Hub : Genes

ARHGAP25

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2720	0.0470	0.0e+00	0.269	0.184	0.289	0.328	0.301	1.1e-32	7.7e-22	1.8e-35	5.5e-41	3.8e-37
2	GTEx	Skin Not Sun Exposed Suprapubic	0.1490	0.0560	4.9e-03	0.109	NA	0.083	NA	0.092	1.4e-06	NA	2.7e-05	NA	1.0e-05
3	ROSMAP	Brain Pre-frontal Cortex	0.3332	0.0511	5.6e-17	0.193	0.197	0.211	0.236	0.228	2.9e-24	1.0e-24	1.5e-26	5.2e-30	7.0e-29
4	TCGA	Ovarian Serous Cystadenocarcinoma	0.0980	0.0440	2.1e-03	0.004	0.041	0.016	NA	0.003	1.7e-01	8.3e-04	2.6e-02	NA	1.9e-01
5	TCGA	Prostate Adenocarcinoma	0.0834	0.0317	2.4e-04	0.063	0.048	0.050	NA	0.053	3.7e-07	8.4e-06	5.4e-06	NA	3.1e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.3	0.5	1.6	-0.1	0.2	-1.0	1.3	-0.2
Bipolar Disorder or Schizophrenia	0.3	0.7	1.7	1.0	-0.1	-0.5	1.3	0.8
Depressed Affect (Nagel 2018)	0.2	0.4	1.3	0.1	0.4	-0.6	1.2	0.3
Depression (Nagel 2018)	0.3	0.4	1.0	1.0	-0.5	0.2	-0.9	0.2
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.9	-0.1	-0.2	-0.1	-1.4	-0.0
Neuroticism (Nagel 2018)	0.3	0.6	1.5	1.2	0.2	0.3	0.8	0.8
Schizophrenia (2018)	0.4	0.8	1.9	1.4	-0.3	0.2	0.7	1.3
Schizophrenia vs Biploar Disorder	0.4	0.5	1.8	-0.3	-0.7	0.3	-1.4	0.1
Worry (Nagel 2018)	0.4	0.9	3.7	1.9	-0.2	0.9	-0.1	0.4
Alzheimer’s Disease (in mother)	0.9	1.0	2.0	0.8	-1.0	1.2	-1.4	0.4
Alzheimer’s Disease (in father)	1.6	1.7	3.5	1.7	0.8	1.9	-1.3	-0.1
Alzheimer’s Disease (including proxy)	2.5	3.6	7.2	2.4	-0.9	2.7	-2.1	0.2
Crohns Disease (2017)	1.2	2.6	7.6	-1.8	-0.9	-2.8	1.1	-0.1
Irritable Bowel Disease (IBD)	0.8	2.0	4.7	-0.5	-0.1	-1.6	2.2	1.5
Ulcerative Colitis (UC)	0.7	1.2	3.2	1.1	0.3	0.6	1.2	1.8
Major Depression (MDD)	0.3	0.3	0.9	-0.5	-1.0	-0.5	-0.4	-0.2
Reaction Time	0.8	1.5	5.5	0.9	-0.1	0.7	-0.8	-2.3
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.3	0.3	0.1	-0.1	-0.6	0.4
Breast Cancer	0.5	1.3	3.2	0.2	1.4	-0.3	1.8	1.1
Ovarian Cancer	1.1	1.4	4.0	1.4	0.9	0.6	-0.2	-2.0
Prostate Cancer	1.2	1.7	3.6	-1.9	0.3	-1.6	1.4	-0.1
Age at First Birth	1.4	2.1	5.3	1.1	1.0	1.0	-2.3	-1.3
Bipolar Disorder (2011)	0.4	0.4	1.1	-0.4	0.3	-1.1	0.7	0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	-0.1	-0.6	-0.2	-0.2	0.1
Coronary Artery Disease (CAD)	3.2	3.8	6.3	2.3	1.6	2.2	-2.5	0.1
Crohns Disease (2012)	0.4	0.6	1.7	-0.4	-0.5	-1.3	-0.2	-0.9
Mean Putamen Volume	0.3	0.3	0.5	-0.7	-0.6	-0.3	0.6	0.7
Fasting Glucose	0.0	0.0	0.0	-0.2	-0.2	-0.2	-0.0	-0.1
HbA1C	1.6	1.8	6.8	1.4	0.1	0.1	-0.2	-2.6
HDL Cholesterol	0.8	1.4	2.6	-1.5	-0.2	-1.5	1.6	-0.2
LDL Cholesterol	0.5	0.8	2.4	1.5	0.4	1.1	-0.3	0.6
Lupus	1.3	2.0	5.3	2.3	-1.4	1.6	-0.2	-0.2
Neuroticism (2016)	0.2	0.3	0.5	0.7	0.6	0.4	-0.6	-0.2
Primary Biliary Cirrhosis	1.7	2.5	5.1	-2.2	-1.5	-2.2	0.5	0.3
Rheumatoid Arthritis	0.1	0.2	0.7	0.1	0.3	-0.4	-0.8	0.2
Schizophrenia (2014)	0.1	0.2	0.8	0.9	-0.1	-0.3	-0.0	0.1
Triglycerides	0.3	0.4	1.4	0.1	0.5	0.3	-1.2	-0.6
Type 2 Diabetes (T2D) (2012)	0.8	0.9	3.8	-0.5	-1.9	-0.1	0.3	0.5
Ulcerative Colitis	0.6	0.9	2.3	0.8	0.7	0.2	1.5	1.0
Blood Eosinophil Count	0.2	1.4	3.5	0.8	0.1	1.2	-1.9	-1.2
Blood Platelet Count	2.7	31.7	76.7	-8.8	-4.1	-7.3	3.4	-0.7
Blood Red Count	0.6	5.4	12.9	-3.6	-2.0	-2.7	1.5	-0.9
Blood White Count	0.8	5.7	10.2	-3.0	-2.2	-1.8	-1.2	-3.2
Heel T-Score	4.3	33.9	69.9	8.4	4.4	7.3	-5.3	0.3
BMI	0.1	0.9	2.0	0.8	-1.4	0.6	0.6	1.0
Height	0.4	7.0	10.0	-2.3	-3.0	-2.0	3.2	2.5
Waist Hip Ratio (WHR)	0.3	1.3	3.5	-1.9	-0.2	-1.4	-0.8	-0.3
Systolic Blood Pressure	2.6	12.8	19.8	3.9	3.7	3.4	-4.5	1.9
Smoking Status	0.2	0.4	0.7	0.3	0.8	0.8	-0.6	-0.6
Allergy or Eczema	0.3	0.8	2.2	0.5	1.1	0.3	-0.6	1.5
Cardiovascular Disease	2.4	7.9	10.7	3.3	2.2	3.1	-2.7	2.7
Hypothyroidism (self reported)	0.7	1.6	4.7	0.9	1.1	0.7	1.0	2.2
Respiratory disease	1.1	2.5	6.0	0.3	-2.5	0.7	-2.1	-1.3
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.6	1.2	0.3	0.1	0.4	0.1
Lung FEV1/FVC ratio	0.3	1.3	3.1	-1.7	-0.0	-1.8	0.8	-0.4
Lung FVC	0.4	2.1	7.7	0.9	2.8	0.8	-0.3	1.1
Neuroticism	0.2	0.4	1.0	0.2	-0.0	-0.8	1.0	-0.4
Chronotype (morning person)	0.5	1.2	3.4	-1.5	-0.0	-1.9	0.4	-0.4
Hair Pigment	0.1	1.8	4.4	-0.6	1.6	-0.7	-2.1	-1.2
Tanning	0.3	3.5	8.9	-1.7	0.4	-1.7	3.0	1.7
Hand grip strength (left)	0.4	1.1	4.6	-2.1	-0.5	-0.3	0.8	0.3
Number of treatments/medications taken	3.6	6.5	12.5	3.5	1.8	2.9	-2.1	2.1
Average weekly spirits intake	0.3	0.3	1.4	0.1	0.2	0.3	1.2	-0.4
Sensitivity / hurt feelings	0.3	0.5	1.7	1.3	0.3	0.1	0.7	-0.3
Frequency of depressed mood in last 2 weeks	1.0	1.5	3.9	2.0	0.5	1.4	-0.9	-0.4
Hearing difficulty/problems: Yes	0.2	0.3	0.9	0.9	0.4	0.6	0.2	0.3
Relative age of first facial hair	0.3	0.6	1.4	-0.8	-0.2	-0.3	-0.9	-1.2
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	5.3	0.5	-2.3	-0.0	1.6	1.6
Ever used hormone-replacement therapy (HRT)	1.3	1.7	5.0	0.2	-1.0	0.1	1.5	2.2
Ever had hysterectomy (womb removed)	0.3	0.4	0.7	0.6	0.5	0.6	0.2	0.8
Systolic blood pressure, automated reading	1.5	4.5	7.8	1.9	2.1	1.8	-2.8	1.8
Eye problems/disorders: Diabetes related eye disease	2.2	2.4	5.3	-1.6	-0.3	-2.3	2.0	-0.6
Angina	1.0	1.3	5.6	0.4	2.4	-0.7	0.1	-0.3
Medication for hormone replacement therapy	0.5	0.5	1.4	0.6	-0.3	0.9	0.1	1.2
Vitamin and mineral supplements	1.4	2.0	5.9	1.1	2.4	1.3	-0.9	0.5
Supplements: Zinc	0.2	0.3	0.5	0.6	0.2	0.6	-0.1	-0.7
Medication: Co-codamol	0.1	0.2	0.4	0.6	-0.3	0.3	-0.4	-0.4
Medication: Metformin	0.9	1.3	3.6	1.9	1.3	1.1	-0.2	-0.0
Diabetes (father)	0.3	0.4	1.0	-0.6	0.1	-0.7	1.0	-0.3
Diabetes (mother)	3.1	4.0	8.1	2.4	-1.2	2.8	-2.1	0.2
Severe depression (siblings)	0.4	0.4	0.9	1.0	0.6	0.8	0.2	-0.2
Pack years adult smoking proportion	1.2	1.8	4.3	2.1	0.5	1.7	-1.0	0.8
Impedance of leg (right)	0.4	2.1	4.0	-2.0	0.0	-1.8	1.6	-0.9
Leg fat-free mass (left)	0.3	1.5	3.7	0.6	-1.9	0.9	0.7	1.5
Trunk fat percentage	0.2	0.7	1.3	1.2	-0.8	0.6	0.7	0.7
Hand grip strength (right)	0.5	1.4	4.1	-2.0	-0.6	-0.4	1.3	0.7
Townsend deprivation index at recruitment	0.5	0.7	2.0	0.1	1.4	0.2	-1.0	-0.7
Current tobacco smoking	1.1	1.9	3.6	1.5	0.6	1.8	-1.9	-0.2
Average weekly fortified wine intake	0.8	0.9	2.7	1.6	-0.1	1.1	0.7	0.6
Maternal smoking around birth	0.5	0.7	1.2	0.8	0.6	1.1	-0.9	-0.5
Fed-up feelings	0.8	1.5	3.7	1.4	1.9	1.0	-0.3	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	3.1	1.8	0.3	1.3	-1.1	-0.2
Relative age voice broke	1.5	2.3	3.1	-1.6	-1.7	-1.8	0.7	-1.5
Taking other prescription medications	3.0	4.6	10.4	3.2	1.1	2.6	-1.2	1.7
Age when periods started (menarche)	0.4	1.0	1.8	1.2	1.1	1.3	-0.3	0.5
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	-0.3	0.1	-0.3	-0.5	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	2.1	4.8	11.6	3.4	2.1	2.6	-0.6	1.0
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.9	0.9	0.4	0.8	-0.5	-1.4
Qualifications: CSEs or equivalent	0.1	0.1	0.2	0.2	-0.2	0.4	0.4	-0.2
Serious illness, injury or assault to yourself	1.2	1.4	3.0	1.7	-0.6	1.2	-1.4	-0.1
High blood pressure	3.0	8.4	11.4	3.4	3.0	2.9	-2.0	3.0
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.8	0.8	1.3	0.3	-0.6	1.2
Multivitamins +/- minerals	0.5	0.6	2.0	-0.6	-1.4	-0.5	0.1	-0.7
Stomach or abdominal pain in last month	0.3	0.4	0.9	0.5	-0.9	0.3	-0.7	-0.3
Supplements: Glucosamine	0.2	0.2	0.5	0.7	-0.5	0.5	0.4	0.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	-0.3	-0.3	0.0	-0.8	-0.6
Medication: Atenolol	1.2	1.5	3.6	1.6	1.9	0.9	-0.5	0.1
Medication: Levothyroxine sodium	1.3	2.2	5.1	0.9	2.2	0.4	-0.3	2.2
Sitting height	0.1	0.6	2.0	0.1	-0.0	0.9	-0.0	1.4
Chronic bronchitis/emphysema (father)	1.0	1.1	1.6	-1.2	1.0	-1.2	0.5	-1.2
High blood pressure (mother)	2.5	3.5	5.5	2.4	1.6	1.9	-1.5	1.8
Body mass index (BMI)	0.4	1.5	4.1	2.0	-0.1	1.8	-0.2	0.3
Impedance of leg (left)	0.3	1.5	3.0	-1.7	0.5	-1.7	1.1	-0.6
Leg predicted mass (left)	0.3	1.5	3.7	0.6	-1.9	0.9	0.7	1.4
Trunk fat mass	0.2	0.9	1.7	0.9	-1.3	0.7	0.8	0.9
Waist circumference	0.1	0.5	0.9	0.6	-1.0	0.3	0.9	0.3
Number of incorrect matches in round	1.0	1.7	3.0	-1.7	-1.1	-1.5	1.4	-0.2
Past tobacco smoking	0.1	0.1	0.3	0.0	-0.5	-0.4	0.2	0.5
Alcohol usually taken with meals	0.9	1.4	2.3	-1.3	-0.5	-1.2	1.5	-1.2
Nervous feelings	0.5	1.0	2.4	1.6	-1.0	1.0	-0.7	-0.1
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	4.8	1.3	0.1	0.9	-2.2	-0.8
Hearing difficulty/problems with background noise	0.9	1.5	2.9	1.7	-0.4	1.2	-0.4	1.7
Hair/balding pattern: Pattern 2	0.1	0.1	0.5	-0.7	-0.3	-0.1	-0.3	-0.1
Had menopause	0.9	1.1	2.4	-0.8	-1.6	-0.8	0.7	1.1
Had other major operations	0.6	0.7	1.8	-0.3	0.3	-1.3	-0.4	-1.2
Forced vital capacity (FVC)	0.4	1.7	3.3	-1.8	-0.9	-1.2	1.4	0.9
Heel bone mineral density (BMD) T-score, automated (right)	2.6	5.9	10.6	3.3	3.2	2.7	-0.8	0.7
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.7	-1.3	-1.0	-1.1	0.1	-0.7
Qualifications: None of the above	1.0	2.1	3.3	1.5	1.7	1.4	-1.8	-0.4
Financial difficulties in last 2 years	1.0	1.3	2.4	1.5	-1.0	1.5	-0.5	1.0
Mouth/teeth dental problems	1.8	2.8	6.2	1.1	0.6	1.6	-1.9	-2.5
Heart attack	0.8	1.0	1.8	1.3	0.5	0.8	0.7	1.4
Allergy	0.2	0.6	2.4	-0.3	0.5	-0.4	1.5	-0.1
Pain all over the body in last month	0.5	0.5	1.2	0.5	-0.4	0.2	1.1	0.9
Diabetes (self-reported)	0.3	0.5	1.0	1.0	1.0	0.1	-0.8	-0.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.8	0.0	0.6	-0.9	-0.3	-0.2
Medication: Ramipril	2.1	2.7	4.5	2.0	1.1	2.1	-2.0	-0.2
Medication: Simvastatin	0.6	0.9	2.6	0.8	0.3	-0.1	1.6	1.2
Fluid intelligence score	0.2	0.5	0.7	0.7	0.9	0.6	-0.5	0.7
Illnesses of siblings	1.1	1.5	3.7	-0.9	-0.6	-1.6	1.9	-0.5
Neuroticism score	0.2	0.4	1.1	1.1	0.0	-0.1	0.4	-0.8
Weight	0.2	0.9	2.1	0.8	-1.5	0.9	0.7	0.8
Impedance of arm (right)	0.6	2.7	5.3	-2.2	-1.6	-2.3	0.5	-0.7
Arm fat percentage (right)	0.2	0.7	1.7	1.3	-1.1	0.8	0.2	0.2
Trunk fat-free mass	0.2	1.0	2.9	-0.1	-1.7	0.4	1.2	0.8
Hip circumference	0.3	1.3	3.8	0.6	-1.9	0.3	1.5	0.5
Time employed in main current job	1.8	2.0	3.2	1.8	-0.7	1.7	-1.3	1.4
Alcohol intake versus 10 years previously	0.8	1.2	3.1	0.8	-0.8	0.8	-1.8	-0.9
Father’s age at death	3.5	4.7	9.0	-3.0	-0.1	-3.0	2.3	-0.9
Worrier / anxious feelings	0.6	1.0	2.8	1.7	1.0	0.8	0.7	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	2.2	0.7	-0.5	0.4	1.5	1.1
Falls in the last year	0.4	0.5	1.6	-0.2	1.3	-0.9	-0.2	0.2
Hair/balding pattern: Pattern 3	1.0	1.5	2.9	1.3	0.5	0.7	-1.5	-1.7
Number of live births	0.6	0.8	1.6	0.3	1.3	0.0	1.2	-1.0
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	6.9	-2.6	-0.6	-2.1	1.5	0.6
Pulse rate	0.5	0.8	1.5	0.6	-0.6	1.1	-1.2	0.7
Happiness	0.4	0.4	0.7	-0.8	-0.8	-0.7	0.2	0.5
Noisy workplace	0.5	0.7	1.0	-0.9	-0.9	-0.8	1.0	-0.2
Qualifications: A levels/AS levels or equivalent	0.3	0.6	2.1	-1.4	-0.0	-0.6	0.6	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.7	0.7	-0.8	0.1	0.8	0.2
Mouth/teeth dental problems: Dentures	0.5	0.9	2.4	0.2	-0.1	-0.0	1.4	1.6
Asthma	0.3	0.6	2.3	0.7	-1.5	0.3	-0.4	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.8	0.9	0.7	0.4	0.9	0.6
Medication: Cholesterol lowering	0.3	0.5	1.5	1.2	0.8	0.6	-0.3	-0.3
Depression (self-reported)	1.8	2.2	3.7	1.7	-1.0	1.9	-1.4	1.2
Medication: Lansoprazole	0.2	0.2	0.7	0.3	-0.2	0.1	-0.2	-0.8
Prospective memory result	0.7	0.9	2.3	0.0	0.5	-0.3	-1.5	-1.3
Lung cancer (father)	1.0	1.2	4.4	0.2	-0.0	-0.0	1.3	-2.1
Illnesses of mother	2.3	2.9	5.3	-1.9	-0.6	-1.9	2.3	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	5.5	-2.4	-0.6	-1.6	1.0	0.5
Pulse wave Arterial Stiffness index	0.7	0.8	2.8	0.5	1.7	0.1	-0.5	0.7
Impedance of arm (left)	0.5	2.4	5.9	-2.1	-1.1	-2.4	0.6	-0.1
Arm fat mass (right)	0.2	0.9	1.6	1.2	-1.2	1.1	0.2	0.6
Trunk predicted mass	0.2	0.9	2.6	-0.2	-1.6	0.4	1.1	0.8
Standing height	0.6	5.9	11.6	-2.7	-3.4	-2.0	2.2	1.4
Length of working week for main job	1.8	2.0	4.7	1.4	-2.2	1.7	0.2	0.7
Exposure to tobacco smoke at home	1.1	1.2	5.5	0.6	0.3	0.3	-0.3	-2.3
Breastfed as a baby	0.7	0.9	1.4	-1.1	-0.7	-0.8	1.2	0.7
Tense / ‘highly strung’	1.1	1.9	2.9	1.1	-1.5	1.6	0.6	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.0	0.7	-0.0	0.0	1.0	0.2
Hair/balding pattern: Pattern 4	0.2	0.5	1.2	-0.2	1.1	-0.7	0.0	-0.8
Birth weight of first child	0.6	1.1	1.8	-1.3	-0.8	-1.0	-0.5	-1.3
Peak expiratory flow (PEF)	0.2	0.4	1.3	-1.1	0.8	-0.2	0.2	0.0
Pulse wave reflection index	1.6	1.9	5.4	-1.0	2.3	-1.4	0.2	-1.2
Ever highly irritable/argumentative for 2 days	0.5	0.7	1.2	0.9	-0.1	1.1	-0.6	-0.9
Loud music exposure frequency	0.7	0.8	3.7	0.0	0.4	-0.3	1.9	-0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.6	0.7	0.0	0.7	0.2	0.8
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.2	-0.2	-0.5	-0.9	0.6	1.1
Blood clot in the leg (DVT)	1.2	1.5	2.3	-1.4	-0.7	-1.4	-1.1	-1.5
Medication: Paracetamol	1.0	1.6	2.7	1.6	0.9	1.6	-1.3	-0.1
Headache pain in last month	0.7	1.3	4.0	2.0	-0.1	1.4	-0.4	-0.5
Medication for cholesterol, blood pressure or diabetes	2.0	3.2	8.7	-3.0	-0.9	-1.9	0.5	-1.7
Glaucoma (self-reported)	0.6	0.7	1.9	-1.4	-0.1	-1.2	0.1	0.3
Gout (self-reported)	0.2	0.2	0.6	-0.3	-0.6	-0.8	0.1	0.0
Hypothyroidism/myxoedema (self-reported)	1.5	2.9	8.3	1.4	1.5	1.3	0.3	2.9
Medication: Amlodipine	3.8	5.4	12.8	3.6	1.7	2.9	-1.2	1.2
Medication: Ventolin 100micrograms inhaler	2.4	3.1	6.4	2.5	-1.0	2.3	-1.2	1.2
Birth weight	0.1	0.3	0.7	-0.6	0.1	-0.9	0.7	0.0
Chronic bronchitis/emphysema (mother)	1.7	2.0	6.6	0.8	-2.6	1.6	-0.2	-0.2
High blood pressure (siblings)	0.9	1.3	3.1	0.9	1.2	1.0	-1.8	-0.2
Forced vital capacity (FVC), Best measure	0.4	1.5	3.5	-1.9	-0.9	-1.0	0.8	1.2
Body fat percentage	0.2	0.8	2.3	1.5	-0.5	1.0	0.6	0.5
Leg fat percentage (right)	0.2	0.9	2.1	1.5	0.3	1.2	0.8	-0.0
Arm fat-free mass (right)	0.2	1.3	3.2	0.6	-0.8	1.0	1.0	1.8
Exposure to tobacco smoke outside home	1.1	1.5	3.7	1.9	1.3	1.2	-0.7	0.3
Comparative body size at age 10	0.2	0.6	2.0	-0.0	-0.5	0.8	1.4	0.2
Number of full brothers	0.3	0.4	1.4	0.6	0.0	1.2	-0.5	-0.3
Worry too long after embarrassment	0.1	0.2	0.5	0.2	-0.7	0.5	0.3	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.0	1.0	0.3	0.5	-0.6	-0.7
Wheeze or whistling in the chest in last year	0.8	1.4	2.9	1.7	-0.3	1.7	-1.1	-0.0
Number of children fathered	1.1	1.3	3.2	-0.9	-1.8	-1.0	0.1	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	-0.6	-0.4	-0.4	-0.6	-0.2
Age at first live birth	0.3	0.6	2.1	-0.5	0.4	-0.3	-1.4	-0.7
Pulse wave peak to peak time	0.8	1.0	3.3	-0.7	-1.8	-0.3	0.8	-0.6
Health satisfaction	0.6	0.7	2.2	0.7	-0.5	0.8	0.1	1.5
Shortness of breath walking on level ground	0.4	0.5	1.6	-0.2	-1.2	-0.7	0.4	-0.4
Qualifications: College or University degree	0.7	2.2	6.5	-2.5	-0.4	-1.8	1.0	-0.5
Eye problems/disorders: None of the above	3.6	4.1	8.7	2.8	1.3	2.9	-1.5	0.5
Mouth/teeth dental problems: Loose teeth	1.0	1.2	3.2	0.6	-0.6	0.7	1.2	1.8
Emphysema/chronic bronchitis	0.9	1.0	2.4	-0.3	-1.6	0.5	-1.1	-1.1
Medication for pain relief, constipation, heartburn	2.0	3.4	6.8	-2.6	-1.9	-2.0	1.3	0.9
Neck or shoulder pain in last month	3.2	4.5	15.5	2.0	-0.4	1.4	-3.9	-1.0
Medication: Blood pressure	2.4	4.3	10.2	3.2	0.9	2.5	-0.6	2.0
Angina (self-reported)	1.1	1.4	6.2	0.7	2.5	-0.5	0.1	-0.2
Migraine (self-reported)	0.8	1.0	2.6	-1.6	-0.4	-1.2	0.6	-0.7
Medication: Ibuprofen	1.3	1.6	2.9	1.7	0.6	1.6	0.9	1.1
Medication: Allopurinol	0.3	0.4	0.7	-0.4	-0.9	-0.8	0.6	0.2
Medication: Omeprazole	1.5	1.8	4.4	0.6	2.1	0.2	-1.2	-1.7
Medication: Seretide 50 evohaler	1.0	1.1	3.8	1.1	-0.1	0.8	-1.9	-0.2
Mean time to correctly identify matches	0.3	0.6	1.4	0.8	-0.4	0.4	-0.7	-1.2
Heart disease (mother)	0.5	0.5	0.8	-0.7	0.7	-0.9	-0.7	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	0.1	-0.3	0.3	-0.5	-0.0
Whole body fat mass	0.3	1.1	1.9	1.4	-1.1	1.1	0.6	0.9
Leg fat mass (right)	0.2	0.8	1.7	1.3	-0.4	1.1	0.6	0.7
Arm predicted mass (right)	0.3	1.4	3.1	0.4	-1.1	0.9	1.4	1.8
Pulse rate, automated reading	0.1	0.3	0.7	-0.8	0.2	-0.1	-0.8	0.3
Alcohol intake frequency.	1.1	2.5	5.4	1.7	-1.6	2.3	-1.4	0.1
Comparative height size at age 10	1.1	6.0	12.0	-2.7	-3.5	-2.1	1.4	2.0
Number of full sisters	0.4	0.5	0.9	0.4	1.0	0.1	-0.9	0.9
Suffer from ‘nerves’	0.7	1.1	3.2	1.8	-0.8	1.1	-0.4	0.7
Overall health rating	1.2	2.7	5.6	2.4	0.4	2.1	-1.8	0.0
Chest pain or discomfort	0.5	0.8	2.3	1.5	0.2	1.0	-0.5	-0.2
Had major operations	0.7	0.8	1.9	1.2	0.5	1.4	-0.3	0.4
Age at last live birth	0.3	0.4	0.8	-0.7	-0.1	-0.9	0.1	-0.9
Family relationship satisfaction	0.9	1.1	1.7	0.7	-1.3	0.7	1.0	1.3
Leg pain on walking	1.3	1.6	4.8	-1.2	-2.2	-0.9	0.9	-0.0
Qualifications: NVQ or HND or HNC or equivalent	2.5	3.0	7.3	2.4	-1.1	2.7	0.3	0.6
Commuting to job workplace: Car/motor vehicle	2.5	2.8	4.8	2.2	0.3	2.1	-2.2	0.3
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.0	-1.0	0.7	-0.7	1.0	-0.5
Medication: Aspirin	0.7	0.9	2.3	1.4	1.5	0.5	0.5	0.3
Supplements: Vitamin C	0.1	0.2	0.4	0.4	-0.7	0.2	0.1	0.5
Knee pain experienced in last month	0.2	0.3	0.7	0.4	0.8	-0.2	-0.3	0.8
Hypertension (Self-reported)	3.5	9.7	14.6	3.8	2.9	3.3	-2.4	2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.3	0.5	0.2	0.8	-0.5	1.2
Illnesses of father: Heart disease	3.2	4.4	8.3	2.2	2.9	2.2	-1.4	1.4
Illnesses of siblings: Diabetes	1.1	1.4	3.3	0.9	-0.9	1.4	0.2	1.8
Smoking status: Previous	0.5	0.7	1.8	-0.5	0.8	-0.4	1.4	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.4	-1.1	-0.5	-1.1	1.5	-0.2
Whole body fat-free mass	0.2	1.2	3.0	0.2	-1.7	0.6	1.1	1.2
Leg fat-free mass (right)	0.2	1.2	2.5	0.6	-1.6	0.9	0.3	1.5
Arm fat percentage (left)	0.2	0.8	1.8	1.3	-1.0	0.8	0.2	0.7
Average weekly red wine intake	0.7	1.1	3.8	-1.9	-0.7	-0.9	0.4	0.4
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.8	0.9	0.1	0.5	0.0	0.3
Mood swings	0.2	0.4	0.9	0.9	0.7	-0.1	-0.1	-0.7
Loneliness, isolation	0.5	0.7	2.0	0.7	-1.4	0.8	-0.3	0.4
Long-standing illness, disability or infirmity	1.3	2.0	5.2	2.3	-0.5	1.5	-0.3	1.5
Ever had bowel cancer screening	3.6	4.2	7.6	2.1	-1.2	2.4	1.3	2.8
Diabetes diagnosed by doctor	0.1	0.1	0.4	0.6	0.3	-0.1	-0.4	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.7	0.8	-0.2	0.7	0.4	1.6
Friendships satisfaction	0.4	0.4	1.3	0.2	-0.8	1.1	-0.5	-0.0
Qualifications: nursing, teaching	1.9	2.9	6.6	-1.7	-2.6	-1.0	1.4	1.5
Commuting to job workplace: Walk	1.6	1.7	3.3	-0.9	1.2	-1.7	1.8	0.2
Eye problems/disorders: Cataract	0.7	0.8	2.0	-1.1	0.1	-1.4	-0.5	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	4.3	-1.4	-0.2	-2.1	0.4	-0.2
Medication for cholesterol	3.4	5.1	8.7	-2.9	-2.3	-2.6	1.4	-1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.3	3.9	9.1	3.0	-0.9	2.9	-0.9	-0.6
Back pain experienced in last month	0.6	0.8	1.5	1.2	0.8	0.7	1.0	0.6
Mineral and other dietary supplements	0.2	0.3	0.8	0.0	0.5	0.2	-0.9	0.4
Breast cancer (self-reported)	0.1	0.1	0.2	0.4	0.1	0.2	-0.1	0.3
Asthma (self-reported)	0.3	0.7	1.9	1.1	-1.4	0.6	-0.3	-0.2
Osteoporosis (self-reported)	1.1	1.4	2.8	-1.7	-1.4	-1.5	0.4	-0.1
Osteoarthritis (self-reported)	1.2	1.5	3.3	1.7	1.8	1.0	-0.5	-0.3
Medication: Aspirin	0.8	1.0	2.7	1.4	1.7	0.3	0.5	0.4
Medication: Gliclazide	3.7	4.2	7.1	-2.7	-1.7	-2.5	2.2	-0.0
Illnesses of father: None of the above (group 1)	2.7	3.4	10.6	-1.8	-3.3	-1.0	1.1	-1.0
Smoking status: Current	1.5	2.3	5.7	1.5	0.5	1.8	-2.4	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.9	-1.0	0.8	-0.8	-0.4	-0.3
Whole body water mass	0.2	1.4	3.0	0.4	-1.7	0.8	1.1	1.4
Leg predicted mass (right)	0.2	1.3	2.9	0.6	-1.7	0.9	0.4	1.5
Arm fat mass (left)	0.2	0.9	1.4	1.1	-1.2	0.9	0.4	1.0
Number of self-reported non-cancer illnesses	4.3	7.5	15.1	3.9	1.2	3.3	-2.5	2.1
Average weekly champagne plus white wine intake	1.2	1.7	2.8	-1.6	-0.6	-1.7	0.5	-1.6
Miserableness	0.4	0.7	1.7	-0.7	0.5	-1.3	1.1	0.2
Guilty feelings	1.0	1.5	3.7	-0.4	-1.1	-1.0	1.9	1.2
Wears glasses or contact lenses	0.4	0.4	1.4	-0.3	-0.2	-0.4	-1.2	-0.6
Ever taken oral contraceptive pill	0.6	0.7	3.0	0.4	-0.4	0.2	-0.5	-1.7
Hearing aid user	2.1	2.3	5.7	-0.2	-1.0	-0.3	2.4	2.2
Mother’s age at death	1.6	2.1	4.9	-1.0	0.9	-1.1	2.2	1.5
Financial situation satisfaction	1.3	1.6	4.0	-0.6	-1.8	-0.0	0.8	2.0
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.2	-0.5	1.1	-0.8	1.1	-0.2
Commuting to job workplace: Public transport	0.3	0.3	1.6	0.1	0.2	0.0	0.3	1.3
Eye problems/disorders: Glaucoma	3.1	3.7	8.1	-2.9	-1.6	-2.4	1.2	0.8
Medication: Blood pressure	2.9	5.6	8.7	2.8	3.0	2.3	-1.7	1.7
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.1	0.8	1.0	0.7	-0.2	0.8
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.5	-1.2	0.1	-1.6	1.6	0.4
High cholesterol (Self-reported)	1.1	2.0	7.8	1.1	2.8	0.2	0.3	0.8
Medication: Bendroflumethiazide	4.3	6.5	13.7	3.2	0.1	3.7	-2.7	1.1
Medication: Paracetamol	2.1	3.3	5.3	2.3	1.5	2.3	-1.9	0.1
Medication: Lisinopril	0.2	0.2	0.5	0.0	0.4	-0.6	0.1	0.7
Medication: Atorvastatin	0.7	0.8	1.9	1.0	0.2	1.1	-0.2	1.4
Illnesses of father: High blood pressure	0.6	0.7	1.6	0.7	1.3	0.5	-0.6	0.8
Alcohol drinker status: Never	3.0	3.6	6.1	2.1	-1.2	2.5	-0.7	2.3
Ever smoked	0.6	1.0	2.9	-0.3	0.6	0.2	-1.3	-1.7
Basal metabolic rate	0.2	1.1	2.8	0.4	-1.7	0.7	1.0	1.1
Leg fat percentage (left)	0.3	1.2	3.1	1.8	0.5	1.5	0.7	0.4
Arm fat-free mass (left)	0.2	1.0	1.6	0.6	-1.0	1.0	1.1	1.3
Number of operations (self-reported)	0.4	0.5	1.7	0.6	0.7	0.3	-1.3	-0.1
Average weekly beer plus cider intake	1.3	1.9	4.6	1.7	-0.5	1.2	-0.6	2.1
Irritability	0.9	1.5	5.0	2.2	0.5	1.3	0.5	0.4
Risk taking	0.2	0.3	0.5	0.1	-0.3	0.7	-0.7	-0.7
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.3	-0.5	-0.5	-0.2	0.6	0.4
Fractured/broken bones in last 5 years	0.4	0.5	1.9	-0.3	-0.4	-0.2	-1.4	-0.4
Age started oral contraceptive pill	0.9	1.1	3.0	0.1	-1.7	0.5	-0.8	-1.2
Diastolic blood pressure, automated reading	1.2	3.7	8.1	1.3	2.8	1.9	-1.7	1.4
Ever depressed for a whole week	0.2	0.2	0.8	-0.9	0.1	-0.6	-0.3	0.0
Unable to work because of sickness or disability	0.6	0.8	2.0	0.8	0.1	0.3	-1.4	-1.0
Commuting to job workplace: Cycle	1.8	2.2	5.2	-2.3	1.1	-2.0	-0.3	-0.8
Myopia	1.1	1.6	3.5	1.4	0.2	1.9	-1.6	-0.2
Vascular/heart problems diagnosed by doctor	3.3	9.0	13.1	-3.6	-3.4	-2.9	1.9	-2.9
Cholesterol lowering medication	1.4	2.1	6.0	1.3	1.1	0.8	1.1	2.5
Medication: Omeprazole (e.g. Zanprol)	2.2	2.7	6.1	0.5	2.5	0.1	-2.0	-1.8
Pain experienced in last month	1.1	1.8	6.2	-2.5	-0.8	-1.4	0.2	0.4
Supplements: Calcium	1.8	1.9	4.0	-1.6	-2.0	-0.9	1.1	-1.0
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	0.3	0.5	-0.6	-0.2	0.2
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.4	1.2	0.5	0.5	0.7	1.5
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.5	-1.0	-0.6	-0.9	-1.2	-1.2
Heart disease (siblings)	0.9	1.1	3.0	1.4	-0.5	1.7	-0.1	0.7
Alcohol drinker status: Previous	1.1	1.2	2.6	0.9	-1.3	1.6	-1.0	0.3
Pack years of smoking	1.3	1.9	4.5	2.1	0.5	1.9	-0.9	0.8
Impedance of whole body	0.4	2.2	4.7	-2.1	-0.6	-2.2	1.1	-0.4
Leg fat mass (left)	0.3	1.2	2.1	1.5	-0.4	1.3	0.7	1.2
Arm predicted mass (left)	0.2	0.9	1.6	0.6	-1.0	1.0	0.9	1.3