Hub : Genes

STEAP3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0750 0.0230 4.7e-05 0.050 0.039 0.046 0.040 0.058 8.9e-07 1.3e-05 2.2e-06 1.1e-05 1.5e-07
2 GTEx Adipose Subcutaneous 0.1390 0.0420 1.1e-04 0.098 NA 0.068 NA 0.083 2.2e-08 NA 2.9e-06 NA 2.4e-07
3 GTEx Adipose Visceral Omentum 0.1720 0.0550 6.3e-04 0.128 NA 0.083 NA 0.124 3.9e-07 NA 4.2e-05 NA 5.7e-07
4 GTEx Adrenal Gland 0.1724 0.0700 9.0e-03 0.002 NA -0.008 NA 0.010 2.7e-01 NA 9.3e-01 NA 1.3e-01
5 GTEx Artery Aorta 0.1560 0.0610 3.0e-03 0.038 NA 0.012 NA 0.035 3.5e-03 NA 6.9e-02 NA 5.2e-03
6 GTEx Brain Cerebellum 0.4410 0.0980 4.0e-05 0.325 NA 0.278 NA 0.337 2.4e-10 NA 7.6e-09 NA 9.3e-11
7 GTEx Cells Transformed fibroblasts 0.1540 0.0470 2.9e-04 0.022 NA 0.026 NA 0.036 8.6e-03 NA 4.2e-03 NA 9.7e-04
8 GTEx Colon Transverse 0.3300 0.0720 8.6e-08 0.298 NA 0.260 NA 0.290 1.1e-14 NA 1.0e-12 NA 3.0e-14
9 GTEx Esophagus Mucosa 0.1970 0.0450 4.1e-07 0.147 NA 0.134 NA 0.141 4.8e-10 NA 3.0e-09 NA 1.1e-09
10 GTEx Lung 0.1344 0.0422 2.2e-04 0.000 NA 0.012 NA -0.001 3.1e-01 NA 3.9e-02 NA 3.8e-01
11 GTEx Skin Not Sun Exposed Suprapubic 0.2780 0.0630 1.4e-06 0.203 NA 0.203 NA 0.195 2.4e-11 NA 2.2e-11 NA 5.9e-11
12 GTEx Skin Sun Exposed Lower leg 0.2010 0.0450 1.9e-07 0.146 NA 0.164 NA 0.158 4.2e-12 NA 1.7e-13 NA 5.0e-13
13 GTEx Whole Blood 0.1120 0.0330 5.6e-05 0.054 NA 0.054 NA 0.062 1.1e-05 NA 1.0e-05 NA 2.4e-06
14 METSIM Adipose 0.2358 0.0438 0.0e+00 0.131 0.152 0.179 0.179 0.162 4.3e-19 4.1e-22 4.4e-26 4.4e-26 1.7e-23
15 ROSMAP Brain Pre-frontal Cortex 0.0888 0.0291 1.4e-04 0.035 0.026 0.031 0.025 0.021 2.1e-05 2.4e-04 6.0e-05 3.3e-04 9.1e-04
16 TCGA Colon Adenocarcinoma 0.0710 0.0380 3.8e-03 0.051 0.031 0.044 NA 0.031 6.5e-04 6.2e-03 1.4e-03 NA 6.5e-03
17 TCGA Kidney Renal Clear Cell Carcinoma 0.0507 0.0205 1.0e-04 0.038 0.032 0.023 NA 0.037 3.7e-05 1.4e-04 1.1e-03 NA 4.4e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Bipolar Disorder (2018) 1.0 1.5 4.4 1.5 0.4 0.7 0.2 2.1 -0.9 0.2 1.9 -1.4 0.1 -0.6 -0.7 1.8 1.4 2.0 1.2 0.7
Bipolar Disorder or Schizophrenia 1.0 2.3 5.4 1.9 1.6 1.7 0.3 2.0 -0.6 -0.3 2.3 -1.3 0.4 -0.4 -1.0 1.8 2.1 2.1 1.2 2.0
Depressed Affect (Nagel 2018) 1.9 4.0 10.2 -2.1 2.1 2.2 -1.2 -2.3 -2.0 -0.9 -2.4 2.3 1.3 1.8 2.3 -1.3 2.4 -3.2 -1.5 1.3
Depression (Nagel 2018) 1.6 2.4 6.6 -1.3 2.3 2.5 -1.0 -1.4 -0.9 0.5 -2.0 1.4 1.0 1.1 1.3 -0.7 2.6 -1.8 -0.7 1.7
Intelligence (Savage-Jansen 2018) 1.3 4.1 11.6 -3.0 -0.5 -0.6 -1.3 -2.1 -2.0 0.7 -3.4 2.3 -3.1 1.9 2.3 -2.2 -0.7 -1.7 -2.4 -0.8
Neuroticism (Nagel 2018) 1.8 4.3 10.0 -2.8 1.0 1.2 -1.2 -2.7 -1.7 -0.0 -2.7 3.2 0.5 2.5 3.1 -1.7 1.8 -2.9 -1.5 0.5
Schizophrenia (2018) 0.6 1.2 4.0 1.1 1.7 1.7 0.2 0.8 -0.1 -0.6 1.5 -0.6 0.4 -0.0 -0.7 0.8 1.6 1.0 0.7 2.0
Schizophrenia vs Biploar Disorder 0.4 0.5 2.2 0.9 0.1 -0.3 -0.1 0.8 0.1 -0.7 1.1 -0.5 1.5 -1.3 -1.1 0.5 0.4 0.1 0.5 0.1
Worry (Nagel 2018) 0.6 1.3 3.6 -1.5 0.2 0.4 -0.5 -1.9 0.4 -0.1 -1.8 1.7 0.5 0.8 1.5 -1.5 0.4 -1.6 -1.1 0.1
Alzheimer’s Disease (in mother) 1.8 2.1 5.1 -1.5 -0.2 -0.4 -2.3 -2.0 -1.6 -0.6 -1.8 2.0 -1.9 0.6 1.0 -1.9 -0.9 -1.1 -1.7 -1.0
Alzheimer’s Disease (in father) 1.6 1.7 4.4 -1.6 0.6 0.7 -2.1 -2.1 -1.1 -1.0 -1.8 0.8 0.2 0.5 0.7 -1.7 -0.5 -2.0 -1.6 0.3
Alzheimer’s Disease (including proxy) 2.5 3.6 8.3 -2.1 0.8 0.8 -2.9 -2.6 -2.1 -0.8 -2.5 2.7 -0.6 1.6 2.1 -2.3 0.2 -2.0 -2.3 -0.2
Crohns Disease (2017) 1.2 2.6 7.5 2.1 0.7 0.1 2.1 2.6 -1.6 1.3 2.2 -1.4 0.4 -0.1 -0.2 2.4 1.0 2.7 1.6 0.7
Irritable Bowel Disease (IBD) 0.4 1.0 2.8 1.5 1.6 1.1 1.1 0.8 -1.7 -1.4 1.1 -0.6 -0.2 0.1 -0.1 0.6 1.1 1.0 -0.3 0.9
Ulcerative Colitis (UC) 0.9 1.6 10.2 0.2 1.6 1.4 -0.1 -0.7 -1.4 -3.2 -0.4 0.8 -1.0 0.7 0.6 -1.1 0.8 -1.1 -2.0 0.7
Major Depression (MDD) 0.4 0.5 1.2 -0.4 0.7 0.8 0.1 0.1 -0.7 -0.7 1.1 0.2 -1.1 0.5 0.6 0.7 0.9 0.1 0.9 1.0
Reaction Time 1.0 1.9 4.5 -1.5 1.0 1.2 -2.0 -2.1 0.1 -1.1 -2.0 1.1 -0.9 0.2 0.5 -2.1 0.3 -1.5 -2.1 0.6
Verbal and Numeric Reasoning (VNR) 0.9 2.2 6.5 -1.9 0.3 0.1 -0.8 -1.9 -1.3 -0.7 -2.1 1.7 -2.5 1.1 1.7 -1.8 -0.4 -0.9 -2.2 -0.3
Breast Cancer 0.9 2.2 5.1 -1.8 -2.0 -2.3 0.1 -1.1 -1.0 0.6 -1.3 1.7 -1.2 1.9 1.5 -0.9 -1.8 -1.3 -0.4 -2.0
Ovarian Cancer 0.4 0.5 1.3 0.2 -0.6 -1.1 -0.2 0.2 -0.8 0.2 0.6 -0.5 -1.0 -0.8 -0.7 -0.1 -1.0 1.0 0.3 -1.2
Prostate Cancer 1.0 1.4 4.3 1.1 1.0 0.6 0.3 1.4 -1.2 1.3 1.5 -0.7 1.3 -0.5 -0.3 1.2 2.1 1.2 1.8 0.7
Age at First Birth 1.2 1.7 5.1 -1.8 -0.4 -0.9 -1.1 -1.6 -1.2 -0.7 -1.4 1.7 -2.3 0.6 0.9 -1.6 -0.4 -2.3 -0.4 -0.8
Bipolar Disorder (2011) 1.8 1.8 3.7 1.9 1.7 1.6 0.7 1.2 1.2 -1.0 1.5 -1.4 0.3 -0.7 -0.7 1.4 1.4 1.9 0.5 1.9
Body Mass Index (BMI) (2010) 0.5 0.7 2.8 0.8 1.1 1.0 -0.4 0.4 0.2 0.6 0.6 -0.4 1.7 -0.3 -0.1 0.7 1.4 -0.2 0.6 1.3
Coronary Artery Disease (CAD) 0.4 0.5 1.7 1.1 0.4 -0.1 -0.5 0.6 -0.8 -0.1 0.4 -0.9 0.2 -1.3 -1.1 0.6 0.2 0.8 0.8 0.1
Crohns Disease (2012) 1.0 1.5 4.5 0.5 -1.0 -1.5 0.8 1.8 -1.4 1.7 1.2 -0.5 -0.3 0.2 0.3 1.5 -0.4 2.1 1.9 -1.1
Mean Putamen Volume 0.5 0.6 3.2 -0.6 0.4 0.2 -0.4 -0.4 -0.3 -1.4 -1.1 0.8 -0.9 -0.0 0.2 -0.8 -0.6 -0.3 -1.8 -0.2
Fasting Glucose 0.6 0.7 3.8 0.8 -0.4 -0.3 -0.8 -0.2 1.9 -0.3 -0.5 -1.0 -0.5 -1.6 -1.2 -0.3 -0.3 -0.3 0.0 -0.0
HbA1C 1.0 1.1 2.8 -1.1 -0.2 -0.2 -1.0 -1.5 -1.7 -1.0 -0.4 1.2 -0.1 0.4 1.0 -1.6 -0.6 -1.6 -1.5 -0.6
HDL Cholesterol 0.2 0.4 1.9 0.1 0.1 0.3 -0.4 0.2 -1.0 0.0 -0.2 0.9 0.7 1.4 0.7 0.3 1.1 -0.1 -0.5 0.4
LDL Cholesterol 0.3 0.5 2.1 -0.9 -1.0 -1.1 0.3 -0.2 -0.5 -0.6 -0.4 0.5 -0.3 0.4 0.5 -0.5 -1.4 0.1 -0.1 -1.2
Lupus 1.2 1.9 4.0 1.2 -1.5 -1.4 1.3 1.2 1.8 1.6 1.8 -1.5 0.0 -1.6 -1.2 1.6 -0.7 0.4 2.0 -0.7
Neuroticism (2016) 0.4 0.6 2.3 -0.6 0.4 0.8 0.5 -1.2 0.7 0.2 -0.9 0.7 0.4 0.4 0.8 0.1 1.4 -1.5 -0.7 0.4
Primary Biliary Cirrhosis 0.7 0.9 2.4 0.7 -1.2 -1.5 1.5 1.4 -0.1 1.5 0.6 -0.6 0.3 -0.6 -0.6 1.0 -0.5 0.2 1.1 -1.3
Rheumatoid Arthritis 0.9 1.2 4.1 0.7 0.2 0.3 1.2 2.0 2.0 1.2 0.7 -1.2 0.6 -0.9 -0.9 1.4 -1.0 0.3 0.9 0.7
Schizophrenia (2014) 0.6 1.3 3.2 1.8 1.2 1.2 -0.3 1.1 -0.2 -0.9 1.8 -0.8 0.5 -0.9 -1.5 0.8 1.6 1.1 0.9 1.4
Triglycerides 0.0 0.1 0.2 -0.2 -0.4 -0.4 -0.4 -0.1 0.3 -0.1 0.0 0.2 0.4 -0.1 0.5 0.2 0.0 -0.1 0.5 -0.1
Type 2 Diabetes (T2D) (2012) 0.9 1.1 2.9 0.9 -1.5 -0.9 1.7 0.9 0.6 0.8 1.4 -0.4 -0.9 -0.6 -0.5 1.3 -0.1 1.5 1.4 -0.7
Ulcerative Colitis 1.1 1.6 3.9 -0.6 0.8 0.8 -1.2 -1.9 -1.3 -1.8 -1.2 1.0 -1.8 0.4 0.6 -1.9 0.4 -2.0 -1.4 0.0
Blood Eosinophil Count 0.3 2.4 3.9 1.7 -1.4 -1.9 2.0 1.9 0.9 1.1 1.9 -1.6 1.4 -0.9 -1.5 1.1 -1.3 1.8 1.5 -1.6
Blood Platelet Count 0.6 6.9 21.4 3.6 0.3 0.3 1.2 2.4 2.1 1.6 3.1 -4.3 -0.2 -4.6 -3.9 2.1 0.3 3.6 2.7 0.7
Blood Red Count 0.1 1.1 2.7 0.6 -1.3 -1.6 0.4 -0.1 1.1 0.4 0.8 -0.8 0.9 -0.9 -1.1 -0.2 -1.4 -1.3 1.6 -1.3
Blood White Count 0.3 2.0 7.3 0.4 -2.2 -2.2 -0.3 -0.5 0.7 -0.1 0.4 -1.0 0.4 -1.3 -1.9 -0.9 -2.5 0.7 1.1 -2.7
Heel T-Score 0.8 6.6 34.8 -2.9 -1.4 -0.6 -2.0 -3.3 -1.3 0.9 -3.0 2.6 -5.9 1.5 1.7 -3.5 0.0 -2.9 -2.3 -1.6
BMI 0.1 0.5 2.0 0.6 0.4 -0.2 -1.4 0.3 -0.7 0.3 0.3 -0.5 0.8 -0.7 -1.0 0.1 1.0 1.1 1.1 0.2
Height 0.1 1.9 6.6 1.9 0.2 0.3 0.2 0.9 2.6 1.1 1.1 -2.1 -0.7 -2.5 -2.2 0.6 -0.5 1.2 0.8 0.2
Waist Hip Ratio (WHR) 0.1 0.2 0.8 0.4 0.5 0.1 -0.5 -0.9 0.3 -0.2 -0.4 0.4 -0.8 -0.3 -0.1 -0.5 0.6 0.5 -0.8 0.3
Systolic Blood Pressure 1.4 7.0 11.6 2.7 -2.1 -2.4 2.6 3.4 2.2 1.7 3.4 -3.3 0.4 -3.3 -3.1 2.3 -1.7 3.3 3.0 -1.9
Smoking Status 0.1 0.3 1.0 -0.0 0.5 0.6 0.7 0.5 -0.2 -1.0 0.0 -0.0 0.9 0.6 0.2 0.2 0.6 0.8 -0.0 0.9
Allergy or Eczema 1.0 2.7 6.4 -2.1 -0.5 -0.2 -2.4 -2.4 -1.8 -1.6 -1.9 1.9 -0.8 1.1 0.7 -2.5 -1.1 -2.3 -1.2 -1.0
Cardiovascular Disease 0.3 1.2 3.1 0.0 -1.7 -1.8 0.5 0.4 0.7 1.5 0.6 -0.5 -0.1 -0.4 -0.2 0.3 -1.8 1.8 1.0 -1.5
Hypothyroidism (self reported) 0.4 0.9 3.6 -0.6 0.8 0.4 -0.8 -1.5 0.5 -1.6 -0.9 0.9 -0.0 0.4 0.1 -0.8 0.6 -1.2 -1.9 0.1
Respiratory disease 0.3 0.7 3.7 0.6 -0.4 -0.9 1.2 0.6 1.1 0.0 0.1 -0.8 1.9 -0.6 -0.7 1.2 -0.4 0.6 0.8 -0.4
Type 2 Diabetes (T2D) (2018) 0.1 0.2 1.4 -0.2 -0.3 -0.6 0.3 -0.0 -0.5 -0.0 -0.3 0.5 -1.2 0.0 0.5 -0.1 0.1 -0.3 -0.0 -0.4
Lung FEV1/FVC ratio 0.9 4.6 13.0 -2.5 -2.4 -1.9 -3.6 -2.3 -1.4 -1.0 -2.4 1.8 -3.5 -0.1 0.3 -2.9 -1.3 -1.4 -1.9 -2.4
Lung FVC 0.3 1.4 5.3 0.6 2.3 2.1 1.0 0.6 0.1 -0.1 0.2 -0.1 1.2 0.7 0.4 0.4 2.1 -0.4 -0.1 2.3
Neuroticism 2.0 4.7 10.6 -2.7 1.2 1.6 -1.2 -3.1 -1.2 -0.6 -2.9 3.1 0.5 2.6 3.1 -2.0 1.6 -3.2 -2.0 0.8
Chronotype (morning person) 1.0 2.2 11.0 0.2 3.3 2.9 -1.3 -0.4 -0.1 -0.9 -0.1 0.3 -1.2 0.7 0.6 -0.3 2.1 -0.0 -0.4 3.0
Hair Pigment 0.1 3.6 8.9 -1.8 2.0 1.4 -3.0 -2.2 -1.9 -0.2 -2.2 1.9 -0.7 1.7 1.3 -2.4 2.3 -1.8 -2.6 0.8
Tanning 0.1 0.8 3.4 0.6 0.8 1.1 -0.5 -1.0 -0.1 -1.2 -0.0 -0.0 -1.8 -0.2 -0.2 -1.1 0.6 -1.6 -0.5 1.1
Hand grip strength (left) 0.7 1.8 4.0 -1.2 -0.5 -0.2 -2.0 -1.8 -1.4 -1.3 -1.3 1.7 -0.8 1.2 1.2 -1.9 -0.5 -1.5 -1.8 -0.4
Number of treatments/medications taken 0.2 0.4 1.3 -0.5 0.8 0.2 -1.1 -0.2 -0.6 -0.5 -0.8 0.5 -0.2 0.6 0.4 -0.6 1.2 0.5 -0.4 0.5
Average weekly spirits intake 3.8 4.7 9.2 2.9 0.1 -0.3 2.1 2.4 3.0 1.5 2.5 -2.9 0.9 -2.8 -2.5 2.4 0.2 2.9 2.4 0.7
Sensitivity / hurt feelings 0.3 0.6 2.0 -0.8 -0.1 -0.0 -0.1 -0.3 0.1 1.3 -0.6 0.9 -0.1 1.2 1.3 0.6 1.4 -0.1 0.8 0.5
Frequency of depressed mood in last 2 weeks 1.2 1.6 4.1 -1.2 1.6 1.7 -0.9 -1.1 -0.9 0.2 -1.7 1.4 0.3 1.5 1.6 -0.2 2.0 -1.2 -0.3 1.5
Hearing difficulty/problems: Yes 0.1 0.2 1.3 0.3 -0.2 -0.3 0.3 0.5 -0.6 1.1 0.2 -0.2 0.5 0.2 0.3 0.5 -0.1 -0.1 0.2 -0.4
Relative age of first facial hair 0.4 0.7 2.5 -1.1 -0.3 -0.3 -1.1 -1.0 -0.3 0.6 -1.3 0.9 0.1 0.4 0.5 -0.9 -0.8 -1.1 -1.6 -0.5
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 4.1 0.9 1.9 1.8 0.2 -0.2 1.0 0.3 -0.5 -1.4 0.1 -0.5 -0.9 0.2 2.0 -0.5 0.2 1.8
Ever used hormone-replacement therapy (HRT) 1.5 2.0 4.8 -1.9 0.2 0.2 -1.1 -1.6 -1.4 -1.0 -1.8 2.2 0.8 2.0 1.9 -1.5 0.4 -1.5 -1.4 -0.2
Ever had hysterectomy (womb removed) 0.9 1.0 3.1 -1.2 0.1 0.1 -0.3 -0.1 -1.8 -0.6 -1.1 1.6 0.2 1.5 1.7 -0.5 -0.3 -1.1 -1.4 -0.6
Systolic blood pressure, automated reading 0.5 1.4 3.0 1.7 -0.1 -0.4 1.3 1.3 0.8 0.5 1.6 -1.6 -0.6 -1.6 -1.6 0.8 0.1 1.7 1.5 -0.2
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 4.1 -0.6 1.1 0.9 -2.0 -1.3 -0.9 -1.3 -0.6 0.6 -1.5 -0.3 -0.1 -1.4 1.1 -0.5 -0.7 0.6
Angina 0.5 0.7 2.0 0.5 1.4 1.0 1.1 0.7 0.3 0.0 0.4 -0.5 -0.4 0.7 0.2 0.9 1.4 1.2 -0.2 1.2
Medication for hormone replacement therapy 3.4 3.8 10.1 -2.8 0.3 0.7 -1.6 -3.2 -0.9 -0.8 -3.2 2.2 0.2 2.2 2.3 -2.3 0.2 -2.5 -2.2 0.2
Vitamin and mineral supplements 0.7 0.9 4.6 0.9 -0.2 -0.2 1.5 2.1 -0.5 1.2 1.1 -0.6 1.4 0.5 -0.0 1.0 -0.1 0.6 1.3 0.1
Supplements: Zinc 0.5 0.6 2.8 -0.0 -0.4 -0.7 -1.7 -0.4 -0.4 -1.5 0.1 -0.2 -0.6 -0.5 -0.8 -0.9 -0.9 0.1 -0.3 -0.9
Medication: Co-codamol 0.9 1.0 4.4 1.3 0.1 -0.2 0.5 1.4 0.3 -0.4 2.1 -1.2 0.6 -1.0 -1.1 1.2 0.3 0.6 1.6 0.3
Medication: Metformin 0.2 0.3 1.2 0.1 0.8 0.7 -0.6 -0.1 -0.8 -0.0 -0.3 0.3 -0.8 0.3 0.4 0.2 1.1 0.4 -0.0 1.0
Diabetes (father) 0.2 0.2 2.2 -0.1 0.3 0.2 0.4 -0.4 -0.1 0.3 -0.0 0.1 -1.5 0.0 0.1 -0.2 -0.4 -0.9 -0.1 -0.3
Diabetes (mother) 0.4 0.5 1.6 -0.6 -0.2 -0.4 -0.8 -0.3 -1.2 0.0 -0.9 1.2 -0.3 1.0 1.0 -0.5 -0.3 -0.3 -1.3 -0.5
Severe depression (siblings) 1.3 1.5 3.3 1.3 0.9 0.7 -0.1 1.0 1.1 0.7 1.5 -1.7 1.4 -0.6 -1.3 1.3 1.6 1.8 0.9 1.3
Pack years adult smoking proportion 0.7 1.1 3.6 1.9 0.8 0.6 -0.6 -0.1 1.0 -0.3 1.2 -1.4 1.5 -1.5 -1.9 0.1 0.7 0.6 0.5 0.4
Impedance of leg (right) 0.3 1.3 4.9 0.8 -0.8 -0.8 1.4 2.2 0.8 1.5 1.4 -0.9 1.3 0.0 0.1 2.0 -0.6 1.0 1.0 -0.1
Leg fat-free mass (left) 0.1 0.5 2.6 0.0 0.5 0.3 -1.6 -1.1 -1.0 -0.4 -0.8 0.2 -0.3 -0.4 -0.6 -1.2 0.3 -0.3 -0.3 0.0
Trunk fat percentage 0.6 2.4 7.6 1.8 0.0 -0.2 0.8 1.6 0.9 1.3 1.7 -2.1 2.5 -1.3 -1.6 1.8 0.9 1.6 2.8 0.4
Hand grip strength (right) 0.7 1.9 6.2 -0.7 0.1 0.2 -2.5 -1.5 -1.5 -1.8 -1.3 1.4 -0.8 0.1 0.3 -2.3 -0.5 -1.5 -2.2 -0.4
Townsend deprivation index at recruitment 1.7 2.3 10.0 -0.0 3.2 3.1 0.0 -0.5 -0.4 -2.1 -0.8 0.3 0.4 1.4 0.5 -0.5 1.7 0.4 -1.3 2.6
Current tobacco smoking 0.4 0.6 1.9 0.9 0.7 0.6 0.5 1.0 1.0 -1.4 0.9 -1.0 0.5 -0.3 -1.0 0.2 0.2 1.3 0.3 0.4
Average weekly fortified wine intake 1.4 1.7 4.9 -1.4 0.2 0.4 -0.2 -1.7 -1.5 0.6 -1.4 1.9 -1.0 1.7 2.2 -0.8 0.8 -2.2 -0.4 0.3
Maternal smoking around birth 0.2 0.3 0.9 0.3 0.2 -0.0 0.9 -0.2 0.5 -0.9 0.1 -0.5 -0.5 -0.9 -0.9 -0.4 -0.5 0.1 -0.5 -0.1
Fed-up feelings 0.4 0.7 2.5 -0.4 0.9 0.6 -0.4 -0.8 -1.6 -0.3 -0.7 0.8 1.4 0.9 0.8 -0.4 1.0 -1.4 -0.3 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 3.2 0.0 1.7 1.8 -0.2 -0.5 0.0 -1.3 -0.7 0.4 1.0 0.2 0.1 -0.7 1.1 -0.9 -1.1 1.4
Relative age voice broke 0.7 1.1 3.0 -1.2 -0.4 -0.6 -1.7 -1.1 -1.5 -0.1 -1.0 1.3 -0.7 0.4 0.7 -1.3 -1.0 -1.0 -1.4 -0.9
Taking other prescription medications 0.7 1.1 7.1 0.7 1.6 1.1 0.2 0.9 -0.5 0.6 0.4 -0.3 0.3 -0.1 0.1 1.3 2.7 0.6 0.7 1.8
Age when periods started (menarche) 0.4 1.0 3.3 -0.6 0.4 0.7 -1.4 -1.5 -0.1 -1.3 -1.3 0.7 -1.6 -0.3 0.2 -1.8 0.1 -0.6 -1.3 0.3
Bilateral oophorectomy (both ovaries removed) 0.9 1.1 3.6 0.2 1.9 1.9 0.6 0.8 -1.8 -0.5 -0.1 0.3 -0.1 1.4 0.7 0.1 1.4 0.1 -0.8 1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 2.0 0.3 0.4 0.5 -1.1 -0.4 -0.3 0.6 0.3 0.2 -1.0 -0.4 -0.4 -0.5 1.4 0.0 -0.4 0.3
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 3.9 -0.3 0.1 -0.1 -2.0 -0.9 -1.7 -0.9 -0.8 1.2 -0.8 0.7 0.4 -0.8 1.0 0.3 -0.6 -0.1
Qualifications: CSEs or equivalent 0.5 0.7 4.3 0.8 -0.1 -0.1 -0.0 1.0 0.2 2.1 0.8 -0.9 0.2 -0.4 -0.3 1.1 -0.3 1.3 1.0 0.1
Serious illness, injury or assault to yourself 1.2 1.4 4.5 -2.0 0.1 0.1 -0.4 -0.7 -1.4 0.2 -1.7 1.4 -2.1 1.6 1.7 -1.2 0.1 -1.0 -0.0 -0.4
High blood pressure 0.1 0.4 2.0 -0.0 -0.7 -0.6 0.8 0.2 0.3 0.8 0.5 -0.1 0.5 0.3 0.5 0.9 -0.2 0.5 1.4 -0.2
Hayfever, allergic rhinitis or eczema 0.7 1.6 5.5 -1.3 -0.7 -0.6 -2.3 -1.7 -1.5 -0.8 -1.3 1.1 -0.7 0.4 0.2 -2.0 -1.4 -1.6 -0.5 -1.0
Multivitamins +/- minerals 0.8 1.0 3.3 -0.7 0.9 0.8 -1.5 -1.8 -0.4 -1.5 -0.7 1.1 -0.6 0.4 0.7 -0.8 1.3 -0.3 -1.5 0.7
Stomach or abdominal pain in last month 0.4 0.5 3.2 -0.7 0.2 1.1 -0.5 -0.2 0.7 -1.8 -0.5 0.7 0.4 0.8 0.8 -0.5 0.4 -0.5 -0.5 0.3
Supplements: Glucosamine 0.3 0.4 2.2 -0.0 -1.2 -1.5 0.3 -0.0 1.0 0.7 0.5 0.3 0.7 0.0 0.2 0.0 -0.3 -0.1 0.4 -0.9
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.7 -0.3 0.8 1.3 -1.1 -1.1 0.4 0.2 -0.8 -0.1 -0.6 -0.4 -0.1 -0.8 1.1 -0.2 -1.1 0.7
Medication: Atenolol 1.8 2.2 5.1 0.6 -1.8 -2.1 1.3 1.2 1.6 1.1 0.5 -1.8 -0.9 -1.9 -1.8 0.8 -2.3 1.5 0.8 -1.5
Medication: Levothyroxine sodium 0.1 0.1 0.5 0.1 0.1 -0.2 0.1 0.3 0.6 0.2 -0.1 -0.0 0.6 0.0 -0.1 0.5 0.7 -0.1 -0.6 0.1
Sitting height 0.1 0.4 1.8 -0.5 -1.0 -0.7 -0.2 0.1 0.5 1.4 -0.5 0.2 -0.4 -0.2 0.2 0.1 -0.6 -0.8 -0.7 -0.8
Chronic bronchitis/emphysema (father) 0.3 0.3 0.9 -0.4 1.0 0.7 -0.5 -0.4 -0.6 0.2 -0.9 -0.2 -0.4 0.3 0.0 -0.4 0.7 -0.0 -0.9 0.8
High blood pressure (mother) 0.7 0.9 4.2 -0.2 -2.1 -1.9 0.1 0.6 -0.6 1.2 -0.0 0.3 0.3 -0.4 0.1 0.9 -1.0 0.5 0.5 -1.7
Body mass index (BMI) 0.2 0.7 2.7 0.6 0.6 0.2 -1.6 -0.4 -1.0 -0.6 -0.1 -0.4 1.6 -0.9 -1.0 -0.4 1.1 0.1 0.7 0.3
Impedance of leg (left) 0.5 2.7 7.6 1.2 -1.3 -1.3 1.9 2.8 1.6 2.1 2.0 -1.7 1.3 -0.7 -0.6 2.7 -1.0 1.3 1.6 -0.5
Leg predicted mass (left) 0.1 0.6 3.0 -0.0 0.6 0.5 -1.7 -1.2 -1.1 -0.5 -0.8 0.2 -0.3 -0.3 -0.5 -1.3 0.3 -0.3 -0.4 0.1
Trunk fat mass 0.3 1.2 4.5 1.3 -0.0 -0.3 0.1 0.9 0.4 1.1 1.0 -1.5 1.6 -1.1 -1.3 1.1 0.7 1.0 2.1 0.1
Waist circumference 0.2 0.6 2.3 1.0 0.3 -0.0 -1.2 -0.5 0.3 -0.3 0.1 -0.8 0.8 -1.5 -1.5 -0.5 0.5 0.3 0.5 0.0
Number of incorrect matches in round 0.5 0.9 4.4 0.3 1.1 1.1 1.5 0.2 2.1 -1.5 0.1 -0.1 -0.4 0.4 0.2 0.2 0.4 -0.0 -1.5 0.8
Past tobacco smoking 0.4 0.7 2.2 0.7 1.4 1.5 -0.9 -0.2 -0.2 -1.1 0.3 0.1 0.8 0.3 0.2 -0.4 0.2 -1.0 -0.8 1.4
Alcohol usually taken with meals 0.2 0.2 0.8 0.0 -0.4 -0.3 0.9 0.3 0.2 0.2 0.3 0.6 0.1 0.9 0.8 0.5 -0.0 -0.9 0.1 -0.1
Nervous feelings 0.3 0.5 1.7 -1.3 -0.6 -0.4 -0.2 -0.8 0.8 0.3 -1.3 0.8 -0.4 0.7 0.9 -0.9 -0.1 -0.7 -0.7 -0.6
Frequency of tenseness / restlessness in last 2 weeks 2.0 3.1 9.1 -1.7 1.4 1.2 -1.8 -2.0 -1.6 -1.8 -2.4 2.2 0.2 1.2 1.5 -1.8 1.2 -3.0 -2.2 0.7
Hearing difficulty/problems with background noise 0.6 1.0 3.3 -0.4 1.0 0.7 1.2 -0.1 -0.5 -0.3 0.0 1.0 0.7 1.8 1.7 0.3 1.3 -1.8 0.3 0.4
Hair/balding pattern: Pattern 2 0.3 0.4 1.9 0.4 -0.5 -0.9 -1.0 0.5 -1.2 -0.1 0.7 -0.1 -0.2 -0.1 -0.5 0.0 -0.0 1.4 0.6 -0.5
Had menopause 0.3 0.3 1.5 -0.5 0.0 -0.3 0.0 -0.2 -0.0 0.5 -0.6 0.7 1.2 0.5 0.5 -0.5 0.5 -0.8 -0.9 -0.3
Had other major operations 0.5 0.6 2.5 -0.6 -1.1 -1.0 -0.0 -0.6 -0.9 -0.3 -0.3 0.5 1.6 0.7 0.4 -0.4 -0.6 -0.8 0.1 -1.3
Forced vital capacity (FVC) 0.1 0.3 1.7 -0.6 0.3 0.2 -0.4 -0.1 -0.9 1.3 -0.8 0.1 0.5 0.4 0.5 -0.0 0.1 -0.8 -0.5 0.4
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 2.7 -0.1 -1.3 -1.1 -0.2 -0.5 1.2 1.6 0.0 0.0 -1.4 -0.8 -0.7 -0.4 0.1 -0.4 0.2 -1.1
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 1.0 -0.0 1.0 1.0 -0.4 -0.1 0.7 -0.6 -0.1 0.3 0.4 0.6 0.6 0.3 1.0 0.1 0.1 1.0
Qualifications: None of the above 1.0 2.1 4.8 1.7 0.5 0.6 1.6 1.4 2.2 -0.4 1.7 -1.6 1.0 -1.1 -1.3 1.9 1.6 1.9 1.4 1.1
Financial difficulties in last 2 years 0.3 0.4 1.8 0.6 0.2 0.1 -0.8 -0.1 -1.2 -1.3 0.5 -0.4 0.1 -0.8 -0.7 0.3 0.6 0.4 0.2 0.1
Mouth/teeth dental problems 1.4 2.1 6.2 -1.4 1.4 1.6 -0.6 -1.5 -1.2 -1.4 -1.3 1.6 -0.1 2.4 2.5 -0.6 1.0 -1.7 -0.6 1.6
Heart attack 0.6 0.8 2.0 0.4 1.0 0.9 0.7 0.6 0.8 1.2 0.4 -0.9 0.1 0.1 -0.3 1.0 1.4 1.0 1.2 1.3
Allergy 0.3 0.7 2.4 0.7 0.6 1.0 1.0 1.4 0.8 0.7 1.0 -0.5 0.3 0.0 0.2 1.5 1.2 0.9 -0.0 0.9
Pain all over the body in last month 0.8 0.9 3.0 -0.6 1.1 0.9 0.5 -0.4 0.7 -0.1 -1.0 0.8 1.6 0.7 0.9 0.3 1.7 -1.4 -0.1 1.0
Diabetes (self-reported) 0.4 0.5 1.2 0.9 -0.6 -1.0 0.8 0.8 -0.2 0.8 0.8 -0.8 -0.0 -0.9 -0.7 0.9 0.0 0.5 1.1 -0.5
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 3.2 -0.5 1.6 1.6 -0.3 -0.0 -0.0 0.1 -0.4 0.6 1.0 1.7 1.2 -0.2 1.8 -0.9 0.6 1.7
Medication: Ramipril 0.9 1.2 5.2 1.0 -0.4 -0.8 1.0 0.9 1.2 -0.3 1.5 -1.2 0.9 -0.9 -0.8 1.4 0.3 1.5 2.3 -0.0
Medication: Simvastatin 2.7 3.9 9.5 1.5 -0.7 -1.3 2.8 2.6 0.9 2.6 2.1 -2.2 -1.1 -1.0 -1.2 2.9 0.1 3.0 3.1 -0.1
Fluid intelligence score 0.3 0.6 2.8 -0.7 0.5 0.4 0.3 -0.8 -0.3 -0.4 -1.1 0.2 -1.7 -0.3 0.1 -0.8 -0.9 -0.7 -1.3 -0.0
Illnesses of siblings 1.0 1.4 4.6 -1.5 -0.4 0.0 -1.2 -0.8 -1.2 -0.3 -1.0 1.7 -2.1 1.1 1.7 -1.3 -0.8 -1.5 -0.6 -0.3
Neuroticism score 1.0 2.0 4.8 -1.8 0.8 1.1 -0.8 -1.9 -0.5 0.1 -2.1 2.1 0.3 1.6 2.2 -1.1 1.3 -2.0 -1.3 0.6
Weight 0.1 0.4 2.3 0.4 0.3 0.0 -1.5 -0.4 -0.7 -0.0 -0.4 -0.3 0.6 -0.7 -0.9 -0.6 0.6 -0.1 0.5 0.1
Impedance of arm (right) 0.7 3.5 10.9 1.8 0.6 0.8 3.3 2.7 2.0 1.0 2.4 -2.1 1.1 -0.1 -0.4 2.8 0.4 2.5 2.0 1.5
Arm fat percentage (right) 0.4 1.4 3.8 1.5 1.0 0.7 0.2 1.1 -0.2 -0.5 1.1 -1.5 1.9 -0.9 -1.2 1.1 1.4 1.3 1.9 1.1
Trunk fat-free mass 0.4 2.4 6.4 -1.3 0.1 -0.1 -2.5 -2.0 -1.9 -0.9 -2.3 1.6 -2.2 0.3 0.4 -2.3 -0.2 -1.6 -1.8 -0.8
Hip circumference 0.2 1.0 3.8 1.3 -0.2 -0.4 -0.5 0.8 0.3 0.1 0.7 -1.4 1.9 -1.5 -1.7 0.3 0.0 0.5 1.3 -0.3
Time employed in main current job 0.5 0.6 2.4 0.8 -0.8 -1.3 -0.3 -0.2 0.2 0.2 0.6 -0.4 1.6 -1.1 -1.0 -0.1 -0.4 0.1 0.8 -1.0
Alcohol intake versus 10 years previously 1.1 1.6 3.2 1.8 1.5 1.4 0.6 1.7 0.0 -1.7 1.6 -1.3 1.1 -0.5 -0.9 1.5 1.1 0.8 0.9 1.8
Father’s age at death 0.8 1.1 4.7 -0.1 -1.9 -1.8 -0.4 0.3 -0.7 1.0 0.1 0.8 -2.2 0.4 0.5 -0.0 -1.1 -0.7 0.2 -1.7
Worrier / anxious feelings 0.4 0.7 5.9 -0.7 -0.9 -0.8 0.1 0.2 0.6 2.4 -0.4 0.8 0.3 0.3 1.2 0.5 -0.1 0.0 0.5 -0.4
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 3.0 0.1 0.5 0.2 0.5 0.9 -0.6 0.2 0.0 -0.1 1.7 -0.0 0.1 0.9 0.4 -0.7 0.6 0.4
Falls in the last year 0.9 1.2 3.5 -1.9 -0.8 -0.3 0.3 -1.3 -0.2 -0.4 -1.0 1.6 -0.9 1.7 1.6 -1.2 0.2 -1.7 -0.5 -0.8
Hair/balding pattern: Pattern 3 1.6 2.4 8.5 -2.0 0.7 1.0 -0.6 -2.5 0.8 0.4 -2.2 1.7 -1.2 2.0 1.9 -1.1 0.6 -2.9 -0.9 0.8
Number of live births 0.4 0.6 1.5 1.1 0.5 0.6 0.6 0.1 0.6 -0.9 0.7 -1.0 0.8 -1.2 -1.0 0.7 0.6 -0.8 0.2 0.6
Forced expiratory volume in 1-second (FEV1) 0.2 0.5 2.1 -0.8 -0.6 -0.6 -1.3 -0.4 -1.0 1.4 -1.0 0.2 -0.3 -0.2 0.1 -0.6 -0.2 -1.1 -0.6 -0.5
Pulse rate 0.3 0.5 1.8 -0.2 -1.3 -1.0 -0.3 0.3 -0.7 0.2 -0.3 0.5 0.4 -0.1 0.4 -0.4 -1.3 0.4 -0.4 -1.2
Happiness 0.3 0.4 1.2 -0.7 0.3 0.4 0.4 -0.5 -1.0 0.6 -0.6 0.7 -0.7 1.1 1.0 0.0 0.6 -0.8 0.2 0.0
Noisy workplace 0.5 0.7 2.0 -1.2 -0.9 -0.8 -0.5 -1.1 -0.3 0.2 -1.4 1.1 -0.4 0.5 0.8 -0.9 -0.1 -1.1 0.4 -0.5
Qualifications: A levels/AS levels or equivalent 0.8 1.8 4.6 -1.8 -1.4 -0.7 -0.6 -0.9 -1.9 0.2 -1.6 1.6 -2.1 1.7 1.8 -0.6 -1.1 -0.3 -0.1 -1.2
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.6 2.1 -0.1 1.2 1.5 0.2 0.2 -0.3 1.1 -0.5 0.4 0.7 1.2 0.7 0.4 1.2 0.0 -0.2 1.1
Mouth/teeth dental problems: Dentures 0.7 1.1 2.3 1.2 -0.4 -0.4 1.5 1.1 1.0 1.2 1.1 -1.5 0.4 -1.0 -1.5 1.0 -0.2 1.4 1.1 -0.6
Asthma 0.4 0.8 5.8 0.4 -0.4 -0.8 1.2 0.8 0.7 0.2 0.0 -0.7 2.4 -0.5 -0.6 1.1 -0.3 0.8 1.0 -0.2
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 2.9 -1.7 -0.0 -0.3 -0.9 -0.5 -1.5 -0.3 -1.6 1.7 -1.6 1.7 1.5 -1.5 0.4 0.4 -1.1 -0.5
Medication: Cholesterol lowering 0.9 1.4 4.4 0.3 0.1 -0.1 2.1 1.3 1.2 2.0 0.5 -1.1 -0.2 0.3 0.3 2.0 0.8 1.2 2.0 0.7
Depression (self-reported) 0.3 0.3 1.5 -0.3 0.9 0.5 1.2 0.2 -0.0 0.6 -0.5 0.3 -0.4 0.8 0.6 0.2 0.0 -0.7 -0.3 0.2
Medication: Lansoprazole 1.8 2.1 7.2 1.4 0.6 0.5 1.7 2.1 0.9 -0.0 1.5 -1.3 2.7 -0.4 -0.8 2.5 1.5 0.6 1.6 1.1
Prospective memory result 0.6 0.7 3.9 -0.2 -0.7 -1.0 2.0 0.6 -0.2 -0.8 0.8 0.1 -1.4 0.6 0.2 0.6 -0.8 0.6 0.5 -1.2
Lung cancer (father) 0.5 0.6 2.0 0.4 -0.4 -0.3 1.1 1.4 0.2 1.0 0.5 -0.4 0.3 0.3 0.2 1.4 0.7 0.7 1.2 0.1
Illnesses of mother 0.6 0.7 2.5 -0.2 1.2 1.6 0.5 -0.3 1.3 1.0 -0.3 -0.3 0.5 0.3 0.3 -0.5 1.0 -1.3 0.1 1.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 1.2 0.3 0.3 0.1 -0.6 -0.0 -0.3 1.1 -0.2 -0.5 0.0 -0.8 -0.5 -0.1 0.5 -0.2 -0.5 0.3
Pulse wave Arterial Stiffness index 1.4 1.6 8.3 0.9 1.5 1.6 0.1 0.8 -0.5 -0.1 0.7 0.2 2.4 0.5 0.8 1.3 2.9 0.9 0.5 1.7
Impedance of arm (left) 0.5 2.5 9.6 1.0 -0.1 0.2 3.1 2.4 2.2 1.2 1.9 -1.8 0.6 -0.0 -0.2 2.2 -0.4 1.9 1.7 0.6
Arm fat mass (right) 0.2 0.6 1.9 0.8 0.5 0.2 -1.1 0.3 -0.6 -0.3 0.2 -0.9 1.4 -0.9 -1.2 0.1 0.9 0.9 1.2 0.4
Trunk predicted mass 0.4 2.4 6.2 -1.3 0.1 -0.1 -2.5 -2.0 -1.9 -1.0 -2.3 1.5 -2.2 0.3 0.4 -2.3 -0.3 -1.6 -1.9 -0.8
Standing height 0.1 0.9 6.5 -0.6 -0.9 -0.8 -0.3 -0.3 0.6 1.2 -1.0 0.1 -2.5 -0.1 0.0 -0.6 -1.4 -0.5 -0.6 -1.1
Length of working week for main job 2.1 2.3 6.7 1.9 -0.0 -0.0 2.2 1.9 1.0 1.3 2.6 -1.7 1.1 -0.7 -0.9 2.0 0.1 2.2 1.7 0.3
Exposure to tobacco smoke at home 0.7 0.8 2.8 0.2 -1.4 -1.1 1.4 1.4 -0.1 1.1 0.5 0.0 -0.3 0.2 0.2 1.1 -0.2 1.7 0.3 -0.9
Breastfed as a baby 0.3 0.4 2.5 0.3 0.1 0.3 -1.0 -0.4 0.0 -1.6 0.2 -0.0 -1.1 -0.5 -0.6 -0.6 0.3 -0.8 0.3 -0.2
Tense / ‘highly strung’ 0.6 1.0 3.0 -1.0 1.0 1.3 0.3 0.2 -0.0 -0.0 -1.2 1.5 -0.1 1.4 1.7 -0.6 1.4 -0.7 -0.8 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 3.4 -1.5 0.9 1.0 -1.4 -1.3 -0.7 -0.7 -1.9 1.5 -0.4 1.6 1.7 -0.9 0.9 -0.9 -1.2 0.9
Hair/balding pattern: Pattern 4 0.2 0.6 1.6 -1.0 0.9 0.7 0.0 -0.5 -1.3 -0.4 -1.1 0.8 0.1 0.8 1.3 -0.3 0.2 -0.5 -0.9 0.7
Birth weight of first child 0.3 0.6 1.8 -0.7 -0.7 -1.1 -1.2 0.1 -1.3 1.3 -0.2 0.1 -1.0 -0.6 -0.1 -0.4 -0.8 0.1 0.1 -0.9
Peak expiratory flow (PEF) 0.3 0.7 2.6 0.1 -1.5 -1.6 -0.1 0.4 -0.3 0.9 0.1 -0.3 0.1 -0.9 -0.6 0.2 -1.3 -0.7 0.7 -1.3
Pulse wave reflection index 0.8 1.0 5.0 -0.1 1.4 1.4 -0.4 0.2 -0.9 -0.2 0.3 0.5 1.0 1.1 1.2 1.0 2.2 0.5 0.3 1.4
Ever highly irritable/argumentative for 2 days 0.3 0.3 0.9 0.6 -0.9 -0.9 0.0 0.3 0.3 0.3 0.2 -0.3 0.8 -0.3 -0.9 -0.4 -0.7 0.0 0.7 -0.9
Loud music exposure frequency 0.3 0.3 1.3 -0.7 0.5 0.1 0.4 -0.9 0.5 0.6 -1.0 -0.2 0.6 -0.0 -0.1 -0.5 -0.1 -1.1 0.1 0.1
Qualifications: O levels/GCSEs or equivalent 0.2 0.2 1.4 -0.3 -0.5 -0.1 -0.8 -0.1 -0.7 -0.3 -0.3 -0.0 0.3 -0.0 0.1 -0.1 -1.2 0.6 -0.5 -0.6
Mouth/teeth dental problems: Bleeding gums 1.5 1.9 4.6 1.3 -2.1 -2.0 -0.7 1.6 0.6 1.1 1.2 -1.2 0.7 -2.1 -1.9 0.2 -1.7 0.7 0.9 -1.6
Blood clot in the leg (DVT) 0.2 0.3 2.6 0.6 -0.0 -0.3 0.2 -0.1 0.3 0.2 0.4 -0.6 1.6 -0.9 -0.6 0.1 0.3 0.5 0.4 0.3
Medication: Paracetamol 0.1 0.2 0.4 -0.4 -0.5 -0.3 -0.7 0.3 0.5 0.6 -0.5 0.4 -0.5 0.1 0.2 -0.3 0.0 0.3 -0.6 -0.3
Headache pain in last month 0.3 0.6 2.7 -0.1 0.8 1.0 -0.1 -0.3 1.5 -0.5 -0.6 -0.2 1.6 -0.0 -0.3 -0.6 0.7 0.2 -0.7 0.8
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.8 0.3 -0.4 0.0 -0.5 0.3 -0.4 -0.7 0.3 0.1 0.9 -0.6 -0.5 -0.3 -0.6 0.1 -0.7 -0.3
Glaucoma (self-reported) 1.4 1.7 3.3 -1.1 1.4 1.6 -0.9 -0.9 -1.6 -1.5 -0.9 1.3 -1.8 1.5 1.6 -0.7 1.8 0.1 -0.7 1.4
Gout (self-reported) 0.5 0.7 2.1 0.2 0.1 0.4 0.1 1.5 -1.3 1.3 0.6 0.6 0.7 1.0 1.2 1.1 -0.1 1.4 -0.1 0.4
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 3.0 -1.1 0.5 0.2 -0.9 -1.4 -0.5 -1.5 -1.2 1.3 -0.8 0.8 0.7 -0.8 0.6 -1.1 -1.7 -0.1
Medication: Amlodipine 0.6 0.9 3.0 -1.5 -0.6 -0.5 -0.2 -0.9 -0.5 1.1 -1.1 1.1 0.7 1.5 1.7 -0.1 0.9 -0.4 0.5 -0.2
Medication: Ventolin 100micrograms inhaler 1.0 1.2 4.0 1.2 0.3 -0.2 1.9 1.6 1.0 0.3 1.2 -1.3 0.7 -0.7 -0.6 2.0 0.8 1.3 1.2 0.4
Birth weight 0.5 1.2 3.1 1.2 0.8 0.8 -1.2 -0.1 1.4 0.5 0.7 -1.3 1.2 -1.6 -1.8 -0.2 1.7 0.5 0.5 0.8
Chronic bronchitis/emphysema (mother) 0.9 1.1 2.9 1.2 0.3 -0.0 1.4 1.5 0.4 0.6 1.5 -1.0 0.7 -0.3 -0.6 1.7 0.1 1.5 1.7 0.3
High blood pressure (siblings) 0.4 0.6 4.9 0.5 -0.1 -0.4 0.5 0.4 0.5 -0.2 0.5 -1.1 2.2 -0.8 -1.3 0.4 -0.0 0.8 0.2 -0.4
Forced vital capacity (FVC), Best measure 0.1 0.2 1.2 0.3 0.4 0.1 0.3 0.4 -0.6 1.1 -0.1 -0.4 0.6 -0.3 -0.2 0.1 0.1 -0.1 -0.5 0.3
Body fat percentage 0.7 2.6 7.6 1.9 0.4 0.0 0.6 1.7 0.6 0.8 1.8 -2.1 2.7 -1.3 -1.7 1.9 1.2 1.7 2.8 0.7
Leg fat percentage (right) 0.5 1.7 8.6 1.6 0.3 -0.1 -0.4 1.3 -0.2 0.1 1.3 -1.4 2.9 -1.1 -1.5 1.2 1.1 1.0 2.1 0.5
Arm fat-free mass (right) 0.3 1.6 6.7 -0.9 -0.4 -0.6 -2.6 -1.8 -1.1 -0.6 -1.7 0.8 -1.1 -0.6 -0.5 -2.1 -0.7 -1.2 -1.5 -1.2
Exposure to tobacco smoke outside home 0.7 1.0 3.2 -0.7 -1.3 -1.0 -1.3 -0.4 -0.7 -1.3 -0.4 1.2 -1.8 1.0 0.7 -1.0 -0.1 0.5 -0.7 -1.3
Comparative body size at age 10 0.2 0.4 1.3 1.0 0.9 0.4 0.5 -0.2 0.2 -1.1 0.7 -0.6 1.1 -0.7 -1.0 0.0 0.3 0.5 -0.0 0.3
Number of full brothers 0.4 0.5 1.7 0.1 -0.9 -0.8 0.3 0.2 0.5 0.9 0.4 -0.6 -0.5 -0.9 -0.8 0.6 0.4 0.0 1.3 -0.8
Worry too long after embarrassment 2.0 3.3 8.4 -2.7 -1.7 -1.5 -0.8 -1.3 -1.4 0.0 -2.1 2.9 -0.3 2.2 2.7 -1.7 -0.9 -1.9 -1.7 -1.9
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.6 5.5 0.3 2.3 2.3 0.8 -0.3 0.4 -0.1 -0.0 0.2 1.4 1.6 1.3 0.3 1.8 -0.4 -0.1 2.2
Wheeze or whistling in the chest in last year 0.9 1.5 3.9 1.6 -0.6 -0.8 2.0 1.8 0.8 -0.6 1.5 -1.5 0.6 -1.4 -1.4 1.1 -0.9 1.2 1.2 -0.8
Number of children fathered 1.6 1.7 6.2 -0.5 -2.1 -2.2 0.4 0.1 0.8 2.1 -0.5 -0.1 -1.3 -0.9 -0.7 -0.5 -1.6 -1.1 1.2 -2.5
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 1.2 0.5 0.2 0.0 -0.6 -0.1 1.1 -0.1 0.5 -0.4 -0.6 -0.3 -0.3 0.1 0.6 0.0 0.5 0.6
Age at first live birth 2.8 5.0 12.5 -3.3 -1.6 -1.3 -1.7 -2.2 -1.9 1.3 -3.1 2.7 -3.5 2.1 2.4 -2.0 -1.2 -2.3 -1.8 -1.7
Pulse wave peak to peak time 1.5 1.8 9.4 -0.6 -1.6 -1.7 0.1 -0.7 0.9 0.1 -0.6 -0.6 -2.4 -0.9 -1.1 -1.1 -3.1 -0.9 -0.4 -1.7
Health satisfaction 0.4 0.6 1.3 0.7 0.8 0.7 0.7 0.9 -0.0 1.0 0.4 -0.7 0.8 -0.3 -0.1 1.2 1.1 0.1 0.8 0.8
Shortness of breath walking on level ground 0.6 0.7 2.6 1.1 0.5 0.1 -0.3 0.9 0.2 -0.0 0.7 -1.0 1.6 -0.9 -1.1 1.1 1.0 0.2 0.8 0.5
Qualifications: College or University degree 0.8 2.6 6.7 -1.6 0.2 0.1 -2.2 -2.0 -1.5 -1.6 -2.2 1.7 -1.4 0.8 0.9 -2.6 -0.7 -1.8 -2.6 -0.3
Eye problems/disorders: None of the above 1.2 1.4 2.7 1.2 -1.1 -1.2 0.8 0.9 1.7 1.5 1.3 -1.4 0.9 -1.4 -1.5 1.3 -0.7 0.8 1.1 -0.7
Mouth/teeth dental problems: Loose teeth 2.6 3.1 10.4 -1.2 -0.0 0.2 -2.8 -2.1 -0.7 -3.0 -2.1 1.4 0.3 -0.4 -0.3 -3.0 -1.0 -0.7 -3.2 -1.1
Emphysema/chronic bronchitis 0.4 0.4 2.1 -0.5 0.2 0.3 0.3 -0.7 0.2 -1.1 -0.6 0.2 -1.4 0.5 0.5 -0.4 0.0 -1.4 0.1 0.1
Medication for pain relief, constipation, heartburn 0.2 0.4 1.5 0.1 0.2 0.2 0.1 -1.2 0.7 0.9 0.0 -0.2 1.2 -0.2 0.1 0.2 -0.0 -1.2 0.9 0.5
Neck or shoulder pain in last month 0.4 0.6 2.4 0.4 0.3 1.0 0.1 0.5 1.5 1.3 -0.6 -0.6 0.2 -0.0 -0.1 0.8 1.3 -0.4 0.2 1.1
Medication: Blood pressure 0.2 0.3 1.4 0.2 1.2 0.9 0.3 -0.3 0.1 0.5 0.2 -0.4 0.1 0.4 0.2 0.5 0.9 0.2 0.8 1.0
Angina (self-reported) 0.4 0.5 1.8 0.5 1.2 0.9 0.8 0.6 0.3 -0.1 0.4 -0.5 -0.5 0.6 0.1 0.8 1.4 0.9 -0.1 1.1
Migraine (self-reported) 5.1 6.4 15.4 -3.2 0.9 1.5 -2.2 -2.9 -2.3 -0.7 -3.9 3.4 -1.4 2.9 3.0 -3.1 0.4 -3.3 -3.0 0.4
Medication: Ibuprofen 1.7 2.1 5.5 -2.0 0.2 -0.0 -1.4 -1.1 -1.7 -0.6 -2.0 1.9 -2.4 1.7 1.7 -2.0 0.4 0.3 -1.4 -0.5
Medication: Allopurinol 0.2 0.2 0.7 0.2 0.3 0.5 0.7 0.7 -0.2 0.4 -0.1 0.2 0.4 0.3 0.4 0.2 -0.7 0.6 -0.8 0.1
Medication: Omeprazole 0.5 0.6 1.5 -0.5 0.2 0.1 -0.6 -0.1 -1.0 -1.2 -0.7 1.1 -1.0 0.7 0.3 -1.1 -0.5 -0.4 -1.2 -0.5
Medication: Seretide 50 evohaler 1.0 1.1 2.8 1.7 0.3 0.0 0.5 1.5 0.3 -0.6 1.1 -1.3 1.4 -1.6 -1.6 1.2 0.6 0.9 0.8 0.5
Mean time to correctly identify matches 0.9 1.8 3.8 -1.1 1.7 1.6 -1.5 -2.0 1.0 -1.4 -1.6 0.7 -1.0 0.2 0.3 -1.8 1.1 -1.2 -1.7 1.1
Heart disease (mother) 0.6 0.8 3.0 -1.1 -0.5 -0.6 -0.8 -0.8 -1.7 -0.8 -0.9 1.3 -0.5 0.7 1.0 -0.5 -0.2 -1.1 -0.5 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 2.4 -0.6 0.5 0.4 -1.4 -0.6 -1.5 -1.0 -0.2 0.7 0.2 0.7 0.7 -1.5 -0.6 -0.5 -0.8 0.3
Whole body fat mass 0.3 1.3 3.9 1.4 0.4 0.1 -0.2 0.9 0.1 0.6 0.9 -1.6 1.9 -1.3 -1.5 1.0 1.1 1.2 2.0 0.5
Leg fat mass (right) 0.3 1.2 5.1 1.4 0.5 0.1 -0.8 0.8 -0.2 0.1 0.9 -1.2 2.3 -1.1 -1.5 0.7 1.1 0.9 1.6 0.6
Arm predicted mass (right) 0.3 1.7 7.1 -1.1 -0.4 -0.6 -2.7 -1.8 -1.2 -0.3 -2.0 1.0 -0.9 -0.3 -0.2 -2.1 -0.7 -1.3 -1.4 -1.2
Pulse rate, automated reading 0.7 2.3 5.7 2.4 -0.9 -1.0 -0.2 1.6 0.9 0.1 2.1 -1.6 2.1 -2.3 -1.7 0.7 -0.7 2.4 0.7 -0.9
Alcohol intake frequency. 1.0 2.3 7.6 -1.0 1.3 1.6 -1.0 -1.1 -0.6 -2.8 -1.1 1.2 1.8 2.2 1.6 -1.3 0.9 -1.9 -1.6 1.3
Comparative height size at age 10 0.1 0.7 6.2 -0.6 -0.5 -0.6 -0.7 -0.9 0.2 0.3 -0.9 0.3 -2.5 -0.4 -0.1 -0.9 -0.7 -0.9 -0.1 -0.9
Number of full sisters 1.0 1.2 2.8 -1.7 -0.9 -0.6 -1.5 -1.2 -1.1 0.2 -1.5 1.2 -1.7 0.7 0.5 -1.3 -0.5 -1.3 -0.4 -1.0
Suffer from ‘nerves’ 0.7 1.1 3.8 -1.0 1.1 1.4 0.4 -2.0 0.6 -0.8 -1.6 0.9 -0.7 0.5 0.9 -0.8 0.5 -1.7 -0.8 0.7
Overall health rating 0.6 1.3 3.5 1.3 -0.3 -0.7 0.7 1.6 0.9 1.5 0.8 -1.6 1.0 -1.4 -1.4 1.1 0.4 0.6 1.9 -0.3
Chest pain or discomfort 0.3 0.4 1.8 -0.1 -0.7 -0.7 0.4 0.5 0.5 1.2 0.6 -0.4 0.1 0.0 0.0 0.9 0.3 -0.7 1.3 -0.6
Had major operations 0.8 0.9 3.5 0.3 0.8 0.9 -1.0 0.6 -1.7 1.6 -0.2 0.4 0.0 0.7 0.7 0.9 1.9 0.5 0.1 1.1
Age at last live birth 0.6 0.8 4.4 -1.1 -0.4 -0.1 -0.2 -0.7 -1.4 0.8 -0.9 0.8 -2.1 1.0 0.9 -0.3 -0.7 -0.7 -0.6 -0.5
Family relationship satisfaction 0.6 0.8 2.0 -0.8 0.6 0.7 0.4 -1.4 -0.2 -0.6 -1.0 1.2 -0.2 1.4 1.4 -0.7 0.9 -1.1 -0.8 0.4
Leg pain on walking 2.6 3.2 5.8 2.4 0.3 0.2 2.1 2.1 2.0 1.7 1.9 -2.3 1.4 -1.5 -1.6 2.4 1.0 2.3 2.3 0.8
Qualifications: NVQ or HND or HNC or equivalent 0.8 0.9 2.6 0.9 0.8 1.1 0.6 0.9 0.2 1.2 0.8 -0.9 1.6 -0.5 -0.5 1.0 1.2 0.9 1.1 1.0
Commuting to job workplace: Car/motor vehicle 0.6 0.6 2.2 -0.2 -1.4 -1.4 -1.1 0.1 0.5 1.5 -0.4 -0.2 -0.0 -0.6 -0.4 0.0 -0.7 -0.5 0.6 -1.1
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.7 -0.0 -0.6 -0.6 0.1 -0.1 0.5 -0.8 0.1 0.2 -0.1 -0.6 -0.4 -0.4 -0.8 0.1 -0.7 -0.6
Medication: Aspirin 1.2 1.6 4.3 1.7 0.1 -0.2 0.8 1.4 0.6 -0.9 1.9 -1.8 -0.4 -1.5 -1.9 1.4 0.1 2.1 1.2 0.3
Supplements: Vitamin C 0.7 0.9 3.0 -1.2 -0.1 -0.2 0.6 -1.4 0.5 -0.7 -1.3 0.6 -1.7 0.4 0.6 -1.0 -1.1 -0.9 -1.0 -0.8
Knee pain experienced in last month 1.7 2.6 10.4 0.5 -3.2 -3.2 -0.7 0.1 1.7 1.9 0.2 -0.6 0.4 -1.8 -1.7 -0.2 -1.1 0.3 1.3 -2.7
Hypertension (Self-reported) 0.1 0.2 0.8 -0.6 -0.4 -0.4 0.2 -0.5 -0.3 0.8 -0.2 0.4 0.1 0.8 0.9 0.3 -0.2 0.1 0.8 -0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 2.4 0.5 0.2 -0.1 0.8 1.1 -0.3 0.6 0.0 0.6 1.6 0.6 0.2 0.1 0.5 0.2 -0.1 -0.2
Illnesses of father: Heart disease 0.5 0.6 2.3 -0.0 1.5 1.2 0.1 -0.0 -1.0 -1.0 -0.3 0.6 0.0 0.9 0.8 -0.5 0.9 0.8 -0.8 0.7
Illnesses of siblings: Diabetes 0.7 0.9 4.6 1.4 0.4 0.3 2.1 0.6 1.2 -0.1 1.0 -1.2 0.3 -0.6 -0.6 1.4 0.2 0.5 0.5 0.6
Smoking status: Previous 0.4 0.6 2.2 -0.7 -1.4 -1.5 0.7 0.3 -0.2 1.4 -0.2 -0.1 -0.2 -0.5 -0.1 0.6 -0.2 0.7 0.7 -1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 2.7 -1.3 0.6 0.6 -0.6 -1.3 -1.5 -0.5 -1.6 1.1 -0.8 0.7 0.9 -1.4 -0.7 -1.3 -1.3 0.0
Whole body fat-free mass 0.2 1.4 4.8 -0.7 0.2 -0.0 -2.2 -1.7 -1.5 -0.7 -1.6 0.9 -1.4 -0.1 -0.1 -1.9 -0.1 -1.1 -1.2 -0.6
Leg fat-free mass (right) 0.1 0.4 2.0 0.2 0.4 0.2 -1.4 -0.9 -0.6 -0.3 -0.5 -0.2 -0.6 -0.6 -0.9 -1.0 0.2 -0.1 -0.1 -0.1
Arm fat percentage (left) 0.3 1.1 3.3 1.2 0.8 0.4 0.0 0.9 -0.1 -0.5 0.9 -1.3 1.8 -0.8 -1.2 0.7 1.2 1.1 1.7 0.8
Average weekly red wine intake 0.5 0.7 2.3 1.1 -0.2 -0.7 0.6 -0.0 0.7 -0.9 0.8 -0.6 -1.5 -1.2 -1.5 -0.3 -0.8 -1.1 -0.2 -0.6
Handedness (chirality/laterality): Left-handed 1.1 1.4 7.1 -0.2 0.7 0.6 1.2 0.0 -1.5 -0.8 0.1 1.3 -1.1 2.7 2.1 0.1 1.5 0.1 0.6 0.6
Mood swings 2.5 4.6 8.9 -2.6 1.7 2.0 -2.0 -2.2 -1.7 -1.0 -2.7 3.0 -0.0 2.5 2.8 -1.9 1.6 -2.7 -2.7 1.2
Loneliness, isolation 1.9 2.6 9.0 -1.8 0.1 0.3 -2.1 -3.0 -0.8 -1.9 -2.1 1.6 -0.1 0.5 0.6 -2.2 0.0 -3.0 -1.4 -0.2
Long-standing illness, disability or infirmity 0.3 0.4 4.3 -0.4 0.4 0.1 -0.2 0.5 -0.7 0.0 -0.8 0.2 -2.1 0.5 0.4 -0.2 0.8 -0.3 -0.3 0.2
Ever had bowel cancer screening 1.5 1.8 5.2 -1.8 -1.7 -1.4 -0.9 -1.4 0.8 0.9 -1.3 1.3 -1.2 0.5 0.9 -1.7 -0.8 -2.3 -0.4 -1.7
Diabetes diagnosed by doctor 0.2 0.3 0.8 0.6 0.0 -0.3 0.7 0.7 -0.5 0.7 0.4 -0.3 -0.7 -0.6 -0.2 0.9 0.6 0.3 0.6 0.2
Ever had stillbirth, spontaneous miscarriage or termination 1.4 1.5 9.8 -0.2 1.6 1.3 -1.1 -1.8 0.2 -3.1 -0.5 0.5 0.6 -0.2 -0.1 -1.0 1.4 -1.4 0.0 1.2
Friendships satisfaction 0.8 1.0 5.0 -0.9 -1.1 -0.7 1.1 0.2 -0.6 1.0 -0.4 1.2 0.5 2.2 1.8 0.1 -0.6 -0.2 0.1 -0.9
Qualifications: nursing, teaching 1.1 1.6 4.4 -2.0 -1.6 -1.8 -0.8 -1.1 -0.3 1.1 -1.1 0.9 -2.1 0.5 0.7 -0.9 -0.9 -1.3 -0.3 -2.0
Commuting to job workplace: Walk 0.4 0.5 2.9 0.5 -0.1 -0.2 1.7 1.1 0.6 0.1 0.7 -0.6 -0.3 0.0 -0.1 0.8 0.2 1.2 -0.2 0.2
Eye problems/disorders: Cataract 0.3 0.3 1.7 -0.4 0.1 0.4 0.9 0.9 0.1 -0.4 -0.2 0.0 0.4 1.3 0.8 0.5 -0.1 0.4 -0.2 0.4
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 2.5 0.9 -0.1 -0.4 0.1 0.8 1.3 0.3 0.8 -0.8 -0.2 -1.2 -1.0 0.5 0.0 1.6 0.2 0.2
Medication for cholesterol 0.2 0.3 1.8 0.6 0.8 0.8 -0.5 -0.2 0.3 -0.4 0.1 0.2 0.1 -0.1 -0.3 -0.4 0.9 -1.4 0.2 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.7 0.8 0.7 0.6 0.0 0.6 -0.1 -0.7 0.7 -0.7 -0.8 -0.3 -0.9 -0.3 0.5 0.2 0.1 0.5
Back pain experienced in last month 0.4 0.6 2.4 0.7 0.2 0.3 0.4 1.6 0.2 0.5 0.4 -0.5 1.4 0.1 -0.3 1.4 1.1 0.3 1.1 0.6
Mineral and other dietary supplements 0.6 0.8 2.9 -0.3 1.4 1.7 0.4 0.8 -0.7 0.8 -0.8 0.1 0.6 1.3 1.0 0.2 0.9 0.1 -0.3 1.4
Breast cancer (self-reported) 1.5 1.8 8.1 -0.7 -2.0 -2.3 -0.2 -0.3 -1.8 -1.0 0.3 1.1 -2.0 0.3 0.8 -0.7 -1.6 -0.4 -0.5 -2.8
Asthma (self-reported) 0.5 1.0 4.8 0.7 -0.3 -0.7 1.2 0.9 0.9 0.3 0.3 -1.0 2.2 -0.8 -0.9 1.2 -0.2 1.2 1.3 -0.1
Osteoporosis (self-reported) 0.7 0.9 2.6 1.0 0.8 0.7 0.6 0.9 0.8 -0.5 0.8 -1.2 1.6 -1.2 -0.8 1.6 0.3 -0.3 0.4 1.3
Osteoarthritis (self-reported) 0.6 0.8 1.9 0.4 1.3 1.4 -0.0 0.2 0.8 0.1 -0.4 -1.2 1.0 -1.3 -1.1 0.5 1.3 -0.1 -0.3 1.4
Medication: Aspirin 0.9 1.2 3.8 1.3 0.1 -0.2 0.7 1.4 0.5 -0.8 1.5 -1.6 -0.4 -1.1 -1.6 1.3 0.0 2.0 1.2 0.4
Medication: Gliclazide 0.4 0.4 2.7 0.2 -0.2 -0.5 0.3 0.6 -1.3 1.6 0.3 -0.5 0.5 -0.5 -0.2 0.8 0.3 0.4 1.0 0.1
Illnesses of father: None of the above (group 1) 0.3 0.4 1.5 0.2 -0.5 -0.3 0.2 0.5 0.6 0.0 1.1 -0.5 0.9 -0.3 -0.2 0.7 -0.6 -0.8 1.2 0.1
Smoking status: Current 0.3 0.5 2.5 0.6 1.0 1.0 0.3 0.3 0.8 -1.6 0.4 -0.6 0.4 0.1 -0.5 -0.2 0.6 0.7 0.0 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 3.5 -0.3 1.4 1.5 -0.8 -0.4 0.2 1.1 -0.7 0.2 0.1 0.4 0.7 0.2 1.9 -1.0 -0.1 1.7
Whole body water mass 0.3 1.5 5.4 -0.8 0.2 0.0 -2.3 -1.8 -1.6 -0.7 -1.7 1.0 -1.7 -0.1 -0.1 -1.9 -0.1 -1.1 -1.3 -0.6
Leg predicted mass (right) 0.1 0.4 2.0 0.2 0.4 0.1 -1.4 -1.0 -0.6 -0.3 -0.6 -0.2 -0.5 -0.6 -0.9 -1.1 0.1 -0.1 -0.2 -0.2
Arm fat mass (left) 0.1 0.5 1.3 0.7 0.3 -0.0 -0.9 0.2 -0.5 -0.3 0.2 -0.8 1.1 -0.9 -1.1 0.0 0.7 0.6 1.1 0.2
Number of self-reported non-cancer illnesses 0.6 1.1 5.0 0.9 1.5 1.3 0.5 0.8 0.8 -0.0 0.3 -1.2 2.2 -0.3 -0.9 0.9 1.1 0.8 0.5 1.6
Average weekly champagne plus white wine intake 0.8 1.1 2.7 -1.4 -1.3 -0.7 -1.2 -1.6 -0.1 0.0 -1.5 1.1 -0.1 0.9 0.8 -1.2 -1.0 -1.6 -0.1 -0.5
Miserableness 0.8 1.4 4.3 -0.5 2.1 2.0 -0.3 -0.7 -0.9 -0.6 -0.9 0.9 1.6 0.7 1.1 -0.2 1.7 -1.7 -0.3 1.6
Guilty feelings 0.9 1.3 2.9 -1.1 1.3 1.7 0.3 -1.1 0.5 -0.2 -1.3 1.5 0.4 1.4 1.6 -0.3 1.4 -1.2 -1.0 1.3
Wears glasses or contact lenses 0.4 0.4 2.6 -0.4 0.5 0.3 0.9 -0.0 -0.1 0.3 -0.3 0.9 -0.2 1.2 1.6 0.0 1.0 0.1 -0.3 0.3
Ever taken oral contraceptive pill 0.2 0.2 0.9 -0.7 -0.1 0.2 -0.4 -0.5 0.2 0.9 -0.8 0.4 -0.8 -0.0 0.5 -0.0 0.2 -0.0 -0.2 0.7
Hearing aid user 1.0 1.1 2.5 1.6 0.7 0.3 1.5 1.4 -0.2 0.0 1.3 -1.2 1.1 -0.6 -1.0 1.3 0.8 0.1 1.6 0.7
Mother’s age at death 0.9 1.1 4.3 -0.5 0.9 0.9 -0.0 -1.4 -0.0 -1.4 -0.9 1.2 -1.0 1.2 1.1 -0.7 0.5 -2.1 -0.9 0.9
Financial situation satisfaction 0.3 0.4 1.7 0.1 0.2 -0.2 -0.2 -0.4 0.9 -0.7 -0.2 -1.0 -0.8 -1.1 -1.3 -0.7 -0.4 0.3 0.1 -0.2
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.8 -0.1 0.3 0.2 0.4 0.3 -0.5 0.1 -0.3 -0.2 -0.9 0.3 0.3 0.4 0.2 0.3 -0.2 0.5
Commuting to job workplace: Public transport 0.2 0.3 2.2 -0.1 0.5 0.4 0.9 0.1 -0.5 -1.5 0.3 0.2 -0.1 0.6 0.2 -0.2 -0.5 -0.1 0.1 0.2
Eye problems/disorders: Glaucoma 2.3 2.7 6.0 -0.9 2.3 2.3 -1.7 -1.7 -1.8 -2.2 -1.3 1.2 -1.0 1.1 1.3 -1.2 2.4 -1.0 -0.9 2.1
Medication: Blood pressure 0.3 0.6 2.6 0.4 -0.0 -0.2 1.6 0.8 0.8 0.5 0.7 -0.7 0.2 -0.3 -0.2 1.1 -0.5 1.5 0.4 0.1
Pain type(s) experienced in last month: Hip pain 0.7 0.9 3.0 0.2 -0.3 -0.3 1.7 0.8 1.6 1.6 0.4 -0.7 1.5 -0.3 -0.1 1.2 0.0 -0.1 1.1 0.1
Supplements: Fish oil (including cod liver oil) 0.5 0.7 2.1 0.4 -1.1 -1.5 0.5 -0.2 1.0 0.0 1.1 -0.5 -0.1 -1.1 -0.8 0.8 -0.8 1.0 0.9 -1.0
High cholesterol (Self-reported) 1.1 2.0 7.2 0.2 -0.8 -0.9 2.2 2.0 0.3 2.7 1.2 -0.8 0.8 0.4 0.4 2.3 0.3 1.4 2.3 -0.0
Medication: Bendroflumethiazide 0.9 1.3 3.4 0.2 -1.4 -1.0 1.5 0.8 1.8 1.6 0.6 -1.5 -0.2 -1.0 -0.9 0.8 -1.7 0.6 1.3 -0.9
Medication: Paracetamol 0.4 0.6 1.6 -1.1 -0.2 -0.2 -1.0 -0.5 -0.1 0.2 -1.3 1.0 -1.2 0.7 0.8 -1.1 0.1 -0.1 -1.1 -0.4
Medication: Lisinopril 0.1 0.2 0.4 0.4 0.6 0.5 -0.6 0.4 0.3 -0.0 0.3 -0.2 -0.1 -0.2 -0.6 -0.2 -0.6 0.6 -0.3 0.4
Medication: Atorvastatin 1.1 1.4 4.6 0.3 2.1 1.9 0.9 0.8 0.4 0.0 0.4 -0.3 2.0 0.9 0.7 0.8 1.7 0.2 0.0 2.1
Illnesses of father: High blood pressure 0.3 0.4 2.1 0.5 -0.2 -0.4 1.3 1.4 0.6 0.5 0.6 0.2 0.2 -0.3 -0.3 0.8 -0.3 0.7 -0.6 -0.2
Alcohol drinker status: Never 2.4 2.9 11.5 -1.9 -0.3 -0.1 -1.8 -1.9 -1.5 -3.4 -1.5 2.3 -0.3 1.4 1.4 -2.6 -0.3 -1.1 -2.2 -0.9
Ever smoked 0.4 0.7 2.7 -0.1 -1.0 -1.0 1.3 0.9 0.6 0.9 0.3 -0.2 -0.9 0.0 -0.1 0.6 0.0 1.6 0.9 -1.0
Basal metabolic rate 0.2 0.9 4.3 -0.4 0.3 0.0 -2.1 -1.3 -1.4 -0.5 -1.3 0.5 -0.9 -0.3 -0.3 -1.5 0.0 -0.7 -0.7 -0.4
Leg fat percentage (left) 0.6 2.1 8.2 1.9 0.0 -0.4 -0.1 1.6 0.1 0.5 1.6 -1.8 2.9 -1.5 -1.9 1.5 0.9 1.1 2.4 0.2
Arm fat-free mass (left) 0.2 1.1 5.6 -0.4 0.1 -0.2 -2.4 -1.5 -1.3 -0.5 -1.5 0.6 -1.0 -0.6 -0.6 -1.6 -0.1 -0.9 -1.1 -0.7
Number of operations (self-reported) 0.3 0.4 1.2 0.7 -0.2 -0.3 1.0 1.0 0.1 0.1 0.4 -0.4 1.1 -0.2 -0.2 1.1 0.8 -0.4 0.7 -0.2
Average weekly beer plus cider intake 0.2 0.3 1.4 1.0 -0.2 -0.3 0.0 0.2 -0.0 -0.0 1.2 -0.7 -0.4 -0.4 -0.5 0.3 -0.5 0.9 -0.6 -0.6
Irritability 0.8 1.3 5.9 -1.7 0.4 0.7 0.5 -0.8 -0.5 0.6 -1.1 1.7 -0.8 2.0 2.4 0.3 1.2 -0.4 -0.1 0.4
Risk taking 0.6 0.8 2.9 -1.2 1.0 1.1 -1.2 -1.5 0.5 -0.1 -1.7 0.5 -0.0 0.4 0.5 -0.9 0.4 -0.6 -1.4 0.4
Ever had prostate specific antigen (PSA) test 0.9 1.0 3.1 0.8 0.8 0.9 -0.1 0.7 0.4 1.8 0.9 -0.4 1.1 0.2 0.1 1.2 1.3 1.3 1.4 1.4
Fractured/broken bones in last 5 years 1.7 2.2 10.5 1.3 1.3 1.2 1.7 1.8 0.8 0.3 1.6 -0.4 3.2 0.5 0.4 2.1 1.9 0.4 0.7 1.6
Age started oral contraceptive pill 0.4 0.5 2.3 0.2 -1.1 -0.9 0.2 0.7 0.5 1.5 0.8 -0.3 -0.2 0.1 -0.0 0.8 -0.6 0.9 0.4 -0.8
Diastolic blood pressure, automated reading 0.5 1.5 4.7 1.4 -1.3 -1.8 0.3 0.7 0.5 0.1 1.2 -1.1 -0.4 -2.2 -1.7 -0.0 -1.1 1.5 1.0 -1.6
Ever depressed for a whole week 0.4 0.4 1.6 0.7 -0.4 -0.8 -0.4 0.0 1.3 -0.4 0.4 -0.8 0.3 -1.0 -1.2 0.3 -0.5 0.6 0.4 -0.5
Unable to work because of sickness or disability 0.5 0.7 4.2 0.3 1.3 1.2 -0.1 -0.8 0.4 -2.1 0.1 -0.0 0.7 0.4 -0.1 -0.4 0.9 -1.0 -0.8 0.7
Commuting to job workplace: Cycle 0.2 0.3 1.2 -0.4 -0.6 -0.3 0.7 -0.9 0.9 -0.5 0.0 -0.0 -0.5 -0.0 0.0 -0.2 -1.1 -0.4 -0.2 -0.5
Myopia 0.2 0.3 1.1 -0.0 -0.3 -0.4 0.4 1.0 -0.8 1.1 0.1 0.1 -0.6 0.3 0.3 0.7 -0.1 0.3 0.4 -0.4
Vascular/heart problems diagnosed by doctor 0.4 1.1 3.7 -0.8 -0.1 -0.0 -1.4 -1.0 -0.7 -1.2 -1.2 1.0 -0.6 0.1 -0.0 -1.8 -0.6 -1.5 -1.9 -0.5
Cholesterol lowering medication 1.5 2.3 5.5 1.3 1.0 0.4 1.4 2.2 -0.8 1.9 1.7 -1.2 1.1 -0.3 -0.4 2.3 1.8 2.2 1.6 1.5
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 3.2 -0.8 0.0 -0.1 -1.5 -0.5 -1.2 -1.8 -1.1 1.3 -1.1 0.6 0.2 -1.7 -0.6 -0.6 -1.8 -0.8
Pain experienced in last month 0.9 1.6 7.8 -1.3 -0.6 -1.0 -0.6 -0.9 -2.1 -0.6 -0.3 0.9 -2.8 0.7 1.0 -0.9 -1.9 0.4 -1.2 -1.2
Supplements: Calcium 0.6 0.6 1.5 1.0 -0.6 -0.9 0.7 0.5 0.7 0.0 0.8 -1.0 0.5 -1.1 -1.1 0.5 -0.7 1.2 0.8 -0.6
Basal cell carcinoma (self-reported) 0.8 0.9 3.3 1.1 -0.9 -1.4 -0.4 0.7 0.0 -0.6 0.8 -0.9 0.7 -1.1 -1.8 -0.6 -1.3 1.0 -0.2 -1.2
Heart attack/myocardial infarction (self-reported) 0.5 0.7 1.8 0.4 1.0 1.0 0.6 0.4 0.9 1.0 0.3 -0.9 0.0 0.1 -0.2 0.8 1.3 0.9 1.1 1.3
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 2.1 0.3 -0.3 -0.4 0.1 -0.2 0.2 0.5 0.2 -0.5 1.4 -0.8 -0.5 -0.1 0.4 0.2 0.5 0.2
Heart disease (siblings) 0.6 0.7 1.7 -1.0 0.8 0.4 -0.1 -1.2 -0.8 -0.5 -1.2 1.3 0.5 0.8 0.9 -0.5 1.2 -0.9 -0.7 0.4
Alcohol drinker status: Previous 0.6 0.7 2.1 0.1 0.7 0.4 0.5 0.0 -0.7 -1.4 -0.2 1.0 0.8 1.5 0.9 -0.2 0.9 -0.9 -1.3 0.2
Pack years of smoking 1.0 1.4 4.7 2.2 0.9 0.7 -0.4 0.1 1.2 -0.4 1.4 -1.6 1.5 -1.7 -2.1 0.3 0.9 0.6 0.8 0.7
Impedance of whole body 0.6 3.2 7.9 1.4 -0.8 -0.5 2.8 2.8 2.4 1.9 2.3 -2.1 1.1 -0.6 -0.6 2.7 -0.8 1.7 1.9 0.1
Leg fat mass (left) 0.3 1.3 4.8 1.5 0.4 -0.0 -0.8 0.9 -0.2 0.4 1.0 -1.3 2.2 -1.2 -1.6 0.8 1.1 1.0 1.7 0.5
Arm predicted mass (left) 0.2 1.2 5.1 -0.6 -0.0 -0.4 -2.2 -1.5 -1.5 -0.5 -1.6 0.7 -1.2 -0.5 -0.4 -1.6 -0.2 -1.1 -1.2 -0.9