[Hub]/) : Traits : Hypothyroidism (self reported) :

chr12:55,601,472-57,681,122

Best TWAS P=6.49e-18 · Best GWAS P=4.35e-15 conditioned to 0.0371

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex RPS26 0.48 0.62 lasso 5 0.63 5.9e-99 7.32 7.5 4.7e-14 0.82 0.18 0.82 FALSE
2 GTEx Artery Aorta SUOX 0.36 0.30 lasso 7 0.35 3.8e-20 7.50 -7.1 1.1e-12 -0.79 0.06 0.94 FALSE
3 GTEx Artery Tibial SUOX 0.18 0.14 enet 23 0.18 2.1e-14 7.48 -6.7 2.6e-11 -0.75 0.06 0.94 FALSE
4 GTEx Artery Tibial RPS26 0.07 0.02 enet 5 0.01 3.5e-02 7.32 7.4 1.1e-13 0.81 0.06 0.81 FALSE
5 GTEx Brain Cerebellum RBMS2 0.25 0.05 lasso 5 0.14 4.6e-05 2.10 5.6 2.1e-08 0.41 0.07 0.05 FALSE
6 GTEx Brain Cerebellum SUOX 0.24 0.20 lasso 6 0.20 1.2e-06 7.50 -6.9 4.5e-12 -0.75 0.06 0.90 FALSE
7 GTEx Brain Cortex SUOX 0.16 0.11 lasso 4 0.10 1.1e-03 7.50 -7.5 7.7e-14 -0.85 0.03 0.65 FALSE
8 GTEx Brain Nucleus accumbens basal ganglia SUOX 0.18 0.08 lasso 4 0.10 1.1e-03 7.50 -6.8 7.7e-12 -0.72 0.04 0.65 FALSE
9 GTEx Breast Mammary Tissue RPS26 0.29 0.05 enet 37 0.12 9.4e-07 7.32 6.0 2.5e-09 0.64 0.09 0.91 FALSE
10 GTEx Breast Mammary Tissue (Female) RPS26 0.20 0.11 lasso 3 0.10 6.6e-04 7.50 7.8 4.6e-15 0.82 0.04 0.39 FALSE
11 GTEx Cells Transformed fibroblasts RPS26 0.11 0.08 enet 15 0.09 3.4e-07 7.54 7.3 4.0e-13 0.74 0.06 0.94 FALSE
12 GTEx Colon Sigmoid SUOX 0.23 0.18 lasso 4 0.15 7.9e-06 7.50 -7.4 1.5e-13 -0.82 0.05 0.95 FALSE
13 GTEx Colon Transverse SUOX 0.24 0.22 enet 24 0.25 3.8e-12 7.50 -5.8 8.5e-09 -0.59 0.06 0.93 FALSE
14 GTEx Esophagus Gastroesophageal Junction SUOX 0.20 0.16 lasso 5 0.19 2.7e-07 7.48 -7.7 2.0e-14 -0.83 0.06 0.94 FALSE
15 GTEx Esophagus Gastroesophageal Junction WIBG 0.16 0.02 lasso 5 0.04 1.9e-02 0.15 -5.7 1.5e-08 -0.68 0.02 0.57 FALSE
16 GTEx Esophagus Muscularis SUOX 0.24 0.19 enet 16 0.15 2.3e-09 7.50 -8.2 3.0e-16 -0.81 0.06 0.94 FALSE
17 GTEx Esophagus Muscularis RPS26 0.19 0.06 enet 46 0.05 9.3e-04 7.32 5.4 5.5e-08 0.51 0.06 0.63 FALSE
18 GTEx Heart Atrial Appendage SUOX 0.09 0.10 enet 8 0.09 1.1e-04 7.32 -7.1 1.3e-12 -0.82 0.04 0.89 FALSE
19 GTEx Lung SUOX 0.34 0.23 enet 38 0.26 4.6e-20 7.50 -6.4 2.0e-10 -0.66 0.06 0.94 FALSE
20 GTEx Muscle Skeletal RAB5B 0.29 0.32 lasso 4 0.33 1.3e-33 7.71 -7.9 3.7e-15 -0.99 0.01 0.99 FALSE
21 GTEx Muscle Skeletal SUOX 0.11 0.04 lasso 7 0.04 4.4e-05 7.50 -7.0 2.1e-12 -0.82 0.06 0.93 FALSE
22 GTEx Muscle Skeletal AC034102.1 0.28 0.31 lasso 4 0.31 2.3e-31 7.84 -7.9 3.5e-15 -0.99 0.00 1.00 FALSE
23 GTEx Nerve Tibial SUOX 0.34 0.30 enet 22 0.35 8.5e-26 7.50 -7.1 1.7e-12 -0.70 0.06 0.94 FALSE
24 GTEx Nerve Tibial RPS26 0.12 0.09 enet 7 0.11 3.0e-08 6.58 6.8 1.4e-11 0.67 0.09 0.91 FALSE
25 GTEx Ovary SUOX 0.23 0.14 enet 12 0.21 8.4e-06 7.48 -8.6 6.5e-18 -0.75 0.06 0.61 TRUE
26 GTEx Ovary RPS26 0.50 0.24 enet 25 0.22 5.0e-06 7.46 7.1 1.0e-12 0.69 0.07 0.91 FALSE
27 GTEx Pancreas SUOX 0.30 0.20 enet 23 0.30 3.5e-13 7.48 -6.1 1.3e-09 -0.63 0.07 0.93 FALSE
28 GTEx Pituitary SUOX 0.44 0.13 enet 20 0.27 1.4e-07 7.54 -6.1 1.0e-09 -0.44 0.05 0.68 FALSE
29 GTEx Prostate SUOX 0.22 0.04 enet 11 0.05 2.3e-02 7.48 -8.0 1.1e-15 -0.88 0.03 0.83 FALSE
30 GTEx Skin Not Sun Exposed Suprapubic SUOX 0.10 0.14 lasso 2 0.12 2.5e-07 7.50 -7.5 6.0e-14 -0.85 0.04 0.96 FALSE
31 GTEx Skin Sun Exposed Lower leg SUOX 0.23 0.30 lasso 3 0.29 1.9e-24 7.50 -7.6 2.5e-14 -0.87 0.06 0.94 FALSE
32 GTEx Spleen SUOX 0.34 0.31 enet 15 0.28 5.4e-08 7.50 -6.3 3.0e-10 -0.74 0.06 0.90 FALSE
33 GTEx Stomach SUOX 0.15 0.17 enet 8 0.09 6.7e-05 7.50 -7.3 2.2e-13 -0.84 0.06 0.94 FALSE
34 GTEx Stomach RPS26 0.16 0.08 enet 5 0.05 1.8e-03 7.50 5.8 6.3e-09 0.76 0.06 0.70 FALSE
35 GTEx Testis SUOX 0.27 0.18 lasso 14 0.18 1.4e-08 7.50 -7.7 1.2e-14 -0.85 0.05 0.95 FALSE
36 GTEx Thyroid SUOX 0.37 0.40 lasso 7 0.38 5.4e-31 7.50 -7.5 4.5e-14 -0.84 0.06 0.94 FALSE
37 GTEx Whole Blood SUOX 0.07 0.01 enet 20 0.02 1.1e-02 7.32 -7.0 3.4e-12 -0.73 0.03 0.91 FALSE
38 GTEx Whole Blood RPS26 0.05 0.05 lasso 1 0.05 3.4e-05 7.48 7.5 7.7e-14 0.86 0.03 0.96 FALSE
39 METSIM Adipose IKZF4 0.04 0.04 enet 3 0.04 1.0e-06 7.46 7.5 7.2e-14 0.77 0.07 0.93 FALSE
40 METSIM Adipose RPS26 0.30 0.40 lasso 5 0.41 7.2e-66 7.54 7.5 7.3e-14 0.78 0.06 0.94 FALSE
41 METSIM Adipose SUOX 0.04 0.01 blup 288 0.02 1.1e-03 7.46 -5.7 1.0e-08 -0.53 0.09 0.87 FALSE
42 YFS Blood SUOX 0.11 0.09 bslmm 269 0.09 3.4e-27 7.48 -7.5 8.1e-14 -0.82 0.06 0.94 FALSE
43 The Cancer Genome Atlas Bladder Urothelial Carcinoma RPS26 0.14 0.22 lasso 2 0.23 4.8e-19 7.54 7.5 5.3e-14 0.78 0.03 0.97 FALSE
44 The Cancer Genome Atlas Breast Invasive Carcinoma RPS26 0.30 0.44 enet 10 0.45 5.2e-104 7.32 7.8 8.6e-15 0.84 0.10 0.90 FALSE
45 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma RPS26 0.23 0.40 lasso 2 0.39 1.5e-20 7.32 7.5 6.5e-14 0.83 0.07 0.93 FALSE
46 The Cancer Genome Atlas Colon Adenocarcinoma RPS26 0.43 0.48 lasso 4 0.47 1.8e-30 7.32 7.5 4.3e-14 0.84 0.10 0.90 FALSE
47 The Cancer Genome Atlas Esophageal Carcinoma RPS26 0.19 0.13 lasso 5 0.11 2.4e-04 7.32 7.5 7.9e-14 0.83 0.01 0.96 FALSE
48 The Cancer Genome Atlas Glioblastoma Multiforme RPS26 0.41 0.38 enet 9 0.39 7.9e-13 7.54 7.6 4.0e-14 0.80 0.03 0.97 FALSE
49 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma RPS26 0.17 0.29 lasso 4 0.29 6.2e-33 7.54 7.5 5.0e-14 0.79 0.03 0.97 FALSE
50 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma RPS26 0.50 0.45 enet 13 0.52 1.4e-67 7.54 6.9 5.7e-12 0.72 0.03 0.97 FALSE
51 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma RPS26 0.27 0.38 enet 8 0.40 5.0e-24 7.32 7.7 1.9e-14 0.85 0.07 0.93 FALSE
52 The Cancer Genome Atlas Brain Lower Grade Glioma ERBB3 0.07 0.02 blup 29 0.05 2.1e-06 7.74 5.6 1.7e-08 0.74 0.00 0.99 FALSE
53 The Cancer Genome Atlas Brain Lower Grade Glioma RPS26 0.31 0.53 enet 8 0.55 1.7e-74 7.32 7.7 1.4e-14 0.83 0.05 0.95 FALSE
54 The Cancer Genome Atlas Brain Lower Grade Glioma SUOX 0.09 0.04 blup 28 0.03 1.3e-04 1.35 -5.2 2.4e-07 -0.27 0.11 0.15 FALSE
55 The Cancer Genome Atlas Liver Hepatocellular Carcinoma RPS26 0.18 0.31 lasso 2 0.29 3.9e-14 7.32 7.3 2.7e-13 0.79 0.06 0.94 FALSE
56 The Cancer Genome Atlas Lung Adenocarcinoma RAB5B 0.03 0.02 enet 7 0.02 4.3e-03 7.71 6.3 3.3e-10 0.83 0.00 0.84 FALSE
57 The Cancer Genome Atlas Lung Adenocarcinoma RPS26 0.26 0.45 enet 9 0.47 3.6e-61 7.32 7.7 9.7e-15 0.85 0.05 0.95 FALSE
58 The Cancer Genome Atlas Lung Squamous Cell Carcinoma RPS26 0.22 0.31 lasso 3 0.31 1.6e-35 7.32 7.6 4.0e-14 0.84 0.10 0.90 FALSE
59 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma RPS26 0.30 0.20 lasso 4 0.24 3.9e-16 7.32 7.9 3.4e-15 0.91 0.02 0.98 FALSE
60 The Cancer Genome Atlas Pancreatic Adenocarcinoma RPS26 0.36 0.44 lasso 7 0.42 2.4e-19 7.54 7.5 5.0e-14 0.80 0.03 0.97 FALSE
61 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma RPS26 0.47 0.43 lasso 2 0.44 3.2e-19 7.48 7.5 5.2e-14 0.85 0.04 0.96 FALSE
62 The Cancer Genome Atlas Prostate Adenocarcinoma RPS26 0.33 0.52 enet 9 0.54 5.6e-66 7.32 7.7 2.0e-14 0.84 0.08 0.92 FALSE
63 The Cancer Genome Atlas Rectum Adenocarcinoma RPS26 0.24 0.18 lasso 2 0.20 1.9e-05 7.32 7.5 8.0e-14 0.83 0.02 0.78 FALSE
64 The Cancer Genome Atlas Soft Tissue Sarcoma RPS26 0.23 0.31 lasso 3 0.30 2.4e-18 7.32 7.4 1.3e-13 0.81 0.08 0.92 FALSE
65 The Cancer Genome Atlas Skin Cutaneous Melanoma RPS26 0.28 0.15 lasso 2 0.17 3.0e-05 7.84 8.0 1.5e-15 0.98 0.00 0.98 FALSE
66 The Cancer Genome Atlas Stomach Adenocarcinoma RPS26 0.19 0.32 lasso 5 0.34 2.0e-25 7.54 7.6 3.5e-14 0.80 0.03 0.97 FALSE
67 The Cancer Genome Atlas Testicular Germ Cell Tumors RPS26 0.46 0.64 lasso 4 0.65 8.5e-30 7.32 7.6 4.2e-14 0.83 0.04 0.96 FALSE
68 The Cancer Genome Atlas Thyroid Carcinoma RPS26 0.33 0.51 enet 19 0.50 7.3e-56 7.32 6.7 2.3e-11 0.77 0.09 0.91 FALSE
69 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma RPS26 0.17 0.19 lasso 4 0.18 1.3e-05 7.32 7.5 4.4e-14 0.85 0.02 0.97 FALSE