Best TWAS P=1.15e-08 · Best GWAS P=3.07e-11 conditioned to 0.00066
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | SIK3 | 0.04 | 0.05 | lasso | 3 | 0.04 | 2.2e-04 | -5.7 | 5.7 | 1.2e-08 | -0.87 | 0.11 | 0.76 | TRUE |
| 6 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SIK3 | 0.04 | 0.04 | enet | 8 | 0.03 | 5.2e-04 | -4.1 | -5.4 | 6.3e-08 | 0.71 | 0.12 | 0.84 | FALSE |
| 3 | GTEx | Heart Left Ventricle | AP006216.12 | 0.30 | 0.14 | lasso | 6 | 0.15 | 2.8e-08 | -3.2 | -5.3 | 1.2e-07 | 0.67 | 0.61 | 0.38 | FALSE |
| 4 | YFS | Blood | SIK3 | 0.03 | 0.01 | enet | 20 | 0.02 | 4.7e-06 | -6.3 | 5.3 | 1.2e-07 | -0.50 | 0.02 | 0.98 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SIDT2 | 0.08 | 0.01 | blup | 46 | 0.05 | 2.4e-06 | 1.1 | -5.1 | 2.9e-07 | 0.51 | 0.02 | 0.89 | FALSE |
| 1 | GTEx | Esophagus Mucosa | PCSK7 | 0.12 | 0.03 | enet | 12 | 0.05 | 4.3e-04 | -4.7 | -5.1 | 3.0e-07 | 0.79 | 0.10 | 0.86 | FALSE |
| 2 | GTEx | Heart Left Ventricle | APOA1 | 0.34 | 0.20 | lasso | 7 | 0.18 | 5.2e-10 | -3.2 | -5.1 | 3.0e-07 | 0.64 | 0.79 | 0.21 | FALSE |