Hub : Genes

CYP20A1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.147 0.0570 5.6e-05 0.008 NA 0.040 NA 0.041 0.07700 NA 0.00057 NA 0.00047
2 ROSMAP Brain Pre-frontal Cortex 0.044 0.0270 5.7e-03 0.004 0.013 0.018 0.017 0.009 0.09700 0.0079 0.00190 0.0028 0.02100
3 TCGA Lung Squamous Cell Carcinoma 0.197 0.0861 1.8e-04 0.028 0.021 0.031 NA 0.019 0.00033 0.0016 0.00016 NA 0.00280

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.5 0.8 1.6 -0.2 0.9 1.3
Bipolar Disorder or Schizophrenia 0.2 0.4 1.1 1.0 -0.2 0.1
Depressed Affect (Nagel 2018) 1.9 3.9 10.4 1.2 0.1 -3.2
Depression (Nagel 2018) 0.8 1.2 2.0 -0.0 1.4 -1.2
Intelligence (Savage-Jansen 2018) 0.2 0.5 1.3 -1.1 0.3 0.3
Neuroticism (Nagel 2018) 1.1 2.7 5.2 1.7 -0.0 -2.3
Schizophrenia (2018) 0.7 1.4 2.3 1.5 -1.0 -0.9
Schizophrenia vs Biploar Disorder 2.3 3.1 9.2 0.1 0.1 -3.0
Worry (Nagel 2018) 1.2 2.6 7.0 2.6 -0.3 -0.9
Alzheimer’s Disease (in mother) 0.6 0.7 1.1 0.0 1.0 -1.0
Alzheimer’s Disease (in father) 8.7 9.5 10.2 -3.2 2.8 -3.2
Alzheimer’s Disease (including proxy) 4.2 6.1 10.0 -2.0 2.1 -3.2
Crohns Disease (2017) 0.7 1.5 3.2 1.0 0.3 1.8
Irritable Bowel Disease (IBD) 0.6 1.5 3.8 1.9 0.5 0.7
Ulcerative Colitis (UC) 0.6 1.1 3.0 1.7 0.5 -0.4
Major Depression (MDD) 2.0 2.4 6.3 -2.5 -0.7 -0.6
Reaction Time 0.6 1.2 1.7 -0.9 -1.0 1.3
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.3 -1.2 0.2 0.2
Breast Cancer 0.4 0.9 2.4 -0.3 0.5 1.5
Ovarian Cancer 1.7 2.2 4.1 0.4 -1.5 2.0
Prostate Cancer 0.4 0.6 1.8 -0.1 -0.2 -1.4
Age at First Birth 1.5 2.2 4.5 1.0 -1.0 2.1
Bipolar Disorder (2011) 1.6 1.6 3.5 -0.1 1.1 1.9
Body Mass Index (BMI) (2010) 2.1 2.9 4.4 -1.8 1.0 -2.1
Coronary Artery Disease (CAD) 12.7 15.2 29.8 3.8 -1.1 5.5
Crohns Disease (2012) 0.1 0.2 0.5 0.4 0.4 0.7
Mean Putamen Volume 0.7 0.8 2.0 -0.2 1.4 -0.7
Fasting Glucose 0.6 0.7 1.0 -1.0 0.6 -0.9
HbA1C 0.1 0.1 0.2 -0.5 0.2 0.1
HDL Cholesterol 0.2 0.3 0.8 0.9 0.3 -0.1
LDL Cholesterol 2.2 3.4 7.0 0.0 2.6 -1.8
Lupus 0.8 1.3 3.4 -0.2 0.5 -1.9
Neuroticism (2016) 0.8 1.2 2.2 -1.2 -0.2 -1.5
Primary Biliary Cirrhosis 0.5 0.7 1.3 -0.8 -0.4 -1.1
Rheumatoid Arthritis 1.8 2.5 5.3 1.2 2.3 -0.8
Schizophrenia (2014) 0.9 2.0 3.6 1.9 -1.4 -0.7
Triglycerides 1.8 3.0 4.1 -2.0 1.2 -1.8
Type 2 Diabetes (T2D) (2012) 3.0 3.4 8.0 -0.3 1.5 -2.8
Ulcerative Colitis 0.6 0.8 1.2 1.1 0.8 -0.8
Blood Eosinophil Count 1.3 10.3 13.2 -2.2 3.6 -3.6
Blood Platelet Count 2.8 32.6 64.3 -8.0 4.7 -3.5
Blood Red Count 0.1 1.0 2.0 1.0 -0.0 1.4
Blood White Count 0.8 6.2 15.6 0.2 4.0 -1.7
Heel T-Score 2.0 15.6 34.0 3.5 -5.8 0.7
BMI 2.2 13.0 20.2 -4.5 2.6 -3.5
Height 0.8 15.8 24.9 5.0 -0.6 4.7
Waist Hip Ratio (WHR) 0.3 1.2 2.6 -1.6 1.0 -0.1
Systolic Blood Pressure 2.3 11.5 16.3 4.0 -2.3 3.6
Smoking Status 1.2 2.9 3.7 -1.5 1.7 -1.9
Allergy or Eczema 1.5 4.0 11.0 -0.2 1.0 -3.3
Cardiovascular Disease 0.3 1.0 1.6 -1.3 1.1 -0.5
Hypothyroidism (self reported) 0.6 1.3 3.4 0.2 1.9 0.7
Respiratory disease 6.3 14.1 22.7 -1.5 4.2 -4.8
Type 2 Diabetes (T2D) (2018) 0.7 1.2 2.5 -1.0 0.4 -1.6
Lung FEV1/FVC ratio 2.4 12.0 23.6 -4.9 1.5 -3.2
Lung FVC 1.9 9.5 11.0 3.2 -2.7 3.3
Neuroticism 2.1 5.0 10.3 2.2 -0.1 -3.2
Chronotype (morning person) 0.1 0.3 0.5 -0.7 -0.5 0.4
Hair Pigment 0.1 3.2 9.5 -3.1 0.0 -0.5
Tanning 0.2 2.4 5.0 2.2 0.9 -1.2
Hand grip strength (left) 0.4 1.2 3.0 1.7 0.0 0.7
Number of treatments/medications taken 1.7 3.0 4.4 -1.4 2.1 -1.6
Average weekly spirits intake 3.1 3.8 7.8 0.3 1.9 -2.8
Sensitivity / hurt feelings 0.7 1.2 2.5 1.6 0.0 -1.0
Frequency of depressed mood in last 2 weeks 2.0 2.8 7.1 -1.1 0.3 -2.7
Hearing difficulty/problems: Yes 0.3 0.4 0.9 -0.0 1.0 -0.5
Relative age of first facial hair 2.5 5.1 9.8 2.2 -3.1 -0.9
Other serious medical condition/disability diagnosed by doctor 1.8 2.4 6.7 0.3 2.6 -0.7
Ever used hormone-replacement therapy (HRT) 1.3 1.6 3.6 -1.1 0.5 -1.9
Ever had hysterectomy (womb removed) 1.2 1.4 2.3 0.2 1.4 -1.5
Systolic blood pressure, automated reading 0.7 2.1 3.0 1.3 -1.2 1.7
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.4 -0.7 -0.1 0.4
Angina 3.5 4.6 13.3 0.4 -0.6 3.6
Medication for hormone replacement therapy 4.6 5.1 6.7 -2.6 1.9 -2.3
Vitamin and mineral supplements 2.7 3.7 6.4 2.5 -1.6 1.4
Supplements: Zinc 0.9 1.0 1.1 -1.0 -1.1 0.9
Medication: Co-codamol 0.3 0.4 0.7 0.8 0.5 -0.3
Medication: Metformin 2.0 2.8 3.8 -1.9 1.3 -1.7
Diabetes (father) 1.1 1.4 3.3 1.8 -0.4 0.8
Diabetes (mother) 1.2 1.6 4.1 -0.8 -0.4 -2.0
Severe depression (siblings) 0.3 0.4 0.5 0.7 0.3 0.7
Pack years adult smoking proportion 2.6 3.9 6.6 -2.6 1.1 -2.0
Impedance of leg (right) 0.0 0.1 0.2 0.3 0.4 0.3
Leg fat-free mass (left) 0.1 0.3 0.6 -0.0 0.5 0.8
Trunk fat percentage 1.0 3.9 5.9 -2.4 1.3 -2.1
Hand grip strength (right) 0.6 1.7 4.4 2.1 -0.1 0.9
Townsend deprivation index at recruitment 6.1 8.6 16.8 -4.1 1.5 -2.6
Current tobacco smoking 3.9 6.4 9.8 -2.8 1.3 -3.1
Average weekly fortified wine intake 0.3 0.4 0.8 -0.2 0.5 -0.9
Maternal smoking around birth 1.9 2.7 4.7 -1.9 0.0 -2.2
Fed-up feelings 1.0 1.9 5.6 -0.1 0.2 -2.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.0 2.4 -1.3 1.5 -1.5
Relative age voice broke 1.0 1.5 3.8 0.7 -2.0 -0.4
Taking other prescription medications 3.4 5.3 8.7 -1.6 2.1 -3.0
Age when periods started (menarche) 1.8 4.3 6.8 1.8 -1.7 2.6
Bilateral oophorectomy (both ovaries removed) 0.9 1.1 2.7 -0.6 0.4 -1.7
Heel bone mineral density (BMD) T-score, automated (left) 2.3 5.3 14.3 0.9 -3.8 0.9
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 1.2 -1.0 -1.1 -0.5
Qualifications: CSEs or equivalent 3.3 4.3 6.2 -2.5 -1.5 -2.1
Serious illness, injury or assault to yourself 0.4 0.5 0.8 -0.9 0.5 -0.5
High blood pressure 0.3 0.8 2.2 -0.2 0.3 1.5
Hayfever, allergic rhinitis or eczema 1.4 3.0 8.1 -0.6 0.7 -2.8
Multivitamins +/- minerals 3.7 4.7 10.2 -3.2 0.6 -1.9
Stomach or abdominal pain in last month 5.2 6.4 9.2 -2.9 1.4 -3.0
Supplements: Glucosamine 0.6 0.8 1.9 -0.8 0.1 -1.4
Diverticular disease/diverticulitis (self-reported) 5.5 6.5 11.4 -1.4 2.5 -3.4
Medication: Atenolol 3.4 4.3 11.1 -1.2 -0.6 3.3
Medication: Levothyroxine sodium 0.4 0.8 1.6 -0.1 1.3 0.8
Sitting height 1.3 9.2 16.2 3.3 -0.8 4.0
Chronic bronchitis/emphysema (father) 4.2 4.9 10.0 -3.2 0.5 -2.1
High blood pressure (mother) 0.2 0.3 0.3 -0.6 -0.5 0.4
Body mass index (BMI) 1.8 7.5 14.0 -3.7 1.5 -2.5
Impedance of leg (left) 0.0 0.0 0.1 -0.4 0.1 0.0
Leg predicted mass (left) 0.1 0.3 0.6 -0.1 0.5 0.8
Trunk fat mass 0.8 3.4 5.6 -2.4 1.4 -1.6
Waist circumference 1.8 6.8 10.0 -3.2 2.1 -2.4
Number of incorrect matches in round 0.9 1.5 2.3 0.8 -1.5 1.2
Past tobacco smoking 0.5 0.9 1.8 -1.4 -0.5 0.7
Alcohol usually taken with meals 0.7 1.1 1.9 0.3 1.1 1.4
Nervous feelings 2.0 3.6 8.4 2.9 -1.4 -0.7
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.2 -1.1 0.1 -0.7
Hearing difficulty/problems with background noise 2.5 4.0 5.1 -2.3 1.6 -2.0
Hair/balding pattern: Pattern 2 1.9 2.4 6.2 -2.5 0.8 0.5
Had menopause 0.3 0.3 0.5 -0.1 0.7 -0.7
Had other major operations 0.3 0.4 0.6 -0.7 -0.1 0.8
Forced vital capacity (FVC) 2.6 10.0 18.7 4.3 -1.7 2.9
Heel bone mineral density (BMD) T-score, automated (right) 2.3 5.2 13.0 1.3 -3.6 0.9
Ever unenthusiastic/disinterested for a whole week 2.4 3.0 5.3 -2.3 -1.2 -1.5
Qualifications: None of the above 0.2 0.4 1.1 0.1 -0.4 -1.1
Financial difficulties in last 2 years 2.0 2.7 4.2 -2.0 -0.5 -1.9
Mouth/teeth dental problems 0.8 1.2 3.0 1.7 -0.1 0.8
Heart attack 7.0 8.9 24.9 0.6 -1.2 5.0
Allergy 2.7 6.2 11.0 0.2 -2.8 3.3
Pain all over the body in last month 1.9 2.1 4.0 2.0 1.4 0.5
Diabetes (self-reported) 0.5 0.8 1.5 -0.9 -0.2 -1.2
Hayfever/allergic rhinitis (self-reported) 0.0 0.0 0.1 -0.3 -0.2 -0.1
Medication: Ramipril 0.9 1.1 2.7 -0.7 -0.5 1.6
Medication: Simvastatin 1.2 1.8 4.4 -0.7 2.1 -0.7
Fluid intelligence score 0.6 1.2 1.8 -1.4 1.2 -0.6
Illnesses of siblings 0.2 0.3 0.6 0.8 0.2 0.6
Neuroticism score 1.6 3.3 7.9 1.4 0.0 -2.8
Weight 0.3 1.4 3.0 -1.7 1.0 -0.6
Impedance of arm (right) 0.3 1.6 2.4 1.5 0.3 -1.5
Arm fat percentage (right) 2.4 9.4 13.0 -3.6 1.5 -3.6
Trunk fat-free mass 0.1 0.8 2.1 0.4 0.1 1.4
Hip circumference 1.0 4.2 5.8 -2.4 1.2 -2.3
Time employed in main current job 1.6 1.8 2.9 1.7 0.8 1.4
Alcohol intake versus 10 years previously 0.5 0.7 1.6 -1.2 0.6 -0.5
Father’s age at death 1.3 1.8 2.9 1.7 0.1 -1.5
Worrier / anxious feelings 0.9 1.7 5.1 2.3 -0.3 -0.1
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 0.8 -0.9 0.2 -0.5
Falls in the last year 4.2 5.6 7.3 -2.3 2.7 -2.1
Hair/balding pattern: Pattern 3 2.1 3.1 7.3 1.3 -2.7 0.5
Number of live births 0.1 0.1 0.2 -0.3 -0.3 0.4
Forced expiratory volume in 1-second (FEV1) 1.2 4.2 7.9 2.8 -1.1 1.9
Pulse rate 0.9 1.5 3.0 -1.2 0.2 1.7
Happiness 0.6 0.7 1.3 1.1 -0.4 -0.8
Noisy workplace 2.9 3.5 5.4 -1.9 2.3 -1.2
Qualifications: A levels/AS levels or equivalent 0.8 1.8 5.0 2.2 0.7 -0.0
Serious illness, injury or assault of a close relative in last 2 years 1.4 1.6 2.2 1.0 -1.4 1.5
Mouth/teeth dental problems: Dentures 0.7 1.1 2.1 -1.5 0.2 1.1
Asthma 3.0 5.9 13.2 -0.6 2.0 -3.6
Medication: Ibuprofen (e.g. Nurofen) 2.3 2.9 4.1 -1.8 1.2 -2.0
Medication: Cholesterol lowering 0.3 0.5 1.1 1.1 0.7 0.2
Depression (self-reported) 1.7 2.1 5.0 -1.1 -2.2 -0.2
Medication: Lansoprazole 0.5 0.6 0.9 0.1 0.9 -1.0
Prospective memory result 1.0 1.2 2.2 1.5 0.2 1.2
Lung cancer (father) 3.6 4.2 10.5 -3.2 0.6 -1.3
Illnesses of mother 0.5 0.6 0.8 0.9 -0.2 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.1 5.6 2.4 -0.9 1.8
Pulse wave Arterial Stiffness index 1.0 1.2 2.2 -0.3 -1.1 -1.5
Impedance of arm (left) 0.3 1.5 4.0 2.0 0.0 -0.8
Arm fat mass (right) 1.2 5.1 8.4 -2.9 1.2 -2.4
Trunk predicted mass 0.1 0.7 1.9 0.3 0.1 1.4
Standing height 1.0 9.9 15.8 4.0 -0.9 3.6
Length of working week for main job 0.1 0.1 0.2 -0.4 0.1 0.5
Exposure to tobacco smoke at home 6.5 7.3 10.6 -3.3 2.1 -2.6
Breastfed as a baby 0.2 0.2 0.3 0.1 0.6 0.5
Tense / ‘highly strung’ 0.1 0.1 0.3 0.2 0.0 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 1.7 2.6 4.5 -1.8 0.0 -2.1
Hair/balding pattern: Pattern 4 0.3 0.6 1.0 0.8 0.4 -1.0
Birth weight of first child 0.3 0.6 1.6 -0.0 0.4 -1.3
Peak expiratory flow (PEF) 0.9 2.1 6.0 2.5 0.3 -0.5
Pulse wave reflection index 5.2 6.4 15.2 -1.1 1.7 -3.9
Ever highly irritable/argumentative for 2 days 1.2 1.4 2.6 -0.4 1.6 -1.2
Loud music exposure frequency 0.4 0.4 1.2 0.0 -1.1 -0.0
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.7 0.4 -0.2 1.3
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.7 -0.1 -0.3 -0.8
Blood clot in the leg (DVT) 2.0 2.6 3.6 1.9 1.9 0.8
Medication: Paracetamol 2.4 3.9 6.5 -2.0 1.2 -2.6
Headache pain in last month 6.1 10.5 20.8 -3.0 1.3 -4.6
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 1.3 -1.1 -0.6 -1.0
Glaucoma (self-reported) 0.4 0.4 1.2 0.1 -0.3 1.1
Gout (self-reported) 1.2 1.7 4.4 -2.1 0.0 -0.8
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 1.5 -0.5 1.2 1.1
Medication: Amlodipine 1.3 1.8 4.2 1.1 2.1 0.2
Medication: Ventolin 100micrograms inhaler 2.1 2.7 4.7 -0.1 1.8 -2.2
Birth weight 0.4 0.9 2.3 -1.5 0.5 -0.1
Chronic bronchitis/emphysema (mother) 2.9 3.3 6.8 -2.6 1.1 -1.4
High blood pressure (siblings) 0.3 0.4 0.8 -0.9 -0.5 -0.3
Forced vital capacity (FVC), Best measure 2.3 8.4 15.3 3.9 -1.2 2.9
Body fat percentage 1.6 6.4 10.5 -3.2 1.5 -2.5
Leg fat percentage (right) 3.2 11.8 20.8 -4.6 2.4 -3.0
Arm fat-free mass (right) 0.2 1.3 3.3 -0.7 0.1 1.8
Exposure to tobacco smoke outside home 3.3 4.4 9.8 -3.1 0.9 -1.5
Comparative body size at age 10 0.5 1.4 4.0 2.0 -0.4 0.4
Number of full brothers 0.4 0.5 0.7 -0.6 0.6 -0.8
Worry too long after embarrassment 0.6 1.0 2.2 0.4 0.7 -1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 1.7 2.2 4.9 -1.4 0.1 -2.2
Wheeze or whistling in the chest in last year 5.2 9.2 17.6 -0.8 3.0 -4.2
Number of children fathered 0.2 0.2 0.4 0.1 0.7 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 1.8 -0.2 -1.1 1.4
Age at first live birth 0.4 0.7 1.2 1.1 0.2 0.9
Pulse wave peak to peak time 1.3 1.6 2.8 0.6 1.2 1.7
Health satisfaction 0.3 0.4 0.9 0.4 0.4 -1.0
Shortness of breath walking on level ground 0.1 0.2 0.3 -0.1 0.3 -0.6
Qualifications: College or University degree 0.4 1.2 1.7 1.3 0.8 1.1
Eye problems/disorders: None of the above 2.1 2.5 5.0 1.3 -2.2 -0.8
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.6 0.2 0.7 0.0
Emphysema/chronic bronchitis 2.4 2.7 6.1 -1.2 2.5 -0.8
Medication for pain relief, constipation, heartburn 2.2 3.8 4.9 2.2 -1.4 2.1
Neck or shoulder pain in last month 1.4 2.0 4.0 -1.4 0.4 -2.0
Medication: Blood pressure 2.4 4.2 10.1 1.5 -0.3 3.2
Angina (self-reported) 3.4 4.5 12.7 0.4 -0.7 3.6
Migraine (self-reported) 5.0 6.2 7.6 -2.2 2.5 -2.8
Medication: Ibuprofen 1.7 2.1 3.1 -1.4 1.1 -1.8
Medication: Allopurinol 0.7 0.9 2.4 -1.5 -0.6 0.0
Medication: Omeprazole 0.1 0.2 0.4 0.7 0.3 -0.1
Medication: Seretide 50 evohaler 0.6 0.7 2.1 -0.0 0.2 -1.4
Mean time to correctly identify matches 0.6 1.1 2.1 -0.3 -1.4 1.0
Heart disease (mother) 0.9 1.1 3.2 0.1 -0.4 1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.0 1.0 0.7 -0.8
Whole body fat mass 1.0 4.1 6.9 -2.6 1.5 -1.8
Leg fat mass (right) 2.0 7.7 14.4 -3.8 2.2 -1.9
Arm predicted mass (right) 0.2 1.3 3.6 -0.4 0.0 1.9
Pulse rate, automated reading 1.1 3.5 6.2 -2.5 1.3 1.7
Alcohol intake frequency. 2.9 6.6 15.4 -3.9 0.7 -2.0
Comparative height size at age 10 0.2 1.3 2.4 -0.0 1.5 1.2
Number of full sisters 1.6 2.0 5.4 -0.6 0.4 -2.3
Suffer from ‘nerves’ 0.6 0.9 2.0 -0.2 -0.7 -1.4
Overall health rating 1.3 2.8 4.9 -1.2 2.2 -1.5
Chest pain or discomfort 0.8 1.2 2.2 -0.4 1.5 -1.1
Had major operations 2.2 2.5 6.4 -2.5 -0.9 -0.6
Age at last live birth 1.0 1.5 2.3 1.2 -0.9 1.5
Family relationship satisfaction 0.2 0.3 0.7 -0.1 -0.4 -0.8
Leg pain on walking 0.5 0.6 1.5 0.3 1.2 0.4
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 1.6 -0.8 -0.6 -1.2
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.5 -0.4 0.2 0.7
Illness, injury, bereavement, stress in last 2 years 1.6 1.9 5.0 2.2 0.4 0.8
Medication: Aspirin 0.6 0.7 1.4 -0.1 0.9 1.2
Supplements: Vitamin C 0.5 0.6 1.0 -0.6 1.0 0.6
Knee pain experienced in last month 3.1 4.8 5.9 -2.0 2.1 -2.4
Hypertension (Self-reported) 0.5 1.5 4.1 -0.3 0.4 2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.7 4.3 6.6 -1.1 2.6 -2.3
Illnesses of father: Heart disease 4.7 6.6 17.3 0.8 -1.3 4.2
Illnesses of siblings: Diabetes 1.5 1.9 4.5 0.8 2.1 0.8
Smoking status: Previous 1.1 1.7 4.4 2.1 0.4 0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.9 2.7 1.3 1.2 1.6
Whole body fat-free mass 0.1 0.6 1.7 0.1 0.3 1.3
Leg fat-free mass (right) 0.0 0.2 0.7 -0.0 0.1 0.8
Arm fat percentage (left) 2.1 8.3 11.8 -3.4 1.5 -3.3
Average weekly red wine intake 1.5 2.3 6.4 -0.3 0.6 2.5
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.3 -0.1 0.5 1.1
Mood swings 1.0 1.7 4.1 1.1 -0.1 -2.0
Loneliness, isolation 3.1 4.3 11.0 -1.1 0.7 -3.3
Long-standing illness, disability or infirmity 2.7 4.2 9.1 -1.2 3.0 -1.5
Ever had bowel cancer screening 1.2 1.5 3.8 0.7 -0.3 -1.9
Diabetes diagnosed by doctor 0.4 0.6 1.2 -0.7 0.4 -1.1
Ever had stillbirth, spontaneous miscarriage or termination 1.6 1.7 3.5 -1.2 1.9 -0.3
Friendships satisfaction 1.7 2.1 3.2 1.8 -1.8 -0.2
Qualifications: nursing, teaching 0.8 1.3 2.9 1.7 1.0 0.0
Commuting to job workplace: Walk 0.9 1.0 1.5 -0.9 -1.2 -0.9
Eye problems/disorders: Cataract 1.6 1.8 5.3 -0.3 2.3 0.2
Mouth/teeth dental problems: Mouth ulcers 1.8 2.9 5.8 1.2 1.2 -2.4
Medication for cholesterol 0.9 1.4 3.4 1.9 -0.6 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.1 1.8 -1.4 -0.2 -1.2
Back pain experienced in last month 1.4 2.0 4.3 -1.3 0.3 -2.1
Mineral and other dietary supplements 2.2 3.0 4.9 0.7 -2.2 1.9
Breast cancer (self-reported) 0.3 0.3 0.9 0.3 0.0 0.9
Asthma (self-reported) 2.8 5.5 12.4 -0.8 1.9 -3.5
Osteoporosis (self-reported) 2.4 2.9 3.5 -1.8 1.4 -1.9
Osteoarthritis (self-reported) 3.4 4.4 6.9 -2.2 1.2 -2.6
Medication: Aspirin 0.5 0.6 1.5 -0.2 0.5 1.2
Medication: Gliclazide 0.9 1.1 2.8 -0.4 0.4 -1.7
Illnesses of father: None of the above (group 1) 0.8 1.0 3.0 1.7 -0.2 0.3
Smoking status: Current 3.8 6.1 8.5 -2.7 1.5 -2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 0.9 -0.6 -0.0 -0.9
Whole body water mass 0.1 0.6 1.8 0.1 0.1 1.3
Leg predicted mass (right) 0.0 0.2 0.7 0.1 0.1 0.8
Arm fat mass (left) 1.1 4.6 7.4 -2.7 1.4 -2.1
Number of self-reported non-cancer illnesses 4.8 8.4 12.2 -1.7 3.2 -3.5
Average weekly champagne plus white wine intake 0.9 1.2 2.3 -0.8 1.5 -0.9
Miserableness 2.3 3.9 11.7 0.1 -0.2 -3.4
Guilty feelings 2.6 3.9 10.6 0.1 1.0 -3.3
Wears glasses or contact lenses 1.2 1.3 2.3 -1.5 -0.7 -1.1
Ever taken oral contraceptive pill 1.1 1.2 3.5 0.0 1.9 0.4
Hearing aid user 1.3 1.5 3.5 1.9 0.9 0.5
Mother’s age at death 1.0 1.3 2.9 1.7 -0.9 -0.4
Financial situation satisfaction 0.3 0.4 0.5 -0.7 -0.5 -0.7
Tinnitus: Yes, now most or all of the time 0.8 1.0 2.0 1.4 0.1 1.0
Commuting to job workplace: Public transport 0.9 1.0 2.5 0.5 1.6 -0.6
Eye problems/disorders: Glaucoma 0.7 0.9 1.0 -0.8 -1.0 1.0
Medication: Blood pressure 0.6 1.1 2.6 0.6 -0.6 1.6
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.2 0.4 1.1 -0.2
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.4 -0.0 0.6 -0.6
High cholesterol (Self-reported) 3.4 6.0 10.5 -1.9 1.9 -3.2
Medication: Bendroflumethiazide 0.2 0.3 0.4 0.3 -0.7 0.6
Medication: Paracetamol 1.1 1.7 2.8 -1.7 0.7 -1.4
Medication: Lisinopril 2.0 2.6 5.7 1.4 0.0 2.4
Medication: Atorvastatin 0.7 0.9 2.7 0.2 -0.1 -1.6
Illnesses of father: High blood pressure 2.1 2.6 5.3 -1.5 0.2 -2.3
Alcohol drinker status: Never 1.1 1.4 3.7 -1.9 0.6 -0.2
Ever smoked 0.7 1.2 2.3 0.9 0.7 -1.5
Basal metabolic rate 0.1 0.4 0.9 -0.4 0.4 0.9
Leg fat percentage (left) 3.8 13.7 23.6 -4.9 2.4 -3.4
Arm fat-free mass (left) 0.1 0.7 1.7 -0.6 0.3 1.3
Number of operations (self-reported) 0.1 0.2 0.3 -0.5 0.4 -0.1
Average weekly beer plus cider intake 0.3 0.5 1.3 -0.3 1.1 0.2
Irritability 1.3 2.2 5.0 1.0 -0.9 -2.2
Risk taking 3.6 5.3 11.0 -1.0 3.3 -2.0
Ever had prostate specific antigen (PSA) test 0.8 0.9 1.5 1.2 -0.8 -0.8
Fractured/broken bones in last 5 years 3.4 4.4 9.7 -3.1 1.8 -0.4
Age started oral contraceptive pill 1.7 2.2 4.1 0.0 -1.6 2.0
Diastolic blood pressure, automated reading 1.4 4.2 8.1 -2.0 0.8 -2.8
Ever depressed for a whole week 2.8 3.4 6.2 -1.8 0.9 -2.5
Unable to work because of sickness or disability 0.6 0.8 1.5 -0.2 1.2 0.9
Commuting to job workplace: Cycle 1.6 1.9 2.1 -1.4 -1.4 -1.4
Myopia 1.1 1.6 4.4 2.1 -0.4 -0.6
Vascular/heart problems diagnosed by doctor 0.9 2.5 6.5 0.7 -0.7 -2.5
Cholesterol lowering medication 5.5 8.1 12.6 -3.5 1.7 -3.0
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 0.5 0.3 0.6 -0.7
Pain experienced in last month 2.4 4.0 10.0 0.9 -1.1 3.2
Supplements: Calcium 4.0 4.5 8.4 -1.1 2.9 -2.0
Basal cell carcinoma (self-reported) 0.2 0.2 0.4 0.6 -0.3 -0.5
Heart attack/myocardial infarction (self-reported) 6.3 8.1 22.8 0.5 -1.2 4.8
Deep venous thrombosis (DVT) (self-reported) 1.7 2.2 3.6 1.9 1.5 1.0
Heart disease (siblings) 2.2 2.7 6.3 0.3 -2.5 1.3
Alcohol drinker status: Previous 1.5 1.7 2.8 -1.4 0.6 -1.7
Pack years of smoking 2.7 4.0 7.5 -2.7 1.4 -1.6
Impedance of whole body 0.1 0.4 1.1 1.1 0.1 -0.2
Leg fat mass (left) 2.2 8.6 16.6 -4.1 2.1 -2.2
Arm predicted mass (left) 0.1 0.5 0.9 -0.7 0.4 0.9