Hub : Genes

HTR5BP

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Heart Atrial Appendage 0.220 0.071 3.9e-04 0.087 NA 0.071 NA 0.081 1.0e-04 NA 4.0e-04 NA 1.6e-04
2 GTEx Testis 0.549 0.079 1.1e-09 0.139 NA 0.232 NA 0.203 9.4e-07 NA 1.2e-10 NA 2.1e-09

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.4 0.6 1.2 -1.1 0.3
Bipolar Disorder or Schizophrenia 0.0 0.0 0.0 -0.2 -0.0
Depressed Affect (Nagel 2018) 1.3 2.6 5.3 -2.3 -0.0
Depression (Nagel 2018) 4.5 6.8 13.3 -3.7 0.4
Intelligence (Savage-Jansen 2018) 0.6 1.8 3.0 -0.7 1.7
Neuroticism (Nagel 2018) 2.2 5.2 8.6 -2.9 1.3
Schizophrenia (2018) 0.1 0.2 0.4 0.6 -0.3
Schizophrenia vs Biploar Disorder 1.8 2.3 3.7 1.9 -1.0
Worry (Nagel 2018) 0.9 1.8 2.0 -1.4 1.3
Alzheimer’s Disease (in mother) 1.4 1.6 3.0 -1.7 0.5
Alzheimer’s Disease (in father) 3.5 3.8 5.2 -2.3 1.5
Alzheimer’s Disease (including proxy) 2.0 2.9 4.5 -2.1 1.2
Crohns Disease (2017) 0.1 0.2 0.3 -0.5 0.3
Irritable Bowel Disease (IBD) 0.6 1.4 2.3 -1.5 0.7
Ulcerative Colitis (UC) 1.2 2.3 3.0 -1.7 1.3
Major Depression (MDD) 2.3 2.8 5.6 -2.4 -0.1
Reaction Time 0.2 0.3 0.3 -0.6 0.6
Verbal and Numeric Reasoning (VNR) 1.2 2.8 4.2 -1.2 2.0
Breast Cancer 1.7 4.0 5.2 -1.7 2.3
Ovarian Cancer 0.5 0.6 0.9 0.6 -0.9
Prostate Cancer 0.6 0.8 1.3 -1.1 0.6
Age at First Birth 2.5 3.6 5.6 2.4 -1.3
Bipolar Disorder (2011) 0.7 0.7 1.4 -0.1 -1.2
Body Mass Index (BMI) (2010) 1.4 2.0 3.4 -1.9 -0.7
Coronary Artery Disease (CAD) 1.4 1.7 2.5 -0.9 1.6
Crohns Disease (2012) 0.1 0.2 0.3 0.1 0.6
Mean Putamen Volume 0.8 0.9 1.8 -0.0 -1.4
Fasting Glucose 1.6 1.9 3.8 -0.3 1.9
HbA1C 0.2 0.3 0.3 0.4 0.6
HDL Cholesterol 2.0 3.4 6.4 0.7 -2.5
LDL Cholesterol 5.2 8.2 16.5 0.1 4.1
Lupus 0.5 0.7 1.1 0.5 -1.0
Neuroticism (2016) 0.2 0.3 0.6 -0.8 -0.2
Primary Biliary Cirrhosis 0.8 1.2 1.9 -1.4 -0.7
Rheumatoid Arthritis 1.1 1.5 2.5 -1.6 0.7
Schizophrenia (2014) 0.4 0.8 1.3 0.6 -1.1
Triglycerides 0.9 1.4 2.9 -0.0 1.7
Type 2 Diabetes (T2D) (2012) 1.3 1.5 3.0 1.7 -0.2
Ulcerative Colitis 0.7 1.1 2.1 -1.4 0.2
Blood Eosinophil Count 0.1 0.7 1.3 -1.1 0.2
Blood Platelet Count 0.1 0.9 1.8 1.4 0.1
Blood Red Count 0.0 0.0 0.1 -0.2 0.1
Blood White Count 0.4 3.2 4.7 -2.2 1.3
Heel T-Score 2.4 19.0 32.5 -5.7 -2.3
BMI 0.6 3.5 3.7 -1.8 -1.9
Height 0.1 1.3 2.3 -0.5 -1.5
Waist Hip Ratio (WHR) 0.8 3.8 7.5 2.7 -0.1
Systolic Blood Pressure 0.6 2.9 3.9 1.4 -2.0
Smoking Status 3.4 8.1 13.0 -3.6 1.8
Allergy or Eczema 0.5 1.3 1.4 -1.2 1.1
Cardiovascular Disease 0.4 1.4 2.7 0.2 1.6
Hypothyroidism (self reported) 0.8 1.8 3.6 -1.9 -0.0
Respiratory disease 2.3 5.1 10.2 -3.2 0.3
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.3 -0.2 -0.5
Lung FEV1/FVC ratio 0.2 1.0 1.9 -0.3 1.4
Lung FVC 0.1 0.5 1.0 0.3 1.0
Neuroticism 2.7 6.4 9.4 -3.1 1.9
Chronotype (morning person) 0.0 0.1 0.2 0.1 0.4
Hair Pigment 0.3 9.4 18.1 -0.8 4.3
Tanning 0.4 4.6 4.8 2.1 -2.2
Hand grip strength (left) 0.4 1.0 1.6 -1.2 -0.6
Number of treatments/medications taken 0.5 0.8 1.6 -1.3 0.1
Average weekly spirits intake 0.0 0.0 0.0 0.1 0.0
Sensitivity / hurt feelings 0.3 0.6 0.7 -0.9 0.7
Frequency of depressed mood in last 2 weeks 4.4 6.1 11.7 -3.4 0.7
Hearing difficulty/problems: Yes 0.1 0.1 0.2 -0.1 0.4
Relative age of first facial hair 0.1 0.2 0.4 -0.6 -0.0
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 1.6 -1.0 1.3
Ever used hormone-replacement therapy (HRT) 0.2 0.3 0.5 -0.7 -0.4
Ever had hysterectomy (womb removed) 0.3 0.3 0.6 -0.0 0.8
Systolic blood pressure, automated reading 1.1 3.3 3.7 1.7 -1.9
Eye problems/disorders: Diabetes related eye disease 1.6 1.7 3.3 0.4 -1.8
Angina 0.3 0.4 0.7 -0.8 -0.2
Medication for hormone replacement therapy 1.1 1.2 1.6 -1.3 0.9
Vitamin and mineral supplements 1.0 1.3 2.1 0.7 -1.4
Supplements: Zinc 0.0 0.0 0.0 -0.1 0.1
Medication: Co-codamol 0.2 0.3 0.5 0.7 -0.2
Medication: Metformin 0.7 1.0 2.1 1.4 -0.1
Diabetes (father) 4.4 5.4 9.8 3.1 -1.0
Diabetes (mother) 1.5 1.9 3.5 1.9 -0.4
Severe depression (siblings) 0.8 0.9 1.8 1.3 -0.3
Pack years adult smoking proportion 0.1 0.2 0.2 -0.5 0.4
Impedance of leg (right) 0.4 2.0 3.1 -1.8 0.9
Leg fat-free mass (left) 0.3 1.8 3.3 0.5 -1.8
Trunk fat percentage 0.8 3.2 5.7 -0.9 -2.4
Hand grip strength (right) 0.2 0.6 1.2 0.1 -1.1
Townsend deprivation index at recruitment 0.2 0.3 0.6 -0.3 -0.8
Current tobacco smoking 1.1 1.7 2.3 -1.5 1.1
Average weekly fortified wine intake 0.0 0.0 0.1 -0.1 -0.3
Maternal smoking around birth 0.3 0.4 0.9 0.1 0.9
Fed-up feelings 0.6 1.0 1.5 -1.2 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 8.4 11.2 20.6 -4.5 1.3
Relative age voice broke 0.1 0.1 0.1 0.1 0.4
Taking other prescription medications 0.3 0.4 0.7 -0.3 -0.8
Age when periods started (menarche) 0.4 0.9 1.9 -1.4 0.1
Bilateral oophorectomy (both ovaries removed) 0.1 0.2 0.3 -0.2 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 2.2 4.9 5.8 -2.4 -2.0
Tinnitus: Yes, but not now, but have in the past 1.2 1.2 2.4 0.2 -1.6
Qualifications: CSEs or equivalent 0.2 0.2 0.4 -0.2 0.6
Serious illness, injury or assault to yourself 0.7 0.9 1.2 -0.8 1.1
High blood pressure 0.4 1.0 1.5 1.2 -0.8
Hayfever, allergic rhinitis or eczema 0.5 1.0 1.2 -0.9 1.1
Multivitamins +/- minerals 0.7 0.9 1.9 -0.1 1.4
Stomach or abdominal pain in last month 0.3 0.4 0.8 -0.9 -0.2
Supplements: Glucosamine 0.2 0.2 0.4 -0.6 0.3
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 0.5 -0.7 -0.2
Medication: Atenolol 1.3 1.6 3.0 0.4 -1.7
Medication: Levothyroxine sodium 0.4 0.7 0.9 -1.0 -0.6
Sitting height 0.1 1.1 2.1 -1.4 0.0
Chronic bronchitis/emphysema (father) 2.3 2.7 5.2 0.4 -2.3
High blood pressure (mother) 1.6 2.3 4.3 2.1 -0.5
Body mass index (BMI) 0.7 3.0 4.7 -1.1 -2.2
Impedance of leg (left) 0.6 2.8 4.5 -2.1 1.1
Leg predicted mass (left) 0.4 2.0 3.5 0.6 -1.9
Trunk fat mass 0.9 3.8 6.7 -0.9 -2.6
Waist circumference 0.5 1.9 3.7 -0.2 -1.9
Number of incorrect matches in round 0.5 0.8 1.5 -0.2 -1.2
Past tobacco smoking 0.3 0.6 1.1 1.1 -0.0
Alcohol usually taken with meals 0.1 0.1 0.1 0.2 0.4
Nervous feelings 0.2 0.3 0.5 -0.4 0.7
Frequency of tenseness / restlessness in last 2 weeks 2.7 4.2 8.3 -2.9 0.2
Hearing difficulty/problems with background noise 0.1 0.1 0.1 0.3 0.3
Hair/balding pattern: Pattern 2 1.4 1.8 2.9 -0.8 1.7
Had menopause 0.3 0.4 0.7 0.1 -0.9
Had other major operations 1.0 1.3 1.8 -0.8 1.3
Forced vital capacity (FVC) 0.1 0.4 0.8 0.0 0.9
Heel bone mineral density (BMD) T-score, automated (right) 2.5 5.8 8.0 -1.9 -2.8
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 0.9 -0.9 0.5
Qualifications: None of the above 1.6 3.4 5.0 1.3 -2.2
Financial difficulties in last 2 years 0.1 0.2 0.3 0.6 0.1
Mouth/teeth dental problems 0.0 0.1 0.1 0.3 0.1
Heart attack 0.0 0.1 0.1 0.2 -0.2
Allergy 1.8 4.1 5.6 2.4 -1.6
Pain all over the body in last month 0.5 0.5 0.7 -0.9 -0.6
Diabetes (self-reported) 0.6 0.9 1.4 1.2 -0.7
Hayfever/allergic rhinitis (self-reported) 0.8 1.0 2.0 -1.4 -0.3
Medication: Ramipril 0.2 0.3 0.6 0.0 -0.8
Medication: Simvastatin 1.9 2.7 5.4 2.3 0.3
Fluid intelligence score 1.4 2.9 4.6 -1.1 2.1
Illnesses of siblings 0.3 0.4 0.7 -0.4 0.8
Neuroticism score 1.9 4.0 6.0 -2.5 1.4
Weight 0.7 3.3 5.6 -1.0 -2.4
Impedance of arm (right) 0.3 1.5 1.5 1.2 1.2
Arm fat percentage (right) 0.6 2.2 4.3 -0.3 -2.1
Trunk fat-free mass 0.3 1.4 2.9 0.1 -1.7
Hip circumference 1.0 4.4 5.1 -1.9 -2.3
Time employed in main current job 3.2 3.7 4.8 1.6 -2.2
Alcohol intake versus 10 years previously 0.6 1.0 1.9 1.4 -0.2
Father’s age at death 0.7 0.9 1.7 0.4 1.3
Worrier / anxious feelings 0.1 0.3 0.4 -0.2 0.7
Frequency of tiredness / lethargy in last 2 weeks 2.5 4.0 7.8 -2.8 -0.4
Falls in the last year 1.5 2.0 3.7 -1.9 -0.6
Hair/balding pattern: Pattern 3 0.3 0.5 0.8 0.9 -0.4
Number of live births 1.9 2.7 4.6 -2.1 0.9
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 0.7 -0.3 0.8
Pulse rate 0.1 0.1 0.2 0.2 0.4
Happiness 0.3 0.3 0.7 -0.0 0.8
Noisy workplace 0.9 1.1 2.0 1.4 -0.4
Qualifications: A levels/AS levels or equivalent 0.2 0.4 0.5 0.6 0.7
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.2 1.3 -1.1 1.1
Mouth/teeth dental problems: Dentures 0.5 0.8 1.2 -0.5 -1.1
Asthma 1.9 3.8 7.0 -2.6 0.8
Medication: Ibuprofen (e.g. Nurofen) 3.4 4.3 7.9 -0.8 2.8
Medication: Cholesterol lowering 0.9 1.4 2.6 1.6 0.5
Depression (self-reported) 1.9 2.3 4.6 -2.1 0.1
Medication: Lansoprazole 2.3 2.6 4.5 -2.1 0.8
Prospective memory result 0.9 1.1 1.3 -1.1 1.0
Lung cancer (father) 0.6 0.6 1.2 -1.1 0.3
Illnesses of mother 1.1 1.4 2.3 -1.5 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 1.2 -0.3 1.1
Pulse wave Arterial Stiffness index 0.1 0.1 0.1 0.3 -0.3
Impedance of arm (left) 0.2 1.0 1.7 1.3 0.6
Arm fat mass (right) 0.9 3.5 6.7 -0.6 -2.6
Trunk predicted mass 0.3 1.6 3.1 0.1 -1.8
Standing height 0.0 0.3 0.7 0.0 -0.8
Length of working week for main job 0.5 0.5 0.9 1.0 0.3
Exposure to tobacco smoke at home 1.7 1.9 2.5 -1.2 1.6
Breastfed as a baby 0.1 0.1 0.1 -0.4 0.1
Tense / ‘highly strung’ 2.5 4.1 8.2 -2.9 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 2.1 3.2 4.1 -2.0 1.5
Hair/balding pattern: Pattern 4 0.9 2.2 3.8 0.8 -2.0
Birth weight of first child 0.1 0.1 0.2 0.1 -0.5
Peak expiratory flow (PEF) 0.2 0.5 0.6 -0.7 0.8
Pulse wave reflection index 1.1 1.4 2.3 -1.5 0.7
Ever highly irritable/argumentative for 2 days 1.3 1.5 2.5 -1.6 0.7
Loud music exposure frequency 2.5 2.8 5.5 -0.2 -2.3
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 3.0 -0.3 1.7
Mouth/teeth dental problems: Bleeding gums 0.6 0.7 1.0 0.6 -1.0
Blood clot in the leg (DVT) 0.2 0.3 0.6 -0.1 -0.8
Medication: Paracetamol 1.6 2.6 4.9 -2.2 0.5
Headache pain in last month 0.0 0.1 0.2 0.1 -0.4
Medication for cholesterol, blood pressure or diabetes 1.4 2.4 4.1 -2.0 0.8
Glaucoma (self-reported) 1.3 1.5 3.1 -1.8 0.0
Gout (self-reported) 1.2 1.6 2.4 1.5 0.9
Hypothyroidism/myxoedema (self-reported) 0.9 1.7 3.2 -1.8 0.4
Medication: Amlodipine 2.5 3.5 6.8 2.6 -0.4
Medication: Ventolin 100micrograms inhaler 1.3 1.7 2.0 -1.4 1.2
Birth weight 0.4 0.8 1.6 -1.3 -0.2
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.0 -0.0 -1.0
High blood pressure (siblings) 0.7 1.0 1.6 0.6 -1.3
Forced vital capacity (FVC), Best measure 0.3 1.1 1.9 -0.4 1.4
Body fat percentage 0.9 3.4 4.8 -1.4 -2.2
Leg fat percentage (right) 1.7 6.2 7.1 -2.7 -2.3
Arm fat-free mass (right) 0.3 1.8 3.2 -0.6 -1.8
Exposure to tobacco smoke outside home 0.9 1.2 1.4 -0.9 1.2
Comparative body size at age 10 0.8 2.3 2.3 1.5 -1.5
Number of full brothers 0.7 0.9 1.8 -1.3 0.1
Worry too long after embarrassment 3.2 5.4 6.2 -2.2 2.5
Seen a psychiatrist for nerves, anxiety, tension or depression 2.4 3.2 5.3 -1.0 2.3
Wheeze or whistling in the chest in last year 0.5 1.0 1.9 -1.4 0.2
Number of children fathered 0.9 1.0 1.9 0.3 1.4
Reason for reducing amount of alcohol drunk: Health precaution 2.7 3.2 4.8 1.3 -2.2
Age at first live birth 0.4 0.8 1.5 1.2 0.2
Pulse wave peak to peak time 0.1 0.1 0.1 -0.3 0.3
Health satisfaction 0.2 0.3 0.3 -0.5 0.6
Shortness of breath walking on level ground 0.9 1.1 2.1 0.4 -1.4
Qualifications: College or University degree 0.2 0.7 1.5 0.1 1.2
Eye problems/disorders: None of the above 1.4 1.6 3.0 1.7 0.5
Mouth/teeth dental problems: Loose teeth 0.3 0.3 0.6 0.8 -0.2
Emphysema/chronic bronchitis 2.1 2.4 4.8 -2.2 -0.2
Medication for pain relief, constipation, heartburn 0.9 1.6 2.8 1.7 -0.6
Neck or shoulder pain in last month 0.9 1.3 1.6 -1.0 1.3
Medication: Blood pressure 0.2 0.4 0.6 0.8 -0.5
Angina (self-reported) 0.2 0.3 0.5 -0.7 -0.2
Migraine (self-reported) 1.9 2.3 4.7 0.1 -2.2
Medication: Ibuprofen 3.4 4.0 7.3 -0.9 2.7
Medication: Allopurinol 0.4 0.6 1.1 1.1 0.1
Medication: Omeprazole 0.2 0.2 0.4 0.6 0.3
Medication: Seretide 50 evohaler 1.0 1.2 2.0 -0.6 -1.4
Mean time to correctly identify matches 0.1 0.2 0.2 -0.3 -0.5
Heart disease (mother) 0.2 0.2 0.3 0.6 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.3 0.4 0.5
Whole body fat mass 1.0 4.0 6.4 -1.3 -2.5
Leg fat mass (right) 1.3 5.0 6.0 -2.0 -2.5
Arm predicted mass (right) 0.4 2.0 3.8 -0.5 -1.9
Pulse rate, automated reading 0.1 0.5 0.9 -0.2 0.9
Alcohol intake frequency. 0.2 0.4 0.9 0.9 -0.0
Comparative height size at age 10 0.0 0.3 0.5 0.7 0.0
Number of full sisters 1.1 1.3 2.4 -1.6 0.4
Suffer from ‘nerves’ 1.1 1.8 2.4 -1.1 1.6
Overall health rating 0.5 1.0 1.8 -1.3 -0.6
Chest pain or discomfort 0.2 0.3 0.5 0.3 0.7
Had major operations 1.1 1.3 2.5 -0.4 1.6
Age at last live birth 0.4 0.5 0.6 0.8 -0.7
Family relationship satisfaction 0.4 0.5 0.8 -0.4 0.9
Leg pain on walking 0.0 0.0 0.0 0.1 -0.1
Qualifications: NVQ or HND or HNC or equivalent 1.5 1.8 1.9 1.3 -1.4
Commuting to job workplace: Car/motor vehicle 1.5 1.8 2.7 -1.6 0.9
Illness, injury, bereavement, stress in last 2 years 0.2 0.3 0.4 0.6 -0.4
Medication: Aspirin 0.0 0.0 0.0 -0.0 -0.2
Supplements: Vitamin C 1.3 1.5 1.6 -1.3 1.2
Knee pain experienced in last month 0.6 0.9 1.0 0.9 -1.0
Hypertension (Self-reported) 0.2 0.5 0.7 0.9 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.0 0.0 0.1 0.3 0.1
Illnesses of father: Heart disease 0.3 0.4 0.7 -0.3 0.8
Illnesses of siblings: Diabetes 5.9 7.2 9.4 2.2 -3.1
Smoking status: Previous 0.0 0.0 0.0 -0.2 -0.0
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.0 0.0 0.1 -0.2
Whole body fat-free mass 0.3 1.5 3.0 0.1 -1.7
Leg fat-free mass (right) 0.3 1.7 3.1 0.5 -1.8
Arm fat percentage (left) 0.7 2.6 5.2 -0.2 -2.3
Average weekly red wine intake 0.4 0.6 1.1 -0.1 -1.1
Handedness (chirality/laterality): Left-handed 1.2 1.4 1.9 -1.0 1.4
Mood swings 1.4 2.5 4.8 -2.2 0.5
Loneliness, isolation 3.1 4.3 7.3 -2.7 1.1
Long-standing illness, disability or infirmity 1.1 1.8 3.2 -1.8 -0.5
Ever had bowel cancer screening 0.8 1.0 1.5 1.2 -0.6
Diabetes diagnosed by doctor 0.8 1.4 1.8 1.3 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 3.1 3.3 3.5 -1.9 1.8
Friendships satisfaction 0.5 0.6 1.0 -1.0 0.3
Qualifications: nursing, teaching 1.0 1.6 3.2 -0.1 1.8
Commuting to job workplace: Walk 4.4 4.7 9.3 3.0 -0.3
Eye problems/disorders: Cataract 0.6 0.7 0.8 -0.8 -0.9
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 0.6 -0.8 0.6
Medication for cholesterol 1.0 1.5 2.4 -1.5 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.4 -0.7 0.1
Back pain experienced in last month 0.1 0.2 0.2 -0.5 -0.4
Mineral and other dietary supplements 0.4 0.5 0.9 0.2 -1.0
Breast cancer (self-reported) 2.1 2.5 4.4 2.1 -0.8
Asthma (self-reported) 1.8 3.5 6.4 -2.5 0.8
Osteoporosis (self-reported) 0.5 0.7 1.1 1.1 -0.5
Osteoarthritis (self-reported) 0.7 0.9 1.6 -0.3 1.3
Medication: Aspirin 0.0 0.1 0.1 -0.3 -0.1
Medication: Gliclazide 1.1 1.3 2.6 -0.2 -1.6
Illnesses of father: None of the above (group 1) 0.5 0.6 1.3 -1.1 -0.1
Smoking status: Current 1.1 1.8 2.4 -1.6 1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.1 1.1 -0.1
Whole body water mass 0.3 1.5 2.9 0.2 -1.7
Leg predicted mass (right) 0.3 1.6 2.9 0.5 -1.7
Arm fat mass (left) 0.8 3.5 6.7 -0.6 -2.6
Number of self-reported non-cancer illnesses 0.3 0.4 0.9 -0.9 0.0
Average weekly champagne plus white wine intake 0.4 0.5 0.7 -0.8 0.6
Miserableness 1.0 1.7 3.2 -1.8 0.6
Guilty feelings 7.6 11.5 17.4 -4.2 2.4
Wears glasses or contact lenses 1.0 1.2 2.4 -1.5 -0.1
Ever taken oral contraceptive pill 0.2 0.2 0.4 -0.2 -0.6
Hearing aid user 0.1 0.1 0.1 0.1 -0.4
Mother’s age at death 0.9 1.1 2.1 0.5 -1.4
Financial situation satisfaction 0.7 0.8 1.2 0.6 1.1
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.3 -0.3 -0.6
Commuting to job workplace: Public transport 0.2 0.3 0.5 0.1 -0.7
Eye problems/disorders: Glaucoma 0.8 1.0 2.0 -1.4 -0.1
Medication: Blood pressure 1.3 2.5 4.4 2.1 -0.8
Pain type(s) experienced in last month: Hip pain 0.5 0.6 0.8 -0.6 0.9
Supplements: Fish oil (including cod liver oil) 1.5 1.9 3.7 -0.4 1.9
High cholesterol (Self-reported) 2.1 3.7 4.9 1.5 2.2
Medication: Bendroflumethiazide 0.2 0.3 0.7 0.8 0.0
Medication: Paracetamol 2.2 3.5 6.2 -2.5 0.8
Medication: Lisinopril 2.5 3.2 4.3 2.1 -1.5
Medication: Atorvastatin 1.6 2.0 2.5 -1.3 1.6
Illnesses of father: High blood pressure 0.3 0.4 0.6 0.8 0.5
Alcohol drinker status: Never 0.3 0.4 0.6 -0.8 0.4
Ever smoked 0.8 1.4 2.9 -1.7 0.1
Basal metabolic rate 0.3 1.8 3.5 -0.1 -1.9
Leg fat percentage (left) 1.9 6.8 8.7 -3.0 -2.2
Arm fat-free mass (left) 0.4 2.2 3.4 -1.0 -1.8
Number of operations (self-reported) 0.8 1.2 2.3 -0.3 1.5
Average weekly beer plus cider intake 0.0 0.0 0.0 -0.2 0.1
Irritability 1.1 1.9 3.8 -1.9 -0.1
Risk taking 4.8 7.0 10.3 -3.2 1.9
Ever had prostate specific antigen (PSA) test 0.9 1.1 2.0 1.4 -0.4
Fractured/broken bones in last 5 years 0.2 0.3 0.5 0.2 0.7
Age started oral contraceptive pill 0.1 0.1 0.2 -0.5 -0.2
Diastolic blood pressure, automated reading 0.5 1.4 1.7 1.1 -1.3
Ever depressed for a whole week 0.0 0.0 0.1 0.2 -0.3
Unable to work because of sickness or disability 1.1 1.5 2.7 -1.6 0.5
Commuting to job workplace: Cycle 0.4 0.4 0.7 0.9 0.4
Myopia 0.1 0.2 0.3 0.5 0.2
Vascular/heart problems diagnosed by doctor 0.0 0.1 0.2 -0.2 0.4
Cholesterol lowering medication 1.6 2.4 4.0 0.9 2.0
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 0.4 0.6 0.7
Pain experienced in last month 1.0 1.7 2.3 1.1 1.5
Supplements: Calcium 1.6 1.7 2.1 1.2 1.4
Basal cell carcinoma (self-reported) 0.5 0.6 1.0 -1.0 0.4
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.1 0.4 -0.3
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.5 -0.1 -0.7
Heart disease (siblings) 0.2 0.2 0.3 -0.3 -0.6
Alcohol drinker status: Previous 1.2 1.4 2.6 -0.3 -1.6
Pack years of smoking 0.1 0.2 0.4 -0.6 0.2
Impedance of whole body 0.1 0.4 0.7 -0.4 0.8
Leg fat mass (left) 1.3 5.2 6.0 -2.1 -2.4
Arm predicted mass (left) 0.3 1.7 2.8 -0.8 -1.7