Hub : Genes

ARID5B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 YFS Blood 0.1082 0.0232 2.6e-15 0.066 0.053 0.071 0.07 0.077 1.1e-20 9.5e-17 2.6e-22 5.2e-22 7.7e-24
2 TCGA Brain Lower Grade Glioma 0.0509 0.0231 6.8e-03 0.050 0.010 0.028 NA 0.038 2.0e-06 2.1e-02 3.1e-04 NA 3.7e-05
3 TCGA Prostate Adenocarcinoma 0.0523 0.0247 3.8e-03 -0.002 0.021 0.001 NA 0.000 6.1e-01 2.7e-03 2.3e-01 NA 3.5e-01
4 TCGA Skin Cutaneous Melanoma 0.3370 0.1320 8.4e-03 0.027 -0.011 -0.001 NA -0.006 6.3e-02 8.2e-01 3.4e-01 NA 5.1e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.2 1.9 2.8 0.3 -1.6 1.5 -1.7
Bipolar Disorder or Schizophrenia 2.6 6.2 7.4 -2.7 -2.7 2.0 -2.5
Depressed Affect (Nagel 2018) 0.4 0.9 2.0 0.3 1.0 -1.4 0.7
Depression (Nagel 2018) 0.8 1.2 3.8 0.3 0.2 -0.9 1.9
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.0 1.0 -0.1 0.1 0.9
Neuroticism (Nagel 2018) 0.2 0.5 1.8 -0.2 -1.4 0.2 0.3
Schizophrenia (2018) 2.5 5.2 14.1 -3.8 -2.3 1.3 0.0
Schizophrenia vs Biploar Disorder 0.0 0.1 0.2 -0.4 0.0 -0.2 0.0
Worry (Nagel 2018) 1.5 3.1 12.2 -0.3 -3.5 0.1 0.1
Alzheimer’s Disease (in mother) 0.8 0.9 3.0 1.7 -0.3 -0.8 -0.2
Alzheimer’s Disease (in father) 0.3 0.4 1.2 -0.5 -0.1 -1.1 -0.1
Alzheimer’s Disease (including proxy) 0.4 0.6 1.1 1.0 -0.9 -0.7 -0.2
Crohns Disease (2017) 0.1 0.3 0.4 0.6 0.3 0.5 -0.6
Irritable Bowel Disease (IBD) 0.5 1.1 2.0 -1.0 -0.8 1.4 -1.0
Ulcerative Colitis (UC) 1.1 2.1 3.0 -1.6 -1.3 1.7 -1.0
Major Depression (MDD) 1.6 2.0 4.0 -1.7 0.0 1.0 -2.0
Reaction Time 1.4 2.6 10.2 0.3 0.3 -3.2 -0.4
Verbal and Numeric Reasoning (VNR) 0.1 0.3 0.8 0.9 0.0 -0.7 0.3
Breast Cancer 0.4 0.9 1.6 1.1 0.4 -1.3 0.8
Ovarian Cancer 0.2 0.3 0.6 -0.8 0.4 0.1 0.7
Prostate Cancer 0.2 0.3 0.5 -0.1 -0.7 0.7 -0.5
Age at First Birth 0.6 0.8 1.3 0.5 1.0 -0.8 1.1
Bipolar Disorder (2011) 0.4 0.3 1.3 -1.2 0.0 0.2 0.0
Body Mass Index (BMI) (2010) 1.3 1.8 2.8 -0.6 -1.7 1.5 -1.3
Coronary Artery Disease (CAD) 1.0 1.1 2.5 1.3 1.6 0.6 0.0
Crohns Disease (2012) 0.4 0.6 1.6 1.3 0.8 -0.5 0.0
Mean Putamen Volume 0.0 0.0 0.1 0.3 0.3 -0.1 0.0
Fasting Glucose 0.3 0.4 1.0 -1.0 0.3 -0.6 -0.0
HbA1C 0.5 0.5 1.6 -0.4 -0.2 1.3 -0.5
HDL Cholesterol 1.1 1.9 3.0 1.2 1.7 -1.7 0.0
LDL Cholesterol 2.4 3.8 5.3 -2.3 -2.2 2.2 0.0
Lupus 5.8 8.8 22.8 2.3 -4.8 2.4 -1.1
Neuroticism (2016) 0.5 0.7 2.0 0.8 -0.2 -1.4 0.0
Primary Biliary Cirrhosis 2.0 2.9 4.3 -1.9 -2.1 1.7 0.9
Rheumatoid Arthritis 8.2 11.4 31.1 1.9 -5.6 3.3 -0.2
Schizophrenia (2014) 1.9 4.2 6.3 -2.0 -2.1 1.4 -2.5
Triglycerides 2.3 3.8 6.0 -1.9 -2.4 2.3 0.0
Type 2 Diabetes (T2D) (2012) 1.9 2.2 4.2 -1.6 -1.4 2.0 0.0
Ulcerative Colitis 1.8 2.6 5.1 -1.3 -1.1 1.6 -2.3
Blood Eosinophil Count 0.1 0.8 2.2 -1.5 0.2 0.9 0.3
Blood Platelet Count 1.6 18.0 46.4 -3.5 -6.8 2.9 -2.2
Blood Red Count 0.2 2.2 8.0 0.6 2.8 0.3 0.5
Blood White Count 0.4 2.7 4.9 -0.3 -2.1 1.1 -2.2
Heel T-Score 2.2 17.4 49.6 -2.5 -7.0 3.0 2.1
BMI 0.5 3.0 6.7 1.1 1.9 -2.6 -0.7
Height 0.7 13.7 34.8 4.2 5.9 -1.4 0.8
Waist Hip Ratio (WHR) 2.7 12.0 19.8 -4.4 -2.6 4.5 -1.5
Systolic Blood Pressure 2.5 12.6 31.1 1.5 5.6 -4.1 -0.4
Smoking Status 0.6 1.4 3.0 -0.9 0.4 1.3 -1.7
Allergy or Eczema 1.7 4.6 8.9 -2.6 1.1 -3.0 -1.1
Cardiovascular Disease 1.0 3.3 10.6 -3.3 1.5 -0.1 -0.7
Hypothyroidism (self reported) 9.0 20.6 41.6 3.4 -6.5 5.4 0.5
Respiratory disease 0.9 2.0 3.9 -1.9 -2.0 0.5 0.2
Type 2 Diabetes (T2D) (2018) 0.4 0.8 2.0 0.0 0.2 -1.2 -1.4
Lung FEV1/FVC ratio 1.9 9.6 24.3 1.4 3.5 -4.9 -0.4
Lung FVC 3.0 15.4 38.1 0.4 -4.7 6.2 -1.0
Neuroticism 0.7 1.6 4.1 -1.0 -2.0 0.1 1.2
Chronotype (morning person) 1.4 3.2 5.4 2.3 -1.1 -1.0 2.3
Hair Pigment 0.1 2.1 3.8 0.8 1.4 -1.4 1.9
Tanning 0.2 1.9 4.3 0.7 2.1 0.0 1.6
Hand grip strength (left) 0.9 2.4 4.5 0.3 2.1 -0.8 -2.1
Number of treatments/medications taken 0.7 1.3 4.3 -2.1 -0.3 -0.4 -0.9
Average weekly spirits intake 0.4 0.5 1.5 -0.0 -0.4 1.2 -0.4
Sensitivity / hurt feelings 0.9 1.5 2.5 -0.6 -1.1 1.6 1.4
Frequency of depressed mood in last 2 weeks 0.4 0.5 1.6 -0.5 -0.5 0.1 1.3
Hearing difficulty/problems: Yes 0.4 0.5 1.8 -0.5 0.3 1.3 0.0
Relative age of first facial hair 0.8 1.7 6.8 0.0 -0.2 -0.4 2.6
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 2.1 -1.4 -0.3 -0.3 -1.5
Ever used hormone-replacement therapy (HRT) 1.0 1.3 2.4 -1.1 1.1 -0.7 -1.6
Ever had hysterectomy (womb removed) 1.2 1.3 1.9 -1.2 1.4 -0.6 -1.3
Systolic blood pressure, automated reading 3.7 10.8 22.9 1.8 4.8 -3.9 1.5
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 1.9 0.4 1.0 -1.4 1.1
Angina 3.9 5.2 9.7 1.3 3.1 -3.0 -0.7
Medication for hormone replacement therapy 0.3 0.3 0.5 -0.5 -0.7 0.5 0.4
Vitamin and mineral supplements 0.1 0.2 0.5 -0.0 0.3 0.7 -0.3
Supplements: Zinc 0.6 0.6 2.2 -0.2 0.1 -1.5 0.5
Medication: Co-codamol 0.5 0.6 1.0 -0.8 -0.2 1.0 -0.8
Medication: Metformin 0.6 0.9 1.7 0.4 0.4 -1.3 -1.2
Diabetes (father) 0.7 0.9 1.3 1.0 -1.1 1.2 -0.1
Diabetes (mother) 0.2 0.3 0.4 -0.6 -0.1 0.6 -0.6
Severe depression (siblings) 2.7 3.0 7.1 -2.7 -1.2 1.6 1.0
Pack years adult smoking proportion 0.7 1.0 2.9 -0.6 1.7 -0.9 -0.3
Impedance of leg (right) 1.3 6.5 12.0 -0.3 -2.8 3.5 2.5
Leg fat-free mass (left) 1.5 7.9 16.9 2.0 4.1 -2.9 -1.4
Trunk fat percentage 0.1 0.2 0.5 0.5 0.3 -0.4 0.7
Hand grip strength (right) 0.7 2.0 4.1 0.9 2.0 -0.7 -1.6
Townsend deprivation index at recruitment 0.4 0.5 1.8 -0.1 1.3 -0.6 0.2
Current tobacco smoking 0.5 0.8 1.7 1.1 -0.2 -1.3 -0.4
Average weekly fortified wine intake 1.0 1.1 2.4 1.5 0.6 -0.5 -1.3
Maternal smoking around birth 0.5 0.7 1.2 1.0 0.1 -0.9 -1.1
Fed-up feelings 0.3 0.6 1.5 1.0 0.3 -0.1 1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.3 1.7 6.0 -0.2 -0.3 -0.9 2.5
Relative age voice broke 0.0 0.0 0.1 0.2 -0.3 0.1 0.1
Taking other prescription medications 0.7 1.1 1.8 -1.3 -1.2 -1.0 -0.5
Age when periods started (menarche) 0.3 0.8 1.5 -1.2 -0.8 -0.7 0.7
Bilateral oophorectomy (both ovaries removed) 1.1 1.2 3.4 1.9 0.8 0.3 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 1.7 3.9 7.7 -1.4 -2.8 2.4 0.8
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 2.8 -0.6 -1.7 0.3 1.3
Qualifications: CSEs or equivalent 0.3 0.3 1.3 0.3 -0.2 0.0 -1.1
Serious illness, injury or assault to yourself 2.2 2.7 9.8 0.4 3.1 -0.2 -0.8
High blood pressure 1.8 4.9 9.5 -3.1 3.1 -0.7 -0.6
Hayfever, allergic rhinitis or eczema 1.1 2.4 7.3 -2.7 0.1 -1.5 -0.4
Multivitamins +/- minerals 1.1 1.3 2.8 1.7 0.9 -0.7 1.2
Stomach or abdominal pain in last month 0.4 0.6 1.1 -1.1 -0.9 0.4 -0.4
Supplements: Glucosamine 1.1 1.4 4.4 -2.1 0.3 -0.9 0.6
Diverticular disease/diverticulitis (self-reported) 3.3 3.9 9.2 1.2 3.0 -2.0 -0.9
Medication: Atenolol 3.4 4.2 9.4 -3.1 2.5 -1.1 0.0
Medication: Levothyroxine sodium 5.3 9.0 20.8 1.1 -4.6 3.7 0.9
Sitting height 0.4 3.1 7.0 2.0 2.6 -1.1 0.3
Chronic bronchitis/emphysema (father) 1.0 1.1 2.3 0.1 0.8 -1.5 -1.3
High blood pressure (mother) 0.7 1.0 2.1 -0.9 -0.1 -1.5 -1.1
Body mass index (BMI) 0.4 1.7 2.9 0.7 1.7 -1.7 -0.8
Impedance of leg (left) 1.9 9.1 15.5 -0.6 -3.7 3.9 2.7
Leg predicted mass (left) 1.5 7.9 17.0 2.0 4.1 -2.9 -1.4
Trunk fat mass 0.2 0.8 1.7 0.8 1.3 -0.9 0.2
Waist circumference 0.2 0.7 2.6 -0.3 1.6 -0.0 -0.5
Number of incorrect matches in round 0.1 0.2 0.7 -0.3 -0.1 -0.2 -0.8
Past tobacco smoking 1.3 2.4 5.3 0.7 0.5 -1.9 2.3
Alcohol usually taken with meals 0.9 1.4 2.7 0.0 -1.5 0.8 -1.6
Nervous feelings 0.9 1.6 6.2 -0.1 -2.5 -0.4 -0.0
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 1.5 -0.4 -1.1 -1.1 -1.2
Hearing difficulty/problems with background noise 1.2 2.0 5.1 -1.5 0.7 -0.3 2.3
Hair/balding pattern: Pattern 2 0.2 0.3 0.5 0.7 -0.5 0.5 0.5
Had menopause 0.2 0.3 1.0 0.2 1.0 -0.4 0.2
Had other major operations 1.1 1.3 4.6 -0.2 0.7 0.3 -2.1
Forced vital capacity (FVC) 1.8 7.0 22.3 0.8 -2.2 4.7 -0.4
Heel bone mineral density (BMD) T-score, automated (right) 2.2 5.0 12.7 -0.7 -3.6 2.5 0.9
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 2.0 -1.4 -0.0 -0.3 0.6
Qualifications: None of the above 1.2 2.6 5.2 -2.3 1.8 -1.0 0.8
Financial difficulties in last 2 years 2.0 2.7 5.2 0.8 1.7 -1.5 2.3
Mouth/teeth dental problems 0.9 1.4 3.6 1.9 -0.6 1.2 -0.2
Heart attack 1.1 1.4 3.1 0.4 1.5 -1.8 -0.1
Allergy 1.4 3.1 9.1 3.0 0.5 1.8 0.2
Pain all over the body in last month 0.8 0.9 1.6 -0.3 -1.3 -1.2 0.6
Diabetes (self-reported) 0.3 0.5 1.0 0.5 -0.6 -1.0 -0.7
Hayfever/allergic rhinitis (self-reported) 1.2 1.7 3.1 -1.7 0.1 -1.8 0.9
Medication: Ramipril 1.0 1.3 2.7 1.6 0.8 0.2 -1.4
Medication: Simvastatin 1.3 1.9 5.5 -0.5 1.3 -2.3 -0.5
Fluid intelligence score 0.4 0.8 1.3 1.1 -0.7 0.4 1.1
Illnesses of siblings 0.4 0.6 2.1 1.5 -0.2 -0.4 0.4
Neuroticism score 1.1 2.3 6.4 -1.3 -2.5 0.6 0.9
Weight 0.9 4.3 10.8 1.8 3.3 -1.7 -0.5
Impedance of arm (right) 0.6 2.8 7.8 -0.1 -1.3 1.3 2.8
Arm fat percentage (right) 0.2 0.7 1.6 0.2 1.3 -1.1 0.4
Trunk fat-free mass 1.3 7.4 19.0 2.2 4.4 -1.9 -1.5
Hip circumference 1.1 4.9 9.6 2.1 3.1 -2.0 1.2
Time employed in main current job 0.6 0.7 2.2 -0.5 0.0 -1.5 -0.5
Alcohol intake versus 10 years previously 0.4 0.6 2.1 -1.5 -0.1 0.2 0.3
Father’s age at death 1.1 1.5 3.2 -0.7 1.5 -1.8 0.4
Worrier / anxious feelings 1.1 2.1 6.6 -1.2 -2.6 -0.5 -0.3
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 1.5 0.4 0.7 -1.2 -0.5
Falls in the last year 0.4 0.5 1.0 -0.6 -1.0 0.7 -0.4
Hair/balding pattern: Pattern 3 0.5 0.8 1.5 -1.2 -0.1 0.7 -1.1
Number of live births 2.4 3.4 4.5 -1.7 -1.8 1.7 -2.1
Forced expiratory volume in 1-second (FEV1) 1.2 4.0 12.3 1.5 -1.0 3.5 -0.7
Pulse rate 2.0 3.4 5.7 1.2 1.0 -2.4 -2.4
Happiness 0.9 1.1 2.3 1.5 0.5 -1.2 0.6
Noisy workplace 0.7 0.8 1.5 -1.2 1.0 -0.8 0.3
Qualifications: A levels/AS levels or equivalent 1.5 3.3 11.7 -0.5 -3.4 0.8 -0.8
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.9 0.4 0.4 -1.0 1.4
Mouth/teeth dental problems: Dentures 3.4 5.7 15.1 0.5 3.9 -2.7 0.7
Asthma 0.8 1.6 5.0 -1.0 -2.2 0.7 -0.1
Medication: Ibuprofen (e.g. Nurofen) 4.3 5.4 10.2 -2.1 -1.5 3.2 2.2
Medication: Cholesterol lowering 0.7 1.1 2.1 0.6 0.8 -1.5 -1.1
Depression (self-reported) 1.0 1.2 3.8 -0.1 0.7 -2.0 -0.8
Medication: Lansoprazole 0.5 0.6 1.2 -1.1 -0.8 -0.3 -0.5
Prospective memory result 0.3 0.4 1.5 -0.2 0.4 -0.1 1.2
Lung cancer (father) 0.8 1.0 2.3 -0.5 -0.8 -0.9 1.5
Illnesses of mother 0.9 1.1 2.8 0.8 0.4 1.7 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.2 10.6 0.8 -1.1 3.3 -0.4
Pulse wave Arterial Stiffness index 0.7 0.9 1.5 -0.3 -1.2 0.6 -1.2
Impedance of arm (left) 0.7 3.4 7.8 -0.2 -1.8 1.6 2.8
Arm fat mass (right) 0.4 1.6 4.1 0.6 2.0 -1.4 -0.3
Trunk predicted mass 1.3 7.4 18.8 2.1 4.3 -2.0 -1.5
Standing height 0.4 4.4 12.1 2.3 3.5 -0.2 0.5
Length of working week for main job 1.6 1.8 4.1 2.0 0.2 -1.7 -0.3
Exposure to tobacco smoke at home 0.3 0.4 0.9 -1.0 0.5 -0.3 0.5
Breastfed as a baby 1.3 1.7 5.6 1.0 2.4 0.2 -0.3
Tense / ‘highly strung’ 2.5 4.1 10.3 -1.7 -3.2 1.2 1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 1.7 0.9 -1.3 -1.1 0.0
Hair/balding pattern: Pattern 4 0.2 0.4 1.3 0.3 0.5 0.2 -1.1
Birth weight of first child 0.2 0.4 0.9 -0.9 0.4 -0.6 0.2
Peak expiratory flow (PEF) 0.7 1.5 2.7 1.6 -0.6 1.6 -0.8
Pulse wave reflection index 2.3 2.8 5.7 -0.5 -2.2 2.4 0.6
Ever highly irritable/argumentative for 2 days 1.7 2.1 7.0 -0.5 -0.5 0.8 2.6
Loud music exposure frequency 0.4 0.4 1.3 0.0 0.2 -0.6 1.1
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 2.7 0.3 -1.6 1.6 -0.5
Mouth/teeth dental problems: Bleeding gums 3.2 4.1 9.3 -1.5 -3.0 2.0 -1.0
Blood clot in the leg (DVT) 0.2 0.3 0.6 -0.6 -0.1 -0.8 -0.5
Medication: Paracetamol 1.9 3.1 5.1 -2.1 -1.3 2.2 -1.2
Headache pain in last month 0.9 1.5 3.5 -0.8 -1.2 1.9 -0.7
Medication for cholesterol, blood pressure or diabetes 1.2 2.0 3.3 0.8 -1.0 1.8 1.7
Glaucoma (self-reported) 0.6 0.8 1.4 0.6 -0.8 -0.8 -1.2
Gout (self-reported) 2.1 2.9 4.3 0.6 2.1 -1.9 1.9
Hypothyroidism/myxoedema (self-reported) 5.5 10.7 17.9 3.0 -4.2 3.8 1.2
Medication: Amlodipine 1.1 1.5 4.1 0.5 1.1 -2.0 -0.7
Medication: Ventolin 100micrograms inhaler 1.9 2.4 4.0 -2.0 -1.8 1.1 -1.1
Birth weight 0.2 0.5 1.1 0.5 0.8 -0.3 -1.0
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.4 0.6 -0.0 0.6 -0.5
High blood pressure (siblings) 0.6 0.8 2.2 -1.5 0.5 0.9 0.1
Forced vital capacity (FVC), Best measure 1.8 6.6 21.1 0.6 -2.2 4.6 -0.4
Body fat percentage 0.1 0.3 0.4 0.4 0.6 -0.5 0.6
Leg fat percentage (right) 0.1 0.4 0.7 0.4 0.9 -0.2 0.8
Arm fat-free mass (right) 1.1 5.7 12.2 1.8 3.5 -1.9 -1.8
Exposure to tobacco smoke outside home 1.0 1.3 2.6 1.6 1.5 -0.6 -0.0
Comparative body size at age 10 0.8 2.2 3.1 -1.4 -1.5 1.3 -1.8
Number of full brothers 0.5 0.6 1.3 -0.2 1.1 1.0 -0.1
Worry too long after embarrassment 0.5 0.9 2.1 -1.1 -1.4 0.5 0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.2 3.2 -1.8 -1.1 -0.5 0.4
Wheeze or whistling in the chest in last year 0.6 1.1 2.2 -1.3 -0.5 -0.5 -1.5
Number of children fathered 2.2 2.5 4.0 -1.0 -2.0 1.1 -2.0
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.2 0.6 -0.3 0.0 0.0 0.8
Age at first live birth 0.2 0.4 0.8 -0.7 -0.7 -0.9 0.0
Pulse wave peak to peak time 0.7 0.9 1.8 0.4 1.3 -0.5 1.2
Health satisfaction 1.9 2.4 6.9 -2.6 -1.6 -0.2 0.5
Shortness of breath walking on level ground 1.2 1.4 2.5 -1.6 0.3 -1.3 1.1
Qualifications: College or University degree 0.6 2.0 4.3 -1.9 -2.1 -0.5 0.2
Eye problems/disorders: None of the above 0.4 0.5 1.2 1.1 0.7 -0.4 -0.0
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.1 0.3 -0.9 -0.7 -1.0
Emphysema/chronic bronchitis 0.2 0.2 0.5 0.3 -0.5 -0.7 0.1
Medication for pain relief, constipation, heartburn 3.0 5.2 9.4 3.1 1.4 -2.9 1.0
Neck or shoulder pain in last month 1.0 1.4 2.4 0.4 -1.0 1.5 1.5
Medication: Blood pressure 1.9 3.4 6.2 -0.6 1.9 -2.5 -1.8
Angina (self-reported) 3.5 4.5 8.2 1.5 2.9 -2.7 -0.6
Migraine (self-reported) 0.7 0.9 3.2 -1.8 -0.0 -0.5 0.3
Medication: Ibuprofen 3.2 3.9 9.0 -1.4 -1.4 3.0 1.6
Medication: Allopurinol 2.7 3.6 7.0 1.7 1.8 -2.6 1.1
Medication: Omeprazole 1.2 1.5 4.8 -1.0 2.2 -0.2 -0.4
Medication: Seretide 50 evohaler 0.2 0.2 0.4 -0.4 0.2 -0.5 -0.6
Mean time to correctly identify matches 1.4 2.7 9.9 0.1 1.0 -3.1 0.0
Heart disease (mother) 1.3 1.6 3.4 -0.3 1.7 -1.8 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 0.5 -0.1 -0.5 -0.7 0.5
Whole body fat mass 0.2 1.0 2.4 0.8 1.5 -1.0 -0.0
Leg fat mass (right) 0.3 1.3 3.2 0.9 1.8 -1.1 -0.3
Arm predicted mass (right) 0.9 4.8 10.2 1.8 3.2 -1.4 -1.9
Pulse rate, automated reading 0.5 1.6 4.8 0.1 -0.7 -1.1 -2.2
Alcohol intake frequency. 0.7 1.7 5.2 -2.3 -0.8 1.0 0.2
Comparative height size at age 10 0.9 4.7 7.9 2.3 2.8 1.1 2.1
Number of full sisters 1.5 1.9 3.5 0.2 1.9 -1.5 -1.4
Suffer from ‘nerves’ 0.9 1.5 3.1 1.6 -0.1 -1.8 -0.5
Overall health rating 0.7 1.6 3.9 -0.1 0.7 -2.0 -1.4
Chest pain or discomfort 1.2 1.7 4.0 0.0 1.7 -2.0 -0.0
Had major operations 0.6 0.7 1.7 1.3 0.5 -0.4 -0.8
Age at last live birth 0.7 0.9 2.9 -1.7 0.1 -0.8 0.5
Family relationship satisfaction 0.9 1.1 3.7 0.8 -0.0 -0.3 1.9
Leg pain on walking 2.3 2.9 6.8 -0.8 -0.7 -1.9 2.6
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 2.1 0.4 1.5 1.0 0.0
Commuting to job workplace: Car/motor vehicle 0.8 0.9 2.6 -0.5 -0.1 -0.8 -1.6
Illness, injury, bereavement, stress in last 2 years 1.7 2.0 3.1 -1.7 -1.8 0.8 -1.3
Medication: Aspirin 0.5 0.6 1.8 -0.4 0.5 -0.5 -1.4
Supplements: Vitamin C 1.0 1.2 4.1 -0.7 0.1 -2.0 0.3
Knee pain experienced in last month 0.7 1.1 2.7 0.3 1.0 -1.6 -0.8
Hypertension (Self-reported) 1.6 4.4 8.5 -2.9 2.9 -0.9 -0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 3.5 -1.9 -0.3 0.3 -0.3
Illnesses of father: Heart disease 0.6 0.8 2.7 -0.2 1.6 -0.8 0.3
Illnesses of siblings: Diabetes 0.2 0.3 0.9 -0.2 0.3 -0.9 -0.0
Smoking status: Previous 2.3 3.4 7.2 -1.1 0.3 2.3 -2.7
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 2.3 1.3 1.5 -1.0 -0.4
Whole body fat-free mass 1.3 7.6 18.6 2.0 4.3 -2.4 -1.5
Leg fat-free mass (right) 1.3 7.0 14.1 2.0 3.8 -2.8 -1.4
Arm fat percentage (left) 0.1 0.6 1.1 0.1 1.0 -1.0 0.4
Average weekly red wine intake 0.8 1.3 2.0 1.4 0.2 1.2 -1.2
Handedness (chirality/laterality): Left-handed 0.5 0.7 1.7 -1.3 -0.3 0.3 0.9
Mood swings 0.4 0.7 1.3 -1.1 -0.2 -0.8 1.0
Loneliness, isolation 0.9 1.3 2.8 1.3 0.7 -1.7 0.0
Long-standing illness, disability or infirmity 0.4 0.5 1.2 -0.9 -0.2 -1.1 -0.4
Ever had bowel cancer screening 2.2 2.6 8.0 -1.2 -0.7 0.7 -2.8
Diabetes diagnosed by doctor 0.8 1.4 3.5 0.3 -0.1 -1.9 -1.4
Ever had stillbirth, spontaneous miscarriage or termination 2.1 2.2 4.1 2.0 -1.2 0.4 -1.8
Friendships satisfaction 0.4 0.5 1.1 1.0 -0.6 0.8 0.2
Qualifications: nursing, teaching 1.5 2.4 3.4 1.7 -1.8 0.3 -1.7
Commuting to job workplace: Walk 0.2 0.2 0.4 0.7 -0.1 -0.4 0.6
Eye problems/disorders: Cataract 0.6 0.7 2.3 -1.5 0.3 -0.6 0.3
Mouth/teeth dental problems: Mouth ulcers 1.2 2.0 5.7 -2.4 -0.4 -1.5 -0.0
Medication for cholesterol 1.1 1.7 3.2 1.8 -1.5 1.0 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.9 1.4 -1.2 -1.1 0.4 -0.8
Back pain experienced in last month 0.7 1.1 2.0 -1.4 -0.8 0.9 -1.0
Mineral and other dietary supplements 1.1 1.5 4.9 2.2 0.5 0.1 0.9
Breast cancer (self-reported) 0.9 1.1 2.2 0.4 1.5 0.4 -1.4
Asthma (self-reported) 0.9 1.8 6.0 -0.8 -2.4 0.6 -0.0
Osteoporosis (self-reported) 0.3 0.4 1.0 1.0 -0.5 0.5 -0.1
Osteoarthritis (self-reported) 0.8 1.1 2.0 -1.3 -1.4 -0.3 0.7
Medication: Aspirin 0.9 1.2 3.4 0.1 1.0 -0.6 -1.9
Medication: Gliclazide 1.1 1.2 3.4 0.2 0.9 0.7 -1.9
Illnesses of father: None of the above (group 1) 0.2 0.2 0.7 0.2 -0.8 0.1 -0.3
Smoking status: Current 0.5 0.8 1.7 1.2 -0.5 -1.3 -0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.2 2.4 6.4 1.3 -1.3 2.5 -0.1
Whole body water mass 1.3 7.5 17.9 2.1 4.2 -2.4 -1.4
Leg predicted mass (right) 1.4 7.3 15.1 2.1 3.9 -2.9 -1.3
Arm fat mass (left) 0.3 1.4 3.4 0.7 1.9 -1.3 -0.2
Number of self-reported non-cancer illnesses 1.1 2.0 3.0 -1.6 0.8 -1.7 -1.3
Average weekly champagne plus white wine intake 0.7 0.9 1.3 -1.1 -0.0 -1.1 -1.2
Miserableness 0.2 0.4 0.4 -0.5 0.6 0.6 -0.6
Guilty feelings 0.7 1.1 2.5 -0.8 -1.0 1.6 0.6
Wears glasses or contact lenses 0.8 0.9 3.6 -0.1 0.2 0.3 1.9
Ever taken oral contraceptive pill 0.3 0.4 0.8 0.6 0.5 -0.4 -0.9
Hearing aid user 0.5 0.6 1.2 -1.1 -0.4 1.0 0.3
Mother’s age at death 2.0 2.5 3.8 1.9 1.6 -1.9 0.6
Financial situation satisfaction 0.2 0.2 0.6 -0.0 0.8 0.4 -0.2
Tinnitus: Yes, now most or all of the time 1.3 1.5 3.0 1.3 1.0 -0.7 1.7
Commuting to job workplace: Public transport 0.9 1.1 3.7 -0.5 0.2 -0.4 1.9
Eye problems/disorders: Glaucoma 0.6 0.7 1.9 0.9 -1.4 0.1 0.0
Medication: Blood pressure 1.5 2.9 9.4 -3.1 1.4 0.5 0.0
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.4 1.0 0.1 -1.2 0.0
Supplements: Fish oil (including cod liver oil) 0.5 0.6 1.4 -1.2 -0.4 0.5 -0.9
High cholesterol (Self-reported) 0.3 0.5 1.3 -1.1 0.4 -0.4 -0.6
Medication: Bendroflumethiazide 0.7 1.1 1.7 -1.1 1.1 -0.4 -1.3
Medication: Paracetamol 1.3 2.1 2.9 -1.7 -0.6 1.7 -1.5
Medication: Lisinopril 0.7 0.9 1.7 -1.3 0.7 -0.8 -0.8
Medication: Atorvastatin 1.8 2.2 4.2 2.0 1.5 -1.5 0.4
Illnesses of father: High blood pressure 0.3 0.4 1.5 0.4 0.3 0.2 -1.2
Alcohol drinker status: Never 2.2 2.7 4.8 -2.2 -1.4 1.7 1.0
Ever smoked 0.6 1.0 3.6 -0.1 0.0 0.7 -1.9
Basal metabolic rate 1.2 6.7 16.0 2.0 4.0 -2.2 -1.3
Leg fat percentage (left) 0.0 0.2 0.5 0.2 0.3 0.1 0.7
Arm fat-free mass (left) 1.2 6.2 14.3 2.0 3.8 -2.0 -1.6
Number of operations (self-reported) 1.1 1.6 5.2 1.1 -0.4 -0.2 -2.3
Average weekly beer plus cider intake 2.2 3.1 5.8 0.8 1.9 -2.4 1.5
Irritability 1.0 1.7 3.8 -2.0 -1.3 0.9 0.6
Risk taking 1.0 1.4 3.3 0.7 0.8 1.8 -1.1
Ever had prostate specific antigen (PSA) test 0.9 1.0 1.9 -0.0 -1.1 1.0 -1.4
Fractured/broken bones in last 5 years 0.1 0.1 0.3 -0.4 0.4 -0.5 -0.1
Age started oral contraceptive pill 1.5 1.9 3.2 -1.8 1.1 -1.3 1.2
Diastolic blood pressure, automated reading 0.4 1.2 4.5 -0.2 2.1 -0.4 -0.2
Ever depressed for a whole week 0.3 0.3 0.5 -0.4 -0.6 0.7 -0.5
Unable to work because of sickness or disability 1.1 1.4 5.3 -0.5 0.3 -2.3 0.2
Commuting to job workplace: Cycle 1.3 1.5 2.5 -1.6 -1.1 1.4 0.7
Myopia 1.6 2.3 4.8 0.3 2.2 -2.0 -0.6
Vascular/heart problems diagnosed by doctor 2.1 5.6 11.3 2.8 -3.4 1.7 0.7
Cholesterol lowering medication 0.8 1.1 2.1 -0.9 1.5 -1.2 0.1
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 2.9 -1.7 1.3 -0.2 -0.6
Pain experienced in last month 1.2 1.9 4.1 2.0 1.5 -0.4 1.1
Supplements: Calcium 0.3 0.3 0.7 -0.6 0.2 -0.8 -0.4
Basal cell carcinoma (self-reported) 0.9 1.1 2.5 0.9 0.7 -1.6 -0.6
Heart attack/myocardial infarction (self-reported) 0.9 1.2 2.4 0.6 1.3 -1.6 -0.4
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.6 -0.5 0.2 -0.8 -0.1
Heart disease (siblings) 0.6 0.8 2.0 0.8 0.5 -1.4 0.3
Alcohol drinker status: Previous 0.8 0.9 3.1 -0.6 0.5 -0.0 -1.8
Pack years of smoking 0.6 0.9 2.7 -0.6 1.6 -0.7 -0.3
Impedance of whole body 1.4 6.9 10.5 -0.6 -3.2 3.0 2.8
Leg fat mass (left) 0.3 1.0 2.4 0.8 1.5 -1.1 -0.3
Arm predicted mass (left) 1.0 5.1 11.7 2.0 3.4 -1.6 -1.5