TWAS hub - NOP58

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0480	0.0200	0.00130	0.016	0.026	0.013	0.026	0.016	4.4e-03	3.2e-04	8.2e-03	3.7e-04	4.3e-03
2	GTEx	Muscle Skeletal	0.0597	0.0241	0.00130	0.005	NA	-0.003	NA	0.004	9.2e-02	NA	9.0e-01	NA	1.2e-01
3	NTR	Blood	0.0179	0.0072	0.00044	0.008	0.010	0.001	0.010	0.003	1.2e-03	2.4e-04	9.2e-02	2.8e-04	3.2e-02
4	YFS	Blood	0.0813	0.0172	0.00000	0.142	0.131	0.138	0.138	0.142	5.0e-44	1.1e-40	6.1e-43	8.9e-43	4.0e-44
5	TCGA	Lung Adenocarcinoma	0.0238	0.0153	0.00300	0.022	0.026	0.021	NA	0.023	1.2e-03	4.8e-04	1.5e-03	NA	8.1e-04
6	TCGA	Prostate Adenocarcinoma	0.0460	0.0239	0.00002	0.057	0.041	0.038	NA	0.046	1.3e-06	3.4e-05	7.3e-05	NA	1.4e-05
7	TCGA	Thyroid Carcinoma	0.0310	0.0210	0.00200	0.027	0.024	0.009	NA	0.022	1.1e-03	2.0e-03	4.4e-02	NA	2.9e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
High cholesterol (Self-reported)	16.1	28.6	46.4	6.8	6.4	5.2	3.5	4.2	5.7	4.9
Medication: Simvastatin	10.5	15.4	24.0	4.2	4.9	3.2	3.1	3.6	4.2	3.9
Medication: Cholesterol lowering	9.8	15.2	21.0	4.6	4.6	2.9	3.5	3.8	4.0	3.7
Age when periods started (menarche)	7.3	17.6	24.0	-4.0	-4.9	-4.6	-2.5	-3.9	-4.9	-4.1
Cholesterol lowering medication	5.8	8.5	17.9	4.2	3.5	3.2	1.4	1.8	2.9	2.5
Osteoarthritis (self-reported)	5.4	7.1	11.0	3.1	2.7	0.8	3.3	2.6	2.5	2.8
Medication: Paracetamol	4.9	8.2	11.1	2.9	3.3	3.1	1.7	2.7	3.2	2.7
Forced vital capacity (FVC)	4.8	18.5	28.7	-5.4	-4.6	-2.4	-4.9	-3.9	-4.0	-4.3
Forced vital capacity (FVC), Best measure	4.8	17.4	29.8	-5.4	-4.2	-1.8	-5.5	-3.5	-3.6	-4.1
Time employed in main current job	4.4	5.1	6.6	-2.4	-2.3	-2.0	-2.1	-2.1	-2.6	-2.3
Heel T-Score	4.3	34.3	60.4	-2.9	-7.7	-6.2	-2.4	-5.9	-7.8	-5.8
Medication: Atorvastatin	4.3	5.4	12.9	3.6	2.3	1.8	2.4	1.7	1.9	2.0
Illnesses of siblings	4.1	5.7	11.9	-3.5	-2.1	-0.9	-2.5	-2.4	-2.3	-2.5
Hand grip strength (left)	4.0	10.5	13.8	-3.7	-3.4	-2.7	-2.6	-3.1	-3.7	-3.3
Medication for cholesterol, blood pressure or diabetes	4.0	6.6	9.4	-2.5	-3.1	-2.5	-1.4	-2.7	-2.9	-2.5
Number of full sisters	3.9	4.8	12.4	1.5	1.9	-0.1	3.5	2.3	1.9	2.4
Eye problems/disorders: Glaucoma	3.9	4.6	6.6	-2.3	-1.8	-1.1	-2.6	-2.2	-2.2	-2.5
Reaction Time	3.8	7.3	12.3	-3.5	-2.8	-1.8	-2.9	-2.4	-2.4	-2.7
Hair/balding pattern: Pattern 4	3.8	9.3	14.8	1.4	3.5	2.2	2.5	3.5	3.8	3.5
Triglycerides	3.7	6.1	8.2	2.6	2.9	2.7	1.9	2.2	2.6	2.4
Medication for hormone replacement therapy	3.6	4.0	7.5	2.5	1.8	0.5	2.7	1.8	1.7	2.1
Heel bone mineral density (BMD) T-score, automated (left)	3.6	8.1	13.5	-1.7	-3.6	-3.4	-1.5	-2.6	-3.7	-2.7
Arm fat percentage (right)	3.6	14.2	28.5	5.3	3.8	3.4	2.8	3.4	3.8	3.4
Height	3.5	68.4	100.0	-8.0	-8.8	-4.4	-10.0	-8.1	-8.6	-8.9
Number of treatments/medications taken	3.5	6.3	15.3	3.9	2.6	2.8	1.2	1.8	2.4	1.9
Townsend deprivation index at recruitment	3.5	5.0	11.3	2.4	2.3	1.0	3.4	1.8	1.9	2.2
Standing height	3.5	34.6	41.2	-5.4	-6.4	-4.0	-6.2	-6.0	-6.4	-6.4
Arm fat percentage (left)	3.5	13.9	30.1	5.5	3.6	3.6	2.6	3.3	3.6	3.3
Type 2 Diabetes (T2D) (2012)	3.4	4.0	7.3	1.4	2.2	2.7	1.0	1.7	2.3	2.0
Hand grip strength (right)	3.4	9.1	11.9	-2.8	-3.1	-1.6	-3.2	-3.3	-3.5	-3.3
Mean time to correctly identify matches	3.2	6.0	9.9	-3.1	-2.4	-1.9	-2.4	-2.3	-2.4	-2.5
Medication: Paracetamol	3.2	5.0	7.2	2.1	2.7	2.7	1.0	2.1	2.6	1.9
Type 2 Diabetes (T2D) (2018)	3.1	5.8	8.8	3.0	2.7	2.2	1.9	2.4	2.2	2.5
Noisy workplace	3.1	3.9	7.1	1.2	2.1	2.0	1.1	2.0	2.7	2.2
Exposure to tobacco smoke outside home	3.1	4.2	5.3	1.9	2.0	1.6	2.3	2.0	2.2	2.2
Lung FVC	3.0	15.3	37.6	-6.1	-3.8	-2.9	-3.7	-3.1	-3.3	-3.6
High blood pressure (mother)	3.0	4.1	6.5	1.5	2.2	2.5	0.8	2.2	2.5	1.9
Glaucoma (self-reported)	3.0	3.5	7.2	-2.1	-1.4	-0.3	-2.7	-1.9	-1.6	-2.2
Gout (self-reported)	3.0	4.1	6.8	1.5	2.6	1.9	1.7	2.0	2.4	1.9
Health satisfaction	3.0	3.9	5.4	2.0	2.2	1.6	1.6	2.1	2.3	1.9
Ever had bowel cancer screening	3.0	3.5	8.5	-0.5	-1.3	1.2	-2.9	-2.4	-1.4	-2.1
Medication for cholesterol	3.0	4.6	11.3	-3.4	-2.1	-1.8	-1.2	-1.7	-2.2	-1.9
Alzheimer’s Disease (in father)	2.9	3.1	5.0	1.6	2.2	1.6	1.6	1.6	1.8	1.8
Fasting Glucose	2.9	3.5	7.0	1.7	2.6	0.7	2.3	1.9	1.0	2.0
Heel bone mineral density (BMD) T-score, automated (right)	2.9	6.8	10.8	-1.5	-3.2	-2.3	-2.4	-2.4	-3.3	-2.7
Age at first live birth	2.9	5.1	12.8	-3.2	-1.7	-0.3	-3.6	-1.8	-1.6	-2.1
Medication: Allopurinol	2.9	3.8	6.1	1.3	2.5	2.1	1.2	2.0	2.4	1.8
Crohns Disease (2012)	2.8	4.5	9.5	-3.1	-2.2	-0.9	-1.9	-1.8	-2.2	-2.1
Cardiovascular Disease	2.8	9.1	21.7	4.7	3.1	2.8	1.6	2.3	3.2	2.6
Hair/balding pattern: Pattern 2	2.8	3.6	8.3	-1.2	-2.3	-2.9	0.2	-1.4	-2.4	-1.5
Chronic bronchitis/emphysema (mother)	2.8	3.2	5.8	2.4	1.6	1.8	1.5	1.5	1.8	1.8
Number of self-reported non-cancer illnesses	2.8	4.9	11.6	3.4	2.5	2.6	0.9	1.3	2.0	1.7
Relative age voice broke	2.7	4.1	6.0	-1.6	-2.3	-1.8	-1.1	-2.4	-2.4	-2.2
Pain all over the body in last month	2.7	2.9	4.4	-1.4	-1.5	-0.5	-2.1	-1.9	-1.9	-2.1
Forced expiratory volume in 1-second (FEV1), Best measure	2.7	8.7	20.2	-3.6	-2.9	-0.4	-4.5	-2.4	-2.3	-2.9
Seen doctor (GP) for nerves, anxiety, tension or depression	2.7	4.1	11.7	3.4	1.5	2.5	1.1	1.5	1.6	1.5
Leg fat percentage (right)	2.7	9.8	18.9	4.3	3.2	2.8	2.2	3.0	3.1	2.9
Forced expiratory volume in 1-second (FEV1), predicted	2.7	5.6	11.4	-2.5	-2.6	-0.7	-3.4	-2.0	-2.1	-2.4
BMI	2.6	15.2	20.5	4.4	4.1	4.5	1.3	3.9	4.4	3.7
Forced expiratory volume in 1-second (FEV1)	2.6	8.8	14.9	-3.6	-3.2	-1.1	-3.9	-2.7	-2.6	-3.0
Commuting to job workplace: Cycle	2.6	3.2	5.2	-1.3	-2.0	-2.3	-0.4	-2.1	-1.9	-1.7
Ovarian Cancer	2.5	3.4	4.9	-1.3	-1.9	-0.7	-2.0	-2.0	-2.2	-2.2
Fed-up feelings	2.5	4.6	15.8	1.6	1.2	-0.9	4.0	2.2	1.3	2.3
Leg fat percentage (left)	2.5	9.1	18.1	4.3	3.1	2.4	2.4	2.8	2.9	2.8
LDL Cholesterol	2.4	3.8	7.0	2.0	2.0	1.0	2.6	1.8	1.9	2.0
Hearing difficulty/problems: Yes	2.4	3.7	6.2	1.2	2.5	1.0	1.8	2.1	2.1	2.1
Diabetes (mother)	2.4	3.0	5.1	2.1	1.6	0.8	2.3	1.5	1.6	1.8
High blood pressure (siblings)	2.4	3.5	6.7	2.6	1.7	1.2	1.8	1.7	1.9	1.9
Number of full brothers	2.4	3.0	9.1	2.1	1.4	0.0	3.0	1.3	1.1	1.6
Long-standing illness, disability or infirmity	2.3	3.5	9.9	3.1	1.7	1.0	2.1	1.5	1.4	1.5
Body mass index (BMI)	2.2	9.3	13.2	3.5	3.1	3.6	0.7	3.1	3.5	2.8
Had other major operations	2.2	2.6	9.5	1.1	1.7	3.1	-1.1	0.9	1.5	0.8
Alcohol intake versus 10 years previously	2.2	3.3	6.2	0.2	2.3	0.7	1.6	2.1	2.5	2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.2	2.6	3.7	-1.4	-1.7	-1.3	-1.0	-1.9	-1.9	-1.8
Prospective memory result	2.1	2.6	6.4	-2.2	-1.7	-2.5	-0.3	-0.9	-1.4	-1.0
Lung cancer (father)	2.1	2.4	4.4	1.2	2.1	1.0	1.9	1.3	1.5	1.6
Qualifications: CSEs or equivalent	2.0	2.6	4.1	1.4	1.5	2.0	0.9	1.5	2.0	1.6
Sitting height	2.0	14.0	32.9	-3.5	-3.6	-0.7	-5.7	-3.4	-3.4	-4.0
Alcohol intake frequency.	2.0	4.7	5.8	2.1	2.4	2.4	1.1	2.4	2.2	2.3
Verbal and Numeric Reasoning (VNR)	1.9	4.5	15.0	1.2	1.9	3.9	-2.5	1.1	1.9	0.6
Eye problems/disorders: None of the above	1.9	2.2	8.1	1.4	0.5	-0.7	2.8	1.1	0.9	1.6
Medication for pain relief, constipation, heartburn	1.9	3.2	4.7	-2.0	-2.2	-2.1	-0.8	-1.4	-1.9	-1.6
Illnesses of father: Heart disease	1.9	2.6	6.2	1.9	1.7	2.5	-0.2	1.6	1.3	1.2
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	5.3	2.3	1.4	1.4	1.5	0.6	1.3	1.1
Hayfever, allergic rhinitis or eczema	1.8	3.9	6.0	2.4	2.1	2.2	1.9	1.2	1.9	1.8
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	5.7	2.4	1.4	1.4	1.2	1.2	1.4	1.5
Hair/balding pattern: Pattern 3	1.8	2.6	7.3	1.2	2.1	2.7	-0.6	0.9	1.6	1.1
Wheeze or whistling in the chest in last year	1.8	3.2	4.8	2.2	2.1	1.6	1.5	1.3	1.9	1.7
Illnesses of siblings: Diabetes	1.8	2.3	3.3	1.7	1.5	0.7	1.3	1.8	1.7	1.6
Alcohol drinker status: Never	1.8	2.1	8.6	1.1	1.1	2.9	-1.5	0.6	1.0	0.4
Allergy	1.7	3.9	6.7	-2.0	-2.1	-1.4	-2.6	-1.5	-1.9	-2.0
Body fat percentage	1.7	6.7	18.0	4.2	2.4	2.0	2.0	2.3	2.3	2.2
Financial situation satisfaction	1.7	2.1	3.7	1.0	1.7	0.7	1.1	1.7	1.9	1.7
Rheumatoid Arthritis	1.6	2.2	5.6	2.4	1.8	1.4	1.1	0.9	1.2	1.0
Allergy or Eczema	1.6	4.2	8.7	3.0	2.2	2.3	2.0	0.9	1.7	1.6
Lung FEV1/FVC ratio	1.6	8.0	10.9	2.7	3.3	1.9	2.4	2.9	3.2	3.1
Pain experienced in last month	1.6	2.6	4.4	0.5	1.9	0.5	2.1	1.9	1.8	1.7
Alzheimer’s Disease (including proxy)	1.5	2.2	8.8	0.9	1.2	-0.4	3.0	1.0	0.8	1.6
Coronary Artery Disease (CAD)	1.5	1.8	4.8	-1.7	-1.2	-0.2	-2.2	-0.8	-1.1	-1.3
Ever had hysterectomy (womb removed)	1.5	1.7	4.5	0.7	1.4	2.1	0.2	1.0	1.6	1.1
Neck or shoulder pain in last month	1.5	2.2	5.7	2.4	1.3	2.0	0.2	1.1	1.2	1.1
Comparative height size at age 10	1.5	8.0	13.8	-2.6	-2.7	-1.3	-3.7	-3.0	-2.8	-3.1
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	2.7	-1.6	-1.0	-1.1	-0.8	-1.3	-1.3	-1.4
Back pain experienced in last month	1.5	2.2	4.8	-1.2	-1.7	-0.6	-2.2	-1.4	-1.4	-1.4
Tinnitus: Yes, now most or all of the time	1.5	1.7	5.5	1.1	1.1	-0.2	2.4	1.1	1.0	1.2
Financial difficulties in last 2 years	1.4	1.8	3.3	0.7	1.2	0.5	1.8	1.6	1.4	1.7
Fluid intelligence score	1.4	3.0	10.2	0.6	1.4	3.2	-1.8	1.0	1.8	0.6
Length of working week for main job	1.4	1.6	3.1	0.8	1.3	1.4	0.6	1.3	1.8	1.3
Pulse wave reflection index	1.4	1.7	3.1	1.1	1.4	0.7	1.8	1.0	1.7	1.3
Loud music exposure frequency	1.4	1.5	2.4	0.7	1.5	0.8	1.1	1.3	1.5	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	4.8	1.8	1.1	2.2	-0.1	0.7	1.4	0.9
Overall health rating	1.4	2.9	5.5	2.3	1.9	2.3	0.4	1.3	1.7	1.2
Arm fat mass (left)	1.4	5.8	11.2	3.3	2.3	2.9	0.6	2.2	2.5	2.0
Number of operations (self-reported)	1.4	2.0	7.5	1.6	1.1	2.7	-1.1	0.5	1.1	0.6
Smoking Status	1.3	3.2	10.7	-0.2	-1.2	-3.3	3.1	-0.5	-0.6	0.2
Arm fat mass (right)	1.3	5.1	9.9	3.1	2.1	2.7	0.6	2.1	2.4	1.9
Comparative body size at age 10	1.3	3.6	11.4	2.3	1.4	3.4	-1.4	1.0	1.7	0.9
Age at last live birth	1.3	1.8	3.4	-1.8	-1.1	-0.8	-1.8	-1.0	-1.3	-1.2
Diabetes diagnosed by doctor	1.3	2.1	2.9	1.7	1.7	1.4	0.9	1.5	1.4	1.5
Ever taken oral contraceptive pill	1.3	1.4	2.2	-1.4	-1.1	-1.5	-1.2	-0.7	-1.1	-1.2
Heart disease (siblings)	1.3	1.6	2.6	1.6	0.9	-0.1	1.5	1.6	1.1	1.4
Medication: Levothyroxine sodium	1.2	2.0	3.8	1.3	1.3	-0.2	2.0	1.6	1.2	1.7
Hearing difficulty/problems with background noise	1.2	2.0	3.8	1.2	1.9	1.4	1.2	1.2	1.4	1.4
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	3.9	2.0	1.4	1.0	1.3	1.2	1.4	1.2
Illnesses of mother	1.2	1.5	2.3	-1.2	-1.4	-0.6	-1.5	-1.2	-1.3	-1.3
Peak expiratory flow (PEF)	1.2	2.8	4.8	-0.5	-1.9	-0.2	-1.8	-2.2	-1.8	-2.0
Medication: Blood pressure	1.2	2.1	3.8	0.4	1.8	1.5	-0.0	1.9	1.8	1.5
Leg fat mass (right)	1.2	4.6	7.8	2.8	2.2	2.6	0.2	2.1	2.2	1.8
Arm predicted mass (right)	1.2	6.0	24.7	-2.5	-2.0	0.6	-5.0	-1.2	-1.3	-1.9
Basal cell carcinoma (self-reported)	1.2	1.4	2.9	-0.4	-1.1	-0.0	-1.1	-1.5	-1.7	-1.4
Trunk fat percentage	1.1	4.2	15.4	3.9	1.7	1.3	1.7	1.5	1.5	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	5.6	0.8	-0.8	-1.8	2.4	-0.0	-0.6	0.2
Taking other prescription medications	1.1	1.8	3.9	2.0	1.2	1.4	1.2	0.9	1.2	1.2
Impedance of leg (left)	1.1	5.3	13.1	-1.0	-1.8	-3.6	1.4	-2.3	-2.9	-1.9
Waist circumference	1.1	3.9	6.4	2.5	2.1	2.5	0.0	1.7	2.2	1.5
Alcohol usually taken with meals	1.1	1.8	4.2	1.7	-0.7	2.0	-2.0	-0.6	-0.3	-0.7
Diabetes (self-reported)	1.1	1.7	2.2	1.5	1.5	1.3	1.0	1.2	1.3	1.2
Qualifications: A levels/AS levels or equivalent	1.1	2.4	10.8	-0.8	0.4	2.2	-3.3	-0.1	0.5	-0.5
Arm fat-free mass (right)	1.1	5.5	22.8	-2.4	-1.9	0.6	-4.8	-1.1	-1.3	-1.9
Heart disease (mother)	1.1	1.3	2.4	1.2	1.4	1.5	-0.0	1.2	1.1	0.8
Knee pain experienced in last month	1.1	1.6	5.1	1.4	0.7	-1.1	2.3	0.8	0.8	1.1
Miserableness	1.1	1.8	5.6	1.4	0.6	-0.3	2.4	1.1	1.1	1.5
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	2.2	-1.5	-1.2	-1.2	-0.8	-1.1	-1.3	-1.2
Leg fat mass (left)	1.1	4.1	8.1	2.9	2.0	2.4	0.3	1.9	2.1	1.7
Lupus	1.0	1.5	5.3	-1.0	0.0	1.9	-2.3	-0.1	0.3	-0.6
Primary Biliary Cirrhosis	1.0	1.4	1.9	1.3	1.3	0.4	1.2	1.3	1.4	1.3
Respiratory disease	1.0	2.3	8.8	3.0	0.9	1.0	1.9	0.6	0.8	1.0
Stomach or abdominal pain in last month	1.0	1.3	3.6	0.5	-0.3	1.9	-1.7	-1.0	-0.3	-0.8
Medication: Atenolol	1.0	1.2	2.6	-0.2	1.6	1.3	-0.5	1.4	1.1	0.9
Trunk fat-free mass	1.0	5.9	22.5	-2.7	-1.9	0.5	-4.7	-1.3	-1.3	-2.0
Trunk predicted mass	1.0	6.0	22.8	-2.7	-1.9	0.5	-4.8	-1.4	-1.3	-2.0
Blood clot in the leg (DVT)	1.0	1.3	2.2	-1.5	-1.1	-1.1	-0.8	-1.0	-1.2	-1.1
Headache pain in last month	1.0	1.7	8.4	1.2	0.4	2.9	-1.3	-0.5	0.4	-0.1
Hypertension (Self-reported)	1.0	2.8	7.0	2.6	1.7	1.9	-0.2	1.3	1.8	1.3
Mood swings	1.0	1.8	3.2	1.8	1.1	0.8	1.7	1.1	1.3	1.4
Ever smoked	1.0	1.7	6.2	0.8	-0.2	-2.1	2.5	0.1	0.0	0.7
Myopia	1.0	1.4	3.5	-0.6	-1.2	-0.4	-1.9	-1.2	-1.1	-1.3
Depression (Nagel 2018)	0.9	1.4	5.6	1.1	-0.5	-1.5	2.4	0.1	-0.3	0.5
Intelligence (Savage-Jansen 2018)	0.9	2.7	9.2	0.6	1.5	3.0	-2.0	0.9	1.5	0.3
Crohns Disease (2017)	0.9	2.0	10.1	-3.2	-0.7	-0.5	-1.4	-0.1	-0.6	-0.8
Age at First Birth	0.9	1.3	2.2	-1.5	-1.1	-1.1	-1.2	-0.8	-1.1	-1.0
Ever used hormone-replacement therapy (HRT)	0.9	1.1	4.4	2.1	0.8	0.3	1.3	0.4	0.7	0.7
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	4.7	-1.1	-0.9	0.6	-2.2	-1.0	-0.9	-1.2
Friendships satisfaction	0.9	1.1	3.1	-0.4	-1.2	-1.8	0.3	-0.8	-1.2	-0.8
Smoking status: Current	0.9	1.4	4.6	-0.1	-0.4	-2.2	2.1	0.2	-0.0	0.4
Hearing aid user	0.9	1.0	2.8	1.1	0.7	-0.6	1.7	0.9	0.8	0.9
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.4	-0.2	-1.3	-1.1	-0.5	-1.6	-1.1	-1.3
Depressed Affect (Nagel 2018)	0.8	1.7	6.3	1.5	0.2	-0.5	2.5	0.9	0.7	1.2
Irritable Bowel Disease (IBD)	0.8	2.0	10.1	-3.2	-0.9	-0.5	-1.1	-0.2	-0.7	-0.8
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	4.4	2.1	0.9	1.0	0.7	0.4	0.6	0.4
Pack years adult smoking proportion	0.8	1.2	2.0	1.4	1.0	0.3	1.3	1.1	1.1	1.1
High blood pressure	0.8	2.1	5.1	2.3	1.4	1.6	-0.3	1.1	1.6	1.1
Tense / ‘highly strung’	0.8	1.4	2.1	-0.6	-1.4	-1.0	-0.9	-1.4	-1.4	-1.3
Wears glasses or contact lenses	0.8	0.9	2.2	-1.3	-1.1	-1.5	0.5	-0.5	-0.7	-0.3
Arm fat-free mass (left)	0.8	3.9	15.8	-2.3	-1.5	0.4	-4.0	-0.8	-0.9	-1.5
Fractured/broken bones in last 5 years	0.8	1.1	2.7	-1.6	-0.9	-0.6	-1.0	-1.0	-0.8	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.7	1.1	1.2	1.3	0.2	0.9	1.0	1.0
Alzheimer’s Disease (in mother)	0.7	0.8	2.2	-0.9	-0.5	-1.5	1.2	-0.6	-0.7	-0.2
HbA1C	0.7	0.8	2.8	-1.6	0.1	-0.3	-0.5	0.4	1.7	0.1
Frequency of depressed mood in last 2 weeks	0.7	0.9	2.9	1.4	-0.4	-1.2	1.7	-0.1	-0.3	0.4
Impedance of leg (right)	0.7	3.5	7.6	-0.9	-1.5	-2.8	1.1	-1.9	-2.5	-1.7
Current tobacco smoking	0.7	1.2	3.9	0.1	-0.6	-2.0	1.9	0.0	-0.1	0.3
Serious illness, injury or assault to yourself	0.7	0.8	1.3	1.0	0.9	0.8	1.1	0.8	1.0	0.8
Past tobacco smoking	0.7	1.2	4.4	0.0	0.2	2.1	-2.0	0.1	0.2	-0.4
Qualifications: None of the above	0.7	1.6	6.8	-0.5	-0.4	-2.6	1.9	-0.3	-0.6	-0.1
Asthma	0.7	1.4	6.2	1.7	0.1	-0.6	2.5	0.2	0.0	0.7
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	3.6	0.8	1.0	-0.5	1.9	1.3	0.7	1.3
Whole body fat mass	0.7	2.8	8.2	2.9	1.5	1.9	0.2	1.4	1.5	1.2
Suffer from ‘nerves’	0.7	1.1	6.2	2.5	0.3	0.9	-0.0	-0.4	0.0	-0.2
Whole body fat-free mass	0.7	3.8	17.5	-1.9	-1.4	0.7	-4.2	-0.7	-0.7	-1.4
Qualifications: nursing, teaching	0.7	1.1	1.9	0.8	1.2	1.4	-0.1	1.3	1.2	1.0
Asthma (self-reported)	0.7	1.3	6.0	1.6	0.1	-0.6	2.5	0.1	-0.0	0.7
Whole body water mass	0.7	3.8	17.4	-2.0	-1.4	0.7	-4.2	-0.7	-0.7	-1.4
Medication: Blood pressure	0.7	1.3	5.2	2.3	0.6	1.5	-0.5	0.4	0.9	0.4
Impedance of whole body	0.7	3.7	8.0	0.5	-1.4	-2.8	2.1	-2.0	-2.3	-1.5
Arm predicted mass (left)	0.7	3.7	15.4	-2.3	-1.3	0.5	-3.9	-0.7	-0.7	-1.4
Neuroticism (Nagel 2018)	0.6	1.4	4.7	1.8	0.5	-0.5	2.2	0.6	0.6	1.0
Blood Red Count	0.6	5.5	23.4	0.4	0.3	3.7	-4.8	-0.4	0.2	-0.9
Hypothyroidism (self reported)	0.6	1.4	2.8	1.2	1.1	0.0	1.7	1.3	0.9	1.3
Neuroticism	0.6	1.3	5.9	0.9	0.5	-0.8	2.4	0.6	0.6	1.0
Chronotype (morning person)	0.6	1.5	3.5	-0.8	-1.3	0.4	-1.9	-1.3	-1.0	-1.3
Supplements: Zinc	0.6	0.7	3.0	-1.1	-0.3	-1.7	0.2	0.2	-0.5	-0.1
Average weekly fortified wine intake	0.6	0.7	2.4	0.5	0.1	1.6	-1.4	-0.4	-0.2	-0.4
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.5	1.6	0.0	0.8	-0.5	-1.1	-0.2	-0.6
Pulse rate	0.6	1.1	1.7	-1.3	-1.1	-1.1	-1.0	-0.3	-1.1	-1.0
Medication: Lansoprazole	0.6	0.7	2.4	1.2	0.7	1.6	0.1	0.3	0.5	0.5
Impedance of arm (left)	0.6	2.7	6.6	1.7	-0.9	-1.9	2.6	-1.5	-1.5	-0.8
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.3	-1.5	-0.5	-0.5	-0.4	-0.9	-0.7	-1.0
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.3	-0.1	1.0	1.1	0.1	0.7	1.1	0.7
Family relationship satisfaction	0.6	0.8	2.9	-0.6	-0.6	-1.7	1.2	0.2	-0.4	0.1
Illnesses of father: None of the above (group 1)	0.6	0.7	1.8	-1.4	-0.7	-1.3	0.6	-0.3	-0.4	-0.2
Average weekly champagne plus white wine intake	0.6	0.8	3.1	0.9	0.9	1.8	-0.2	0.2	0.9	0.6
Guilty feelings	0.6	1.0	2.7	0.8	1.2	0.2	1.6	0.8	0.8	0.8
Vascular/heart problems diagnosed by doctor	0.6	1.6	3.9	-2.0	-1.4	-1.1	0.0	-1.2	-1.4	-1.0
Schizophrenia (2018)	0.5	1.1	3.0	-1.0	-1.0	-1.7	0.8	-0.4	-1.1	-0.7
Schizophrenia (2014)	0.5	1.1	3.1	-1.1	-1.3	-1.8	0.5	-0.3	-1.0	-0.5
Blood Eosinophil Count	0.5	4.0	12.3	3.5	1.1	0.8	2.9	1.0	1.5	1.6
Blood White Count	0.5	4.1	10.7	3.1	1.2	0.3	3.3	1.2	1.5	1.7
Relative age of first facial hair	0.5	1.1	3.8	-0.4	-0.9	-1.9	1.1	-0.7	-0.8	-0.3
Trunk fat mass	0.5	2.3	9.0	3.0	1.2	1.6	0.3	1.1	1.1	0.9
Had menopause	0.5	0.6	2.8	0.9	0.0	-0.7	1.7	-0.2	-0.0	0.4
Impedance of arm (right)	0.5	2.5	7.2	1.6	-0.6	-1.9	2.7	-1.4	-1.2	-0.7
Hip circumference	0.5	2.3	7.2	1.7	1.2	2.7	-1.5	0.8	1.3	0.5
Falls in the last year	0.5	0.7	2.1	0.7	-0.3	-1.4	1.4	-0.3	-0.2	0.0
Happiness	0.5	0.6	1.0	0.3	0.8	-0.3	0.9	1.0	0.8	0.9
Mouth/teeth dental problems: Dentures	0.5	0.8	1.4	-1.1	-1.0	-1.2	-0.8	-0.4	-0.8	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.3	0.7	1.1	1.1	-0.4	0.6	1.0	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	2.2	1.1	0.4	1.5	-0.2	-0.1	0.3	0.1
Qualifications: College or University degree	0.5	1.7	7.1	-0.9	-0.7	0.4	-2.7	-0.9	-0.9	-1.2
Migraine (self-reported)	0.5	0.6	1.1	0.2	-0.7	-0.5	-0.6	-1.1	-1.0	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.2	0.9	0.4	0.5	1.5	0.3	0.5	0.6
Average weekly red wine intake	0.5	0.8	1.3	1.1	-0.8	-0.5	0.0	-1.1	-1.1	-1.0
Commuting to job workplace: Walk	0.5	0.5	2.1	0.9	0.5	0.1	1.5	0.2	0.3	0.5
Medication: Bendroflumethiazide	0.5	0.7	1.5	1.2	0.7	1.2	-0.4	0.5	0.9	0.5
Basal metabolic rate	0.5	2.8	14.5	-1.2	-1.1	1.1	-3.8	-0.5	-0.4	-1.1
Ever depressed for a whole week	0.5	0.7	2.0	0.3	-0.2	1.2	-1.4	-0.8	-0.2	-0.7
Unable to work because of sickness or disability	0.5	0.6	1.8	1.3	0.5	0.3	0.7	0.8	0.6	0.6
Mean Putamen Volume	0.4	0.5	1.9	1.4	0.5	0.9	-0.2	0.0	0.4	0.1
Blood Platelet Count	0.4	4.2	11.8	2.9	2.1	3.4	-0.8	0.7	1.8	0.5
Medication: Co-codamol	0.4	0.5	1.2	0.4	-1.1	-0.6	-0.4	-0.8	-0.6	-0.6
Diabetes (father)	0.4	0.5	0.9	0.8	0.7	0.3	0.6	1.0	0.7	0.6
Leg fat-free mass (left)	0.4	1.9	10.1	-0.3	-0.4	1.6	-3.2	0.1	0.3	-0.5
Multivitamins +/- minerals	0.4	0.5	1.2	-0.1	-1.1	-0.4	-0.5	-0.8	-0.6	-0.8
Supplements: Glucosamine	0.4	0.5	0.8	0.8	0.6	0.5	0.9	0.4	0.7	0.7
Number of incorrect matches in round	0.4	0.7	0.9	-0.9	-0.9	-0.5	-0.8	-0.9	-1.0	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.5	1.2	0.6	0.9	0.5	0.8	0.7	0.7
Emphysema/chronic bronchitis	0.4	0.4	1.1	0.5	1.1	0.8	-0.5	0.4	0.8	0.3
Medication: Ibuprofen	0.4	0.4	1.1	1.1	0.6	1.0	-0.6	0.1	0.4	0.2
Medication: Seretide 50 evohaler	0.4	0.5	2.2	1.5	0.1	0.8	0.4	-0.2	0.3	0.2
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.6	0.7	0.1	1.3	-1.1	0.3	0.4	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.7	0.0	0.4	1.0	-1.3	-0.4	-0.2	-0.4
Eye problems/disorders: Cataract	0.4	0.5	1.4	-0.3	0.9	1.2	-0.8	0.2	0.6	0.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	3.3	-0.1	0.0	1.2	-1.8	-0.2	0.0	-0.2
Illnesses of father: High blood pressure	0.4	0.5	1.0	0.0	0.5	0.1	0.8	0.8	0.9	1.0
Irritability	0.4	0.8	2.5	0.8	0.1	-1.4	1.6	0.0	-0.2	0.4
Age started oral contraceptive pill	0.4	0.5	1.1	-1.1	-0.5	-0.9	-0.4	-0.6	-0.4	-0.6
Pack years of smoking	0.4	0.6	1.1	1.0	0.6	-0.1	1.1	0.7	0.7	0.8
Bipolar Disorder or Schizophrenia	0.3	0.8	2.6	-1.1	-1.0	-1.6	0.6	-0.1	-0.8	-0.4
Schizophrenia vs Biploar Disorder	0.3	0.4	0.8	-0.1	-0.8	-0.6	0.3	-0.8	-0.9	-0.5
Worry (Nagel 2018)	0.3	0.6	2.5	1.6	-0.6	-0.1	-0.0	-0.9	-0.6	-0.6
Ulcerative Colitis (UC)	0.3	0.6	2.9	-1.7	-0.5	-0.5	-0.2	-0.2	-0.4	-0.5
Prostate Cancer	0.3	0.5	0.9	0.2	0.5	-0.1	1.0	0.8	0.8	0.9
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	1.0	0.4	0.9	0.3	0.3	0.4	0.3
HDL Cholesterol	0.3	0.5	0.9	0.9	-0.8	-0.6	0.1	-0.9	-0.7	-0.5
Tanning	0.3	3.3	8.2	-2.9	-1.7	-2.2	0.1	-1.5	-1.8	-1.4
Sensitivity / hurt feelings	0.3	0.5	2.1	0.0	-0.5	-1.4	0.8	0.0	-0.4	-0.1
Medication: Metformin	0.3	0.4	1.5	0.3	0.1	1.2	-0.8	-0.4	-0.2	-0.4
Severe depression (siblings)	0.3	0.3	0.8	0.1	-0.6	-0.6	-0.1	-0.9	-0.6	-0.7
Maternal smoking around birth	0.3	0.4	2.1	1.5	-0.0	0.3	0.6	-0.5	-0.2	0.0
Chronic bronchitis/emphysema (father)	0.3	0.3	1.2	1.1	0.2	0.6	-0.6	-0.5	-0.1	-0.3
Leg predicted mass (left)	0.3	1.8	9.5	-0.4	-0.5	1.5	-3.1	0.1	0.2	-0.5
Nervous feelings	0.3	0.5	2.0	1.4	0.4	0.7	0.3	0.3	0.6	0.4
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.9	-0.3	-0.8	-0.4	-0.1	-0.9	-0.8	-0.8
Heart attack	0.3	0.4	0.9	-0.8	0.4	-1.0	0.6	0.6	-0.3	0.1
Medication: Ramipril	0.3	0.4	1.3	-0.2	0.5	1.2	-0.3	0.9	0.4	0.5
Neuroticism score	0.3	0.6	2.0	1.2	-0.2	-0.8	1.4	0.1	-0.1	0.3
Weight	0.3	1.3	4.5	1.0	0.2	1.8	-2.1	0.4	0.5	-0.1
Number of live births	0.3	0.5	1.1	-0.5	-0.8	-1.0	-0.4	-0.3	-1.0	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.2	1.0	-0.1	1.1	-0.4	0.3	0.3	0.1
Pulse wave Arterial Stiffness index	0.3	0.3	1.4	-0.3	-0.5	-1.2	0.1	-0.3	-0.4	-0.4
Exposure to tobacco smoke at home	0.3	0.3	1.0	0.7	0.4	1.0	0.5	0.0	0.4	0.3
Shortness of breath walking on level ground	0.3	0.3	0.9	0.8	0.1	-0.9	0.9	-0.1	0.0	0.0
Leg fat-free mass (right)	0.3	1.7	9.7	-0.6	-0.8	1.1	-3.1	-0.1	-0.1	-0.7
Breast cancer (self-reported)	0.3	0.4	0.9	-1.0	0.7	0.3	0.1	0.3	0.7	0.6
Osteoporosis (self-reported)	0.3	0.4	1.3	-0.1	0.3	1.1	-0.9	0.2	0.6	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.4	-1.2	-0.6	0.1	-1.1	-0.7	-0.4	-0.8
Leg predicted mass (right)	0.3	1.7	9.4	-0.5	-0.8	1.1	-3.1	-0.1	-0.0	-0.7
Mother’s age at death	0.3	0.4	0.7	0.2	-0.8	-0.4	-0.6	-0.8	-0.6	-0.7
Average weekly beer plus cider intake	0.3	0.5	0.9	-0.6	1.0	-0.4	-0.0	0.8	0.8	0.6
Risk taking	0.3	0.5	1.7	-0.2	-0.4	-0.5	-0.0	-1.3	-0.7	-0.8
Diastolic blood pressure, automated reading	0.3	1.0	5.0	2.2	0.2	0.1	1.1	0.3	0.5	0.7
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.7	-0.6	0.7	-0.7	0.7	0.8	-0.1	0.3
Breast Cancer	0.2	0.5	1.8	0.8	-0.4	0.9	-1.4	-0.3	-0.3	-0.5
Bipolar Disorder (2011)	0.2	0.2	0.4	0.4	0.4	0.6	-0.5	0.4	0.3	0.2
Neuroticism (2016)	0.2	0.4	0.6	0.6	-0.7	-0.7	0.5	-0.8	-0.4	-0.4
Average weekly spirits intake	0.2	0.2	0.7	0.4	-0.0	-0.8	0.8	-0.2	-0.3	-0.1
Systolic blood pressure, automated reading	0.2	0.5	2.1	0.2	-0.9	-1.4	0.4	-0.3	-0.5	-0.2
Mouth/teeth dental problems	0.2	0.4	1.0	1.0	0.2	-0.5	1.0	0.3	0.2	0.5
Depression (self-reported)	0.2	0.3	1.1	0.6	0.0	-0.5	1.0	0.4	-0.0	0.5
Breastfed as a baby	0.2	0.2	0.9	0.6	0.4	0.1	1.0	0.2	0.2	0.3
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	0.0	-0.4	-0.4	-0.3	-0.5	-0.5	-0.6
Medication: Amlodipine	0.2	0.3	0.8	0.5	0.8	0.9	-0.4	0.3	0.5	0.3
Pulse wave peak to peak time	0.2	0.2	0.8	-0.1	-0.0	0.9	-0.7	-0.2	-0.2	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.9	-0.2	-0.6	-1.0	0.5	-0.3	-0.4	-0.1
Had major operations	0.2	0.2	0.7	0.8	0.4	0.7	0.0	0.1	0.2	0.2
Leg pain on walking	0.2	0.3	1.4	-0.0	-0.2	-1.2	0.6	-0.2	-0.1	-0.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.7	-0.1	-0.3	-0.8	-0.3	-0.5	-0.7	-0.5
Supplements: Vitamin C	0.2	0.3	1.0	-0.5	-0.2	0.6	-1.0	-0.0	0.3	-0.0
Handedness (chirality/laterality): Left-handed	0.2	0.2	1.2	-0.4	0.2	0.2	-1.1	-0.1	-0.0	-0.2
Loneliness, isolation	0.2	0.3	1.2	0.5	-0.2	-0.3	1.1	0.1	0.2	0.3
Mineral and other dietary supplements	0.2	0.3	0.9	-0.3	0.6	0.4	0.3	0.9	0.4	0.6
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.8	0.2	-0.9	-0.1	-0.4	-0.5	-0.7	-0.3
Medication: Lisinopril	0.2	0.2	0.7	0.0	-0.9	-0.6	-0.4	-0.2	-0.4	-0.3
Supplements: Calcium	0.2	0.2	0.6	0.2	0.6	0.8	-0.1	0.1	0.7	0.3
Bipolar Disorder (2018)	0.1	0.1	0.2	-0.5	-0.4	-0.4	-0.0	0.4	0.1	0.1
Major Depression (MDD)	0.1	0.2	0.6	-0.2	-0.8	-0.1	-0.0	-0.3	-0.6	-0.3
Ulcerative Colitis	0.1	0.2	1.1	-1.1	0.0	0.5	-0.0	-0.1	0.0	-0.0
Waist Hip Ratio (WHR)	0.1	0.5	1.4	1.0	0.3	-0.9	1.2	0.2	-0.2	0.3
Systolic Blood Pressure	0.1	0.6	1.1	0.8	-0.2	-1.1	0.9	0.9	0.6	0.8
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.9	-0.0	-0.3	0.0	-1.0	0.3	0.1	-0.2
Father’s age at death	0.1	0.1	0.3	0.1	-0.5	-0.4	0.1	-0.0	-0.3	0.1
Worrier / anxious feelings	0.1	0.1	0.5	0.1	-0.7	-0.4	0.3	-0.1	-0.3	-0.1
Birth weight of first child	0.1	0.1	0.3	-0.1	-0.2	-0.4	0.5	-0.6	-0.3	-0.2
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.5	-0.1	-0.1	-0.7	0.3	-0.6	-0.4	-0.5
Worry too long after embarrassment	0.1	0.1	0.3	0.3	0.5	-0.1	0.6	-0.1	0.4	0.2
Number of children fathered	0.1	0.1	0.5	0.7	0.4	0.1	0.1	0.1	0.1	-0.0
Medication: Omeprazole	0.1	0.1	0.7	-0.1	0.1	0.4	-0.8	-0.0	-0.2	-0.1
Pulse rate, automated reading	0.1	0.2	0.7	0.8	-0.3	-0.2	-0.0	0.5	-0.6	-0.2
Chest pain or discomfort	0.1	0.1	0.4	-0.7	-0.5	-0.1	0.1	0.0	-0.3	0.1
Medication: Aspirin	0.1	0.1	0.3	-0.4	-0.3	0.1	-0.5	-0.4	-0.4	-0.4
Smoking status: Previous	0.1	0.2	0.7	0.0	-0.0	-0.8	0.6	-0.3	-0.1	0.1
Medication: Gliclazide	0.1	0.1	0.3	-0.6	0.4	-0.3	0.4	0.1	0.2	0.2
Commuting to job workplace: Public transport	0.1	0.2	0.5	0.4	-0.2	0.7	-0.0	-0.5	0.0	-0.3
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.4	-0.1	-0.4	-0.6	0.1	-0.2	-0.2	-0.1
Alcohol drinker status: Previous	0.1	0.2	1.0	1.0	0.1	-0.0	0.2	-0.0	-0.2	0.2
Hair Pigment	0.0	0.7	1.7	1.3	-0.4	0.6	-1.0	-1.0	-0.5	-0.4
Angina	0.0	0.0	0.1	0.3	0.1	-0.3	-0.1	0.2	-0.3	-0.1
Vitamin and mineral supplements	0.0	0.0	0.1	-0.3	0.4	-0.1	0.2	0.1	-0.1	-0.0
Tinnitus: Yes, but not now, but have in the past	0.0	0.1	0.2	0.5	-0.2	-0.1	-0.1	-0.2	-0.0	-0.2
Birth weight	0.0	0.1	0.2	-0.2	-0.1	-0.0	-0.1	0.5	0.3	0.5
Angina (self-reported)	0.0	0.1	0.2	0.4	0.2	-0.1	-0.2	0.3	-0.3	-0.0
Medication: Aspirin	0.0	0.0	0.1	-0.2	-0.0	0.2	-0.2	-0.1	-0.1	-0.1

Hub : Genes

NOP58

Models

Trait associations