Hub : Genes

PCSK7

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.2980 0.0580 8.1e-11 0.215 NA 0.242 NA 0.249 4.5e-12 NA 1.5e-13 NA 6.0e-14
2 GTEx Artery Coronary 0.2350 0.0910 1.3e-03 0.071 NA 0.038 NA 0.071 2.1e-03 NA 2.0e-02 NA 2.2e-03
3 GTEx Artery Tibial 0.2507 0.0494 1.6e-11 0.150 NA 0.181 NA 0.188 8.5e-12 NA 3.8e-14 NA 1.1e-14
4 GTEx Cells Transformed fibroblasts 0.1370 0.0380 4.6e-07 0.112 NA 0.110 NA 0.114 9.8e-09 NA 1.3e-08 NA 6.7e-09
5 GTEx Colon Sigmoid 0.2760 0.0850 1.7e-05 0.088 NA 0.143 NA 0.148 5.1e-04 NA 9.5e-06 NA 6.5e-06
6 GTEx Esophagus Mucosa 0.1210 0.0440 3.1e-04 0.032 NA 0.047 NA 0.045 3.4e-03 NA 4.3e-04 NA 5.5e-04
7 GTEx Esophagus Muscularis 0.1840 0.0570 6.3e-05 0.092 NA 0.072 NA 0.102 3.3e-06 NA 3.8e-05 NA 9.2e-07
8 GTEx Lung 0.0872 0.0331 3.3e-04 0.009 NA 0.023 NA 0.019 6.8e-02 NA 6.4e-03 NA 1.1e-02
9 GTEx Skin Not Sun Exposed Suprapubic 0.2040 0.0670 1.3e-04 0.050 NA 0.074 NA 0.067 1.0e-03 NA 7.0e-05 NA 1.5e-04
10 GTEx Thyroid 0.1210 0.0390 2.6e-05 0.025 NA 0.058 NA 0.054 4.7e-03 NA 2.9e-05 NA 5.6e-05
11 METSIM Adipose 0.1007 0.0304 3.8e-07 0.021 0.055 0.046 0.056 0.034 3.0e-04 1.3e-08 1.7e-07 7.5e-09 7.4e-06
12 YFS Blood 0.1141 0.0219 0.0e+00 0.133 0.142 0.150 0.148 0.154 2.9e-41 5.7e-44 1.3e-46 6.8e-46 7.6e-48
13 TCGA Bladder Urothelial Carcinoma 0.0420 0.0220 8.1e-04 0.025 0.023 0.012 NA 0.017 3.4e-03 4.4e-03 3.3e-02 NA 1.3e-02
14 TCGA Breast Invasive Carcinoma 0.0296 0.0144 6.5e-06 0.028 0.028 0.026 NA 0.024 1.4e-06 1.9e-06 4.4e-06 NA 8.1e-06
15 TCGA Head and Neck Squamous Cell Carcinoma 0.0393 0.0201 9.3e-05 0.029 0.026 0.025 NA 0.026 2.6e-04 5.9e-04 6.4e-04 NA 5.6e-04
16 TCGA Kidney Renal Clear Cell Carcinoma 0.0773 0.0268 5.1e-10 0.103 0.086 0.090 NA 0.091 1.2e-11 7.0e-10 2.4e-10 NA 1.9e-10
17 TCGA Kidney Renal Papillary Cell Carcinoma 0.0700 0.0320 7.1e-05 0.076 0.077 0.058 NA 0.093 3.8e-05 3.7e-05 3.1e-04 NA 5.5e-06
18 TCGA Pheochromocytoma and Paraganglioma 0.2290 0.1370 6.7e-03 0.011 0.020 0.012 NA 0.009 1.1e-01 5.4e-02 1.1e-01 NA 1.3e-01
19 TCGA Prostate Adenocarcinoma 0.0301 0.0175 2.5e-03 0.010 0.019 0.004 NA 0.005 3.1e-02 3.8e-03 1.0e-01 NA 7.8e-02
20 TCGA Thyroid Carcinoma 0.1230 0.0360 5.6e-17 0.199 0.190 0.190 NA 0.190 4.0e-19 3.3e-18 3.0e-18 NA 3.6e-18

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Bipolar Disorder (2018) 0.7 1.1 3.1 -1.3 -1.0 -1.3 -0.1 -0.6 -0.9 -1.6 0.5 -1.3 -1.0 -1.1 0.3 1.1 0.3 1.8 1.1 1.1 1.1 1.1 0.5
Bipolar Disorder or Schizophrenia 0.4 1.0 4.7 -1.6 -1.3 -1.2 0.5 -0.2 -0.4 -1.1 0.7 -0.5 -0.0 0.7 0.8 0.7 0.6 0.9 1.4 1.2 2.2 0.5 1.0
Depressed Affect (Nagel 2018) 0.4 0.8 3.8 0.6 0.4 0.8 0.3 0.7 2.0 1.0 0.1 1.0 0.4 1.6 -0.1 -1.3 0.3 -1.5 -0.4 -0.5 0.1 -0.7 0.0
Depression (Nagel 2018) 1.1 1.6 4.1 1.3 1.1 1.3 -0.8 1.4 0.1 1.3 -1.2 -1.2 -0.9 -1.0 -1.1 -1.7 -1.3 -1.7 -1.2 -1.3 -0.9 -2.0 -1.5
Intelligence (Savage-Jansen 2018) 0.5 1.5 9.9 0.6 1.0 0.6 -0.7 0.4 0.2 0.4 -0.6 1.2 -1.0 -2.2 -0.6 0.1 -1.5 0.4 -1.3 -1.2 -3.1 -0.8 -1.5
Neuroticism (Nagel 2018) 0.4 0.8 3.8 0.4 0.4 0.7 0.1 1.1 1.3 1.0 0.6 1.2 0.0 2.0 -0.1 -1.6 0.4 -1.5 -0.4 -0.5 0.3 -0.9 -0.1
Schizophrenia (2018) 0.3 0.7 3.6 -1.0 -0.9 -0.5 0.7 0.2 0.4 -0.2 0.4 0.4 0.7 1.9 0.8 0.0 0.5 -0.3 0.9 0.7 1.9 -0.2 0.8
Schizophrenia vs Biploar Disorder 0.6 0.8 3.4 -0.0 -0.4 -0.2 1.3 -0.4 1.4 0.1 0.8 1.9 1.3 1.8 0.8 0.1 1.1 -0.5 0.2 0.3 0.1 0.2 0.9
Worry (Nagel 2018) 0.4 0.8 4.3 0.8 0.7 0.7 -0.4 1.2 0.4 1.0 0.6 0.9 -0.2 2.1 -0.2 -1.6 0.3 -1.5 -0.7 -0.8 -0.1 -0.9 -0.3
Alzheimer’s Disease (in mother) 3.9 4.6 9.1 -2.1 -2.5 -2.8 2.3 -1.7 1.0 -2.6 1.3 0.6 1.4 0.4 2.3 2.8 2.0 2.9 2.3 2.4 1.7 3.0 2.0
Alzheimer’s Disease (in father) 0.4 0.4 1.4 -0.8 -0.5 -0.5 0.3 -0.0 -0.2 -0.5 0.4 -0.4 0.6 0.6 0.7 0.6 1.1 0.5 0.5 0.6 1.2 0.8 0.5
Alzheimer’s Disease (including proxy) 5.5 8.0 14.7 -3.1 -3.3 -3.5 2.8 -2.4 0.9 -3.3 1.8 1.1 1.9 0.9 3.1 3.5 3.1 3.5 3.0 3.2 2.7 3.8 2.9
Crohns Disease (2017) 0.2 0.4 2.4 0.0 0.1 0.5 0.1 -0.0 0.3 0.6 -0.3 0.8 0.5 1.5 -0.0 -0.5 -0.6 -1.0 -0.2 -0.3 -1.3 -0.8 0.0
Irritable Bowel Disease (IBD) 0.3 0.6 2.2 0.1 0.2 0.7 -0.9 0.6 -1.5 0.9 -0.5 -0.3 -0.2 0.8 -1.0 -1.3 -0.8 -1.5 -0.0 -0.5 0.2 -1.3 -0.1
Ulcerative Colitis (UC) 0.5 1.0 5.1 0.1 0.3 0.7 -1.4 0.9 -2.3 0.9 -0.4 -1.2 -0.4 0.1 -1.4 -1.4 -0.8 -1.3 -0.1 -0.5 1.2 -1.1 -0.1
Major Depression (MDD) 2.0 2.4 7.6 -1.3 -1.2 -1.1 1.3 -0.2 2.8 -0.9 2.7 0.1 2.2 2.0 1.2 0.2 1.6 -0.4 1.6 1.4 2.1 -0.3 1.8
Reaction Time 0.2 0.4 1.5 0.8 0.5 0.6 -0.6 1.1 -0.6 0.8 -0.6 -0.4 -0.0 0.5 -0.6 -1.2 -0.1 -1.0 -0.5 -0.7 0.5 -0.4 -0.1
Verbal and Numeric Reasoning (VNR) 0.3 0.7 4.3 -0.5 -0.3 -0.4 0.7 -0.7 1.6 -0.3 1.0 2.1 0.9 -0.6 0.6 0.8 0.3 0.4 0.1 0.2 -1.4 0.2 0.2
Breast Cancer 0.3 0.8 4.5 0.5 0.6 -0.6 -0.4 0.5 0.2 -1.2 -0.4 0.9 -1.2 -1.5 0.2 0.6 -0.3 2.1 -0.5 -0.4 -0.8 1.2 -1.1
Ovarian Cancer 4.2 5.6 13.8 -2.5 -2.4 -2.0 2.4 -1.2 3.7 -1.7 3.5 1.6 2.7 2.6 2.5 1.6 2.9 1.1 2.4 2.1 2.2 1.7 2.7
Prostate Cancer 0.1 0.2 1.1 -0.8 -0.2 -0.1 -0.4 -0.0 -0.1 0.2 0.1 -0.2 -0.0 0.4 -0.3 -0.4 0.1 -0.4 0.3 0.1 1.1 0.1 0.5
Age at First Birth 0.3 0.4 2.1 0.2 -0.0 0.2 -0.5 -0.7 -0.9 -0.0 0.0 -0.8 -1.2 -0.7 -0.4 0.2 -0.8 0.4 -0.7 -0.5 -1.4 -0.0 -1.0
Bipolar Disorder (2011) 1.6 1.6 5.7 -0.5 -1.1 -1.5 -0.7 -0.4 -2.4 -1.8 0.2 -1.6 -1.7 -1.7 -0.1 1.2 -0.1 2.1 0.6 1.0 1.3 0.9 -0.3
Body Mass Index (BMI) (2010) 1.7 2.3 4.2 -1.7 -1.5 -1.2 2.0 -1.5 0.8 -1.2 0.8 2.0 1.8 0.4 1.7 1.7 1.8 1.1 1.7 1.6 1.2 1.8 1.8
Coronary Artery Disease (CAD) 0.6 0.8 4.1 -0.2 0.2 -0.4 0.3 -1.7 -0.8 -0.6 -0.1 0.9 -0.4 -2.0 0.3 1.1 0.0 1.3 -0.7 -0.4 -0.5 1.3 -0.4
Crohns Disease (2012) 0.2 0.3 1.6 -0.1 0.1 0.4 0.6 -0.2 1.1 0.3 -0.4 1.0 0.3 0.3 0.1 -0.0 -0.1 -0.5 -0.1 -0.2 -1.3 -0.1 -0.0
Mean Putamen Volume 0.5 0.6 4.0 -1.2 -0.9 -0.6 0.1 -0.5 -1.0 -0.6 1.0 2.0 0.1 0.0 0.2 0.5 0.5 0.3 0.7 0.8 0.7 0.3 0.6
Fasting Glucose 0.7 0.9 3.0 -0.8 -0.9 -0.8 1.1 -0.5 0.4 -0.7 0.6 0.5 0.9 -0.6 1.1 1.4 1.1 1.0 0.9 1.0 0.5 1.7 0.9
HbA1C 1.1 1.2 2.8 -1.1 -1.2 -1.2 1.2 -0.9 0.1 -1.2 0.8 0.9 1.6 -0.0 1.2 1.7 1.0 1.2 1.4 1.5 -0.0 1.0 1.0
HDL Cholesterol 4.2 7.0 17.2 -2.6 -2.5 -3.7 1.9 1.7 1.1 -3.9 4.1 0.9 -0.0 2.9 2.9 1.5 3.1 3.5 2.4 2.8 3.3 1.9 1.7
LDL Cholesterol 6.0 9.4 33.8 -2.4 -2.5 -2.9 2.7 -5.4 1.1 -3.5 1.6 5.8 0.6 -2.2 2.9 3.9 1.9 4.2 2.2 2.3 0.4 4.1 1.9
Lupus 0.6 0.9 4.4 0.8 1.0 0.5 -0.7 0.9 0.4 0.4 -1.5 0.2 -1.3 0.5 -0.7 -0.3 -0.9 0.0 -1.0 -1.0 -2.1 -0.5 -1.1
Neuroticism (2016) 0.2 0.3 1.3 -0.7 -0.7 -0.4 0.6 -0.2 0.3 -0.3 0.9 -0.4 0.6 0.4 0.6 -0.4 0.8 -0.2 0.5 0.5 1.1 -0.0 0.7
Primary Biliary Cirrhosis 1.5 2.1 5.0 1.4 1.5 1.6 -1.1 1.3 -1.0 1.5 -1.9 1.2 -1.2 -1.2 -1.4 -1.0 -1.7 -1.1 -1.5 -1.4 -2.2 -1.6 -1.5
Rheumatoid Arthritis 4.5 6.2 9.9 2.4 2.7 3.0 -2.7 2.5 -1.2 2.7 -2.1 -2.2 -1.8 -0.9 -2.8 -2.9 -3.1 -2.8 -2.5 -2.6 -1.7 -3.1 -2.6
Schizophrenia (2014) 0.2 0.4 4.1 -0.8 -0.7 -0.5 0.3 -0.4 -0.4 -0.2 0.2 -0.3 -0.3 0.7 0.2 -0.2 0.1 -0.3 0.7 0.5 2.0 0.0 0.6
Triglycerides 36.3 59.5 228.0 -6.1 -7.1 -6.9 7.8 -15.1 4.7 -7.7 5.7 11.4 3.4 -4.6 7.6 10.8 5.5 9.2 6.3 6.1 -0.4 9.5 5.8
Type 2 Diabetes (T2D) (2012) 1.3 1.4 3.1 -1.4 -1.5 -1.6 1.0 -1.1 -0.1 -1.6 0.3 0.1 -0.0 -1.5 1.0 1.4 0.9 1.8 1.3 1.3 1.0 1.6 1.1
Ulcerative Colitis 1.0 1.5 4.5 0.7 1.0 1.2 -1.6 2.1 -0.7 1.4 -0.3 -0.8 -0.7 -0.1 -1.6 -2.1 -1.1 -1.8 -0.7 -1.2 0.1 -1.7 -0.6
Blood Eosinophil Count 1.0 8.0 43.3 -1.9 -2.0 -0.1 2.2 0.8 1.9 1.1 2.5 -0.4 5.5 6.6 1.4 -0.7 2.5 -3.0 2.6 2.2 4.2 -0.4 4.0
Blood Platelet Count 4.8 55.5 87.2 8.9 8.9 9.3 -5.3 9.2 -1.8 9.3 -7.9 -6.2 -2.5 -1.4 -6.5 -8.2 -7.3 -9.3 -8.0 -8.0 -6.3 -9.2 -7.2
Blood Red Count 0.6 5.6 18.8 2.2 2.6 3.0 -0.9 2.3 1.2 2.9 -1.6 -4.3 -0.2 -2.0 -1.9 -2.6 -1.9 -3.2 -2.2 -2.3 -1.6 -3.0 -1.9
Blood White Count 0.4 3.1 13.1 0.2 0.1 1.1 0.6 2.2 3.6 1.6 2.3 -1.1 1.8 3.0 -0.1 -2.1 0.8 -3.0 0.3 -0.1 1.4 -1.9 1.1
Heel T-Score 1.6 12.4 19.8 -4.2 -4.0 -3.9 3.1 -4.0 1.2 -3.6 4.2 -0.0 3.3 0.7 3.4 3.5 4.5 3.1 3.8 4.0 4.1 3.7 4.0
BMI 0.7 3.9 12.5 -2.0 -1.8 -0.6 2.5 -0.5 3.5 -0.1 2.3 -0.7 3.3 2.2 1.5 0.2 2.0 -1.2 2.2 2.0 2.3 0.1 2.9
Height 0.1 2.6 28.9 -0.6 -0.3 -0.4 -1.0 -1.7 -5.4 -0.9 -1.4 -1.4 -1.6 -1.4 -0.5 1.6 -1.1 1.6 0.3 0.5 0.6 1.1 -0.6
Waist Hip Ratio (WHR) 3.0 13.6 20.7 -4.3 -4.2 -4.1 4.3 -2.5 2.9 -3.9 3.8 1.5 3.4 3.3 4.3 3.1 4.5 3.0 4.4 4.1 3.3 3.1 4.2
Systolic Blood Pressure 2.8 14.0 34.8 -3.2 -4.2 -4.9 3.2 -3.8 0.7 -5.1 3.0 4.2 1.2 1.2 4.0 5.0 3.2 5.9 3.5 3.8 2.1 5.0 2.5
Smoking Status 0.7 1.7 13.5 0.3 0.5 1.2 0.5 0.7 1.4 1.6 0.0 0.9 1.5 3.7 -0.0 -1.5 0.4 -2.3 -0.5 -0.7 -0.7 -1.2 0.4
Allergy or Eczema 2.7 7.1 19.7 -2.8 -2.7 -1.9 3.1 -1.8 3.1 -1.4 2.9 0.6 4.4 2.6 3.0 2.2 3.1 0.6 2.9 2.9 2.4 1.8 3.6
Cardiovascular Disease 5.3 17.3 40.1 -4.2 -4.5 -5.0 4.3 -6.2 1.1 -5.8 2.2 4.2 -0.1 -2.2 4.1 5.6 3.1 6.3 4.1 4.3 1.0 4.9 2.7
Hypothyroidism (self reported) 3.6 8.2 26.2 2.2 2.0 1.1 -3.2 1.0 -5.1 0.2 -4.0 -0.7 -4.9 -4.6 -2.7 -0.4 -3.6 1.3 -2.5 -2.2 -2.6 -0.4 -3.8
Respiratory disease 0.2 0.4 1.3 -0.2 0.1 0.2 0.2 0.9 1.0 0.7 0.4 0.4 1.1 0.7 -0.0 -0.7 0.3 -1.1 -0.1 -0.1 0.5 -0.7 0.3
Type 2 Diabetes (T2D) (2018) 3.1 5.8 9.9 -3.1 -3.0 -2.9 2.8 -2.9 1.2 -3.1 2.0 0.7 1.3 0.2 2.5 2.6 2.2 2.8 2.9 2.9 1.4 2.4 2.3
Lung FEV1/FVC ratio 2.2 11.3 28.6 -4.2 -3.8 -3.0 4.2 -3.4 3.5 -3.0 5.3 0.3 3.6 0.1 3.6 3.1 3.5 2.2 3.8 3.7 1.8 2.4 4.0
Lung FVC 3.0 15.1 24.6 4.9 4.8 5.0 -3.7 3.4 -2.7 4.9 -4.9 -0.4 -1.5 0.3 -3.7 -4.0 -3.9 -4.7 -4.5 -4.4 -3.5 -3.8 -4.0
Neuroticism 0.8 1.8 5.4 1.0 0.9 1.1 0.0 2.3 2.2 1.5 0.9 0.4 1.1 1.7 -0.1 -2.1 0.2 -2.2 -0.8 -1.1 -0.1 -2.1 -0.5
Chronotype (morning person) 1.6 3.7 7.6 1.9 2.3 2.1 -2.6 2.2 -0.9 2.1 -2.3 0.2 -2.2 -0.2 -2.8 -2.0 -2.1 -1.8 -2.0 -2.0 -1.5 -1.3 -1.7
Hair Pigment 0.5 13.9 21.3 -4.1 -4.4 -4.6 3.6 -3.9 0.6 -4.6 3.9 1.9 1.9 1.3 3.9 4.4 3.7 4.3 4.4 4.5 2.4 4.2 4.2
Tanning 0.0 0.1 0.9 0.2 -0.3 0.1 -0.3 0.1 -0.7 0.2 -0.7 -0.5 -0.2 0.9 -0.1 0.4 0.1 0.1 -0.1 0.0 -0.2 0.5 0.3
Hand grip strength (left) 0.4 1.0 5.1 1.2 0.9 1.1 -0.1 1.2 0.6 1.2 -0.8 -0.4 0.3 1.2 -0.2 -0.3 -1.0 -1.0 -1.0 -0.8 -2.2 -1.0 -0.6
Number of treatments/medications taken 2.2 4.0 9.9 -2.2 -2.4 -2.3 2.4 -3.2 1.6 -2.2 1.9 0.5 1.2 -0.9 2.1 2.3 2.0 2.0 2.1 2.3 0.9 1.8 1.8
Average weekly spirits intake 0.6 0.8 1.6 -0.9 -1.0 -1.3 0.4 -1.0 -0.0 -1.1 0.6 1.2 -0.3 -1.1 0.6 1.0 0.3 1.2 1.0 1.1 0.6 0.8 0.9
Sensitivity / hurt feelings 0.4 0.7 3.1 -0.9 -0.6 -0.9 0.7 0.0 1.4 -0.6 1.3 1.8 0.6 0.6 0.7 0.0 0.9 0.4 0.7 0.6 0.0 0.4 0.7
Frequency of depressed mood in last 2 weeks 0.7 0.9 3.4 0.6 0.6 0.6 -0.4 1.9 0.6 0.8 -0.6 -1.7 -0.2 -0.0 -0.8 -1.4 -0.8 -1.4 -0.6 -0.7 -0.3 -1.6 -0.6
Hearing difficulty/problems: Yes 0.6 0.9 3.2 0.5 0.8 0.3 -0.9 1.4 0.9 0.3 0.3 1.2 -0.9 -1.2 -0.9 -0.5 -1.0 -0.1 -0.8 -0.9 -1.8 -0.9 -1.0
Relative age of first facial hair 0.8 1.7 6.8 1.5 1.6 1.7 -1.1 1.1 -0.3 1.8 -1.1 0.5 -0.3 0.2 -1.1 -1.0 -1.0 -1.5 -1.4 -1.5 -2.6 -1.4 -1.0
Other serious medical condition/disability diagnosed by doctor 0.9 1.1 5.1 0.2 0.5 -0.1 -0.8 0.7 -1.0 -0.2 -1.9 -1.6 -2.3 -2.0 -1.0 -0.1 -0.8 0.5 -0.5 -0.5 -0.8 -0.1 -1.2
Ever used hormone-replacement therapy (HRT) 0.3 0.3 3.4 0.4 -0.1 0.0 -0.9 -0.1 -1.8 -0.1 0.4 0.4 -0.5 -1.0 -0.4 0.0 -0.1 0.4 -0.1 -0.1 0.4 -0.1 -0.6
Ever had hysterectomy (womb removed) 0.1 0.1 0.5 0.2 -0.2 0.1 -0.0 0.1 -0.4 0.3 0.7 0.4 0.2 -0.5 0.0 -0.2 -0.2 -0.3 -0.1 -0.1 0.5 -0.2 -0.1
Systolic blood pressure, automated reading 0.7 2.1 4.9 -1.1 -1.8 -1.9 1.1 -1.5 -0.3 -1.9 1.1 2.1 0.7 0.2 1.4 1.7 0.9 2.2 1.3 1.4 1.5 2.0 0.8
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 2.6 -0.8 -0.5 -0.6 0.7 0.2 0.4 -0.6 1.6 0.5 1.1 1.4 0.9 0.5 0.7 0.4 0.7 0.6 0.2 0.3 0.8
Angina 0.2 0.3 1.0 1.0 0.7 0.7 0.1 -0.8 0.6 0.5 -0.4 0.6 0.1 0.9 0.2 -0.3 -0.2 -0.3 -0.5 -0.6 -0.3 0.3 -0.4
Medication for hormone replacement therapy 3.1 3.4 8.0 -1.8 -1.8 -1.7 1.9 -1.9 0.9 -1.6 2.8 1.5 2.2 2.2 2.0 1.4 2.2 1.2 2.0 1.9 1.7 1.4 2.1
Vitamin and mineral supplements 0.2 0.3 1.1 0.4 0.6 0.2 -0.5 0.4 -1.0 0.2 -0.7 1.0 -0.4 -0.6 -0.5 -0.3 -0.4 -0.1 -0.4 -0.4 0.1 -0.1 -0.3
Supplements: Zinc 0.8 0.8 6.8 0.3 0.1 -0.1 -0.8 -0.6 -2.6 -0.4 -1.8 -1.5 -1.2 -0.2 -0.6 0.1 -0.5 0.6 -0.1 -0.0 0.3 0.3 -0.5
Medication: Co-codamol 0.8 0.9 3.4 1.2 1.2 1.0 -0.8 0.6 -0.1 0.9 -0.7 -0.6 -0.8 -1.6 -0.7 -0.7 -1.0 -0.6 -1.0 -0.9 -1.8 -0.7 -0.8
Medication: Metformin 4.1 5.8 10.8 -3.1 -2.9 -3.1 2.9 -2.7 1.2 -3.3 2.1 0.4 0.9 -0.2 2.5 2.7 2.0 2.9 3.0 3.0 1.7 2.1 2.2
Diabetes (father) 2.5 3.1 4.7 -1.8 -1.9 -2.0 2.0 -1.6 0.4 -2.0 1.2 1.7 0.8 1.6 1.9 2.2 2.0 2.1 1.9 1.9 1.1 2.1 1.9
Diabetes (mother) 2.3 2.9 6.7 -2.1 -2.0 -1.8 2.6 -1.4 1.3 -1.6 1.4 1.6 1.5 0.4 1.9 1.4 1.8 1.3 1.9 1.9 1.7 1.5 1.9
Severe depression (siblings) 0.4 0.5 3.0 0.0 0.2 0.4 -0.4 0.2 -1.0 0.2 -1.1 -0.1 -1.3 -0.8 -0.4 0.3 -0.7 0.2 -0.4 -0.3 -1.7 0.1 -0.6
Pack years adult smoking proportion 2.2 3.4 9.1 -2.1 -1.9 -1.6 1.8 -1.4 1.5 -1.1 3.0 0.7 2.4 2.4 2.0 1.0 2.3 0.3 2.2 2.0 1.8 0.6 2.4
Impedance of leg (right) 0.1 0.5 2.3 0.5 0.6 0.3 -0.2 1.4 0.0 0.4 -0.3 1.5 -0.1 1.5 -0.1 -0.6 -0.2 -0.2 -0.6 -0.6 -0.9 -0.2 -0.5
Leg fat-free mass (left) 0.1 0.4 2.3 -0.7 -0.7 -0.1 0.5 -0.7 -0.2 -0.1 0.3 -1.5 0.8 -0.1 0.2 0.3 0.1 -0.4 0.8 0.8 1.2 0.1 0.8
Trunk fat percentage 0.4 1.4 6.1 -0.2 -0.2 0.8 0.8 0.5 1.1 1.3 1.0 -0.8 2.5 2.3 0.4 -1.0 0.9 -2.2 0.5 0.3 1.2 -0.4 1.4
Hand grip strength (right) 0.7 1.8 7.8 1.9 1.6 1.6 -0.8 0.9 -0.9 1.5 -1.6 -1.2 -0.6 0.3 -0.8 -0.4 -1.6 -1.1 -1.6 -1.4 -2.8 -0.7 -1.1
Townsend deprivation index at recruitment 0.3 0.4 1.5 0.5 0.2 0.4 0.2 0.3 0.8 0.6 1.0 -0.5 1.2 1.2 0.4 -0.3 0.6 -0.8 -0.1 -0.2 -0.3 -0.3 0.2
Current tobacco smoking 0.8 1.3 7.2 -0.2 -0.5 0.2 1.1 0.2 1.7 0.5 1.2 0.5 1.9 2.7 0.8 -0.5 1.4 -1.2 0.7 0.4 0.6 -0.2 1.6
Average weekly fortified wine intake 1.6 1.9 3.4 -1.6 -1.9 -1.7 1.6 -1.5 1.0 -1.7 1.3 -0.3 0.9 0.2 1.4 1.4 1.3 1.5 1.8 1.8 1.4 0.9 1.4
Maternal smoking around birth 0.8 1.2 3.5 -1.3 -0.9 -0.8 0.9 -0.2 1.9 -0.2 1.7 -0.6 1.2 1.2 0.8 0.2 1.6 -0.2 0.9 0.8 1.5 0.3 1.6
Fed-up feelings 0.4 0.7 3.7 0.9 0.6 0.9 0.4 0.3 1.9 1.1 -0.1 0.4 0.8 1.8 -0.0 -0.7 -0.1 -1.4 -0.5 -0.5 -0.8 -0.4 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.0 5.2 1.5 1.5 1.7 -0.5 1.9 1.3 1.9 -0.5 -0.7 0.3 0.8 -0.8 -1.8 -0.9 -2.3 -1.3 -1.4 -1.8 -2.0 -0.9
Relative age voice broke 0.1 0.1 0.8 0.2 0.2 0.0 0.1 -0.6 -0.1 0.1 -0.2 0.6 0.4 -0.4 -0.0 0.7 0.1 0.1 0.1 0.1 -0.9 0.2 0.1
Taking other prescription medications 0.2 0.3 2.2 0.2 0.5 0.2 0.4 -0.3 0.5 0.2 -0.7 0.4 -0.7 -1.0 -0.3 -0.2 -0.3 -0.4 -0.3 -0.2 -1.5 -0.3 -0.4
Age when periods started (menarche) 1.1 2.5 16.2 1.8 1.8 1.8 -0.9 1.1 0.3 1.6 -1.7 0.4 -0.1 1.6 -1.0 -0.9 -1.5 -1.3 -1.7 -1.6 -4.0 -1.1 -1.4
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 2.2 0.4 0.3 0.8 -0.1 1.3 0.1 1.1 -0.4 -0.3 0.1 0.0 -0.6 -1.0 -0.5 -1.5 -0.4 -0.5 -0.9 -1.4 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 2.2 0.3 -0.2 0.2 -0.3 -1.5 -0.7 0.2 -0.2 -0.7 0.8 0.3 -0.2 0.1 -0.1 -0.1 0.0 0.1 0.1 0.2 0.3
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.9 0.9 0.4 0.5 0.0 -0.2 0.1 0.4 -0.6 -1.1 -0.2 -1.0 -0.3 0.1 -0.8 -0.2 -0.6 -0.5 -1.4 -0.8 -0.7
Qualifications: CSEs or equivalent 1.2 1.6 7.7 -0.8 -1.0 -0.8 1.1 0.3 1.9 -0.4 1.2 -0.5 2.1 1.3 1.0 -0.1 1.6 -0.4 1.3 1.0 2.8 0.2 1.6
Serious illness, injury or assault to yourself 1.7 2.0 9.7 1.5 1.5 1.6 -1.1 1.2 0.3 1.4 -1.0 -1.4 -1.5 0.5 -1.2 -1.1 -1.4 -1.1 -1.4 -1.5 -3.1 -1.3 -1.4
High blood pressure 2.6 7.3 16.7 -3.0 -3.1 -3.6 2.6 -2.9 0.0 -3.9 1.3 2.2 0.1 -0.4 2.7 3.4 2.5 4.1 3.0 3.0 1.8 3.1 2.0
Hayfever, allergic rhinitis or eczema 2.9 6.4 13.8 -2.7 -2.4 -1.9 3.2 -2.4 2.2 -1.6 1.5 1.0 3.7 2.2 3.0 2.6 3.1 1.2 2.8 2.9 2.3 2.5 3.4
Multivitamins +/- minerals 0.2 0.2 2.8 0.3 -0.0 0.2 0.2 0.2 1.7 0.1 0.7 -0.4 0.3 0.6 0.3 -0.1 0.3 -0.1 -0.2 -0.1 -0.2 -0.2 -0.1
Stomach or abdominal pain in last month 1.1 1.4 4.0 0.7 0.7 1.1 -0.9 1.5 0.5 1.4 -0.6 -2.0 -0.5 1.0 -1.2 -1.6 -1.0 -1.9 -0.7 -0.9 -0.8 -1.8 -0.3
Supplements: Glucosamine 0.6 0.8 2.3 -0.7 -0.9 -0.1 0.7 -1.4 1.4 0.1 1.5 -0.1 1.5 1.3 0.8 0.6 0.8 -0.2 0.6 0.8 0.2 0.4 1.0
Diverticular disease/diverticulitis (self-reported) 0.9 1.1 6.7 0.7 1.0 -0.0 -1.1 1.6 -0.9 -0.3 -0.3 0.3 -2.6 -1.6 -1.0 -0.6 -0.8 1.0 -1.0 -0.8 -0.3 0.6 -1.2
Medication: Atenolol 0.4 0.5 1.8 -0.0 -0.2 -0.4 0.5 -0.9 1.0 -0.7 -0.2 1.3 -0.6 -0.6 0.3 0.7 0.3 1.0 -0.0 0.0 -0.7 1.3 -0.0
Medication: Levothyroxine sodium 1.3 2.2 5.4 1.1 1.1 0.8 -1.4 0.6 -2.3 0.3 -2.1 0.4 -2.3 -2.1 -1.4 -0.2 -1.9 0.4 -1.4 -1.3 -2.3 -0.4 -2.1
Sitting height 0.2 1.6 9.0 -0.4 -0.3 -0.6 -0.6 -1.3 -3.0 -1.2 -1.1 -0.5 -1.7 -2.6 -0.3 1.3 -0.9 1.8 0.2 0.4 0.4 1.0 -0.5
Chronic bronchitis/emphysema (father) 1.0 1.2 3.2 1.1 1.0 1.1 -0.9 1.2 -0.9 1.1 -1.8 -0.6 -1.0 -0.2 -1.2 -1.3 -1.3 -1.1 -1.0 -1.0 -0.9 -1.2 -1.1
High blood pressure (mother) 4.2 5.9 10.5 -2.3 -2.7 -3.0 2.6 -2.9 0.0 -3.2 1.2 1.6 0.9 0.6 2.7 3.1 2.5 3.2 2.7 2.8 2.1 2.9 2.2
Body mass index (BMI) 0.6 2.7 11.4 -0.9 -1.0 -0.0 1.9 -0.3 3.4 0.5 2.3 -0.2 3.2 2.1 1.2 -0.2 1.6 -1.7 1.4 1.2 1.5 -0.3 2.2
Impedance of leg (left) 0.1 0.4 2.4 0.3 0.3 0.1 -0.0 0.9 0.1 0.1 -0.1 1.6 0.2 1.5 0.1 -0.2 0.0 0.2 -0.4 -0.4 -0.9 0.1 -0.3
Leg predicted mass (left) 0.1 0.4 2.2 -0.7 -0.8 -0.2 0.5 -0.7 -0.3 -0.1 0.4 -1.5 0.8 -0.1 0.2 0.4 0.2 -0.3 0.8 0.8 1.3 0.1 0.9
Trunk fat mass 0.3 1.3 5.9 -0.4 -0.5 0.5 0.9 -0.1 1.1 1.0 1.1 -0.7 2.4 2.0 0.4 -0.7 0.9 -1.9 0.7 0.5 1.4 -0.2 1.5
Waist circumference 2.0 7.4 15.7 -2.8 -2.8 -1.8 3.6 -1.8 3.5 -1.3 3.5 0.5 4.0 2.9 2.8 1.3 3.3 -0.0 3.1 2.9 2.7 1.4 3.7
Number of incorrect matches in round 0.2 0.4 1.8 -0.4 -0.5 -0.5 0.4 -0.6 -1.3 -0.4 0.5 -1.1 -0.2 -0.3 0.3 0.5 0.9 0.4 0.7 0.7 0.9 0.5 0.6
Past tobacco smoking 1.8 3.3 9.2 -1.5 -1.9 -1.9 1.4 -3.0 -0.3 -2.2 1.4 -0.1 0.8 -1.7 1.5 2.1 1.4 2.3 2.0 2.1 2.0 2.2 1.7
Alcohol usually taken with meals 0.3 0.5 2.3 -0.4 -0.1 -0.9 -0.7 0.1 -1.1 -1.0 0.8 0.7 -1.2 -0.4 0.1 0.9 -0.3 1.5 -0.1 -0.0 0.1 0.9 -0.5
Nervous feelings 0.1 0.2 1.4 0.3 0.2 -0.1 0.2 0.8 0.5 -0.0 0.6 0.4 -0.3 1.2 0.2 -0.8 0.1 -0.1 -0.3 -0.3 0.2 -0.3 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 3.9 1.0 0.7 0.8 0.2 1.2 1.4 0.9 -0.1 -0.5 0.2 0.5 -0.3 -0.6 -0.2 -1.0 -0.5 -0.6 -2.0 -0.8 -0.2
Hearing difficulty/problems with background noise 0.3 0.5 4.5 -0.0 0.0 -0.3 0.2 0.5 0.9 -0.2 0.7 2.1 -0.1 0.2 0.0 -0.0 -0.3 0.2 -0.0 -0.1 -1.7 -0.2 -0.0
Hair/balding pattern: Pattern 2 1.0 1.3 2.5 -1.3 -1.2 -1.2 1.0 -1.5 0.3 -1.1 0.7 1.1 1.6 -0.0 0.9 1.2 1.0 1.1 1.4 1.5 0.4 1.1 1.4
Had menopause 1.2 1.5 6.1 1.1 0.8 1.0 -1.4 0.1 -1.5 0.9 -1.2 -0.6 -0.8 -2.5 -1.1 -0.5 -1.5 -0.4 -1.2 -1.2 -1.6 -1.4 -1.7
Had other major operations 0.1 0.1 0.4 -0.3 -0.1 0.1 0.1 0.6 -0.4 0.2 -0.1 -0.2 -0.0 0.1 0.1 -0.3 0.3 -0.3 0.2 0.1 0.5 0.1 0.3
Forced vital capacity (FVC) 2.3 8.9 20.2 3.4 3.6 3.3 -3.3 2.2 -3.4 2.8 -4.5 -1.3 -2.4 -1.8 -3.2 -2.5 -3.6 -2.4 -3.4 -3.2 -1.8 -2.2 -3.5
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.9 5.0 -0.7 -1.0 -0.6 0.8 -2.2 0.5 -0.6 0.9 0.4 1.6 0.5 0.8 1.1 0.6 0.6 0.8 1.0 -0.2 0.8 1.1
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.5 -0.7 -1.2 -1.1 1.0 -1.1 0.7 -0.9 0.7 0.5 -0.0 0.4 0.7 1.2 0.6 0.9 1.0 1.0 -0.1 0.4 1.0
Qualifications: None of the above 1.1 2.3 10.3 0.5 0.9 1.7 -0.3 1.5 1.7 2.3 0.9 -1.0 1.9 1.9 -0.4 -2.7 0.3 -3.2 -0.9 -1.2 0.2 -1.8 0.1
Financial difficulties in last 2 years 0.6 0.8 5.3 0.8 0.7 0.9 0.2 0.7 1.5 1.1 -0.6 -1.2 0.6 1.0 -0.1 -0.4 0.1 -1.0 -0.6 -0.6 -2.3 -0.7 -0.0
Mouth/teeth dental problems 0.1 0.2 0.8 -0.6 0.4 -0.3 -0.3 0.0 -0.0 -0.4 -0.8 -0.1 -0.3 -0.2 -0.2 0.3 -0.1 0.7 0.0 0.0 0.3 0.9 0.1
Heart attack 0.6 0.8 2.3 1.5 1.2 1.1 -0.2 0.1 0.6 1.0 -0.8 1.2 0.0 -0.4 -0.5 -0.8 -0.6 -0.8 -1.1 -1.1 -1.2 -0.6 -1.1
Allergy 1.4 3.1 8.2 1.9 1.8 1.3 -2.2 2.0 -0.8 1.0 -1.0 -0.4 -2.9 -1.5 -2.1 -1.6 -2.2 -0.5 -2.0 -2.0 -1.9 -1.5 -2.4
Pain all over the body in last month 0.4 0.5 1.7 0.5 0.6 0.6 -0.2 0.7 -0.0 0.4 -1.3 -0.8 -0.4 -1.1 -0.3 -0.3 -0.8 -0.2 -0.7 -0.6 -1.1 -0.7 -0.8
Diabetes (self-reported) 2.8 4.3 8.9 -2.5 -2.4 -2.7 2.3 -2.7 0.1 -3.0 1.9 0.7 0.6 -1.1 2.0 2.3 1.6 2.7 2.4 2.4 1.3 2.1 1.7
Hayfever/allergic rhinitis (self-reported) 4.8 6.3 10.7 -3.2 -2.8 -2.3 2.8 -2.1 1.5 -1.9 2.2 2.0 3.3 1.8 2.8 2.3 2.8 1.4 2.8 2.8 3.0 2.4 3.1
Medication: Ramipril 1.2 1.5 4.6 -1.2 -1.3 -1.2 1.2 -2.1 0.0 -1.4 0.7 1.1 0.1 -1.2 1.1 1.9 1.0 1.7 0.9 1.1 -0.4 1.8 0.5
Medication: Simvastatin 3.9 5.7 21.7 -2.3 -2.3 -2.5 2.4 -4.7 0.3 -3.2 0.7 2.1 -0.6 -2.2 2.2 3.3 1.4 3.8 1.9 2.2 -0.2 2.8 1.0
Fluid intelligence score 0.4 0.9 6.1 -0.5 -0.5 -0.5 0.8 -0.9 2.1 -0.4 1.2 2.5 0.6 0.4 0.7 0.8 0.5 0.6 0.2 0.2 -1.1 0.7 0.4
Illnesses of siblings 1.5 2.2 4.4 1.5 1.5 1.5 -1.6 1.6 -2.0 1.5 -2.1 -1.0 -1.2 0.6 -1.5 -1.8 -1.4 -1.7 -1.2 -1.4 -0.3 -1.7 -1.1
Neuroticism score 0.8 1.8 4.4 1.6 1.3 1.4 -0.5 1.9 1.7 1.7 0.2 -0.3 0.3 1.4 -0.6 -2.1 -0.4 -2.1 -1.3 -1.4 -0.6 -1.7 -0.9
Weight 0.3 1.3 5.0 -1.0 -1.0 -0.1 1.3 -0.7 1.2 0.2 1.3 -0.9 2.2 1.3 0.8 0.2 0.9 -1.0 1.2 1.1 1.6 0.1 1.7
Impedance of arm (right) 0.3 1.4 12.3 0.6 0.7 0.6 -1.6 0.8 -3.5 0.4 -1.9 -0.9 -1.4 0.5 -0.9 -0.7 -0.8 -0.0 -0.8 -0.8 0.0 -0.2 -1.1
Arm fat percentage (right) 0.5 2.0 8.3 -0.7 -0.6 0.4 1.2 0.0 1.9 1.0 1.5 -0.4 2.9 2.6 0.8 -0.7 1.4 -2.1 0.9 0.7 1.6 -0.5 1.8
Trunk fat-free mass 0.1 0.5 1.7 -1.0 -0.9 -0.6 0.7 -1.3 -0.0 -0.8 0.3 -0.4 0.1 -0.6 0.3 1.0 -0.0 0.6 0.8 0.9 1.0 0.5 0.4
Hip circumference 0.2 1.0 3.2 -0.7 -0.9 -0.1 1.3 -0.7 1.4 0.1 1.3 -0.6 1.8 0.9 0.7 0.2 0.8 -0.7 1.1 1.0 1.3 0.3 1.5
Time employed in main current job 4.9 5.6 9.9 -2.3 -2.7 -2.4 2.5 -3.1 1.7 -2.2 2.2 0.8 1.8 1.7 2.2 2.1 2.9 1.6 2.8 2.7 2.7 2.4 3.1
Alcohol intake versus 10 years previously 4.1 6.2 11.3 2.6 3.1 3.2 -2.4 2.1 -1.0 3.3 -2.3 -2.0 -1.6 0.3 -2.7 -2.9 -2.4 -3.4 -2.8 -2.8 -2.1 -2.3 -2.3
Father’s age at death 2.1 2.8 5.8 1.5 1.8 1.4 -2.3 1.6 -2.4 1.1 -1.3 -0.1 -2.2 -1.5 -2.0 -1.1 -1.9 -0.8 -1.8 -1.7 -2.0 -1.3 -2.0
Worrier / anxious feelings 0.7 1.3 2.8 1.3 1.4 1.0 -0.8 1.7 0.9 1.0 -0.1 -0.4 -1.5 1.5 -0.8 -1.6 -0.4 -1.1 -1.2 -1.3 -0.9 -0.9 -1.1
Frequency of tiredness / lethargy in last 2 weeks 1.4 2.2 5.5 1.9 1.6 1.8 -1.0 1.5 1.9 2.0 -0.3 0.0 0.2 0.1 -1.2 -1.7 -1.2 -2.1 -1.6 -1.6 -2.3 -1.5 -0.9
Falls in the last year 0.3 0.4 1.3 0.4 0.4 0.7 -0.1 0.3 0.5 0.8 -0.1 -1.0 0.7 -0.5 -0.5 -0.9 -0.3 -1.1 -0.5 -0.5 -1.1 -0.6 -0.2
Hair/balding pattern: Pattern 3 0.2 0.3 1.4 -0.3 -0.4 -0.7 0.3 0.0 -0.4 -0.7 -0.3 1.2 -0.9 -0.2 0.3 0.1 0.5 0.7 0.2 0.2 0.9 0.8 0.0
Number of live births 0.2 0.2 1.9 0.1 0.1 0.3 0.5 0.2 1.4 0.2 0.5 0.5 -0.2 -0.4 0.2 -0.6 -0.1 -0.4 -0.2 -0.3 -0.7 -0.5 -0.3
Forced expiratory volume in 1-second (FEV1) 1.0 3.2 5.5 1.9 2.3 2.1 -2.0 1.2 -2.2 1.9 -2.2 -1.1 -1.0 -1.6 -1.9 -1.4 -2.2 -1.6 -2.0 -1.9 -0.8 -1.3 -2.0
Pulse rate 0.6 1.1 3.4 0.1 0.7 1.1 -0.8 1.3 -0.9 1.0 -1.9 -1.5 -0.9 -1.0 -1.1 -1.4 -0.8 -1.3 -0.8 -0.9 -0.5 -1.0 -0.7
Happiness 1.8 2.2 4.6 1.9 1.9 1.7 -1.1 2.1 1.4 1.7 -0.8 -0.7 -0.1 0.2 -1.2 -1.7 -1.3 -1.7 -1.7 -1.8 -1.7 -1.4 -1.5
Noisy workplace 0.4 0.4 0.8 0.8 0.7 0.6 -0.8 0.5 0.1 0.7 -0.7 -0.7 -0.6 -0.2 -0.7 -0.6 -0.8 -0.6 -0.8 -0.7 -0.3 -0.9 -0.8
Qualifications: A levels/AS levels or equivalent 0.5 1.2 5.7 -0.8 -0.7 -1.4 0.5 -1.0 -0.3 -1.9 -0.2 1.5 -1.1 -0.8 0.7 1.8 -0.2 2.4 0.6 0.8 -0.7 0.8 -0.3
Serious illness, injury or assault of a close relative in last 2 years 7.9 9.1 15.5 -3.2 -3.7 -3.9 2.5 -3.0 0.7 -3.7 2.6 1.5 1.2 1.0 2.7 3.1 3.2 3.4 3.6 3.5 3.9 3.4 3.2
Mouth/teeth dental problems: Dentures 0.3 0.6 1.8 0.2 -0.3 0.4 0.7 0.1 1.3 0.7 1.1 1.1 1.1 0.5 0.4 -0.3 0.4 -1.2 0.0 0.0 -1.1 -0.9 0.5
Asthma 1.1 2.2 5.5 -1.8 -1.7 -1.4 1.8 -0.6 1.2 -0.9 1.5 0.6 2.3 0.9 1.6 0.9 1.9 0.4 1.8 1.7 1.5 0.7 2.0
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.4 0.9 0.6 0.4 -0.8 0.9 -0.1 0.8 0.6 -1.2 0.2 0.2 -0.6 -1.0 -0.5 -1.0 -0.6 -0.6 -0.5 -1.1 -0.1
Medication: Cholesterol lowering 5.5 8.6 31.0 -2.6 -2.7 -3.3 3.0 -5.6 1.2 -3.8 1.8 2.8 -0.7 -2.8 2.6 3.9 1.9 4.2 2.3 2.5 0.0 3.7 1.7
Depression (self-reported) 0.1 0.2 0.7 0.2 -0.2 -0.2 0.1 -0.1 -0.5 -0.2 -0.5 -0.5 -0.8 -0.3 -0.4 -0.6 -0.2 -0.0 -0.2 -0.1 0.6 -0.7 -0.5
Medication: Lansoprazole 2.0 2.3 14.4 -1.2 -0.9 -0.8 1.9 0.3 3.8 -0.5 2.6 1.2 2.3 0.7 1.7 0.4 1.6 -0.2 1.2 1.0 0.0 -0.0 1.3
Prospective memory result 0.4 0.4 3.5 -0.2 -0.2 -0.0 -0.3 -0.7 -1.9 -0.1 -1.1 -0.6 -0.3 -0.9 -0.1 0.0 -0.1 0.3 0.1 0.3 1.4 0.3 -0.1
Lung cancer (father) 0.5 0.6 1.7 -0.8 -0.8 -0.4 0.9 -1.3 0.8 -0.4 0.8 -0.0 1.3 0.5 0.9 0.8 0.9 0.1 0.9 0.9 0.4 0.1 1.1
Illnesses of mother 3.8 4.7 9.7 2.1 2.5 2.9 -2.5 2.4 -0.0 3.0 -0.7 -0.8 -0.7 0.8 -2.3 -2.7 -1.7 -3.1 -2.3 -2.4 -2.3 -2.6 -1.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.9 5.2 1.9 2.3 2.2 -1.8 1.4 -1.8 1.9 -2.3 -1.2 -0.7 -0.6 -1.7 -1.6 -2.0 -1.8 -1.8 -1.8 -0.9 -1.6 -1.7
Pulse wave Arterial Stiffness index 2.3 2.6 4.4 1.4 1.6 1.8 -2.1 1.4 -1.0 1.6 -1.9 -1.5 -1.7 -1.1 -1.9 -1.7 -2.0 -1.5 -1.6 -1.6 -1.3 -1.7 -1.7
Impedance of arm (left) 0.5 2.3 18.0 1.1 1.1 0.9 -1.9 0.7 -4.2 0.8 -2.7 -1.7 -1.5 -0.1 -1.3 -1.0 -1.1 -0.3 -1.2 -1.1 0.0 -0.2 -1.3
Arm fat mass (right) 0.4 1.7 6.7 -0.8 -0.9 0.2 1.4 -0.3 2.0 0.6 1.6 -0.5 2.6 2.0 0.9 -0.3 1.2 -1.6 1.1 0.9 1.7 -0.3 1.7
Trunk predicted mass 0.1 0.5 1.8 -1.0 -0.9 -0.6 0.7 -1.3 -0.1 -0.8 0.3 -0.5 0.1 -0.6 0.3 1.0 -0.0 0.7 0.8 0.9 1.1 0.5 0.4
Standing height 0.2 2.3 20.4 0.1 0.0 -0.0 -1.2 -1.2 -4.5 -0.6 -2.1 -1.6 -2.1 -1.9 -1.0 0.8 -1.7 1.3 -0.4 -0.2 0.1 0.7 -1.2
Length of working week for main job 0.3 0.3 0.9 0.5 0.1 0.2 0.4 0.8 0.9 0.4 0.6 0.6 0.8 0.9 0.3 -0.2 0.3 -0.7 0.3 0.2 -0.1 -0.8 0.6
Exposure to tobacco smoke at home 0.3 0.3 1.2 -0.9 -0.5 -0.6 0.9 0.2 1.1 -0.5 0.9 0.8 0.2 -0.3 0.5 0.4 0.2 0.4 0.5 0.5 -0.6 -0.0 0.2
Breastfed as a baby 1.2 1.5 3.3 1.0 1.1 0.9 -1.6 1.5 -1.8 0.7 -1.3 -0.4 -1.6 -0.9 -1.3 -0.7 -1.6 -0.4 -1.3 -1.2 -0.8 -1.1 -1.8
Tense / ‘highly strung’ 0.4 0.6 5.2 0.6 0.4 0.7 -0.4 0.6 0.1 0.8 0.9 0.1 0.5 2.3 -0.1 -1.1 0.1 -1.2 -0.4 -0.4 -0.1 -0.8 -0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.0 3.1 0.7 0.8 0.7 -1.1 1.0 -0.6 0.9 -0.2 -0.9 -1.2 -0.5 -1.2 -1.8 -0.9 -1.2 -0.9 -1.0 0.3 -1.7 -1.2
Hair/balding pattern: Pattern 4 0.2 0.6 2.9 0.7 0.5 0.5 -0.8 0.4 0.2 0.0 -0.3 -0.2 -1.4 -0.2 -0.6 -0.0 -1.0 0.5 -0.8 -0.8 -1.7 -0.6 -1.4
Birth weight of first child 3.4 6.2 14.0 3.0 2.9 3.4 -2.1 2.6 0.7 3.7 -1.4 -2.0 -0.2 0.1 -2.3 -2.4 -2.1 -3.5 -2.7 -2.8 -2.8 -3.0 -1.9
Peak expiratory flow (PEF) 0.3 0.8 5.6 -0.3 0.2 0.3 0.4 0.1 1.9 0.6 1.6 0.1 2.4 0.8 0.6 0.2 0.6 -0.7 0.1 0.0 0.7 -0.1 0.8
Pulse wave reflection index 0.1 0.2 0.8 -0.1 -0.1 -0.1 -0.0 -0.5 0.7 -0.1 0.6 0.7 0.5 0.9 0.3 0.5 0.3 0.0 0.3 0.3 0.1 0.1 0.4
Ever highly irritable/argumentative for 2 days 0.5 0.6 2.2 -0.3 -0.8 -0.8 0.4 -0.7 1.5 -0.6 1.3 0.4 0.9 -0.8 0.6 1.1 0.3 0.7 0.6 0.6 -0.3 0.4 0.7
Loud music exposure frequency 0.7 0.8 5.3 0.3 0.1 0.5 0.0 0.7 1.4 0.4 -0.5 -1.4 -0.6 -1.1 -0.5 -0.0 -1.0 -0.3 -0.6 -0.6 -2.3 -1.0 -1.0
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 4.3 1.0 0.7 0.2 -1.2 0.4 -0.5 -0.1 -1.5 0.3 -2.1 -1.4 -1.1 -0.0 -1.7 0.5 -0.8 -0.7 -0.7 -0.8 -1.5
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.2 0.6 0.3 0.7 -0.7 -0.3 -1.0 0.8 0.1 -0.5 -0.1 0.4 -0.7 -0.8 -0.4 -1.1 -0.4 -0.5 0.5 -0.9 -0.4
Blood clot in the leg (DVT) 0.7 0.9 2.5 0.5 0.8 0.7 -1.2 0.8 -1.4 0.8 -1.3 0.6 -1.6 0.1 -1.3 -1.1 -1.0 -0.9 -0.8 -0.8 -0.2 -0.5 -0.6
Medication: Paracetamol 0.2 0.3 3.4 0.1 -0.2 -0.2 0.2 -0.1 -0.9 -0.2 -0.1 -1.8 0.2 -0.9 0.2 -0.2 0.1 -0.1 0.2 0.2 1.2 -0.1 0.1
Headache pain in last month 0.1 0.2 0.5 -0.4 -0.4 -0.4 0.6 0.1 -0.2 -0.1 -0.6 -0.4 0.3 -0.5 0.1 0.1 0.1 -0.4 0.4 0.4 0.7 -0.5 0.5
Medication for cholesterol, blood pressure or diabetes 5.2 8.5 20.3 2.8 2.9 3.4 -3.1 4.5 -2.0 3.7 -2.5 -3.1 -0.3 1.4 -2.8 -3.7 -2.5 -3.9 -2.7 -2.8 -0.8 -3.6 -2.3
Glaucoma (self-reported) 0.4 0.4 2.6 -0.1 -0.4 -0.0 1.0 -0.5 1.6 0.0 1.0 0.4 1.4 -0.0 0.7 -0.0 0.3 -0.4 0.2 0.3 -0.2 -0.7 0.3
Gout (self-reported) 0.4 0.5 2.3 -0.1 -0.5 -0.2 0.9 -1.3 1.0 -0.2 0.0 -1.5 0.7 -1.5 0.6 0.2 0.7 0.1 0.3 0.4 0.8 0.2 0.4
Hypothyroidism/myxoedema (self-reported) 2.3 4.4 15.0 1.2 1.5 0.8 -2.1 0.5 -3.8 -0.1 -3.2 0.4 -3.9 -3.3 -1.9 -0.1 -2.6 1.1 -1.8 -1.6 -2.2 -0.0 -2.8
Medication: Amlodipine 1.1 1.6 7.3 -0.8 -1.3 -1.7 0.6 -2.7 -0.5 -1.8 0.4 0.4 -0.4 -1.9 0.4 1.6 0.4 1.8 1.0 1.1 -0.3 1.4 0.6
Medication: Ventolin 100micrograms inhaler 0.2 0.3 1.7 -0.4 -0.5 -0.6 0.7 -1.0 0.1 -0.4 -0.1 1.3 0.3 -0.0 0.7 0.5 0.5 0.3 0.3 0.4 -0.0 0.7 0.4
Birth weight 0.5 1.2 6.7 1.4 1.0 1.1 -0.6 -0.3 -1.1 0.8 -1.0 -0.1 -0.5 -1.2 -0.6 0.2 -1.4 -0.3 -1.3 -1.0 -2.6 -0.7 -1.4
Chronic bronchitis/emphysema (mother) 0.3 0.3 1.7 -0.4 -0.3 -0.1 0.3 0.9 0.5 0.2 0.7 -0.8 1.0 -0.1 0.2 -0.5 0.3 -0.5 0.4 0.2 1.3 -0.3 0.5
High blood pressure (siblings) 2.0 2.9 4.9 -1.8 -2.0 -1.8 1.8 -1.5 1.7 -2.0 1.8 1.1 1.1 -0.3 1.9 2.2 1.8 2.2 1.8 1.9 0.9 2.0 1.5
Forced vital capacity (FVC), Best measure 2.4 8.7 20.8 3.4 3.6 3.3 -3.2 2.3 -3.5 2.9 -4.6 -1.4 -2.2 -0.7 -3.0 -2.8 -3.4 -2.6 -3.3 -3.2 -1.8 -2.4 -3.2
Body fat percentage 0.5 2.0 9.5 -0.4 -0.4 0.7 1.1 0.4 2.0 1.2 1.5 -0.5 3.1 2.6 0.6 -1.1 1.3 -2.4 0.7 0.5 1.3 -0.5 1.7
Leg fat percentage (right) 1.1 4.0 17.5 -0.6 -0.6 0.5 1.9 0.6 4.2 1.2 2.6 1.1 4.1 3.4 1.2 -1.0 1.8 -2.5 1.0 0.7 1.1 -0.6 2.1
Arm fat-free mass (right) 0.1 0.3 1.1 -0.6 -0.6 -0.1 0.7 -0.8 1.1 -0.1 0.7 -0.7 0.7 -0.0 0.2 0.3 0.0 -0.3 0.6 0.6 0.6 -0.0 0.6
Exposure to tobacco smoke outside home 0.5 0.6 1.5 -1.2 -1.0 -0.9 0.9 0.0 0.9 -0.7 0.8 -0.8 0.8 -0.1 0.7 0.5 0.7 0.3 1.1 1.0 -0.3 -0.3 1.1
Comparative body size at age 10 0.1 0.2 0.9 -0.7 -0.1 -0.1 0.9 -0.8 0.3 -0.0 0.5 0.7 0.7 0.2 0.7 0.5 0.3 -0.2 0.3 0.3 -0.5 -0.3 0.4
Number of full brothers 0.4 0.5 4.4 0.1 0.5 -0.0 -0.1 0.5 0.7 -0.0 0.0 -2.1 -0.5 -1.7 -0.4 -0.2 -0.5 0.2 -0.5 -0.4 -0.8 -0.1 -0.6
Worry too long after embarrassment 0.4 0.8 1.6 1.1 0.8 0.7 -1.1 1.2 -0.2 0.6 -0.2 -0.2 -1.3 -0.8 -0.9 -1.2 -0.8 -0.4 -1.1 -1.0 -0.5 -0.7 -1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 3.6 0.6 0.7 0.6 -0.4 1.4 -0.4 0.8 0.6 -1.9 -0.2 -1.2 -0.5 -0.8 -0.2 -0.7 -0.7 -0.7 0.0 -0.9 -0.7
Wheeze or whistling in the chest in last year 0.6 1.1 3.7 -0.1 -0.7 -0.4 1.3 0.7 1.9 0.1 1.2 0.0 1.6 1.9 0.8 -0.3 1.5 -0.7 0.8 0.7 1.4 0.2 1.5
Number of children fathered 0.3 0.3 1.4 0.1 -0.0 0.0 0.5 -0.9 0.3 -0.2 -0.8 0.8 -0.4 0.1 0.2 0.7 -0.1 0.7 -0.4 -0.2 -1.2 1.0 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 1.4 0.2 0.3 0.3 -0.8 0.4 -1.2 0.3 -0.6 0.5 -0.9 -0.0 -0.8 -0.3 -0.7 -0.2 -0.7 -0.6 -0.4 -0.2 -0.9
Age at first live birth 1.5 2.6 5.6 -1.9 -1.8 -1.8 1.8 -2.2 1.0 -1.9 0.4 1.5 0.6 0.5 1.5 2.4 1.4 2.1 1.7 1.8 0.7 2.0 1.6
Pulse wave peak to peak time 2.2 2.6 4.2 -1.3 -1.5 -1.8 2.0 -1.5 0.7 -1.6 1.8 1.6 1.7 1.1 1.8 1.7 1.9 1.6 1.6 1.6 1.3 1.8 1.7
Health satisfaction 0.5 0.6 2.1 -0.5 -0.4 -0.9 0.6 -0.1 -0.1 -1.1 -1.0 -0.9 -0.9 -1.1 0.2 1.2 -0.4 1.5 0.6 0.7 -1.0 0.7 -0.2
Shortness of breath walking on level ground 1.1 1.3 3.6 -1.2 -1.2 -1.0 1.5 -1.0 1.9 -1.1 1.1 1.0 1.1 0.4 1.2 1.0 1.1 0.9 1.3 1.3 0.9 1.1 1.0
Qualifications: College or University degree 0.2 0.6 2.5 0.5 0.3 -0.1 -0.4 -0.2 -0.5 -0.4 -1.2 0.8 -1.6 -0.3 -0.2 0.8 -0.7 1.1 -0.5 -0.3 -1.5 -0.1 -1.0
Eye problems/disorders: None of the above 0.1 0.1 0.6 0.1 0.1 0.1 -0.4 -0.4 0.6 0.2 0.7 0.7 0.3 0.8 -0.0 0.2 0.1 -0.2 -0.1 -0.3 -0.5 -0.3 0.0
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.9 0.7 0.3 0.2 -0.2 0.8 -0.4 0.0 0.1 -1.0 -0.2 -0.1 0.2 -0.2 -0.2 0.1 -0.4 -0.3 -0.4 -0.6 -0.6
Emphysema/chronic bronchitis 0.9 1.0 1.9 1.4 1.3 0.9 -0.6 0.8 0.1 0.9 -1.4 -0.0 -0.8 -0.6 -0.6 -1.2 -1.0 -0.9 -1.1 -1.2 -0.5 -1.4 -1.4
Medication for pain relief, constipation, heartburn 0.6 1.1 2.1 1.0 1.2 1.0 -1.2 0.9 -0.7 0.6 -1.4 0.7 -1.5 -0.4 -1.0 -0.4 -1.3 0.0 -1.3 -1.2 -1.4 -0.3 -1.4
Neck or shoulder pain in last month 0.8 1.2 2.2 -0.9 -1.2 -1.5 0.9 -0.7 -0.2 -1.4 1.3 1.1 0.5 -0.1 1.0 1.0 1.0 1.0 1.5 1.4 1.4 1.1 1.4
Medication: Blood pressure 3.8 6.6 11.1 -2.9 -2.9 -3.3 2.8 -3.2 1.1 -3.3 1.9 1.9 0.7 -0.0 2.6 3.2 2.5 3.3 2.7 2.8 1.3 3.1 2.4
Angina (self-reported) 0.3 0.3 1.1 1.1 0.7 0.8 0.2 -0.9 0.8 0.5 -0.4 0.5 0.2 0.9 0.2 -0.4 -0.1 -0.4 -0.5 -0.6 -0.1 0.4 -0.3
Migraine (self-reported) 2.7 3.4 7.0 1.9 2.0 1.6 -2.6 2.3 -1.4 1.7 -2.1 -0.0 -1.9 -0.9 -2.3 -2.1 -2.0 -1.5 -2.0 -2.1 -0.5 -1.4 -2.0
Medication: Ibuprofen 0.4 0.5 1.4 1.2 0.5 0.3 -0.6 1.1 -0.4 0.7 0.6 -1.0 0.5 -0.1 -0.3 -1.0 -0.2 -0.8 -0.6 -0.6 -0.0 -1.0 -0.2
Medication: Allopurinol 0.9 1.2 5.0 1.2 1.0 1.1 -0.3 0.2 1.3 1.2 -1.0 -2.0 -0.2 -2.2 -0.6 -0.9 -0.6 -1.2 -1.1 -1.0 -0.6 -1.1 -0.7
Medication: Omeprazole 1.7 2.0 7.6 -1.9 -1.7 -1.1 1.7 -0.2 2.8 -0.9 1.9 0.6 2.0 0.7 1.3 0.9 1.1 0.3 1.7 1.5 0.8 0.4 1.7
Medication: Seretide 50 evohaler 0.2 0.2 1.2 -0.4 -0.2 -0.3 0.2 -0.6 -0.3 -0.2 -0.0 0.2 -0.0 -0.1 0.4 0.0 0.7 0.3 0.3 0.2 1.1 0.8 0.3
Mean time to correctly identify matches 0.3 0.6 1.9 0.7 0.5 0.8 -0.8 0.9 -1.0 1.1 -0.5 -0.8 -0.1 0.2 -0.7 -1.4 -0.2 -1.3 -0.7 -0.9 0.1 -0.8 -0.4
Heart disease (mother) 0.5 0.6 2.8 -0.8 -0.7 -0.8 0.9 -1.7 0.6 -0.9 -0.5 0.1 -0.2 -1.0 0.5 1.0 0.1 0.9 0.6 0.7 0.3 0.9 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.6 3.2 1.3 1.6 1.1 -1.1 1.8 -0.1 1.1 -1.3 -1.4 -1.1 -0.1 -1.4 -1.7 -1.0 -1.1 -1.6 -1.7 -0.7 -1.1 -1.3
Whole body fat mass 0.4 1.7 7.4 -0.7 -0.8 0.3 1.3 -0.4 1.7 0.7 1.5 -0.4 2.7 2.1 0.8 -0.5 1.2 -1.7 1.0 0.9 1.7 -0.1 1.8
Leg fat mass (right) 0.7 2.5 10.9 -0.6 -0.6 0.5 1.6 0.2 3.1 1.0 2.0 0.0 3.3 2.6 0.8 -0.8 1.3 -2.3 0.9 0.7 1.2 -0.7 1.8
Arm predicted mass (right) 0.1 0.4 0.9 -0.6 -0.7 -0.2 0.8 -0.9 1.0 -0.2 0.7 -0.6 0.8 -0.1 0.2 0.5 0.1 -0.2 0.7 0.7 0.7 0.1 0.7
Pulse rate, automated reading 0.5 1.7 3.9 -1.4 -1.6 -0.9 2.0 -1.8 0.3 -0.8 0.5 0.4 1.2 1.4 1.5 1.0 1.7 0.3 1.5 1.5 1.3 1.2 1.9
Alcohol intake frequency. 0.6 1.4 4.3 1.4 1.1 1.6 -0.8 0.4 -0.1 1.6 -1.5 -1.8 -0.0 -0.0 -1.2 -1.8 -0.8 -2.1 -0.9 -1.1 0.3 -1.3 -0.7
Comparative height size at age 10 0.6 3.2 11.2 0.9 1.2 1.5 -2.2 0.6 -3.3 1.2 -2.0 -2.5 -1.9 -1.5 -2.1 -1.8 -2.1 -1.3 -1.5 -1.4 1.3 -1.4 -1.7
Number of full sisters 0.8 0.9 4.5 -0.8 -0.9 -0.8 1.3 -2.1 0.8 -0.8 0.9 1.7 0.6 0.2 1.1 0.9 0.6 0.8 0.6 0.7 -0.2 0.9 0.7
Suffer from ‘nerves’ 0.4 0.6 3.2 0.3 -0.1 -0.2 -0.0 0.9 0.6 0.2 0.8 -0.3 0.9 1.6 0.1 -1.0 0.5 -0.8 0.2 0.0 1.8 -0.6 0.5
Overall health rating 0.5 1.1 7.6 -0.4 -0.4 -0.7 1.7 -0.3 2.7 -0.7 1.2 -0.4 1.6 0.3 1.5 0.5 1.2 0.5 0.7 0.7 -0.6 0.7 0.8
Chest pain or discomfort 0.4 0.6 2.1 0.9 0.7 0.8 0.1 1.3 0.5 0.9 -0.2 -0.0 1.0 1.3 -0.1 -1.3 0.0 -1.5 -0.4 -0.6 -0.2 -1.0 -0.2
Had major operations 1.8 2.1 4.4 1.9 1.5 1.6 -1.4 1.3 1.0 1.6 0.4 0.5 -0.2 -1.0 -1.5 -1.6 -1.6 -1.8 -1.6 -1.6 -1.9 -2.1 -1.4
Age at last live birth 1.5 2.2 4.3 -1.7 -1.6 -1.5 1.7 -1.8 1.1 -1.6 0.8 1.3 0.9 0.7 1.6 2.1 1.4 1.7 1.5 1.6 0.8 1.7 1.4
Family relationship satisfaction 1.7 2.1 4.2 1.5 1.6 1.6 -1.0 1.9 0.4 1.5 -1.5 -2.0 -1.0 0.5 -1.2 -1.1 -1.3 -1.4 -1.5 -1.5 -2.1 -1.4 -1.4
Leg pain on walking 0.8 1.0 4.5 1.3 1.0 1.4 -0.3 0.7 0.4 1.3 -0.6 -0.9 0.2 -0.8 -0.5 -0.5 -0.8 -1.0 -1.1 -1.0 -2.1 -1.1 -1.0
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.9 -0.2 -0.1 0.1 0.3 0.2 0.9 0.0 0.1 0.6 0.8 -0.5 0.2 0.0 -0.2 -0.3 0.3 0.3 0.2 -0.3 0.2
Commuting to job workplace: Car/motor vehicle 0.6 0.7 3.7 -0.8 -0.8 -0.6 1.3 0.1 1.9 -0.8 0.8 0.7 0.5 0.8 0.8 0.4 0.6 0.5 0.9 0.9 -0.8 0.4 1.0
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 1.5 0.3 0.7 0.8 -0.0 0.5 -0.0 0.7 0.3 -0.4 0.5 -1.2 -0.2 -0.6 -0.6 -0.9 -0.5 -0.5 -0.2 -0.7 -0.4
Medication: Aspirin 0.2 0.3 1.3 -0.0 -0.1 -0.3 0.7 -1.1 1.1 -0.4 0.5 0.3 -0.4 -0.9 0.5 0.3 0.3 0.2 0.2 0.2 -0.5 0.0 -0.0
Supplements: Vitamin C 0.6 0.7 5.6 -0.5 -0.5 -0.6 0.3 -0.6 -1.4 -0.8 -0.5 -2.4 -1.1 0.9 0.3 0.7 0.1 0.9 0.5 0.5 -0.1 0.8 0.1
Knee pain experienced in last month 0.3 0.5 3.1 -0.7 -0.2 0.3 -0.3 0.8 0.2 0.7 0.6 -1.0 1.0 -0.0 -0.2 -1.1 0.5 -1.3 0.3 0.2 1.8 -0.2 0.5
Hypertension (Self-reported) 2.5 7.1 14.5 -3.0 -3.1 -3.4 2.6 -3.0 0.0 -3.7 1.4 2.0 0.3 -0.1 2.7 3.3 2.5 3.8 3.0 3.1 2.2 3.0 2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.2 2.6 9.3 -2.0 -1.6 -1.1 2.1 -0.7 3.0 -0.7 2.5 2.0 2.2 1.0 1.6 0.0 1.3 -0.2 1.5 1.3 1.5 -0.3 1.7
Illnesses of father: Heart disease 1.6 2.2 14.1 1.3 1.6 1.4 -0.5 -0.0 1.1 1.3 -1.8 0.6 -1.0 -2.0 -0.8 -0.2 -1.2 -0.6 -1.7 -1.6 -3.8 -0.8 -1.7
Illnesses of siblings: Diabetes 0.5 0.7 3.1 -0.6 -0.6 -0.7 0.9 -1.8 1.0 -0.6 1.5 0.7 0.8 0.0 0.6 0.6 0.7 0.5 0.6 0.6 -0.2 0.7 0.7
Smoking status: Previous 1.5 2.2 5.2 1.3 1.6 1.5 -1.4 2.3 -0.2 1.8 -1.4 -0.4 -0.7 1.0 -1.4 -1.6 -1.3 -1.7 -1.7 -1.7 -1.7 -1.8 -1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.5 2.6 -0.5 -0.3 -0.7 0.1 -0.2 -0.8 -0.9 -0.7 -1.6 -0.6 0.1 0.2 1.0 0.2 1.3 0.4 0.5 0.7 1.0 0.2
Whole body fat-free mass 0.1 0.4 1.2 -0.8 -0.8 -0.4 0.6 -1.0 0.0 -0.5 0.4 -0.9 0.4 -0.5 0.2 0.7 -0.0 0.2 0.8 0.8 1.1 0.3 0.6
Leg fat-free mass (right) 0.1 0.5 2.3 -0.8 -0.9 -0.2 0.6 -0.9 -0.3 -0.3 0.4 -1.5 0.8 -0.2 0.3 0.6 0.2 -0.1 0.9 0.9 1.2 0.3 0.9
Arm fat percentage (left) 0.4 1.8 8.0 -0.5 -0.5 0.6 1.0 -0.1 1.4 1.1 1.1 -0.9 2.8 2.4 0.6 -0.9 1.3 -2.2 0.8 0.6 1.7 -0.4 1.7
Average weekly red wine intake 0.4 0.6 4.1 0.4 0.6 0.3 -0.5 0.1 0.9 0.1 0.3 0.2 -0.7 -1.7 -0.4 0.4 -1.2 0.4 -0.7 -0.6 -2.0 -0.0 -0.9
Handedness (chirality/laterality): Left-handed 0.3 0.4 1.4 0.4 0.7 0.5 -0.4 0.5 -0.0 0.4 -1.1 -0.3 -0.9 -0.6 -0.4 -0.3 -0.7 -0.2 -0.8 -0.7 -1.2 -0.3 -1.0
Mood swings 0.4 0.7 6.2 0.1 -0.0 0.3 0.4 0.1 1.8 0.6 0.4 0.6 0.8 2.5 0.3 -0.5 0.9 -1.0 0.1 0.1 0.7 0.1 0.9
Loneliness, isolation 1.2 1.6 4.3 1.1 1.2 1.5 -0.8 2.0 0.9 1.8 -0.1 -1.3 0.5 -0.5 -0.9 -1.9 -0.7 -2.1 -1.1 -1.2 -0.5 -2.0 -0.8
Long-standing illness, disability or infirmity 0.3 0.5 3.1 -0.6 -0.2 -0.5 0.9 -0.3 1.8 -0.6 -0.1 -0.5 -0.7 -1.1 0.4 0.5 0.1 0.6 0.2 0.3 -1.3 -0.1 -0.2
Ever had bowel cancer screening 0.4 0.5 2.6 -0.8 -0.9 -0.6 0.5 0.3 0.3 -0.6 1.2 1.6 0.6 0.4 0.6 0.2 0.5 0.3 0.7 0.5 1.0 -0.1 0.3
Diabetes diagnosed by doctor 2.2 3.6 8.2 -2.3 -2.2 -2.4 2.0 -2.9 -0.0 -2.8 1.8 0.7 0.4 -1.0 1.7 2.2 1.3 2.6 2.1 2.1 0.4 1.8 1.4
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.5 -1.0 -0.5 -0.9 1.0 -0.1 0.8 -0.9 -0.8 -0.8 -0.3 -0.4 0.6 0.7 0.7 1.1 0.7 0.7 0.6 1.2 0.5
Friendships satisfaction 0.5 0.7 3.6 0.8 0.6 0.8 0.2 0.9 1.1 0.8 -0.5 -0.7 0.3 1.3 -0.1 -0.2 -0.6 -0.9 -0.6 -0.6 -1.9 -0.7 -0.5
Qualifications: nursing, teaching 1.7 2.7 6.5 -2.1 -1.7 -2.3 1.6 -1.2 -1.1 -2.4 -0.7 0.7 -1.0 -0.9 1.3 2.3 1.0 2.6 1.9 2.0 1.1 1.7 1.0
Commuting to job workplace: Walk 0.9 1.0 3.8 -0.9 -1.2 -1.0 1.1 -1.9 0.6 -1.1 0.8 0.3 0.2 -0.6 1.0 1.8 0.7 1.2 1.0 1.0 0.2 0.9 0.7
Eye problems/disorders: Cataract 0.4 0.4 1.5 -0.5 -0.2 -0.6 0.7 -0.2 -0.8 -0.6 -1.0 -0.2 -0.1 -1.2 0.5 0.4 0.3 0.9 0.2 0.5 0.4 1.2 0.2
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 2.1 0.9 0.5 0.8 -0.4 1.0 -0.1 0.7 -0.1 -0.2 -0.4 0.3 -0.4 -1.2 -0.6 -0.9 -0.7 -0.8 0.0 -1.4 -1.1
Medication for cholesterol 5.1 7.7 19.5 3.0 3.2 3.0 -2.9 4.4 -1.1 3.4 -2.3 -2.2 -1.1 -0.4 -2.8 -3.4 -2.5 -3.5 -2.9 -3.1 -1.2 -3.2 -2.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 5.5 -1.1 -0.9 -0.6 0.2 -0.1 -0.8 -0.4 0.1 -0.6 0.5 0.6 0.3 0.2 1.2 0.0 1.2 1.1 2.4 0.8 1.5
Back pain experienced in last month 1.7 2.5 5.9 2.2 1.7 1.8 -1.6 1.3 -1.9 1.7 -0.8 -2.4 -1.3 -0.7 -1.5 -1.8 -1.3 -1.7 -1.3 -1.3 -1.0 -1.7 -1.2
Mineral and other dietary supplements 0.1 0.1 1.0 -0.2 0.0 -0.6 0.1 0.6 -0.1 -0.4 -0.0 1.0 -0.3 0.2 -0.1 -0.1 0.1 0.3 0.2 0.0 -0.2 0.5 0.4
Breast cancer (self-reported) 0.9 1.1 3.9 1.1 0.8 0.9 -0.9 0.8 -1.8 0.7 -1.5 -2.0 -1.2 -1.6 -0.7 -0.5 -0.5 -0.4 -1.0 -0.8 -0.2 -0.5 -1.2
Asthma (self-reported) 1.0 2.0 5.5 -1.6 -1.6 -1.4 1.7 -0.6 1.3 -0.9 1.7 1.1 2.3 0.9 1.6 0.9 1.8 0.4 1.7 1.6 1.3 0.8 1.9
Osteoporosis (self-reported) 0.2 0.2 1.5 -0.5 -0.1 -0.1 -0.1 -1.1 -0.5 -0.3 0.2 1.2 -0.3 -0.2 0.0 0.6 -0.1 0.6 0.0 0.1 -0.2 0.7 -0.0
Osteoarthritis (self-reported) 0.8 1.1 3.8 1.1 1.1 1.3 -0.1 0.4 1.4 1.6 -0.2 -0.1 1.3 0.5 -0.5 -1.5 -0.6 -1.9 -0.9 -1.0 -1.1 -1.2 -0.3
Medication: Aspirin 0.2 0.2 1.4 0.3 0.1 -0.1 0.3 -1.2 0.7 -0.2 0.1 -0.2 -0.8 -1.1 0.1 0.1 -0.0 0.1 -0.0 -0.1 -0.6 -0.1 -0.2
Medication: Gliclazide 4.7 5.3 9.4 -2.5 -2.6 -2.9 1.9 -3.0 -0.6 -3.1 1.7 0.4 0.6 -0.4 2.1 2.4 2.1 3.0 2.6 2.5 2.9 3.0 2.1
Illnesses of father: None of the above (group 1) 0.2 0.3 1.6 0.1 -0.0 -0.3 -0.3 0.5 -1.1 -0.4 0.6 -1.0 -0.0 -0.6 -0.0 -0.5 -0.1 0.4 0.1 -0.0 1.3 -0.0 -0.2
Smoking status: Current 0.5 0.8 5.2 0.2 -0.1 0.4 0.8 0.4 1.5 0.6 0.9 0.9 1.3 2.3 0.5 -0.7 0.8 -1.1 0.2 0.0 -0.1 -0.4 0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.0 4.0 1.8 1.8 1.8 -1.4 1.5 -0.2 2.0 -0.1 -0.9 0.4 -0.6 -1.2 -1.5 -1.6 -2.0 -1.7 -1.7 -1.0 -1.5 -1.3
Whole body water mass 0.1 0.4 1.1 -0.9 -0.8 -0.4 0.6 -1.0 0.1 -0.4 0.5 -0.9 0.4 -0.3 0.3 0.7 0.0 0.2 0.8 0.8 1.1 0.3 0.6
Leg predicted mass (right) 0.1 0.5 2.3 -0.8 -0.8 -0.2 0.6 -0.9 -0.3 -0.3 0.4 -1.5 0.8 -0.1 0.3 0.6 0.2 -0.0 0.9 0.9 1.2 0.3 0.9
Arm fat mass (left) 0.4 1.7 6.5 -0.9 -0.9 0.1 1.4 -0.5 1.9 0.5 1.4 -0.6 2.5 2.0 0.9 -0.2 1.3 -1.5 1.2 1.0 1.6 -0.0 1.8
Number of self-reported non-cancer illnesses 1.8 3.1 6.9 -2.2 -1.9 -2.2 2.1 -2.6 0.9 -2.0 0.6 1.7 0.9 -1.1 1.8 1.8 1.9 1.9 1.8 1.9 1.5 1.6 1.6
Average weekly champagne plus white wine intake 0.7 0.9 4.1 -0.2 -0.9 -1.4 0.2 -0.4 -0.7 -1.5 0.4 1.5 -0.3 -0.4 0.6 1.5 0.3 2.0 0.5 0.7 0.9 1.4 -0.1
Miserableness 0.3 0.5 3.5 0.3 0.2 0.6 0.6 0.2 1.5 0.7 0.3 0.9 0.9 1.9 0.4 -0.6 0.3 -1.0 -0.2 -0.3 -0.4 -0.3 0.1
Guilty feelings 2.1 3.1 6.1 1.9 2.1 1.9 -1.8 2.5 1.2 1.9 -0.9 -1.4 -1.2 -0.7 -1.7 -2.2 -1.4 -1.9 -2.0 -2.0 -1.4 -2.2 -1.9
Wears glasses or contact lenses 0.1 0.1 0.9 -0.3 -0.2 -0.1 -0.1 -0.4 0.0 0.1 1.0 -0.4 0.5 0.1 0.3 -0.1 0.4 -0.1 0.1 0.1 0.5 -0.3 0.2
Ever taken oral contraceptive pill 3.0 3.3 7.5 -1.6 -1.8 -2.2 1.8 -1.9 -1.0 -2.4 -0.2 1.1 0.6 0.8 1.7 2.7 1.5 2.7 2.1 2.2 0.9 2.7 1.9
Hearing aid user 0.1 0.1 0.6 0.3 0.3 0.0 0.2 0.4 0.8 0.0 0.2 -0.0 0.3 0.5 0.2 -0.0 0.1 -0.1 0.1 0.0 -0.2 -0.1 0.1
Mother’s age at death 0.7 0.9 4.4 -0.4 -0.6 -1.0 -0.1 0.0 -1.7 -1.4 0.2 0.4 -1.1 -1.3 0.2 1.1 -0.3 2.1 0.4 0.5 1.2 1.0 -0.5
Financial situation satisfaction 0.6 0.7 4.5 0.6 0.7 0.8 0.4 0.9 1.7 0.8 0.0 -1.0 0.0 1.4 0.0 -0.2 -0.1 -0.6 -0.5 -0.5 -2.1 -0.2 -0.2
Tinnitus: Yes, now most or all of the time 0.4 0.4 1.8 0.3 0.6 0.5 -1.1 1.3 -0.3 0.5 -0.5 -0.9 -0.1 0.2 -0.6 -0.3 -0.6 -0.2 -0.7 -0.7 -1.1 -0.1 -0.6
Commuting to job workplace: Public transport 0.1 0.1 0.8 0.1 0.2 0.1 -0.2 -0.5 -0.2 0.3 -0.1 0.2 0.2 0.9 -0.1 -0.2 0.1 -0.3 -0.2 -0.3 0.9 -0.1 -0.0
Eye problems/disorders: Glaucoma 0.2 0.2 1.2 0.3 0.2 0.5 0.3 -0.0 1.1 0.4 0.4 0.0 0.3 -0.1 -0.1 -0.7 -0.3 -0.7 -0.2 -0.2 -0.1 -1.1 -0.4
Medication: Blood pressure 1.7 3.3 7.0 -1.8 -2.0 -2.0 1.6 -2.6 0.8 -2.3 1.4 1.2 0.6 0.2 1.9 2.4 1.9 2.6 1.8 2.0 0.9 2.3 1.3
Pain type(s) experienced in last month: Hip pain 1.4 1.7 6.4 1.2 1.2 1.6 -0.6 0.8 0.8 1.7 -0.6 -2.5 0.0 -0.7 -1.1 -1.9 -0.6 -2.2 -0.9 -1.0 -0.6 -2.1 -0.8
Supplements: Fish oil (including cod liver oil) 0.2 0.2 1.4 -0.4 -0.4 0.0 0.1 -0.7 0.0 -0.0 0.4 -1.2 0.5 -0.3 0.5 0.6 0.7 0.2 0.3 0.4 0.8 0.1 0.1
High cholesterol (Self-reported) 8.0 14.2 51.0 -3.1 -3.3 -3.7 4.1 -7.1 1.9 -4.7 1.3 5.2 -1.0 -4.1 3.4 5.0 1.8 5.6 2.4 2.8 -1.9 4.2 1.4
Medication: Bendroflumethiazide 2.0 3.0 6.3 -2.0 -2.1 -2.3 1.7 -1.9 0.6 -2.4 0.5 1.0 0.6 0.1 1.8 1.9 1.7 2.5 1.7 1.9 1.2 2.5 1.5
Medication: Paracetamol 0.2 0.2 1.4 0.6 0.1 0.2 0.3 0.2 -0.5 0.3 0.3 -1.2 0.8 -0.4 0.2 -0.5 0.2 -0.5 0.0 -0.0 1.0 -0.4 0.2
Medication: Lisinopril 2.1 2.7 5.2 -1.8 -1.9 -1.3 2.3 -1.4 2.0 -1.2 1.3 1.3 1.8 2.2 1.6 1.4 1.7 0.8 1.8 1.8 0.6 1.2 2.1
Medication: Atorvastatin 4.5 5.6 22.5 -1.6 -2.0 -2.2 2.5 -4.7 0.8 -3.0 1.1 3.0 -1.0 -1.6 1.8 3.4 1.0 3.4 1.7 1.9 -2.2 2.7 1.3
Illnesses of father: High blood pressure 3.0 3.8 7.3 -1.9 -2.1 -2.1 1.6 -2.2 1.4 -2.0 2.3 2.7 0.9 1.2 1.8 1.7 1.9 1.7 2.1 2.0 1.8 2.0 2.3
Alcohol drinker status: Never 0.4 0.5 2.0 -0.7 -1.2 -0.6 0.5 -0.7 -1.1 -0.7 -0.0 -1.4 0.3 -0.1 0.4 0.5 0.1 0.3 0.8 0.8 1.3 0.1 0.3
Ever smoked 1.6 2.8 9.4 1.2 1.8 1.8 -1.4 3.1 0.1 2.1 -1.2 0.0 -0.5 2.2 -1.4 -2.1 -1.1 -2.4 -1.6 -1.8 -1.3 -2.1 -1.2
Basal metabolic rate 0.1 0.5 1.5 -0.9 -0.9 -0.3 0.9 -0.9 0.4 -0.3 0.6 -1.0 0.9 0.1 0.4 0.6 0.3 -0.1 1.0 1.0 1.2 0.3 0.9
Leg fat percentage (left) 1.1 4.0 17.1 -0.6 -0.7 0.4 2.0 0.3 4.1 1.0 2.6 1.1 4.1 3.4 1.4 -0.7 1.9 -2.2 1.1 0.8 1.0 -0.4 2.2
Arm fat-free mass (left) 0.1 0.5 1.8 -0.8 -0.8 -0.3 1.0 -0.6 1.4 -0.3 1.2 -0.0 0.9 0.1 0.5 0.6 0.2 -0.1 0.8 0.8 0.7 0.0 0.7
Number of operations (self-reported) 0.3 0.5 1.1 0.7 0.7 0.9 -0.2 1.0 0.7 1.0 -0.1 0.2 -0.1 -0.9 -0.6 -0.8 -0.6 -1.1 -0.6 -0.6 -0.5 -1.0 -0.5
Average weekly beer plus cider intake 0.4 0.5 3.8 -0.0 0.0 0.6 -0.3 0.1 0.2 0.6 0.3 -1.3 0.6 2.0 -0.3 -0.5 0.1 -0.9 -0.1 -0.2 -1.2 -0.6 0.5
Irritability 1.0 1.6 10.4 0.9 1.0 1.3 -0.2 1.7 0.8 1.5 1.1 0.8 0.8 3.2 -0.2 -1.5 -0.3 -1.8 -0.8 -0.9 -0.8 -1.5 -0.6
Risk taking 0.6 0.9 2.9 0.5 0.5 0.5 -1.1 1.7 -0.5 0.4 -1.5 -1.1 -1.5 -1.4 -1.0 -0.3 -1.1 0.1 -0.7 -0.6 -1.1 -0.8 -0.9
Ever had prostate specific antigen (PSA) test 1.0 1.1 2.7 0.6 0.9 0.8 -0.9 1.5 0.1 0.7 -0.7 -1.2 -1.3 -0.7 -1.1 -1.1 -1.5 -0.9 -1.0 -1.0 -1.2 -1.6 -1.3
Fractured/broken bones in last 5 years 0.3 0.4 1.1 -0.6 -0.7 -0.4 0.8 -0.9 0.0 -0.5 0.6 0.6 0.9 -0.2 0.9 1.0 0.7 0.6 0.6 0.5 -0.8 0.5 0.6
Age started oral contraceptive pill 1.4 1.8 7.1 0.8 0.7 0.4 -1.1 -1.0 -2.3 0.0 -2.5 -0.9 -2.3 -2.7 -1.1 -0.0 -1.2 0.6 -0.9 -0.7 -0.5 0.1 -1.5
Diastolic blood pressure, automated reading 0.4 1.2 4.4 -1.0 -1.4 -1.4 0.7 -1.2 -0.5 -1.5 0.5 -0.4 0.1 -0.9 0.7 1.1 0.3 1.5 1.3 1.3 2.1 0.8 0.6
Ever depressed for a whole week 0.1 0.1 0.4 0.0 -0.3 -0.4 0.0 -0.0 0.6 -0.2 -0.1 0.0 -0.3 -0.7 -0.3 -0.3 -0.1 -0.0 0.1 0.1 -0.1 -0.2 0.3
Unable to work because of sickness or disability 0.7 0.9 4.5 0.8 1.0 0.5 -0.6 1.2 -0.2 0.4 -1.1 -2.1 -0.9 -1.1 -0.7 -1.0 -0.6 -0.5 -0.6 -0.7 0.2 -1.2 -0.9
Commuting to job workplace: Cycle 1.0 1.2 3.1 1.1 1.2 0.8 -0.8 1.5 0.4 0.6 -0.4 1.8 -0.1 -1.4 -0.6 -0.7 -1.3 -0.4 -1.1 -1.1 -1.2 -1.5 -1.5
Myopia 3.0 4.3 7.0 -2.1 -2.3 -2.1 1.9 -2.4 2.0 -2.0 2.6 2.6 1.7 1.5 2.0 1.8 2.3 1.3 2.2 2.1 1.7 1.9 2.5
Vascular/heart problems diagnosed by doctor 2.2 5.9 15.1 2.4 2.6 3.1 -2.4 3.0 -0.1 3.5 -1.0 -2.4 0.3 0.7 -2.4 -3.1 -2.2 -3.9 -2.5 -2.6 -1.4 -3.1 -1.6
Cholesterol lowering medication 7.9 11.6 32.4 -3.4 -3.4 -3.3 4.0 -5.7 2.1 -4.2 1.9 4.1 0.5 -1.6 3.5 4.8 2.5 4.6 2.9 3.3 -1.1 3.9 2.2
Medication: Omeprazole (e.g. Zanprol) 4.8 5.9 10.9 -3.1 -2.9 -2.3 2.7 -1.2 3.3 -2.0 3.1 1.5 2.7 1.6 2.3 1.8 2.5 1.2 2.9 2.7 2.0 1.7 3.1
Pain experienced in last month 0.8 1.4 4.2 -1.2 -1.0 -1.3 1.1 -1.7 0.7 -1.6 0.1 1.4 0.2 0.6 1.2 1.6 0.8 2.1 0.8 0.9 0.3 1.7 0.6
Supplements: Calcium 0.5 0.5 2.4 -0.2 0.2 0.4 -0.1 -1.4 -0.9 0.1 -1.0 0.1 -0.6 -1.4 -0.3 0.5 -0.8 0.0 -0.3 -0.2 -1.5 -0.3 -0.6
Basal cell carcinoma (self-reported) 0.4 0.4 1.6 -0.4 -0.4 -0.5 0.3 0.4 -0.3 -0.6 0.0 1.0 0.2 1.3 0.7 1.2 0.4 1.0 0.2 0.4 -0.2 1.1 0.1
Heart attack/myocardial infarction (self-reported) 0.9 1.2 3.2 1.8 1.4 1.4 -0.5 0.2 0.4 1.2 -1.1 0.7 -0.2 -0.4 -0.8 -1.1 -0.9 -1.0 -1.4 -1.4 -1.3 -0.8 -1.4
Deep venous thrombosis (DVT) (self-reported) 0.7 0.8 3.3 0.6 0.8 0.5 -1.2 0.5 -1.5 0.5 -1.2 0.7 -1.8 -0.4 -1.3 -1.1 -1.0 -0.6 -0.8 -0.8 0.0 -0.3 -0.7
Heart disease (siblings) 0.3 0.4 2.8 -0.2 0.1 0.1 0.4 -0.6 1.5 -0.1 0.3 -0.5 -0.1 -1.7 -0.1 0.1 0.0 0.4 -0.4 -0.3 -0.6 0.5 -0.2
Alcohol drinker status: Previous 1.1 1.2 3.3 1.1 1.1 1.3 -1.0 1.0 1.1 1.5 -0.5 -0.4 0.3 1.5 -0.9 -1.4 -0.8 -1.8 -1.0 -1.1 -0.7 -1.7 -0.6
Pack years of smoking 2.0 2.9 7.6 -2.0 -1.8 -1.6 1.6 -1.6 1.2 -1.2 2.8 1.1 2.0 2.1 1.8 0.9 1.9 0.4 2.0 1.8 1.8 0.6 2.1
Impedance of whole body 0.2 0.9 6.4 0.8 0.8 0.5 -1.2 0.8 -2.5 0.4 -1.6 -0.2 -1.0 0.6 -0.7 -0.6 -0.6 0.0 -0.9 -0.8 -0.5 0.1 -0.9
Leg fat mass (left) 0.7 2.6 11.5 -0.6 -0.7 0.4 1.6 0.0 3.2 0.9 2.0 0.1 3.4 2.6 0.9 -0.6 1.4 -2.1 1.0 0.8 1.2 -0.5 1.9
Arm predicted mass (left) 0.1 0.4 1.9 -0.7 -0.7 -0.2 0.8 -0.4 1.4 -0.2 1.1 -0.3 0.8 0.1 0.3 0.3 0.1 -0.3 0.7 0.6 0.6 -0.2 0.6