Hub : Genes

FAM117B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1320 0.0410 5.3e-10 0.088 0.099 0.102 0.099 0.110 8.2e-11 4.1e-12 2.1e-12 4.1e-12 2.7e-13
2 GTEx Cells Transformed fibroblasts 0.0670 0.0310 5.4e-04 -0.002 NA 0.029 NA 0.008 4.6e-01 NA 2.7e-03 NA 7.2e-02
3 GTEx Esophagus Mucosa 0.1280 0.0550 6.3e-04 0.090 NA 0.086 NA 0.086 1.3e-06 NA 2.3e-06 NA 2.1e-06
4 GTEx Heart Atrial Appendage 0.1350 0.0710 3.4e-03 0.005 NA -0.006 NA -0.005 1.8e-01 NA 8.7e-01 NA 6.7e-01
5 GTEx Pancreas 0.1350 0.0590 2.8e-03 0.060 NA 0.069 NA 0.061 1.6e-03 NA 7.6e-04 NA 1.4e-03
6 GTEx Whole Blood 0.0630 0.0280 1.4e-03 0.062 NA 0.046 NA 0.056 2.4e-06 NA 4.3e-05 NA 7.1e-06
7 METSIM Adipose 0.1018 0.0384 8.8e-08 0.063 0.045 0.047 0.052 0.057 9.6e-10 2.3e-07 1.3e-07 2.4e-08 5.9e-09
8 NTR Blood 0.1660 0.0348 0.0e+00 0.126 0.140 0.139 0.145 0.148 1.7e-38 9.4e-43 1.9e-42 1.7e-44 2.6e-45
9 YFS Blood 0.4670 0.0470 0.0e+00 0.525 0.560 0.566 0.567 0.567 2.4e-206 4.4e-227 2.8e-231 2.2e-231 1.7e-231
10 TCGA Breast Invasive Carcinoma 0.0721 0.0325 2.4e-03 0.005 0.013 0.023 NA 0.004 3.0e-02 7.9e-04 1.5e-05 NA 5.2e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 1.2 1.8 3.7 -1.8 0.7 -0.1 -1.9 -1.1 -1.2 -1.6 -1.9 -1.3 0.4
Bipolar Disorder or Schizophrenia 0.4 0.9 5.3 -0.6 -1.3 -0.1 -2.3 -0.4 -0.6 -0.6 -0.3 -0.1 0.7
Depressed Affect (Nagel 2018) 3.8 8.0 14.9 3.8 -2.2 -2.1 0.6 2.7 3.2 2.7 2.6 3.0 -3.9
Depression (Nagel 2018) 1.6 2.3 9.9 1.8 -1.9 -1.6 -1.0 0.8 1.0 0.7 0.5 0.9 -3.2
Intelligence (Savage-Jansen 2018) 0.9 2.8 13.9 -1.3 3.7 2.3 0.0 -0.3 -0.5 -0.8 -1.6 -1.9 0.3
Neuroticism (Nagel 2018) 2.7 6.3 13.7 3.2 -2.6 -2.5 0.2 2.7 2.5 1.9 1.9 2.3 -3.7
Schizophrenia (2018) 0.5 1.1 5.3 0.7 -2.3 0.0 -1.4 0.4 0.2 0.6 1.2 0.9 0.5
Schizophrenia vs Biploar Disorder 2.7 3.5 6.3 2.5 -1.9 -0.3 1.2 1.8 1.6 2.1 2.5 2.3 -1.2
Worry (Nagel 2018) 2.5 5.3 9.3 2.5 -2.6 -1.9 0.8 3.0 2.7 2.1 2.0 2.1 -2.4
Alzheimer’s Disease (in mother) 0.8 0.9 3.2 0.5 -1.5 -1.5 -0.7 0.1 -0.1 -0.5 -0.7 -0.2 -1.8
Alzheimer’s Disease (in father) 1.7 1.8 8.4 1.6 2.4 0.7 0.7 -0.0 0.3 0.5 -0.1 -0.3 -2.9
Alzheimer’s Disease (including proxy) 1.6 2.3 12.6 2.1 -0.2 -2.0 -0.4 0.7 0.9 0.5 -0.1 0.6 -3.6
Crohns Disease (2017) 6.0 13.2 22.0 -4.3 1.1 1.5 -3.8 -4.2 -4.7 -4.5 -4.1 -4.3 0.5
Irritable Bowel Disease (IBD) 3.3 7.8 15.2 -3.2 0.5 1.3 -2.9 -3.5 -3.9 -3.5 -2.9 -3.1 0.9
Ulcerative Colitis (UC) 0.5 0.9 2.5 -0.9 -0.1 0.4 -0.9 -1.4 -1.6 -1.1 -0.7 -0.7 1.0
Major Depression (MDD) 0.4 0.4 1.1 1.0 0.1 -0.2 0.4 0.6 0.8 0.8 0.6 0.5 -0.8
Reaction Time 1.8 3.5 6.2 -2.2 -0.6 1.3 -2.2 -1.2 -2.2 -2.3 -2.3 -2.5 0.6
Verbal and Numeric Reasoning (VNR) 1.2 2.9 17.6 -1.2 4.2 2.4 1.1 -0.1 -0.2 -0.2 -0.9 -1.4 0.6
Breast Cancer 0.8 2.0 8.5 -1.1 1.9 2.9 1.4 -1.2 -0.7 -0.2 -0.1 -0.8 1.5
Ovarian Cancer 2.5 3.3 12.3 -2.2 -0.4 2.5 0.1 -1.6 -1.6 -1.4 -0.9 -1.3 3.5
Prostate Cancer 0.5 0.7 1.3 0.9 -0.8 -1.0 0.1 0.8 0.8 0.8 0.8 1.0 -1.1
Age at First Birth 0.5 0.7 1.9 -1.4 -0.8 0.1 -1.1 -0.3 -0.5 -0.9 -1.0 -0.9 0.8
Bipolar Disorder (2011) 1.6 1.6 4.6 -1.3 2.1 1.6 -0.3 -1.0 -0.9 -0.8 -1.3 -1.4 0.7
Body Mass Index (BMI) (2010) 0.5 0.7 3.5 1.1 1.3 0.2 -0.1 0.1 -0.1 0.1 -0.2 -0.4 -1.9
Coronary Artery Disease (CAD) 4.0 4.8 15.8 -4.0 0.4 1.6 -0.8 -1.6 -1.5 -2.0 -2.2 -2.1 3.4
Crohns Disease (2012) 4.4 7.1 12.0 -3.0 0.2 1.1 -2.8 -2.8 -3.5 -3.5 -3.3 -2.9 -0.9
Mean Putamen Volume 0.7 0.8 2.0 1.1 0.3 -1.0 0.1 1.4 1.3 0.8 0.3 0.2 -1.2
Fasting Glucose 0.8 0.9 3.6 1.4 -0.4 -1.9 0.3 0.3 0.6 0.9 0.8 0.8 -0.8
HbA1C 0.9 1.0 2.1 -1.0 0.7 0.0 -1.2 -0.9 -0.9 -1.3 -1.5 -1.3 -0.3
HDL Cholesterol 2.8 4.7 8.3 2.2 -1.7 -2.2 1.6 2.8 2.9 2.2 2.1 2.5 -0.4
LDL Cholesterol 2.1 3.3 12.5 2.5 0.3 -2.4 -0.8 1.6 1.6 1.4 0.5 0.7 -3.5
Lupus 2.6 3.9 11.9 -1.2 2.3 3.5 1.2 -1.6 -1.9 -1.5 -1.7 -2.1 -1.7
Neuroticism (2016) 0.5 0.7 4.4 1.5 -0.2 -0.2 -0.1 0.5 0.2 0.1 -0.2 -0.4 -2.1
Primary Biliary Cirrhosis 0.6 0.9 2.0 1.1 0.3 -0.4 0.8 0.3 0.2 0.9 1.4 1.3 1.4
Rheumatoid Arthritis 1.9 2.6 4.9 1.9 0.7 -0.3 0.7 1.9 2.2 2.2 1.9 1.9 0.2
Schizophrenia (2014) 0.5 1.2 5.0 0.4 -2.2 -0.1 -1.2 0.4 0.3 0.6 1.2 1.2 1.2
Triglycerides 1.5 2.5 5.3 2.3 1.3 -1.2 0.5 2.0 2.0 1.8 1.0 1.0 -1.6
Type 2 Diabetes (T2D) (2012) 1.5 1.8 5.9 1.4 1.7 0.5 2.2 0.5 0.7 0.7 0.7 0.4 -2.4
Ulcerative Colitis 0.2 0.2 1.5 -0.1 0.1 -0.0 0.7 -0.2 -0.2 0.1 0.1 0.3 1.2
Blood Eosinophil Count 0.9 7.0 19.8 4.5 -0.5 -1.6 1.3 3.0 2.4 3.2 3.0 3.2 -1.1
Blood Platelet Count 0.6 6.5 38.6 2.6 6.2 0.6 0.3 2.7 1.9 1.9 -0.2 -0.3 -2.0
Blood Red Count 0.2 2.2 8.3 -1.0 2.6 0.8 2.9 1.1 1.0 0.8 0.8 0.3 1.4
Blood White Count 2.0 14.8 30.6 4.7 -1.3 -2.2 2.2 4.2 4.5 4.7 4.8 5.5 -0.3
Heel T-Score 0.9 7.2 28.0 -1.2 -5.2 5.3 1.9 -1.7 -0.1 0.5 1.5 0.9 2.5
BMI 0.9 5.3 34.5 0.9 5.9 1.8 1.0 -0.7 -0.7 -0.6 -1.4 -1.9 -2.7
Height 0.4 7.8 27.2 -5.2 -0.6 3.4 -1.0 -1.7 -2.2 -2.5 -3.1 -3.1 2.0
Waist Hip Ratio (WHR) 0.6 2.6 6.2 1.8 -0.2 -2.5 -1.9 2.3 1.8 1.4 0.4 1.2 -1.2
Systolic Blood Pressure 1.0 5.0 11.0 0.3 -3.3 -3.0 -0.0 1.4 1.8 2.0 2.6 2.9 2.2
Smoking Status 1.4 3.4 10.1 2.3 -3.2 -2.0 -1.2 0.6 0.5 0.4 0.9 1.3 -3.1
Allergy or Eczema 5.5 14.3 24.0 4.8 -0.3 -1.6 4.4 3.9 4.2 4.9 4.4 4.6 0.5
Cardiovascular Disease 2.8 9.3 14.9 3.4 0.8 -3.4 2.5 3.9 3.8 3.5 2.6 3.3 -2.0
Hypothyroidism (self reported) 0.6 1.4 4.8 -0.8 0.7 0.8 -0.9 -2.2 -2.0 -1.1 -0.8 -0.9 0.5
Respiratory disease 4.4 9.7 22.7 4.8 0.6 -1.5 1.8 3.4 3.7 4.1 3.5 3.5 -1.6
Type 2 Diabetes (T2D) (2018) 1.0 1.8 3.1 1.8 1.7 0.2 1.3 0.6 1.2 1.6 1.8 1.5 -1.0
Lung FEV1/FVC ratio 0.6 2.9 12.7 1.6 2.8 -0.8 0.2 -0.3 -0.6 -0.6 -1.4 -1.6 -3.6
Lung FVC 1.6 8.3 19.1 -4.4 -2.3 1.9 -2.0 -2.5 -3.1 -3.4 -3.1 -3.0 2.2
Neuroticism 3.7 8.9 24.7 3.4 -4.0 -3.2 0.1 2.8 2.6 1.7 1.8 2.4 -5.0
Chronotype (morning person) 0.8 1.8 5.6 0.3 1.2 2.4 2.2 0.3 0.4 1.1 1.0 0.5 1.7
Hair Pigment 0.1 1.4 3.8 0.2 1.0 1.2 1.9 -0.5 -0.7 -0.9 -1.2 -1.4 -1.8
Tanning 0.1 1.0 6.4 0.2 -2.5 0.3 0.4 -1.2 -1.0 -0.4 0.7 0.4 -0.6
Hand grip strength (left) 0.5 1.4 5.1 -1.5 -2.2 1.2 -0.6 -1.3 -1.1 -1.2 -0.3 -0.6 -0.0
Number of treatments/medications taken 2.4 4.3 7.1 2.6 1.8 0.0 2.4 2.2 2.3 2.7 2.1 2.0 -0.8
Average weekly spirits intake 1.3 1.6 11.5 1.0 -0.4 -0.1 -0.6 -0.8 -1.1 -0.6 -0.3 -0.6 -3.4
Sensitivity / hurt feelings 0.7 1.3 3.1 0.9 -1.8 -1.1 -1.6 1.0 1.0 0.3 0.5 0.7 -1.4
Frequency of depressed mood in last 2 weeks 2.2 3.1 13.1 2.3 -1.7 -1.4 0.2 1.2 1.5 1.1 0.9 1.3 -3.6
Hearing difficulty/problems: Yes 1.3 1.9 4.5 -0.6 1.3 -0.3 -0.8 -1.2 -1.1 -1.6 -2.1 -1.8 -1.8
Relative age of first facial hair 2.0 4.1 12.7 1.8 -3.6 -1.4 0.9 1.7 1.9 1.8 2.4 2.6 0.2
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 2.5 1.6 0.5 0.2 0.2 1.2 1.0 1.5 1.3 0.8 0.0
Ever used hormone-replacement therapy (HRT) 2.3 2.9 5.9 2.4 -0.7 -1.2 1.2 1.8 2.2 1.9 1.6 2.0 -1.2
Ever had hysterectomy (womb removed) 1.1 1.3 3.7 1.5 0.8 -0.3 1.9 0.8 0.8 0.8 0.9 0.7 -1.7
Systolic blood pressure, automated reading 0.5 1.6 5.2 0.5 -2.3 -1.9 0.5 0.7 0.8 0.8 1.5 1.6 0.4
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 4.6 -1.1 1.0 2.1 -0.4 -1.4 -1.5 -1.0 -0.5 -0.6 0.2
Angina 2.6 3.5 8.5 -2.9 0.3 0.3 -1.9 -1.6 -1.7 -2.3 -2.6 -2.0 0.9
Medication for hormone replacement therapy 2.2 2.4 8.9 2.4 0.4 -1.1 0.4 1.1 1.7 1.4 0.8 1.1 -3.0
Vitamin and mineral supplements 0.5 0.6 3.3 -0.3 -1.8 -1.2 -0.1 0.1 -0.0 -0.0 0.5 0.7 0.8
Supplements: Zinc 3.3 3.6 6.4 -1.9 1.2 1.5 -2.5 -2.2 -2.0 -2.0 -2.3 -2.1 -0.2
Medication: Co-codamol 1.6 1.9 4.2 1.5 -0.2 0.3 1.5 1.6 1.9 2.0 1.4 1.4 -0.2
Medication: Metformin 0.9 1.2 3.6 1.1 1.9 1.1 1.6 0.5 0.7 0.9 0.6 0.5 -1.0
Diabetes (father) 0.6 0.7 1.6 -1.1 -0.2 0.6 -0.8 -1.3 -1.0 -1.0 -0.7 -0.7 0.5
Diabetes (mother) 1.8 2.3 5.1 2.3 -0.1 -0.5 1.7 1.1 1.6 1.8 2.1 2.0 -0.2
Severe depression (siblings) 0.5 0.5 1.3 0.5 -1.1 -0.7 0.2 0.8 0.8 0.7 0.8 0.9 -0.0
Pack years adult smoking proportion 1.0 1.5 9.0 1.3 2.0 0.5 0.3 -0.1 0.3 0.3 0.0 -0.3 -3.0
Impedance of leg (right) 0.5 2.3 5.5 1.0 -2.4 -1.0 -1.1 1.3 2.2 1.7 1.3 1.9 0.2
Leg fat-free mass (left) 0.7 3.5 9.1 -2.1 3.0 1.9 -0.1 -1.2 -1.6 -1.8 -2.1 -2.5 -0.3
Trunk fat percentage 0.6 2.5 5.5 2.4 2.2 0.1 0.4 1.4 1.9 2.1 1.5 1.2 -1.1
Hand grip strength (right) 0.4 1.0 4.0 -0.8 -1.5 2.0 1.1 -0.1 0.1 0.0 0.7 0.3 1.4
Townsend deprivation index at recruitment 1.6 2.2 10.5 2.5 0.2 -1.7 0.3 0.9 1.0 0.6 0.1 0.6 -3.2
Current tobacco smoking 1.3 2.2 12.5 2.4 -0.6 -0.4 -0.6 0.5 0.6 0.9 0.6 0.8 -3.5
Average weekly fortified wine intake 0.8 0.9 4.2 0.0 2.1 1.4 1.4 0.1 0.1 0.0 -0.3 -0.7 -0.4
Maternal smoking around birth 2.4 3.5 7.7 2.8 -0.8 -0.4 2.1 2.0 1.8 1.7 1.6 1.6 -2.7
Fed-up feelings 1.2 2.3 10.3 1.8 -1.5 -1.3 -1.5 0.2 0.7 0.6 0.5 1.3 -3.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.4 1.8 7.8 1.3 -1.6 -1.5 -1.8 0.2 0.2 0.0 -0.1 0.4 -2.8
Relative age voice broke 1.4 2.1 4.8 1.2 -2.2 0.5 1.2 1.6 1.6 1.5 1.7 1.6 0.5
Taking other prescription medications 2.5 3.8 7.9 2.8 0.7 0.5 2.4 1.9 2.2 2.6 2.2 2.1 -0.6
Age when periods started (menarche) 1.3 3.1 6.2 -2.4 -2.5 1.4 -2.1 -1.5 -1.4 -1.7 -1.3 -1.0 1.5
Bilateral oophorectomy (both ovaries removed) 5.9 6.8 12.5 3.5 -0.8 -2.6 1.9 3.2 3.0 2.9 2.9 2.8 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.4 8.1 -2.1 -2.0 2.8 -0.2 -2.0 -1.0 -1.1 -0.4 -0.3 1.1
Tinnitus: Yes, but not now, but have in the past 0.3 0.4 1.0 0.5 -0.2 1.0 0.9 0.1 0.3 0.5 0.9 0.7 0.3
Qualifications: CSEs or equivalent 1.3 1.7 4.9 1.6 1.9 1.4 2.2 0.8 0.9 1.1 0.8 0.5 0.2
Serious illness, injury or assault to yourself 0.0 0.0 0.1 0.3 0.3 0.3 -0.4 -0.1 -0.0 -0.1 -0.0 0.0 -0.2
High blood pressure 0.3 0.8 3.3 0.5 0.7 -1.8 1.1 1.0 0.7 0.7 0.4 0.6 -0.9
Hayfever, allergic rhinitis or eczema 4.4 9.6 16.1 3.9 -0.4 -1.7 3.6 3.1 3.2 3.8 3.8 4.0 0.5
Multivitamins +/- minerals 0.4 0.5 2.5 0.5 1.1 1.6 -0.3 0.3 0.4 0.4 -0.0 -0.3 -0.7
Stomach or abdominal pain in last month 1.4 1.8 5.1 2.0 1.7 0.7 2.3 1.2 0.7 1.1 0.9 0.3 -1.2
Supplements: Glucosamine 0.4 0.5 2.4 0.6 1.0 0.6 1.5 -0.0 0.6 0.3 -0.2 0.0 -0.2
Diverticular disease/diverticulitis (self-reported) 3.1 3.7 9.1 3.0 0.8 -1.1 1.2 2.8 2.1 2.0 1.5 1.8 -1.8
Medication: Atenolol 5.8 7.3 12.9 -3.6 2.4 2.2 -1.0 -3.0 -2.7 -3.0 -3.4 -3.3 0.7
Medication: Levothyroxine sodium 0.5 0.9 4.0 -0.6 0.9 -0.3 -0.4 -2.0 -1.6 -0.6 -0.4 -0.2 0.8
Sitting height 0.7 4.8 14.3 -3.8 0.9 3.3 0.1 -1.3 -1.6 -1.4 -1.6 -1.9 3.1
Chronic bronchitis/emphysema (father) 1.6 1.9 11.5 1.4 1.6 0.4 1.4 0.5 0.4 0.4 -0.5 -0.5 -3.4
High blood pressure (mother) 0.3 0.4 2.3 -0.0 1.5 -0.2 0.4 -0.2 -0.3 0.0 -0.2 -0.4 -0.9
Body mass index (BMI) 0.8 3.3 22.6 0.9 4.8 1.4 0.8 -0.4 -0.4 -0.2 -0.7 -1.4 -2.1
Impedance of leg (left) 0.6 3.1 6.4 1.4 -2.5 -1.1 -1.2 1.6 2.4 2.1 1.6 2.2 0.1
Leg predicted mass (left) 0.6 3.4 8.6 -2.0 2.9 1.9 -0.2 -1.2 -1.6 -1.8 -2.1 -2.5 -0.3
Trunk fat mass 0.4 1.7 8.0 1.4 2.8 0.7 0.3 0.9 1.2 1.3 0.6 0.2 -1.2
Waist circumference 0.7 2.6 13.3 1.1 3.6 0.3 0.0 0.5 -0.1 -0.1 -1.0 -1.2 -2.9
Number of incorrect matches in round 0.6 1.1 2.0 -1.2 -1.2 -0.2 -0.5 -1.0 -1.4 -1.1 -1.0 -1.1 1.0
Past tobacco smoking 1.1 2.1 10.4 -0.6 3.2 2.0 1.0 0.3 0.6 1.1 0.1 -0.4 1.8
Alcohol usually taken with meals 1.3 2.1 12.8 -0.6 0.8 1.3 1.3 1.2 1.1 1.0 0.7 0.4 3.6
Nervous feelings 1.1 2.1 4.8 1.2 -2.2 -1.6 0.2 1.8 1.5 1.1 1.3 1.3 -1.3
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 4.8 0.6 0.3 -0.9 -0.1 0.3 0.4 0.1 -0.1 0.0 -2.2
Hearing difficulty/problems with background noise 0.7 1.2 6.6 1.2 1.4 -0.3 0.5 0.4 0.3 -0.2 -0.9 -0.7 -2.6
Hair/balding pattern: Pattern 2 1.9 2.5 5.8 -1.1 0.8 1.6 -2.4 -1.9 -1.5 -1.4 -1.6 -1.5 -1.5
Had menopause 1.1 1.4 2.9 1.6 -1.7 -1.2 1.4 0.6 0.8 0.9 0.9 1.2 -0.9
Had other major operations 1.0 1.3 3.7 -0.9 1.9 1.1 1.4 -0.5 -0.9 -0.9 -0.9 -1.2 0.9
Forced vital capacity (FVC) 1.1 4.1 12.5 -3.2 -1.9 3.0 -0.0 -1.1 -1.3 -1.2 -0.7 -0.9 3.5
Heel bone mineral density (BMD) T-score, automated (right) 1.3 3.0 13.1 -2.5 -0.7 3.6 0.1 -2.1 -1.2 -1.2 -1.0 -1.1 0.8
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 1.1 0.9 -0.3 1.1 0.1 0.3 -0.0 0.0 0.2 0.1 -0.7
Qualifications: None of the above 0.5 1.0 3.2 1.3 -1.8 -0.8 -0.9 0.4 0.4 0.2 0.5 1.2 -1.5
Financial difficulties in last 2 years 0.3 0.4 1.1 0.5 0.8 0.9 -0.0 -1.1 -0.7 -0.3 -0.2 -0.5 -0.8
Mouth/teeth dental problems 3.4 5.3 13.8 1.7 -2.0 -3.7 -0.5 2.8 2.8 2.1 2.3 2.6 0.6
Heart attack 6.4 8.1 17.3 -4.2 -0.3 -0.1 -3.5 -3.0 -2.9 -3.3 -3.5 -3.0 1.6
Allergy 2.9 6.6 14.1 -3.8 0.5 1.7 -2.1 -2.5 -2.6 -3.2 -3.2 -3.3 0.2
Pain all over the body in last month 0.6 0.6 1.7 -0.8 -0.3 1.1 0.4 -1.1 -1.3 -0.7 -0.3 -0.6 0.6
Diabetes (self-reported) 0.8 1.2 2.3 1.5 0.6 0.2 1.4 0.7 0.9 1.2 1.5 1.2 -0.8
Hayfever/allergic rhinitis (self-reported) 1.5 2.0 3.7 1.5 0.4 -1.2 1.3 1.5 1.7 1.9 1.5 1.8 0.7
Medication: Ramipril 3.4 4.4 7.5 -2.2 2.5 1.2 -1.2 -2.7 -2.7 -2.1 -2.2 -2.4 0.2
Medication: Simvastatin 3.9 5.7 8.5 2.9 1.1 -2.9 1.8 2.7 2.8 2.8 2.3 2.6 -0.9
Fluid intelligence score 0.8 1.7 12.3 -0.4 3.5 1.4 1.0 0.5 0.1 0.1 -0.4 -0.5 0.4
Illnesses of siblings 1.2 1.6 3.4 -1.8 -0.9 1.1 -0.1 -1.1 -1.3 -1.7 -1.2 -1.2 1.5
Neuroticism score 3.0 6.3 21.1 2.8 -2.6 -2.4 -0.6 2.7 2.7 1.6 1.3 1.9 -4.6
Weight 0.5 2.5 13.1 -0.6 3.6 2.1 0.1 -0.6 -0.8 -0.7 -1.2 -1.8 -0.9
Impedance of arm (right) 3.5 16.3 27.8 4.4 -4.5 -3.6 0.6 4.2 4.5 4.6 4.7 5.3 0.2
Arm fat percentage (right) 1.1 4.2 11.0 3.3 3.1 -0.4 1.3 1.6 1.7 2.1 1.7 1.1 -2.2
Trunk fat-free mass 1.2 6.7 12.7 -3.4 2.6 2.6 -0.5 -2.1 -2.7 -2.9 -3.2 -3.6 -0.1
Hip circumference 0.6 2.4 14.4 0.2 3.8 1.9 0.9 -0.3 -0.5 -0.2 -0.6 -1.3 -1.5
Time employed in main current job 2.1 2.4 4.2 -2.0 -0.3 0.9 -1.7 -1.6 -1.8 -1.9 -1.9 -1.9 -0.5
Alcohol intake versus 10 years previously 0.5 0.7 1.8 0.1 1.1 -1.0 -0.7 -0.3 -0.6 -0.7 -0.9 -0.8 -1.3
Father’s age at death 0.8 1.1 2.3 0.8 -0.8 -1.1 0.0 0.8 1.3 1.3 1.5 1.5 0.6
Worrier / anxious feelings 0.8 1.5 6.2 0.6 -2.5 -1.2 -0.3 1.2 1.3 0.7 0.9 1.1 -1.0
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.5 3.0 1.5 -0.0 -0.9 0.1 1.7 1.7 1.4 0.9 1.4 -1.2
Falls in the last year 1.5 2.0 5.8 2.2 -0.3 -1.6 -0.4 1.3 1.2 1.0 0.8 1.1 -2.4
Hair/balding pattern: Pattern 3 2.1 3.1 7.6 0.7 0.3 -0.5 2.8 1.8 1.9 1.9 1.8 1.9 2.3
Number of live births 0.9 1.3 2.9 -1.3 -0.1 1.0 -1.0 -1.7 -1.5 -1.2 -0.8 -1.0 0.6
Forced expiratory volume in 1-second (FEV1) 0.7 2.3 6.7 -2.3 -0.9 2.6 0.3 -0.8 -1.0 -0.9 -0.5 -0.9 2.5
Pulse rate 5.1 8.6 17.9 -3.5 2.0 4.2 -2.3 -3.4 -2.9 -2.5 -2.6 -2.7 2.3
Happiness 0.5 0.7 4.2 0.5 -0.6 -0.8 -1.0 0.1 0.0 0.0 0.4 0.3 -2.1
Noisy workplace 1.5 1.9 7.9 1.0 2.8 0.1 1.4 0.2 0.2 0.0 -0.8 -0.7 -2.6
Qualifications: A levels/AS levels or equivalent 0.4 0.8 2.1 -1.2 1.0 0.5 0.3 0.3 -0.4 -0.8 -1.1 -1.4 -0.7
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 3.0 -0.9 -1.2 0.2 0.0 -0.1 -0.1 -0.0 0.3 -0.2 1.7
Mouth/teeth dental problems: Dentures 5.2 8.8 15.6 -2.9 1.9 4.0 -0.7 -3.9 -3.7 -3.0 -3.0 -3.5 -0.0
Asthma 4.1 8.1 16.7 4.1 -1.4 -1.6 1.3 2.9 3.5 3.6 3.3 3.4 -1.4
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.5 3.5 1.7 1.2 -0.7 1.5 0.8 0.7 1.2 1.2 0.7 -1.9
Medication: Cholesterol lowering 3.1 4.8 9.4 2.3 0.5 -2.6 0.3 2.6 3.1 2.7 2.1 2.6 -0.4
Depression (self-reported) 0.3 0.4 1.3 0.6 -0.3 -1.1 0.1 0.5 0.9 0.7 0.5 0.5 -0.7
Medication: Lansoprazole 0.5 0.6 1.6 0.6 0.3 -0.6 1.2 0.8 1.0 0.4 0.1 0.2 -1.3
Prospective memory result 0.7 0.9 3.8 -0.9 -2.0 -1.3 -1.1 -0.8 -0.5 -0.5 0.1 0.6 0.1
Lung cancer (father) 0.5 0.6 2.6 0.8 1.6 0.5 0.4 -0.5 -0.4 -0.4 -0.4 -0.6 -1.0
Illnesses of mother 0.3 0.4 1.2 -0.7 0.2 1.1 0.2 -0.6 -0.5 -0.6 -0.4 -0.5 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 3.7 9.4 -3.1 0.6 3.0 -0.1 -1.5 -1.7 -1.8 -1.7 -2.1 1.6
Pulse wave Arterial Stiffness index 0.6 0.7 2.1 0.8 -1.4 -0.9 -0.7 0.8 0.4 0.2 0.6 0.9 -0.8
Impedance of arm (left) 3.0 14.1 25.8 3.7 -4.3 -2.9 0.5 3.8 4.4 4.4 4.4 5.1 1.1
Arm fat mass (right) 0.5 1.9 11.2 1.5 3.4 0.8 0.8 0.5 0.5 0.7 0.2 -0.3 -1.7
Trunk predicted mass 1.2 6.6 12.5 -3.3 2.6 2.6 -0.4 -2.0 -2.6 -2.9 -3.1 -3.5 -0.1
Standing height 0.3 2.7 9.4 -3.1 -2.2 1.4 -1.4 -0.1 -0.6 -1.0 -1.2 -0.9 2.3
Length of working week for main job 0.3 0.3 0.8 0.2 0.7 -0.3 0.5 0.9 0.9 0.3 -0.1 -0.1 -0.5
Exposure to tobacco smoke at home 3.1 3.4 7.5 2.7 0.9 -0.9 1.2 2.2 2.2 2.1 1.5 1.5 -2.3
Breastfed as a baby 0.2 0.3 2.5 0.1 -1.6 -0.3 0.3 -0.2 -0.2 -0.3 0.1 0.2 0.3
Tense / ‘highly strung’ 0.4 0.7 2.6 0.6 -1.6 -0.6 0.0 1.0 0.9 0.4 0.2 0.7 -1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 2.6 1.6 1.1 0.5 1.3 1.0 1.1 1.1 0.7 0.5 -1.5
Hair/balding pattern: Pattern 4 0.3 0.6 4.5 0.5 0.0 -2.1 -0.4 0.0 -0.5 -0.6 -0.0 -0.2 -0.7
Birth weight of first child 1.2 2.1 3.7 1.8 -1.7 -1.9 0.7 1.7 1.3 1.4 1.4 1.5 -0.3
Peak expiratory flow (PEF) 1.2 2.7 5.5 1.0 -1.0 1.6 2.3 1.5 1.7 1.8 1.9 1.6 1.4
Pulse wave reflection index 4.9 6.1 11.5 3.4 -1.4 -3.4 0.4 3.0 2.3 1.6 2.0 2.5 -3.0
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.9 0.7 0.2 0.5 -0.0 0.3 0.4 0.6 0.9 0.8 -0.0
Loud music exposure frequency 0.6 0.7 3.2 0.9 -1.0 -1.8 -0.1 0.5 0.2 0.1 0.6 0.5 -0.9
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 2.2 -1.5 0.5 1.0 0.4 -0.5 -0.5 -0.6 -0.7 -0.9 1.3
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.7 -0.2 -0.2 0.8 -0.2 -0.4 -0.5 -0.3 -0.5 -0.3 -0.1
Blood clot in the leg (DVT) 0.2 0.2 0.7 -0.5 -0.7 -0.5 -0.8 -0.2 -0.5 -0.3 0.0 -0.1 0.6
Medication: Paracetamol 1.0 1.6 5.0 2.1 2.0 0.2 1.2 0.5 0.3 0.7 0.7 0.1 -2.2
Headache pain in last month 3.9 6.8 12.5 3.5 0.7 -0.3 3.3 3.1 2.8 2.7 2.8 2.4 -2.3
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.5 -0.4 -1.0 1.2 -0.1 -1.1 -1.2 -0.9 -0.5 -0.8 0.3
Glaucoma (self-reported) 0.9 1.1 3.8 -1.5 -0.3 1.5 0.3 -0.4 -0.8 -0.7 -0.7 -0.8 1.9
Gout (self-reported) 0.3 0.4 1.4 0.1 1.2 0.6 -0.4 -0.3 -0.4 -0.4 -0.7 -0.6 -0.6
Hypothyroidism/myxoedema (self-reported) 0.8 1.6 5.2 -1.0 1.1 0.2 -1.3 -2.3 -1.9 -1.0 -0.8 -0.8 0.9
Medication: Amlodipine 0.3 0.5 1.1 -0.2 0.8 0.1 0.0 -0.2 -0.8 -0.8 -0.9 -0.8 -1.1
Medication: Ventolin 100micrograms inhaler 0.9 1.2 2.8 1.7 -0.8 -0.3 0.1 1.4 1.1 1.1 1.2 1.2 -0.9
Birth weight 0.8 1.8 4.0 -0.9 0.5 -0.5 -1.1 -1.0 -1.2 -1.4 -2.0 -2.0 -1.9
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.9 1.2 1.4 0.2 0.9 0.3 -0.1 0.1 -0.2 -0.4 -1.4
High blood pressure (siblings) 1.7 2.4 4.3 2.1 0.6 -1.4 0.9 1.7 1.8 2.0 1.5 1.5 -1.5
Forced vital capacity (FVC), Best measure 1.8 6.5 18.4 -4.3 -0.5 3.4 -0.8 -2.2 -2.4 -2.5 -2.3 -2.6 2.3
Body fat percentage 0.6 2.5 9.3 2.2 3.0 0.5 0.4 1.0 1.5 1.7 1.0 0.6 -1.7
Leg fat percentage (right) 0.9 3.1 17.7 1.8 4.2 0.8 0.2 0.3 0.8 0.8 -0.1 -0.6 -2.8
Arm fat-free mass (right) 1.8 9.1 15.8 -3.7 3.7 3.2 -0.5 -2.6 -2.9 -3.1 -3.5 -4.0 0.0
Exposure to tobacco smoke outside home 1.0 1.4 5.3 1.8 2.3 0.0 0.8 0.7 0.8 1.2 0.4 0.4 -1.4
Comparative body size at age 10 0.7 1.9 7.5 0.2 1.6 0.7 2.7 0.9 1.2 1.5 1.3 0.7 1.3
Number of full brothers 1.3 1.6 4.4 2.1 -0.4 -0.6 -0.0 1.2 1.6 1.6 1.4 1.4 -0.6
Worry too long after embarrassment 1.3 2.2 7.8 1.3 -2.1 -2.6 -0.2 1.2 0.4 -0.3 -0.2 0.0 -2.8
Seen a psychiatrist for nerves, anxiety, tension or depression 1.3 1.7 5.9 1.4 1.4 0.9 2.4 1.1 1.2 1.0 0.9 0.8 -1.0
Wheeze or whistling in the chest in last year 2.1 3.8 9.9 3.1 0.1 -1.6 1.4 2.1 1.7 1.5 1.6 1.6 -3.1
Number of children fathered 0.4 0.5 1.1 -0.2 1.0 1.0 -0.1 -0.2 0.1 -0.3 -1.0 -1.0 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 3.2 0.5 0.0 -0.5 1.2 1.3 1.1 0.9 0.8 0.7 1.8
Age at first live birth 2.0 3.5 8.1 -2.8 0.6 1.2 -0.8 -1.7 -2.3 -2.3 -2.1 -2.3 1.3
Pulse wave peak to peak time 0.8 0.9 1.9 -1.2 1.4 1.1 0.5 -1.0 -0.6 -0.5 -0.9 -1.2 0.9
Health satisfaction 0.3 0.4 0.8 0.8 0.9 -0.2 -0.2 0.7 0.8 0.7 0.1 0.3 -0.7
Shortness of breath walking on level ground 1.9 2.2 3.7 1.9 -0.9 -1.7 -0.5 1.8 1.6 1.7 1.5 1.7 -1.0
Qualifications: College or University degree 0.1 0.4 1.6 -1.2 0.6 0.1 -0.6 0.4 0.3 -0.1 -0.0 -0.4 1.3
Eye problems/disorders: None of the above 1.3 1.5 3.8 1.3 -1.9 -0.9 0.8 0.8 1.4 1.1 1.2 1.6 0.0
Mouth/teeth dental problems: Loose teeth 1.3 1.5 2.3 -1.0 1.5 1.1 0.9 -1.5 -1.5 -1.3 -1.3 -1.3 -0.1
Emphysema/chronic bronchitis 1.6 1.8 4.3 -0.2 1.9 0.2 -0.7 -0.9 -1.4 -1.4 -1.6 -1.4 -2.1
Medication for pain relief, constipation, heartburn 1.4 2.4 5.3 -2.3 -1.1 0.8 -1.9 -1.4 -1.4 -1.4 -1.2 -0.9 2.2
Neck or shoulder pain in last month 0.9 1.3 5.1 0.9 1.3 0.7 1.8 0.4 1.0 0.7 0.0 0.0 -2.3
Medication: Blood pressure 1.1 2.0 5.6 -2.4 1.5 0.0 -1.0 -1.4 -1.3 -1.5 -1.8 -1.5 0.2
Angina (self-reported) 2.6 3.4 8.6 -2.9 0.4 0.6 -1.5 -1.8 -1.7 -2.2 -2.5 -2.0 1.1
Migraine (self-reported) 1.3 1.6 12.3 1.5 0.2 -0.8 -0.4 0.7 0.3 0.1 -0.1 0.0 -3.5
Medication: Ibuprofen 1.3 1.6 2.9 1.7 0.8 -0.4 1.3 1.1 1.1 1.4 1.5 1.1 -1.6
Medication: Allopurinol 0.2 0.3 1.2 -0.3 1.1 0.4 -0.1 -0.4 -0.6 -0.3 -0.6 -0.5 0.4
Medication: Omeprazole 0.2 0.3 0.9 -0.2 -0.0 -0.9 -1.0 0.6 0.2 -0.3 -0.4 -0.3 -0.3
Medication: Seretide 50 evohaler 1.8 2.1 4.2 1.9 -0.6 -0.6 2.1 1.7 1.5 1.6 1.4 1.5 -0.7
Mean time to correctly identify matches 1.3 2.5 4.3 -2.0 -0.6 1.3 -1.4 -1.4 -1.9 -1.9 -1.8 -2.1 0.7
Heart disease (mother) 0.5 0.6 1.8 -1.1 1.4 0.9 -0.3 -0.4 -0.2 -0.0 -0.4 -0.5 1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 3.3 1.2 -1.2 -0.5 1.0 0.6 1.0 1.0 1.8 1.8 -0.4
Whole body fat mass 0.4 1.8 10.7 1.2 3.3 1.1 0.5 0.5 0.8 0.9 0.3 -0.2 -1.4
Leg fat mass (right) 0.9 3.5 21.9 0.5 4.7 1.8 0.2 -0.5 -0.3 -0.2 -1.0 -1.6 -2.4
Arm predicted mass (right) 2.0 10.3 18.0 -4.0 3.5 3.6 -0.3 -2.8 -3.1 -3.4 -3.8 -4.2 0.1
Pulse rate, automated reading 1.0 3.1 6.2 -1.8 2.5 2.3 -1.9 -2.0 -1.4 -0.9 -1.4 -1.5 1.2
Alcohol intake frequency. 0.8 1.9 13.2 1.0 3.6 1.3 1.1 -0.5 -0.0 0.7 0.3 -0.3 -0.9
Comparative height size at age 10 0.1 0.5 1.0 -1.0 1.0 0.9 0.1 0.4 0.1 -0.1 -1.0 -0.7 -0.5
Number of full sisters 1.8 2.2 14.8 0.8 -0.1 -0.5 -1.0 -1.2 -0.9 -1.0 -1.3 -0.8 -3.9
Suffer from ‘nerves’ 1.8 2.8 5.8 2.3 -0.1 -0.9 1.1 2.2 2.0 1.6 1.4 1.1 -2.4
Overall health rating 0.7 1.4 7.7 1.1 1.8 0.1 0.4 0.8 0.7 0.6 -0.4 -0.2 -2.8
Chest pain or discomfort 1.3 1.8 3.3 -0.8 0.2 0.8 -0.5 -1.5 -1.8 -1.7 -1.7 -1.6 -1.6
Had major operations 0.3 0.3 0.8 0.9 0.5 -0.2 0.4 0.9 0.6 0.6 0.5 0.3 0.4
Age at last live birth 1.0 1.5 4.3 -2.1 0.5 0.6 -1.1 -1.0 -1.0 -1.3 -1.5 -1.4 0.9
Family relationship satisfaction 1.7 2.1 4.5 -0.7 -0.8 0.2 -2.1 -1.7 -1.9 -1.6 -1.2 -1.1 -1.8
Leg pain on walking 0.6 0.8 1.6 0.7 -1.0 -0.8 -0.3 0.8 0.7 0.9 1.0 1.3 1.1
Qualifications: NVQ or HND or HNC or equivalent 2.0 2.4 4.8 2.2 -2.2 -1.4 0.7 1.2 1.1 1.5 2.0 1.7 -0.3
Commuting to job workplace: Car/motor vehicle 1.1 1.3 6.8 -1.1 1.4 2.6 0.4 -0.4 -0.4 -0.5 -1.0 -0.9 0.5
Illness, injury, bereavement, stress in last 2 years 1.5 1.8 3.9 0.6 -0.7 -2.0 -0.0 1.8 1.9 1.4 1.2 1.8 0.1
Medication: Aspirin 0.2 0.2 0.8 -0.8 -0.1 -0.6 -0.1 -0.1 -0.2 -0.4 -0.4 -0.1 0.9
Supplements: Vitamin C 0.7 0.9 1.7 -0.8 1.3 0.7 0.6 -1.0 -1.2 -0.9 -0.8 -1.1 0.3
Knee pain experienced in last month 3.3 5.1 13.9 2.9 -0.3 -3.7 -0.8 2.0 2.1 2.0 1.6 1.9 -3.1
Hypertension (Self-reported) 0.3 0.7 2.7 0.2 1.0 -1.7 1.2 0.9 0.6 0.5 0.1 0.3 -0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 2.3 0.6 1.4 -0.4 0.8 0.6 0.5 0.0 -0.3 -0.4 -1.5
Illnesses of father: Heart disease 1.8 2.5 6.5 -2.4 2.6 1.2 -0.3 -1.0 -0.6 -0.9 -1.3 -1.0 2.5
Illnesses of siblings: Diabetes 0.8 1.0 2.1 -0.7 1.2 0.8 -0.7 -1.4 -1.5 -1.0 -0.9 -0.8 -0.2
Smoking status: Previous 0.6 0.9 5.0 -0.2 -2.2 -1.6 -0.4 -0.1 -0.5 -1.0 -0.2 0.2 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 3.5 -1.9 0.6 0.6 -0.9 -0.1 -0.4 -0.9 -1.2 -1.1 1.0
Whole body fat-free mass 1.1 6.2 11.5 -3.0 2.9 2.5 -0.5 -2.0 -2.5 -2.7 -3.0 -3.4 -0.2
Leg fat-free mass (right) 0.6 3.0 7.1 -1.9 2.7 1.9 -0.2 -1.2 -1.6 -1.6 -1.9 -2.3 -0.0
Arm fat percentage (left) 1.0 3.9 10.8 3.1 3.3 0.1 1.4 1.5 1.8 2.1 1.6 1.0 -1.9
Average weekly red wine intake 0.9 1.3 4.9 -0.0 -1.3 -0.6 -0.5 1.5 1.4 0.6 0.4 0.9 2.2
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.3 -0.8 0.9 -0.9 -0.2 -0.8 -1.1 -0.8 -0.8 -0.9 -0.3
Mood swings 2.7 4.9 9.2 2.7 -0.8 -2.1 0.2 2.7 2.8 2.2 1.6 2.2 -3.0
Loneliness, isolation 1.5 2.0 12.2 1.9 -0.6 -0.9 -0.1 1.1 1.1 0.6 0.3 0.4 -3.5
Long-standing illness, disability or infirmity 0.8 1.2 3.8 1.9 1.2 -0.2 -0.1 0.7 0.7 1.1 0.6 0.4 -1.9
Ever had bowel cancer screening 3.0 3.6 9.4 1.8 -1.6 0.3 3.1 2.5 1.4 1.6 2.5 1.9 0.4
Diabetes diagnosed by doctor 0.4 0.7 1.4 1.0 1.2 0.4 1.2 -0.1 0.2 0.7 1.2 0.8 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 1.6 1.7 3.7 -0.7 0.2 0.9 -1.1 -1.1 -1.5 -1.5 -1.8 -1.9 -1.3
Friendships satisfaction 0.5 0.6 2.9 -0.1 -1.7 -0.6 -1.1 -0.3 -0.3 -0.1 0.4 0.5 -1.1
Qualifications: nursing, teaching 0.3 0.5 1.7 -0.9 1.3 1.0 -0.1 -0.7 -0.5 -0.6 -0.4 -0.7 0.2
Commuting to job workplace: Walk 1.4 1.5 2.9 1.7 -1.1 -1.5 0.6 0.9 0.9 1.2 1.5 1.6 0.2
Eye problems/disorders: Cataract 0.4 0.5 1.6 -0.4 0.5 -1.2 -0.6 -0.0 -0.7 -0.8 -0.7 -0.9 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 2.0 0.4 0.4 0.8 1.3 0.2 -0.2 0.1 0.4 0.1 -1.4
Medication for cholesterol 2.9 4.4 7.1 -2.7 -1.1 2.2 -1.6 -2.4 -2.3 -2.4 -1.8 -2.0 2.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.5 2.4 0.8 -1.5 0.3 0.0 0.8 0.4 0.2 0.6 0.5 -0.8
Back pain experienced in last month 0.4 0.7 3.9 0.2 0.8 0.8 0.9 -0.2 -0.2 -0.1 -0.3 -0.6 -2.0
Mineral and other dietary supplements 0.9 1.2 2.2 -1.4 -0.9 -0.9 -1.5 -1.2 -1.5 -1.2 -0.6 -0.8 0.6
Breast cancer (self-reported) 0.4 0.5 2.6 -0.6 -0.9 -1.6 0.3 0.3 -0.1 -0.7 -0.6 0.1 0.4
Asthma (self-reported) 3.9 7.8 16.5 4.1 -1.3 -1.6 1.3 2.8 3.4 3.5 3.3 3.4 -1.3
Osteoporosis (self-reported) 0.8 1.0 4.0 -0.2 2.0 0.3 -0.3 -0.1 -0.3 -1.0 -1.4 -1.2 -1.4
Osteoarthritis (self-reported) 0.8 1.1 4.9 1.6 1.0 -1.3 -0.5 -0.3 -0.3 0.1 -0.1 -0.3 -2.2
Medication: Aspirin 0.2 0.3 0.9 -0.9 -0.2 -0.5 0.0 -0.4 -0.5 -0.6 -0.4 -0.2 0.9
Medication: Gliclazide 0.2 0.3 1.5 0.4 -0.5 -1.2 0.3 -0.0 0.1 -0.1 0.3 0.5 -0.6
Illnesses of father: None of the above (group 1) 0.3 0.3 2.1 -0.3 -1.4 -0.4 -0.7 -0.2 -0.1 -0.1 0.2 0.1 0.6
Smoking status: Current 1.3 2.1 11.8 2.3 -0.6 -0.7 -1.0 0.4 0.6 0.8 0.5 0.7 -3.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 4.2 -0.5 0.5 2.1 0.4 -0.5 -0.5 -0.5 -0.4 -0.7 0.3
Whole body water mass 1.1 6.2 11.6 -3.1 2.8 2.4 -0.5 -2.1 -2.6 -2.7 -3.0 -3.4 -0.1
Leg predicted mass (right) 0.6 3.0 6.9 -1.9 2.6 1.9 -0.2 -1.2 -1.6 -1.6 -1.9 -2.3 0.0
Arm fat mass (left) 0.5 1.9 12.1 1.3 3.5 0.9 0.9 0.3 0.3 0.6 0.2 -0.4 -1.5
Number of self-reported non-cancer illnesses 3.7 6.4 12.5 3.5 1.7 -1.7 2.5 3.0 2.8 2.7 1.9 2.0 -2.8
Average weekly champagne plus white wine intake 0.7 1.0 3.0 1.2 0.9 -0.9 1.7 0.9 0.6 1.0 0.9 0.8 0.7
Miserableness 3.6 6.2 14.8 3.1 -2.1 -2.3 0.5 2.3 2.7 2.0 2.1 2.6 -3.8
Guilty feelings 1.8 2.7 21.2 1.6 -0.5 -1.0 -0.8 0.6 0.3 -0.3 -0.8 -0.4 -4.6
Wears glasses or contact lenses 0.6 0.6 1.2 -0.4 -0.4 0.3 -1.0 -1.1 -1.1 -1.1 -0.8 -0.8 0.4
Ever taken oral contraceptive pill 2.5 2.8 5.5 -1.9 0.4 -0.2 -2.4 -1.4 -1.4 -1.9 -2.2 -2.1 -1.2
Hearing aid user 0.5 0.6 2.5 0.1 -1.1 -1.6 -1.2 -0.4 -0.6 -0.4 0.0 0.0 -0.1
Mother’s age at death 1.1 1.3 2.6 1.0 -1.4 -1.1 0.4 1.2 0.6 1.2 1.6 1.5 1.0
Financial situation satisfaction 0.7 0.9 3.5 -0.1 0.2 -0.6 -0.5 -0.5 -0.9 -1.1 -1.2 -1.2 -1.9
Tinnitus: Yes, now most or all of the time 0.6 0.7 2.5 0.6 -0.8 -1.6 -1.1 0.8 0.8 0.6 0.3 0.7 -0.1
Commuting to job workplace: Public transport 0.4 0.5 1.6 0.8 0.0 -0.9 -0.2 1.3 0.7 0.5 0.5 0.6 -0.0
Eye problems/disorders: Glaucoma 0.6 0.7 1.6 -1.2 -0.1 1.0 -0.9 -0.4 -0.8 -0.6 -0.8 -0.9 1.1
Medication: Blood pressure 0.5 1.0 1.6 0.6 -0.4 -1.1 1.2 1.3 0.6 1.1 1.3 1.2 1.0
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.8 -0.1 0.4 1.4 1.1 -0.1 0.4 0.4 0.2 0.4 1.2
Supplements: Fish oil (including cod liver oil) 0.5 0.6 2.0 0.5 -0.6 1.0 1.4 0.6 0.7 0.6 0.6 0.6 0.9
High cholesterol (Self-reported) 9.4 16.7 30.5 5.5 2.4 -3.9 3.9 4.9 4.9 4.3 3.3 3.5 -3.4
Medication: Bendroflumethiazide 0.1 0.2 0.6 -0.0 0.2 -0.8 0.5 0.5 0.1 0.3 0.2 0.3 0.6
Medication: Paracetamol 0.6 0.9 3.4 0.6 1.8 0.8 0.4 -0.4 -0.7 -0.4 -0.4 -0.8 -1.8
Medication: Lisinopril 1.0 1.3 6.2 -0.6 -1.8 -0.8 -0.5 0.5 0.4 0.4 1.0 1.0 2.5
Medication: Atorvastatin 2.2 2.8 6.1 2.5 0.4 -1.6 0.5 1.9 2.2 1.9 1.2 1.7 -1.4
Illnesses of father: High blood pressure 0.8 1.0 2.4 1.5 -0.7 -0.8 0.7 0.7 0.7 0.8 1.1 1.2 -1.1
Alcohol drinker status: Never 1.8 2.1 10.4 -0.1 3.2 2.2 2.2 -0.0 0.3 0.5 -0.2 -0.8 -0.6
Ever smoked 1.8 3.2 11.7 1.5 -3.4 -3.0 -1.1 0.5 0.5 -0.2 0.7 1.2 -2.3
Basal metabolic rate 0.9 5.2 10.4 -2.6 3.2 2.5 -0.4 -1.7 -2.1 -2.2 -2.6 -3.1 -0.2
Leg fat percentage (left) 0.9 3.4 17.0 2.3 4.1 0.7 0.3 0.6 1.1 1.2 0.3 -0.3 -2.9
Arm fat-free mass (left) 1.4 7.3 14.0 -3.2 3.0 2.4 -0.8 -2.4 -2.8 -3.0 -3.3 -3.7 -0.4
Number of operations (self-reported) 0.6 0.9 5.2 0.4 1.3 -0.1 2.3 0.8 0.5 0.3 0.4 0.2 0.8
Average weekly beer plus cider intake 3.7 5.4 12.9 -1.4 2.0 -0.6 -2.0 -1.5 -1.8 -2.5 -3.2 -2.9 -3.6
Irritability 2.0 3.4 8.4 1.9 -2.7 -2.4 -0.6 1.7 1.6 0.9 0.8 1.2 -2.9
Risk taking 1.6 2.3 6.9 2.2 -1.1 -1.2 1.5 1.5 1.0 0.8 0.9 1.5 -2.6
Ever had prostate specific antigen (PSA) test 0.3 0.3 1.2 0.1 -1.1 -0.8 -0.3 0.3 0.2 -0.2 -0.1 0.1 -1.1
Fractured/broken bones in last 5 years 1.1 1.5 3.0 -0.2 1.4 -0.6 -1.3 -0.3 -1.0 -1.3 -1.7 -1.6 -1.6
Age started oral contraceptive pill 0.5 0.7 4.0 -1.1 -0.3 -0.5 -0.3 -0.3 -0.3 -0.5 -0.6 -0.1 2.0
Diastolic blood pressure, automated reading 2.5 7.9 16.1 4.0 -0.5 -2.0 2.1 2.6 2.8 2.9 3.0 2.8 -3.8
Ever depressed for a whole week 1.0 1.2 6.2 1.1 1.1 1.0 1.4 0.1 -0.4 0.1 0.1 -0.5 -2.5
Unable to work because of sickness or disability 0.3 0.4 1.8 -0.3 1.1 1.3 0.2 -0.5 -0.0 0.4 -0.1 0.1 0.1
Commuting to job workplace: Cycle 1.0 1.3 6.4 1.1 -2.5 -1.4 -0.2 1.0 0.7 0.5 0.7 1.0 0.3
Myopia 0.2 0.3 1.0 -0.4 -0.5 0.7 1.0 -0.2 -0.5 -0.4 0.3 0.1 0.7
Vascular/heart problems diagnosed by doctor 0.2 0.4 2.7 0.4 -1.0 1.6 -0.0 -0.4 -0.3 -0.1 0.5 0.1 0.4
Cholesterol lowering medication 6.8 10.0 19.6 4.4 1.9 -2.9 3.5 3.5 3.2 3.3 2.6 2.5 -3.1
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 1.8 0.9 0.4 -1.1 0.2 1.4 1.2 0.8 0.6 0.6 -0.0
Pain experienced in last month 2.6 4.3 6.4 -2.5 0.2 0.3 -1.8 -2.3 -2.5 -2.5 -2.1 -2.1 2.4
Supplements: Calcium 1.0 1.1 3.0 1.2 1.5 -1.4 0.3 1.2 0.6 0.4 -0.5 0.2 -1.7
Basal cell carcinoma (self-reported) 0.9 1.0 2.2 0.8 0.0 0.6 0.7 1.1 1.4 1.3 1.5 1.1 0.6
Heart attack/myocardial infarction (self-reported) 5.6 7.3 15.8 -4.0 -0.2 -0.1 -3.2 -2.9 -2.7 -3.1 -3.2 -2.7 1.8
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.3 -0.5 -1.1 -0.6 -1.0 -0.1 -0.5 -0.2 0.3 0.2 0.8
Heart disease (siblings) 0.5 0.6 1.7 -0.7 0.9 1.1 -1.3 -0.5 -0.1 -0.0 -0.4 -0.4 1.2
Alcohol drinker status: Previous 0.8 0.9 3.3 1.2 0.7 -0.3 1.4 0.1 0.4 0.7 0.8 0.6 -1.8
Pack years of smoking 0.9 1.3 7.4 1.0 1.9 0.5 0.1 -0.2 0.0 0.0 -0.2 -0.5 -2.7
Impedance of whole body 1.7 8.7 15.5 2.8 -3.7 -2.2 -0.2 3.0 3.7 3.5 3.2 3.9 0.8
Leg fat mass (left) 0.8 3.2 20.5 0.9 4.5 1.7 0.4 -0.2 0.0 0.2 -0.7 -1.2 -2.3
Arm predicted mass (left) 1.4 6.9 13.0 -3.0 3.2 2.4 -0.6 -2.3 -2.8 -2.8 -3.1 -3.6 -0.4