Hub : Genes

CCDC93

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0430 0.0170 1.2e-03 0.004 0.026 0.008 0.023 0.010 8.7e-02 3.1e-04 3.0e-02 0.00076 1.8e-02
2 GTEx Artery Tibial 0.1069 0.0468 7.3e-03 0.015 NA 0.035 NA 0.038 2.1e-02 NA 8.7e-04 NA 6.0e-04
3 GTEx Brain Cerebellum 0.2460 0.0890 8.4e-03 0.109 NA 0.021 NA 0.075 4.1e-04 NA 7.8e-02 NA 3.1e-03
4 GTEx Cells Transformed fibroblasts 0.3660 0.0620 6.8e-14 0.099 NA 0.191 NA 0.219 7.5e-08 NA 2.5e-14 NA 2.4e-16
5 GTEx Heart Atrial Appendage 0.2130 0.0570 2.6e-06 0.250 NA 0.202 NA 0.221 1.4e-11 NA 1.9e-09 NA 2.7e-10
6 GTEx Heart Left Ventricle 0.1967 0.0533 6.2e-06 0.144 NA 0.105 NA 0.130 4.1e-08 NA 3.2e-06 NA 2.0e-07
7 GTEx Lung 0.0833 0.0375 8.1e-03 0.040 NA 0.020 NA 0.035 4.9e-04 NA 1.0e-02 NA 9.9e-04
8 ROSMAP Brain Pre-frontal Cortex 0.0538 0.0198 4.5e-04 0.010 0.027 0.010 0.024 0.002 1.4e-02 1.8e-04 1.7e-02 0.00043 1.5e-01
9 YFS Blood 0.0158 0.0070 6.2e-03 0.017 0.007 0.011 0.009 0.014 1.8e-06 1.3e-03 1.5e-04 0.00058 1.8e-05
10 TCGA Breast Invasive Carcinoma 0.0196 0.0119 9.0e-03 0.017 0.013 0.011 NA 0.013 1.7e-04 9.5e-04 2.2e-03 NA 9.4e-04
11 TCGA Head and Neck Squamous Cell Carcinoma 0.0381 0.0198 7.5e-03 0.010 0.012 0.018 NA 0.014 2.5e-02 1.4e-02 3.5e-03 NA 8.5e-03
12 TCGA Brain Lower Grade Glioma 0.0665 0.0270 3.9e-05 0.036 0.036 0.035 NA 0.028 5.8e-05 4.9e-05 6.2e-05 NA 3.5e-04
13 TCGA Lung Squamous Cell Carcinoma 0.0819 0.0337 1.8e-07 0.050 0.079 0.084 NA 0.049 2.0e-06 2.7e-09 9.3e-10 NA 2.8e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bipolar Disorder (2018) 0.6 1.0 4.3 -2.1 1.1 -0.7 1.0 -1.2 -1.2 0.9 -0.5 -0.2 -0.4 0.5 -0.2 1.1
Bipolar Disorder or Schizophrenia 0.8 1.9 8.6 -1.5 2.9 -1.3 1.7 0.1 0.1 0.1 -0.4 -1.5 0.8 2.0 0.3 1.4
Depressed Affect (Nagel 2018) 1.0 2.0 4.4 -1.7 -0.7 0.0 -1.4 -1.8 -1.6 0.2 -1.7 1.6 -2.1 -1.8 -1.3 -0.3
Depression (Nagel 2018) 1.0 1.5 7.0 -0.2 -0.7 0.9 -0.1 -2.6 -2.4 2.0 -0.2 0.8 -0.1 -0.6 0.3 0.3
Intelligence (Savage-Jansen 2018) 4.2 13.1 36.0 -1.4 3.3 -1.0 6.0 -1.4 -1.4 3.6 0.3 -4.3 5.2 5.1 3.8 4.1
Neuroticism (Nagel 2018) 1.0 2.5 6.2 -2.2 -1.0 -0.6 -0.7 -2.5 -2.3 1.2 -1.3 1.3 -2.0 -1.9 -1.1 -0.3
Schizophrenia (2018) 0.9 2.0 8.4 -0.2 2.9 -1.2 1.3 1.1 1.1 -0.6 -0.1 -1.8 1.3 2.2 0.6 1.0
Schizophrenia vs Biploar Disorder 1.1 1.4 4.0 2.0 0.8 0.7 -1.5 1.8 1.6 -1.8 1.0 0.4 -0.3 -0.1 -0.0 -0.9
Worry (Nagel 2018) 0.7 1.5 3.0 -1.7 -1.2 -0.7 -0.6 -1.4 -1.2 0.8 -1.0 1.0 -1.7 -1.7 -1.4 -0.7
Alzheimer’s Disease (in mother) 1.0 1.2 4.3 0.2 0.4 0.4 1.0 -1.9 -1.7 2.1 -0.1 -0.1 0.8 0.7 1.3 0.7
Alzheimer’s Disease (in father) 1.6 1.7 5.9 -0.4 0.5 0.4 0.6 -2.4 -2.4 1.8 1.5 0.7 -0.4 -0.3 1.4 0.9
Alzheimer’s Disease (including proxy) 1.3 1.9 6.3 0.8 0.5 0.6 0.6 -2.5 -2.4 2.3 1.5 0.5 0.2 0.2 1.8 0.3
Crohns Disease (2017) 0.5 1.1 3.1 -1.0 -0.7 0.8 -1.0 -0.9 -1.0 0.2 1.1 1.8 -1.5 -1.7 -0.1 -0.0
Irritable Bowel Disease (IBD) 0.5 1.2 3.6 -1.9 0.2 -0.1 0.1 -1.7 -1.7 1.1 1.0 1.0 -1.1 -0.9 0.3 0.7
Ulcerative Colitis (UC) 0.6 1.1 2.7 -1.4 0.9 -1.0 1.3 -1.5 -1.5 1.6 0.3 -0.6 0.1 0.5 0.8 0.8
Major Depression (MDD) 2.7 3.3 13.1 -3.6 1.0 0.3 -0.3 -2.1 -2.2 0.2 1.1 2.2 -2.2 -1.5 -0.1 2.3
Reaction Time 0.9 1.6 4.2 -0.0 0.9 0.3 1.9 -0.5 -0.5 1.9 1.1 -1.2 2.0 1.7 1.8 0.2
Verbal and Numeric Reasoning (VNR) 4.4 10.5 30.7 -1.2 2.4 -0.6 5.5 -1.7 -1.7 3.9 -0.1 -3.5 4.6 4.3 3.5 3.5
Breast Cancer 0.8 1.8 7.0 -1.3 -1.7 0.3 1.7 -1.6 -1.6 2.6 0.8 0.1 0.7 -0.4 1.6 0.5
Ovarian Cancer 0.1 0.2 0.9 0.2 0.1 0.6 0.2 0.1 0.0 0.3 1.0 0.2 0.6 0.4 0.6 0.1
Prostate Cancer 0.5 0.8 3.4 -1.8 0.0 -0.4 0.7 -1.1 -1.1 1.2 -1.1 0.2 -0.2 -0.3 0.3 0.4
Age at First Birth 1.6 2.3 7.6 1.5 2.8 -0.7 -0.1 1.6 1.4 -2.1 2.1 -1.3 0.7 1.7 0.5 0.8
Bipolar Disorder (2011) 1.6 1.5 6.7 -1.4 2.5 0.7 1.1 -0.5 -0.7 0.3 0.4 0.5 0.3 1.1 1.0 2.6
Body Mass Index (BMI) (2010) 1.4 1.9 4.3 -0.8 -1.7 -0.8 -1.1 -1.5 -1.3 0.5 -0.8 1.1 -2.1 -2.0 -1.9 -1.1
Coronary Artery Disease (CAD) 2.0 2.4 5.5 -1.0 1.5 -0.4 2.1 -1.5 -1.6 1.6 1.4 -1.1 1.5 1.6 2.3 1.5
Crohns Disease (2012) 0.5 0.8 2.7 -1.6 -0.2 -0.3 -0.9 -0.4 -0.4 -0.4 0.2 0.9 -1.6 -1.2 -1.0 0.1
Mean Putamen Volume 0.4 0.5 1.3 0.6 -0.2 0.4 -1.1 -0.1 -0.1 -0.7 0.5 1.2 -1.2 -0.7 -0.7 -0.1
Fasting Glucose 0.5 0.6 1.9 -1.4 0.8 -1.0 0.6 -0.2 -0.2 0.2 0.3 -1.3 0.3 1.1 0.7 0.1
HbA1C 1.7 1.9 7.2 0.6 0.1 -0.3 1.8 1.0 1.0 0.6 -0.6 -2.3 2.7 2.0 1.2 0.1
HDL Cholesterol 0.5 0.8 2.0 0.6 1.2 0.8 0.1 0.8 0.8 -1.1 -0.8 -0.5 1.0 1.4 -0.2 1.0
LDL Cholesterol 1.7 2.6 12.1 1.6 0.5 -3.5 0.8 0.6 0.8 -0.3 0.0 -3.1 0.9 1.4 1.1 -2.0
Lupus 0.7 1.0 3.2 1.3 0.2 0.4 -1.8 0.5 0.5 -1.4 -0.1 1.1 -1.4 -0.8 -0.8 -0.9
Neuroticism (2016) 0.1 0.2 0.6 -0.7 -0.2 -0.0 -0.1 -0.5 -0.6 -0.1 0.2 0.8 -0.5 -0.5 -0.3 0.3
Primary Biliary Cirrhosis 1.0 1.4 4.5 -1.9 1.0 -0.5 1.4 -0.7 -0.7 0.7 -2.1 -0.7 0.6 0.8 0.0 2.1
Rheumatoid Arthritis 0.2 0.3 1.3 -0.6 -0.5 -0.0 0.6 -0.9 -0.9 1.2 -0.5 0.0 0.1 -0.1 0.1 0.3
Schizophrenia (2014) 0.2 0.5 3.0 0.0 1.7 -0.3 -0.0 0.8 0.7 -0.8 0.6 -0.3 0.0 0.7 -0.1 0.3
Triglycerides 0.5 0.9 3.2 -0.6 -1.8 -1.0 -0.4 0.1 0.2 0.5 -0.3 0.1 -0.9 -1.4 -1.1 -1.6
Type 2 Diabetes (T2D) (2012) 1.3 1.5 4.1 -0.1 -0.3 -1.4 0.8 2.0 2.0 -1.0 -1.5 -1.8 1.0 0.9 -0.8 -0.3
Ulcerative Colitis 0.9 1.4 6.2 -2.5 0.4 -1.0 1.0 -1.6 -1.6 0.9 -0.1 0.1 -0.6 -0.1 -0.3 1.8
Blood Eosinophil Count 0.1 0.6 1.8 -1.0 -1.0 -0.2 0.6 -1.2 -1.1 1.3 -0.5 0.2 -0.1 -0.6 -0.2 -0.0
Blood Platelet Count 0.1 0.8 3.9 -0.6 0.3 -2.0 0.7 0.7 0.7 -0.5 -0.8 -1.5 0.1 0.3 -1.0 -0.1
Blood Red Count 0.2 1.6 5.5 -1.9 1.3 -0.7 1.5 0.2 0.2 0.7 -2.3 -1.2 1.0 1.2 -0.0 1.6
Blood White Count 0.2 1.8 4.8 -1.5 -1.6 0.3 0.4 -2.2 -2.1 2.1 0.3 1.1 -1.0 -1.6 0.1 -0.1
Heel T-Score 1.0 8.3 58.2 7.6 -0.1 1.2 -3.9 0.8 0.6 -2.4 2.1 1.9 -2.0 -1.3 1.8 -3.1
BMI 0.7 4.2 9.5 -2.5 -2.7 -0.1 -0.9 -1.7 -1.5 0.7 -2.0 2.1 -2.8 -3.1 -3.0 -0.1
Height 0.1 1.1 3.0 -0.2 -0.4 1.7 1.2 0.5 0.4 0.5 -1.6 -0.1 1.6 0.9 0.1 1.6
Waist Hip Ratio (WHR) 0.5 2.3 7.6 1.0 2.8 -0.7 0.8 1.6 1.5 -1.4 2.1 -1.5 1.0 1.9 0.8 0.9
Systolic Blood Pressure 0.3 1.7 3.7 1.9 0.6 1.4 -1.9 1.2 1.0 -1.8 1.9 1.5 -1.0 -0.7 -0.2 -0.5
Smoking Status 1.5 3.5 12.8 -1.4 -1.7 -0.8 1.1 -3.6 -3.4 3.4 -0.4 0.7 -0.9 -1.4 0.3 0.3
Allergy or Eczema 0.4 1.0 3.6 -1.9 -0.4 -1.8 -0.2 -0.9 -0.8 0.0 -0.6 0.2 -1.3 -0.9 -1.2 -0.4
Cardiovascular Disease 0.4 1.5 5.4 0.4 -0.3 -2.0 -1.4 -0.4 -0.2 -0.3 1.0 -0.1 -2.0 -1.4 -0.8 -2.3
Hypothyroidism (self reported) 1.2 2.7 4.9 -1.0 1.8 1.2 2.2 -1.2 -1.2 1.9 -0.9 -0.5 2.0 1.9 2.2 2.1
Respiratory disease 1.2 2.7 8.4 -2.0 -1.0 -1.6 0.3 -2.5 -2.1 2.1 -2.9 -0.4 -0.8 -0.8 -1.3 -0.9
Type 2 Diabetes (T2D) (2018) 0.3 0.6 1.9 -1.4 0.7 -0.9 -0.0 -0.6 -0.6 -0.3 0.2 0.3 -1.2 -0.6 -0.9 0.8
Lung FEV1/FVC ratio 0.2 0.9 5.4 -2.3 0.4 -0.6 0.5 -0.5 -0.8 0.1 1.0 0.5 -1.0 -0.5 0.3 1.6
Lung FVC 0.1 0.7 3.8 0.8 -1.6 0.2 -0.4 -0.0 0.1 0.8 -0.2 -0.1 0.3 -0.7 -0.2 -2.0
Neuroticism 1.2 2.9 7.2 -2.7 -1.3 -1.4 -0.3 -2.5 -2.3 1.4 -1.7 0.8 -2.0 -1.9 -1.1 -0.5
Chronotype (morning person) 0.5 1.1 4.9 -0.1 -1.5 1.7 -0.1 -0.1 -0.3 0.1 2.2 1.3 -0.3 -1.2 0.2 0.6
Hair Pigment 0.1 2.3 5.8 -1.7 0.9 -2.4 1.3 -1.8 -1.8 1.7 2.4 -1.2 -0.6 -0.0 1.5 0.2
Tanning 0.2 2.5 6.6 2.6 -0.7 2.3 -1.6 2.1 1.9 -1.9 1.8 1.7 0.1 -0.7 -0.2 -0.8
Hand grip strength (left) 1.4 3.6 10.9 -1.5 -2.9 0.8 -1.7 -0.9 -0.9 0.2 -0.5 2.7 -2.7 -3.3 -2.0 -0.9
Number of treatments/medications taken 0.3 0.5 1.4 -1.2 -0.3 -0.1 0.4 -1.1 -0.9 1.2 -0.4 0.2 -0.3 -0.6 -0.6 0.1
Average weekly spirits intake 0.8 1.0 2.5 0.1 -0.8 -1.5 -0.8 0.3 0.5 -0.6 -1.5 -0.4 -1.0 -0.7 -1.6 -1.5
Sensitivity / hurt feelings 0.5 0.8 2.7 -0.5 -0.6 -0.4 -0.8 -1.0 -0.9 0.6 -1.6 0.6 -1.4 -1.1 -0.6 -0.9
Frequency of depressed mood in last 2 weeks 1.4 2.0 6.7 -1.7 -0.4 0.9 0.4 -2.6 -2.4 2.3 -1.4 0.9 -0.1 -0.6 0.4 0.8
Hearing difficulty/problems: Yes 0.3 0.5 1.7 -0.3 1.3 -0.5 0.6 -0.7 -0.8 0.1 0.7 -0.2 -0.2 0.5 0.6 1.3
Relative age of first facial hair 0.4 0.8 2.4 -0.3 0.1 1.2 1.0 0.2 0.0 0.5 1.2 0.1 1.3 0.9 1.6 1.2
Other serious medical condition/disability diagnosed by doctor 1.0 1.4 5.5 -1.1 -2.3 -1.4 -0.2 -0.2 -0.0 0.2 -1.3 -0.1 -0.9 -1.4 -1.6 -1.4
Ever used hormone-replacement therapy (HRT) 0.7 0.9 2.3 0.5 -1.5 0.1 -0.9 -0.5 -0.2 0.3 -1.5 0.6 -0.7 -1.2 -1.2 -1.4
Ever had hysterectomy (womb removed) 0.7 0.8 4.0 -2.0 0.7 0.5 0.5 -0.7 -0.9 0.3 0.2 0.9 -0.5 -0.4 0.5 1.6
Systolic blood pressure, automated reading 0.6 1.6 4.9 2.2 1.2 0.6 -1.3 1.9 1.8 -2.0 1.1 0.2 -0.3 0.4 -0.2 -0.4
Eye problems/disorders: Diabetes related eye disease 2.1 2.3 5.2 1.2 -2.0 0.7 -2.3 0.9 0.9 -1.2 -0.9 1.7 -1.5 -1.9 -1.7 -1.7
Angina 0.7 0.9 2.8 -1.5 0.4 -0.7 -0.5 -1.3 -1.2 -0.2 0.2 0.9 -1.7 -1.0 -1.0 0.6
Medication for hormone replacement therapy 0.9 1.0 3.5 -1.9 -0.4 -1.4 0.3 -1.4 -1.2 0.8 -0.9 -0.1 -1.0 -0.6 -0.7 -0.3
Vitamin and mineral supplements 2.7 3.7 8.0 0.9 -2.0 -0.9 -2.8 1.0 1.0 -2.0 -0.4 1.4 -2.7 -2.6 -2.5 -2.3
Supplements: Zinc 0.8 0.9 2.3 -0.4 1.5 1.0 1.2 -0.4 -0.4 0.7 0.7 -0.1 1.0 1.1 1.1 1.4
Medication: Co-codamol 1.7 2.0 9.9 0.1 -1.6 -0.9 -0.7 0.9 1.1 -0.2 -3.1 -0.5 -0.2 -0.6 -2.1 -2.2
Medication: Metformin 0.8 1.2 3.6 0.4 0.4 -1.5 -0.4 1.6 1.6 -1.9 -0.8 -1.0 -0.2 0.1 -1.1 -0.6
Diabetes (father) 3.7 4.6 10.8 0.4 -1.2 -1.6 -1.6 3.2 3.3 -3.0 -2.2 -0.7 -0.9 -0.7 -3.3 -2.4
Diabetes (mother) 1.6 2.0 4.9 2.0 0.1 -0.5 -1.8 2.0 2.1 -2.0 -0.0 -0.3 -0.5 -0.2 -0.9 -2.2
Severe depression (siblings) 1.9 2.2 4.4 2.1 -1.1 0.0 -2.1 1.5 1.6 -1.8 1.7 0.8 -1.1 -0.9 -1.1 -1.9
Pack years adult smoking proportion 0.3 0.4 1.2 -0.7 0.9 0.0 -0.4 -0.8 -0.9 0.4 0.0 0.9 -1.1 -0.6 0.2 -0.2
Impedance of leg (right) 0.3 1.3 8.1 2.8 0.4 0.8 -0.3 -0.7 -0.7 1.3 0.7 0.4 0.4 0.1 1.6 -1.4
Leg fat-free mass (left) 0.3 1.4 5.5 -1.9 -1.6 0.1 -0.0 0.6 0.6 -0.7 -2.4 0.4 -0.4 -0.8 -2.1 0.7
Trunk fat percentage 0.6 2.3 5.6 0.5 -1.6 1.1 -1.9 -0.2 -0.1 -0.4 -1.2 2.3 -2.0 -2.4 -1.9 -1.0
Hand grip strength (right) 0.4 1.0 2.4 -1.4 -1.3 0.4 -0.6 0.3 0.2 -0.2 -0.8 1.2 -1.2 -1.6 -1.5 -0.1
Townsend deprivation index at recruitment 0.4 0.6 2.8 -0.2 -0.9 1.5 0.1 0.3 0.3 -0.2 -1.7 0.7 0.4 -0.3 0.1 0.6
Current tobacco smoking 0.6 1.0 4.5 0.2 -0.7 0.3 0.2 -1.7 -1.7 2.1 -0.1 0.8 -0.3 -0.8 0.8 -0.6
Average weekly fortified wine intake 0.4 0.5 1.6 -0.2 0.9 -0.7 0.7 0.0 0.1 -0.1 -1.3 -1.1 0.8 1.1 0.2 0.3
Maternal smoking around birth 0.5 0.7 5.3 1.3 0.8 -0.5 0.2 -0.2 -0.2 -0.2 2.3 -0.6 0.2 0.4 1.0 0.0
Fed-up feelings 0.7 1.3 9.1 -0.3 -0.9 -0.3 -0.8 -0.6 -0.5 0.4 -3.0 0.5 -0.9 -1.1 -1.4 -0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 2.7 3.6 13.7 -0.9 -0.8 1.3 0.1 -3.7 -3.5 3.3 1.0 1.6 -0.6 -1.1 1.1 0.5
Relative age voice broke 0.2 0.4 1.1 0.2 -0.9 0.3 0.4 1.0 1.0 -0.1 -0.9 -0.4 0.7 0.3 -0.1 -0.3
Taking other prescription medications 0.5 0.8 2.0 -0.8 -1.1 -0.3 -0.7 -0.1 -0.0 -0.2 -1.2 0.7 -1.2 -1.3 -1.4 -0.9
Age when periods started (menarche) 0.2 0.4 1.0 -0.8 -0.3 0.5 0.4 -0.5 -0.6 1.0 -0.8 0.8 -0.2 -0.7 0.1 0.7
Bilateral oophorectomy (both ovaries removed) 1.1 1.3 6.4 -2.1 0.4 0.6 1.5 -0.3 -0.5 0.3 -1.3 0.0 0.6 0.8 0.4 2.5
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.7 8.8 3.0 -1.0 0.4 -2.5 0.4 0.4 -1.4 0.6 1.7 -2.3 -2.0 -0.8 -1.8
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 2.7 1.2 -0.1 1.2 -1.6 -0.1 -0.2 -0.2 0.7 1.6 -1.3 -1.1 -0.6 -0.6
Qualifications: CSEs or equivalent 0.8 1.0 2.6 0.9 -1.3 -0.2 -1.6 0.0 -0.0 -0.9 -0.5 0.9 -1.3 -1.4 -0.3 -1.5
Serious illness, injury or assault to yourself 0.5 0.6 2.0 -1.4 -0.7 -0.7 -0.1 -0.9 -0.8 0.7 -0.2 0.1 -0.8 -0.8 -0.7 -0.5
High blood pressure 1.1 3.0 7.9 1.8 -0.3 0.4 -2.8 0.6 0.6 -1.3 2.3 1.8 -2.4 -2.0 -1.3 -2.2
Hayfever, allergic rhinitis or eczema 0.4 0.8 2.1 -1.2 -1.1 -0.5 -0.8 -0.8 -0.8 -0.3 0.3 0.9 -1.4 -1.4 -0.6 -0.5
Multivitamins +/- minerals 1.4 1.8 4.6 -0.4 1.4 0.2 2.0 -0.5 -0.5 0.9 0.8 -1.4 2.0 2.1 1.7 1.3
Stomach or abdominal pain in last month 0.3 0.4 1.0 -0.8 0.2 0.2 -0.6 -1.0 -0.9 0.3 -0.4 0.8 -0.9 -0.4 -0.6 0.2
Supplements: Glucosamine 1.3 1.7 5.6 -0.8 -0.0 0.5 2.1 -0.5 -0.3 1.2 -0.5 -1.4 2.4 1.9 0.9 1.6
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.8 -0.7 -1.2 0.3 -0.7 -0.5 -0.5 0.0 0.2 1.2 -1.2 -1.4 -0.4 -0.1
Medication: Atenolol 0.6 0.7 2.3 0.6 -0.3 0.6 -1.5 0.1 0.1 -0.3 -0.6 1.2 -1.1 -1.0 -1.1 -1.0
Medication: Levothyroxine sodium 1.3 2.2 6.2 -0.5 2.0 2.3 1.3 -0.6 -0.8 1.0 0.9 0.5 1.3 1.4 2.5 2.2
Sitting height 0.2 1.1 3.9 1.4 0.1 0.8 1.2 0.0 0.1 1.2 -0.9 -0.8 2.0 1.5 1.1 0.5
Chronic bronchitis/emphysema (father) 1.7 2.0 5.9 0.2 -0.3 0.7 -2.4 0.1 0.0 -1.7 0.3 2.3 -2.3 -1.9 -1.4 -0.6
High blood pressure (mother) 0.5 0.7 2.3 0.1 1.2 0.4 0.2 1.5 1.4 -1.1 0.0 -0.6 0.8 1.1 0.1 0.2
Body mass index (BMI) 0.8 3.4 9.1 -1.6 -2.5 0.4 -1.6 -0.8 -0.7 -0.2 -1.6 2.3 -2.7 -3.0 -2.8 -0.6
Impedance of leg (left) 0.3 1.5 6.8 2.6 -0.1 1.2 -0.6 -1.0 -1.0 1.4 1.1 1.1 -0.1 -0.5 1.7 -1.4
Leg predicted mass (left) 0.3 1.4 5.4 -1.8 -1.6 0.1 -0.0 0.7 0.7 -0.8 -2.3 0.3 -0.3 -0.7 -2.1 0.7
Trunk fat mass 0.6 2.6 6.5 -0.4 -1.9 1.0 -1.7 -0.3 -0.2 -0.4 -1.7 2.4 -2.2 -2.5 -2.3 -0.5
Waist circumference 0.4 1.6 4.9 -1.3 -1.9 0.4 -0.9 0.2 0.2 -0.4 -1.2 1.4 -1.5 -2.0 -2.2 -0.3
Number of incorrect matches in round 0.3 0.6 1.6 -1.1 1.3 -0.1 -0.3 -0.3 -0.4 -0.4 0.6 0.7 -1.1 -0.2 -0.4 1.3
Past tobacco smoking 0.6 1.0 4.8 -0.5 2.2 0.9 0.4 0.5 0.3 -0.5 1.1 -0.1 0.9 1.3 1.4 1.1
Alcohol usually taken with meals 0.4 0.6 2.1 0.4 -0.2 -0.7 1.0 0.5 0.6 0.3 -1.0 -1.5 1.2 1.1 0.1 0.0
Nervous feelings 0.2 0.3 1.2 -1.1 -0.2 -0.2 -0.4 -0.3 -0.3 0.3 -0.3 0.7 -0.9 -0.8 -0.7 -0.1
Frequency of tenseness / restlessness in last 2 weeks 1.9 2.9 5.9 -1.4 -2.0 1.6 -0.6 -2.4 -2.3 2.2 -0.6 2.4 -1.4 -2.2 -0.5 -0.0
Hearing difficulty/problems with background noise 0.2 0.3 0.8 0.6 0.1 -0.2 -0.8 0.4 0.3 -0.7 0.2 0.6 -0.9 -0.6 -0.1 -0.3
Hair/balding pattern: Pattern 2 0.3 0.4 1.3 -0.5 0.1 -0.1 0.1 -0.8 -0.8 0.6 1.1 -0.0 -0.2 -0.3 1.1 -0.5
Had menopause 0.4 0.5 1.6 0.9 0.0 1.0 -1.3 0.3 0.3 -0.7 0.0 0.9 -0.7 -0.8 -0.2 -0.7
Had other major operations 0.7 0.8 5.5 0.6 -0.4 0.9 -0.4 -0.7 -0.7 0.8 2.3 0.7 -0.4 -0.7 0.6 -0.8
Forced vital capacity (FVC) 0.1 0.3 0.9 0.3 -0.9 0.7 0.2 -0.0 -0.0 0.9 -0.6 0.0 0.7 -0.1 0.3 -0.8
Heel bone mineral density (BMD) T-score, automated (right) 1.7 3.8 10.6 3.2 -1.0 1.4 -3.0 0.7 0.6 -2.0 1.3 2.6 -2.5 -2.2 -0.7 -1.4
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 2.3 -1.0 1.5 1.0 0.7 -1.2 -1.3 1.3 1.0 0.7 0.3 0.6 1.2 1.3
Qualifications: None of the above 2.3 4.9 12.6 2.0 -1.6 2.7 -3.5 1.5 1.3 -1.9 0.6 3.2 -2.3 -2.7 -1.3 -2.4
Financial difficulties in last 2 years 0.2 0.3 1.3 0.6 -0.5 0.0 0.6 -0.0 0.1 0.2 -0.8 -0.9 1.1 0.6 0.1 0.0
Mouth/teeth dental problems 0.9 1.4 3.8 -1.0 1.1 -1.6 1.7 0.4 0.3 -0.4 -0.1 -1.7 1.1 1.6 0.2 2.0
Heart attack 1.2 1.5 4.8 0.5 -2.2 0.3 -1.6 0.5 0.5 -0.8 0.0 1.1 -1.2 -2.1 -1.0 -1.8
Allergy 1.3 3.0 6.9 2.0 2.2 1.2 1.3 1.7 1.5 -0.5 1.2 -1.4 2.5 2.6 1.6 1.5
Pain all over the body in last month 1.2 1.2 5.6 2.4 -0.5 1.2 -1.2 -0.8 -0.6 0.6 0.2 1.3 -0.6 -0.8 -0.0 -1.8
Diabetes (self-reported) 0.7 1.0 2.6 -0.4 -0.1 -1.4 0.2 1.3 1.4 -1.5 -1.2 -1.1 0.1 0.2 -1.6 0.1
Hayfever/allergic rhinitis (self-reported) 1.2 1.6 5.1 -1.1 -0.7 1.9 -0.3 -1.6 -1.7 1.4 0.3 2.3 -0.8 -1.3 0.5 0.5
Medication: Ramipril 0.6 0.8 2.9 0.1 1.2 1.1 -0.7 -0.5 -0.7 -0.3 1.7 1.3 -0.8 -0.2 0.9 0.7
Medication: Simvastatin 2.3 3.3 11.7 0.7 2.3 -3.4 -0.2 1.5 1.7 -2.6 -0.9 -2.8 0.3 1.7 -1.0 -0.9
Fluid intelligence score 4.3 8.8 29.2 -1.7 1.6 -1.0 5.4 -0.8 -0.8 3.5 -0.7 -3.8 4.6 3.9 2.7 2.8
Illnesses of siblings 0.3 0.5 1.8 -0.1 0.5 -1.1 0.6 0.1 0.1 -0.2 -1.1 -1.3 0.7 1.0 0.2 0.1
Neuroticism score 0.9 1.9 4.5 -2.1 -1.1 -0.7 -0.2 -2.0 -1.9 1.5 -1.8 0.8 -1.4 -1.5 -0.7 -0.3
Weight 0.6 3.1 7.3 -1.5 -2.7 1.0 -1.3 -0.4 -0.3 -0.1 -2.1 2.2 -2.0 -2.7 -2.6 -0.2
Impedance of arm (right) 0.7 3.1 12.2 3.5 1.4 0.3 0.6 1.6 1.6 -0.1 1.4 -1.6 2.4 2.2 2.1 -1.1
Arm fat percentage (right) 0.5 1.9 5.1 0.2 -1.6 0.3 -1.7 -0.1 -0.0 -0.5 -0.6 1.8 -2.1 -2.3 -2.0 -1.1
Trunk fat-free mass 0.2 1.2 4.8 -1.9 -1.6 0.0 -0.0 0.2 0.2 -0.2 -2.2 0.4 -0.6 -0.9 -1.9 0.6
Hip circumference 0.7 2.9 7.7 -1.5 -2.8 1.7 -0.7 -0.9 -0.9 0.8 -2.1 2.4 -1.4 -2.4 -2.0 0.2
Time employed in main current job 1.7 2.0 5.3 0.8 -0.1 -1.1 -1.9 1.5 1.5 -2.0 -0.8 0.5 -1.8 -1.1 -2.3 -1.2
Alcohol intake versus 10 years previously 0.3 0.4 1.8 0.1 0.3 0.4 -0.2 1.4 1.2 -1.0 0.4 0.0 0.4 0.1 0.2 0.0
Father’s age at death 1.4 1.9 5.0 -0.4 1.2 0.4 2.0 -0.3 -0.3 1.2 0.5 -1.3 2.2 2.1 2.0 1.2
Worrier / anxious feelings 0.1 0.1 0.4 -0.3 -0.6 0.2 -0.2 -0.3 -0.2 0.3 -0.1 0.4 -0.3 -0.2 -0.2 -0.4
Frequency of tiredness / lethargy in last 2 weeks 1.8 2.9 6.7 -1.8 -1.1 0.9 -1.1 -2.6 -2.5 1.7 -0.9 2.5 -2.0 -2.2 -0.4 0.1
Falls in the last year 0.7 0.9 2.1 -1.0 1.1 0.7 0.8 -1.4 -1.4 1.3 -0.2 0.4 0.2 0.2 0.5 1.4
Hair/balding pattern: Pattern 3 0.3 0.5 1.1 0.6 1.0 -0.2 0.0 0.8 0.9 -1.1 0.3 -0.6 0.5 1.0 -0.2 0.5
Number of live births 0.9 1.3 6.1 -2.5 -0.3 -1.5 0.6 -1.5 -1.4 0.7 -1.0 -0.1 -1.0 -0.7 -0.7 0.7
Forced expiratory volume in 1-second (FEV1) 0.1 0.5 1.6 -0.6 -1.3 0.7 -0.3 -0.3 -0.3 0.8 -0.5 0.8 -0.2 -1.0 -0.3 -0.7
Pulse rate 0.7 1.1 4.3 -2.1 0.4 -2.0 0.8 -0.2 -0.1 -0.2 -1.4 -1.1 -0.2 0.3 -1.1 0.9
Happiness 0.3 0.4 1.7 0.1 0.9 -1.3 0.0 0.4 0.5 -0.2 -0.6 -0.9 0.0 0.6 -0.0 -0.5
Noisy workplace 0.7 0.8 2.8 1.7 0.0 0.1 -0.8 1.2 1.3 -1.4 0.9 -0.3 0.2 0.3 -0.1 -0.9
Qualifications: A levels/AS levels or equivalent 0.6 1.4 5.8 0.0 0.1 -1.9 1.2 0.5 0.7 0.4 -1.3 -2.4 1.4 1.3 -0.8 -0.7
Serious illness, injury or assault of a close relative in last 2 years 0.8 1.0 3.7 -1.9 0.1 -0.7 1.3 -0.6 -0.6 0.8 -1.3 -0.9 0.6 0.7 0.3 1.3
Mouth/teeth dental problems: Dentures 0.3 0.5 2.1 -0.2 0.9 1.4 -0.5 -0.5 -0.5 0.4 -0.2 1.2 -0.5 -0.3 0.3 0.3
Asthma 1.4 2.7 4.9 -2.1 -1.6 -1.3 -0.7 -2.2 -1.9 1.1 -2.0 0.8 -2.0 -2.0 -1.5 -1.0
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.8 5.6 -1.5 0.2 -2.0 2.4 -0.6 -0.5 1.3 -0.8 -2.1 1.2 1.1 0.4 1.1
Medication: Cholesterol lowering 1.6 2.5 15.8 -0.0 1.2 -4.0 -0.2 0.7 0.9 -1.7 -0.9 -2.2 -0.8 0.5 -1.7 -1.1
Depression (self-reported) 1.5 1.7 6.0 -2.0 -0.3 -1.0 -0.1 -2.4 -2.3 1.1 -0.1 0.6 -1.5 -1.1 -0.9 0.8
Medication: Lansoprazole 1.6 1.8 4.5 -1.0 -1.2 1.2 -0.3 -1.8 -1.9 1.4 0.5 2.1 -1.4 -1.9 0.2 0.1
Prospective memory result 0.7 0.8 3.2 -0.8 -0.3 -0.6 -0.9 -0.8 -0.8 -0.1 0.7 0.9 -1.8 -1.4 -0.4 -0.8
Lung cancer (father) 0.8 1.0 1.9 -0.4 1.0 1.4 0.0 -1.0 -1.2 0.9 1.3 1.3 -0.5 -0.3 1.2 1.0
Illnesses of mother 0.5 0.6 1.5 -1.0 0.2 -0.1 0.8 -1.1 -1.2 1.2 0.6 0.3 -0.3 -0.2 0.5 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 1.9 0.1 -1.4 0.5 -0.2 -0.2 -0.1 1.0 -0.3 0.3 0.1 -0.7 -0.0 -1.3
Pulse wave Arterial Stiffness index 0.4 0.5 1.5 -0.3 0.3 0.1 1.0 -0.4 -0.3 1.0 -0.8 -0.7 1.2 0.8 0.2 0.7
Impedance of arm (left) 0.5 2.5 12.0 3.5 1.1 0.9 -0.1 1.6 1.5 -0.4 1.5 -0.7 1.9 1.6 1.9 -1.2
Arm fat mass (right) 0.7 2.7 7.1 -0.6 -2.2 0.8 -1.8 -0.3 -0.2 -0.4 -1.4 2.3 -2.3 -2.7 -2.5 -0.8
Trunk predicted mass 0.2 1.3 4.8 -1.9 -1.6 0.0 -0.0 0.2 0.2 -0.3 -2.2 0.4 -0.6 -0.9 -1.9 0.6
Standing height 0.1 0.7 2.7 -0.0 -0.7 1.2 0.8 0.7 0.6 0.4 -1.6 -0.0 1.4 0.6 0.0 0.9
Length of working week for main job 1.1 1.2 4.7 2.2 -0.4 -0.8 -1.4 0.9 1.0 -1.5 0.4 -0.4 -0.7 -0.3 -1.1 -1.6
Exposure to tobacco smoke at home 0.7 0.8 2.8 -1.0 0.1 -0.4 1.0 -1.7 -1.6 1.3 0.3 -0.1 -0.2 0.0 0.9 0.8
Breastfed as a baby 0.4 0.5 1.5 -1.0 0.5 0.1 1.2 0.0 -0.1 0.1 0.4 -0.5 0.8 0.8 0.6 1.1
Tense / ‘highly strung’ 1.9 3.1 10.4 -3.2 0.1 0.5 0.1 -2.6 -2.5 2.1 -1.2 1.9 -1.6 -1.5 -0.7 1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 2.4 3.6 18.7 -4.3 -0.3 -2.4 0.5 -2.1 -1.9 0.9 -1.8 0.0 -1.9 -1.4 -1.9 0.9
Hair/balding pattern: Pattern 4 0.8 1.9 5.7 0.9 -1.2 -0.4 -1.3 1.4 1.5 -1.7 -2.3 0.4 -1.0 -1.0 -2.4 -1.1
Birth weight of first child 0.4 0.7 2.1 -0.7 -1.2 -0.2 -0.6 0.8 0.9 -0.7 -1.2 0.3 -0.6 -1.0 -1.5 -0.5
Peak expiratory flow (PEF) 0.3 0.8 2.9 -1.7 -0.4 0.2 1.3 -0.7 -0.6 1.5 -0.8 -0.4 0.9 0.3 0.1 0.6
Pulse wave reflection index 1.2 1.5 4.5 -0.1 -0.6 1.8 0.9 -1.6 -1.7 2.1 0.9 0.8 0.9 -0.0 1.6 0.8
Ever highly irritable/argumentative for 2 days 1.1 1.4 5.0 -2.2 0.2 -1.6 0.0 -1.8 -1.6 0.2 -0.7 0.1 -1.4 -0.7 -0.8 0.7
Loud music exposure frequency 1.0 1.1 3.4 -1.1 1.1 1.3 -1.0 -0.3 -0.5 -0.8 -0.5 1.8 -1.4 -0.6 -0.8 1.1
Qualifications: O levels/GCSEs or equivalent 1.3 2.0 10.3 -1.0 0.5 -3.2 1.4 -1.0 -0.8 0.6 -1.5 -2.5 0.6 1.2 -0.6 -0.2
Mouth/teeth dental problems: Bleeding gums 0.9 1.1 2.9 1.6 -1.4 1.3 -1.5 0.4 0.5 -0.4 0.1 1.1 -0.2 -1.1 -0.6 -1.7
Blood clot in the leg (DVT) 0.6 0.8 2.2 -0.9 -0.8 -0.1 -0.8 0.2 0.3 -0.5 -1.4 0.7 -1.2 -1.0 -1.5 -0.7
Medication: Paracetamol 1.9 3.1 7.1 -1.2 -1.8 0.4 -1.1 -2.5 -2.4 1.1 0.8 2.4 -2.6 -2.7 -0.9 -0.3
Headache pain in last month 0.1 0.3 1.1 -0.8 -0.3 -0.5 0.1 -0.2 -0.2 0.0 -1.1 0.1 -0.6 -0.4 -0.7 0.3
Medication for cholesterol, blood pressure or diabetes 1.5 2.4 7.5 -0.7 -0.7 2.7 1.6 -1.3 -1.4 2.2 0.3 0.9 1.6 0.5 2.2 1.8
Glaucoma (self-reported) 0.6 0.7 2.3 -0.9 0.6 -0.9 0.8 -1.5 -1.3 1.1 -0.6 -0.6 0.1 0.4 -0.2 0.9
Gout (self-reported) 0.5 0.7 2.0 1.2 -1.1 -0.9 -0.4 0.8 1.0 -0.3 -0.5 -0.7 -0.0 -0.2 -0.6 -1.4
Hypothyroidism/myxoedema (self-reported) 1.3 2.5 5.8 -1.0 1.9 0.9 2.0 -1.5 -1.6 2.1 -0.4 -0.4 1.5 1.6 2.4 1.9
Medication: Amlodipine 1.3 1.8 4.3 1.6 1.3 -1.0 -0.4 2.0 2.1 -1.9 -0.2 -1.7 1.2 1.5 -0.2 -0.5
Medication: Ventolin 100micrograms inhaler 0.8 1.0 7.0 -2.6 -0.7 0.1 0.9 -1.0 -1.0 1.2 -0.5 0.4 -0.2 -0.4 0.3 0.7
Birth weight 0.7 1.6 9.8 0.1 -3.1 1.8 -0.1 -0.5 -0.3 1.2 -1.6 0.9 0.4 -1.3 -0.4 -1.0
Chronic bronchitis/emphysema (mother) 0.4 0.4 1.7 0.9 0.4 1.3 -0.1 0.6 0.5 -0.2 -0.4 0.2 1.0 0.6 0.7 0.1
High blood pressure (siblings) 0.4 0.6 1.3 0.9 -0.3 1.1 -0.9 0.8 0.7 -0.4 1.0 1.1 -0.4 -0.6 -0.2 -0.8
Forced vital capacity (FVC), Best measure 0.2 0.6 2.4 1.0 -1.0 0.6 0.3 -0.2 -0.2 1.5 -0.1 -0.3 1.0 0.1 0.8 -1.3
Body fat percentage 0.7 2.8 7.9 0.0 -1.9 1.1 -1.9 -0.7 -0.6 -0.0 -1.1 2.6 -2.5 -2.8 -2.0 -1.0
Leg fat percentage (right) 1.3 4.6 13.5 -0.4 -2.3 1.1 -2.1 -1.6 -1.5 0.8 -1.4 3.2 -3.2 -3.7 -2.3 -1.1
Arm fat-free mass (right) 0.4 2.2 5.0 -2.2 -2.1 0.9 -0.5 -0.4 -0.3 -0.0 -2.2 1.6 -1.3 -1.9 -2.0 0.6
Exposure to tobacco smoke outside home 0.5 0.7 2.8 -1.7 -1.3 -1.1 -0.0 -0.3 -0.3 0.1 0.2 0.1 -1.0 -1.3 -0.9 0.1
Comparative body size at age 10 0.6 1.7 4.3 -0.1 -0.7 -1.3 -0.9 1.8 1.9 -1.8 -1.5 -0.6 -0.7 -0.3 -2.1 -1.1
Number of full brothers 0.7 0.8 2.4 -0.3 1.0 1.2 0.8 -0.7 -0.8 1.1 1.0 0.2 0.4 0.6 1.6 1.2
Worry too long after embarrassment 1.1 1.8 6.2 0.0 0.5 -0.4 1.2 -2.2 -2.0 2.5 0.4 -0.9 0.9 0.7 1.9 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 3.3 -1.8 -0.0 -1.8 0.2 -1.1 -0.9 0.7 0.2 -0.4 -1.1 -0.5 -0.6 -0.4
Wheeze or whistling in the chest in last year 0.7 1.2 3.2 -1.1 -1.2 -1.0 -0.6 -1.2 -1.2 0.5 -1.1 0.9 -1.8 -1.6 -0.9 -0.5
Number of children fathered 1.1 1.2 4.1 -1.0 0.5 -1.8 1.3 0.4 0.5 0.3 -1.5 -2.0 0.9 1.3 0.0 0.4
Reason for reducing amount of alcohol drunk: Health precaution 1.7 2.0 6.5 -0.7 -1.4 -0.8 -0.7 1.7 1.8 -1.4 -2.5 -0.4 -0.4 -0.7 -2.5 -0.9
Age at first live birth 1.0 1.7 4.5 0.2 1.9 -1.6 1.4 0.5 0.5 -0.3 0.5 -2.1 1.4 2.1 0.3 1.4
Pulse wave peak to peak time 0.4 0.5 1.4 0.3 -0.3 -0.1 -1.0 0.3 0.2 -1.0 0.8 0.7 -1.2 -0.9 -0.2 -0.6
Health satisfaction 1.0 1.3 4.3 -1.0 -0.7 -2.1 -0.9 -0.3 -0.2 -0.3 -0.5 -0.1 -1.9 -1.3 -1.8 -1.4
Shortness of breath walking on level ground 0.3 0.4 1.7 -0.4 0.4 1.2 -0.5 -0.0 -0.1 -0.3 0.4 1.3 -0.4 -0.3 -0.1 0.9
Qualifications: College or University degree 2.0 6.4 17.7 -2.9 2.3 -1.5 4.2 0.1 0.2 1.4 -0.9 -3.4 3.4 3.7 1.3 2.8
Eye problems/disorders: None of the above 0.8 0.9 1.9 -0.3 1.4 -0.4 0.5 1.3 1.1 -1.3 1.2 -0.5 0.5 1.1 0.8 0.9
Mouth/teeth dental problems: Loose teeth 2.0 2.3 6.3 0.8 -0.8 0.0 -2.5 0.5 0.5 -1.4 0.0 1.8 -2.5 -2.1 -1.5 -2.0
Emphysema/chronic bronchitis 0.8 0.9 2.0 -0.3 -0.9 0.5 -0.9 -1.4 -1.3 1.0 -1.2 1.2 -0.9 -1.2 -0.6 -0.5
Medication for pain relief, constipation, heartburn 0.5 0.9 2.5 0.7 0.6 0.4 0.4 1.5 1.4 -0.6 -0.5 -0.9 1.6 1.4 0.8 -0.1
Neck or shoulder pain in last month 0.5 0.7 3.1 -0.4 -1.8 -0.0 -0.7 -0.6 -0.5 0.5 -0.5 0.7 -0.7 -1.4 -0.2 -1.2
Medication: Blood pressure 0.7 1.2 3.2 0.5 -0.2 -0.8 -1.7 0.2 0.3 -1.0 1.1 0.8 -1.8 -1.4 -1.3 -1.5
Angina (self-reported) 0.5 0.7 1.9 -1.3 0.2 -0.6 -0.4 -1.2 -1.1 -0.1 0.1 0.8 -1.4 -0.8 -0.9 0.4
Migraine (self-reported) 0.9 1.2 3.2 0.6 -0.3 -0.0 -1.8 0.6 0.6 -1.8 -1.2 0.8 -1.4 -1.0 -1.4 -0.6
Medication: Ibuprofen 1.1 1.4 4.2 -1.9 0.3 -1.5 2.1 -0.6 -0.6 1.3 -0.3 -1.4 0.8 0.6 0.7 1.2
Medication: Allopurinol 1.1 1.4 3.8 0.8 -1.9 -0.6 -1.3 0.6 0.8 -0.7 -1.2 0.2 -1.0 -1.4 -1.7 -1.8
Medication: Omeprazole 0.9 1.1 3.4 1.2 -1.1 0.6 -1.6 0.8 0.9 -0.8 0.6 0.7 -0.9 -1.1 -0.6 -1.8
Medication: Seretide 50 evohaler 0.4 0.4 1.2 -1.1 -0.8 1.1 -0.1 -0.5 -0.5 -0.1 -0.1 1.0 -0.2 -0.4 -0.6 0.5
Mean time to correctly identify matches 0.4 0.7 2.1 0.2 0.8 0.5 1.1 -0.0 0.1 1.1 0.4 -0.8 1.4 1.3 1.0 0.1
Heart disease (mother) 0.7 0.9 2.5 -0.7 -0.1 -1.5 -1.2 -0.0 0.1 -1.2 -0.0 0.1 -1.6 -0.9 -1.4 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.2 1.0 -1.0 -0.4 -0.2 0.4 0.2 0.2 -0.3 -0.6 0.0 -0.2 -0.2 -0.1 0.5
Whole body fat mass 0.7 2.8 7.5 -0.8 -2.1 1.3 -1.5 -0.7 -0.6 0.0 -1.5 2.6 -2.2 -2.7 -2.2 -0.3
Leg fat mass (right) 1.2 4.7 12.9 -1.2 -3.0 0.9 -1.8 -1.1 -1.0 0.4 -2.2 2.9 -3.0 -3.6 -2.9 -0.8
Arm predicted mass (right) 0.4 2.2 5.3 -1.9 -2.3 1.0 -0.8 -0.2 -0.1 -0.2 -2.3 1.6 -1.2 -1.9 -2.2 0.3
Pulse rate, automated reading 0.3 0.9 4.5 -1.9 0.9 -2.1 0.2 -0.5 -0.3 -0.1 -0.7 -0.6 -1.0 -0.3 -1.0 -0.0
Alcohol intake frequency. 0.4 1.0 2.4 -1.6 -0.0 0.4 -1.0 1.2 1.0 -1.1 -0.7 1.2 -1.4 -1.2 -0.8 -0.4
Comparative height size at age 10 0.1 0.5 1.4 -1.2 -0.8 0.2 0.0 0.9 0.8 -0.6 -1.1 0.3 -0.2 -0.4 -1.0 0.2
Number of full sisters 1.0 1.2 4.8 -2.2 -0.4 0.6 0.7 -1.6 -1.6 1.1 -0.5 0.8 -0.1 -0.5 0.4 1.5
Suffer from ‘nerves’ 0.8 1.3 5.4 -1.0 -1.5 -0.7 0.2 -0.9 -0.7 1.8 -2.3 -0.1 -0.3 -0.9 -1.0 -1.3
Overall health rating 1.4 3.0 9.8 -0.8 -1.5 -0.9 -2.3 -1.0 -0.9 -0.7 -0.5 1.8 -3.1 -2.8 -2.2 -1.6
Chest pain or discomfort 0.2 0.3 1.3 0.1 -0.3 -0.4 -0.8 0.3 0.3 -0.7 -0.5 0.3 -0.7 -0.6 -0.2 -1.1
Had major operations 0.9 1.1 3.0 0.2 0.5 -1.1 1.6 -0.8 -0.6 0.9 0.8 -1.7 1.3 1.3 1.0 0.7
Age at last live birth 0.7 1.1 4.5 1.0 1.3 -1.1 -0.9 0.8 0.8 -2.1 1.6 -0.2 -0.6 0.4 -0.5 0.5
Family relationship satisfaction 0.5 0.6 2.0 0.3 1.1 -1.0 0.5 -0.5 -0.3 0.5 -0.7 -1.4 0.7 1.1 0.6 -0.2
Leg pain on walking 0.2 0.3 1.0 -0.9 -0.1 -1.0 -0.1 -0.3 -0.2 -0.7 0.3 -0.3 -0.5 -0.3 -0.7 0.6
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 3.2 0.3 0.0 -0.5 -1.2 1.1 1.0 -1.8 -0.7 0.3 -1.0 -0.5 -1.3 -0.5
Commuting to job workplace: Car/motor vehicle 2.3 2.6 5.0 -1.9 -2.2 -1.1 -0.1 -1.6 -1.4 1.7 -2.2 0.5 -1.5 -2.0 -1.9 -1.3
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 4.4 0.7 1.9 0.7 0.2 0.4 0.1 -0.2 2.1 0.2 0.4 0.9 1.6 0.5
Medication: Aspirin 0.4 0.5 2.5 0.7 1.5 -0.4 0.0 -0.3 -0.2 -0.5 1.6 -0.2 -0.4 0.3 0.0 0.4
Supplements: Vitamin C 1.0 1.2 5.1 0.0 0.5 1.6 0.9 -0.8 -0.9 1.4 1.3 0.6 0.7 0.4 2.2 0.9
Knee pain experienced in last month 1.5 2.4 7.4 -0.2 -2.7 0.8 -1.7 0.6 0.5 -0.8 -1.3 1.8 -1.6 -2.3 -1.8 -1.6
Hypertension (Self-reported) 0.8 2.2 7.1 1.5 0.0 0.6 -2.3 0.1 0.1 -0.8 2.7 1.7 -2.0 -1.7 -0.6 -1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.4 1.7 0.6 -0.7 0.6 -0.8 0.5 0.5 -0.1 0.4 0.6 -0.6 -0.8 -0.2 -1.3
Illnesses of father: Heart disease 0.5 0.7 2.6 0.3 -1.2 -1.1 0.5 0.1 0.3 0.4 -1.6 -1.1 0.4 0.0 -0.7 -0.9
Illnesses of siblings: Diabetes 2.3 2.9 8.0 0.7 -0.9 0.9 -2.0 2.8 2.8 -2.8 -1.0 0.7 -0.6 -0.9 -2.0 -1.2
Smoking status: Previous 0.4 0.5 1.6 0.2 -1.1 -1.3 0.3 0.3 0.5 -0.1 -1.1 -0.9 0.0 -0.1 -1.2 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 6.6 -1.2 -1.4 0.0 0.3 0.5 0.4 0.2 -2.6 0.1 0.2 -0.5 -0.8 0.3
Whole body fat-free mass 0.3 1.5 5.2 -2.0 -1.7 0.2 -0.0 0.2 0.2 -0.3 -2.3 0.6 -0.6 -1.1 -2.0 0.7
Leg fat-free mass (right) 0.3 1.4 4.3 -2.1 -1.6 0.3 -0.1 0.5 0.5 -0.7 -2.0 0.7 -0.5 -0.9 -2.0 0.8
Arm fat percentage (left) 0.6 2.2 5.8 0.2 -1.7 0.7 -1.9 -0.0 0.1 -0.7 -0.7 2.1 -2.2 -2.4 -2.1 -1.1
Average weekly red wine intake 0.4 0.6 2.4 0.2 -0.5 -0.3 -0.6 0.4 0.5 -0.4 -1.5 -0.1 -0.4 -0.6 -1.3 -1.2
Handedness (chirality/laterality): Left-handed 1.1 1.3 3.1 -0.6 1.0 -1.0 1.8 -0.5 -0.4 0.9 1.3 -1.5 1.0 1.5 1.0 1.4
Mood swings 2.4 4.4 11.3 -2.3 -2.4 0.4 -2.0 -1.8 -1.8 0.5 -1.8 2.8 -3.1 -3.4 -1.5 -1.1
Loneliness, isolation 1.2 1.7 5.2 -1.4 -0.7 1.0 -0.5 -2.3 -2.2 1.2 0.8 1.6 -1.1 -1.3 0.4 0.6
Long-standing illness, disability or infirmity 0.5 0.7 1.8 -1.3 -0.1 0.7 0.1 -1.2 -1.2 0.8 0.6 1.2 -0.7 -0.8 -0.1 0.6
Ever had bowel cancer screening 0.7 0.8 2.0 0.8 1.2 0.1 0.7 0.9 0.9 -0.2 -0.6 -1.1 1.4 1.4 0.5 0.3
Diabetes diagnosed by doctor 0.9 1.5 4.3 -0.1 0.3 -1.9 -0.5 1.3 1.5 -2.0 -1.2 -1.0 -0.6 -0.1 -2.1 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 1.6 1.7 4.0 -1.8 -0.3 -0.5 0.8 -1.8 -1.9 1.5 2.0 0.8 -1.1 -1.0 0.5 1.4
Friendships satisfaction 0.3 0.3 1.0 0.7 0.9 0.7 -0.3 -0.6 -0.6 0.4 0.7 0.3 0.1 0.3 1.0 -0.3
Qualifications: nursing, teaching 1.8 2.8 6.9 -2.6 1.1 -2.6 2.6 -0.3 -0.3 0.9 -1.4 -2.6 1.2 1.6 0.0 1.1
Commuting to job workplace: Walk 1.9 2.0 8.3 0.8 0.4 -0.6 -0.4 2.9 2.7 -2.7 -0.5 -0.9 0.6 0.7 -0.5 -0.2
Eye problems/disorders: Cataract 0.2 0.3 1.4 0.6 -0.5 0.7 0.3 -0.4 -0.4 1.2 -0.2 0.0 0.5 -0.1 0.2 0.0
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 2.7 -0.6 -0.8 1.6 0.0 -0.7 -0.8 1.1 0.1 1.2 0.0 -0.6 0.9 0.1
Medication for cholesterol 1.2 1.8 5.2 -2.1 -0.4 0.6 1.8 -0.7 -0.9 1.6 -2.3 -0.0 0.9 0.3 0.1 2.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 1.3 0.1 -0.3 1.0 -0.6 -0.7 -0.7 0.3 0.9 1.1 -0.5 -0.8 0.2 -0.0
Back pain experienced in last month 0.1 0.1 0.9 -0.1 -0.2 -0.1 0.1 -0.4 -0.4 0.5 -1.0 0.1 -0.1 -0.3 -0.3 -0.0
Mineral and other dietary supplements 0.3 0.4 1.1 -1.1 0.3 0.3 -0.4 -0.0 -0.2 -0.1 -0.8 0.9 -0.9 -0.8 -0.6 0.3
Breast cancer (self-reported) 1.2 1.5 3.4 1.3 1.8 -0.4 -0.7 1.8 1.9 -1.8 1.1 -0.8 0.4 1.2 -0.5 -0.5
Asthma (self-reported) 1.4 2.8 5.8 -2.3 -1.8 -1.7 -0.5 -2.1 -1.8 1.1 -2.4 0.4 -1.9 -1.8 -1.7 -1.1
Osteoporosis (self-reported) 0.3 0.4 1.6 0.1 -0.9 1.2 -0.3 0.8 0.8 -0.1 -0.5 0.6 0.3 -0.5 -0.4 -0.6
Osteoarthritis (self-reported) 0.9 1.2 3.7 -1.9 1.0 -0.5 1.4 -1.1 -1.2 1.0 0.9 -0.5 0.3 0.5 1.0 1.5
Medication: Aspirin 0.4 0.5 2.2 0.2 1.5 -0.1 0.6 -0.6 -0.6 -0.0 1.4 -0.3 -0.0 0.5 0.4 0.9
Medication: Gliclazide 0.3 0.4 2.2 -0.4 0.3 1.5 -0.1 0.2 0.2 -0.2 -0.8 0.9 0.1 -0.2 -0.3 0.9
Illnesses of father: None of the above (group 1) 1.2 1.5 4.8 -0.1 0.5 2.2 0.3 -0.9 -1.0 0.9 2.2 1.3 0.5 0.1 2.0 1.2
Smoking status: Current 0.8 1.2 4.1 0.3 -0.8 0.3 -0.1 -1.9 -1.8 2.0 -0.0 1.1 -0.7 -1.1 0.6 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 1.1 0.8 -0.4 0.4 -1.0 0.6 0.6 -0.4 0.7 0.5 -0.3 -0.6 -0.3 -1.0
Whole body water mass 0.2 1.4 5.2 -2.0 -1.7 0.2 0.0 0.3 0.4 -0.4 -2.3 0.5 -0.5 -0.9 -2.0 0.6
Leg predicted mass (right) 0.2 1.3 4.2 -2.1 -1.6 0.4 -0.0 0.5 0.5 -0.6 -1.9 0.7 -0.5 -0.9 -1.8 0.9
Arm fat mass (left) 0.6 2.5 6.4 -0.6 -2.2 1.1 -1.7 -0.3 -0.2 -0.4 -1.2 2.3 -2.1 -2.5 -2.2 -0.6
Number of self-reported non-cancer illnesses 1.1 1.9 4.7 -1.2 -0.2 -1.4 -1.6 -0.7 -0.5 -0.3 -1.8 0.6 -2.2 -1.5 -2.0 -1.9
Average weekly champagne plus white wine intake 0.5 0.7 4.5 -0.7 -2.1 0.1 0.1 -0.6 -0.6 0.9 -0.4 0.5 -0.4 -1.1 -0.9 -0.3
Miserableness 1.0 1.8 5.4 -2.2 -1.0 -0.6 -0.6 -1.5 -1.4 0.5 -2.3 0.9 -1.6 -1.4 -1.3 -0.3
Guilty feelings 2.3 3.5 12.4 -2.0 -1.0 0.4 1.4 -3.3 -3.2 3.5 -0.5 0.5 0.2 -0.6 1.6 0.8
Wears glasses or contact lenses 1.0 1.2 3.5 -1.9 0.4 0.7 0.3 -1.6 -1.6 1.4 -0.9 1.2 -0.8 -0.5 0.1 1.1
Ever taken oral contraceptive pill 0.3 0.3 0.9 0.4 -0.4 -0.8 -0.6 0.1 0.2 -0.8 -0.1 -0.3 -0.6 -0.3 -0.9 -0.7
Hearing aid user 0.5 0.6 4.2 2.0 -0.7 0.5 -0.6 0.5 0.6 -0.1 -0.2 -0.0 0.2 -0.2 -0.0 -1.2
Mother’s age at death 0.5 0.6 3.4 0.8 0.4 1.8 -0.1 0.6 0.6 0.3 -0.5 0.2 1.3 0.9 0.5 -0.3
Financial situation satisfaction 0.9 1.1 5.3 1.6 -0.1 -1.4 -1.6 0.1 0.2 -0.7 0.7 -0.3 -0.9 -0.2 -0.1 -2.3
Tinnitus: Yes, now most or all of the time 1.0 1.2 3.8 0.5 -1.5 1.4 -1.2 0.3 0.1 -0.4 0.3 1.9 -1.4 -1.8 -0.6 -0.5
Commuting to job workplace: Public transport 0.4 0.5 1.6 0.1 0.7 0.5 0.8 0.4 0.3 0.1 -0.4 -0.5 1.2 1.2 0.7 1.1
Eye problems/disorders: Glaucoma 0.4 0.5 1.2 -0.5 0.7 -0.5 0.7 -1.0 -0.9 0.9 -1.1 -0.5 0.4 0.7 0.1 0.5
Medication: Blood pressure 1.1 2.2 5.9 2.4 0.4 0.5 -2.2 1.4 1.5 -2.0 1.9 0.6 -0.8 -0.5 -0.6 -1.9
Pain type(s) experienced in last month: Hip pain 0.7 0.8 5.2 -0.8 -0.9 -2.3 -0.0 -0.1 0.0 -0.1 0.1 -1.0 -0.8 -0.6 -1.4 -0.5
Supplements: Fish oil (including cod liver oil) 0.4 0.5 2.3 1.0 -0.2 -0.0 0.0 -0.5 -0.5 0.3 1.5 -0.3 0.3 0.4 1.3 -0.3
High cholesterol (Self-reported) 2.4 4.2 16.3 1.0 3.3 -4.0 0.8 0.9 1.1 -1.3 0.1 -3.6 0.9 2.6 0.7 -0.9
Medication: Bendroflumethiazide 1.4 2.1 10.6 0.8 0.0 0.0 -2.1 0.1 0.1 -1.6 3.2 1.3 -2.0 -1.2 -0.5 -1.0
Medication: Paracetamol 2.4 3.7 8.5 -1.8 -1.7 1.0 -0.7 -2.9 -2.9 1.6 1.0 2.6 -2.4 -2.7 -0.4 0.1
Medication: Lisinopril 2.8 3.7 10.9 0.7 -0.9 2.9 -2.9 1.4 1.1 -2.3 1.6 3.3 -1.7 -2.0 -0.4 -0.8
Medication: Atorvastatin 0.6 0.7 3.1 0.0 0.3 -1.8 0.0 -1.4 -1.3 0.6 0.3 -0.5 -1.0 -0.6 0.0 -0.7
Illnesses of father: High blood pressure 0.4 0.5 3.8 0.3 2.0 -1.2 -0.0 -0.1 -0.1 -0.2 0.9 -0.5 -0.6 0.3 -0.2 0.2
Alcohol drinker status: Never 0.8 1.0 4.1 -2.0 0.6 0.6 -0.1 -0.8 -1.0 0.1 0.4 1.1 -1.2 -0.9 -0.1 1.6
Ever smoked 0.7 1.3 6.6 0.0 -2.6 0.4 -0.1 -1.1 -1.0 1.4 -0.8 1.0 -0.7 -1.6 -0.7 -0.7
Basal metabolic rate 0.3 1.8 5.5 -1.9 -2.1 0.3 -0.4 0.1 0.2 -0.3 -2.3 0.9 -0.9 -1.5 -2.2 0.3
Leg fat percentage (left) 1.6 5.8 17.0 -0.6 -2.7 1.4 -2.3 -2.0 -1.9 0.9 -1.0 3.8 -3.6 -4.1 -2.3 -1.0
Arm fat-free mass (left) 0.4 2.2 5.1 -2.0 -2.3 0.6 -0.5 -0.6 -0.5 0.2 -2.3 1.5 -1.4 -1.9 -2.1 0.5
Number of operations (self-reported) 0.9 1.3 3.3 -0.6 1.1 -0.7 1.8 -0.5 -0.5 1.1 1.4 -1.5 1.3 1.5 1.0 1.1
Average weekly beer plus cider intake 0.0 0.0 0.3 0.5 -0.4 -0.1 -0.0 -0.0 -0.1 0.0 -0.1 0.0 0.0 -0.1 0.1 -0.1
Irritability 1.4 2.4 8.1 -2.9 -0.7 -0.8 -0.5 -1.6 -1.6 0.2 -1.1 1.4 -2.3 -2.0 -1.8 0.6
Risk taking 2.2 3.2 8.7 -2.8 0.3 0.1 2.0 -2.9 -2.9 2.8 0.5 0.4 -0.2 -0.4 0.9 2.0
Ever had prostate specific antigen (PSA) test 1.9 2.2 9.1 3.0 -0.4 -0.7 -0.4 1.6 1.8 -0.4 -2.2 -1.6 1.4 0.9 -0.4 -1.9
Fractured/broken bones in last 5 years 1.3 1.7 3.8 -0.9 2.0 -0.0 1.7 0.1 0.0 0.5 -0.9 -1.2 1.7 1.9 1.3 1.9
Age started oral contraceptive pill 1.2 1.4 5.2 -0.3 1.7 1.4 0.2 -0.9 -1.1 0.6 2.3 0.8 0.3 0.5 1.7 1.4
Diastolic blood pressure, automated reading 0.3 0.8 2.2 1.3 1.0 0.1 -1.3 1.1 1.0 -1.5 0.1 0.4 -0.7 -0.1 -0.5 -0.9
Ever depressed for a whole week 0.5 0.6 1.8 -0.8 1.4 -0.0 0.9 -0.1 -0.1 0.1 -0.1 -0.6 0.8 1.1 0.4 1.3
Unable to work because of sickness or disability 1.4 1.8 4.7 -0.8 -1.1 0.7 -1.1 -1.6 -1.4 1.0 0.4 2.0 -2.0 -2.2 -0.7 -0.8
Commuting to job workplace: Cycle 0.3 0.4 1.1 0.3 0.0 1.1 0.4 0.9 0.8 -0.2 -0.0 0.1 0.8 0.6 0.8 0.5
Myopia 0.3 0.5 1.4 0.9 -0.5 1.1 -0.5 0.7 0.6 -0.2 1.2 0.7 -0.2 -0.3 0.0 -0.6
Vascular/heart problems diagnosed by doctor 1.1 3.1 9.4 -0.9 0.6 0.1 2.7 0.5 0.4 0.8 -2.1 -2.1 3.1 2.6 1.5 2.0
Cholesterol lowering medication 1.0 1.5 5.2 2.3 1.0 -0.8 -0.6 0.6 0.7 -1.3 1.8 -1.2 0.5 0.9 1.2 -1.5
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 2.0 0.7 -0.4 0.1 -1.4 0.6 0.6 -0.9 0.5 0.6 -1.1 -0.9 -0.4 -1.4
Pain experienced in last month 1.3 2.2 4.8 0.2 2.0 -0.1 1.5 0.8 0.7 -0.2 1.7 -1.7 2.0 2.2 2.0 1.4
Supplements: Calcium 0.7 0.8 2.7 0.4 0.8 -0.8 0.8 0.8 0.8 -0.1 -0.5 -1.6 1.4 1.5 0.4 -0.2
Basal cell carcinoma (self-reported) 0.8 1.0 2.8 -1.3 1.7 -0.5 1.1 -0.8 -0.9 0.4 0.5 -0.5 0.3 0.8 1.1 1.6
Heart attack/myocardial infarction (self-reported) 1.4 1.9 5.8 0.6 -2.4 0.3 -1.8 0.7 0.7 -0.9 -0.0 1.1 -1.3 -2.2 -1.2 -2.0
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 2.6 -1.0 -0.9 -0.2 -0.6 0.1 0.1 -0.4 -1.6 0.7 -1.2 -1.0 -1.4 -0.5
Heart disease (siblings) 0.4 0.4 2.1 0.3 0.4 0.8 0.3 -0.6 -0.7 0.5 1.4 0.6 -0.1 -0.3 0.5 0.9
Alcohol drinker status: Previous 0.8 0.9 2.8 0.0 -1.2 1.3 -1.1 0.4 0.4 -0.4 -0.8 1.7 -0.9 -1.3 -0.9 -0.6
Pack years of smoking 0.5 0.7 2.0 -0.7 1.1 0.2 -0.6 -1.0 -1.1 0.3 0.3 1.2 -1.4 -0.8 0.2 -0.1
Impedance of whole body 0.3 1.8 10.9 3.3 0.9 1.2 -0.4 0.4 0.3 0.4 1.6 0.2 1.0 0.7 2.0 -1.1
Leg fat mass (left) 1.3 5.1 14.5 -1.3 -3.0 1.1 -1.9 -1.3 -1.2 0.5 -1.9 3.2 -3.2 -3.8 -2.8 -0.7
Arm predicted mass (left) 0.4 2.0 5.8 -2.1 -2.1 0.4 -0.3 -0.4 -0.4 0.2 -2.4 1.1 -1.2 -1.7 -2.1 0.5