TWAS hub - SERTAD2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0634	0.0276	8.1e-03	0.039	0.006	0.026	0.022	0.035	1.6e-06	3.9e-02	8.3e-05	2.7e-04	5.0e-06
2	NTR	Blood	0.0358	0.0112	1.5e-05	0.017	0.017	0.034	0.030	0.036	3.2e-06	1.9e-06	3.3e-11	5.0e-10	9.5e-12
3	YFS	Blood	0.0269	0.0107	1.4e-03	0.007	0.012	0.010	0.014	0.005	2.3e-03	5.2e-05	2.2e-04	1.3e-05	6.1e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Lung FEV1/FVC ratio	8.4	42.5	52.0	7.2	7.0	5.1
Heel bone mineral density (BMD) T-score, automated (left)	7.9	18.0	34.2	4.4	5.8	0.3
Osteoporosis (self-reported)	7.9	9.8	17.9	-4.2	-2.2	-2.6
Heel bone mineral density (BMD) T-score, automated (right)	7.0	16.0	27.7	4.5	5.3	-0.1
Pulse rate	5.6	9.4	14.6	-3.6	-3.8	0.6
Cholesterol lowering medication	3.9	5.8	12.3	-2.1	-3.5	0.9
Pulse rate, automated reading	3.8	12.3	26.8	-3.2	-5.2	-0.1
Supplements: Fish oil (including cod liver oil)	3.7	4.8	9.7	-3.1	-2.1	-0.2
Medication: Bendroflumethiazide	3.4	5.2	13.5	0.3	1.4	3.7
Supplements: Vitamin C	3.2	3.8	6.8	0.4	2.1	2.6
Vascular/heart problems diagnosed by doctor	3.2	8.7	24.2	-0.1	-1.4	-4.9
Heel T-Score	3.1	24.8	40.2	6.3	5.7	1.2
Comparative body size at age 10	3.1	8.6	18.1	4.3	1.7	2.2
Medication: Blood pressure	3.0	5.3	12.0	-0.8	1.8	3.5
Hair/balding pattern: Pattern 3	2.9	4.3	10.0	0.3	3.2	1.7
Heart attack/myocardial infarction (self-reported)	2.9	3.8	10.7	-0.5	0.7	3.3
Eye problems/disorders: Cataract	2.7	3.2	7.0	-2.6	-1.5	-0.4
Type 2 Diabetes (T2D) (2012)	2.6	3.0	5.5	0.7	1.8	2.3
Leg pain on walking	2.6	3.3	7.9	-2.8	-1.3	-0.4
Fractured/broken bones in last 5 years	2.6	3.3	6.2	-1.5	-1.3	-2.5
Alzheimer’s Disease (in mother)	2.5	3.0	8.1	0.8	0.4	2.8
Mean Putamen Volume	2.5	2.9	5.5	2.3	1.2	-1.3
Asthma	2.5	5.0	8.3	-1.6	-2.9	-2.0
Heart attack	2.4	3.0	8.5	-0.5	0.6	2.9
Blood Red Count	2.3	21.9	47.2	-3.7	-6.9	-2.1
High blood pressure	2.3	6.3	18.2	-0.5	0.7	4.3
Happiness	2.2	2.7	5.0	-2.2	-1.6	-0.6
Mouth/teeth dental problems: Dentures	2.2	3.7	8.7	-2.9	-1.6	0.0
Pulse wave reflection index	2.2	2.7	7.0	1.0	2.6	-0.2
Shortness of breath walking on level ground	2.2	2.6	5.6	-2.4	-0.5	1.4
Hypertension (Self-reported)	2.2	6.0	17.8	-0.3	0.4	4.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.2	2.6	7.0	-0.8	-0.3	2.6
Number of self-reported non-cancer illnesses	2.2	3.8	7.8	-1.8	-0.6	2.8
Respiratory disease	2.1	4.6	6.2	-2.4	-2.5	-1.2
Ever had hysterectomy (womb removed)	2.1	2.4	5.4	-2.3	-1.1	-0.6
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	2.9	1.7	1.4	1.6
Had other major operations	2.1	2.6	4.5	-2.1	-0.6	1.7
Medication: Ibuprofen	2.1	2.5	4.0	-0.2	-2.0	-1.9
Mineral and other dietary supplements	2.1	2.9	6.6	2.6	1.3	0.5
Asthma (self-reported)	2.1	4.1	6.6	-1.4	-2.6	-1.9
Number of operations (self-reported)	2.1	3.1	7.7	-2.8	0.2	1.3
Lung FVC	2.0	10.1	15.8	-0.8	-4.0	-3.7
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.5	5.3	-0.4	-1.4	-2.3
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	4.7	-1.2	-2.2	-1.0
Smoking status: Previous	2.0	3.0	5.9	1.8	2.4	0.1
Prostate Cancer	1.9	2.7	5.1	-1.3	1.1	-2.3
Illnesses of mother	1.9	2.3	6.8	-0.4	0.0	-2.6
Hypothyroidism/myxoedema (self-reported)	1.9	3.6	6.2	1.9	2.5	1.0
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	4.8	-2.2	-1.1	-0.5
Peak expiratory flow (PEF)	1.8	4.2	5.1	2.0	2.3	1.9
Number of full sisters	1.8	2.2	3.3	1.8	-1.6	0.9
Illnesses of siblings: Diabetes	1.8	2.2	4.3	-0.8	-2.1	1.3
Relative age voice broke	1.7	2.6	6.5	-2.6	-0.7	-0.9
Hearing difficulty/problems with background noise	1.7	2.8	3.9	1.7	1.2	2.0
Medication for cholesterol, blood pressure or diabetes	1.7	2.8	6.4	0.9	-1.0	-2.5
Migraine (self-reported)	1.7	2.1	4.1	-1.4	-0.6	-2.0
Long-standing illness, disability or infirmity	1.7	2.6	7.7	-0.3	-0.4	2.8
Commuting to job workplace: Walk	1.7	1.8	2.8	0.6	1.5	1.7
Cardiovascular Disease	1.6	5.1	14.6	-0.9	0.1	3.8
Hair/balding pattern: Pattern 4	1.6	3.9	9.9	3.1	0.7	1.2
Ever highly irritable/argumentative for 2 days	1.6	1.9	3.1	-1.8	-1.6	-0.1
Medication: Omeprazole	1.6	1.9	3.6	-1.3	-0.6	1.9
High cholesterol (Self-reported)	1.6	2.8	3.7	-1.9	-1.9	1.0
Lupus	1.5	2.3	4.4	-2.1	-1.1	1.2
Average weekly spirits intake	1.5	1.9	2.7	-0.8	-1.7	-1.5
Hearing difficulty/problems: Yes	1.5	2.2	6.0	0.4	0.7	2.4
Diabetes (father)	1.5	1.9	2.9	-1.7	-1.4	1.0
Medication: Atenolol	1.5	1.9	3.6	-1.9	-0.7	-1.2
Health satisfaction	1.5	2.0	2.5	-1.5	-1.6	1.1
Mouth/teeth dental problems: Loose teeth	1.5	1.8	4.2	1.1	2.0	0.2
Angina (self-reported)	1.5	2.0	2.8	1.1	1.4	1.7
LDL Cholesterol	1.4	2.2	5.3	-0.2	-1.1	-2.3
Neuroticism (2016)	1.4	2.0	4.0	-2.0	-1.4	-0.2
Medication: Lansoprazole	1.4	1.6	4.0	-2.0	0.2	0.9
Breastfed as a baby	1.4	1.8	3.0	1.7	1.0	1.1
Medication: Aspirin	1.4	1.9	4.8	-0.5	0.8	2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.7	2.4	-1.5	-0.7	1.5
Illnesses of father: Heart disease	1.4	2.0	5.3	-0.7	0.3	2.3
Medication: Blood pressure	1.4	2.7	7.3	-0.1	-0.9	2.7
Medication: Lisinopril	1.4	1.8	5.0	0.1	0.7	2.2
Bipolar Disorder (2011)	1.3	1.3	3.6	0.0	1.9	-0.6
Rheumatoid Arthritis	1.3	1.8	3.6	0.8	1.1	1.9
Number of treatments/medications taken	1.3	2.3	3.5	-1.8	0.1	1.9
Severe depression (siblings)	1.3	1.4	3.3	1.8	0.7	-0.8
Hair/balding pattern: Pattern 2	1.3	1.7	2.4	-0.8	-1.5	-1.4
Chest pain or discomfort	1.3	1.8	3.6	-1.9	-1.2	0.7
Knee pain experienced in last month	1.3	2.1	3.9	-2.0	0.7	-1.4
Loneliness, isolation	1.3	1.8	4.0	-0.3	-2.0	-1.2
Friendships satisfaction	1.3	1.7	3.0	-0.0	-1.4	-1.7
Hearing aid user	1.3	1.5	4.2	-0.3	2.1	-0.2
Risk taking	1.3	1.9	3.8	0.8	-1.2	-1.9
Hypothyroidism (self reported)	1.2	2.8	5.4	2.3	1.6	0.6
Mouth/teeth dental problems	1.2	1.8	4.8	2.2	0.7	0.2
Depression (self-reported)	1.2	1.5	4.2	0.5	-0.3	2.0
Lung cancer (father)	1.2	1.5	3.7	-0.7	-1.9	0.5
Medication: Aspirin	1.2	1.6	3.6	-0.4	1.0	1.9
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.5	-0.9	1.9	0.2
Commuting to job workplace: Cycle	1.2	1.5	3.1	-1.0	-0.6	-1.8
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	4.1	-0.4	0.2	2.0
Pack years of smoking	1.2	1.7	2.4	-0.9	-1.4	1.6
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	3.6	-0.8	-0.0	1.9
Pack years adult smoking proportion	1.1	1.7	2.7	-0.9	-1.6	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.6	4.9	2.2	2.2	-1.1
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	4.0	-0.6	-2.0	-0.9
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.1	1.1	0.9	1.4
Miserableness	1.1	1.9	3.9	-1.2	-2.0	0.5
Guilty feelings	1.1	1.6	2.4	-0.6	-1.4	-1.6
Medication: Atorvastatin	1.1	1.3	2.3	-1.5	0.8	1.0
Alzheimer’s Disease (including proxy)	1.0	1.4	2.4	1.0	0.9	1.5
Breast Cancer	1.0	2.4	2.9	1.7	1.7	1.2
Ovarian Cancer	1.0	1.3	3.9	-0.1	0.1	-2.0
HDL Cholesterol	1.0	1.7	4.5	-0.8	-2.1	-0.2
Primary Biliary Cirrhosis	1.0	1.4	1.6	-1.2	-1.0	1.3
Relative age of first facial hair	1.0	2.0	3.8	-1.9	-0.5	-1.3
Systolic blood pressure, automated reading	1.0	2.9	8.1	0.2	-0.7	2.8
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	1.9	-1.4	-1.0	1.0
Time employed in main current job	1.0	1.1	2.2	-0.6	-1.5	-0.9
Medication: Cholesterol lowering	1.0	1.6	4.0	-0.9	-0.1	2.0
Exposure to tobacco smoke at home	1.0	1.1	1.6	-0.5	-1.2	-1.3
Birth weight of first child	1.0	1.8	4.0	-2.0	-1.1	-0.4
Glaucoma (self-reported)	1.0	1.1	2.8	0.3	0.7	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	1.7	1.3	1.3	0.5
Commuting to job workplace: Car/motor vehicle	1.0	1.1	1.8	-1.2	-0.4	-1.4
Wears glasses or contact lenses	1.0	1.1	2.4	-0.1	1.5	1.0
Commuting to job workplace: Public transport	1.0	1.2	2.9	0.7	-0.6	1.7
Alcohol drinker status: Never	1.0	1.2	1.7	1.2	-1.3	0.8
Average weekly beer plus cider intake	1.0	1.5	3.2	1.0	-0.5	-1.8
Age started oral contraceptive pill	1.0	1.3	2.3	-1.5	-1.0	0.7
Verbal and Numeric Reasoning (VNR)	0.9	2.1	4.1	0.4	2.0	1.4
Blood Platelet Count	0.9	10.4	23.8	-2.5	-4.9	1.1
Systolic Blood Pressure	0.9	4.7	11.4	0.9	-1.4	3.4
Supplements: Zinc	0.9	1.0	1.7	1.3	1.1	0.2
Current tobacco smoking	0.9	1.5	3.4	-0.9	-1.9	0.6
Qualifications: CSEs or equivalent	0.9	1.1	1.8	0.3	-1.2	-1.4
Forced vital capacity (FVC)	0.9	3.5	9.4	-0.2	-1.1	-3.1
Body fat percentage	0.9	3.4	6.4	1.3	1.5	2.5
Overall health rating	0.9	2.0	3.9	-0.6	-1.3	2.0
Had major operations	0.9	1.0	2.9	-0.1	0.3	1.7
Diabetes diagnosed by doctor	0.9	1.4	3.5	-0.4	-1.9	0.8
Smoking status: Current	0.9	1.5	3.0	-1.2	-1.7	0.3
Unable to work because of sickness or disability	0.9	1.2	3.1	0.3	0.7	1.7
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	1.4	-1.0	-0.9	1.2
Triglycerides	0.8	1.4	2.0	0.6	1.3	1.4
Angina	0.8	1.1	1.4	0.7	1.2	1.2
Medication for hormone replacement therapy	0.8	0.9	1.6	1.0	-0.3	-1.3
Average weekly fortified wine intake	0.8	1.0	2.5	1.6	0.7	-0.0
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.3	-0.7	1.1	0.8
Medication: Levothyroxine sodium	0.8	1.3	2.7	1.0	1.6	0.6
Diabetes (self-reported)	0.8	1.3	3.8	-0.2	-1.9	0.0
Arm fat percentage (right)	0.8	3.0	4.9	1.3	1.5	2.2
Worrier / anxious feelings	0.8	1.5	2.5	-1.6	-1.2	-0.6
Number of live births	0.8	1.2	2.7	-0.9	-1.6	-0.3
Prospective memory result	0.8	1.0	1.7	-1.0	-1.3	0.5
Pulse wave Arterial Stiffness index	0.8	0.9	2.4	-1.6	-0.2	0.4
Blood clot in the leg (DVT)	0.8	1.0	1.5	-1.0	-0.8	1.2
Forced vital capacity (FVC), Best measure	0.8	2.8	8.4	-0.2	0.2	-2.9
Exposure to tobacco smoke outside home	0.8	1.1	2.6	-0.8	-1.6	-0.3
Pulse wave peak to peak time	0.8	0.9	2.3	1.5	0.2	-0.7
Medication: Seretide 50 evohaler	0.8	1.0	2.2	-0.6	-1.5	-0.5
Arm fat percentage (left)	0.8	3.2	5.2	1.4	1.6	2.3
Back pain experienced in last month	0.8	1.2	1.9	1.4	1.2	0.3
Breast cancer (self-reported)	0.8	0.9	1.6	-1.0	-1.3	-0.5
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.7	1.0	1.3	0.2
Illnesses of father: High blood pressure	0.8	1.1	2.2	1.5	0.7	0.7
BMI	0.7	4.0	8.5	1.5	1.1	2.9
Trunk fat percentage	0.7	2.8	5.3	1.2	1.3	2.3
Financial difficulties in last 2 years	0.7	1.0	1.5	-0.8	-0.9	-1.2
Pain all over the body in last month	0.7	0.7	1.9	-0.5	-1.4	-0.1
Medication: Ramipril	0.7	0.9	2.7	-0.1	0.3	1.6
Medication: Amlodipine	0.7	1.0	1.7	-1.3	0.2	1.0
Number of full brothers	0.7	0.9	1.4	1.2	-0.9	-0.7
Wheeze or whistling in the chest in last year	0.7	1.2	3.0	-1.7	-0.8	0.4
Neck or shoulder pain in last month	0.7	1.0	2.5	-0.7	0.2	-1.6
Medication: Allopurinol	0.7	1.0	1.7	0.1	1.3	1.1
Heart disease (mother)	0.7	0.9	1.0	-1.0	-0.8	1.0
Comparative height size at age 10	0.7	3.6	7.7	-2.8	-1.8	0.0
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	2.4	-1.6	0.2	-1.0
Medication for cholesterol	0.7	1.1	2.9	0.1	1.7	-0.5
Osteoarthritis (self-reported)	0.7	0.9	1.4	-1.2	-0.7	-0.8
Leg fat percentage (left)	0.7	2.4	4.7	1.2	1.0	2.2
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.9	-0.7	1.4	0.5
Myopia	0.7	1.0	2.2	0.6	0.6	1.5
Crohns Disease (2017)	0.6	1.3	1.9	-0.8	-1.2	-1.4
Hand grip strength (left)	0.6	1.6	3.2	1.1	1.8	0.6
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.1	-0.4	-1.5	0.3
Vitamin and mineral supplements	0.6	0.8	2.3	1.5	-0.2	-0.4
Medication: Co-codamol	0.6	0.7	1.6	-0.4	1.3	0.7
Medication: Metformin	0.6	0.9	1.4	0.4	-1.0	1.2
Past tobacco smoking	0.6	1.2	2.2	-1.0	-1.5	-0.5
Allergy	0.6	1.3	2.4	0.7	1.6	1.1
Medication: Simvastatin	0.6	0.8	2.0	-0.4	-0.6	1.4
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.3	-0.9	-1.2	0.1
High blood pressure (siblings)	0.6	0.8	1.3	-1.1	-1.0	0.2
Worry too long after embarrassment	0.6	0.9	1.5	-1.1	-0.0	-1.2
Eye problems/disorders: None of the above	0.6	0.7	1.7	0.3	-0.4	-1.3
Qualifications: nursing, teaching	0.6	0.9	2.5	0.4	1.6	-0.2
Financial situation satisfaction	0.6	0.7	1.3	-0.8	-0.6	-1.1
Eye problems/disorders: Glaucoma	0.6	0.7	0.9	0.4	1.0	0.9
Intelligence (Savage-Jansen 2018)	0.5	1.5	2.5	-1.2	1.6	0.7
Major Depression (MDD)	0.5	0.6	0.9	0.9	0.8	0.6
HbA1C	0.5	0.6	0.9	-0.6	-0.9	-0.8
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.2	0.0	-0.7	1.5
Body mass index (BMI)	0.5	2.1	4.5	1.2	0.5	2.1
Illnesses of siblings	0.5	0.7	1.2	0.8	1.1	-0.6
Birth weight	0.5	1.1	3.1	1.8	0.2	-0.5
Leg fat percentage (right)	0.5	1.8	3.2	1.1	0.9	1.8
Emphysema/chronic bronchitis	0.5	0.6	1.7	0.1	0.2	1.3
Whole body fat mass	0.5	2.1	4.7	0.8	1.0	2.2
Alcohol intake frequency.	0.5	1.1	2.3	0.3	-1.0	1.5
Suffer from ‘nerves’	0.5	0.7	1.5	-0.5	0.6	1.2
Family relationship satisfaction	0.5	0.6	1.1	-0.8	-1.0	-0.0
Mood swings	0.5	0.9	2.6	-0.4	-1.6	0.3
Medication: Gliclazide	0.5	0.6	1.3	-0.2	-0.6	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	1.8	1.1	0.6	-1.3
Ever taken oral contraceptive pill	0.5	0.6	0.9	-0.9	0.1	-1.0
Supplements: Calcium	0.5	0.5	1.3	-1.1	0.3	-0.3
Basal cell carcinoma (self-reported)	0.5	0.6	1.3	-0.7	-0.0	1.1
Alcohol drinker status: Previous	0.5	0.6	1.6	1.2	-0.2	0.5
Bipolar Disorder (2018)	0.4	0.6	1.0	1.0	-0.0	-0.9
Alzheimer’s Disease (in father)	0.4	0.5	0.6	0.5	0.8	-0.8
Coronary Artery Disease (CAD)	0.4	0.5	1.0	-0.6	-0.4	1.0
Chronotype (morning person)	0.4	0.8	1.2	-1.1	0.9	0.8
Sensitivity / hurt feelings	0.4	0.6	0.7	-0.9	-0.7	0.9
Townsend deprivation index at recruitment	0.4	0.6	1.9	1.4	-0.0	0.0
Maternal smoking around birth	0.4	0.5	1.3	1.1	-0.5	-0.3
High blood pressure (mother)	0.4	0.6	1.3	0.5	0.5	1.1
Trunk fat mass	0.4	1.8	4.0	0.7	1.0	2.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.4	-1.2	-0.6	0.0
Neuroticism score	0.4	0.9	1.4	-1.2	-1.1	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.7	-0.6	0.3	1.3
Falls in the last year	0.4	0.6	1.4	-1.2	0.4	0.3
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	1.8	1.3	0.6	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.0	0.4	0.5	1.0
Arm fat mass (right)	0.4	1.7	3.9	0.8	0.7	2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	0.8	-0.7	0.6	0.9
Headache pain in last month	0.4	0.6	1.4	-1.2	-0.6	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.9	1.0	0.6	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.7	0.7	-0.8	-0.2
Illnesses of father: None of the above (group 1)	0.4	0.6	1.0	0.2	-0.8	-1.0
Arm fat mass (left)	0.4	1.7	3.6	0.9	0.8	1.9
Average weekly champagne plus white wine intake	0.4	0.6	0.8	-0.8	-0.6	-0.9
Ever smoked	0.4	0.7	0.8	0.9	0.9	0.7
Diastolic blood pressure, automated reading	0.4	1.3	3.2	0.7	-0.5	1.8
Leg fat mass (left)	0.4	1.5	3.2	0.9	0.7	1.8
Depressed Affect (Nagel 2018)	0.3	0.6	1.4	-0.5	-1.2	0.5
Neuroticism (Nagel 2018)	0.3	0.6	1.2	-1.1	-0.8	0.2
Schizophrenia vs Biploar Disorder	0.3	0.4	1.0	-0.4	0.4	1.0
Irritable Bowel Disease (IBD)	0.3	0.8	1.4	0.1	-1.0	-1.2
Age at First Birth	0.3	0.4	0.7	0.6	0.2	0.8
Fasting Glucose	0.3	0.4	0.9	0.3	0.4	0.9
Smoking Status	0.3	0.8	1.0	1.0	0.5	1.0
Neuroticism	0.3	0.8	1.6	-1.2	-1.0	0.1
Tanning	0.3	3.1	8.1	-1.0	-2.9	0.1
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.5	-0.5	-0.6	-0.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.4	-0.6	-0.4	0.7
Diabetes (mother)	0.3	0.4	0.5	-0.7	-0.5	0.7
Hand grip strength (right)	0.3	1.0	2.3	-0.1	1.5	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.7	-0.7	-0.2	0.8
Serious illness, injury or assault to yourself	0.3	0.4	1.0	-0.0	-0.3	-1.0
Multivitamins +/- minerals	0.3	0.4	1.0	0.1	-0.4	-1.0
Alcohol usually taken with meals	0.3	0.5	1.1	-0.5	-1.1	-0.3
Nervous feelings	0.3	0.5	1.1	-1.0	-0.6	0.0
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.5	-0.7	-0.3	-0.7
Qualifications: None of the above	0.3	0.7	2.0	-0.2	0.0	1.4
Noisy workplace	0.3	0.4	0.6	-0.7	0.8	0.3
Length of working week for main job	0.3	0.4	0.5	-0.7	0.5	-0.6
Tense / ‘highly strung’	0.3	0.5	1.3	-0.3	0.1	1.1
Gout (self-reported)	0.3	0.4	1.0	-1.0	-0.1	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.7	0.7	0.4	0.8
Number of children fathered	0.3	0.4	0.6	-0.6	-0.2	-0.8
Qualifications: College or University degree	0.3	1.0	2.0	0.8	1.4	0.7
Ever had bowel cancer screening	0.3	0.3	0.6	-0.8	-0.2	-0.6
Ulcerative Colitis (UC)	0.2	0.4	0.8	0.9	-0.5	-0.4
Crohns Disease (2012)	0.2	0.4	0.6	-0.8	-0.3	-0.6
Blood White Count	0.2	1.4	4.0	-0.3	-2.0	0.2
Height	0.2	2.9	4.4	-2.1	-0.9	-1.9
Allergy or Eczema	0.2	0.6	1.5	-1.2	0.6	-0.3
Taking other prescription medications	0.2	0.3	0.5	-0.6	0.3	0.7
Age when periods started (menarche)	0.2	0.4	0.7	-0.0	-0.9	-0.7
Supplements: Glucosamine	0.2	0.3	0.4	-0.3	-0.6	-0.6
Chronic bronchitis/emphysema (father)	0.2	0.3	0.6	-0.8	0.5	0.2
Waist circumference	0.2	0.8	2.1	0.4	-0.4	1.4
Number of incorrect matches in round	0.2	0.4	0.6	-0.7	-0.8	0.3
Had menopause	0.2	0.3	0.5	-0.0	-0.6	0.7
Fluid intelligence score	0.2	0.4	0.9	0.2	1.0	-0.6
Alcohol intake versus 10 years previously	0.2	0.3	0.8	-0.1	0.4	0.9
Father’s age at death	0.2	0.3	0.6	-0.1	0.8	-0.5
Standing height	0.2	2.0	3.9	-2.0	-0.5	-1.3
Loud music exposure frequency	0.2	0.2	0.4	0.7	-0.4	-0.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.5	-0.0	-0.7	0.4
Medication: Paracetamol	0.2	0.3	0.8	-0.2	0.9	0.3
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.6	-0.3	0.1	-0.8
Age at first live birth	0.2	0.4	0.9	0.3	0.9	-0.4
Leg fat mass (right)	0.2	0.9	2.0	0.7	0.5	1.4
Age at last live birth	0.2	0.3	0.7	0.4	0.8	0.4
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.5	0.5	0.1	0.7
Mother’s age at death	0.2	0.3	0.3	-0.5	0.5	0.6
Medication: Paracetamol	0.2	0.2	0.4	-0.2	0.6	0.5
Ever depressed for a whole week	0.2	0.2	0.6	0.3	0.3	0.7
Pain experienced in last month	0.2	0.3	0.6	0.8	0.3	0.5
Heart disease (siblings)	0.2	0.2	0.7	-0.8	-0.0	0.2
Depression (Nagel 2018)	0.1	0.1	0.2	-0.4	-0.3	0.4
Worry (Nagel 2018)	0.1	0.2	0.5	-0.3	0.0	0.7
Reaction Time	0.1	0.3	0.5	-0.4	0.4	0.7
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	0.6	-0.3	0.2
Blood Eosinophil Count	0.1	0.7	1.1	1.0	-1.0	0.5
Waist Hip Ratio (WHR)	0.1	0.6	1.5	0.0	-0.5	1.2
Impedance of leg (right)	0.1	0.4	0.5	0.5	0.7	-0.6
Fed-up feelings	0.1	0.2	0.4	0.2	-0.3	0.6
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.5	-0.4	-0.7	-0.3
Stomach or abdominal pain in last month	0.1	0.1	0.1	0.3	0.1	-0.4
Sitting height	0.1	0.8	1.8	-0.2	1.3	-0.8
Impedance of leg (left)	0.1	0.3	0.5	0.7	0.7	0.0
Weight	0.1	0.7	2.0	0.1	0.2	1.4
Impedance of arm (right)	0.1	0.2	0.3	-0.5	0.4	-0.5
Trunk fat-free mass	0.1	0.6	0.9	-1.0	-0.9	-0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.2	-0.3	0.3	0.4
Impedance of arm (left)	0.1	0.4	1.1	-0.2	1.1	-0.1
Trunk predicted mass	0.1	0.8	1.1	-1.1	-0.9	-0.5
Mean time to correctly identify matches	0.1	0.2	0.3	-0.1	0.4	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.4	-0.6	0.5	-0.4
Whole body fat-free mass	0.1	0.3	0.5	-0.7	-0.7	-0.0
Leg fat-free mass (right)	0.1	0.3	0.4	-0.6	-0.6	0.5
Average weekly red wine intake	0.1	0.1	0.4	0.6	-0.2	0.1
Whole body water mass	0.1	0.4	0.6	-0.7	-0.8	0.1
Leg predicted mass (right)	0.1	0.3	0.4	-0.5	-0.5	0.6
Arm fat-free mass (left)	0.1	0.7	1.2	-0.8	-1.1	0.4
Irritability	0.1	0.1	0.1	0.3	0.4	0.2
Impedance of whole body	0.1	0.3	0.8	0.2	0.9	-0.4
Arm predicted mass (left)	0.1	0.3	0.7	-0.5	-0.8	0.3
Bipolar Disorder or Schizophrenia	0.0	0.1	0.2	0.5	0.2	-0.3
Schizophrenia (2018)	0.0	0.1	0.2	-0.2	0.2	0.4
Schizophrenia (2014)	0.0	0.1	0.2	-0.3	-0.2	0.4
Ulcerative Colitis	0.0	0.0	0.1	-0.2	-0.3	0.1
Hair Pigment	0.0	0.1	0.2	-0.0	0.5	-0.3
Leg fat-free mass (left)	0.0	0.1	0.2	-0.5	-0.4	0.2
Leg predicted mass (left)	0.0	0.2	0.3	-0.5	-0.4	0.4
Hip circumference	0.0	0.1	0.3	0.2	-0.4	0.5
Arm fat-free mass (right)	0.0	0.2	0.5	-0.3	-0.7	0.2
Medication for pain relief, constipation, heartburn	0.0	0.1	0.1	0.3	-0.2	-0.3
Arm predicted mass (right)	0.0	0.1	0.2	-0.2	-0.4	0.2
Basal metabolic rate	0.0	0.2	0.3	-0.4	-0.5	0.4

Hub : Genes

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Trait associations