Best TWAS P=6.19e-17 · Best GWAS P=3.33e-22 conditioned to 2.51e-18
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ACTR2 | 0.06 | 0.04 | lasso | 3 | 0.04 | 5.3e-06 | 5.8 | -5.5 | 4.3e-08 | -0.05 | 0.00 | 0.99 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | ARHGAP25 | 0.27 | 0.27 | bslmm | 586 | 0.33 | 5.5e-41 | -7.0 | 8.4 | 6.2e-17 | -0.06 | 0.00 | 1.00 | TRUE |
| 3 | CommonMind | Brain Pre-frontal Cortex | MEIS1 | 0.21 | 0.11 | bslmm | 539 | 0.12 | 5.5e-15 | -4.8 | -5.7 | 1.3e-08 | -0.52 | 0.79 | 0.21 | TRUE |
| 4 | GTEx | Adipose Subcutaneous | ACTR2 | 0.17 | 0.09 | lasso | 4 | 0.09 | 1.1e-07 | 5.8 | -5.2 | 2.4e-07 | -0.02 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Artery Tibial | ACTR2 | 0.17 | 0.07 | enet | 17 | 0.07 | 2.9e-06 | 5.8 | -5.2 | 2.0e-07 | -0.04 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Nerve Tibial | ETAA1 | 0.18 | 0.01 | enet | 43 | 0.04 | 9.0e-04 | -2.6 | 5.6 | 2.6e-08 | 0.01 | 0.25 | 0.08 | TRUE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | ACTR2 | 0.21 | 0.10 | lasso | 6 | 0.08 | 3.4e-05 | 5.7 | -5.4 | 7.8e-08 | -0.05 | 0.00 | 0.99 | FALSE |
| 8 | METSIM | Adipose | SERTAD2 | 0.06 | 0.04 | lasso | 2 | 0.03 | 5.0e-06 | 6.6 | 6.3 | 2.3e-10 | -0.08 | 0.01 | 0.99 | TRUE |
| 9 | NTR | Blood | SERTAD2 | 0.04 | 0.02 | lasso | 4 | 0.04 | 9.5e-12 | -7.1 | 5.7 | 9.8e-09 | -0.01 | 0.00 | 1.00 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | ACTR2 | 0.17 | 0.14 | lasso | 5 | 0.14 | 1.4e-17 | 5.8 | -5.3 | 1.4e-07 | -0.05 | 0.00 | 1.00 | FALSE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | ARHGAP25 | 0.33 | 0.19 | bslmm | 573 | 0.24 | 5.2e-30 | -7.0 | 7.3 | 3.8e-13 | -0.03 | 0.00 | 1.00 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ACTR2 | 0.09 | 0.08 | enet | 4 | 0.09 | 3.1e-10 | 5.8 | -5.4 | 5.7e-08 | -0.03 | 0.00 | 1.00 | FALSE |
| 13 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ARHGAP25 | 0.10 | 0.00 | blup | 173 | 0.04 | 8.2e-04 | 5.3 | -5.3 | 1.3e-07 | -0.01 | 0.06 | 0.06 | FALSE |