	0.5	1.0	-0.6	-0.4	0.6
Asthma (self-reported)	0.3	0.7	1.4	1.2	1.2	-0.7	0.1	0.0
Osteoporosis (self-reported)	0.9	1.1	4.4	2.1	-0.1	0.6	0.2	0.8
Osteoarthritis (self-reported)	0.6	0.8	3.1	1.8	-0.1	-0.2	1.0	0.4
Medication: Aspirin	2.7	3.5	7.5	1.7	0.1	2.7	2.5	1.0
Medication: Gliclazide	1.3	1.4	5.2	1.0	-0.6	0.7	2.3	-0.5
Illnesses of father: None of the above (group 1)	0.7	0.9	1.5	-0.6	0.3	-1.1	-1.2	-1.2
Smoking status: Current	1.2	1.8	5.4	-2.3	-1.3	0.1	-1.5	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.2	6.8	12.1	-2.2	1.0	-2.7	-2.9	-3.5
Whole body water mass	0.5	2.9	7.6	-2.8	1.6	-0.3	-2.0	-0.8
Leg predicted mass (right)	0.5	2.4	4.3	-2.1	1.8	-0.0	-2.0	-0.7
Arm fat mass (left)	1.9	7.9	20.3	-2.6	0.7	-2.7	-4.5	-2.2
Number of self-reported non-cancer illnesses	1.4	2.5	9.4	3.1	-0.1	0.0	1.7	-0.2
Average weekly champagne plus white wine intake	0.2	0.2	0.5	-0.6	0.5	0.7	0.0	0.2
Miserableness	0.2	0.4	1.0	0.5	0.1	1.0	0.7	0.6
Guilty feelings	0.2	0.4	1.0	-0.1	-1.0	-0.3	-0.3	-0.7
Wears glasses or contact lenses	0.8	1.0	2.7	1.6	-0.6	0.0	-1.3	-0.3
Ever taken oral contraceptive pill	0.3	0.3	0.7	-0.7	0.2	0.9	0.3	0.3
Hearing aid user	1.6	1.8	4.7	-2.2	0.3	-1.0	-1.7	-0.6
Mother’s age at death	2.8	3.5	10.0	-0.6	-0.6	-2.4	-3.2	-1.0
Financial situation satisfaction	1.0	1.3	4.5	1.2	2.1	0.3	-0.0	0.4
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.2	-0.3	-0.1	0.7	-0.1	1.1
Commuting to job workplace: Public transport	1.2	1.4	4.1	2.0	0.7	0.6	1.5	0.2
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	-0.6	-1.0	0.6	0.7	0.3
Medication: Blood pressure	0.6	1.2	3.5	1.3	-0.4	0.7	1.9	0.1
Pain type(s) experienced in last month: Hip pain	2.0	2.5	7.4	-1.0	-0.5	-1.5	-2.7	-1.2
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.5	-0.4	0.0	0.5	-0.7	0.7
High cholesterol (Self-reported)	0.2	0.4	1.1	-0.3	0.5	0.8	1.0	-0.2
Medication: Bendroflumethiazide	0.1	0.2	0.7	0.9	-0.1	0.6	0.0	0.0
Medication: Paracetamol	0.6	1.0	3.5	1.9	-0.1	-0.3	-0.9	-0.8
Medication: Lisinopril	0.7	1.0	1.7	1.1	1.0	0.8	0.5	-1.3
Medication: Atorvastatin	0.5	0.6	1.4	-0.4	1.2	0.6	1.0	-0.0
Illnesses of father: High blood pressure	0.4	0.5	1.7	-0.7	1.3	-0.0	0.3	-0.2
Alcohol drinker status: Never	0.3	0.3	1.0	0.3	1.0	0.4	0.3	0.6
Ever smoked	0.6	1.0	2.9	0.1	-1.0	-0.4	1.7	-0.9
Basal metabolic rate	0.7	3.8	8.2	-2.9	1.8	-0.5	-2.5	-1.0
Leg fat percentage (left)	2.2	8.0	16.8	-2.5	-0.2	-3.3	-4.1	-2.4
Arm fat-free mass (left)	0.8	4.1	10.8	-3.3	1.6	-0.7	-2.4	-1.0
Number of operations (self-reported)	0.6	1.0	1.6	-0.1	-1.3	0.7	1.3	1.0
Average weekly beer plus cider intake	0.1	0.1	0.3	-0.5	0.3	-0.1	0.3	0.5
Irritability	0.6	1.0	2.8	1.4	-0.2	-0.5	1.7	-0.1
Risk taking	0.2	0.3	0.7	-0.5	-0.6	-0.6	-0.8	-0.2
Ever had prostate specific antigen (PSA) test	1.4	1.6	2.3	-1.0	-1.1	-1.5	-1.4	-1.1
Fractured/broken bones in last 5 years	2.1	2.7	5.8	2.4	-0.3	2.2	0.1	1.7
Age started oral contraceptive pill	0.4	0.5	0.7	0.8	0.8	-0.8	-0.2	-0.6
Diastolic blood pressure, automated reading	0.7	2.0	4.5	1.8	2.1	1.1	0.9	0.7
Ever depressed for a whole week	0.7	0.9	2.4	0.7	0.3	-0.6	1.0	-1.6
Unable to work because of sickness or disability	0.3	0.4	0.8	-0.2	0.8	0.9	0.0	0.7
Commuting to job workplace: Cycle	0.6	0.8	3.2	0.1	0.7	0.3	1.8	-0.2
Myopia	0.7	1.1	1.7	1.3	-0.4	-1.2	-0.6	-1.3
Vascular/heart problems diagnosed by doctor	1.5	4.0	10.2	-2.4	1.3	-1.2	-3.2	-0.9
Cholesterol lowering medication	2.1	3.1	9.8	0.6	-0.5	1.8	3.1	1.4
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.9	0.5	1.0	1.7	-0.5	0.8
Pain experienced in last month	0.9	1.6	3.1	-1.4	-1.7	-0.2	1.3	1.1
Supplements: Calcium	1.1	1.2	2.5	1.6	-1.1	0.9	1.2	0.4
Basal cell carcinoma (self-reported)	0.3	0.3	1.5	-0.1	1.2	0.3	-0.3	0.0
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.7	1.3	0.3	0.7	-0.3	0.0
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.8	-0.8	-0.9	-0.7	-0.0	-0.7
Heart disease (siblings)	0.7	0.8	3.2	0.7	-1.8	0.3	-0.4	0.5
Alcohol drinker status: Previous	0.3	0.3	0.9	0.9	-0.4	0.6	0.5	0.4
Pack years of smoking	0.2	0.3	0.6	-0.8	0.0	-0.5	0.6	0.4
Impedance of whole body	0.3	1.3	5.3	2.3	0.4	-0.6	-0.4	-0.7
Leg fat mass (left)	1.9	7.4	15.4	-2.7	0.7	-2.8	-3.9	-2.5
Arm predicted mass (left)	0.7	3.7	9.7	-3.1	2.0	-0.4	-2.1	-0.6