TWAS
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About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Hypothyroidism (self reported)
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chr10:63,253,359-64,724,096
Best TWAS P=1.49e-17 · Best GWAS P=2.08e-30 conditioned to 2.14e-19
63.2M
63.4M
63.6M
63.8M
64M
64.2M
64.4M
64.6M
64.8M
0
5
10
15
20
25
30
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
NTR
Blood
RTKN2
0.02
0.00
bslmm
484
0.00
3.9e-02
7.67
8.5
1.5e-17
0.05
0.25
0.01
TRUE
2
The Cancer Genome Atlas
Brain Lower Grade Glioma
ARID5B
0.05
0.05
lasso
2
0.04
3.7e-05
6.74
-6.5
1.1e-10
-0.54
0.71
0.11
TRUE
3
The Cancer Genome Atlas
Prostate Adenocarcinoma
ARID5B
0.05
0.00
blup
112
0.02
2.7e-03
-0.63
5.4
7.8e-08
0.40
0.03
0.10
FALSE