[Hub]/) : Traits : Heel T-Score :

chr2:217,456,567-219,903,258

Best TWAS P=1.16e-16 · Best GWAS P=8.16e-30 conditioned to 2.16e-12

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous PNKD 0.12 0.08 lasso 3 0.07 4.2e-06 5.95 -6.0 1.8e-09 -0.04 0.02 0.98 FALSE
2 GTEx Adipose Subcutaneous TMBIM1 0.12 0.08 lasso 5 0.10 2.9e-08 6.02 -5.7 1.4e-08 -0.05 0.02 0.98 FALSE
3 GTEx Adipose Subcutaneous ARPC2 0.16 0.16 enet 12 0.17 4.4e-14 5.05 -5.5 3.2e-08 -0.03 1.00 0.00 FALSE
4 GTEx Adipose Subcutaneous RP11-378A13.1 0.25 0.34 lasso 9 0.37 2.4e-31 5.95 -6.1 1.2e-09 -0.04 0.02 0.98 FALSE
5 GTEx Adipose Visceral Omentum RP11-378A13.1 0.30 0.28 enet 30 0.32 2.9e-17 5.85 -5.3 1.5e-07 -0.04 0.03 0.97 FALSE
6 GTEx Adrenal Gland PNKD 0.20 0.16 lasso 5 0.19 1.6e-07 5.32 -5.4 6.4e-08 -0.04 0.08 0.90 FALSE
7 GTEx Adrenal Gland RP11-378A13.1 0.25 0.22 enet 17 0.30 3.2e-11 5.94 -6.1 1.3e-09 -0.03 0.03 0.97 FALSE
8 GTEx Artery Aorta TMBIM1 0.17 0.20 enet 29 0.19 1.2e-10 5.94 -5.4 5.4e-08 -0.03 0.03 0.97 FALSE
9 GTEx Artery Aorta RP11-378A13.1 0.28 0.28 enet 20 0.31 2.2e-17 5.79 -5.9 3.2e-09 -0.03 0.04 0.96 FALSE
10 GTEx Artery Coronary TMBIM1 0.22 0.08 lasso 1 0.03 3.6e-02 5.92 -5.9 3.2e-09 -0.03 0.03 0.81 FALSE
11 GTEx Artery Coronary RP11-378A13.1 0.34 0.36 lasso 8 0.38 1.2e-13 5.94 -6.0 1.5e-09 -0.03 0.03 0.97 FALSE
12 GTEx Artery Tibial RP11-378A13.1 0.20 0.17 enet 13 0.24 7.6e-19 5.14 -5.7 1.1e-08 -0.04 0.02 0.98 FALSE
13 GTEx Brain Caudate basal ganglia RP11-378A13.1 0.55 0.38 enet 17 0.52 4.0e-17 5.88 -6.1 9.0e-10 -0.03 0.04 0.96 FALSE
14 GTEx Brain Cerebellar Hemisphere RP11-378A13.1 0.53 0.57 enet 24 0.60 3.3e-19 5.85 -5.7 1.0e-08 -0.02 0.04 0.96 FALSE
15 GTEx Brain Cerebellum RP11-378A13.1 0.46 0.52 enet 15 0.46 2.5e-15 5.79 -6.0 1.4e-09 -0.03 0.04 0.96 FALSE
16 GTEx Brain Cortex RP11-378A13.1 0.61 0.56 enet 23 0.61 6.7e-21 5.87 -6.0 2.0e-09 -0.04 0.04 0.96 FALSE
17 GTEx Brain Frontal Cortex BA9 RP11-378A13.1 0.38 0.54 enet 24 0.49 7.2e-15 5.87 -6.0 2.8e-09 -0.04 0.05 0.95 FALSE
18 GTEx Brain Hypothalamus RP11-378A13.1 0.37 0.44 enet 17 0.45 5.6e-12 5.85 -5.7 1.1e-08 -0.03 0.05 0.95 FALSE
19 GTEx Brain Nucleus accumbens basal ganglia RP11-378A13.1 0.47 0.51 lasso 5 0.48 1.5e-14 5.87 5.8 6.1e-09 0.04 0.04 0.96 FALSE
20 GTEx Brain Putamen basal ganglia RP11-378A13.1 0.35 0.28 enet 18 0.29 1.2e-07 5.87 -5.4 5.5e-08 -0.04 0.03 0.97 FALSE
21 GTEx Breast Mammary Tissue RP11-378A13.1 0.27 0.26 enet 20 0.30 1.3e-15 5.95 -6.0 1.7e-09 -0.04 0.02 0.98 FALSE
22 GTEx Breast Mammary Tissue (Male) RP11-378A13.1 0.27 0.24 enet 29 0.27 5.4e-07 5.95 -5.2 1.9e-07 -0.04 0.02 0.95 FALSE
23 GTEx Breast Mammary Tissue (Female) ARPC2 0.12 -0.01 lasso 5 -0.01 7.1e-01 5.48 -5.7 9.2e-09 -0.04 0.09 0.05 FALSE
24 GTEx Breast Mammary Tissue (Female) RP11-378A13.1 0.30 0.11 lasso 10 0.22 3.0e-07 6.02 -5.9 2.9e-09 -0.03 0.02 0.98 FALSE
25 GTEx Cells EBV-transformed lymphocytes TMBIM1 0.35 0.24 lasso 10 0.24 2.3e-08 6.03 -5.8 5.7e-09 -0.03 0.02 0.98 FALSE
26 GTEx Cells EBV-transformed lymphocytes RP11-378A13.1 0.18 0.14 lasso 6 0.13 4.6e-05 6.00 -6.2 7.8e-10 -0.02 0.03 0.94 FALSE
27 GTEx Cells Transformed fibroblasts TMBIM1 0.15 0.25 lasso 3 0.27 2.2e-20 5.97 -6.0 1.8e-09 -0.05 0.02 0.98 FALSE
28 GTEx Cells Transformed fibroblasts RP11-378A13.1 0.29 0.26 enet 24 0.31 2.0e-23 6.02 -6.1 1.1e-09 -0.03 0.02 0.98 FALSE
29 GTEx Colon Sigmoid RP11-378A13.1 0.31 0.33 enet 23 0.34 6.0e-13 5.68 -5.8 7.1e-09 -0.05 0.04 0.96 FALSE
30 GTEx Colon Transverse RP11-378A13.1 0.35 0.31 lasso 6 0.43 4.6e-22 5.94 -6.1 1.3e-09 -0.03 0.02 0.98 FALSE
31 GTEx Esophagus Gastroesophageal Junction RP11-378A13.1 0.37 0.37 enet 26 0.33 1.1e-12 5.68 -5.6 2.8e-08 -0.03 0.06 0.94 FALSE
32 GTEx Esophagus Mucosa RP11-378A13.1 0.28 0.32 enet 27 0.39 1.3e-27 5.87 -6.1 8.2e-10 -0.03 0.03 0.97 FALSE
33 GTEx Esophagus Muscularis RP11-378A13.1 0.37 0.42 enet 21 0.41 6.9e-27 5.87 -6.1 1.3e-09 -0.03 0.05 0.95 FALSE
34 GTEx Heart Atrial Appendage TMBIM1 0.11 0.09 lasso 2 0.08 1.8e-04 5.92 -5.8 4.9e-09 -0.04 0.03 0.97 FALSE
35 GTEx Heart Atrial Appendage RP11-378A13.1 0.26 0.17 enet 13 0.22 2.0e-10 5.85 -6.0 1.6e-09 -0.04 0.03 0.97 FALSE
36 GTEx Heart Left Ventricle TMBIM1 0.12 0.08 enet 11 0.07 1.4e-04 4.97 -6.0 2.3e-09 -0.04 0.05 0.95 FALSE
37 GTEx Heart Left Ventricle RP11-378A13.1 0.21 0.16 enet 27 0.19 1.3e-10 5.94 -6.2 4.1e-10 -0.04 0.03 0.97 FALSE
38 GTEx Lung PNKD 0.13 0.04 enet 10 0.03 3.7e-03 5.01 -5.9 4.3e-09 -0.03 0.09 0.90 FALSE
39 GTEx Lung ARPC2 0.19 0.10 lasso 7 0.09 1.6e-07 5.21 -5.4 5.7e-08 -0.05 1.00 0.00 FALSE
40 GTEx Lung RP11-378A13.1 0.27 0.30 enet 19 0.37 2.3e-29 5.97 -6.2 5.2e-10 -0.03 0.03 0.97 FALSE
41 GTEx Muscle Skeletal TMBIM1 0.10 0.06 lasso 9 0.06 3.3e-06 6.03 -5.5 4.8e-08 -0.02 0.02 0.98 FALSE
42 GTEx Muscle Skeletal ARPC2 0.23 0.17 enet 18 0.20 1.9e-19 5.47 -5.3 1.0e-07 -0.06 1.00 0.00 FALSE
43 GTEx Muscle Skeletal RP11-378A13.1 0.19 0.27 enet 23 0.31 1.7e-30 5.87 -6.0 1.4e-09 -0.04 0.04 0.96 FALSE
44 GTEx Nerve Tibial RP11-378A13.1 0.33 0.31 enet 35 0.36 1.0e-26 5.73 -5.8 7.2e-09 -0.06 0.05 0.95 FALSE
45 GTEx Pancreas RP11-378A13.1 0.29 0.14 enet 24 0.16 4.4e-07 5.85 -5.8 7.1e-09 -0.04 0.04 0.96 FALSE
46 GTEx Pituitary PNKD 0.29 0.23 enet 21 0.24 8.9e-07 5.14 -5.2 1.6e-07 0.00 0.07 0.91 TRUE
47 GTEx Pituitary TMBIM1 0.20 0.16 enet 13 0.02 8.4e-02 5.87 -6.2 6.3e-10 -0.04 0.04 0.90 FALSE
48 GTEx Pituitary RP11-378A13.1 0.64 0.52 enet 19 0.52 2.7e-15 5.85 -5.9 4.7e-09 -0.04 0.03 0.97 FALSE
49 GTEx Prostate RP11-378A13.1 0.29 0.12 enet 14 0.10 2.1e-03 5.94 -6.2 4.4e-10 -0.03 0.03 0.90 FALSE
50 GTEx Skin Not Sun Exposed Suprapubic PNKD 0.28 0.28 enet 9 0.26 9.7e-15 5.31 -5.8 7.9e-09 -0.04 0.20 0.80 FALSE
51 GTEx Skin Not Sun Exposed Suprapubic RP11-378A13.1 0.26 0.25 lasso 8 0.28 5.6e-16 5.32 -5.9 3.0e-09 -0.03 0.03 0.97 FALSE
52 GTEx Skin Sun Exposed Lower leg PNKD 0.27 0.29 lasso 8 0.34 3.9e-29 5.32 -5.8 6.4e-09 -0.04 0.10 0.90 FALSE
53 GTEx Skin Sun Exposed Lower leg RP11-378A13.1 0.29 0.36 enet 28 0.40 9.8e-35 6.00 -5.9 3.9e-09 -0.04 0.02 0.98 FALSE
54 GTEx Small Intestine Terminal Ileum RP11-378A13.1 0.39 0.17 enet 15 0.14 4.5e-04 5.79 -5.7 9.8e-09 -0.05 0.04 0.91 FALSE
55 GTEx Spleen RP11-378A13.1 0.37 0.41 enet 27 0.41 1.2e-11 6.00 -6.5 8.4e-11 -0.03 0.02 0.98 FALSE
56 GTEx Stomach RP11-378A13.1 0.32 0.32 enet 20 0.34 3.4e-17 6.02 -6.6 3.3e-11 -0.04 0.02 0.98 FALSE
57 GTEx Testis PNKD 0.20 0.19 lasso 3 0.19 1.2e-08 5.95 -6.0 2.7e-09 -0.03 0.02 0.98 FALSE
58 GTEx Testis TMBIM1 0.27 0.13 enet 20 0.15 2.7e-07 5.31 -5.2 1.5e-07 -0.02 0.03 0.97 FALSE
59 GTEx Testis RP11-378A13.1 0.37 0.18 enet 22 0.22 2.7e-10 6.03 -5.9 3.5e-09 -0.04 0.02 0.98 FALSE
60 GTEx Thyroid PNKD 0.13 0.12 enet 13 0.14 6.3e-11 5.14 -5.9 3.3e-09 -0.02 0.24 0.76 FALSE
61 GTEx Thyroid ARPC2 0.10 0.03 enet 8 0.04 3.0e-04 5.47 -5.1 2.9e-07 -0.06 0.70 0.01 FALSE
62 GTEx Thyroid RP11-378A13.1 0.31 0.34 enet 34 0.38 3.7e-30 5.87 -5.8 7.3e-09 -0.03 0.03 0.97 FALSE
63 GTEx Vagina RP11-378A13.1 0.22 0.07 enet 11 0.03 7.1e-02 5.87 -5.9 3.4e-09 -0.04 0.05 0.72 FALSE
64 GTEx Whole Blood PNKD 0.05 0.04 lasso 3 0.03 4.4e-04 5.87 -6.0 2.2e-09 -0.04 0.06 0.92 FALSE
65 GTEx Whole Blood RP11-378A13.1 0.11 0.13 enet 18 0.15 1.6e-13 6.00 -6.0 2.5e-09 -0.03 0.02 0.98 FALSE
66 METSIM Adipose PNKD 0.07 0.08 lasso 7 0.08 4.8e-12 5.14 -5.4 7.5e-08 -0.03 0.13 0.87 FALSE
67 METSIM Adipose TMBIM1 0.14 0.15 lasso 11 0.14 1.3e-20 6.02 -6.0 1.7e-09 -0.04 0.02 0.98 FALSE
68 METSIM Adipose TNS1 0.05 0.00 blup 543 0.01 1.1e-02 0.47 7.4 1.5e-13 0.07 0.07 0.10 TRUE
69 ROSMAP Brain Pre-frontal Cortex GPBAR1 0.06 0.05 blup 430 0.05 3.2e-07 3.95 5.8 5.9e-09 0.02 0.36 0.64 FALSE
70 ROSMAP Brain Pre-frontal Cortex DIRC3 0.12 0.07 bslmm 697 0.08 2.7e-10 8.37 -8.3 1.2e-16 -0.56 1.00 0.00 TRUE
71 ROSMAP Brain Pre-frontal Cortex RP11-378A13.1 0.44 0.64 bslmm 431 0.64 1.1e-107 5.68 -5.5 4.0e-08 -0.03 0.05 0.95 FALSE
72 YFS Blood AAMP 0.02 0.02 lasso 3 0.01 4.1e-05 5.24 -5.2 1.6e-07 -0.05 0.40 0.57 FALSE
73 YFS Blood GPBAR1 0.04 0.06 lasso 10 0.06 2.3e-18 5.87 5.9 4.3e-09 0.04 0.04 0.96 FALSE
74 The Cancer Genome Atlas Breast Invasive Carcinoma DIRC3 0.03 0.01 blup 275 0.01 1.4e-03 -3.24 -5.6 1.7e-08 -0.12 0.65 0.01 TRUE
75 The Cancer Genome Atlas Breast Invasive Carcinoma TMBIM1 0.04 0.01 blup 49 0.02 4.8e-05 5.85 -5.6 2.6e-08 -0.01 0.03 0.95 FALSE
76 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma TMBIM1 0.02 0.01 blup 49 0.02 2.6e-03 6.03 -6.2 4.5e-10 -0.04 0.02 0.93 FALSE
77 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma TMBIM1 0.10 0.04 blup 49 0.06 3.0e-03 5.94 -6.1 1.4e-09 -0.05 0.02 0.83 FALSE
78 The Cancer Genome Atlas Soft Tissue Sarcoma TMBIM1 0.07 0.04 blup 49 0.03 4.8e-03 5.29 -5.9 3.5e-09 -0.06 0.04 0.60 FALSE
79 The Cancer Genome Atlas Thyroid Carcinoma TMBIM1 0.02 0.02 blup 49 0.02 9.3e-03 5.95 -5.9 3.6e-09 -0.05 0.02 0.75 FALSE