Hub : Genes

WDR12

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Colon Adenocarcinoma	0.0820	0.0420	0.0013	0.038	0.004	-0.002	NA	0.011	0.0030	0.1700	0.440	NA	0.0700
2	TCGA	Lung Adenocarcinoma	0.0394	0.0261	0.0037	0.019	0.015	0.001	NA	0.021	0.0025	0.0064	0.230	NA	0.0014
3	TCGA	Lung Squamous Cell Carcinoma	0.0380	0.0212	0.0015	0.003	0.022	0.007	NA	0.006	0.1400	0.0012	0.042	NA	0.0580

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.0	1.6	2.4	1.5	0.8	1.3
Bipolar Disorder or Schizophrenia	0.5	1.3	2.7	0.3	1.6	-1.1
Depressed Affect (Nagel 2018)	5.8	12.2	21.8	-4.7	-2.1	-3.2
Depression (Nagel 2018)	1.9	2.9	5.7	-2.4	-1.7	-0.4
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.1	1.0	-0.4	0.3
Neuroticism (Nagel 2018)	2.8	6.7	12.0	-3.5	-1.1	-2.6
Schizophrenia (2018)	1.5	3.1	6.3	-0.9	1.4	-2.5
Schizophrenia vs Biploar Disorder	5.4	7.1	10.8	-3.3	-0.8	-3.1
Worry (Nagel 2018)	0.7	1.5	2.2	-1.3	0.7	-1.5
Alzheimer’s Disease (in mother)	0.9	1.0	1.7	-1.3	-1.1	-0.2
Alzheimer’s Disease (in father)	9.8	10.6	15.7	-3.6	-4.0	-1.7
Alzheimer’s Disease (including proxy)	7.5	10.9	15.4	-3.9	-3.9	-1.4
Crohns Disease (2017)	1.5	3.4	5.2	2.2	0.6	2.3
Irritable Bowel Disease (IBD)	0.3	0.8	1.1	1.1	0.4	1.0
Ulcerative Colitis (UC)	0.1	0.1	0.2	-0.5	-0.3	-0.3
Major Depression (MDD)	0.8	1.0	1.3	-1.0	-1.2	-0.8
Reaction Time	1.0	1.9	2.8	1.7	1.5	0.7
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.4	1.2	-0.5	0.5
Breast Cancer	0.8	1.9	2.9	1.7	1.6	-0.3
Ovarian Cancer	3.2	4.3	7.5	2.7	1.9	1.3
Prostate Cancer	0.4	0.6	1.1	-1.1	-0.3	-0.8
Age at First Birth	2.4	3.5	7.0	1.8	2.6	0.2
Bipolar Disorder (2011)	2.3	2.2	4.2	2.0	0.7	1.4
Body Mass Index (BMI) (2010)	3.7	5.1	9.1	-2.4	-3.0	-0.8
Coronary Artery Disease (CAD)	22.4	26.7	43.5	6.6	5.2	3.2
Crohns Disease (2012)	0.4	0.6	0.9	0.9	0.1	1.0
Mean Putamen Volume	0.9	1.0	2.2	-0.7	-1.5	0.6
Fasting Glucose	1.3	1.6	2.3	-1.5	-1.5	0.5
HbA1C	0.5	0.5	1.0	0.0	-0.8	1.0
HDL Cholesterol	0.1	0.2	0.5	-0.7	-0.2	-0.4
LDL Cholesterol	5.6	8.8	15.8	-3.1	-4.0	1.1
Lupus	1.4	2.2	5.5	-0.9	-0.3	-2.4
Neuroticism (2016)	3.1	4.5	7.3	-2.7	-1.3	-2.1
Primary Biliary Cirrhosis	1.0	1.4	2.7	-1.3	-0.2	-1.6
Rheumatoid Arthritis	0.8	1.1	1.7	-1.1	-1.3	-0.6
Schizophrenia (2014)	1.7	3.8	7.3	-0.6	1.9	-2.7
Triglycerides	2.0	3.2	6.1	-1.9	-2.5	0.0
Type 2 Diabetes (T2D) (2012)	4.1	4.8	5.9	-2.4	-1.6	-2.4
Ulcerative Colitis	0.2	0.2	0.7	-0.2	-0.8	0.0
Blood Eosinophil Count	1.9	14.4	20.0	-4.5	-4.4	-1.9
Blood Platelet Count	1.7	20.1	47.6	-3.6	-6.9	-0.1
Blood Red Count	0.4	3.8	8.0	2.8	1.5	1.0
Blood White Count	0.9	6.9	11.4	-3.0	-3.4	0.2
Heel T-Score	2.1	16.5	31.0	1.7	5.6	-3.9
BMI	2.0	11.3	18.1	-3.5	-4.2	-2.0
Height	1.0	19.2	30.6	5.5	3.9	3.5
Waist Hip Ratio (WHR)	0.3	1.5	2.3	-1.5	-1.4	0.2
Systolic Blood Pressure	2.5	12.4	18.1	3.5	4.2	2.6
Smoking Status	4.9	11.8	18.9	-4.3	-4.0	0.5
Allergy or Eczema	2.6	6.8	11.8	-2.6	-1.3	-3.4
Cardiovascular Disease	1.0	3.3	7.0	-1.1	-2.6	1.3
Hypothyroidism (self reported)	0.0	0.1	0.2	0.1	-0.2	0.4
Respiratory disease	8.8	19.7	27.5	-5.0	-5.2	-2.5
Type 2 Diabetes (T2D) (2018)	1.8	3.4	4.4	-2.1	-1.3	-2.0
Lung FEV1/FVC ratio	2.4	12.0	21.4	-3.7	-4.6	-0.9
Lung FVC	2.8	14.3	23.1	4.2	4.8	1.3
Neuroticism	3.7	8.9	18.9	-4.3	-1.3	-2.5
Chronotype (morning person)	0.3	0.6	0.8	0.8	0.6	-0.9
Hair Pigment	0.0	0.7	1.5	-0.7	-1.2	-0.3
Tanning	0.1	1.5	2.7	-1.6	-1.4	0.3
Hand grip strength (left)	0.1	0.4	0.6	0.4	0.8	0.6
Number of treatments/medications taken	1.9	3.5	6.5	-1.9	-2.6	-0.6
Average weekly spirits intake	6.0	7.4	13.2	-3.6	-2.6	-1.6
Sensitivity / hurt feelings	0.8	1.3	3.2	-1.8	-0.6	-0.6
Frequency of depressed mood in last 2 weeks	5.1	7.1	13.4	-3.7	-2.3	-1.7
Hearing difficulty/problems: Yes	0.4	0.6	1.7	-0.5	-1.3	0.2
Relative age of first facial hair	1.5	3.0	4.7	-0.9	1.9	-2.2
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	2.2	-1.3	-1.5	-0.5
Ever used hormone-replacement therapy (HRT)	3.0	3.8	5.9	-2.4	-2.0	-1.2
Ever had hysterectomy (womb removed)	2.0	2.3	4.2	-1.6	-2.0	-0.4
Systolic blood pressure, automated reading	0.9	2.5	3.1	1.3	1.6	1.8
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.4	-0.6	-0.2	-0.7
Angina	7.0	9.2	12.7	3.6	1.8	3.4
Medication for hormone replacement therapy	7.7	8.6	12.7	-3.4	-3.6	-1.1
Vitamin and mineral supplements	1.6	2.1	5.0	1.1	2.2	0.2
Supplements: Zinc	0.1	0.1	0.3	0.3	-0.1	0.6
Medication: Co-codamol	0.2	0.2	0.3	-0.5	-0.5	-0.3
Medication: Metformin	2.4	3.4	3.8	-1.9	-1.9	-1.6
Diabetes (father)	0.7	0.9	1.4	0.9	1.2	0.7
Diabetes (mother)	2.3	3.0	4.6	-2.0	-0.4	-2.1
Severe depression (siblings)	0.5	0.5	1.5	0.2	-0.3	1.2
Pack years adult smoking proportion	4.5	6.9	9.4	-3.1	-2.6	-2.1
Impedance of leg (right)	0.0	0.2	0.6	-0.1	-0.0	0.8
Leg fat-free mass (left)	0.1	0.6	1.0	1.0	-0.2	0.9
Trunk fat percentage	1.6	6.3	11.2	-2.7	-3.3	-0.6
Hand grip strength (right)	0.3	0.9	1.9	0.8	1.4	0.1
Townsend deprivation index at recruitment	7.6	10.6	15.9	-4.0	-3.7	-1.6
Current tobacco smoking	9.1	14.8	23.0	-4.8	-4.4	-1.5
Average weekly fortified wine intake	0.3	0.4	0.8	0.3	-0.5	-0.9
Maternal smoking around birth	3.4	5.0	8.4	-2.9	-1.9	-1.7
Fed-up feelings	3.8	6.9	13.2	-3.6	-1.8	-2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	3.6	4.8	7.9	-2.5	-2.8	0.7
Relative age voice broke	1.1	1.7	3.0	-0.5	1.3	-1.7
Taking other prescription medications	4.6	7.2	9.4	-2.9	-1.9	-3.1
Age when periods started (menarche)	2.4	5.8	10.7	2.5	3.3	0.7
Bilateral oophorectomy (both ovaries removed)	2.6	3.0	4.7	-2.2	-1.7	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.4	7.8	1.2	2.8	-1.1
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	2.0	-0.6	0.4	-1.4
Qualifications: CSEs or equivalent	3.3	4.3	8.9	-1.8	-0.9	-3.0
Serious illness, injury or assault to yourself	0.4	0.5	0.8	-0.8	-0.9	-0.3
High blood pressure	0.8	2.3	5.7	0.9	-0.6	2.4
Hayfever, allergic rhinitis or eczema	2.8	6.2	12.4	-2.4	-0.7	-3.5
Multivitamins +/- minerals	1.7	2.2	2.7	-1.4	-1.6	-1.3
Stomach or abdominal pain in last month	5.5	6.9	8.3	-2.9	-2.8	-2.1
Supplements: Glucosamine	0.8	1.1	1.1	-1.0	-1.0	-1.1
Diverticular disease/diverticulitis (self-reported)	8.7	10.3	18.1	-3.5	-4.3	-0.9
Medication: Atenolol	5.9	7.4	12.2	3.5	1.8	2.6
Medication: Levothyroxine sodium	0.0	0.0	0.1	0.3	0.1	0.1
Sitting height	2.3	16.6	28.5	5.3	3.6	2.9
Chronic bronchitis/emphysema (father)	4.9	5.8	7.0	-2.6	-2.5	-2.0
High blood pressure (mother)	0.3	0.4	1.0	0.4	0.2	1.0
Body mass index (BMI)	1.8	7.5	12.6	-2.8	-3.5	-1.4
Impedance of leg (left)	0.0	0.2	0.3	-0.5	-0.3	0.4
Leg predicted mass (left)	0.1	0.6	0.9	1.0	-0.2	0.9
Trunk fat mass	1.1	4.5	9.2	-2.1	-3.0	-0.3
Waist circumference	2.2	7.9	14.0	-3.0	-3.7	-0.9
Number of incorrect matches in round	1.7	2.8	6.1	1.5	2.5	-0.2
Past tobacco smoking	1.3	2.4	5.6	2.4	1.3	-0.1
Alcohol usually taken with meals	2.5	4.1	9.0	3.0	1.6	0.9
Nervous feelings	0.7	1.3	1.8	-0.6	1.3	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.6	-1.1	-1.3	0.4
Hearing difficulty/problems with background noise	3.2	5.2	8.2	-2.4	-2.9	-1.3
Hair/balding pattern: Pattern 2	1.0	1.2	2.2	-0.6	-1.5	1.0
Had menopause	0.8	0.9	1.4	-1.2	-1.2	-0.2
Had other major operations	0.4	0.5	1.1	1.1	0.4	0.2
Forced vital capacity (FVC)	3.4	13.2	23.1	4.0	4.8	0.9
Heel bone mineral density (BMD) T-score, automated (right)	2.0	4.6	9.3	1.6	3.0	-1.4
Ever unenthusiastic/disinterested for a whole week	2.1	2.6	4.0	-2.0	-1.4	-1.4
Qualifications: None of the above	1.3	2.7	5.5	-2.3	-1.6	-0.5
Financial difficulties in last 2 years	2.3	3.0	4.1	-2.0	-1.0	-2.0
Mouth/teeth dental problems	1.5	2.3	6.4	0.7	-0.4	2.5
Heart attack	12.6	16.1	21.9	4.7	3.2	4.0
Allergy	3.3	7.5	10.1	3.2	2.5	2.5
Pain all over the body in last month	0.6	0.6	1.3	0.7	-0.1	1.1
Diabetes (self-reported)	1.6	2.4	3.8	-1.7	-0.8	-1.9
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.9	-0.1	0.3	-0.9
Medication: Ramipril	1.7	2.2	3.8	1.6	-0.0	2.0
Medication: Simvastatin	2.9	4.2	8.2	-1.1	-2.9	1.8
Fluid intelligence score	0.3	0.6	1.3	0.5	-1.1	0.6
Illnesses of siblings	1.0	1.4	2.1	1.5	0.2	1.4
Neuroticism score	3.4	7.0	14.0	-3.7	-1.3	-2.3
Weight	0.2	1.1	2.8	-0.6	-1.7	-0.1
Impedance of arm (right)	0.4	1.9	4.4	-2.1	-1.2	-0.2
Arm fat percentage (right)	3.5	13.8	21.3	-4.2	-4.6	-1.5
Trunk fat-free mass	0.3	2.0	4.0	2.0	0.9	1.1
Hip circumference	1.0	4.2	8.2	-1.9	-2.9	-0.8
Time employed in main current job	0.9	1.0	1.4	1.2	0.9	0.9
Alcohol intake versus 10 years previously	1.1	1.7	3.3	-0.9	-1.8	1.0
Father’s age at death	0.9	1.3	2.6	-1.0	0.4	-1.6
Worrier / anxious feelings	0.3	0.7	1.7	-0.1	1.3	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	1.8	-1.4	-1.3	0.0
Falls in the last year	7.7	10.4	19.9	-3.3	-4.5	0.5
Hair/balding pattern: Pattern 3	2.5	3.7	6.5	1.4	2.5	-1.6
Number of live births	0.1	0.1	0.3	0.3	0.6	-0.2
Forced expiratory volume in 1-second (FEV1)	1.9	6.4	10.8	2.8	3.3	0.7
Pulse rate	1.1	1.8	3.6	1.9	1.2	0.6
Happiness	0.5	0.6	1.6	-1.3	-0.5	-0.2
Noisy workplace	3.9	4.8	10.4	-1.8	-3.2	0.8
Qualifications: A levels/AS levels or equivalent	0.8	1.7	3.2	1.3	1.8	-0.4
Serious illness, injury or assault of a close relative in last 2 years	2.9	3.4	5.5	2.2	2.3	0.2
Mouth/teeth dental problems: Dentures	0.3	0.6	1.0	1.0	0.9	-0.0
Asthma	5.6	11.1	15.7	-4.0	-3.6	-2.1
Medication: Ibuprofen (e.g. Nurofen)	2.8	3.5	6.0	-2.1	-2.5	-0.3
Medication: Cholesterol lowering	0.6	0.9	1.6	-0.2	-1.0	1.2
Depression (self-reported)	0.3	0.4	1.0	-0.3	0.3	-1.0
Medication: Lansoprazole	0.5	0.6	1.1	-0.7	-0.4	-1.1
Prospective memory result	0.6	0.8	1.6	0.6	1.2	0.7
Lung cancer (father)	2.4	2.8	4.8	-1.8	-2.2	-0.7
Illnesses of mother	0.2	0.2	0.6	0.2	-0.3	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.0	8.5	2.9	2.9	0.9
Pulse wave Arterial Stiffness index	1.2	1.4	2.7	-1.6	-0.7	-0.9
Impedance of arm (left)	0.1	0.5	1.5	-1.2	-0.3	-0.2
Arm fat mass (right)	1.6	6.6	11.7	-2.7	-3.4	-0.8
Trunk predicted mass	0.3	1.9	3.8	1.9	0.8	1.1
Standing height	1.2	12.3	18.1	4.3	3.5	2.6
Length of working week for main job	0.9	1.0	2.2	0.6	-0.6	1.5
Exposure to tobacco smoke at home	6.4	7.2	12.5	-3.0	-3.5	-0.4
Breastfed as a baby	0.3	0.3	0.9	0.2	-0.0	0.9
Tense / ‘highly strung’	0.2	0.3	0.5	-0.7	0.1	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.2	4.2	-2.0	-1.7	-1.5
Hair/balding pattern: Pattern 4	0.5	1.2	2.1	-1.4	-1.1	-0.5
Birth weight of first child	0.2	0.4	0.6	-0.8	-0.2	-0.7
Peak expiratory flow (PEF)	0.4	0.9	1.6	0.1	1.0	-1.3
Pulse wave reflection index	10.2	12.6	19.6	-4.4	-4.2	-0.9
Ever highly irritable/argumentative for 2 days	1.3	1.6	2.4	-1.5	-1.6	-0.4
Loud music exposure frequency	0.3	0.3	0.7	-0.8	-0.1	0.5
Qualifications: O levels/GCSEs or equivalent	1.8	2.8	4.7	2.2	1.8	0.8
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.0	-0.8	0.1	-1.4
Blood clot in the leg (DVT)	0.3	0.4	0.5	0.7	0.7	0.5
Medication: Paracetamol	5.3	8.8	14.5	-3.3	-3.8	-1.0
Headache pain in last month	8.3	14.3	19.4	-4.4	-3.1	-3.7
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	2.6	-0.9	0.0	-1.6
Glaucoma (self-reported)	1.6	1.8	3.4	1.8	0.7	1.3
Gout (self-reported)	0.4	0.5	0.9	-0.7	-0.3	-0.9
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.3	0.5	0.2	0.4
Medication: Amlodipine	0.5	0.7	1.1	-0.3	-0.9	1.0
Medication: Ventolin 100micrograms inhaler	2.8	3.6	5.8	-2.4	-2.1	-0.8
Birth weight	0.1	0.3	0.7	-0.4	-0.8	0.1
Chronic bronchitis/emphysema (mother)	3.1	3.7	7.9	-1.7	-2.8	0.5
High blood pressure (siblings)	0.6	0.9	2.0	-1.4	-0.7	-0.5
Forced vital capacity (FVC), Best measure	3.5	13.0	18.7	4.2	4.3	1.7
Body fat percentage	2.3	8.9	16.1	-3.2	-4.0	-0.8
Leg fat percentage (right)	3.3	12.0	23.2	-3.5	-4.8	-0.7
Arm fat-free mass (right)	0.5	2.5	5.1	2.2	0.5	1.5
Exposure to tobacco smoke outside home	3.0	4.0	8.6	-1.9	-2.9	-0.1
Comparative body size at age 10	0.7	2.0	2.9	1.7	1.7	-0.4
Number of full brothers	2.0	2.6	3.8	-1.9	-1.9	-0.3
Worry too long after embarrassment	1.0	1.7	3.7	-1.9	-1.2	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	2.2	2.9	3.6	-1.8	-1.9	-1.3
Wheeze or whistling in the chest in last year	7.8	13.9	21.2	-4.6	-3.7	-2.6
Number of children fathered	0.1	0.1	0.3	0.3	-0.5	0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	3.5	1.6	1.9	-0.2
Age at first live birth	1.8	3.1	4.6	2.1	0.8	2.0
Pulse wave peak to peak time	1.8	2.1	4.0	2.0	0.9	1.2
Health satisfaction	0.3	0.4	0.6	-0.8	-0.7	-0.4
Shortness of breath walking on level ground	1.3	1.5	2.6	-1.6	-1.4	-0.3
Qualifications: College or University degree	0.6	1.9	3.3	1.8	0.9	1.2
Eye problems/disorders: None of the above	2.5	2.9	5.0	-0.2	1.9	-2.2
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.0	0.4	-0.6	1.0
Emphysema/chronic bronchitis	3.1	3.5	7.3	-1.8	-2.7	0.3
Medication for pain relief, constipation, heartburn	2.5	4.3	6.8	2.4	2.6	0.4
Neck or shoulder pain in last month	2.1	3.0	6.2	-1.6	-0.5	-2.5
Medication: Blood pressure	3.9	6.9	9.2	3.0	1.6	3.0
Angina (self-reported)	6.8	8.9	12.6	3.5	1.8	3.3
Migraine (self-reported)	8.0	9.9	17.1	-3.5	-4.1	-0.7
Medication: Ibuprofen	2.2	2.7	4.3	-1.9	-2.1	-0.3
Medication: Allopurinol	0.5	0.6	1.0	0.2	0.9	-1.0
Medication: Omeprazole	0.0	0.1	0.1	0.1	0.4	0.1
Medication: Seretide 50 evohaler	1.5	1.8	3.4	-1.4	-1.8	-0.2
Mean time to correctly identify matches	1.2	2.2	4.1	1.6	2.0	-0.2
Heart disease (mother)	2.1	2.5	3.6	1.9	1.9	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	1.9	-1.4	-0.6	-0.6
Whole body fat mass	1.3	5.3	10.8	-2.2	-3.3	-0.3
Leg fat mass (right)	1.8	6.9	15.1	-2.4	-3.9	-0.2
Arm predicted mass (right)	0.6	3.0	6.2	2.5	0.9	1.4
Pulse rate, automated reading	0.3	0.9	1.6	1.3	0.2	1.0
Alcohol intake frequency.	1.8	4.2	6.7	-2.0	-2.6	-1.3
Comparative height size at age 10	0.3	1.8	3.3	1.4	-0.5	1.8
Number of full sisters	5.5	6.7	10.1	-3.2	-3.2	-0.1
Suffer from ‘nerves’	1.3	2.0	3.5	-1.9	-1.0	-1.2
Overall health rating	1.5	3.3	5.8	-2.0	-2.4	-0.3
Chest pain or discomfort	0.6	0.9	1.1	-1.0	-1.0	-0.7
Had major operations	0.1	0.1	0.2	-0.3	-0.4	-0.4
Age at last live birth	1.9	2.7	4.3	2.1	1.4	1.4
Family relationship satisfaction	0.2	0.3	0.7	-0.8	-0.2	-0.4
Leg pain on walking	0.2	0.3	0.7	0.0	-0.4	0.8
Qualifications: NVQ or HND or HNC or equivalent	2.4	2.8	4.4	-2.1	-0.5	-2.0
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.2	1.1	1.0	-0.0
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.7	0.8	0.5	1.3
Medication: Aspirin	1.8	2.4	4.9	1.5	-0.0	2.2
Supplements: Vitamin C	0.7	0.9	1.6	0.5	-0.8	1.3
Knee pain experienced in last month	5.1	7.9	12.2	-3.3	-3.5	-0.5
Hypertension (Self-reported)	1.2	3.4	8.1	1.5	-0.4	2.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.7	3.2	4.9	-2.0	-2.2	-0.9
Illnesses of father: Heart disease	8.3	11.5	18.3	4.3	3.5	2.0
Illnesses of siblings: Diabetes	0.1	0.1	0.2	0.1	0.0	0.5
Smoking status: Previous	0.1	0.2	0.2	-0.4	0.5	0.5
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.2	5.2	2.3	1.2	1.8
Whole body fat-free mass	0.2	1.4	2.8	1.7	0.4	1.1
Leg fat-free mass (right)	0.1	0.5	1.1	1.0	0.1	0.6
Arm fat percentage (left)	2.9	11.5	18.6	-3.8	-4.3	-1.4
Average weekly red wine intake	3.4	4.9	10.3	2.1	0.4	3.2
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.4	1.0	0.3	1.2
Mood swings	2.6	4.6	8.6	-2.9	-1.7	-1.5
Loneliness, isolation	5.7	7.8	13.0	-3.6	-2.2	-2.4
Long-standing illness, disability or infirmity	3.4	5.1	8.3	-2.4	-2.9	-1.1
Ever had bowel cancer screening	2.1	2.5	6.2	-0.9	0.6	-2.5
Diabetes diagnosed by doctor	1.3	2.1	2.7	-1.7	-1.1	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.0	-0.4	-1.4	0.7
Friendships satisfaction	0.1	0.2	0.4	-0.2	0.7	0.0
Qualifications: nursing, teaching	0.2	0.3	0.8	0.9	0.4	0.3
Commuting to job workplace: Walk	1.1	1.2	1.7	-1.3	-1.3	-0.3
Eye problems/disorders: Cataract	1.6	1.9	3.6	-0.3	-1.4	1.9
Mouth/teeth dental problems: Mouth ulcers	1.7	2.6	4.9	-1.7	-0.4	-2.2
Medication for cholesterol	2.2	3.4	7.3	1.5	2.7	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	2.3	-1.5	-0.4	-1.3
Back pain experienced in last month	1.7	2.4	2.8	-1.7	-1.4	-1.5
Mineral and other dietary supplements	2.8	3.7	8.4	1.7	2.9	0.1
Breast cancer (self-reported)	1.0	1.2	2.3	1.0	0.4	1.5
Asthma (self-reported)	5.6	11.1	15.5	-3.9	-3.7	-2.1
Osteoporosis (self-reported)	3.0	3.7	8.3	-1.7	-2.9	-0.1
Osteoarthritis (self-reported)	5.1	6.7	9.4	-3.0	-3.1	-1.3
Medication: Aspirin	1.7	2.2	4.3	1.5	0.2	2.1
Medication: Gliclazide	1.1	1.2	2.0	-1.1	-0.7	-1.4
Illnesses of father: None of the above (group 1)	0.3	0.4	0.9	0.2	-0.4	1.0
Smoking status: Current	8.5	13.6	20.3	-4.5	-4.4	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.4	-0.4	-0.6	-0.3
Whole body water mass	0.3	1.5	3.1	1.8	0.6	1.1
Leg predicted mass (right)	0.1	0.5	1.1	1.1	0.1	0.6
Arm fat mass (left)	1.4	5.6	10.7	-2.4	-3.3	-0.7
Number of self-reported non-cancer illnesses	5.5	9.5	15.3	-3.4	-3.9	-1.2
Average weekly champagne plus white wine intake	0.9	1.2	3.2	-0.3	-1.8	0.4
Miserableness	7.0	12.2	21.4	-4.6	-2.7	-2.8
Guilty feelings	7.2	10.9	19.1	-4.4	-3.0	-2.1
Wears glasses or contact lenses	0.5	0.5	0.9	-0.8	-0.4	-0.9
Ever taken oral contraceptive pill	0.6	0.7	1.5	0.7	-0.3	1.2
Hearing aid user	0.6	0.7	1.9	0.1	-0.5	1.4
Mother’s age at death	0.3	0.4	0.6	-0.1	0.7	-0.8
Financial situation satisfaction	0.2	0.3	0.5	-0.7	-0.1	-0.6
Tinnitus: Yes, now most or all of the time	1.5	1.8	4.6	0.7	-0.4	2.1
Commuting to job workplace: Public transport	1.4	1.7	4.2	-0.9	-2.0	0.3
Eye problems/disorders: Glaucoma	1.0	1.2	1.8	1.3	0.3	1.3
Medication: Blood pressure	0.8	1.6	2.0	1.4	1.0	1.4
Pain type(s) experienced in last month: Hip pain	1.3	1.6	2.9	0.4	1.3	-1.7
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.2	-0.1	-1.1	0.4
High cholesterol (Self-reported)	7.5	13.3	25.1	-3.8	-5.0	-0.3
Medication: Bendroflumethiazide	0.5	0.8	1.1	1.1	1.0	0.5
Medication: Paracetamol	2.8	4.4	8.8	-2.1	-3.0	0.1
Medication: Lisinopril	3.2	4.1	5.0	2.2	2.2	1.6
Medication: Atorvastatin	2.3	2.9	4.9	-2.2	-1.3	-1.5
Illnesses of father: High blood pressure	3.2	4.0	6.2	-2.5	-2.2	-1.0
Alcohol drinker status: Never	0.3	0.3	0.8	0.2	-0.9	0.2
Ever smoked	2.9	5.2	9.8	-3.1	-2.4	0.2
Basal metabolic rate	0.1	0.8	1.5	1.2	0.0	0.9
Leg fat percentage (left)	3.9	14.2	25.9	-3.9	-5.1	-1.1
Arm fat-free mass (left)	0.3	1.5	2.6	1.6	0.2	1.4
Number of operations (self-reported)	0.1	0.1	0.2	0.5	-0.1	0.1
Average weekly beer plus cider intake	0.4	0.6	0.7	-0.6	-0.8	0.9
Irritability	2.8	4.7	8.1	-2.5	0.0	-2.8
Risk taking	4.0	5.8	9.6	-2.8	-3.1	-0.1
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.7	-0.6	0.2	-0.8
Fractured/broken bones in last 5 years	1.6	2.1	4.7	-1.2	-2.2	0.5
Age started oral contraceptive pill	2.6	3.3	5.4	2.3	1.6	1.4
Diastolic blood pressure, automated reading	3.5	10.8	17.7	-4.2	-3.7	-1.0
Ever depressed for a whole week	4.4	5.4	7.1	-2.7	-2.5	-1.6
Unable to work because of sickness or disability	0.3	0.4	0.7	0.8	0.6	0.5
Commuting to job workplace: Cycle	0.8	1.0	1.8	-1.4	-0.9	-0.5
Myopia	0.6	0.9	1.4	0.3	1.2	-1.2
Vascular/heart problems diagnosed by doctor	2.0	5.4	12.5	-1.9	0.3	-3.5
Cholesterol lowering medication	7.7	11.4	22.0	-3.5	-4.7	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.2	0.1	-0.4
Pain experienced in last month	4.1	6.8	10.4	3.2	2.3	2.2
Supplements: Calcium	4.5	4.9	12.1	-1.6	-3.5	0.4
Basal cell carcinoma (self-reported)	0.2	0.2	0.6	-0.2	0.2	-0.7
Heart attack/myocardial infarction (self-reported)	11.9	15.3	20.5	4.5	3.1	4.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	0.8	0.8	0.9	0.7
Heart disease (siblings)	3.1	3.8	7.8	1.5	2.8	-1.2
Alcohol drinker status: Previous	2.3	2.6	3.9	-2.0	-1.6	-1.1
Pack years of smoking	3.9	5.7	7.2	-2.7	-2.7	-1.6
Impedance of whole body	0.1	0.3	0.6	-0.8	-0.3	0.4
Leg fat mass (left)	2.0	7.7	15.9	-2.6	-4.0	-0.6
Arm predicted mass (left)	0.2	0.9	1.7	1.3	-0.1	1.0