Hub : Genes

CCDC93

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0430	0.0170	1.2e-03	0.004	0.026	0.008	0.023	0.010	8.7e-02	3.1e-04	3.0e-02	0.00076	1.8e-02
2	GTEx	Artery Tibial	0.1069	0.0468	7.3e-03	0.015	NA	0.035	NA	0.038	2.1e-02	NA	8.7e-04	NA	6.0e-04
3	GTEx	Brain Cerebellum	0.2460	0.0890	8.4e-03	0.109	NA	0.021	NA	0.075	4.1e-04	NA	7.8e-02	NA	3.1e-03
4	GTEx	Cells Transformed fibroblasts	0.3660	0.0620	6.8e-14	0.099	NA	0.191	NA	0.219	7.5e-08	NA	2.5e-14	NA	2.4e-16
5	GTEx	Heart Atrial Appendage	0.2130	0.0570	2.6e-06	0.250	NA	0.202	NA	0.221	1.4e-11	NA	1.9e-09	NA	2.7e-10
6	GTEx	Heart Left Ventricle	0.1967	0.0533	6.2e-06	0.144	NA	0.105	NA	0.130	4.1e-08	NA	3.2e-06	NA	2.0e-07
7	GTEx	Lung	0.0833	0.0375	8.1e-03	0.040	NA	0.020	NA	0.035	4.9e-04	NA	1.0e-02	NA	9.9e-04
8	ROSMAP	Brain Pre-frontal Cortex	0.0538	0.0198	4.5e-04	0.010	0.027	0.010	0.024	0.002	1.4e-02	1.8e-04	1.7e-02	0.00043	1.5e-01
9	YFS	Blood	0.0158	0.0070	6.2e-03	0.017	0.007	0.011	0.009	0.014	1.8e-06	1.3e-03	1.5e-04	0.00058	1.8e-05
10	TCGA	Breast Invasive Carcinoma	0.0196	0.0119	9.0e-03	0.017	0.013	0.011	NA	0.013	1.7e-04	9.5e-04	2.2e-03	NA	9.4e-04
11	TCGA	Head and Neck Squamous Cell Carcinoma	0.0381	0.0198	7.5e-03	0.010	0.012	0.018	NA	0.014	2.5e-02	1.4e-02	3.5e-03	NA	8.5e-03
12	TCGA	Brain Lower Grade Glioma	0.0665	0.0270	3.9e-05	0.036	0.036	0.035	NA	0.028	5.8e-05	4.9e-05	6.2e-05	NA	3.5e-04
13	TCGA	Lung Squamous Cell Carcinoma	0.0819	0.0337	1.8e-07	0.050	0.079	0.084	NA	0.049	2.0e-06	2.7e-09	9.3e-10	NA	2.8e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.6	1.0	4.3	-2.1	1.1	-0.7	1.0	-1.2	-1.2	0.9	-0.5	-0.2	-0.4	0.5	-0.2	1.1
Bipolar Disorder or Schizophrenia	0.8	1.9	8.6	-1.5	2.9	-1.3	1.7	0.1	0.1	0.1	-0.4	-1.5	0.8	2.0	0.3	1.4
Depressed Affect (Nagel 2018)	1.0	2.0	4.4	-1.7	-0.7	0.0	-1.4	-1.8	-1.6	0.2	-1.7	1.6	-2.1	-1.8	-1.3	-0.3
Depression (Nagel 2018)	1.0	1.5	7.0	-0.2	-0.7	0.9	-0.1	-2.6	-2.4	2.0	-0.2	0.8	-0.1	-0.6	0.3	0.3
Intelligence (Savage-Jansen 2018)	4.2	13.1	36.0	-1.4	3.3	-1.0	6.0	-1.4	-1.4	3.6	0.3	-4.3	5.2	5.1	3.8	4.1
Neuroticism (Nagel 2018)	1.0	2.5	6.2	-2.2	-1.0	-0.6	-0.7	-2.5	-2.3	1.2	-1.3	1.3	-2.0	-1.9	-1.1	-0.3
Schizophrenia (2018)	0.9	2.0	8.4	-0.2	2.9	-1.2	1.3	1.1	1.1	-0.6	-0.1	-1.8	1.3	2.2	0.6	1.0
Schizophrenia vs Biploar Disorder	1.1	1.4	4.0	2.0	0.8	0.7	-1.5	1.8	1.6	-1.8	1.0	0.4	-0.3	-0.1	-0.0	-0.9
Worry (Nagel 2018)	0.7	1.5	3.0	-1.7	-1.2	-0.7	-0.6	-1.4	-1.2	0.8	-1.0	1.0	-1.7	-1.7	-1.4	-0.7
Alzheimer’s Disease (in mother)	1.0	1.2	4.3	0.2	0.4	0.4	1.0	-1.9	-1.7	2.1	-0.1	-0.1	0.8	0.7	1.3	0.7
Alzheimer’s Disease (in father)	1.6	1.7	5.9	-0.4	0.5	0.4	0.6	-2.4	-2.4	1.8	1.5	0.7	-0.4	-0.3	1.4	0.9
Alzheimer’s Disease (including proxy)	1.3	1.9	6.3	0.8	0.5	0.6	0.6	-2.5	-2.4	2.3	1.5	0.5	0.2	0.2	1.8	0.3
Crohns Disease (2017)	0.5	1.1	3.1	-1.0	-0.7	0.8	-1.0	-0.9	-1.0	0.2	1.1	1.8	-1.5	-1.7	-0.1	-0.0
Irritable Bowel Disease (IBD)	0.5	1.2	3.6	-1.9	0.2	-0.1	0.1	-1.7	-1.7	1.1	1.0	1.0	-1.1	-0.9	0.3	0.7
Ulcerative Colitis (UC)	0.6	1.1	2.7	-1.4	0.9	-1.0	1.3	-1.5	-1.5	1.6	0.3	-0.6	0.1	0.5	0.8	0.8
Major Depression (MDD)	2.7	3.3	13.1	-3.6	1.0	0.3	-0.3	-2.1	-2.2	0.2	1.1	2.2	-2.2	-1.5	-0.1	2.3
Reaction Time	0.9	1.6	4.2	-0.0	0.9	0.3	1.9	-0.5	-0.5	1.9	1.1	-1.2	2.0	1.7	1.8	0.2
Verbal and Numeric Reasoning (VNR)	4.4	10.5	30.7	-1.2	2.4	-0.6	5.5	-1.7	-1.7	3.9	-0.1	-3.5	4.6	4.3	3.5	3.5
Breast Cancer	0.8	1.8	7.0	-1.3	-1.7	0.3	1.7	-1.6	-1.6	2.6	0.8	0.1	0.7	-0.4	1.6	0.5
Ovarian Cancer	0.1	0.2	0.9	0.2	0.1	0.6	0.2	0.1	0.0	0.3	1.0	0.2	0.6	0.4	0.6	0.1
Prostate Cancer	0.5	0.8	3.4	-1.8	0.0	-0.4	0.7	-1.1	-1.1	1.2	-1.1	0.2	-0.2	-0.3	0.3	0.4
Age at First Birth	1.6	2.3	7.6	1.5	2.8	-0.7	-0.1	1.6	1.4	-2.1	2.1	-1.3	0.7	1.7	0.5	0.8
Bipolar Disorder (2011)	1.6	1.5	6.7	-1.4	2.5	0.7	1.1	-0.5	-0.7	0.3	0.4	0.5	0.3	1.1	1.0	2.6
Body Mass Index (BMI) (2010)	1.4	1.9	4.3	-0.8	-1.7	-0.8	-1.1	-1.5	-1.3	0.5	-0.8	1.1	-2.1	-2.0	-1.9	-1.1
Coronary Artery Disease (CAD)	2.0	2.4	5.5	-1.0	1.5	-0.4	2.1	-1.5	-1.6	1.6	1.4	-1.1	1.5	1.6	2.3	1.5
Crohns Disease (2012)	0.5	0.8	2.7	-1.6	-0.2	-0.3	-0.9	-0.4	-0.4	-0.4	0.2	0.9	-1.6	-1.2	-1.0	0.1
Mean Putamen Volume	0.4	0.5	1.3	0.6	-0.2	0.4	-1.1	-0.1	-0.1	-0.7	0.5	1.2	-1.2	-0.7	-0.7	-0.1
Fasting Glucose	0.5	0.6	1.9	-1.4	0.8	-1.0	0.6	-0.2	-0.2	0.2	0.3	-1.3	0.3	1.1	0.7	0.1
HbA1C	1.7	1.9	7.2	0.6	0.1	-0.3	1.8	1.0	1.0	0.6	-0.6	-2.3	2.7	2.0	1.2	0.1
HDL Cholesterol	0.5	0.8	2.0	0.6	1.2	0.8	0.1	0.8	0.8	-1.1	-0.8	-0.5	1.0	1.4	-0.2	1.0
LDL Cholesterol	1.7	2.6	12.1	1.6	0.5	-3.5	0.8	0.6	0.8	-0.3	0.0	-3.1	0.9	1.4	1.1	-2.0
Lupus	0.7	1.0	3.2	1.3	0.2	0.4	-1.8	0.5	0.5	-1.4	-0.1	1.1	-1.4	-0.8	-0.8	-0.9
Neuroticism (2016)	0.1	0.2	0.6	-0.7	-0.2	-0.0	-0.1	-0.5	-0.6	-0.1	0.2	0.8	-0.5	-0.5	-0.3	0.3
Primary Biliary Cirrhosis	1.0	1.4	4.5	-1.9	1.0	-0.5	1.4	-0.7	-0.7	0.7	-2.1	-0.7	0.6	0.8	0.0	2.1
Rheumatoid Arthritis	0.2	0.3	1.3	-0.6	-0.5	-0.0	0.6	-0.9	-0.9	1.2	-0.5	0.0	0.1	-0.1	0.1	0.3
Schizophrenia (2014)	0.2	0.5	3.0	0.0	1.7	-0.3	-0.0	0.8	0.7	-0.8	0.6	-0.3	0.0	0.7	-0.1	0.3
Triglycerides	0.5	0.9	3.2	-0.6	-1.8	-1.0	-0.4	0.1	0.2	0.5	-0.3	0.1	-0.9	-1.4	-1.1	-1.6
Type 2 Diabetes (T2D) (2012)	1.3	1.5	4.1	-0.1	-0.3	-1.4	0.8	2.0	2.0	-1.0	-1.5	-1.8	1.0	0.9	-0.8	-0.3
Ulcerative Colitis	0.9	1.4	6.2	-2.5	0.4	-1.0	1.0	-1.6	-1.6	0.9	-0.1	0.1	-0.6	-0.1	-0.3	1.8
Blood Eosinophil Count	0.1	0.6	1.8	-1.0	-1.0	-0.2	0.6	-1.2	-1.1	1.3	-0.5	0.2	-0.1	-0.6	-0.2	-0.0
Blood Platelet Count	0.1	0.8	3.9	-0.6	0.3	-2.0	0.7	0.7	0.7	-0.5	-0.8	-1.5	0.1	0.3	-1.0	-0.1
Blood Red Count	0.2	1.6	5.5	-1.9	1.3	-0.7	1.5	0.2	0.2	0.7	-2.3	-1.2	1.0	1.2	-0.0	1.6
Blood White Count	0.2	1.8	4.8	-1.5	-1.6	0.3	0.4	-2.2	-2.1	2.1	0.3	1.1	-1.0	-1.6	0.1	-0.1
Heel T-Score	1.0	8.3	58.2	7.6	-0.1	1.2	-3.9	0.8	0.6	-2.4	2.1	1.9	-2.0	-1.3	1.8	-3.1
BMI	0.7	4.2	9.5	-2.5	-2.7	-0.1	-0.9	-1.7	-1.5	0.7	-2.0	2.1	-2.8	-3.1	-3.0	-0.1
Height	0.1	1.1	3.0	-0.2	-0.4	1.7	1.2	0.5	0.4	0.5	-1.6	-0.1	1.6	0.9	0.1	1.6
Waist Hip Ratio (WHR)	0.5	2.3	7.6	1.0	2.8	-0.7	0.8	1.6	1.5	-1.4	2.1	-1.5	1.0	1.9	0.8	0.9
Systolic Blood Pressure	0.3	1.7	3.7	1.9	0.6	1.4	-1.9	1.2	1.0	-1.8	1.9	1.5	-1.0	-0.7	-0.2	-0.5
Smoking Status	1.5	3.5	12.8	-1.4	-1.7	-0.8	1.1	-3.6	-3.4	3.4	-0.4	0.7	-0.9	-1.4	0.3	0.3
Allergy or Eczema	0.4	1.0	3.6	-1.9	-0.4	-1.8	-0.2	-0.9	-0.8	0.0	-0.6	0.2	-1.3	-0.9	-1.2	-0.4
Cardiovascular Disease	0.4	1.5	5.4	0.4	-0.3	-2.0	-1.4	-0.4	-0.2	-0.3	1.0	-0.1	-2.0	-1.4	-0.8	-2.3
Hypothyroidism (self reported)	1.2	2.7	4.9	-1.0	1.8	1.2	2.2	-1.2	-1.2	1.9	-0.9	-0.5	2.0	1.9	2.2	2.1
Respiratory disease	1.2	2.7	8.4	-2.0	-1.0	-1.6	0.3	-2.5	-2.1	2.1	-2.9	-0.4	-0.8	-0.8	-1.3	-0.9
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.9	-1.4	0.7	-0.9	-0.0	-0.6	-0.6	-0.3	0.2	0.3	-1.2	-0.6	-0.9	0.8
Lung FEV1/FVC ratio	0.2	0.9	5.4	-2.3	0.4	-0.6	0.5	-0.5	-0.8	0.1	1.0	0.5	-1.0	-0.5	0.3	1.6
Lung FVC	0.1	0.7	3.8	0.8	-1.6	0.2	-0.4	-0.0	0.1	0.8	-0.2	-0.1	0.3	-0.7	-0.2	-2.0
Neuroticism	1.2	2.9	7.2	-2.7	-1.3	-1.4	-0.3	-2.5	-2.3	1.4	-1.7	0.8	-2.0	-1.9	-1.1	-0.5
Chronotype (morning person)	0.5	1.1	4.9	-0.1	-1.5	1.7	-0.1	-0.1	-0.3	0.1	2.2	1.3	-0.3	-1.2	0.2	0.6
Hair Pigment	0.1	2.3	5.8	-1.7	0.9	-2.4	1.3	-1.8	-1.8	1.7	2.4	-1.2	-0.6	-0.0	1.5	0.2
Tanning	0.2	2.5	6.6	2.6	-0.7	2.3	-1.6	2.1	1.9	-1.9	1.8	1.7	0.1	-0.7	-0.2	-0.8
Hand grip strength (left)	1.4	3.6	10.9	-1.5	-2.9	0.8	-1.7	-0.9	-0.9	0.2	-0.5	2.7	-2.7	-3.3	-2.0	-0.9
Number of treatments/medications taken	0.3	0.5	1.4	-1.2	-0.3	-0.1	0.4	-1.1	-0.9	1.2	-0.4	0.2	-0.3	-0.6	-0.6	0.1
Average weekly spirits intake	0.8	1.0	2.5	0.1	-0.8	-1.5	-0.8	0.3	0.5	-0.6	-1.5	-0.4	-1.0	-0.7	-1.6	-1.5
Sensitivity / hurt feelings	0.5	0.8	2.7	-0.5	-0.6	-0.4	-0.8	-1.0	-0.9	0.6	-1.6	0.6	-1.4	-1.1	-0.6	-0.9
Frequency of depressed mood in last 2 weeks	1.4	2.0	6.7	-1.7	-0.4	0.9	0.4	-2.6	-2.4	2.3	-1.4	0.9	-0.1	-0.6	0.4	0.8
Hearing difficulty/problems: Yes	0.3	0.5	1.7	-0.3	1.3	-0.5	0.6	-0.7	-0.8	0.1	0.7	-0.2	-0.2	0.5	0.6	1.3
Relative age of first facial hair	0.4	0.8	2.4	-0.3	0.1	1.2	1.0	0.2	0.0	0.5	1.2	0.1	1.3	0.9	1.6	1.2
Other serious medical condition/disability diagnosed by doctor	1.0	1.4	5.5	-1.1	-2.3	-1.4	-0.2	-0.2	-0.0	0.2	-1.3	-0.1	-0.9	-1.4	-1.6	-1.4
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.3	0.5	-1.5	0.1	-0.9	-0.5	-0.2	0.3	-1.5	0.6	-0.7	-1.2	-1.2	-1.4
Ever had hysterectomy (womb removed)	0.7	0.8	4.0	-2.0	0.7	0.5	0.5	-0.7	-0.9	0.3	0.2	0.9	-0.5	-0.4	0.5	1.6
Systolic blood pressure, automated reading	0.6	1.6	4.9	2.2	1.2	0.6	-1.3	1.9	1.8	-2.0	1.1	0.2	-0.3	0.4	-0.2	-0.4
Eye problems/disorders: Diabetes related eye disease	2.1	2.3	5.2	1.2	-2.0	0.7	-2.3	0.9	0.9	-1.2	-0.9	1.7	-1.5	-1.9	-1.7	-1.7
Angina	0.7	0.9	2.8	-1.5	0.4	-0.7	-0.5	-1.3	-1.2	-0.2	0.2	0.9	-1.7	-1.0	-1.0	0.6
Medication for hormone replacement therapy	0.9	1.0	3.5	-1.9	-0.4	-1.4	0.3	-1.4	-1.2	0.8	-0.9	-0.1	-1.0	-0.6	-0.7	-0.3
Vitamin and mineral supplements	2.7	3.7	8.0	0.9	-2.0	-0.9	-2.8	1.0	1.0	-2.0	-0.4	1.4	-2.7	-2.6	-2.5	-2.3
Supplements: Zinc	0.8	0.9	2.3	-0.4	1.5	1.0	1.2	-0.4	-0.4	0.7	0.7	-0.1	1.0	1.1	1.1	1.4
Medication: Co-codamol	1.7	2.0	9.9	0.1	-1.6	-0.9	-0.7	0.9	1.1	-0.2	-3.1	-0.5	-0.2	-0.6	-2.1	-2.2
Medication: Metformin	0.8	1.2	3.6	0.4	0.4	-1.5	-0.4	1.6	1.6	-1.9	-0.8	-1.0	-0.2	0.1	-1.1	-0.6
Diabetes (father)	3.7	4.6	10.8	0.4	-1.2	-1.6	-1.6	3.2	3.3	-3.0	-2.2	-0.7	-0.9	-0.7	-3.3	-2.4
Diabetes (mother)	1.6	2.0	4.9	2.0	0.1	-0.5	-1.8	2.0	2.1	-2.0	-0.0	-0.3	-0.5	-0.2	-0.9	-2.2
Severe depression (siblings)	1.9	2.2	4.4	2.1	-1.1	0.0	-2.1	1.5	1.6	-1.8	1.7	0.8	-1.1	-0.9	-1.1	-1.9
Pack years adult smoking proportion	0.3	0.4	1.2	-0.7	0.9	0.0	-0.4	-0.8	-0.9	0.4	0.0	0.9	-1.1	-0.6	0.2	-0.2
Impedance of leg (right)	0.3	1.3	8.1	2.8	0.4	0.8	-0.3	-0.7	-0.7	1.3	0.7	0.4	0.4	0.1	1.6	-1.4
Leg fat-free mass (left)	0.3	1.4	5.5	-1.9	-1.6	0.1	-0.0	0.6	0.6	-0.7	-2.4	0.4	-0.4	-0.8	-2.1	0.7
Trunk fat percentage	0.6	2.3	5.6	0.5	-1.6	1.1	-1.9	-0.2	-0.1	-0.4	-1.2	2.3	-2.0	-2.4	-1.9	-1.0
Hand grip strength (right)	0.4	1.0	2.4	-1.4	-1.3	0.4	-0.6	0.3	0.2	-0.2	-0.8	1.2	-1.2	-1.6	-1.5	-0.1
Townsend deprivation index at recruitment	0.4	0.6	2.8	-0.2	-0.9	1.5	0.1	0.3	0.3	-0.2	-1.7	0.7	0.4	-0.3	0.1	0.6
Current tobacco smoking	0.6	1.0	4.5	0.2	-0.7	0.3	0.2	-1.7	-1.7	2.1	-0.1	0.8	-0.3	-0.8	0.8	-0.6
Average weekly fortified wine intake	0.4	0.5	1.6	-0.2	0.9	-0.7	0.7	0.0	0.1	-0.1	-1.3	-1.1	0.8	1.1	0.2	0.3
Maternal smoking around birth	0.5	0.7	5.3	1.3	0.8	-0.5	0.2	-0.2	-0.2	-0.2	2.3	-0.6	0.2	0.4	1.0	0.0
Fed-up feelings	0.7	1.3	9.1	-0.3	-0.9	-0.3	-0.8	-0.6	-0.5	0.4	-3.0	0.5	-0.9	-1.1	-1.4	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	2.7	3.6	13.7	-0.9	-0.8	1.3	0.1	-3.7	-3.5	3.3	1.0	1.6	-0.6	-1.1	1.1	0.5
Relative age voice broke	0.2	0.4	1.1	0.2	-0.9	0.3	0.4	1.0	1.0	-0.1	-0.9	-0.4	0.7	0.3	-0.1	-0.3
Taking other prescription medications	0.5	0.8	2.0	-0.8	-1.1	-0.3	-0.7	-0.1	-0.0	-0.2	-1.2	0.7	-1.2	-1.3	-1.4	-0.9
Age when periods started (menarche)	0.2	0.4	1.0	-0.8	-0.3	0.5	0.4	-0.5	-0.6	1.0	-0.8	0.8	-0.2	-0.7	0.1	0.7
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	6.4	-2.1	0.4	0.6	1.5	-0.3	-0.5	0.3	-1.3	0.0	0.6	0.8	0.4	2.5
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	8.8	3.0	-1.0	0.4	-2.5	0.4	0.4	-1.4	0.6	1.7	-2.3	-2.0	-0.8	-1.8
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	2.7	1.2	-0.1	1.2	-1.6	-0.1	-0.2	-0.2	0.7	1.6	-1.3	-1.1	-0.6	-0.6
Qualifications: CSEs or equivalent	0.8	1.0	2.6	0.9	-1.3	-0.2	-1.6	0.0	-0.0	-0.9	-0.5	0.9	-1.3	-1.4	-0.3	-1.5
Serious illness, injury or assault to yourself	0.5	0.6	2.0	-1.4	-0.7	-0.7	-0.1	-0.9	-0.8	0.7	-0.2	0.1	-0.8	-0.8	-0.7	-0.5
High blood pressure	1.1	3.0	7.9	1.8	-0.3	0.4	-2.8	0.6	0.6	-1.3	2.3	1.8	-2.4	-2.0	-1.3	-2.2
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.1	-1.2	-1.1	-0.5	-0.8	-0.8	-0.8	-0.3	0.3	0.9	-1.4	-1.4	-0.6	-0.5
Multivitamins +/- minerals	1.4	1.8	4.6	-0.4	1.4	0.2	2.0	-0.5	-0.5	0.9	0.8	-1.4	2.0	2.1	1.7	1.3
Stomach or abdominal pain in last month	0.3	0.4	1.0	-0.8	0.2	0.2	-0.6	-1.0	-0.9	0.3	-0.4	0.8	-0.9	-0.4	-0.6	0.2
Supplements: Glucosamine	1.3	1.7	5.6	-0.8	-0.0	0.5	2.1	-0.5	-0.3	1.2	-0.5	-1.4	2.4	1.9	0.9	1.6
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.8	-0.7	-1.2	0.3	-0.7	-0.5	-0.5	0.0	0.2	1.2	-1.2	-1.4	-0.4	-0.1
Medication: Atenolol	0.6	0.7	2.3	0.6	-0.3	0.6	-1.5	0.1	0.1	-0.3	-0.6	1.2	-1.1	-1.0	-1.1	-1.0
Medication: Levothyroxine sodium	1.3	2.2	6.2	-0.5	2.0	2.3	1.3	-0.6	-0.8	1.0	0.9	0.5	1.3	1.4	2.5	2.2
Sitting height	0.2	1.1	3.9	1.4	0.1	0.8	1.2	0.0	0.1	1.2	-0.9	-0.8	2.0	1.5	1.1	0.5
Chronic bronchitis/emphysema (father)	1.7	2.0	5.9	0.2	-0.3	0.7	-2.4	0.1	0.0	-1.7	0.3	2.3	-2.3	-1.9	-1.4	-0.6
High blood pressure (mother)	0.5	0.7	2.3	0.1	1.2	0.4	0.2	1.5	1.4	-1.1	0.0	-0.6	0.8	1.1	0.1	0.2
Body mass index (BMI)	0.8	3.4	9.1	-1.6	-2.5	0.4	-1.6	-0.8	-0.7	-0.2	-1.6	2.3	-2.7	-3.0	-2.8	-0.6
Impedance of leg (left)	0.3	1.5	6.8	2.6	-0.1	1.2	-0.6	-1.0	-1.0	1.4	1.1	1.1	-0.1	-0.5	1.7	-1.4
Leg predicted mass (left)	0.3	1.4	5.4	-1.8	-1.6	0.1	-0.0	0.7	0.7	-0.8	-2.3	0.3	-0.3	-0.7	-2.1	0.7
Trunk fat mass	0.6	2.6	6.5	-0.4	-1.9	1.0	-1.7	-0.3	-0.2	-0.4	-1.7	2.4	-2.2	-2.5	-2.3	-0.5
Waist circumference	0.4	1.6	4.9	-1.3	-1.9	0.4	-0.9	0.2	0.2	-0.4	-1.2	1.4	-1.5	-2.0	-2.2	-0.3
Number of incorrect matches in round	0.3	0.6	1.6	-1.1	1.3	-0.1	-0.3	-0.3	-0.4	-0.4	0.6	0.7	-1.1	-0.2	-0.4	1.3
Past tobacco smoking	0.6	1.0	4.8	-0.5	2.2	0.9	0.4	0.5	0.3	-0.5	1.1	-0.1	0.9	1.3	1.4	1.1
Alcohol usually taken with meals	0.4	0.6	2.1	0.4	-0.2	-0.7	1.0	0.5	0.6	0.3	-1.0	-1.5	1.2	1.1	0.1	0.0
Nervous feelings	0.2	0.3	1.2	-1.1	-0.2	-0.2	-0.4	-0.3	-0.3	0.3	-0.3	0.7	-0.9	-0.8	-0.7	-0.1
Frequency of tenseness / restlessness in last 2 weeks	1.9	2.9	5.9	-1.4	-2.0	1.6	-0.6	-2.4	-2.3	2.2	-0.6	2.4	-1.4	-2.2	-0.5	-0.0
Hearing difficulty/problems with background noise	0.2	0.3	0.8	0.6	0.1	-0.2	-0.8	0.4	0.3	-0.7	0.2	0.6	-0.9	-0.6	-0.1	-0.3
Hair/balding pattern: Pattern 2	0.3	0.4	1.3	-0.5	0.1	-0.1	0.1	-0.8	-0.8	0.6	1.1	-0.0	-0.2	-0.3	1.1	-0.5
Had menopause	0.4	0.5	1.6	0.9	0.0	1.0	-1.3	0.3	0.3	-0.7	0.0	0.9	-0.7	-0.8	-0.2	-0.7
Had other major operations	0.7	0.8	5.5	0.6	-0.4	0.9	-0.4	-0.7	-0.7	0.8	2.3	0.7	-0.4	-0.7	0.6	-0.8
Forced vital capacity (FVC)	0.1	0.3	0.9	0.3	-0.9	0.7	0.2	-0.0	-0.0	0.9	-0.6	0.0	0.7	-0.1	0.3	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	1.7	3.8	10.6	3.2	-1.0	1.4	-3.0	0.7	0.6	-2.0	1.3	2.6	-2.5	-2.2	-0.7	-1.4
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.3	-1.0	1.5	1.0	0.7	-1.2	-1.3	1.3	1.0	0.7	0.3	0.6	1.2	1.3
Qualifications: None of the above	2.3	4.9	12.6	2.0	-1.6	2.7	-3.5	1.5	1.3	-1.9	0.6	3.2	-2.3	-2.7	-1.3	-2.4
Financial difficulties in last 2 years	0.2	0.3	1.3	0.6	-0.5	0.0	0.6	-0.0	0.1	0.2	-0.8	-0.9	1.1	0.6	0.1	0.0
Mouth/teeth dental problems	0.9	1.4	3.8	-1.0	1.1	-1.6	1.7	0.4	0.3	-0.4	-0.1	-1.7	1.1	1.6	0.2	2.0
Heart attack	1.2	1.5	4.8	0.5	-2.2	0.3	-1.6	0.5	0.5	-0.8	0.0	1.1	-1.2	-2.1	-1.0	-1.8
Allergy	1.3	3.0	6.9	2.0	2.2	1.2	1.3	1.7	1.5	-0.5	1.2	-1.4	2.5	2.6	1.6	1.5
Pain all over the body in last month	1.2	1.2	5.6	2.4	-0.5	1.2	-1.2	-0.8	-0.6	0.6	0.2	1.3	-0.6	-0.8	-0.0	-1.8
Diabetes (self-reported)	0.7	1.0	2.6	-0.4	-0.1	-1.4	0.2	1.3	1.4	-1.5	-1.2	-1.1	0.1	0.2	-1.6	0.1
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	5.1	-1.1	-0.7	1.9	-0.3	-1.6	-1.7	1.4	0.3	2.3	-0.8	-1.3	0.5	0.5
Medication: Ramipril	0.6	0.8	2.9	0.1	1.2	1.1	-0.7	-0.5	-0.7	-0.3	1.7	1.3	-0.8	-0.2	0.9	0.7
Medication: Simvastatin	2.3	3.3	11.7	0.7	2.3	-3.4	-0.2	1.5	1.7	-2.6	-0.9	-2.8	0.3	1.7	-1.0	-0.9
Fluid intelligence score	4.3	8.8	29.2	-1.7	1.6	-1.0	5.4	-0.8	-0.8	3.5	-0.7	-3.8	4.6	3.9	2.7	2.8
Illnesses of siblings	0.3	0.5	1.8	-0.1	0.5	-1.1	0.6	0.1	0.1	-0.2	-1.1	-1.3	0.7	1.0	0.2	0.1
Neuroticism score	0.9	1.9	4.5	-2.1	-1.1	-0.7	-0.2	-2.0	-1.9	1.5	-1.8	0.8	-1.4	-1.5	-0.7	-0.3
Weight	0.6	3.1	7.3	-1.5	-2.7	1.0	-1.3	-0.4	-0.3	-0.1	-2.1	2.2	-2.0	-2.7	-2.6	-0.2
Impedance of arm (right)	0.7	3.1	12.2	3.5	1.4	0.3	0.6	1.6	1.6	-0.1	1.4	-1.6	2.4	2.2	2.1	-1.1
Arm fat percentage (right)	0.5	1.9	5.1	0.2	-1.6	0.3	-1.7	-0.1	-0.0	-0.5	-0.6	1.8	-2.1	-2.3	-2.0	-1.1
Trunk fat-free mass	0.2	1.2	4.8	-1.9	-1.6	0.0	-0.0	0.2	0.2	-0.2	-2.2	0.4	-0.6	-0.9	-1.9	0.6
Hip circumference	0.7	2.9	7.7	-1.5	-2.8	1.7	-0.7	-0.9	-0.9	0.8	-2.1	2.4	-1.4	-2.4	-2.0	0.2
Time employed in main current job	1.7	2.0	5.3	0.8	-0.1	-1.1	-1.9	1.5	1.5	-2.0	-0.8	0.5	-1.8	-1.1	-2.3	-1.2
Alcohol intake versus 10 years previously	0.3	0.4	1.8	0.1	0.3	0.4	-0.2	1.4	1.2	-1.0	0.4	0.0	0.4	0.1	0.2	0.0
Father’s age at death	1.4	1.9	5.0	-0.4	1.2	0.4	2.0	-0.3	-0.3	1.2	0.5	-1.3	2.2	2.1	2.0	1.2
Worrier / anxious feelings	0.1	0.1	0.4	-0.3	-0.6	0.2	-0.2	-0.3	-0.2	0.3	-0.1	0.4	-0.3	-0.2	-0.2	-0.4
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	6.7	-1.8	-1.1	0.9	-1.1	-2.6	-2.5	1.7	-0.9	2.5	-2.0	-2.2	-0.4	0.1
Falls in the last year	0.7	0.9	2.1	-1.0	1.1	0.7	0.8	-1.4	-1.4	1.3	-0.2	0.4	0.2	0.2	0.5	1.4
Hair/balding pattern: Pattern 3	0.3	0.5	1.1	0.6	1.0	-0.2	0.0	0.8	0.9	-1.1	0.3	-0.6	0.5	1.0	-0.2	0.5
Number of live births	0.9	1.3	6.1	-2.5	-0.3	-1.5	0.6	-1.5	-1.4	0.7	-1.0	-0.1	-1.0	-0.7	-0.7	0.7
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.6	-0.6	-1.3	0.7	-0.3	-0.3	-0.3	0.8	-0.5	0.8	-0.2	-1.0	-0.3	-0.7
Pulse rate	0.7	1.1	4.3	-2.1	0.4	-2.0	0.8	-0.2	-0.1	-0.2	-1.4	-1.1	-0.2	0.3	-1.1	0.9
Happiness	0.3	0.4	1.7	0.1	0.9	-1.3	0.0	0.4	0.5	-0.2	-0.6	-0.9	0.0	0.6	-0.0	-0.5
Noisy workplace	0.7	0.8	2.8	1.7	0.0	0.1	-0.8	1.2	1.3	-1.4	0.9	-0.3	0.2	0.3	-0.1	-0.9
Qualifications: A levels/AS levels or equivalent	0.6	1.4	5.8	0.0	0.1	-1.9	1.2	0.5	0.7	0.4	-1.3	-2.4	1.4	1.3	-0.8	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	3.7	-1.9	0.1	-0.7	1.3	-0.6	-0.6	0.8	-1.3	-0.9	0.6	0.7	0.3	1.3
Mouth/teeth dental problems: Dentures	0.3	0.5	2.1	-0.2	0.9	1.4	-0.5	-0.5	-0.5	0.4	-0.2	1.2	-0.5	-0.3	0.3	0.3
Asthma	1.4	2.7	4.9	-2.1	-1.6	-1.3	-0.7	-2.2	-1.9	1.1	-2.0	0.8	-2.0	-2.0	-1.5	-1.0
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	5.6	-1.5	0.2	-2.0	2.4	-0.6	-0.5	1.3	-0.8	-2.1	1.2	1.1	0.4	1.1
Medication: Cholesterol lowering	1.6	2.5	15.8	-0.0	1.2	-4.0	-0.2	0.7	0.9	-1.7	-0.9	-2.2	-0.8	0.5	-1.7	-1.1
Depression (self-reported)	1.5	1.7	6.0	-2.0	-0.3	-1.0	-0.1	-2.4	-2.3	1.1	-0.1	0.6	-1.5	-1.1	-0.9	0.8
Medication: Lansoprazole	1.6	1.8	4.5	-1.0	-1.2	1.2	-0.3	-1.8	-1.9	1.4	0.5	2.1	-1.4	-1.9	0.2	0.1
Prospective memory result	0.7	0.8	3.2	-0.8	-0.3	-0.6	-0.9	-0.8	-0.8	-0.1	0.7	0.9	-1.8	-1.4	-0.4	-0.8
Lung cancer (father)	0.8	1.0	1.9	-0.4	1.0	1.4	0.0	-1.0	-1.2	0.9	1.3	1.3	-0.5	-0.3	1.2	1.0
Illnesses of mother	0.5	0.6	1.5	-1.0	0.2	-0.1	0.8	-1.1	-1.2	1.2	0.6	0.3	-0.3	-0.2	0.5	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.9	0.1	-1.4	0.5	-0.2	-0.2	-0.1	1.0	-0.3	0.3	0.1	-0.7	-0.0	-1.3
Pulse wave Arterial Stiffness index	0.4	0.5	1.5	-0.3	0.3	0.1	1.0	-0.4	-0.3	1.0	-0.8	-0.7	1.2	0.8	0.2	0.7
Impedance of arm (left)	0.5	2.5	12.0	3.5	1.1	0.9	-0.1	1.6	1.5	-0.4	1.5	-0.7	1.9	1.6	1.9	-1.2
Arm fat mass (right)	0.7	2.7	7.1	-0.6	-2.2	0.8	-1.8	-0.3	-0.2	-0.4	-1.4	2.3	-2.3	-2.7	-2.5	-0.8
Trunk predicted mass	0.2	1.3	4.8	-1.9	-1.6	0.0	-0.0	0.2	0.2	-0.3	-2.2	0.4	-0.6	-0.9	-1.9	0.6
Standing height	0.1	0.7	2.7	-0.0	-0.7	1.2	0.8	0.7	0.6	0.4	-1.6	-0.0	1.4	0.6	0.0	0.9
Length of working week for main job	1.1	1.2	4.7	2.2	-0.4	-0.8	-1.4	0.9	1.0	-1.5	0.4	-0.4	-0.7	-0.3	-1.1	-1.6
Exposure to tobacco smoke at home	0.7	0.8	2.8	-1.0	0.1	-0.4	1.0	-1.7	-1.6	1.3	0.3	-0.1	-0.2	0.0	0.9	0.8
Breastfed as a baby	0.4	0.5	1.5	-1.0	0.5	0.1	1.2	0.0	-0.1	0.1	0.4	-0.5	0.8	0.8	0.6	1.1
Tense / ‘highly strung’	1.9	3.1	10.4	-3.2	0.1	0.5	0.1	-2.6	-2.5	2.1	-1.2	1.9	-1.6	-1.5	-0.7	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.6	18.7	-4.3	-0.3	-2.4	0.5	-2.1	-1.9	0.9	-1.8	0.0	-1.9	-1.4	-1.9	0.9
Hair/balding pattern: Pattern 4	0.8	1.9	5.7	0.9	-1.2	-0.4	-1.3	1.4	1.5	-1.7	-2.3	0.4	-1.0	-1.0	-2.4	-1.1
Birth weight of first child	0.4	0.7	2.1	-0.7	-1.2	-0.2	-0.6	0.8	0.9	-0.7	-1.2	0.3	-0.6	-1.0	-1.5	-0.5
Peak expiratory flow (PEF)	0.3	0.8	2.9	-1.7	-0.4	0.2	1.3	-0.7	-0.6	1.5	-0.8	-0.4	0.9	0.3	0.1	0.6
Pulse wave reflection index	1.2	1.5	4.5	-0.1	-0.6	1.8	0.9	-1.6	-1.7	2.1	0.9	0.8	0.9	-0.0	1.6	0.8
Ever highly irritable/argumentative for 2 days	1.1	1.4	5.0	-2.2	0.2	-1.6	0.0	-1.8	-1.6	0.2	-0.7	0.1	-1.4	-0.7	-0.8	0.7
Loud music exposure frequency	1.0	1.1	3.4	-1.1	1.1	1.3	-1.0	-0.3	-0.5	-0.8	-0.5	1.8	-1.4	-0.6	-0.8	1.1
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	10.3	-1.0	0.5	-3.2	1.4	-1.0	-0.8	0.6	-1.5	-2.5	0.6	1.2	-0.6	-0.2
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	2.9	1.6	-1.4	1.3	-1.5	0.4	0.5	-0.4	0.1	1.1	-0.2	-1.1	-0.6	-1.7
Blood clot in the leg (DVT)	0.6	0.8	2.2	-0.9	-0.8	-0.1	-0.8	0.2	0.3	-0.5	-1.4	0.7	-1.2	-1.0	-1.5	-0.7
Medication: Paracetamol	1.9	3.1	7.1	-1.2	-1.8	0.4	-1.1	-2.5	-2.4	1.1	0.8	2.4	-2.6	-2.7	-0.9	-0.3
Headache pain in last month	0.1	0.3	1.1	-0.8	-0.3	-0.5	0.1	-0.2	-0.2	0.0	-1.1	0.1	-0.6	-0.4	-0.7	0.3
Medication for cholesterol, blood pressure or diabetes	1.5	2.4	7.5	-0.7	-0.7	2.7	1.6	-1.3	-1.4	2.2	0.3	0.9	1.6	0.5	2.2	1.8
Glaucoma (self-reported)	0.6	0.7	2.3	-0.9	0.6	-0.9	0.8	-1.5	-1.3	1.1	-0.6	-0.6	0.1	0.4	-0.2	0.9
Gout (self-reported)	0.5	0.7	2.0	1.2	-1.1	-0.9	-0.4	0.8	1.0	-0.3	-0.5	-0.7	-0.0	-0.2	-0.6	-1.4
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	5.8	-1.0	1.9	0.9	2.0	-1.5	-1.6	2.1	-0.4	-0.4	1.5	1.6	2.4	1.9
Medication: Amlodipine	1.3	1.8	4.3	1.6	1.3	-1.0	-0.4	2.0	2.1	-1.9	-0.2	-1.7	1.2	1.5	-0.2	-0.5
Medication: Ventolin 100micrograms inhaler	0.8	1.0	7.0	-2.6	-0.7	0.1	0.9	-1.0	-1.0	1.2	-0.5	0.4	-0.2	-0.4	0.3	0.7
Birth weight	0.7	1.6	9.8	0.1	-3.1	1.8	-0.1	-0.5	-0.3	1.2	-1.6	0.9	0.4	-1.3	-0.4	-1.0
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.7	0.9	0.4	1.3	-0.1	0.6	0.5	-0.2	-0.4	0.2	1.0	0.6	0.7	0.1
High blood pressure (siblings)	0.4	0.6	1.3	0.9	-0.3	1.1	-0.9	0.8	0.7	-0.4	1.0	1.1	-0.4	-0.6	-0.2	-0.8
Forced vital capacity (FVC), Best measure	0.2	0.6	2.4	1.0	-1.0	0.6	0.3	-0.2	-0.2	1.5	-0.1	-0.3	1.0	0.1	0.8	-1.3
Body fat percentage	0.7	2.8	7.9	0.0	-1.9	1.1	-1.9	-0.7	-0.6	-0.0	-1.1	2.6	-2.5	-2.8	-2.0	-1.0
Leg fat percentage (right)	1.3	4.6	13.5	-0.4	-2.3	1.1	-2.1	-1.6	-1.5	0.8	-1.4	3.2	-3.2	-3.7	-2.3	-1.1
Arm fat-free mass (right)	0.4	2.2	5.0	-2.2	-2.1	0.9	-0.5	-0.4	-0.3	-0.0	-2.2	1.6	-1.3	-1.9	-2.0	0.6
Exposure to tobacco smoke outside home	0.5	0.7	2.8	-1.7	-1.3	-1.1	-0.0	-0.3	-0.3	0.1	0.2	0.1	-1.0	-1.3	-0.9	0.1
Comparative body size at age 10	0.6	1.7	4.3	-0.1	-0.7	-1.3	-0.9	1.8	1.9	-1.8	-1.5	-0.6	-0.7	-0.3	-2.1	-1.1
Number of full brothers	0.7	0.8	2.4	-0.3	1.0	1.2	0.8	-0.7	-0.8	1.1	1.0	0.2	0.4	0.6	1.6	1.2
Worry too long after embarrassment	1.1	1.8	6.2	0.0	0.5	-0.4	1.2	-2.2	-2.0	2.5	0.4	-0.9	0.9	0.7	1.9	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	3.3	-1.8	-0.0	-1.8	0.2	-1.1	-0.9	0.7	0.2	-0.4	-1.1	-0.5	-0.6	-0.4
Wheeze or whistling in the chest in last year	0.7	1.2	3.2	-1.1	-1.2	-1.0	-0.6	-1.2	-1.2	0.5	-1.1	0.9	-1.8	-1.6	-0.9	-0.5
Number of children fathered	1.1	1.2	4.1	-1.0	0.5	-1.8	1.3	0.4	0.5	0.3	-1.5	-2.0	0.9	1.3	0.0	0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	6.5	-0.7	-1.4	-0.8	-0.7	1.7	1.8	-1.4	-2.5	-0.4	-0.4	-0.7	-2.5	-0.9
Age at first live birth	1.0	1.7	4.5	0.2	1.9	-1.6	1.4	0.5	0.5	-0.3	0.5	-2.1	1.4	2.1	0.3	1.4
Pulse wave peak to peak time	0.4	0.5	1.4	0.3	-0.3	-0.1	-1.0	0.3	0.2	-1.0	0.8	0.7	-1.2	-0.9	-0.2	-0.6
Health satisfaction	1.0	1.3	4.3	-1.0	-0.7	-2.1	-0.9	-0.3	-0.2	-0.3	-0.5	-0.1	-1.9	-1.3	-1.8	-1.4
Shortness of breath walking on level ground	0.3	0.4	1.7	-0.4	0.4	1.2	-0.5	-0.0	-0.1	-0.3	0.4	1.3	-0.4	-0.3	-0.1	0.9
Qualifications: College or University degree	2.0	6.4	17.7	-2.9	2.3	-1.5	4.2	0.1	0.2	1.4	-0.9	-3.4	3.4	3.7	1.3	2.8
Eye problems/disorders: None of the above	0.8	0.9	1.9	-0.3	1.4	-0.4	0.5	1.3	1.1	-1.3	1.2	-0.5	0.5	1.1	0.8	0.9
Mouth/teeth dental problems: Loose teeth	2.0	2.3	6.3	0.8	-0.8	0.0	-2.5	0.5	0.5	-1.4	0.0	1.8	-2.5	-2.1	-1.5	-2.0
Emphysema/chronic bronchitis	0.8	0.9	2.0	-0.3	-0.9	0.5	-0.9	-1.4	-1.3	1.0	-1.2	1.2	-0.9	-1.2	-0.6	-0.5
Medication for pain relief, constipation, heartburn	0.5	0.9	2.5	0.7	0.6	0.4	0.4	1.5	1.4	-0.6	-0.5	-0.9	1.6	1.4	0.8	-0.1
Neck or shoulder pain in last month	0.5	0.7	3.1	-0.4	-1.8	-0.0	-0.7	-0.6	-0.5	0.5	-0.5	0.7	-0.7	-1.4	-0.2	-1.2
Medication: Blood pressure	0.7	1.2	3.2	0.5	-0.2	-0.8	-1.7	0.2	0.3	-1.0	1.1	0.8	-1.8	-1.4	-1.3	-1.5
Angina (self-reported)	0.5	0.7	1.9	-1.3	0.2	-0.6	-0.4	-1.2	-1.1	-0.1	0.1	0.8	-1.4	-0.8	-0.9	0.4
Migraine (self-reported)	0.9	1.2	3.2	0.6	-0.3	-0.0	-1.8	0.6	0.6	-1.8	-1.2	0.8	-1.4	-1.0	-1.4	-0.6
Medication: Ibuprofen	1.1	1.4	4.2	-1.9	0.3	-1.5	2.1	-0.6	-0.6	1.3	-0.3	-1.4	0.8	0.6	0.7	1.2
Medication: Allopurinol	1.1	1.4	3.8	0.8	-1.9	-0.6	-1.3	0.6	0.8	-0.7	-1.2	0.2	-1.0	-1.4	-1.7	-1.8
Medication: Omeprazole	0.9	1.1	3.4	1.2	-1.1	0.6	-1.6	0.8	0.9	-0.8	0.6	0.7	-0.9	-1.1	-0.6	-1.8
Medication: Seretide 50 evohaler	0.4	0.4	1.2	-1.1	-0.8	1.1	-0.1	-0.5	-0.5	-0.1	-0.1	1.0	-0.2	-0.4	-0.6	0.5
Mean time to correctly identify matches	0.4	0.7	2.1	0.2	0.8	0.5	1.1	-0.0	0.1	1.1	0.4	-0.8	1.4	1.3	1.0	0.1
Heart disease (mother)	0.7	0.9	2.5	-0.7	-0.1	-1.5	-1.2	-0.0	0.1	-1.2	-0.0	0.1	-1.6	-0.9	-1.4	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	1.0	-1.0	-0.4	-0.2	0.4	0.2	0.2	-0.3	-0.6	0.0	-0.2	-0.2	-0.1	0.5
Whole body fat mass	0.7	2.8	7.5	-0.8	-2.1	1.3	-1.5	-0.7	-0.6	0.0	-1.5	2.6	-2.2	-2.7	-2.2	-0.3
Leg fat mass (right)	1.2	4.7	12.9	-1.2	-3.0	0.9	-1.8	-1.1	-1.0	0.4	-2.2	2.9	-3.0	-3.6	-2.9	-0.8
Arm predicted mass (right)	0.4	2.2	5.3	-1.9	-2.3	1.0	-0.8	-0.2	-0.1	-0.2	-2.3	1.6	-1.2	-1.9	-2.2	0.3
Pulse rate, automated reading	0.3	0.9	4.5	-1.9	0.9	-2.1	0.2	-0.5	-0.3	-0.1	-0.7	-0.6	-1.0	-0.3	-1.0	-0.0
Alcohol intake frequency.	0.4	1.0	2.4	-1.6	-0.0	0.4	-1.0	1.2	1.0	-1.1	-0.7	1.2	-1.4	-1.2	-0.8	-0.4
Comparative height size at age 10	0.1	0.5	1.4	-1.2	-0.8	0.2	0.0	0.9	0.8	-0.6	-1.1	0.3	-0.2	-0.4	-1.0	0.2
Number of full sisters	1.0	1.2	4.8	-2.2	-0.4	0.6	0.7	-1.6	-1.6	1.1	-0.5	0.8	-0.1	-0.5	0.4	1.5
Suffer from ‘nerves’	0.8	1.3	5.4	-1.0	-1.5	-0.7	0.2	-0.9	-0.7	1.8	-2.3	-0.1	-0.3	-0.9	-1.0	-1.3
Overall health rating	1.4	3.0	9.8	-0.8	-1.5	-0.9	-2.3	-1.0	-0.9	-0.7	-0.5	1.8	-3.1	-2.8	-2.2	-1.6
Chest pain or discomfort	0.2	0.3	1.3	0.1	-0.3	-0.4	-0.8	0.3	0.3	-0.7	-0.5	0.3	-0.7	-0.6	-0.2	-1.1
Had major operations	0.9	1.1	3.0	0.2	0.5	-1.1	1.6	-0.8	-0.6	0.9	0.8	-1.7	1.3	1.3	1.0	0.7
Age at last live birth	0.7	1.1	4.5	1.0	1.3	-1.1	-0.9	0.8	0.8	-2.1	1.6	-0.2	-0.6	0.4	-0.5	0.5
Family relationship satisfaction	0.5	0.6	2.0	0.3	1.1	-1.0	0.5	-0.5	-0.3	0.5	-0.7	-1.4	0.7	1.1	0.6	-0.2
Leg pain on walking	0.2	0.3	1.0	-0.9	-0.1	-1.0	-0.1	-0.3	-0.2	-0.7	0.3	-0.3	-0.5	-0.3	-0.7	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	3.2	0.3	0.0	-0.5	-1.2	1.1	1.0	-1.8	-0.7	0.3	-1.0	-0.5	-1.3	-0.5
Commuting to job workplace: Car/motor vehicle	2.3	2.6	5.0	-1.9	-2.2	-1.1	-0.1	-1.6	-1.4	1.7	-2.2	0.5	-1.5	-2.0	-1.9	-1.3
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	4.4	0.7	1.9	0.7	0.2	0.4	0.1	-0.2	2.1	0.2	0.4	0.9	1.6	0.5
Medication: Aspirin	0.4	0.5	2.5	0.7	1.5	-0.4	0.0	-0.3	-0.2	-0.5	1.6	-0.2	-0.4	0.3	0.0	0.4
Supplements: Vitamin C	1.0	1.2	5.1	0.0	0.5	1.6	0.9	-0.8	-0.9	1.4	1.3	0.6	0.7	0.4	2.2	0.9
Knee pain experienced in last month	1.5	2.4	7.4	-0.2	-2.7	0.8	-1.7	0.6	0.5	-0.8	-1.3	1.8	-1.6	-2.3	-1.8	-1.6
Hypertension (Self-reported)	0.8	2.2	7.1	1.5	0.0	0.6	-2.3	0.1	0.1	-0.8	2.7	1.7	-2.0	-1.7	-0.6	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.7	0.6	-0.7	0.6	-0.8	0.5	0.5	-0.1	0.4	0.6	-0.6	-0.8	-0.2	-1.3
Illnesses of father: Heart disease	0.5	0.7	2.6	0.3	-1.2	-1.1	0.5	0.1	0.3	0.4	-1.6	-1.1	0.4	0.0	-0.7	-0.9
Illnesses of siblings: Diabetes	2.3	2.9	8.0	0.7	-0.9	0.9	-2.0	2.8	2.8	-2.8	-1.0	0.7	-0.6	-0.9	-2.0	-1.2
Smoking status: Previous	0.4	0.5	1.6	0.2	-1.1	-1.3	0.3	0.3	0.5	-0.1	-1.1	-0.9	0.0	-0.1	-1.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	6.6	-1.2	-1.4	0.0	0.3	0.5	0.4	0.2	-2.6	0.1	0.2	-0.5	-0.8	0.3
Whole body fat-free mass	0.3	1.5	5.2	-2.0	-1.7	0.2	-0.0	0.2	0.2	-0.3	-2.3	0.6	-0.6	-1.1	-2.0	0.7
Leg fat-free mass (right)	0.3	1.4	4.3	-2.1	-1.6	0.3	-0.1	0.5	0.5	-0.7	-2.0	0.7	-0.5	-0.9	-2.0	0.8
Arm fat percentage (left)	0.6	2.2	5.8	0.2	-1.7	0.7	-1.9	-0.0	0.1	-0.7	-0.7	2.1	-2.2	-2.4	-2.1	-1.1
Average weekly red wine intake	0.4	0.6	2.4	0.2	-0.5	-0.3	-0.6	0.4	0.5	-0.4	-1.5	-0.1	-0.4	-0.6	-1.3	-1.2
Handedness (chirality/laterality): Left-handed	1.1	1.3	3.1	-0.6	1.0	-1.0	1.8	-0.5	-0.4	0.9	1.3	-1.5	1.0	1.5	1.0	1.4
Mood swings	2.4	4.4	11.3	-2.3	-2.4	0.4	-2.0	-1.8	-1.8	0.5	-1.8	2.8	-3.1	-3.4	-1.5	-1.1
Loneliness, isolation	1.2	1.7	5.2	-1.4	-0.7	1.0	-0.5	-2.3	-2.2	1.2	0.8	1.6	-1.1	-1.3	0.4	0.6
Long-standing illness, disability or infirmity	0.5	0.7	1.8	-1.3	-0.1	0.7	0.1	-1.2	-1.2	0.8	0.6	1.2	-0.7	-0.8	-0.1	0.6
Ever had bowel cancer screening	0.7	0.8	2.0	0.8	1.2	0.1	0.7	0.9	0.9	-0.2	-0.6	-1.1	1.4	1.4	0.5	0.3
Diabetes diagnosed by doctor	0.9	1.5	4.3	-0.1	0.3	-1.9	-0.5	1.3	1.5	-2.0	-1.2	-1.0	-0.6	-0.1	-2.1	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	4.0	-1.8	-0.3	-0.5	0.8	-1.8	-1.9	1.5	2.0	0.8	-1.1	-1.0	0.5	1.4
Friendships satisfaction	0.3	0.3	1.0	0.7	0.9	0.7	-0.3	-0.6	-0.6	0.4	0.7	0.3	0.1	0.3	1.0	-0.3
Qualifications: nursing, teaching	1.8	2.8	6.9	-2.6	1.1	-2.6	2.6	-0.3	-0.3	0.9	-1.4	-2.6	1.2	1.6	0.0	1.1
Commuting to job workplace: Walk	1.9	2.0	8.3	0.8	0.4	-0.6	-0.4	2.9	2.7	-2.7	-0.5	-0.9	0.6	0.7	-0.5	-0.2
Eye problems/disorders: Cataract	0.2	0.3	1.4	0.6	-0.5	0.7	0.3	-0.4	-0.4	1.2	-0.2	0.0	0.5	-0.1	0.2	0.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.7	-0.6	-0.8	1.6	0.0	-0.7	-0.8	1.1	0.1	1.2	0.0	-0.6	0.9	0.1
Medication for cholesterol	1.2	1.8	5.2	-2.1	-0.4	0.6	1.8	-0.7	-0.9	1.6	-2.3	-0.0	0.9	0.3	0.1	2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.3	0.1	-0.3	1.0	-0.6	-0.7	-0.7	0.3	0.9	1.1	-0.5	-0.8	0.2	-0.0
Back pain experienced in last month	0.1	0.1	0.9	-0.1	-0.2	-0.1	0.1	-0.4	-0.4	0.5	-1.0	0.1	-0.1	-0.3	-0.3	-0.0
Mineral and other dietary supplements	0.3	0.4	1.1	-1.1	0.3	0.3	-0.4	-0.0	-0.2	-0.1	-0.8	0.9	-0.9	-0.8	-0.6	0.3
Breast cancer (self-reported)	1.2	1.5	3.4	1.3	1.8	-0.4	-0.7	1.8	1.9	-1.8	1.1	-0.8	0.4	1.2	-0.5	-0.5
Asthma (self-reported)	1.4	2.8	5.8	-2.3	-1.8	-1.7	-0.5	-2.1	-1.8	1.1	-2.4	0.4	-1.9	-1.8	-1.7	-1.1
Osteoporosis (self-reported)	0.3	0.4	1.6	0.1	-0.9	1.2	-0.3	0.8	0.8	-0.1	-0.5	0.6	0.3	-0.5	-0.4	-0.6
Osteoarthritis (self-reported)	0.9	1.2	3.7	-1.9	1.0	-0.5	1.4	-1.1	-1.2	1.0	0.9	-0.5	0.3	0.5	1.0	1.5
Medication: Aspirin	0.4	0.5	2.2	0.2	1.5	-0.1	0.6	-0.6	-0.6	-0.0	1.4	-0.3	-0.0	0.5	0.4	0.9
Medication: Gliclazide	0.3	0.4	2.2	-0.4	0.3	1.5	-0.1	0.2	0.2	-0.2	-0.8	0.9	0.1	-0.2	-0.3	0.9
Illnesses of father: None of the above (group 1)	1.2	1.5	4.8	-0.1	0.5	2.2	0.3	-0.9	-1.0	0.9	2.2	1.3	0.5	0.1	2.0	1.2
Smoking status: Current	0.8	1.2	4.1	0.3	-0.8	0.3	-0.1	-1.9	-1.8	2.0	-0.0	1.1	-0.7	-1.1	0.6	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.1	0.8	-0.4	0.4	-1.0	0.6	0.6	-0.4	0.7	0.5	-0.3	-0.6	-0.3	-1.0
Whole body water mass	0.2	1.4	5.2	-2.0	-1.7	0.2	0.0	0.3	0.4	-0.4	-2.3	0.5	-0.5	-0.9	-2.0	0.6
Leg predicted mass (right)	0.2	1.3	4.2	-2.1	-1.6	0.4	-0.0	0.5	0.5	-0.6	-1.9	0.7	-0.5	-0.9	-1.8	0.9
Arm fat mass (left)	0.6	2.5	6.4	-0.6	-2.2	1.1	-1.7	-0.3	-0.2	-0.4	-1.2	2.3	-2.1	-2.5	-2.2	-0.6
Number of self-reported non-cancer illnesses	1.1	1.9	4.7	-1.2	-0.2	-1.4	-1.6	-0.7	-0.5	-0.3	-1.8	0.6	-2.2	-1.5	-2.0	-1.9
Average weekly champagne plus white wine intake	0.5	0.7	4.5	-0.7	-2.1	0.1	0.1	-0.6	-0.6	0.9	-0.4	0.5	-0.4	-1.1	-0.9	-0.3
Miserableness	1.0	1.8	5.4	-2.2	-1.0	-0.6	-0.6	-1.5	-1.4	0.5	-2.3	0.9	-1.6	-1.4	-1.3	-0.3
Guilty feelings	2.3	3.5	12.4	-2.0	-1.0	0.4	1.4	-3.3	-3.2	3.5	-0.5	0.5	0.2	-0.6	1.6	0.8
Wears glasses or contact lenses	1.0	1.2	3.5	-1.9	0.4	0.7	0.3	-1.6	-1.6	1.4	-0.9	1.2	-0.8	-0.5	0.1	1.1
Ever taken oral contraceptive pill	0.3	0.3	0.9	0.4	-0.4	-0.8	-0.6	0.1	0.2	-0.8	-0.1	-0.3	-0.6	-0.3	-0.9	-0.7
Hearing aid user	0.5	0.6	4.2	2.0	-0.7	0.5	-0.6	0.5	0.6	-0.1	-0.2	-0.0	0.2	-0.2	-0.0	-1.2
Mother’s age at death	0.5	0.6	3.4	0.8	0.4	1.8	-0.1	0.6	0.6	0.3	-0.5	0.2	1.3	0.9	0.5	-0.3
Financial situation satisfaction	0.9	1.1	5.3	1.6	-0.1	-1.4	-1.6	0.1	0.2	-0.7	0.7	-0.3	-0.9	-0.2	-0.1	-2.3
Tinnitus: Yes, now most or all of the time	1.0	1.2	3.8	0.5	-1.5	1.4	-1.2	0.3	0.1	-0.4	0.3	1.9	-1.4	-1.8	-0.6	-0.5
Commuting to job workplace: Public transport	0.4	0.5	1.6	0.1	0.7	0.5	0.8	0.4	0.3	0.1	-0.4	-0.5	1.2	1.2	0.7	1.1
Eye problems/disorders: Glaucoma	0.4	0.5	1.2	-0.5	0.7	-0.5	0.7	-1.0	-0.9	0.9	-1.1	-0.5	0.4	0.7	0.1	0.5
Medication: Blood pressure	1.1	2.2	5.9	2.4	0.4	0.5	-2.2	1.4	1.5	-2.0	1.9	0.6	-0.8	-0.5	-0.6	-1.9
Pain type(s) experienced in last month: Hip pain	0.7	0.8	5.2	-0.8	-0.9	-2.3	-0.0	-0.1	0.0	-0.1	0.1	-1.0	-0.8	-0.6	-1.4	-0.5
Supplements: Fish oil (including cod liver oil)	0.4	0.5	2.3	1.0	-0.2	-0.0	0.0	-0.5	-0.5	0.3	1.5	-0.3	0.3	0.4	1.3	-0.3
High cholesterol (Self-reported)	2.4	4.2	16.3	1.0	3.3	-4.0	0.8	0.9	1.1	-1.3	0.1	-3.6	0.9	2.6	0.7	-0.9
Medication: Bendroflumethiazide	1.4	2.1	10.6	0.8	0.0	0.0	-2.1	0.1	0.1	-1.6	3.2	1.3	-2.0	-1.2	-0.5	-1.0
Medication: Paracetamol	2.4	3.7	8.5	-1.8	-1.7	1.0	-0.7	-2.9	-2.9	1.6	1.0	2.6	-2.4	-2.7	-0.4	0.1
Medication: Lisinopril	2.8	3.7	10.9	0.7	-0.9	2.9	-2.9	1.4	1.1	-2.3	1.6	3.3	-1.7	-2.0	-0.4	-0.8
Medication: Atorvastatin	0.6	0.7	3.1	0.0	0.3	-1.8	0.0	-1.4	-1.3	0.6	0.3	-0.5	-1.0	-0.6	0.0	-0.7
Illnesses of father: High blood pressure	0.4	0.5	3.8	0.3	2.0	-1.2	-0.0	-0.1	-0.1	-0.2	0.9	-0.5	-0.6	0.3	-0.2	0.2
Alcohol drinker status: Never	0.8	1.0	4.1	-2.0	0.6	0.6	-0.1	-0.8	-1.0	0.1	0.4	1.1	-1.2	-0.9	-0.1	1.6
Ever smoked	0.7	1.3	6.6	0.0	-2.6	0.4	-0.1	-1.1	-1.0	1.4	-0.8	1.0	-0.7	-1.6	-0.7	-0.7
Basal metabolic rate	0.3	1.8	5.5	-1.9	-2.1	0.3	-0.4	0.1	0.2	-0.3	-2.3	0.9	-0.9	-1.5	-2.2	0.3
Leg fat percentage (left)	1.6	5.8	17.0	-0.6	-2.7	1.4	-2.3	-2.0	-1.9	0.9	-1.0	3.8	-3.6	-4.1	-2.3	-1.0
Arm fat-free mass (left)	0.4	2.2	5.1	-2.0	-2.3	0.6	-0.5	-0.6	-0.5	0.2	-2.3	1.5	-1.4	-1.9	-2.1	0.5
Number of operations (self-reported)	0.9	1.3	3.3	-0.6	1.1	-0.7	1.8	-0.5	-0.5	1.1	1.4	-1.5	1.3	1.5	1.0	1.1
Average weekly beer plus cider intake	0.0	0.0	0.3	0.5	-0.4	-0.1	-0.0	-0.0	-0.1	0.0	-0.1	0.0	0.0	-0.1	0.1	-0.1
Irritability	1.4	2.4	8.1	-2.9	-0.7	-0.8	-0.5	-1.6	-1.6	0.2	-1.1	1.4	-2.3	-2.0	-1.8	0.6
Risk taking	2.2	3.2	8.7	-2.8	0.3	0.1	2.0	-2.9	-2.9	2.8	0.5	0.4	-0.2	-0.4	0.9	2.0
Ever had prostate specific antigen (PSA) test	1.9	2.2	9.1	3.0	-0.4	-0.7	-0.4	1.6	1.8	-0.4	-2.2	-1.6	1.4	0.9	-0.4	-1.9
Fractured/broken bones in last 5 years	1.3	1.7	3.8	-0.9	2.0	-0.0	1.7	0.1	0.0	0.5	-0.9	-1.2	1.7	1.9	1.3	1.9
Age started oral contraceptive pill	1.2	1.4	5.2	-0.3	1.7	1.4	0.2	-0.9	-1.1	0.6	2.3	0.8	0.3	0.5	1.7	1.4
Diastolic blood pressure, automated reading	0.3	0.8	2.2	1.3	1.0	0.1	-1.3	1.1	1.0	-1.5	0.1	0.4	-0.7	-0.1	-0.5	-0.9
Ever depressed for a whole week	0.5	0.6	1.8	-0.8	1.4	-0.0	0.9	-0.1	-0.1	0.1	-0.1	-0.6	0.8	1.1	0.4	1.3
Unable to work because of sickness or disability	1.4	1.8	4.7	-0.8	-1.1	0.7	-1.1	-1.6	-1.4	1.0	0.4	2.0	-2.0	-2.2	-0.7	-0.8
Commuting to job workplace: Cycle	0.3	0.4	1.1	0.3	0.0	1.1	0.4	0.9	0.8	-0.2	-0.0	0.1	0.8	0.6	0.8	0.5
Myopia	0.3	0.5	1.4	0.9	-0.5	1.1	-0.5	0.7	0.6	-0.2	1.2	0.7	-0.2	-0.3	0.0	-0.6
Vascular/heart problems diagnosed by doctor	1.1	3.1	9.4	-0.9	0.6	0.1	2.7	0.5	0.4	0.8	-2.1	-2.1	3.1	2.6	1.5	2.0
Cholesterol lowering medication	1.0	1.5	5.2	2.3	1.0	-0.8	-0.6	0.6	0.7	-1.3	1.8	-1.2	0.5	0.9	1.2	-1.5
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	2.0	0.7	-0.4	0.1	-1.4	0.6	0.6	-0.9	0.5	0.6	-1.1	-0.9	-0.4	-1.4
Pain experienced in last month	1.3	2.2	4.8	0.2	2.0	-0.1	1.5	0.8	0.7	-0.2	1.7	-1.7	2.0	2.2	2.0	1.4
Supplements: Calcium	0.7	0.8	2.7	0.4	0.8	-0.8	0.8	0.8	0.8	-0.1	-0.5	-1.6	1.4	1.5	0.4	-0.2
Basal cell carcinoma (self-reported)	0.8	1.0	2.8	-1.3	1.7	-0.5	1.1	-0.8	-0.9	0.4	0.5	-0.5	0.3	0.8	1.1	1.6
Heart attack/myocardial infarction (self-reported)	1.4	1.9	5.8	0.6	-2.4	0.3	-1.8	0.7	0.7	-0.9	-0.0	1.1	-1.3	-2.2	-1.2	-2.0
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.6	-1.0	-0.9	-0.2	-0.6	0.1	0.1	-0.4	-1.6	0.7	-1.2	-1.0	-1.4	-0.5
Heart disease (siblings)	0.4	0.4	2.1	0.3	0.4	0.8	0.3	-0.6	-0.7	0.5	1.4	0.6	-0.1	-0.3	0.5	0.9
Alcohol drinker status: Previous	0.8	0.9	2.8	0.0	-1.2	1.3	-1.1	0.4	0.4	-0.4	-0.8	1.7	-0.9	-1.3	-0.9	-0.6
Pack years of smoking	0.5	0.7	2.0	-0.7	1.1	0.2	-0.6	-1.0	-1.1	0.3	0.3	1.2	-1.4	-0.8	0.2	-0.1
Impedance of whole body	0.3	1.8	10.9	3.3	0.9	1.2	-0.4	0.4	0.3	0.4	1.6	0.2	1.0	0.7	2.0	-1.1
Leg fat mass (left)	1.3	5.1	14.5	-1.3	-3.0	1.1	-1.9	-1.3	-1.2	0.5	-1.9	3.2	-3.2	-3.8	-2.8	-0.7
Arm predicted mass (left)	0.4	2.0	5.8	-2.1	-2.1	0.4	-0.3	-0.4	-0.4	0.2	-2.4	1.1	-1.2	-1.7	-2.1	0.5