Hub : Genes

LRRC8A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0510 0.0190 0.00085 0.043 0.033 0.039 0.036 0.041 5.4e-06 6.3e-05 1.2e-05 3.1e-05 7.6e-06
2 TCGA Brain Lower Grade Glioma 0.0302 0.0144 0.00028 0.019 0.029 0.024 NA 0.022 3.0e-03 2.6e-04 8.3e-04 NA 1.3e-03
3 TCGA Stomach Adenocarcinoma 0.0500 0.0260 0.00160 0.058 0.049 0.035 NA 0.049 5.2e-05 1.8e-04 1.3e-03 NA 1.8e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.1 0.1 0.2 0.4 0.2 -0.2
Bipolar Disorder or Schizophrenia 1.3 3.1 4.7 2.2 1.6 -1.5
Depressed Affect (Nagel 2018) 0.1 0.1 0.2 -0.0 -0.4 0.5
Depression (Nagel 2018) 0.5 0.8 1.3 1.1 0.6 -0.9
Intelligence (Savage-Jansen 2018) 0.1 0.3 0.5 0.3 0.6 -0.7
Neuroticism (Nagel 2018) 0.1 0.2 0.2 0.5 -0.4 0.2
Schizophrenia (2018) 2.0 4.1 5.9 2.4 1.9 -1.8
Schizophrenia vs Biploar Disorder 1.5 2.0 2.8 1.7 1.2 -1.3
Worry (Nagel 2018) 0.2 0.4 0.8 -0.3 -0.9 0.6
Alzheimer’s Disease (in mother) 0.4 0.4 0.9 -0.5 -0.4 0.9
Alzheimer’s Disease (in father) 0.5 0.6 0.8 -0.9 -0.4 0.8
Alzheimer’s Disease (including proxy) 0.5 0.8 1.1 -1.0 -0.6 1.0
Crohns Disease (2017) 1.5 3.3 4.5 -1.3 -2.1 1.9
Irritable Bowel Disease (IBD) 0.9 2.1 3.2 -0.8 -1.8 1.6
Ulcerative Colitis (UC) 0.3 0.6 1.0 -0.1 -1.0 0.8
Major Depression (MDD) 1.9 2.3 2.7 1.5 1.6 -1.4
Reaction Time 1.7 3.2 5.3 2.3 1.5 -1.3
Verbal and Numeric Reasoning (VNR) 0.8 1.8 3.2 -1.8 -1.2 0.9
Breast Cancer 0.1 0.3 0.5 0.7 0.5 -0.4
Ovarian Cancer 0.1 0.1 0.1 -0.3 -0.4 -0.3
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.2 0.3 0.4 -0.6 -0.5 0.4
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.3 1.7 2.7 1.6 1.1 -1.1
Coronary Artery Disease (CAD) 7.3 8.7 10.2 3.2 2.9 -2.8
Crohns Disease (2012) 1.8 2.9 3.9 -1.4 -2.0 1.7
Mean Putamen Volume 2.3 2.6 3.3 -1.3 -1.7 1.8
Fasting Glucose 0.1 0.1 0.2 -0.4 0.3 -0.2
HbA1C 0.8 0.8 1.1 -1.1 -0.8 0.8
HDL Cholesterol 1.3 2.1 2.8 1.3 1.3 -1.7
LDL Cholesterol 1.0 1.6 2.0 1.2 1.2 -1.4
Lupus 0.1 0.1 0.2 0.4 0.2 -0.2
Neuroticism (2016) 0.2 0.3 0.7 0.8 0.4 0.3
Primary Biliary Cirrhosis 0.0 0.0 0.1 -0.0 -0.3 -0.1
Rheumatoid Arthritis 0.3 0.5 0.6 0.7 0.8 -0.6
Schizophrenia (2014) 2.6 5.8 8.4 2.9 2.2 -2.0
Triglycerides 1.6 2.6 4.0 -1.2 -1.6 2.0
Type 2 Diabetes (T2D) (2012) 0.7 0.8 1.4 0.5 0.8 -1.2
Ulcerative Colitis 0.1 0.1 0.2 -0.2 -0.4 0.2
Blood Eosinophil Count 1.0 7.3 8.5 2.7 2.5 -2.9
Blood Platelet Count 1.4 16.0 20.2 2.9 4.4 -4.5
Blood Red Count 2.1 20.8 21.5 -4.5 -4.6 4.5
Blood White Count 1.8 13.0 14.4 3.2 3.8 -3.8
Heel T-Score 0.4 2.8 4.7 2.2 1.4 -1.3
BMI 0.6 3.3 3.8 1.9 1.8 -1.7
Height 0.4 7.7 9.7 -3.1 -2.5 2.7
Waist Hip Ratio (WHR) 3.2 14.2 15.9 -3.9 -3.3 4.0
Systolic Blood Pressure 0.0 0.2 0.5 -0.7 0.1 -0.5
Smoking Status 0.0 0.1 0.2 0.1 0.1 0.5
Allergy or Eczema 11.6 30.6 33.4 5.8 5.3 -5.5
Cardiovascular Disease 0.5 1.6 2.1 0.9 1.5 -1.4
Hypothyroidism (self reported) 9.7 22.3 27.2 4.5 4.4 -5.2
Respiratory disease 4.0 8.8 12.1 3.5 2.3 -3.0
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.7 -0.0 0.8 -0.6
Lung FEV1/FVC ratio 0.0 0.1 0.3 -0.5 -0.1 0.1
Lung FVC 0.8 3.8 4.5 1.9 1.9 -2.1
Neuroticism 0.2 0.4 1.0 1.0 0.4 -0.3
Chronotype (morning person) 2.4 5.4 6.5 1.9 2.5 -2.5
Hair Pigment 0.3 8.4 9.7 3.1 2.6 -3.0
Tanning 0.0 0.2 0.3 -0.4 -0.6 0.2
Hand grip strength (left) 0.1 0.4 0.5 0.7 0.5 -0.5
Number of treatments/medications taken 0.9 1.6 2.3 1.0 1.5 -1.2
Average weekly spirits intake 0.1 0.1 0.2 0.3 0.5 -0.2
Sensitivity / hurt feelings 0.7 1.1 2.3 1.5 0.7 -0.8
Frequency of depressed mood in last 2 weeks 0.9 1.2 1.9 1.4 1.0 -0.9
Hearing difficulty/problems: Yes 3.7 5.6 6.7 2.3 2.6 -2.2
Relative age of first facial hair 0.5 1.0 1.8 1.4 0.6 -0.8
Other serious medical condition/disability diagnosed by doctor 1.9 2.5 2.7 1.7 1.5 -1.6
Ever used hormone-replacement therapy (HRT) 0.3 0.3 0.5 -0.7 -0.4 0.6
Ever had hysterectomy (womb removed) 2.4 2.7 2.9 -1.7 -1.6 1.6
Systolic blood pressure, automated reading 0.4 1.2 2.0 0.6 1.1 -1.4
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 1.8 0.8 1.1 -1.3
Angina 2.9 3.9 4.3 2.1 1.9 -1.9
Medication for hormone replacement therapy 0.3 0.4 0.6 0.8 0.5 -0.5
Vitamin and mineral supplements 2.0 2.7 3.5 -1.9 -1.6 1.4
Supplements: Zinc 0.7 0.8 1.3 0.6 0.9 -1.1
Medication: Co-codamol 0.2 0.3 0.8 0.1 0.2 -0.9
Medication: Metformin 0.4 0.6 1.2 0.2 1.1 -0.8
Diabetes (father) 2.5 3.1 4.3 -1.3 -1.9 2.1
Diabetes (mother) 0.1 0.1 0.3 0.1 -0.1 0.5
Severe depression (siblings) 0.1 0.1 0.2 0.3 -0.4 0.1
Pack years adult smoking proportion 0.8 1.2 1.4 1.0 1.1 -1.2
Impedance of leg (right) 1.6 7.7 11.4 -3.4 -2.6 2.2
Leg fat-free mass (left) 0.1 0.6 0.8 0.9 0.7 -0.7
Trunk fat percentage 0.0 0.1 0.3 -0.1 0.5 -0.1
Hand grip strength (right) 0.0 0.0 0.0 0.1 0.1 -0.1
Townsend deprivation index at recruitment 0.2 0.3 0.8 -0.1 -0.2 0.9
Current tobacco smoking 1.1 1.9 2.1 -1.3 -1.4 1.4
Average weekly fortified wine intake 7.0 8.2 9.6 3.0 3.1 -2.5
Maternal smoking around birth 0.5 0.7 1.2 0.3 0.9 -1.1
Fed-up feelings 2.0 3.7 4.8 1.9 2.2 -1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 1.4 1.1 1.1 -1.2
Relative age voice broke 0.3 0.4 0.7 0.6 0.2 -0.9
Taking other prescription medications 1.0 1.5 2.0 1.0 1.2 -1.4
Age when periods started (menarche) 0.5 1.1 2.2 -0.7 -1.5 0.8
Bilateral oophorectomy (both ovaries removed) 0.0 0.0 0.0 0.1 0.2 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.0 0.1 0.1 -0.2 -0.4 0.0
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.7 -0.9 -0.5 0.1
Qualifications: CSEs or equivalent 0.3 0.4 0.5 0.7 0.5 -0.6
Serious illness, injury or assault to yourself 0.7 0.8 1.5 0.5 0.8 -1.2
High blood pressure 0.0 0.1 0.2 0.2 0.5 -0.1
Hayfever, allergic rhinitis or eczema 8.4 18.2 20.0 4.5 4.1 -4.2
Multivitamins +/- minerals 2.8 3.6 5.0 2.2 1.8 -1.6
Stomach or abdominal pain in last month 0.1 0.1 0.2 0.2 -0.5 0.2
Supplements: Glucosamine 0.0 0.1 0.1 -0.3 -0.2 -0.2
Diverticular disease/diverticulitis (self-reported) 1.9 2.2 3.2 -0.7 -1.7 1.8
Medication: Atenolol 0.3 0.4 0.5 -0.5 -0.5 0.7
Medication: Levothyroxine sodium 5.7 9.6 11.9 2.8 3.0 -3.5
Sitting height 0.4 2.5 3.2 -1.8 -1.8 1.1
Chronic bronchitis/emphysema (father) 0.1 0.1 0.1 0.3 0.3 0.3
High blood pressure (mother) 1.2 1.7 2.5 1.0 1.2 -1.6
Body mass index (BMI) 1.1 4.5 5.1 2.2 2.3 -1.9
Impedance of leg (left) 1.1 5.5 7.9 -2.8 -2.2 1.9
Leg predicted mass (left) 0.1 0.5 0.7 0.8 0.6 -0.6
Trunk fat mass 0.1 0.4 0.8 0.4 0.9 -0.4
Waist circumference 0.2 0.6 1.1 0.6 1.0 -0.6
Number of incorrect matches in round 0.1 0.2 0.4 0.7 0.2 -0.5
Past tobacco smoking 1.7 3.1 4.4 -2.1 -1.8 1.3
Alcohol usually taken with meals 1.4 2.3 2.8 1.3 1.7 -1.6
Nervous feelings 0.1 0.2 0.2 0.5 0.4 -0.2
Frequency of tenseness / restlessness in last 2 weeks 0.0 0.0 0.0 0.1 0.2 0.2
Hearing difficulty/problems with background noise 5.0 8.0 11.4 3.4 2.8 -2.2
Hair/balding pattern: Pattern 2 0.0 0.0 0.1 -0.1 0.1 -0.3
Had menopause 0.8 1.0 1.2 1.1 1.1 -0.8
Had other major operations 1.5 1.8 2.4 -1.3 -1.5 1.1
Forced vital capacity (FVC) 0.1 0.4 1.1 -0.0 0.4 -1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.1 0.1 0.3 -0.0 -0.4
Ever unenthusiastic/disinterested for a whole week 3.7 4.5 5.2 1.9 2.3 -2.1
Qualifications: None of the above 0.1 0.3 0.5 -0.6 0.1 0.7
Financial difficulties in last 2 years 1.6 2.1 2.9 1.2 1.4 -1.7
Mouth/teeth dental problems 1.3 1.9 3.3 -1.8 -1.3 0.9
Heart attack 0.4 0.5 0.7 0.8 0.6 -0.8
Allergy 8.3 19.0 22.0 -4.7 -4.2 4.2
Pain all over the body in last month 0.4 0.5 0.8 0.5 0.9 -0.6
Diabetes (self-reported) 1.0 1.5 2.3 0.5 1.5 -1.4
Hayfever/allergic rhinitis (self-reported) 5.3 7.0 7.2 2.7 2.6 -2.6
Medication: Ramipril 0.5 0.6 0.7 0.8 0.8 -0.7
Medication: Simvastatin 0.8 1.1 1.5 1.2 0.9 -1.0
Fluid intelligence score 0.6 1.2 1.4 -1.2 -1.1 0.9
Illnesses of siblings 5.0 7.0 8.6 -2.5 -2.9 2.5
Neuroticism score 0.7 1.5 2.5 1.6 1.1 -0.9
Weight 0.3 1.4 1.8 1.1 1.3 -1.0
Impedance of arm (right) 1.7 7.9 9.1 -3.0 -2.9 2.4
Arm fat percentage (right) 0.4 1.5 2.1 1.0 1.5 -1.2
Trunk fat-free mass 0.3 1.7 1.8 1.3 1.3 -1.2
Hip circumference 0.8 3.3 3.5 1.8 1.9 -1.8
Time employed in main current job 1.6 1.8 3.4 -0.6 -1.4 1.8
Alcohol intake versus 10 years previously 0.1 0.2 0.3 0.4 0.3 0.5
Father’s age at death 0.4 0.5 1.1 -0.2 -0.7 1.1
Worrier / anxious feelings 0.5 0.9 1.4 1.2 0.6 -0.9
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.2 0.0 0.4 -0.4
Falls in the last year 6.1 8.2 9.7 3.1 2.7 -2.8
Hair/balding pattern: Pattern 3 0.5 0.8 1.3 -0.2 -1.1 1.1
Number of live births 1.6 2.2 2.7 1.6 1.4 -1.4
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 0.5 -0.5 0.3 -0.7
Pulse rate 0.0 0.1 0.1 -0.3 0.2 0.2
Happiness 0.2 0.3 0.4 -0.5 -0.6 0.4
Noisy workplace 0.9 1.1 1.8 0.9 1.4 -0.9
Qualifications: A levels/AS levels or equivalent 1.0 2.3 3.1 -1.0 -1.8 1.6
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.2 1.8 1.0 0.9 -1.4
Mouth/teeth dental problems: Dentures 1.4 2.4 3.0 1.7 1.7 -1.1
Asthma 3.2 6.3 8.5 2.9 2.1 -2.5
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.3 0.4 0.5 -0.5
Medication: Cholesterol lowering 0.0 0.1 0.1 0.2 0.2 0.3
Depression (self-reported) 0.7 0.8 2.0 -0.1 -1.4 0.7
Medication: Lansoprazole 0.1 0.1 0.1 -0.1 -0.2 0.3
Prospective memory result 0.1 0.1 0.1 0.3 0.3 -0.1
Lung cancer (father) 1.6 1.9 2.0 -1.3 -1.4 1.4
Illnesses of mother 3.0 3.7 4.6 -1.7 -1.9 2.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 0.3 -0.6 0.2 -0.6
Pulse wave Arterial Stiffness index 0.0 0.0 0.1 0.0 0.2 -0.2
Impedance of arm (left) 2.0 9.4 11.0 -3.3 -3.1 2.7
Arm fat mass (right) 0.5 1.9 2.5 1.2 1.6 -1.3
Trunk predicted mass 0.3 1.8 1.9 1.4 1.3 -1.3
Standing height 0.5 4.5 5.0 -2.2 -2.1 2.0
Length of working week for main job 0.4 0.5 0.6 -0.7 -0.8 0.4
Exposure to tobacco smoke at home 1.3 1.5 1.9 0.9 1.4 -1.3
Breastfed as a baby 1.8 2.2 2.5 1.6 1.6 -1.3
Tense / ‘highly strung’ 0.6 1.0 1.7 -0.7 -0.9 1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 2.5 3.8 5.8 1.6 1.7 -2.4
Hair/balding pattern: Pattern 4 0.0 0.0 0.1 0.2 0.1 -0.3
Birth weight of first child 0.6 1.1 1.5 1.0 1.2 -0.9
Peak expiratory flow (PEF) 0.4 0.9 1.3 -1.0 -1.2 0.6
Pulse wave reflection index 2.2 2.7 5.2 1.0 1.4 -2.3
Ever highly irritable/argumentative for 2 days 0.0 0.0 0.1 0.2 0.2 -0.1
Loud music exposure frequency 1.0 1.1 1.7 0.7 1.3 -1.0
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 2.0 -0.9 -1.4 1.1
Mouth/teeth dental problems: Bleeding gums 1.5 2.0 2.9 -1.0 -1.4 1.7
Blood clot in the leg (DVT) 1.9 2.4 4.2 1.3 2.1 -1.1
Medication: Paracetamol 0.7 1.1 1.6 1.3 1.1 -0.7
Headache pain in last month 0.5 0.8 1.5 -0.1 -1.0 1.2
Medication for cholesterol, blood pressure or diabetes 1.1 1.9 2.8 -1.4 -1.7 0.9
Glaucoma (self-reported) 1.1 1.3 1.7 -1.2 -1.3 0.8
Gout (self-reported) 2.4 3.2 4.4 1.5 1.7 -2.1
Hypothyroidism/myxoedema (self-reported) 8.2 16.1 20.2 3.6 3.9 -4.5
Medication: Amlodipine 0.4 0.5 1.4 -0.2 -0.4 1.2
Medication: Ventolin 100micrograms inhaler 0.8 1.0 1.1 1.1 1.0 -0.9
Birth weight 0.0 0.1 0.1 0.2 0.3 0.2
Chronic bronchitis/emphysema (mother) 1.5 1.8 2.1 -1.4 -1.3 1.2
High blood pressure (siblings) 1.0 1.4 1.6 1.3 1.2 -1.1
Forced vital capacity (FVC), Best measure 0.0 0.1 0.3 -0.6 -0.0 -0.4
Body fat percentage 0.1 0.4 0.9 0.3 0.9 -0.6
Leg fat percentage (right) 0.5 1.9 2.9 0.9 1.7 -1.4
Arm fat-free mass (right) 0.3 1.4 1.7 1.2 1.3 -1.0
Exposure to tobacco smoke outside home 0.6 0.9 1.3 0.5 1.0 -1.1
Comparative body size at age 10 0.4 1.2 2.0 1.4 0.8 -0.9
Number of full brothers 0.2 0.2 0.5 -0.3 -0.0 -0.7
Worry too long after embarrassment 0.2 0.3 0.4 0.3 -0.6 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.0 0.0 0.0 0.1 -0.1 -0.1
Wheeze or whistling in the chest in last year 1.6 2.8 4.2 2.1 1.4 -1.4
Number of children fathered 0.9 1.0 1.9 -1.4 -1.0 0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 1.0 -0.6 -1.0 1.0
Age at first live birth 0.1 0.1 0.2 0.3 -0.4 -0.1
Pulse wave peak to peak time 0.1 0.2 0.3 -0.2 -0.5 0.5
Health satisfaction 0.1 0.2 0.3 -0.5 -0.2 0.6
Shortness of breath walking on level ground 0.2 0.2 0.3 0.4 0.6 -0.2
Qualifications: College or University degree 0.7 2.3 3.8 -1.1 -1.9 1.4
Eye problems/disorders: None of the above 0.1 0.1 0.2 -0.2 -0.4 -0.4
Mouth/teeth dental problems: Loose teeth 0.3 0.4 0.7 0.8 0.6 -0.3
Emphysema/chronic bronchitis 0.2 0.3 0.5 0.5 0.2 -0.7
Medication for pain relief, constipation, heartburn 0.8 1.4 2.1 -1.4 -1.3 0.7
Neck or shoulder pain in last month 0.4 0.5 0.7 -0.8 -0.6 0.8
Medication: Blood pressure 0.9 1.6 2.4 1.3 1.6 -0.7
Angina (self-reported) 2.2 2.9 3.2 1.8 1.7 -1.6
Migraine (self-reported) 0.9 1.2 1.9 -0.6 -1.4 1.1
Medication: Ibuprofen 0.2 0.2 0.5 -0.7 -0.4 0.3
Medication: Allopurinol 1.8 2.3 2.8 1.2 1.7 -1.7
Medication: Omeprazole 0.5 0.5 0.8 0.5 0.9 -0.8
Medication: Seretide 50 evohaler 0.6 0.6 1.1 0.7 0.6 -1.1
Mean time to correctly identify matches 0.8 1.5 2.2 1.5 1.2 -0.9
Heart disease (mother) 1.2 1.5 2.2 0.6 1.4 -1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 0.7 0.7 0.8 -0.9
Whole body fat mass 0.2 0.7 1.2 0.6 1.1 -0.7
Leg fat mass (right) 0.5 1.9 2.7 1.1 1.6 -1.3
Arm predicted mass (right) 0.3 1.7 2.0 1.3 1.4 -1.2
Pulse rate, automated reading 0.5 1.8 1.9 -1.2 -1.3 1.4
Alcohol intake frequency. 0.1 0.3 0.7 0.2 0.8 0.1
Comparative height size at age 10 0.1 0.7 1.1 -1.0 -0.5 0.8
Number of full sisters 1.8 2.2 2.4 1.4 1.5 -1.5
Suffer from ‘nerves’ 0.1 0.2 0.3 0.5 0.4 -0.4
Overall health rating 0.2 0.4 0.9 -0.5 -0.1 1.0
Chest pain or discomfort 0.1 0.1 0.3 0.5 0.3 -0.3
Had major operations 1.0 1.2 1.9 1.2 1.4 -0.5
Age at last live birth 0.1 0.1 0.3 0.6 -0.2 -0.3
Family relationship satisfaction 0.0 0.0 0.0 -0.1 0.1 -0.1
Leg pain on walking 2.0 2.5 3.8 1.3 1.9 -1.4
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 1.4 -1.2 -1.0 0.8
Commuting to job workplace: Car/motor vehicle 1.6 1.9 2.7 -1.4 -1.7 1.0
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 0.6 0.7 0.8 -0.5
Medication: Aspirin 2.3 3.0 3.9 1.9 2.0 -1.1
Supplements: Vitamin C 0.7 0.9 1.4 -0.3 -1.1 1.2
Knee pain experienced in last month 4.3 6.7 7.9 -2.8 -2.4 2.5
Hypertension (Self-reported) 0.1 0.2 0.4 0.3 0.6 -0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 0.4 0.7 0.4 -0.6
Illnesses of father: Heart disease 0.3 0.4 0.8 0.5 0.5 -0.9
Illnesses of siblings: Diabetes 0.7 0.8 0.9 0.9 0.9 -0.9
Smoking status: Previous 2.7 4.1 4.7 2.2 2.1 -1.7
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 1.3 -1.1 -1.1 1.0
Whole body fat-free mass 0.3 1.4 1.6 1.3 1.2 -1.1
Leg fat-free mass (right) 0.1 0.6 1.0 1.0 0.7 -0.6
Arm fat percentage (left) 0.3 1.2 1.8 0.9 1.3 -1.0
Average weekly red wine intake 0.1 0.2 0.5 0.3 0.1 -0.7
Handedness (chirality/laterality): Left-handed 0.1 0.2 0.2 0.4 0.1 -0.5
Mood swings 0.1 0.1 0.4 0.1 0.6 -0.1
Loneliness, isolation 0.1 0.1 0.3 0.6 0.2 -0.2
Long-standing illness, disability or infirmity 2.0 3.1 3.3 1.8 1.7 -1.8
Ever had bowel cancer screening 0.2 0.3 0.4 0.6 0.0 0.6
Diabetes diagnosed by doctor 0.6 0.9 1.7 0.2 1.3 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.2 0.1 -0.5 -0.0
Friendships satisfaction 0.9 1.1 1.4 0.8 1.2 -1.1
Qualifications: nursing, teaching 0.5 0.8 1.5 -0.3 -1.2 0.8
Commuting to job workplace: Walk 1.9 2.0 2.3 1.3 1.5 -1.5
Eye problems/disorders: Cataract 0.7 0.8 1.5 0.8 1.2 -0.4
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 1.4 1.1 1.2 -0.9
Medication for cholesterol 0.1 0.1 0.1 0.4 -0.2 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 1.6 1.3 0.9 -0.4
Back pain experienced in last month 1.0 1.5 1.9 -1.4 -1.0 1.3
Mineral and other dietary supplements 0.0 0.0 0.1 0.3 0.1 0.0
Breast cancer (self-reported) 4.0 4.8 6.6 -2.6 -2.2 1.6
Asthma (self-reported) 3.6 7.2 9.9 3.1 2.2 -2.6
Osteoporosis (self-reported) 0.6 0.7 1.6 -1.3 -0.4 0.5
Osteoarthritis (self-reported) 0.5 0.6 1.1 -1.1 -0.7 0.5
Medication: Aspirin 1.9 2.5 3.3 1.7 1.8 -1.1
Medication: Gliclazide 0.2 0.3 0.3 -0.3 -0.6 0.6
Illnesses of father: None of the above (group 1) 0.2 0.2 0.2 0.5 0.4 -0.4
Smoking status: Current 0.9 1.4 1.8 -1.0 -1.2 1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.1 4.4 6.2 1.8 2.5 -2.0
Whole body water mass 0.3 1.7 1.9 1.4 1.3 -1.2
Leg predicted mass (right) 0.1 0.6 1.0 1.0 0.7 -0.6
Arm fat mass (left) 0.4 1.5 2.1 1.0 1.5 -1.1
Number of self-reported non-cancer illnesses 4.8 8.4 10.5 3.2 3.0 -2.4
Average weekly champagne plus white wine intake 0.2 0.2 0.3 -0.5 -0.4 0.5
Miserableness 0.6 1.1 1.4 1.2 1.2 -0.7
Guilty feelings 1.6 2.4 3.5 1.9 1.4 -1.4
Wears glasses or contact lenses 0.3 0.3 0.8 -0.1 0.9 -0.4
Ever taken oral contraceptive pill 1.7 1.9 2.5 0.9 1.5 -1.6
Hearing aid user 2.4 2.7 3.3 1.4 1.7 -1.8
Mother’s age at death 0.2 0.3 0.5 0.7 0.2 -0.5
Financial situation satisfaction 0.5 0.6 0.9 -0.6 -1.0 0.8
Tinnitus: Yes, now most or all of the time 0.6 0.8 1.1 1.0 0.8 -0.8
Commuting to job workplace: Public transport 3.6 4.3 5.3 2.2 2.3 -1.6
Eye problems/disorders: Glaucoma 1.1 1.3 1.9 -1.0 -1.4 0.9
Medication: Blood pressure 0.1 0.2 0.3 -0.5 -0.4 0.1
Pain type(s) experienced in last month: Hip pain 1.0 1.3 1.7 -1.1 -1.0 1.3
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.6 -0.8 -0.5 0.2
High cholesterol (Self-reported) 0.9 1.6 2.3 0.9 1.5 -1.3
Medication: Bendroflumethiazide 0.2 0.3 0.6 -0.7 -0.4 0.5
Medication: Paracetamol 0.2 0.3 0.5 0.7 0.7 -0.3
Medication: Lisinopril 2.0 2.6 3.4 1.5 1.9 -1.4
Medication: Atorvastatin 0.4 0.5 1.0 0.1 1.0 -0.8
Illnesses of father: High blood pressure 0.0 0.0 0.0 -0.1 0.0 -0.2
Alcohol drinker status: Never 0.0 0.1 0.2 -0.0 0.0 0.4
Ever smoked 1.2 2.1 3.4 1.8 1.2 -1.2
Basal metabolic rate 0.2 1.2 1.3 1.1 1.1 -1.0
Leg fat percentage (left) 0.8 2.8 4.0 1.4 2.0 -1.6
Arm fat-free mass (left) 0.5 2.4 2.7 1.6 1.6 -1.4
Number of operations (self-reported) 0.1 0.2 0.3 0.4 0.5 -0.3
Average weekly beer plus cider intake 0.7 1.0 1.8 -0.7 -1.3 0.8
Irritability 0.9 1.5 2.7 1.6 1.0 -1.0
Risk taking 0.5 0.7 1.2 -0.6 -0.7 1.1
Ever had prostate specific antigen (PSA) test 3.0 3.4 6.2 2.5 1.6 -1.3
Fractured/broken bones in last 5 years 1.5 2.0 2.1 -1.5 -1.3 1.5
Age started oral contraceptive pill 1.5 1.9 2.7 1.4 1.6 -1.0
Diastolic blood pressure, automated reading 0.1 0.2 0.3 -0.6 0.0 -0.6
Ever depressed for a whole week 9.5 11.7 12.2 3.5 3.3 -3.5
Unable to work because of sickness or disability 1.2 1.6 2.1 -1.5 -0.9 1.3
Commuting to job workplace: Cycle 5.7 6.9 8.2 2.9 2.6 -2.4
Myopia 0.0 0.0 0.1 -0.1 -0.2 -0.3
Vascular/heart problems diagnosed by doctor 0.1 0.2 0.5 -0.3 -0.7 0.3
Cholesterol lowering medication 1.4 2.0 2.7 0.8 1.6 -1.6
Medication: Omeprazole (e.g. Zanprol) 0.8 0.9 1.4 0.4 1.2 -1.1
Pain experienced in last month 0.8 1.3 1.8 1.0 0.9 -1.4
Supplements: Calcium 0.1 0.1 0.2 -0.4 0.2 -0.2
Basal cell carcinoma (self-reported) 0.6 0.7 1.4 -0.2 -0.9 1.2
Heart attack/myocardial infarction (self-reported) 0.4 0.5 0.7 0.8 0.5 -0.8
Deep venous thrombosis (DVT) (self-reported) 1.1 1.5 2.7 1.0 1.6 -0.8
Heart disease (siblings) 3.2 3.9 5.2 1.7 2.3 -1.9
Alcohol drinker status: Previous 1.4 1.6 2.2 1.4 1.5 -0.8
Pack years of smoking 1.1 1.7 1.8 1.3 1.4 -1.2
Impedance of whole body 1.7 8.7 11.5 -3.4 -2.9 2.5
Leg fat mass (left) 0.5 2.1 2.9 1.3 1.7 -1.3
Arm predicted mass (left) 0.3 1.5 2.0 1.2 1.4 -1.1