Best TWAS P=8.19e-19 · Best GWAS P=4.68e-19 conditioned to 0.000219
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Nerve Tibial | FBXO18 | 0.10 | 0.00 | lasso | 5 | 0.00 | 0.5450 | -7.5 | -6.3 | 3.1e-10 | 0.46 | 0.07 | 0.62 | FALSE |
| 2 | GTEx | Skin Sun Exposed Lower leg | FAM208B | 0.10 | 0.03 | lasso | 4 | 0.03 | 0.0014 | -7.7 | -8.9 | 8.2e-19 | 0.72 | 0.07 | 0.65 | TRUE |
| 3 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | IL2RA | 0.14 | -0.01 | blup | 106 | 0.05 | 0.0019 | 1.2 | -5.5 | 4.0e-08 | 0.66 | 0.01 | 0.73 | TRUE |
| 4 | The Cancer Genome Atlas | Prostate Adenocarcinoma | IL2RA | 0.06 | 0.01 | blup | 107 | 0.02 | 0.0068 | 4.5 | -5.3 | 1.4e-07 | 0.55 | 0.06 | 0.29 | TRUE |