[Hub]/) : Traits : Heel T-Score : ← →

chr2:217,456,567-219,903,258

Best TWAS P=1.16e-16 · Best GWAS P=8.16e-30 conditioned to 2.16e-12

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	PNKD	0.12	0.08	lasso	3	0.07	4.2e-06	5.95	-6.0	1.8e-09	-0.04	0.02	0.98	FALSE
2	GTEx	Adipose Subcutaneous	TMBIM1	0.12	0.08	lasso	5	0.10	2.9e-08	6.02	-5.7	1.4e-08	-0.05	0.02	0.98	FALSE
3	GTEx	Adipose Subcutaneous	ARPC2	0.16	0.16	enet	12	0.17	4.4e-14	5.05	-5.5	3.2e-08	-0.03	1.00	0.00	FALSE
4	GTEx	Adipose Subcutaneous	RP11-378A13.1	0.25	0.34	lasso	9	0.37	2.4e-31	5.95	-6.1	1.2e-09	-0.04	0.02	0.98	FALSE
5	GTEx	Adipose Visceral Omentum	RP11-378A13.1	0.30	0.28	enet	30	0.32	2.9e-17	5.85	-5.3	1.5e-07	-0.04	0.03	0.97	FALSE
6	GTEx	Adrenal Gland	PNKD	0.20	0.16	lasso	5	0.19	1.6e-07	5.32	-5.4	6.4e-08	-0.04	0.08	0.90	FALSE
7	GTEx	Adrenal Gland	RP11-378A13.1	0.25	0.22	enet	17	0.30	3.2e-11	5.94	-6.1	1.3e-09	-0.03	0.03	0.97	FALSE
8	GTEx	Artery Aorta	TMBIM1	0.17	0.20	enet	29	0.19	1.2e-10	5.94	-5.4	5.4e-08	-0.03	0.03	0.97	FALSE
9	GTEx	Artery Aorta	RP11-378A13.1	0.28	0.28	enet	20	0.31	2.2e-17	5.79	-5.9	3.2e-09	-0.03	0.04	0.96	FALSE
10	GTEx	Artery Coronary	TMBIM1	0.22	0.08	lasso	1	0.03	3.6e-02	5.92	-5.9	3.2e-09	-0.03	0.03	0.81	FALSE
11	GTEx	Artery Coronary	RP11-378A13.1	0.34	0.36	lasso	8	0.38	1.2e-13	5.94	-6.0	1.5e-09	-0.03	0.03	0.97	FALSE
12	GTEx	Artery Tibial	RP11-378A13.1	0.20	0.17	enet	13	0.24	7.6e-19	5.14	-5.7	1.1e-08	-0.04	0.02	0.98	FALSE
13	GTEx	Brain Caudate basal ganglia	RP11-378A13.1	0.55	0.38	enet	17	0.52	4.0e-17	5.88	-6.1	9.0e-10	-0.03	0.04	0.96	FALSE
14	GTEx	Brain Cerebellar Hemisphere	RP11-378A13.1	0.53	0.57	enet	24	0.60	3.3e-19	5.85	-5.7	1.0e-08	-0.02	0.04	0.96	FALSE
15	GTEx	Brain Cerebellum	RP11-378A13.1	0.46	0.52	enet	15	0.46	2.5e-15	5.79	-6.0	1.4e-09	-0.03	0.04	0.96	FALSE
16	GTEx	Brain Cortex	RP11-378A13.1	0.61	0.56	enet	23	0.61	6.7e-21	5.87	-6.0	2.0e-09	-0.04	0.04	0.96	FALSE
17	GTEx	Brain Frontal Cortex BA9	RP11-378A13.1	0.38	0.54	enet	24	0.49	7.2e-15	5.87	-6.0	2.8e-09	-0.04	0.05	0.95	FALSE
18	GTEx	Brain Hypothalamus	RP11-378A13.1	0.37	0.44	enet	17	0.45	5.6e-12	5.85	-5.7	1.1e-08	-0.03	0.05	0.95	FALSE
19	GTEx	Brain Nucleus accumbens basal ganglia	RP11-378A13.1	0.47	0.51	lasso	5	0.48	1.5e-14	5.87	5.8	6.1e-09	0.04	0.04	0.96	FALSE
20	GTEx	Brain Putamen basal ganglia	RP11-378A13.1	0.35	0.28	enet	18	0.29	1.2e-07	5.87	-5.4	5.5e-08	-0.04	0.03	0.97	FALSE
21	GTEx	Breast Mammary Tissue	RP11-378A13.1	0.27	0.26	enet	20	0.30	1.3e-15	5.95	-6.0	1.7e-09	-0.04	0.02	0.98	FALSE
22	GTEx	Breast Mammary Tissue (Male)	RP11-378A13.1	0.27	0.24	enet	29	0.27	5.4e-07	5.95	-5.2	1.9e-07	-0.04	0.02	0.95	FALSE
23	GTEx	Breast Mammary Tissue (Female)	ARPC2	0.12	-0.01	lasso	5	-0.01	7.1e-01	5.48	-5.7	9.2e-09	-0.04	0.09	0.05	FALSE
24	GTEx	Breast Mammary Tissue (Female)	RP11-378A13.1	0.30	0.11	lasso	10	0.22	3.0e-07	6.02	-5.9	2.9e-09	-0.03	0.02	0.98	FALSE
25	GTEx	Cells EBV-transformed lymphocytes	TMBIM1	0.35	0.24	lasso	10	0.24	2.3e-08	6.03	-5.8	5.7e-09	-0.03	0.02	0.98	FALSE
26	GTEx	Cells EBV-transformed lymphocytes	RP11-378A13.1	0.18	0.14	lasso	6	0.13	4.6e-05	6.00	-6.2	7.8e-10	-0.02	0.03	0.94	FALSE
27	GTEx	Cells Transformed fibroblasts	TMBIM1	0.15	0.25	lasso	3	0.27	2.2e-20	5.97	-6.0	1.8e-09	-0.05	0.02	0.98	FALSE
28	GTEx	Cells Transformed fibroblasts	RP11-378A13.1	0.29	0.26	enet	24	0.31	2.0e-23	6.02	-6.1	1.1e-09	-0.03	0.02	0.98	FALSE
29	GTEx	Colon Sigmoid	RP11-378A13.1	0.31	0.33	enet	23	0.34	6.0e-13	5.68	-5.8	7.1e-09	-0.05	0.04	0.96	FALSE
30	GTEx	Colon Transverse	RP11-378A13.1	0.35	0.31	lasso	6	0.43	4.6e-22	5.94	-6.1	1.3e-09	-0.03	0.02	0.98	FALSE
31	GTEx	Esophagus Gastroesophageal Junction	RP11-378A13.1	0.37	0.37	enet	26	0.33	1.1e-12	5.68	-5.6	2.8e-08	-0.03	0.06	0.94	FALSE
32	GTEx	Esophagus Mucosa	RP11-378A13.1	0.28	0.32	enet	27	0.39	1.3e-27	5.87	-6.1	8.2e-10	-0.03	0.03	0.97	FALSE
33	GTEx	Esophagus Muscularis	RP11-378A13.1	0.37	0.42	enet	21	0.41	6.9e-27	5.87	-6.1	1.3e-09	-0.03	0.05	0.95	FALSE
34	GTEx	Heart Atrial Appendage	TMBIM1	0.11	0.09	lasso	2	0.08	1.8e-04	5.92	-5.8	4.9e-09	-0.04	0.03	0.97	FALSE
35	GTEx	Heart Atrial Appendage	RP11-378A13.1	0.26	0.17	enet	13	0.22	2.0e-10	5.85	-6.0	1.6e-09	-0.04	0.03	0.97	FALSE
36	GTEx	Heart Left Ventricle	TMBIM1	0.12	0.08	enet	11	0.07	1.4e-04	4.97	-6.0	2.3e-09	-0.04	0.05	0.95	FALSE
37	GTEx	Heart Left Ventricle	RP11-378A13.1	0.21	0.16	enet	27	0.19	1.3e-10	5.94	-6.2	4.1e-10	-0.04	0.03	0.97	FALSE
38	GTEx	Lung	PNKD	0.13	0.04	enet	10	0.03	3.7e-03	5.01	-5.9	4.3e-09	-0.03	0.09	0.90	FALSE
39	GTEx	Lung	ARPC2	0.19	0.10	lasso	7	0.09	1.6e-07	5.21	-5.4	5.7e-08	-0.05	1.00	0.00	FALSE
40	GTEx	Lung	RP11-378A13.1	0.27	0.30	enet	19	0.37	2.3e-29	5.97	-6.2	5.2e-10	-0.03	0.03	0.97	FALSE
41	GTEx	Muscle Skeletal	TMBIM1	0.10	0.06	lasso	9	0.06	3.3e-06	6.03	-5.5	4.8e-08	-0.02	0.02	0.98	FALSE
42	GTEx	Muscle Skeletal	ARPC2	0.23	0.17	enet	18	0.20	1.9e-19	5.47	-5.3	1.0e-07	-0.06	1.00	0.00	FALSE
43	GTEx	Muscle Skeletal	RP11-378A13.1	0.19	0.27	enet	23	0.31	1.7e-30	5.87	-6.0	1.4e-09	-0.04	0.04	0.96	FALSE
44	GTEx	Nerve Tibial	RP11-378A13.1	0.33	0.31	enet	35	0.36	1.0e-26	5.73	-5.8	7.2e-09	-0.06	0.05	0.95	FALSE
45	GTEx	Pancreas	RP11-378A13.1	0.29	0.14	enet	24	0.16	4.4e-07	5.85	-5.8	7.1e-09	-0.04	0.04	0.96	FALSE
46	GTEx	Pituitary	PNKD	0.29	0.23	enet	21	0.24	8.9e-07	5.14	-5.2	1.6e-07	0.00	0.07	0.91	TRUE
47	GTEx	Pituitary	TMBIM1	0.20	0.16	enet	13	0.02	8.4e-02	5.87	-6.2	6.3e-10	-0.04	0.04	0.90	FALSE
48	GTEx	Pituitary	RP11-378A13.1	0.64	0.52	enet	19	0.52	2.7e-15	5.85	-5.9	4.7e-09	-0.04	0.03	0.97	FALSE
49	GTEx	Prostate	RP11-378A13.1	0.29	0.12	enet	14	0.10	2.1e-03	5.94	-6.2	4.4e-10	-0.03	0.03	0.90	FALSE
50	GTEx	Skin Not Sun Exposed Suprapubic	PNKD	0.28	0.28	enet	9	0.26	9.7e-15	5.31	-5.8	7.9e-09	-0.04	0.20	0.80	FALSE
51	GTEx	Skin Not Sun Exposed Suprapubic	RP11-378A13.1	0.26	0.25	lasso	8	0.28	5.6e-16	5.32	-5.9	3.0e-09	-0.03	0.03	0.97	FALSE
52	GTEx	Skin Sun Exposed Lower leg	PNKD	0.27	0.29	lasso	8	0.34	3.9e-29	5.32	-5.8	6.4e-09	-0.04	0.10	0.90	FALSE
53	GTEx	Skin Sun Exposed Lower leg	RP11-378A13.1	0.29	0.36	enet	28	0.40	9.8e-35	6.00	-5.9	3.9e-09	-0.04	0.02	0.98	FALSE
54	GTEx	Small Intestine Terminal Ileum	RP11-378A13.1	0.39	0.17	enet	15	0.14	4.5e-04	5.79	-5.7	9.8e-09	-0.05	0.04	0.91	FALSE
55	GTEx	Spleen	RP11-378A13.1	0.37	0.41	enet	27	0.41	1.2e-11	6.00	-6.5	8.4e-11	-0.03	0.02	0.98	FALSE
56	GTEx	Stomach	RP11-378A13.1	0.32	0.32	enet	20	0.34	3.4e-17	6.02	-6.6	3.3e-11	-0.04	0.02	0.98	FALSE
57	GTEx	Testis	PNKD	0.20	0.19	lasso	3	0.19	1.2e-08	5.95	-6.0	2.7e-09	-0.03	0.02	0.98	FALSE
58	GTEx	Testis	TMBIM1	0.27	0.13	enet	20	0.15	2.7e-07	5.31	-5.2	1.5e-07	-0.02	0.03	0.97	FALSE
59	GTEx	Testis	RP11-378A13.1	0.37	0.18	enet	22	0.22	2.7e-10	6.03	-5.9	3.5e-09	-0.04	0.02	0.98	FALSE
60	GTEx	Thyroid	PNKD	0.13	0.12	enet	13	0.14	6.3e-11	5.14	-5.9	3.3e-09	-0.02	0.24	0.76	FALSE
61	GTEx	Thyroid	ARPC2	0.10	0.03	enet	8	0.04	3.0e-04	5.47	-5.1	2.9e-07	-0.06	0.70	0.01	FALSE
62	GTEx	Thyroid	RP11-378A13.1	0.31	0.34	enet	34	0.38	3.7e-30	5.87	-5.8	7.3e-09	-0.03	0.03	0.97	FALSE
63	GTEx	Vagina	RP11-378A13.1	0.22	0.07	enet	11	0.03	7.1e-02	5.87	-5.9	3.4e-09	-0.04	0.05	0.72	FALSE
64	GTEx	Whole Blood	PNKD	0.05	0.04	lasso	3	0.03	4.4e-04	5.87	-6.0	2.2e-09	-0.04	0.06	0.92	FALSE
65	GTEx	Whole Blood	RP11-378A13.1	0.11	0.13	enet	18	0.15	1.6e-13	6.00	-6.0	2.5e-09	-0.03	0.02	0.98	FALSE
66	METSIM	Adipose	PNKD	0.07	0.08	lasso	7	0.08	4.8e-12	5.14	-5.4	7.5e-08	-0.03	0.13	0.87	FALSE
67	METSIM	Adipose	TMBIM1	0.14	0.15	lasso	11	0.14	1.3e-20	6.02	-6.0	1.7e-09	-0.04	0.02	0.98	FALSE
68	METSIM	Adipose	TNS1	0.05	0.00	blup	543	0.01	1.1e-02	0.47	7.4	1.5e-13	0.07	0.07	0.10	TRUE
69	ROSMAP	Brain Pre-frontal Cortex	GPBAR1	0.06	0.05	blup	430	0.05	3.2e-07	3.95	5.8	5.9e-09	0.02	0.36	0.64	FALSE
70	ROSMAP	Brain Pre-frontal Cortex	DIRC3	0.12	0.07	bslmm	697	0.08	2.7e-10	8.37	-8.3	1.2e-16	-0.56	1.00	0.00	TRUE
71	ROSMAP	Brain Pre-frontal Cortex	RP11-378A13.1	0.44	0.64	bslmm	431	0.64	1.1e-107	5.68	-5.5	4.0e-08	-0.03	0.05	0.95	FALSE
72	YFS	Blood	AAMP	0.02	0.02	lasso	3	0.01	4.1e-05	5.24	-5.2	1.6e-07	-0.05	0.40	0.57	FALSE
73	YFS	Blood	GPBAR1	0.04	0.06	lasso	10	0.06	2.3e-18	5.87	5.9	4.3e-09	0.04	0.04	0.96	FALSE
74	The Cancer Genome Atlas	Breast Invasive Carcinoma	DIRC3	0.03	0.01	blup	275	0.01	1.4e-03	-3.24	-5.6	1.7e-08	-0.12	0.65	0.01	TRUE
75	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMBIM1	0.04	0.01	blup	49	0.02	4.8e-05	5.85	-5.6	2.6e-08	-0.01	0.03	0.95	FALSE
76	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMBIM1	0.02	0.01	blup	49	0.02	2.6e-03	6.03	-6.2	4.5e-10	-0.04	0.02	0.93	FALSE
77	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TMBIM1	0.10	0.04	blup	49	0.06	3.0e-03	5.94	-6.1	1.4e-09	-0.05	0.02	0.83	FALSE
78	The Cancer Genome Atlas	Soft Tissue Sarcoma	TMBIM1	0.07	0.04	blup	49	0.03	4.8e-03	5.29	-5.9	3.5e-09	-0.06	0.04	0.60	FALSE
79	The Cancer Genome Atlas	Thyroid Carcinoma	TMBIM1	0.02	0.02	blup	49	0.02	9.3e-03	5.95	-5.9	3.6e-09	-0.05	0.02	0.75	FALSE