[Hub]/) : Traits : Hypothyroidism (self reported) :

chr8:132,897,005-134,846,363

Best TWAS P=1.96e-15 · Best GWAS P=3.17e-16 conditioned to 0.00149

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex TG 0.15 0.08 bslmm 886 0.09 4.0e-11 7.7 7.1 1.2e-12 0.52 0.07 0.93 TRUE
2 GTEx Heart Left Ventricle LRRC6 0.18 0.10 enet 15 0.11 2.3e-06 4.7 -5.5 4.1e-08 -0.51 0.99 0.00 FALSE
3 METSIM Adipose TG 0.22 0.26 enet 27 0.27 5.8e-41 -6.9 7.0 3.1e-12 0.53 0.98 0.02 FALSE
4 ROSMAP Brain Pre-frontal Cortex TG 0.07 0.01 enet 26 0.04 2.0e-06 7.5 6.1 1.0e-09 0.40 0.25 0.74 FALSE
5 YFS Blood PHF20L1 0.04 0.00 lasso 10 0.01 3.2e-05 -6.8 6.4 1.8e-10 0.44 0.94 0.06 FALSE
6 The Cancer Genome Atlas Breast Invasive Carcinoma TG 0.10 0.07 lasso 7 0.10 1.7e-20 -6.5 6.8 1.4e-11 0.55 1.00 0.00 FALSE
7 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PHF20L1 0.04 0.02 lasso 2 0.01 4.2e-02 -6.8 6.8 1.2e-11 0.48 0.02 0.64 FALSE
8 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TG 0.03 0.00 lasso 8 0.01 1.6e-02 -6.9 7.8 7.0e-15 0.64 0.15 0.47 FALSE
9 The Cancer Genome Atlas Lung Adenocarcinoma TG 0.04 0.00 enet 13 0.00 8.8e-02 -6.9 7.9 2.0e-15 0.63 0.05 0.81 TRUE
10 The Cancer Genome Atlas Prostate Adenocarcinoma TMEM71 0.04 0.00 blup 71 0.01 8.8e-02 4.7 5.2 2.5e-07 0.43 0.03 0.10 FALSE