[Hub]/) : Traits : Hypothyroidism (self reported) : ← →

chr12:55,601,472-57,681,122

Best TWAS P=6.49e-18 · Best GWAS P=4.35e-15 conditioned to 0.0371

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RPS26	0.48	0.62	lasso	5	0.63	5.9e-99	7.32	7.5	4.7e-14	0.82	0.18	0.82	FALSE
2	GTEx	Artery Aorta	SUOX	0.36	0.30	lasso	7	0.35	3.8e-20	7.50	-7.1	1.1e-12	-0.79	0.06	0.94	FALSE
3	GTEx	Artery Tibial	SUOX	0.18	0.14	enet	23	0.18	2.1e-14	7.48	-6.7	2.6e-11	-0.75	0.06	0.94	FALSE
4	GTEx	Artery Tibial	RPS26	0.07	0.02	enet	5	0.01	3.5e-02	7.32	7.4	1.1e-13	0.81	0.06	0.81	FALSE
5	GTEx	Brain Cerebellum	RBMS2	0.25	0.05	lasso	5	0.14	4.6e-05	2.10	5.6	2.1e-08	0.41	0.07	0.05	FALSE
6	GTEx	Brain Cerebellum	SUOX	0.24	0.20	lasso	6	0.20	1.2e-06	7.50	-6.9	4.5e-12	-0.75	0.06	0.90	FALSE
7	GTEx	Brain Cortex	SUOX	0.16	0.11	lasso	4	0.10	1.1e-03	7.50	-7.5	7.7e-14	-0.85	0.03	0.65	FALSE
8	GTEx	Brain Nucleus accumbens basal ganglia	SUOX	0.18	0.08	lasso	4	0.10	1.1e-03	7.50	-6.8	7.7e-12	-0.72	0.04	0.65	FALSE
9	GTEx	Breast Mammary Tissue	RPS26	0.29	0.05	enet	37	0.12	9.4e-07	7.32	6.0	2.5e-09	0.64	0.09	0.91	FALSE
10	GTEx	Breast Mammary Tissue (Female)	RPS26	0.20	0.11	lasso	3	0.10	6.6e-04	7.50	7.8	4.6e-15	0.82	0.04	0.39	FALSE
11	GTEx	Cells Transformed fibroblasts	RPS26	0.11	0.08	enet	15	0.09	3.4e-07	7.54	7.3	4.0e-13	0.74	0.06	0.94	FALSE
12	GTEx	Colon Sigmoid	SUOX	0.23	0.18	lasso	4	0.15	7.9e-06	7.50	-7.4	1.5e-13	-0.82	0.05	0.95	FALSE
13	GTEx	Colon Transverse	SUOX	0.24	0.22	enet	24	0.25	3.8e-12	7.50	-5.8	8.5e-09	-0.59	0.06	0.93	FALSE
14	GTEx	Esophagus Gastroesophageal Junction	SUOX	0.20	0.16	lasso	5	0.19	2.7e-07	7.48	-7.7	2.0e-14	-0.83	0.06	0.94	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	WIBG	0.16	0.02	lasso	5	0.04	1.9e-02	0.15	-5.7	1.5e-08	-0.68	0.02	0.57	FALSE
16	GTEx	Esophagus Muscularis	SUOX	0.24	0.19	enet	16	0.15	2.3e-09	7.50	-8.2	3.0e-16	-0.81	0.06	0.94	FALSE
17	GTEx	Esophagus Muscularis	RPS26	0.19	0.06	enet	46	0.05	9.3e-04	7.32	5.4	5.5e-08	0.51	0.06	0.63	FALSE
18	GTEx	Heart Atrial Appendage	SUOX	0.09	0.10	enet	8	0.09	1.1e-04	7.32	-7.1	1.3e-12	-0.82	0.04	0.89	FALSE
19	GTEx	Lung	SUOX	0.34	0.23	enet	38	0.26	4.6e-20	7.50	-6.4	2.0e-10	-0.66	0.06	0.94	FALSE
20	GTEx	Muscle Skeletal	RAB5B	0.29	0.32	lasso	4	0.33	1.3e-33	7.71	-7.9	3.7e-15	-0.99	0.01	0.99	FALSE
21	GTEx	Muscle Skeletal	SUOX	0.11	0.04	lasso	7	0.04	4.4e-05	7.50	-7.0	2.1e-12	-0.82	0.06	0.93	FALSE
22	GTEx	Muscle Skeletal	AC034102.1	0.28	0.31	lasso	4	0.31	2.3e-31	7.84	-7.9	3.5e-15	-0.99	0.00	1.00	FALSE
23	GTEx	Nerve Tibial	SUOX	0.34	0.30	enet	22	0.35	8.5e-26	7.50	-7.1	1.7e-12	-0.70	0.06	0.94	FALSE
24	GTEx	Nerve Tibial	RPS26	0.12	0.09	enet	7	0.11	3.0e-08	6.58	6.8	1.4e-11	0.67	0.09	0.91	FALSE
25	GTEx	Ovary	SUOX	0.23	0.14	enet	12	0.21	8.4e-06	7.48	-8.6	6.5e-18	-0.75	0.06	0.61	TRUE
26	GTEx	Ovary	RPS26	0.50	0.24	enet	25	0.22	5.0e-06	7.46	7.1	1.0e-12	0.69	0.07	0.91	FALSE
27	GTEx	Pancreas	SUOX	0.30	0.20	enet	23	0.30	3.5e-13	7.48	-6.1	1.3e-09	-0.63	0.07	0.93	FALSE
28	GTEx	Pituitary	SUOX	0.44	0.13	enet	20	0.27	1.4e-07	7.54	-6.1	1.0e-09	-0.44	0.05	0.68	FALSE
29	GTEx	Prostate	SUOX	0.22	0.04	enet	11	0.05	2.3e-02	7.48	-8.0	1.1e-15	-0.88	0.03	0.83	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	SUOX	0.10	0.14	lasso	2	0.12	2.5e-07	7.50	-7.5	6.0e-14	-0.85	0.04	0.96	FALSE
31	GTEx	Skin Sun Exposed Lower leg	SUOX	0.23	0.30	lasso	3	0.29	1.9e-24	7.50	-7.6	2.5e-14	-0.87	0.06	0.94	FALSE
32	GTEx	Spleen	SUOX	0.34	0.31	enet	15	0.28	5.4e-08	7.50	-6.3	3.0e-10	-0.74	0.06	0.90	FALSE
33	GTEx	Stomach	SUOX	0.15	0.17	enet	8	0.09	6.7e-05	7.50	-7.3	2.2e-13	-0.84	0.06	0.94	FALSE
34	GTEx	Stomach	RPS26	0.16	0.08	enet	5	0.05	1.8e-03	7.50	5.8	6.3e-09	0.76	0.06	0.70	FALSE
35	GTEx	Testis	SUOX	0.27	0.18	lasso	14	0.18	1.4e-08	7.50	-7.7	1.2e-14	-0.85	0.05	0.95	FALSE
36	GTEx	Thyroid	SUOX	0.37	0.40	lasso	7	0.38	5.4e-31	7.50	-7.5	4.5e-14	-0.84	0.06	0.94	FALSE
37	GTEx	Whole Blood	SUOX	0.07	0.01	enet	20	0.02	1.1e-02	7.32	-7.0	3.4e-12	-0.73	0.03	0.91	FALSE
38	GTEx	Whole Blood	RPS26	0.05	0.05	lasso	1	0.05	3.4e-05	7.48	7.5	7.7e-14	0.86	0.03	0.96	FALSE
39	METSIM	Adipose	IKZF4	0.04	0.04	enet	3	0.04	1.0e-06	7.46	7.5	7.2e-14	0.77	0.07	0.93	FALSE
40	METSIM	Adipose	RPS26	0.30	0.40	lasso	5	0.41	7.2e-66	7.54	7.5	7.3e-14	0.78	0.06	0.94	FALSE
41	METSIM	Adipose	SUOX	0.04	0.01	blup	288	0.02	1.1e-03	7.46	-5.7	1.0e-08	-0.53	0.09	0.87	FALSE
42	YFS	Blood	SUOX	0.11	0.09	bslmm	269	0.09	3.4e-27	7.48	-7.5	8.1e-14	-0.82	0.06	0.94	FALSE
43	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RPS26	0.14	0.22	lasso	2	0.23	4.8e-19	7.54	7.5	5.3e-14	0.78	0.03	0.97	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPS26	0.30	0.44	enet	10	0.45	5.2e-104	7.32	7.8	8.6e-15	0.84	0.10	0.90	FALSE
45	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	RPS26	0.23	0.40	lasso	2	0.39	1.5e-20	7.32	7.5	6.5e-14	0.83	0.07	0.93	FALSE
46	The Cancer Genome Atlas	Colon Adenocarcinoma	RPS26	0.43	0.48	lasso	4	0.47	1.8e-30	7.32	7.5	4.3e-14	0.84	0.10	0.90	FALSE
47	The Cancer Genome Atlas	Esophageal Carcinoma	RPS26	0.19	0.13	lasso	5	0.11	2.4e-04	7.32	7.5	7.9e-14	0.83	0.01	0.96	FALSE
48	The Cancer Genome Atlas	Glioblastoma Multiforme	RPS26	0.41	0.38	enet	9	0.39	7.9e-13	7.54	7.6	4.0e-14	0.80	0.03	0.97	FALSE
49	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RPS26	0.17	0.29	lasso	4	0.29	6.2e-33	7.54	7.5	5.0e-14	0.79	0.03	0.97	FALSE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RPS26	0.50	0.45	enet	13	0.52	1.4e-67	7.54	6.9	5.7e-12	0.72	0.03	0.97	FALSE
51	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RPS26	0.27	0.38	enet	8	0.40	5.0e-24	7.32	7.7	1.9e-14	0.85	0.07	0.93	FALSE
52	The Cancer Genome Atlas	Brain Lower Grade Glioma	ERBB3	0.07	0.02	blup	29	0.05	2.1e-06	7.74	5.6	1.7e-08	0.74	0.00	0.99	FALSE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	RPS26	0.31	0.53	enet	8	0.55	1.7e-74	7.32	7.7	1.4e-14	0.83	0.05	0.95	FALSE
54	The Cancer Genome Atlas	Brain Lower Grade Glioma	SUOX	0.09	0.04	blup	28	0.03	1.3e-04	1.35	-5.2	2.4e-07	-0.27	0.11	0.15	FALSE
55	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	RPS26	0.18	0.31	lasso	2	0.29	3.9e-14	7.32	7.3	2.7e-13	0.79	0.06	0.94	FALSE
56	The Cancer Genome Atlas	Lung Adenocarcinoma	RAB5B	0.03	0.02	enet	7	0.02	4.3e-03	7.71	6.3	3.3e-10	0.83	0.00	0.84	FALSE
57	The Cancer Genome Atlas	Lung Adenocarcinoma	RPS26	0.26	0.45	enet	9	0.47	3.6e-61	7.32	7.7	9.7e-15	0.85	0.05	0.95	FALSE
58	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RPS26	0.22	0.31	lasso	3	0.31	1.6e-35	7.32	7.6	4.0e-14	0.84	0.10	0.90	FALSE
59	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RPS26	0.30	0.20	lasso	4	0.24	3.9e-16	7.32	7.9	3.4e-15	0.91	0.02	0.98	FALSE
60	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RPS26	0.36	0.44	lasso	7	0.42	2.4e-19	7.54	7.5	5.0e-14	0.80	0.03	0.97	FALSE
61	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RPS26	0.47	0.43	lasso	2	0.44	3.2e-19	7.48	7.5	5.2e-14	0.85	0.04	0.96	FALSE
62	The Cancer Genome Atlas	Prostate Adenocarcinoma	RPS26	0.33	0.52	enet	9	0.54	5.6e-66	7.32	7.7	2.0e-14	0.84	0.08	0.92	FALSE
63	The Cancer Genome Atlas	Rectum Adenocarcinoma	RPS26	0.24	0.18	lasso	2	0.20	1.9e-05	7.32	7.5	8.0e-14	0.83	0.02	0.78	FALSE
64	The Cancer Genome Atlas	Soft Tissue Sarcoma	RPS26	0.23	0.31	lasso	3	0.30	2.4e-18	7.32	7.4	1.3e-13	0.81	0.08	0.92	FALSE
65	The Cancer Genome Atlas	Skin Cutaneous Melanoma	RPS26	0.28	0.15	lasso	2	0.17	3.0e-05	7.84	8.0	1.5e-15	0.98	0.00	0.98	FALSE
66	The Cancer Genome Atlas	Stomach Adenocarcinoma	RPS26	0.19	0.32	lasso	5	0.34	2.0e-25	7.54	7.6	3.5e-14	0.80	0.03	0.97	FALSE
67	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RPS26	0.46	0.64	lasso	4	0.65	8.5e-30	7.32	7.6	4.2e-14	0.83	0.04	0.96	FALSE
68	The Cancer Genome Atlas	Thyroid Carcinoma	RPS26	0.33	0.51	enet	19	0.50	7.3e-56	7.32	6.7	2.3e-11	0.77	0.09	0.91	FALSE
69	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	RPS26	0.17	0.19	lasso	4	0.18	1.3e-05	7.32	7.5	4.4e-14	0.85	0.02	0.97	FALSE