Best TWAS P=6.33e-21 · Best GWAS P=4.1e-31 conditioned to 3.55e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ATG7 | 0.07 | 0.07 | lasso | 3 | 0.07 | 3.3e-09 | 6.69 | -7.2 | 8.7e-13 | -0.68 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | VGLL4 | 0.04 | 0.02 | blup | 511 | 0.02 | 7.8e-04 | 6.14 | 7.5 | 5.0e-14 | 0.74 | 0.22 | 0.64 | FALSE |
| 3 | GTEx | Brain Hypothalamus | ATG7 | 0.25 | -0.01 | enet | 34 | -0.01 | 5.6e-01 | 0.79 | -5.3 | 9.0e-08 | -0.40 | 0.06 | 0.35 | FALSE |
| 4 | GTEx | Esophagus Mucosa | ATG7 | 0.12 | 0.04 | enet | 10 | 0.05 | 2.2e-04 | -2.78 | 6.2 | 6.4e-10 | 0.47 | 0.31 | 0.49 | FALSE |
| 5 | GTEx | Esophagus Muscularis | MKRN2 | 0.15 | 0.05 | lasso | 8 | 0.12 | 8.9e-08 | -5.02 | 5.2 | 2.2e-07 | 0.02 | 0.97 | 0.00 | FALSE |
| 6 | GTEx | Muscle Skeletal | ATG7 | 0.06 | 0.02 | lasso | 4 | 0.03 | 8.6e-04 | 5.94 | -6.3 | 3.0e-10 | -0.62 | 0.62 | 0.06 | FALSE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | ATG7 | 0.10 | 0.06 | enet | 12 | 0.04 | 2.1e-03 | 8.82 | 8.1 | 6.7e-16 | 0.67 | 0.05 | 0.87 | FALSE |
| 8 | GTEx | Spleen | VGLL4 | 0.34 | -0.01 | enet | 30 | 0.02 | 9.9e-02 | 11.15 | 9.4 | 6.3e-21 | 0.63 | 0.03 | 0.47 | TRUE |
| 9 | GTEx | Testis | VGLL4 | 0.18 | -0.01 | lasso | 3 | -0.01 | 6.9e-01 | 6.69 | 5.4 | 8.3e-08 | 0.53 | 0.06 | 0.16 | FALSE |
| 10 | GTEx | Thyroid | ATG7 | 0.11 | 0.02 | lasso | 3 | 0.02 | 1.1e-02 | -2.78 | 7.5 | 7.0e-14 | 0.55 | 0.12 | 0.48 | FALSE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | VGLL4 | 0.05 | 0.03 | blup | 422 | 0.04 | 3.7e-06 | 10.33 | 9.0 | 2.6e-19 | 0.78 | 0.08 | 0.92 | TRUE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | ATG7 | 0.06 | 0.05 | lasso | 3 | 0.04 | 2.4e-06 | 8.81 | -8.2 | 2.7e-16 | -0.66 | 0.77 | 0.21 | FALSE |
| 13 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ATG7 | 0.05 | 0.05 | lasso | 4 | 0.03 | 3.2e-04 | 8.26 | -5.7 | 1.4e-08 | -0.50 | 0.49 | 0.02 | FALSE |
| 14 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RAF1 | 0.03 | 0.02 | blup | 59 | 0.02 | 1.6e-03 | 5.29 | -6.5 | 8.7e-11 | 0.03 | 0.01 | 0.96 | TRUE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MKRN2 | 0.04 | 0.01 | blup | 51 | 0.02 | 5.3e-03 | 1.78 | 5.1 | 2.9e-07 | 0.00 | 0.06 | 0.48 | FALSE |
| 16 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | RAF1 | 0.31 | 0.16 | lasso | 4 | 0.16 | 3.8e-06 | -5.81 | -5.5 | 2.9e-08 | -0.01 | 0.01 | 0.98 | FALSE |