[Hub]/) : Traits : Heel T-Score : ← →

chr2:201,876,052-204,859,514

Best TWAS P=2.64e-46 · Best GWAS P=4.53e-143 conditioned to 0

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Artery Aorta	RP11-686O6.2	0.14	0.09	enet	10	0.07	1.7e-04	-7.376	-7.3	2.8e-13	0.03	0.80	0.01	TRUE
2	GTEx	Artery Coronary	RP11-686O6.2	0.13	0.09	lasso	2	0.04	1.3e-02	-7.422	-7.4	1.2e-13	0.04	0.20	0.05	FALSE
3	GTEx	Artery Tibial	RP11-686O6.2	0.14	0.08	lasso	8	0.11	8.5e-09	-7.332	-8.8	1.2e-18	0.07	1.00	0.00	TRUE
4	GTEx	Brain Cerebellar Hemisphere	RP11-107N15.1	0.26	0.02	enet	19	0.07	8.2e-03	-0.107	7.9	3.9e-15	-0.06	0.14	0.06	FALSE
5	GTEx	Cells Transformed fibroblasts	FAM117B	0.07	0.00	enet	15	0.03	2.7e-03	1.262	-5.2	2.6e-07	0.08	0.18	0.04	FALSE
6	GTEx	Cells Transformed fibroblasts	RP11-686O6.2	0.16	0.17	lasso	3	0.17	1.7e-12	-7.422	-7.7	1.8e-14	0.05	1.00	0.00	FALSE
7	GTEx	Esophagus Gastroesophageal Junction	ALS2	0.15	0.02	lasso	7	0.05	6.3e-03	-2.272	6.1	1.3e-09	0.03	0.14	0.05	TRUE
8	GTEx	Esophagus Gastroesophageal Junction	RP11-686O6.2	0.19	0.11	lasso	4	0.06	2.5e-03	-7.806	-7.7	1.0e-14	0.05	0.53	0.03	FALSE
9	GTEx	Esophagus Mucosa	FAM117B	0.13	0.09	lasso	4	0.09	2.1e-06	4.812	5.3	1.2e-07	0.06	0.59	0.05	FALSE
10	GTEx	Esophagus Mucosa	RP11-686O6.2	0.07	0.05	lasso	2	0.02	1.0e-02	-7.794	-7.9	3.9e-15	0.06	0.46	0.02	TRUE
11	GTEx	Esophagus Muscularis	RP11-107N15.1	0.19	0.02	enet	25	0.12	8.9e-08	9.965	7.6	2.5e-14	0.00	0.31	0.10	FALSE
12	GTEx	Esophagus Muscularis	RP11-686O6.2	0.18	0.11	lasso	5	0.10	7.9e-07	-7.304	-6.6	3.6e-11	0.04	0.98	0.00	FALSE
13	GTEx	Lung	RP11-686O6.2	0.19	0.14	lasso	7	0.13	6.4e-10	-7.283	-6.3	2.8e-10	0.01	1.00	0.00	FALSE
14	GTEx	Muscle Skeletal	NOP58	0.06	0.01	lasso	3	0.00	1.2e-01	-7.446	-7.7	1.6e-14	0.04	0.83	0.01	FALSE
15	GTEx	Muscle Skeletal	RP11-686O6.2	0.05	0.03	lasso	2	0.03	5.1e-04	-7.625	-7.6	2.3e-14	0.05	0.50	0.04	FALSE
16	GTEx	Nerve Tibial	RP11-686O6.2	0.07	0.05	enet	8	0.05	1.9e-04	-7.304	-6.5	1.1e-10	0.03	0.78	0.04	FALSE
17	GTEx	Pancreas	ICA1L	0.17	0.07	lasso	8	0.10	4.9e-05	-7.771	7.2	5.7e-13	-0.04	0.17	0.10	TRUE
18	GTEx	Stomach	RP11-686O6.2	0.13	-0.01	enet	12	0.01	6.5e-02	-7.823	-7.0	3.0e-12	0.10	0.12	0.12	FALSE
19	GTEx	Thyroid	RP11-686O6.2	0.10	0.07	enet	17	0.09	3.7e-07	-7.304	-6.8	8.9e-12	0.07	1.00	0.00	FALSE
20	METSIM	Adipose	FZD7	0.06	0.02	blup	403	0.03	3.5e-05	12.389	14.3	2.6e-46	-0.11	0.91	0.01	TRUE
21	METSIM	Adipose	RP11-686O6.1	0.02	0.01	bslmm	339	0.01	1.2e-02	4.050	-7.1	1.7e-12	0.05	0.08	0.03	FALSE
22	METSIM	Adipose	RP11-686O6.2	0.03	0.04	lasso	1	0.03	1.2e-05	-7.612	-7.6	2.7e-14	0.05	0.92	0.00	TRUE
23	NTR	Blood	NOP58	0.02	0.01	blup	359	0.01	2.4e-04	-7.612	-6.2	6.0e-10	0.07	0.54	0.02	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	CYP20A1	0.04	0.00	enet	25	0.02	1.9e-03	2.462	-5.8	5.5e-09	0.03	0.06	0.24	FALSE
25	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ABI2	0.04	0.04	enet	9	0.04	5.2e-04	6.577	8.0	1.1e-15	-0.05	0.08	0.06	TRUE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MPP4	0.05	0.05	lasso	3	0.04	1.3e-05	-4.961	-5.2	2.3e-07	-0.01	0.00	0.99	FALSE
27	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FZD7	0.09	0.11	lasso	3	0.09	5.1e-06	10.675	10.7	1.3e-26	-0.06	0.10	0.89	FALSE
28	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ICA1L	0.09	0.04	blup	59	0.03	9.6e-03	5.230	7.4	1.4e-13	-0.05	0.01	0.84	TRUE
29	The Cancer Genome Atlas	Lung Adenocarcinoma	NOP58	0.02	0.02	blup	32	0.03	4.8e-04	-7.582	-5.9	3.8e-09	0.06	0.02	0.74	FALSE
30	The Cancer Genome Atlas	Lung Adenocarcinoma	WDR12	0.04	0.02	lasso	2	0.02	1.4e-03	4.779	5.6	2.5e-08	-0.02	0.02	0.03	FALSE
31	The Cancer Genome Atlas	Prostate Adenocarcinoma	NOP58	0.05	0.06	lasso	4	0.05	1.3e-05	-7.794	-7.8	8.1e-15	0.06	0.03	0.97	FALSE
32	The Cancer Genome Atlas	Rectum Adenocarcinoma	ABI2	0.61	-0.01	blup	64	0.09	4.6e-03	0.037	-7.5	8.3e-14	0.00	0.01	0.40	FALSE
33	The Cancer Genome Atlas	Thyroid Carcinoma	FZD7	0.04	0.00	blup	62	0.02	8.6e-03	11.403	8.9	8.2e-19	-0.05	0.01	0.87	FALSE
34	The Cancer Genome Atlas	Thyroid Carcinoma	NOP58	0.03	0.03	blup	32	0.02	2.0e-03	-7.773	-5.8	8.1e-09	0.04	0.02	0.83	FALSE