Best TWAS P=1.96e-15 · Best GWAS P=3.17e-16 conditioned to 0.00149
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TG | 0.15 | 0.08 | bslmm | 886 | 0.09 | 4.0e-11 | 7.7 | 7.1 | 1.2e-12 | 0.52 | 0.07 | 0.93 | TRUE |
| 2 | GTEx | Heart Left Ventricle | LRRC6 | 0.18 | 0.10 | enet | 15 | 0.11 | 2.3e-06 | 4.7 | -5.5 | 4.1e-08 | -0.51 | 0.99 | 0.00 | FALSE |
| 3 | METSIM | Adipose | TG | 0.22 | 0.26 | enet | 27 | 0.27 | 5.8e-41 | -6.9 | 7.0 | 3.1e-12 | 0.53 | 0.98 | 0.02 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | TG | 0.07 | 0.01 | enet | 26 | 0.04 | 2.0e-06 | 7.5 | 6.1 | 1.0e-09 | 0.40 | 0.25 | 0.74 | FALSE |
| 5 | YFS | Blood | PHF20L1 | 0.04 | 0.00 | lasso | 10 | 0.01 | 3.2e-05 | -6.8 | 6.4 | 1.8e-10 | 0.44 | 0.94 | 0.06 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TG | 0.10 | 0.07 | lasso | 7 | 0.10 | 1.7e-20 | -6.5 | 6.8 | 1.4e-11 | 0.55 | 1.00 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PHF20L1 | 0.04 | 0.02 | lasso | 2 | 0.01 | 4.2e-02 | -6.8 | 6.8 | 1.2e-11 | 0.48 | 0.02 | 0.64 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TG | 0.03 | 0.00 | lasso | 8 | 0.01 | 1.6e-02 | -6.9 | 7.8 | 7.0e-15 | 0.64 | 0.15 | 0.47 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | TG | 0.04 | 0.00 | enet | 13 | 0.00 | 8.8e-02 | -6.9 | 7.9 | 2.0e-15 | 0.63 | 0.05 | 0.81 | TRUE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TMEM71 | 0.04 | 0.00 | blup | 71 | 0.01 | 8.8e-02 | 4.7 | 5.2 | 2.5e-07 | 0.43 | 0.03 | 0.10 | FALSE |