TWAS
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Traits
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Traits
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Hypothyroidism (self reported)
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chr17:27,222,988-28,629,763
Best TWAS P=9.51e-08 · Best GWAS P=1.71e-06 conditioned to 0.0172
27.2M
27.4M
27.6M
27.8M
28M
28.2M
28.4M
28.6M
0
1
2
3
4
5
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
The Cancer Genome Atlas
Thyroid Carcinoma
ABHD15
0.06
0.03
blup
44
0.03
1.1e-03
3.1
-5.3
9.5e-08
0.51
0.00
0.15
TRUE
1
GTEx
Thyroid
ANKRD13B
0.23
0.12
lasso
6
0.18
2.3e-13
-4.8
-5.2
2.0e-07
0.82
0.01
0.97
FALSE