Hub : Genes

PDE6D

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Liver	0.2150	0.0770	3.3e-03	0.097	NA	0.054	NA	0.089	1.2e-03	NA	1.3e-02	NA	1.8e-03
2	GTEx	Testis	0.2750	0.0910	3.3e-03	0.052	NA	0.053	NA	0.062	2.4e-03	NA	2.2e-03	NA	1.0e-03
3	YFS	Blood	0.0289	0.0097	1.9e-06	0.027	0.016	0.023	0.02	0.024	2.4e-09	2.8e-06	2.7e-08	3.2e-07	2.5e-08
4	TCGA	Glioblastoma Multiforme	0.3240	0.1370	9.8e-04	0.154	0.064	0.141	NA	0.107	2.0e-05	5.2e-03	4.6e-05	NA	3.9e-04
5	TCGA	Brain Lower Grade Glioma	0.0713	0.0379	6.9e-05	0.036	0.037	0.053	NA	0.051	5.0e-05	4.6e-05	1.2e-06	NA	1.6e-06
6	TCGA	Pheochromocytoma and Paraganglioma	0.0810	0.0550	5.3e-03	0.024	0.065	-0.005	NA	0.018	3.8e-02	1.5e-03	5.5e-01	NA	6.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.5	2.3	6.2	-0.8	2.5	1.4	1.4	1.8	-0.5
Bipolar Disorder or Schizophrenia	1.6	3.9	6.4	-2.2	2.0	1.9	1.7	2.5	-1.3
Depressed Affect (Nagel 2018)	5.0	10.6	17.7	-0.0	-3.5	-4.2	-2.9	-3.9	3.1
Depression (Nagel 2018)	0.2	0.3	1.7	-0.0	-1.3	-0.3	0.2	0.0	0.0
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.2	0.5	-0.1	-1.1	-0.8	-0.8	1.1
Neuroticism (Nagel 2018)	2.2	5.2	7.2	-1.2	-2.3	-2.6	-2.7	-2.6	2.0
Schizophrenia (2018)	1.0	2.1	4.9	-2.2	0.6	1.3	1.1	1.8	-1.3
Schizophrenia vs Biploar Disorder	0.3	0.4	2.1	0.0	-1.4	0.0	0.0	0.2	-0.3
Worry (Nagel 2018)	0.5	1.1	5.9	-2.4	-0.3	0.3	-0.3	0.4	-0.7
Alzheimer’s Disease (in mother)	0.8	1.0	3.1	0.1	-1.8	-0.5	-1.2	-1.0	0.1
Alzheimer’s Disease (in father)	0.6	0.6	1.6	-0.7	-0.7	-1.3	0.3	-0.7	0.6
Alzheimer’s Disease (including proxy)	1.2	1.8	4.8	0.1	-2.2	-1.6	-0.5	-1.5	0.7
Crohns Disease (2017)	0.0	0.1	0.3	0.6	0.2	-0.2	-0.1	0.1	0.3
Irritable Bowel Disease (IBD)	0.3	0.7	1.1	0.8	0.7	0.9	1.0	1.0	-0.6
Ulcerative Colitis (UC)	0.8	1.6	2.8	0.8	1.0	1.7	1.6	1.2	-1.1
Major Depression (MDD)	0.8	1.0	3.5	-1.4	-1.9	-0.0	0.0	-0.6	-0.4
Reaction Time	0.4	0.7	1.5	-1.2	-1.0	-0.3	1.0	-0.6	-0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.2	0.6	0.6	-0.7	-0.4	0.2	1.1
Breast Cancer	0.6	1.5	4.3	2.1	0.4	-0.3	-1.8	-0.4	1.1
Ovarian Cancer	0.3	0.4	1.0	-0.8	-0.4	-0.6	-0.3	-1.0	0.6
Prostate Cancer	0.1	0.1	0.4	0.6	0.3	0.5	0.2	-0.1	0.2
Age at First Birth	0.2	0.3	0.8	-0.2	0.6	0.4	0.3	-0.9	-0.3
Bipolar Disorder (2011)	0.4	0.4	2.0	1.4	-0.2	0.6	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.7	2.3	4.7	1.8	0.3	-2.2	-0.3	-1.3	2.0
Coronary Artery Disease (CAD)	1.3	1.6	2.9	-1.5	-1.7	-0.6	-1.3	-1.3	0.5
Crohns Disease (2012)	0.8	1.3	3.8	0.3	0.1	1.0	2.0	1.2	-1.3
Mean Putamen Volume	0.3	0.3	0.9	-0.9	0.7	-0.4	0.2	-0.6	0.4
Fasting Glucose	0.3	0.4	1.7	0.2	-0.2	0.2	1.3	-0.3	-0.6
HbA1C	1.4	1.5	3.2	-1.2	-1.7	-1.1	0.1	-1.8	0.5
HDL Cholesterol	1.0	1.7	4.5	0.3	0.3	1.5	2.1	0.8	-1.6
LDL Cholesterol	0.7	1.2	3.1	0.1	-0.2	-1.0	-1.8	-0.8	1.5
Lupus	1.6	2.5	11.2	-1.0	3.4	0.5	1.2	-0.8	0.3
Neuroticism (2016)	0.1	0.1	0.2	-0.2	-0.4	0.1	-0.0	0.4	-0.3
Primary Biliary Cirrhosis	0.3	0.4	1.1	-1.0	1.1	-0.1	0.2	-0.1	0.4
Rheumatoid Arthritis	1.4	1.9	4.9	0.7	0.7	2.2	-0.1	1.6	-1.8
Schizophrenia (2014)	0.8	1.7	3.0	-1.3	0.9	1.4	1.0	1.7	-1.3
Triglycerides	0.4	0.7	2.0	0.4	1.4	-0.9	-0.5	-0.3	0.9
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	0.7	-0.4	-0.4	-0.5	0.1	-0.4
Ulcerative Colitis	0.5	0.7	2.8	0.5	0.3	0.5	1.7	0.7	-0.5
Blood Eosinophil Count	0.4	2.8	4.8	-2.2	1.0	2.1	-0.4	2.1	-1.4
Blood Platelet Count	0.5	6.1	10.7	1.1	1.1	3.1	1.6	3.3	-3.3
Blood Red Count	1.6	15.5	26.0	0.2	2.4	5.0	3.6	4.8	-5.1
Blood White Count	2.2	16.6	38.2	-0.9	1.1	4.7	4.7	4.0	-6.2
Heel T-Score	0.6	5.2	28.3	5.3	-1.5	-0.1	0.2	-0.3	0.4
BMI	1.6	9.1	18.3	2.1	-0.5	-3.8	-3.6	-2.0	4.3
Height	5.8	110.9	524.4	-22.9	-0.2	8.1	0.9	4.2	-7.5
Waist Hip Ratio (WHR)	0.4	1.6	9.5	-3.1	0.0	0.1	-0.2	0.3	-0.3
Systolic Blood Pressure	1.4	6.9	11.3	1.0	2.5	3.4	2.8	2.7	-2.9
Smoking Status	0.7	1.7	3.6	0.5	-0.8	-1.2	-1.9	-1.3	1.4
Allergy or Eczema	0.6	1.6	4.9	-0.7	2.2	1.3	-0.5	1.2	-1.0
Cardiovascular Disease	0.4	1.2	3.5	1.3	0.4	-0.6	-1.9	-0.9	0.8
Hypothyroidism (self reported)	0.3	0.7	1.4	-0.8	1.2	-0.9	-0.7	-0.4	0.8
Respiratory disease	0.3	0.6	3.1	-0.3	-1.8	0.2	0.1	-0.1	-0.4
Type 2 Diabetes (T2D) (2018)	0.5	0.9	3.5	-1.2	1.9	0.0	0.7	0.2	-0.1
Lung FEV1/FVC ratio	0.2	0.8	2.7	-1.0	1.6	-0.7	-0.2	-0.6	0.4
Lung FVC	0.9	4.7	20.4	4.5	0.4	1.9	0.8	1.0	-1.6
Neuroticism	1.3	3.1	4.6	-1.0	-1.7	-2.1	-1.7	-2.1	1.6
Chronotype (morning person)	0.6	1.4	3.1	-0.8	-0.5	-0.4	-1.8	-1.7	1.2
Hair Pigment	0.4	10.0	17.5	-1.9	2.5	4.2	2.9	3.3	-3.7
Tanning	0.1	0.9	1.9	1.0	-0.1	1.4	0.4	1.2	-0.8
Hand grip strength (left)	1.7	4.4	12.6	-1.4	-0.1	2.3	2.1	1.4	-3.5
Number of treatments/medications taken	0.3	0.5	1.8	-0.0	-1.3	-0.4	-0.6	-0.6	0.3
Average weekly spirits intake	0.7	0.9	2.6	-0.3	1.5	0.3	0.1	1.6	0.4
Sensitivity / hurt feelings	0.5	0.8	3.2	-1.8	-0.5	-0.0	-1.1	0.2	0.2
Frequency of depressed mood in last 2 weeks	0.9	1.3	3.0	-1.1	-1.3	-1.7	-0.2	-1.0	1.1
Hearing difficulty/problems: Yes	0.4	0.5	2.2	-0.5	0.8	0.1	0.4	1.5	0.1
Relative age of first facial hair	0.3	0.6	1.4	-0.1	0.6	1.2	0.4	0.7	-1.1
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	5.4	-2.3	-0.9	-1.3	-1.4	-0.9	0.1
Ever used hormone-replacement therapy (HRT)	1.3	1.7	5.0	2.2	-0.2	-0.8	-1.3	-1.2	1.3
Ever had hysterectomy (womb removed)	2.0	2.2	3.3	1.5	1.1	1.7	1.4	1.8	-1.3
Systolic blood pressure, automated reading	1.0	3.0	7.2	0.4	2.7	1.4	2.0	2.1	-0.6
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.4	-0.5	0.4	-0.6	0.5	-0.6	0.6
Angina	0.4	0.5	1.0	0.4	-0.8	-1.0	0.5	-0.8	0.1
Medication for hormone replacement therapy	0.7	0.8	4.2	-2.1	-0.6	0.2	-0.4	0.1	-0.2
Vitamin and mineral supplements	0.5	0.6	1.6	1.2	-1.1	-0.9	-0.4	-0.2	0.2
Supplements: Zinc	0.5	0.5	1.4	0.8	0.9	0.0	-0.6	-1.2	-0.1
Medication: Co-codamol	1.7	2.0	4.0	2.0	-1.2	-1.4	0.5	-1.8	1.1
Medication: Metformin	0.8	1.1	4.3	-0.3	0.8	0.6	2.1	0.1	-1.2
Diabetes (father)	0.9	1.2	3.9	1.2	0.4	1.0	2.0	-0.1	-0.8
Diabetes (mother)	0.2	0.3	0.7	-0.8	-0.4	-0.0	-0.8	0.2	-0.5
Severe depression (siblings)	1.3	1.5	3.7	-1.9	-0.5	0.9	-0.0	1.2	-1.6
Pack years adult smoking proportion	0.5	0.7	1.8	0.8	0.6	-0.9	-0.8	0.4	1.3
Impedance of leg (right)	0.3	1.2	3.6	-1.9	0.5	1.0	-0.4	0.0	-1.5
Leg fat-free mass (left)	1.1	6.0	34.2	-5.8	-0.7	0.9	-0.2	0.7	-0.5
Trunk fat percentage	2.4	9.7	17.8	-1.5	-0.5	-3.6	-4.2	-2.6	4.2
Hand grip strength (right)	1.4	3.9	11.2	-1.6	0.3	2.5	1.5	1.1	-3.3
Townsend deprivation index at recruitment	0.3	0.5	1.0	-1.0	-1.0	-0.7	-0.2	-0.4	0.4
Current tobacco smoking	0.4	0.7	1.7	0.5	-0.5	-1.3	-1.1	-0.1	0.9
Average weekly fortified wine intake	0.4	0.5	1.0	1.0	0.5	-0.5	0.5	-0.8	0.7
Maternal smoking around birth	1.2	1.7	3.5	-0.7	1.0	-1.6	-1.3	-1.0	1.9
Fed-up feelings	3.4	6.3	12.9	0.3	-3.0	-3.6	-1.6	-2.5	2.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.4	0.2	-1.2	-0.4	0.4	0.1	-0.3
Relative age voice broke	0.3	0.4	1.0	1.0	0.7	0.1	0.9	0.5	-0.0
Taking other prescription medications	0.4	0.6	3.1	-0.2	-1.8	-0.3	-0.5	-0.3	-0.3
Age when periods started (menarche)	1.5	3.5	7.8	0.7	0.5	-2.8	-0.5	-2.6	2.3
Bilateral oophorectomy (both ovaries removed)	3.4	4.0	6.5	0.8	2.6	2.4	1.8	2.1	-1.7
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	5.2	-0.1	0.5	2.3	2.0	1.8	-2.2
Tinnitus: Yes, but not now, but have in the past	0.0	0.1	0.2	-0.4	-0.2	0.2	0.2	-0.2	-0.2
Qualifications: CSEs or equivalent	1.8	2.4	5.8	-1.2	-2.0	-1.4	-0.5	-2.4	0.9
Serious illness, injury or assault to yourself	0.7	0.9	2.9	0.0	-1.7	-0.3	1.1	0.2	-0.9
High blood pressure	0.3	0.8	3.7	0.6	1.9	0.4	-0.4	0.5	0.5
Hayfever, allergic rhinitis or eczema	0.5	1.0	2.1	0.1	1.5	1.2	-1.1	0.5	-1.0
Multivitamins +/- minerals	0.7	0.9	1.9	-1.4	0.9	1.2	0.8	-0.1	-0.8
Stomach or abdominal pain in last month	4.3	5.4	16.7	1.4	0.6	2.1	4.1	1.6	-2.6
Supplements: Glucosamine	0.6	0.8	2.1	-1.4	0.7	0.7	-1.3	-0.0	0.6
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	3.1	0.7	-1.8	-0.6	-0.6	0.2	0.4
Medication: Atenolol	3.7	4.7	9.7	0.8	-0.4	-3.1	-2.0	-2.5	2.7
Medication: Levothyroxine sodium	1.0	1.7	3.2	-1.1	-0.2	-1.4	-1.8	-1.6	0.9
Sitting height	2.0	14.1	50.1	-7.1	-1.1	3.8	0.7	2.5	-3.5
Chronic bronchitis/emphysema (father)	0.8	0.9	1.8	0.4	-1.3	-1.1	-0.4	-1.2	0.7
High blood pressure (mother)	0.8	1.1	4.9	2.2	0.9	0.1	-0.2	0.5	0.5
Body mass index (BMI)	1.8	7.8	19.4	1.6	-0.0	-3.8	-2.6	-1.9	4.4
Impedance of leg (left)	0.3	1.3	5.1	-2.3	0.0	0.5	-0.9	-0.7	-1.1
Leg predicted mass (left)	1.1	6.1	34.3	-5.9	-0.7	0.9	-0.2	0.7	-0.5
Trunk fat mass	1.9	8.3	13.6	-3.7	-0.6	-2.7	-3.7	-2.0	3.3
Waist circumference	2.1	7.8	15.2	-2.5	-0.3	-3.1	-3.5	-1.9	3.9
Number of incorrect matches in round	0.3	0.5	1.3	-0.5	-0.2	1.1	0.7	0.4	-1.0
Past tobacco smoking	1.2	2.1	3.6	-0.5	0.6	1.6	1.6	1.9	-1.9
Alcohol usually taken with meals	0.3	0.4	0.8	-0.9	-0.5	-0.4	-0.6	-0.9	0.4
Nervous feelings	0.8	1.5	5.0	-2.2	-1.4	0.4	0.6	-0.2	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.6	-0.7	-0.0	-1.2	-1.3	-1.1	1.1
Hearing difficulty/problems with background noise	0.4	0.7	2.5	0.0	-1.6	-0.8	-0.6	-0.8	0.2
Hair/balding pattern: Pattern 2	1.3	1.6	5.0	-2.2	-0.9	0.5	0.4	-0.9	-1.6
Had menopause	0.1	0.1	0.5	-0.2	-0.2	-0.0	-0.7	-0.0	0.2
Had other major operations	0.3	0.3	0.7	-0.8	-0.3	-0.4	0.5	-0.7	-0.5
Forced vital capacity (FVC)	1.4	5.4	11.4	-3.4	-0.9	2.6	1.0	1.4	-3.2
Heel bone mineral density (BMD) T-score, automated (right)	2.3	5.3	10.6	0.9	0.2	3.0	2.8	2.0	-3.3
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	1.1	0.6	-0.8	-1.0	-0.0	0.1	0.7
Qualifications: None of the above	0.8	1.8	3.2	0.1	-0.4	-1.5	-1.8	-1.7	1.5
Financial difficulties in last 2 years	0.5	0.7	2.2	1.5	-0.6	-0.6	0.7	-0.7	0.3
Mouth/teeth dental problems	0.2	0.3	0.9	1.0	0.4	0.4	-0.2	0.2	-0.4
Heart attack	0.3	0.4	1.1	1.0	0.8	-0.5	-0.3	0.4	0.6
Allergy	0.2	0.5	1.1	-0.2	-0.3	-1.1	1.0	0.1	0.8
Pain all over the body in last month	0.2	0.2	0.4	-0.6	0.1	0.5	-0.1	0.3	-0.7
Diabetes (self-reported)	0.4	0.6	2.4	-0.2	0.3	0.6	1.5	0.2	-0.9
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	3.1	-0.5	-0.6	0.4	-1.8	0.4	-0.1
Medication: Ramipril	0.7	0.9	1.4	-1.1	1.2	0.4	0.8	1.1	-0.7
Medication: Simvastatin	0.6	0.9	2.5	0.1	-0.2	-1.1	-1.6	-0.8	1.1
Fluid intelligence score	0.2	0.5	2.0	1.4	0.3	-0.6	0.0	0.3	0.6
Illnesses of siblings	0.3	0.5	1.9	-1.4	0.4	0.5	0.4	-0.2	-0.7
Neuroticism score	1.5	3.1	5.8	-0.6	-1.7	-2.2	-1.4	-2.4	1.6
Weight	1.4	6.7	28.1	-5.3	-0.7	-1.3	-2.3	-0.9	1.9
Impedance of arm (right)	0.1	0.6	1.5	-0.8	0.5	1.2	-0.2	-0.1	-1.1
Arm fat percentage (right)	1.9	7.5	17.5	1.1	0.2	-3.5	-2.9	-2.2	4.2
Trunk fat-free mass	2.2	12.9	66.6	-8.2	-0.6	2.1	0.5	1.4	-1.9
Hip circumference	1.5	6.3	12.6	-1.7	-0.5	-2.6	-3.3	-2.0	3.5
Time employed in main current job	0.4	0.4	1.0	1.0	0.1	0.7	0.1	0.6	-0.8
Alcohol intake versus 10 years previously	1.0	1.5	3.0	-0.4	1.4	1.3	1.7	0.7	-1.2
Father’s age at death	1.1	1.5	4.7	1.2	0.7	0.7	2.2	0.0	-1.3
Worrier / anxious feelings	0.1	0.2	0.5	-0.5	0.2	0.2	-0.7	-0.1	-0.5
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.0	5.4	-0.3	-1.2	-2.0	0.2	-2.3	1.1
Falls in the last year	0.4	0.6	2.2	-0.3	-0.4	-0.1	-1.5	-0.6	0.8
Hair/balding pattern: Pattern 3	0.6	1.0	2.4	1.2	0.9	-0.9	-0.3	-0.5	1.5
Number of live births	0.2	0.3	0.9	0.8	0.1	0.9	0.2	0.4	-0.4
Forced expiratory volume in 1-second (FEV1)	1.4	4.7	10.9	-2.6	-0.6	2.5	1.5	1.3	-3.3
Pulse rate	0.8	1.4	3.6	1.2	-1.9	-0.7	-0.6	-1.6	0.4
Happiness	0.5	0.6	1.8	0.2	-0.4	0.6	0.9	-0.5	-1.3
Noisy workplace	0.2	0.2	0.4	-0.2	0.5	0.0	0.6	0.7	-0.2
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.9	-0.2	-0.6	1.0	1.2	0.5	-1.4
Serious illness, injury or assault of a close relative in last 2 years	1.7	2.0	5.6	0.4	-0.4	1.7	1.8	0.3	-2.4
Mouth/teeth dental problems: Dentures	0.5	0.8	2.5	-0.7	0.1	-1.6	-0.1	-0.1	1.4
Asthma	0.4	0.8	3.1	-0.3	-1.8	0.7	0.2	-0.5	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	3.7	0.2	0.2	0.4	1.9	-0.3	-0.7
Medication: Cholesterol lowering	0.3	0.4	1.4	1.2	0.9	0.2	-0.0	0.5	0.1
Depression (self-reported)	0.9	1.1	2.0	-0.7	1.1	1.4	0.3	1.1	-1.3
Medication: Lansoprazole	0.3	0.4	0.9	0.9	0.4	0.1	0.2	-0.4	-0.9
Prospective memory result	1.1	1.4	3.3	-0.3	-1.1	-1.8	-0.2	-1.6	0.9
Lung cancer (father)	2.7	3.1	8.5	-0.2	-2.4	-1.6	-1.2	-2.9	0.8
Illnesses of mother	0.4	0.5	1.3	-1.2	0.1	0.3	1.0	-0.3	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.6	7.7	-2.6	-0.4	2.2	0.7	1.2	-2.8
Pulse wave Arterial Stiffness index	0.3	0.4	0.8	0.9	0.2	0.7	0.6	0.6	-0.3
Impedance of arm (left)	0.2	0.8	2.0	-1.4	-0.2	0.8	-1.0	-0.8	-0.8
Arm fat mass (right)	1.2	4.9	10.6	-1.1	-0.0	-2.6	-2.9	-1.5	3.2
Trunk predicted mass	2.3	13.2	67.4	-8.2	-0.5	2.2	0.5	1.5	-2.0
Standing height	4.9	48.9	225.0	-15.0	-1.1	5.5	0.7	2.6	-5.5
Length of working week for main job	1.7	1.9	5.9	0.8	2.4	1.8	-0.1	1.1	-0.7
Exposure to tobacco smoke at home	1.0	1.1	2.4	0.3	-1.4	-1.4	0.4	-1.6	0.6
Breastfed as a baby	0.5	0.7	2.2	-1.5	0.4	0.4	-0.4	-0.7	-0.9
Tense / ‘highly strung’	1.0	1.6	8.8	-3.0	0.4	0.3	-0.1	-0.2	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.9	-1.7	-1.1	-0.8	0.7	-1.2	-0.7
Hair/balding pattern: Pattern 4	0.8	1.9	7.4	1.0	-0.4	-1.4	0.0	1.1	2.7
Birth weight of first child	0.8	1.5	7.7	-2.8	0.1	0.6	-0.1	0.1	-0.8
Peak expiratory flow (PEF)	0.4	0.9	1.6	-0.7	-1.3	1.2	0.2	0.6	-1.2
Pulse wave reflection index	0.8	1.0	2.2	1.5	1.3	1.1	0.5	0.5	-0.6
Ever highly irritable/argumentative for 2 days	0.4	0.4	0.9	0.8	-0.8	-0.7	-0.0	-0.9	0.0
Loud music exposure frequency	0.7	0.8	2.9	0.3	-1.1	-0.5	1.7	-0.2	-0.2
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	10.5	0.2	0.4	0.8	3.2	0.9	-1.5
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.0	-0.8	-0.7	0.1	-0.9	-1.0	-0.2
Blood clot in the leg (DVT)	0.8	1.0	2.1	0.8	-0.9	-1.4	0.1	-1.4	0.7
Medication: Paracetamol	1.0	1.7	4.7	-0.0	-1.4	1.0	2.2	-0.0	-1.6
Headache pain in last month	1.3	2.2	7.0	-0.9	0.3	1.4	2.6	0.5	-1.8
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	1.9	-1.0	-1.3	0.7	1.4	0.3	-1.4
Glaucoma (self-reported)	0.7	0.8	2.2	-0.8	-1.0	-0.6	-0.7	-1.5	0.2
Gout (self-reported)	0.7	1.0	3.2	0.6	-0.9	-0.6	-1.8	-0.7	0.9
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	3.6	-0.4	-0.3	-1.9	-1.3	-1.7	1.5
Medication: Amlodipine	1.0	1.3	2.8	1.7	0.7	-1.2	-0.5	-1.0	1.5
Medication: Ventolin 100micrograms inhaler	1.7	2.2	8.0	-0.1	-2.8	-0.9	-1.5	-1.2	0.7
Birth weight	0.5	1.1	4.5	-2.1	-1.2	-0.5	-0.5	-0.5	0.2
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.9	-0.1	0.6	-1.0	-0.1	0.0	0.9
High blood pressure (siblings)	0.4	0.5	1.4	1.2	-0.6	-0.6	-0.7	0.1	0.7
Forced vital capacity (FVC), Best measure	1.3	4.8	12.3	-3.5	-1.1	2.3	0.5	1.2	-2.9
Body fat percentage	2.4	9.4	18.7	-0.8	-0.3	-3.8	-4.0	-2.6	4.3
Leg fat percentage (right)	1.7	6.1	14.5	0.1	0.4	-3.2	-2.9	-1.8	3.8
Arm fat-free mass (right)	1.9	9.6	54.6	-7.4	-1.1	0.7	-0.7	0.3	-0.7
Exposure to tobacco smoke outside home	0.0	0.1	0.2	-0.3	0.2	-0.1	-0.1	-0.4	0.3
Comparative body size at age 10	2.8	7.9	15.4	2.1	-1.0	-3.5	-3.2	-2.0	3.9
Number of full brothers	0.4	0.5	1.3	-1.1	-1.0	-0.8	0.3	-0.3	0.5
Worry too long after embarrassment	1.2	2.0	5.8	1.0	-0.2	-0.6	-2.4	-1.5	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.1	-0.2	-1.0	-0.5	-0.7	-0.4	-0.5
Wheeze or whistling in the chest in last year	0.5	0.8	2.2	-0.7	-0.3	1.1	0.3	1.5	-0.9
Number of children fathered	1.2	1.4	2.6	-0.3	0.4	1.4	1.1	1.6	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.3	-1.1	0.0	0.3	1.1	0.3	-0.7
Age at first live birth	0.4	0.6	1.1	-0.5	0.4	1.0	0.8	0.8	-1.1
Pulse wave peak to peak time	0.8	0.9	4.2	-2.1	-0.4	-0.4	-0.8	-0.5	0.0
Health satisfaction	0.7	0.9	1.2	1.1	-0.7	-1.1	-0.9	-0.9	0.8
Shortness of breath walking on level ground	2.0	2.4	6.1	-0.4	-0.6	-2.0	-1.5	-1.3	2.5
Qualifications: College or University degree	0.1	0.4	1.0	-1.0	-1.0	0.2	-0.2	-0.1	-0.8
Eye problems/disorders: None of the above	0.4	0.5	1.3	0.5	0.7	0.9	0.4	1.1	-0.4
Mouth/teeth dental problems: Loose teeth	0.8	1.0	3.1	0.1	1.8	-0.2	-1.2	-0.3	1.1
Emphysema/chronic bronchitis	2.0	2.3	6.8	-1.0	2.6	1.1	-0.1	2.1	-0.3
Medication for pain relief, constipation, heartburn	0.8	1.4	3.5	-0.2	1.9	-0.5	-1.5	0.2	1.4
Neck or shoulder pain in last month	1.0	1.4	4.0	-1.5	0.6	1.2	0.5	-0.0	-2.0
Medication: Blood pressure	0.5	1.0	1.7	-0.1	1.1	-0.9	-1.1	-0.8	1.3
Angina (self-reported)	0.3	0.4	1.1	0.1	-0.6	-1.1	0.3	-0.7	0.2
Migraine (self-reported)	0.3	0.4	1.9	0.1	0.1	-0.3	0.4	-0.6	1.4
Medication: Ibuprofen	0.4	0.5	2.4	0.2	-0.3	-0.1	1.5	-0.7	-0.3
Medication: Allopurinol	0.5	0.7	1.8	0.1	-0.2	-0.5	-1.4	-0.8	1.2
Medication: Omeprazole	2.3	2.7	3.6	-1.9	0.2	1.9	1.5	1.9	-1.8
Medication: Seretide 50 evohaler	0.3	0.4	1.4	-0.5	-0.2	-0.3	-1.2	0.1	0.7
Mean time to correctly identify matches	0.4	0.8	3.2	-1.8	-0.2	0.3	1.1	0.2	-0.5
Heart disease (mother)	0.6	0.8	2.0	1.0	0.5	0.2	1.4	1.1	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	3.1	1.1	-1.5	-0.9	-1.8	-1.0	1.2
Whole body fat mass	1.7	7.0	11.6	-2.7	-0.4	-2.8	-3.4	-1.9	3.4
Leg fat mass (right)	1.2	4.6	8.5	-1.9	0.1	-2.5	-2.8	-1.4	2.9
Arm predicted mass (right)	1.9	9.9	56.2	-7.5	-1.2	0.8	-0.7	0.5	-0.8
Pulse rate, automated reading	0.8	2.7	5.4	-0.2	-0.8	2.3	1.8	1.2	-2.3
Alcohol intake frequency.	0.6	1.4	5.6	-1.2	2.4	0.7	0.6	0.7	-0.1
Comparative height size at age 10	5.2	28.4	127.7	-11.3	-1.4	4.5	0.1	1.4	-4.3
Number of full sisters	0.7	0.9	3.3	-0.5	-1.2	0.6	0.5	0.3	-1.8
Suffer from ‘nerves’	1.1	1.7	4.3	0.2	-1.2	-2.1	-0.2	-1.5	1.4
Overall health rating	0.8	1.8	3.8	-0.0	-0.1	1.1	1.9	1.5	-1.9
Chest pain or discomfort	0.7	1.0	2.8	-1.0	-0.4	0.6	1.2	-0.2	-1.7
Had major operations	1.2	1.4	4.1	2.0	-1.6	-0.5	-1.1	-0.3	0.2
Age at last live birth	1.1	1.6	3.1	-0.1	0.2	1.5	1.6	1.1	-1.8
Family relationship satisfaction	1.1	1.4	3.8	2.0	-1.8	-0.6	0.3	-0.8	0.5
Leg pain on walking	1.1	1.4	3.2	-1.8	-1.1	-1.2	-0.8	-1.2	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.9	-0.6	0.9	-0.0	0.9	0.8	-0.1
Commuting to job workplace: Car/motor vehicle	1.1	1.3	3.2	0.0	1.3	1.8	0.1	1.4	-1.0
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	3.7	-0.6	1.0	-0.2	-1.9	0.6	1.5
Medication: Aspirin	0.1	0.2	0.4	0.4	-0.1	0.6	0.5	0.2	-0.5
Supplements: Vitamin C	0.2	0.2	0.7	-0.9	-0.4	-0.4	-0.2	-0.3	0.4
Knee pain experienced in last month	0.8	1.3	4.3	-2.1	-0.1	-1.1	-0.9	-0.4	1.1
Hypertension (Self-reported)	0.3	0.7	2.8	0.6	1.7	0.6	-0.4	0.7	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.4	5.5	-2.4	-0.6	1.1	2.0	0.7	-1.7
Illnesses of father: Heart disease	1.1	1.5	7.5	-0.1	2.7	0.7	-0.3	1.0	-0.1
Illnesses of siblings: Diabetes	0.7	0.9	2.4	-1.6	1.3	0.9	-0.3	-0.1	-0.5
Smoking status: Previous	1.2	1.9	4.8	0.2	-0.6	-1.4	-1.2	-2.2	1.6
Forced expiratory volume in 1-second (FEV1), predicted	3.2	6.6	34.5	-5.9	-1.1	0.9	-0.9	0.3	-1.4
Whole body fat-free mass	1.8	10.0	55.1	-7.4	-0.7	1.5	0.0	1.0	-1.3
Leg fat-free mass (right)	1.1	6.1	34.7	-5.9	-0.9	0.8	-0.2	0.4	-0.5
Arm fat percentage (left)	2.2	8.9	20.1	0.9	0.0	-3.8	-3.4	-2.6	4.5
Average weekly red wine intake	0.2	0.3	0.7	-0.1	-0.8	0.5	0.7	0.2	-0.8
Handedness (chirality/laterality): Left-handed	1.4	1.7	3.8	-2.0	-0.1	-1.4	-0.5	-1.4	1.5
Mood swings	1.6	2.9	5.1	0.3	-2.3	-2.1	-1.9	-1.9	1.0
Loneliness, isolation	2.2	3.1	6.0	-1.0	-2.4	-2.5	-1.5	-1.5	1.1
Long-standing illness, disability or infirmity	0.8	1.3	5.8	-0.7	-2.4	-0.6	-0.7	-0.7	-0.1
Ever had bowel cancer screening	0.9	1.1	3.1	0.4	1.1	0.9	1.8	0.4	-1.1
Diabetes diagnosed by doctor	0.4	0.7	2.4	-0.4	0.4	0.4	1.6	0.6	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	2.0	0.6	-1.0	-1.0	-0.8	-1.4	0.4
Friendships satisfaction	0.9	1.2	2.9	0.9	-1.4	-1.0	0.3	-1.7	0.5
Qualifications: nursing, teaching	0.2	0.4	1.1	-1.1	-0.2	0.6	0.3	-0.0	-0.7
Commuting to job workplace: Walk	0.8	0.9	2.5	-0.3	-1.6	-0.9	-0.0	-1.3	0.6
Eye problems/disorders: Cataract	0.3	0.3	1.3	0.5	-0.6	-0.5	0.0	-1.1	0.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.3	-0.6	0.2	0.8	-0.5	1.5	0.4
Medication for cholesterol	0.4	0.6	1.8	1.1	0.0	0.3	1.4	0.2	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	1.0	0.4	0.0	0.1	1.0	0.2	-0.5
Back pain experienced in last month	3.6	5.3	10.7	0.6	1.1	2.5	3.3	2.5	-2.6
Mineral and other dietary supplements	0.9	1.2	2.9	1.6	-1.7	-0.5	0.7	-0.8	-0.6
Breast cancer (self-reported)	0.2	0.2	0.3	-0.3	0.5	0.1	0.5	-0.4	-0.6
Asthma (self-reported)	0.4	0.9	3.7	-0.3	-1.9	0.5	0.3	-0.7	-0.7
Osteoporosis (self-reported)	2.4	3.0	6.9	-1.7	1.0	2.0	1.2	1.4	-2.6
Osteoarthritis (self-reported)	1.2	1.5	6.9	-2.6	0.2	0.8	0.7	-0.2	-1.0
Medication: Aspirin	0.1	0.1	0.3	0.5	-0.5	0.1	-0.0	-0.5	0.1
Medication: Gliclazide	0.4	0.4	1.6	1.2	0.1	-0.2	0.9	0.2	0.3
Illnesses of father: None of the above (group 1)	1.1	1.4	3.5	-1.9	-1.8	0.2	-1.1	0.0	-0.5
Smoking status: Current	0.4	0.6	1.5	0.4	-0.5	-1.2	-1.0	-0.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.6	0.8	-0.1	0.4	-0.4	0.3	-0.7
Whole body water mass	1.7	9.9	53.9	-7.3	-0.7	1.5	0.1	1.0	-1.3
Leg predicted mass (right)	1.2	6.2	35.0	-5.9	-0.8	0.8	-0.2	0.4	-0.5
Arm fat mass (left)	1.2	5.0	11.3	-1.4	0.2	-2.6	-2.9	-1.5	3.4
Number of self-reported non-cancer illnesses	0.7	1.2	2.3	-0.0	-1.4	-1.2	-1.5	-1.1	0.8
Average weekly champagne plus white wine intake	0.3	0.5	1.7	0.2	-1.0	-0.1	-1.3	0.1	0.1
Miserableness	5.7	9.9	22.0	0.5	-3.2	-3.7	-2.5	-4.7	2.5
Guilty feelings	3.7	5.6	12.1	0.3	-2.4	-3.0	-1.8	-3.5	1.9
Wears glasses or contact lenses	0.8	0.9	2.4	0.7	0.7	-0.5	-1.6	-0.6	1.2
Ever taken oral contraceptive pill	0.1	0.1	0.5	-0.1	0.4	-0.4	0.7	-0.1	0.3
Hearing aid user	0.4	0.5	1.6	-1.3	0.7	0.2	0.1	0.3	0.9
Mother’s age at death	0.1	0.1	0.2	-0.5	-0.4	0.1	-0.3	-0.1	-0.1
Financial situation satisfaction	0.8	1.0	3.7	1.9	-1.1	-0.4	0.7	-0.5	-0.2
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	-0.4	-0.7	-0.1	-0.5	-0.1	0.4
Commuting to job workplace: Public transport	0.7	0.8	1.5	0.8	-0.7	-1.2	-1.2	-0.6	0.8
Eye problems/disorders: Glaucoma	0.8	1.0	2.6	-0.6	-1.4	-0.7	-0.6	-1.6	-0.1
Medication: Blood pressure	0.2	0.4	1.6	0.5	0.6	0.1	-1.3	0.0	0.6
Pain type(s) experienced in last month: Hip pain	2.9	3.7	6.6	-1.4	0.8	2.5	2.2	1.3	-2.6
Supplements: Fish oil (including cod liver oil)	1.2	1.6	3.6	-1.8	1.9	0.8	0.8	1.2	-0.0
High cholesterol (Self-reported)	0.7	1.3	2.8	0.6	1.7	-0.7	-1.2	-0.1	1.7
Medication: Bendroflumethiazide	1.2	1.8	3.1	0.8	0.4	-1.7	-1.8	-1.1	1.7
Medication: Paracetamol	0.7	1.1	3.3	-0.4	-1.4	0.4	1.8	-0.2	-0.8
Medication: Lisinopril	1.8	2.3	5.5	0.3	-0.5	-1.6	-1.5	-1.8	2.4
Medication: Atorvastatin	2.1	2.6	10.3	1.1	3.2	0.7	-0.5	1.6	0.6
Illnesses of father: High blood pressure	0.4	0.4	2.2	1.5	0.2	-0.3	0.4	-0.1	0.3
Alcohol drinker status: Never	0.1	0.1	0.4	-0.6	-0.3	-0.5	-0.3	-0.2	0.1
Ever smoked	0.8	1.4	2.5	1.2	-0.5	-1.3	-1.1	-1.1	1.6
Basal metabolic rate	1.6	8.6	49.7	-7.0	-0.8	0.8	-0.5	0.6	-0.5
Leg fat percentage (left)	2.0	7.2	16.4	0.0	0.3	-3.5	-3.1	-2.2	4.0
Arm fat-free mass (left)	1.6	8.2	47.0	-6.9	-0.9	0.8	-0.4	0.8	-0.5
Number of operations (self-reported)	1.1	1.6	4.2	2.0	-1.6	-0.8	0.2	-1.5	-0.0
Average weekly beer plus cider intake	0.5	0.7	1.9	-0.0	-1.4	-1.1	-0.1	-0.6	0.6
Irritability	1.6	2.8	5.5	-0.0	0.3	-2.2	-1.5	-2.4	2.1
Risk taking	1.0	1.5	2.5	0.4	-1.1	-1.5	-1.6	-1.2	1.1
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.0	-0.0	0.5	-0.5	-1.4	-0.5	1.1
Fractured/broken bones in last 5 years	0.4	0.5	1.0	0.3	-1.0	-0.8	0.6	-0.5	0.8
Age started oral contraceptive pill	1.5	1.9	4.1	1.3	0.4	-1.3	-1.8	-0.5	2.0
Diastolic blood pressure, automated reading	1.4	4.4	6.0	1.6	2.0	2.4	2.3	1.9	-2.2
Ever depressed for a whole week	0.8	1.0	4.1	-0.3	0.3	0.7	2.0	0.9	-0.6
Unable to work because of sickness or disability	0.3	0.4	0.7	-0.8	0.8	0.1	0.4	0.7	-0.5
Commuting to job workplace: Cycle	0.5	0.6	1.0	-0.6	-1.0	-0.6	-1.0	-0.7	0.4
Myopia	2.4	3.6	8.8	-1.3	2.0	2.1	1.2	3.0	-0.9
Vascular/heart problems diagnosed by doctor	0.2	0.6	2.5	-0.7	-1.6	0.1	0.3	-0.3	-0.8
Cholesterol lowering medication	0.8	1.2	2.6	0.3	0.1	-1.4	-1.6	-0.8	1.3
Medication: Omeprazole (e.g. Zanprol)	2.7	3.3	6.4	-1.2	-0.2	2.3	1.7	2.0	-2.5
Pain experienced in last month	4.5	7.5	13.5	1.2	-1.8	-3.1	-3.7	-2.3	3.4
Supplements: Calcium	1.0	1.1	2.3	-0.6	0.2	1.5	1.4	0.4	-1.4
Basal cell carcinoma (self-reported)	1.0	1.2	3.4	0.4	-1.6	0.9	0.1	-0.2	-1.9
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.4	1.2	0.9	-0.4	-0.2	0.4	0.6
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.2	1.1	-0.6	-1.4	-0.4	-1.5	1.0
Heart disease (siblings)	1.2	1.5	4.8	1.0	0.6	-1.1	-1.1	0.5	2.2
Alcohol drinker status: Previous	0.2	0.3	0.6	-0.3	0.8	-0.0	0.1	0.8	0.4
Pack years of smoking	0.7	1.1	3.5	0.7	0.5	-1.2	-1.0	0.1	1.9
Impedance of whole body	0.2	1.2	4.1	-2.0	-0.3	0.8	-1.0	-0.7	-1.1
Leg fat mass (left)	1.4	5.3	9.7	-1.9	-0.0	-2.6	-3.0	-1.6	3.1
Arm predicted mass (left)	1.6	8.2	46.8	-6.8	-0.9	0.8	-0.5	0.7	-0.6