Best TWAS P=3.85e-09 · Best GWAS P=9.11e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | HRAS | 0.13 | 0.01 | lasso | 8 | 0.00 | 4.3e-01 | -5.7 | 5.4 | 5.9e-08 | -0.84 | 0.02 | 0.75 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | TMEM80 | 0.23 | 0.00 | enet | 11 | 0.03 | 2.8e-02 | -3.5 | -5.6 | 2.8e-08 | 0.60 | 0.08 | 0.46 | FALSE |
| 3 | GTEx | Esophagus Mucosa | DRD4 | 0.09 | 0.02 | lasso | 5 | 0.05 | 1.7e-04 | -5.9 | 5.7 | 9.8e-09 | -0.80 | 0.02 | 0.96 | FALSE |
| 4 | GTEx | Esophagus Mucosa | HRAS | 0.13 | 0.10 | enet | 6 | 0.07 | 1.8e-05 | -5.4 | 5.2 | 1.5e-07 | -0.80 | 0.03 | 0.96 | FALSE |
| 5 | GTEx | Pituitary | HRAS | 0.18 | 0.05 | lasso | 3 | 0.01 | 1.9e-01 | -5.7 | 5.4 | 6.0e-08 | -0.83 | 0.03 | 0.71 | FALSE |
| 6 | GTEx | Whole Blood | RP11-326C3.11 | 0.21 | 0.12 | lasso | 3 | 0.11 | 5.2e-10 | -5.1 | -5.2 | 2.4e-07 | 0.00 | 0.46 | 0.54 | TRUE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IRF7 | 0.03 | 0.03 | blup | 46 | 0.03 | 9.9e-07 | -5.9 | -5.3 | 1.4e-07 | 0.89 | 0.01 | 0.99 | FALSE |
| 8 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | HRAS | 0.07 | 0.01 | blup | 41 | 0.04 | 4.2e-03 | -3.0 | 5.5 | 3.5e-08 | -0.66 | 0.02 | 0.75 | FALSE |
| 9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PHRF1 | 0.04 | 0.05 | blup | 61 | 0.04 | 4.0e-05 | -5.8 | 5.4 | 7.5e-08 | -0.82 | 0.02 | 0.98 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IRF7 | 0.05 | 0.05 | blup | 46 | 0.04 | 1.9e-05 | -5.9 | -5.5 | 4.2e-08 | 0.92 | 0.01 | 0.99 | FALSE |
| 11 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IRF7 | 0.05 | 0.03 | blup | 46 | 0.04 | 2.5e-05 | -5.9 | -5.4 | 7.9e-08 | 0.87 | 0.01 | 0.97 | FALSE |
| 12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | IRF7 | 0.06 | 0.04 | enet | 11 | 0.06 | 8.8e-07 | -3.9 | -5.1 | 3.1e-07 | 0.80 | 0.02 | 0.98 | FALSE |
| 13 | The Cancer Genome Atlas | Soft Tissue Sarcoma | C11orf35 | 0.04 | 0.02 | blup | 41 | 0.03 | 7.6e-03 | -3.6 | -5.4 | 6.9e-08 | 0.76 | 0.02 | 0.31 | FALSE |
| 14 | The Cancer Genome Atlas | Thyroid Carcinoma | CDHR5 | 0.03 | 0.02 | lasso | 2 | 0.01 | 4.1e-02 | -5.4 | 5.6 | 2.1e-08 | -0.84 | 0.02 | 0.87 | FALSE |
| 15 | The Cancer Genome Atlas | Thyroid Carcinoma | IRF7 | 0.07 | 0.10 | lasso | 5 | 0.09 | 3.5e-09 | -5.9 | -5.9 | 3.8e-09 | 0.97 | 0.01 | 0.99 | TRUE |