TWAS hub - ABHD15

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0740	0.0330	3.8e-04	0.034	0.034	0.032	0.035	0.035	4.5e-05	5.2e-05	8.6e-05	3.4e-05	3.5e-05
2	GTEx	Artery Aorta	0.2030	0.0740	8.9e-04	0.027	NA	0.061	NA	0.052	1.2e-02	NA	2.9e-04	NA	7.5e-04
3	GTEx	Brain Cerebellum	0.2640	0.1120	3.5e-03	0.013	NA	0.030	NA	0.049	1.3e-01	NA	4.6e-02	NA	1.4e-02
4	GTEx	Esophagus Mucosa	0.2130	0.0810	1.3e-03	0.128	NA	0.044	NA	0.105	7.4e-09	NA	6.0e-04	NA	1.7e-07
5	GTEx	Spleen	0.2840	0.1200	2.2e-03	0.096	NA	0.087	NA	0.166	1.9e-03	NA	3.0e-03	NA	5.0e-05
6	METSIM	Adipose	0.0741	0.0330	2.2e-05	0.058	0.038	0.044	0.047	0.057	4.9e-09	1.8e-06	3.0e-07	1.1e-07	6.1e-09
7	YFS	Blood	0.2473	0.0418	0.0e+00	0.165	0.136	0.164	0.160	0.166	9.6e-52	3.9e-42	3.4e-51	4.6e-50	8.4e-52
8	TCGA	Breast Invasive Carcinoma	0.0355	0.0174	3.6e-04	0.026	0.019	0.021	NA	0.023	3.5e-06	5.5e-05	3.0e-05	NA	1.4e-05
9	TCGA	Prostate Adenocarcinoma	0.1080	0.0382	5.1e-09	0.081	0.079	0.086	NA	0.090	7.4e-09	1.2e-08	3.0e-09	NA	1.1e-09
10	TCGA	Thyroid Carcinoma	0.0550	0.0270	3.6e-03	0.033	0.027	0.012	NA	0.016	3.4e-04	1.1e-03	2.0e-02	NA	8.7e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Blood Platelet Count	12.1	140.0	372.5	19.3	1.8	-0.7	8.3	18.2	14.0	10.6	8.5	10.5	11.5
Bipolar Disorder (2011)	6.9	6.6	13.1	-1.6	-1.2	0.7	-3.4	-2.5	-3.4	-3.0	-3.6	-3.2	-0.2
Bipolar Disorder (2018)	5.8	9.2	14.6	-2.8	-1.5	-1.3	-3.7	-3.3	-3.5	-3.6	-3.6	-3.8	-1.8
Prospective memory result	5.0	6.2	12.7	-2.2	-1.8	0.8	-2.7	-2.3	-3.6	-3.1	-2.9	-3.0	-0.9
Supplements: Calcium	4.8	5.3	9.3	2.3	2.2	3.1	2.7	2.1	1.8	2.2	2.5	2.4	1.6
Tinnitus: Yes, but not now, but have in the past	4.7	5.0	8.7	2.0	1.1	1.2	2.9	2.1	2.1	2.6	2.9	2.8	1.8
Ever had bowel cancer screening	4.7	5.5	8.8	2.0	2.2	0.1	2.8	2.5	2.8	2.6	3.0	2.9	0.6
Height	4.4	84.4	185.0	-8.8	-13.6	-4.1	-11.5	-6.5	-7.5	-8.4	-12.6	-9.7	-3.4
Pack years adult smoking proportion	4.2	6.5	11.4	-2.8	-2.0	-0.8	-2.5	-3.1	-2.5	-2.6	-2.1	-2.8	-3.4
Pack years of smoking	4.0	5.9	11.3	-2.3	-2.3	-0.8	-2.5	-2.8	-2.2	-2.5	-2.0	-2.7	-3.4
Lung FEV1/FVC ratio	3.9	19.8	40.4	2.8	1.6	-5.2	4.3	3.4	6.0	2.8	6.4	3.4	-5.9
Supplements: Zinc	3.9	4.2	9.4	3.1	1.1	1.8	1.9	2.3	2.2	2.1	2.2	2.1	0.9
Medication: Metformin	3.9	5.5	10.6	3.2	-0.0	0.3	2.4	3.0	2.7	2.4	2.8	2.6	1.1
Comparative height size at age 10	3.9	21.6	62.7	-2.9	-7.9	-1.5	-6.4	-1.7	-3.4	-4.0	-7.0	-4.9	-0.6
Trunk fat-free mass	3.8	21.9	70.6	-1.9	-8.4	-1.0	-6.1	-2.3	-3.2	-4.4	-6.2	-5.1	-2.5
Trunk predicted mass	3.7	21.3	69.7	-1.9	-8.3	-1.0	-6.0	-2.2	-3.1	-4.3	-6.2	-5.0	-2.5
Schizophrenia vs Biploar Disorder	3.6	4.7	7.7	1.9	0.6	1.9	2.4	2.0	2.8	2.7	2.5	2.7	1.1
Cholesterol lowering medication	3.6	5.3	10.9	3.2	-0.2	-0.0	2.0	2.1	3.3	2.1	2.9	2.2	-2.2
Whole body fat-free mass	3.5	20.3	62.9	-2.1	-7.9	-1.2	-5.8	-2.2	-3.1	-4.3	-5.9	-5.0	-2.6
Whole body water mass	3.4	19.1	61.0	-1.9	-7.8	-1.1	-5.7	-2.1	-3.0	-4.2	-5.7	-4.9	-2.5
Standing height	3.3	32.6	79.2	-4.1	-8.9	-1.8	-7.8	-2.6	-4.5	-4.9	-8.8	-6.0	-0.2
Birth weight	3.3	7.2	13.6	-1.5	-2.9	-0.4	-2.9	-2.6	-3.7	-3.4	-3.2	-3.3	-0.5
Arm fat-free mass (right)	3.3	17.0	61.5	-1.8	-7.8	-1.1	-5.1	-1.9	-2.5	-3.8	-5.0	-4.4	-3.1
Hayfever/allergic rhinitis (self-reported)	3.2	4.2	6.2	2.3	1.7	0.7	2.5	2.1	2.0	2.1	2.5	2.3	1.9
Forced expiratory volume in 1-second (FEV1), predicted	3.2	6.6	14.7	-1.8	-3.8	-1.5	-3.4	-1.6	-2.2	-2.2	-3.8	-2.8	-0.1
Basal metabolic rate	3.2	17.8	60.4	-1.9	-7.8	-1.3	-5.3	-1.9	-2.7	-4.0	-5.3	-4.6	-2.7
Arm predicted mass (left)	3.2	16.4	61.6	-1.3	-7.8	-0.8	-5.0	-2.0	-2.4	-3.7	-4.8	-4.3	-3.1
Breastfed as a baby	3.1	3.9	5.8	1.7	1.1	0.9	2.3	2.1	2.3	2.4	2.3	2.4	1.1
Arm predicted mass (right)	3.1	15.9	58.7	-1.5	-7.7	-0.7	-5.0	-1.9	-2.4	-3.6	-4.9	-4.2	-3.0
Arm fat-free mass (left)	3.1	15.8	59.4	-1.4	-7.7	-0.7	-4.8	-2.0	-2.4	-3.7	-4.7	-4.3	-2.9
Leg fat-free mass (right)	3.0	16.0	43.4	-2.1	-6.6	-1.4	-5.2	-1.7	-3.1	-4.0	-5.4	-4.6	-1.8
Age started oral contraceptive pill	3.0	3.7	9.7	3.1	-0.6	1.9	1.4	2.6	2.1	1.8	1.5	1.9	1.2
Ulcerative Colitis (UC)	2.9	5.5	11.6	2.7	1.7	0.5	2.0	3.4	2.8	2.5	2.3	2.6	1.6
Leg fat-free mass (left)	2.9	15.2	43.6	-2.2	-6.6	-1.8	-5.0	-1.7	-2.6	-3.8	-5.0	-4.4	-2.6
High blood pressure (mother)	2.9	4.1	11.4	-1.8	-2.1	-3.4	-1.5	-1.5	-1.1	-1.9	-1.0	-1.8	-2.9
Leg predicted mass (left)	2.9	15.5	44.1	-2.2	-6.6	-1.7	-5.1	-1.7	-2.6	-3.9	-5.0	-4.5	-2.6
Hearing difficulty/problems with background noise	2.9	4.6	8.7	2.1	2.8	1.8	2.9	1.4	0.9	1.6	2.9	2.1	2.0
Leg predicted mass (right)	2.9	15.6	42.6	-2.2	-6.5	-1.3	-5.2	-1.7	-3.0	-4.0	-5.3	-4.6	-1.7
Medication: Ibuprofen	2.8	3.4	5.1	-1.7	-1.7	-1.0	-1.7	-1.9	-2.3	-2.3	-1.7	-2.2	-1.5
Forced vital capacity (FVC), Best measure	2.7	10.0	22.1	-1.9	-2.8	0.4	-4.0	-2.7	-4.1	-3.5	-4.7	-3.7	0.8
Hearing difficulty/problems: Yes	2.6	3.9	10.8	1.6	3.3	0.3	2.1	2.1	1.6	1.8	2.2	1.9	1.6
Forced vital capacity (FVC)	2.6	10.2	25.1	-1.7	-3.3	0.5	-4.1	-2.4	-3.8	-3.3	-5.0	-3.6	1.1
Qualifications: nursing, teaching	2.6	4.1	8.6	2.0	0.7	0.3	1.9	2.9	2.4	2.4	1.9	2.4	1.7
Heart disease (siblings)	2.6	3.1	6.1	2.1	0.2	1.4	1.7	1.5	2.5	1.8	2.1	1.9	-1.6
Number of incorrect matches in round	2.5	4.2	10.2	-0.1	-1.9	1.5	-2.7	-0.8	-2.4	-2.2	-3.2	-2.4	1.1
Alcohol intake frequency.	2.5	5.9	17.6	-4.2	-1.6	0.8	-2.8	-2.3	-2.1	-2.2	-2.6	-2.5	-1.6
Chest pain or discomfort	2.5	3.6	10.1	1.4	1.8	0.6	2.6	1.2	2.0	1.7	3.2	2.0	-1.2
Mouth/teeth dental problems: Mouth ulcers	2.5	3.9	8.0	0.9	2.4	1.6	2.8	1.0	1.7	2.0	2.8	2.4	0.5
Eye problems/disorders: Cataract	2.4	2.8	5.0	2.2	-1.6	0.0	1.3	2.2	2.2	1.9	1.4	1.8	0.4
Allergy	2.3	5.2	9.1	-2.0	-2.1	-1.5	-2.9	-2.0	-2.5	-2.4	-3.0	-2.6	-1.0
Medication: Ibuprofen (e.g. Nurofen)	2.3	2.9	5.7	-1.0	-1.6	-1.2	-1.5	-1.7	-2.4	-2.2	-1.6	-2.2	-1.0
Qualifications: College or University degree	2.3	7.1	10.9	3.0	2.2	-0.6	2.4	3.3	3.0	3.2	2.0	3.0	2.7
Blood White Count	2.2	16.3	33.2	-5.8	-0.0	-2.2	-3.8	-4.0	-5.6	-4.1	-5.0	-4.2	1.8
Sitting height	2.2	15.5	27.1	-3.6	-4.8	-2.0	-4.9	-3.2	-3.6	-3.9	-5.2	-4.5	-2.0
Weight	2.2	10.6	47.7	-1.0	-6.9	-1.5	-3.6	-1.1	-1.2	-2.8	-3.3	-3.2	-3.1
Illnesses of father: Heart disease	2.2	3.1	6.3	2.2	1.3	0.1	1.9	2.5	2.0	1.6	2.2	1.8	0.4
Heel T-Score	2.1	16.6	83.7	6.3	1.1	4.5	-0.1	3.4	-0.6	1.6	-2.2	1.0	9.2
Hypothyroidism (self reported)	2.1	4.9	28.5	-2.7	1.0	-2.3	-0.2	-2.3	0.3	-0.6	0.8	-0.5	-5.3
Diabetes diagnosed by doctor	2.1	3.4	6.8	2.4	0.6	-0.4	1.8	2.6	2.2	1.8	2.3	2.0	0.8
Osteoporosis (self-reported)	2.1	2.6	5.5	2.3	1.1	1.2	1.4	1.7	1.6	1.8	1.3	1.7	1.4
Average weekly champagne plus white wine intake	2.1	2.8	7.7	2.0	0.6	1.0	2.8	0.8	1.0	1.5	2.6	2.1	0.6
Age at First Birth	2.0	2.8	6.6	1.6	0.2	-2.1	1.4	2.6	1.8	1.7	1.4	1.7	1.3
Diabetes (self-reported)	2.0	3.1	6.3	2.2	0.6	-0.7	1.8	2.5	2.0	1.6	2.3	1.8	0.5
Age at first live birth	2.0	3.6	7.6	2.5	2.0	-0.6	1.3	2.8	2.0	1.9	1.4	1.9	1.7
Medication: Blood pressure	2.0	3.6	8.0	1.3	-1.0	-2.0	1.4	2.3	2.8	1.9	2.1	1.8	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.3	3.9	1.6	0.1	0.8	1.8	1.3	2.0	1.8	1.8	1.9	0.6
Hayfever, allergic rhinitis or eczema	1.9	4.2	7.5	1.6	1.3	0.7	2.5	1.7	2.7	2.4	2.7	2.6	0.4
Number of self-reported non-cancer illnesses	1.9	3.2	7.7	1.6	0.3	0.2	2.2	1.0	2.4	1.6	2.8	1.9	-2.1
Irritable Bowel Disease (IBD)	1.8	4.4	7.1	2.2	1.2	1.5	1.9	2.7	2.5	2.4	1.9	2.4	2.0
Fasting Glucose	1.8	2.1	6.5	-0.3	-2.5	-1.9	-1.9	-0.1	-0.8	-1.1	-2.1	-1.3	0.2
Maternal smoking around birth	1.8	2.6	4.2	-1.9	-1.2	0.8	-1.7	-2.0	-1.8	-1.6	-1.6	-1.7	-1.2
Hip circumference	1.8	7.6	37.8	-1.3	-6.2	-1.8	-2.7	-0.7	-0.5	-2.0	-2.3	-2.4	-3.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.3	3.8	0.7	1.9	1.4	1.9	0.5	1.5	1.8	1.8	1.9	0.3
Medication: Gliclazide	1.8	2.0	6.0	2.5	-1.6	0.6	0.7	2.1	1.7	0.9	1.0	1.0	0.3
Medication: Lisinopril	1.8	2.3	4.7	1.3	-1.8	-1.8	0.9	2.2	2.1	1.3	1.3	1.4	-0.3
Unable to work because of sickness or disability	1.8	2.3	8.7	-3.0	0.2	-0.4	-0.9	-2.2	-1.6	-1.3	-1.0	-1.2	-1.3
Coronary Artery Disease (CAD)	1.7	2.0	6.1	2.5	0.8	0.7	1.6	1.1	1.4	1.2	1.9	1.4	-0.4
Illnesses of mother	1.7	2.1	10.8	0.9	0.8	2.0	0.4	1.4	0.3	1.1	-0.4	0.9	3.3
Hand grip strength (left)	1.6	4.3	18.6	0.5	-4.3	0.3	-2.6	-0.4	-1.5	-1.8	-2.7	-2.1	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.6	13.1	2.9	0.9	1.8	0.9	1.9	0.9	1.8	0.1	1.4	3.6
Illnesses of siblings	1.6	2.3	6.5	-1.3	0.3	0.8	-1.3	-0.7	-2.1	-0.9	-2.2	-1.1	2.6
Mouth/teeth dental problems: Bleeding gums	1.6	2.0	5.9	0.1	-0.6	2.4	-1.2	-1.4	-1.8	-1.7	-1.4	-1.6	0.2
Medication for pain relief, constipation, heartburn	1.6	2.7	10.3	0.3	2.1	1.2	0.9	1.6	1.3	1.8	0.4	1.6	3.2
Medication: Aspirin	1.6	2.1	8.8	3.0	-1.7	-0.7	0.4	1.4	1.2	0.4	1.2	0.5	-1.8
Medication: Aspirin	1.6	2.1	9.5	3.1	-1.5	-0.5	0.6	1.6	1.4	0.6	1.3	0.6	-1.5
Alzheimer’s Disease (including proxy)	1.5	2.2	4.4	-1.8	0.5	1.0	-1.3	-1.5	-2.1	-1.3	-1.8	-1.3	1.7
Type 2 Diabetes (T2D) (2012)	1.5	1.8	3.7	0.9	0.7	-1.3	1.4	1.1	1.9	1.5	1.8	1.5	-0.7
Chronotype (morning person)	1.5	3.4	6.5	-2.4	-1.4	-1.6	-1.3	-2.4	-1.6	-1.6	-1.1	-1.7	-2.6
Hypothyroidism/myxoedema (self-reported)	1.5	3.0	15.0	-2.3	0.9	-1.9	-0.5	-1.9	-0.1	-0.8	0.3	-0.8	-3.9
Mouth/teeth dental problems: Loose teeth	1.5	1.8	2.9	-1.1	-1.3	0.9	-1.2	-1.6	-1.7	-1.5	-1.2	-1.5	-1.0
Basal cell carcinoma (self-reported)	1.5	1.7	3.5	0.5	-1.6	1.9	-1.2	-0.5	-1.6	-1.7	-1.2	-1.5	0.3
Deep venous thrombosis (DVT) (self-reported)	1.5	2.0	4.5	1.8	0.0	-0.4	1.2	2.1	2.1	1.3	1.5	1.2	-0.6
Major Depression (MDD)	1.4	1.7	4.3	-1.3	1.3	0.5	-1.2	0.0	-2.1	-1.7	-1.2	-1.4	-0.9
Fed-up feelings	1.4	2.6	6.7	-2.6	0.8	-1.1	-0.8	-2.4	-1.9	-1.7	-0.7	-1.5	-1.5
High blood pressure	1.4	3.8	9.0	2.6	-1.8	-0.9	1.4	2.1	3.0	1.8	2.0	1.7	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.2	3.7	1.1	1.3	1.4	1.8	0.6	1.9	1.7	1.9	1.8	-0.5
Blood clot in the leg (DVT)	1.4	1.9	3.9	1.8	0.2	-0.3	1.3	1.9	2.0	1.2	1.6	1.2	-0.6
Headache pain in last month	1.4	2.4	4.2	-2.0	-0.7	0.7	-1.2	-2.1	-2.0	-1.9	-1.0	-1.7	-1.2
Bipolar Disorder or Schizophrenia	1.3	3.2	6.4	-1.2	-1.3	1.1	-2.5	-1.6	-2.1	-1.9	-2.5	-2.2	-0.3
Mean Putamen Volume	1.3	1.4	7.1	2.7	-0.6	1.8	0.7	0.9	0.8	0.5	0.9	0.7	-0.3
Hand grip strength (right)	1.3	3.7	17.9	0.8	-4.2	1.4	-2.2	-0.1	-1.3	-1.2	-2.4	-1.4	0.7
Medication: Levothyroxine sodium	1.3	2.2	8.4	-1.7	0.1	-0.8	-1.1	-2.1	-1.0	-1.3	-0.5	-1.3	-2.9
Heart attack	1.3	1.7	12.5	0.2	-1.1	-1.4	-0.6	0.2	0.8	-0.5	0.1	-0.5	-3.5
Noisy workplace	1.3	1.6	10.0	0.8	0.8	3.2	0.8	-0.3	-1.1	-0.0	0.4	0.3	1.6
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	3.2	-0.1	0.8	-1.3	1.4	0.7	1.8	1.4	1.4	1.5	0.1
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	3.7	-1.9	0.0	0.9	-1.3	-1.6	-1.8	-1.1	-1.9	-1.2	1.6
Wears glasses or contact lenses	1.3	1.5	2.8	0.6	0.2	-0.5	1.5	1.4	1.7	1.5	1.6	1.6	0.2
Ever smoked	1.3	2.3	4.3	1.4	1.3	0.1	2.1	1.6	1.1	1.4	1.9	1.7	1.7
Type 2 Diabetes (T2D) (2018)	1.2	2.2	5.7	2.0	-0.2	-0.2	1.1	2.4	1.8	1.5	1.4	1.6	1.0
Had menopause	1.2	1.5	3.4	1.1	-0.8	-0.7	0.8	1.7	1.8	1.4	1.2	1.3	-0.5
Time employed in main current job	1.2	1.4	2.1	1.4	0.1	1.5	0.8	1.1	1.3	1.4	0.5	1.3	1.4
Number of live births	1.2	1.7	5.1	1.0	1.0	0.0	2.2	1.1	0.8	1.2	2.1	1.6	0.5
Forced expiratory volume in 1-second (FEV1)	1.2	4.0	7.6	-0.7	-2.6	-1.6	-2.5	-1.4	-1.9	-2.2	-2.8	-2.4	-0.7
Miserableness	1.2	2.1	8.6	-0.5	2.9	0.5	1.9	-0.0	0.9	1.4	1.7	1.6	0.2
Pain type(s) experienced in last month: Hip pain	1.2	1.5	10.4	-0.2	-1.4	0.2	0.0	-1.2	0.4	-0.4	0.5	-0.4	-3.2
Heart attack/myocardial infarction (self-reported)	1.2	1.6	11.4	0.1	-1.0	-1.3	-0.7	0.1	0.6	-0.7	-0.0	-0.6	-3.4
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	4.5	2.1	0.4	2.1	1.6	1.0	1.0	0.9	1.4	1.3	0.5
Heart disease (mother)	1.1	1.3	6.9	0.3	-0.3	-0.7	-1.0	-1.2	-0.4	-1.3	-0.5	-1.2	-2.6
Hypertension (Self-reported)	1.1	3.0	7.1	2.3	-1.7	-0.8	1.1	1.8	2.7	1.4	1.8	1.4	-1.5
Back pain experienced in last month	1.1	1.6	9.3	0.0	-2.1	-0.7	0.2	-0.4	0.6	-0.2	0.8	-0.1	-3.1
Tinnitus: Yes, now most or all of the time	1.1	1.3	3.4	-0.1	-0.1	0.4	-0.9	-1.9	-1.6	-1.5	-0.8	-1.3	-1.1
Alzheimer’s Disease (in mother)	1.0	1.1	2.9	-1.7	0.8	1.0	-0.7	-1.4	-1.3	-0.7	-1.0	-0.7	0.8
HbA1C	1.0	1.1	2.2	1.0	0.3	-0.3	1.2	1.5	1.1	1.2	1.0	1.3	1.1
Allergy or Eczema	1.0	2.6	5.7	1.2	1.3	0.4	1.8	1.1	2.4	2.0	2.1	2.0	-0.1
Diabetes (father)	1.0	1.2	2.6	-1.1	-1.6	-0.1	-1.3	-0.9	-0.9	-1.3	-1.2	-1.3	-0.6
Severe depression (siblings)	1.0	1.2	3.1	1.8	-0.4	1.3	1.0	1.1	1.0	1.0	1.0	1.2	0.2
Trunk fat mass	1.0	4.2	24.1	-0.2	-4.9	-1.4	-1.5	0.0	0.5	-1.1	-0.9	-1.4	-3.1
Medication: Ramipril	1.0	1.2	1.9	1.3	0.9	0.7	1.3	1.4	0.9	1.0	1.3	1.2	1.0
Peak expiratory flow (PEF)	1.0	2.4	9.7	1.5	-2.3	-3.1	-0.6	0.1	0.2	-1.0	-0.1	-0.9	-2.2
High blood pressure (siblings)	1.0	1.5	7.0	0.8	0.1	-0.5	1.1	-0.2	1.3	0.4	1.8	0.6	-2.6
Medication: Allopurinol	1.0	1.3	7.4	-1.4	-0.9	-2.7	0.4	0.1	0.9	0.2	0.7	0.3	-1.1
Whole body fat mass	1.0	4.1	23.3	0.1	-4.8	-1.3	-1.3	0.1	0.7	-1.0	-0.6	-1.2	-3.3
Leg fat mass (right)	1.0	3.9	19.0	0.5	-4.4	-1.5	-0.7	0.4	1.2	-0.7	0.2	-0.8	-3.8
Risk taking	1.0	1.4	7.2	-0.9	0.7	2.7	-0.4	-1.5	-1.0	-0.9	-0.2	-0.7	-1.1
Myopia	1.0	1.4	10.4	-0.5	3.2	0.0	0.9	0.1	0.4	0.8	0.8	0.8	0.8
Vascular/heart problems diagnosed by doctor	1.0	2.8	6.1	-2.2	1.1	1.3	-1.1	-1.6	-2.5	-1.2	-1.9	-1.3	1.9
Pain experienced in last month	1.0	1.6	8.5	1.2	1.6	-0.1	-0.6	1.1	-0.4	0.2	-1.2	-0.1	2.9
Leg fat mass (left)	1.0	3.8	21.1	0.4	-4.6	-1.3	-0.9	0.3	0.9	-0.9	-0.1	-1.0	-3.5
Crohns Disease (2017)	0.9	2.0	3.8	0.5	0.8	1.7	1.4	1.1	1.3	1.7	1.1	1.8	1.9
Prostate Cancer	0.9	1.2	3.7	1.9	0.1	-1.1	1.0	1.4	0.9	0.8	0.9	0.9	0.8
Lupus	0.9	1.4	4.0	-1.6	-0.2	-0.6	-1.0	-1.7	-0.7	-0.9	-0.8	-1.0	-2.0
Cardiovascular Disease	0.9	3.1	11.2	2.0	-1.9	-1.8	0.8	0.9	2.0	0.6	1.7	0.7	-3.3
Lung FVC	0.9	4.7	19.5	2.9	1.3	4.4	1.0	0.6	-0.6	0.9	0.3	1.1	3.6
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	3.0	-0.6	-0.1	1.3	1.1	-0.0	1.1	1.0	1.2	1.1	-1.7
Angina	0.9	1.1	6.3	0.9	0.1	-0.4	0.8	0.2	1.1	0.2	1.4	0.5	-2.5
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	11.1	2.1	0.5	1.3	0.2	1.3	0.2	1.1	-0.7	0.7	3.3
Waist circumference	0.9	3.2	19.8	1.0	-4.5	-1.3	-0.6	0.7	1.2	-0.4	0.1	-0.5	-2.7
Medication: Simvastatin	0.9	1.2	3.2	1.6	-0.5	0.6	1.4	0.0	0.7	0.4	1.8	0.8	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	5.1	-0.6	-1.8	-1.5	-2.1	-1.1	-1.8	-2.0	-2.2	-2.1	-0.4
Arm fat mass (right)	0.9	3.6	19.6	0.5	-4.4	-1.1	-1.2	0.1	0.6	-1.0	-0.5	-1.2	-3.2
Medication: Paracetamol	0.9	1.5	3.6	-0.4	-0.3	0.8	0.1	-1.9	-1.8	-1.7	0.3	-1.1	-1.6
Leg fat percentage (right)	0.9	3.3	13.8	1.1	-2.4	-1.2	1.1	0.6	2.1	0.4	2.1	0.6	-3.7
Health satisfaction	0.9	1.1	3.3	0.6	-0.6	0.5	1.6	-0.0	0.8	0.7	1.8	1.0	-1.4
Breast cancer (self-reported)	0.9	1.1	1.8	-0.8	-0.7	1.2	-1.2	-0.9	-1.3	-1.2	-1.2	-1.3	-0.3
Illnesses of father: None of the above (group 1)	0.9	1.1	2.0	-0.6	-0.2	1.4	-1.1	-1.2	-1.4	-0.9	-1.4	-0.9	0.8
High cholesterol (Self-reported)	0.9	1.5	5.9	2.4	0.3	0.9	1.2	0.6	1.0	0.6	1.6	1.0	-1.2
Number of operations (self-reported)	0.9	1.4	2.3	1.2	0.9	1.5	1.0	1.0	1.5	1.4	1.2	1.2	0.2
Commuting to job workplace: Cycle	0.9	1.1	8.7	0.8	1.2	3.0	0.0	-0.1	-0.4	-0.1	0.1	-0.1	0.5
Alcohol drinker status: Previous	0.9	1.0	7.6	-0.6	0.2	2.8	-0.2	-0.5	-0.9	-0.4	-0.3	-0.4	0.4
Taking other prescription medications	0.8	1.2	4.0	0.6	0.0	0.2	1.6	-0.1	1.0	0.5	1.9	0.8	-2.0
Age when periods started (menarche)	0.8	1.8	7.6	-2.8	-0.3	-1.4	-1.2	-0.8	-1.4	-1.1	-1.3	-1.3	-0.1
Stomach or abdominal pain in last month	0.8	1.0	2.3	0.7	0.1	0.9	1.2	0.2	1.3	0.8	1.5	1.0	-1.5
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	3.3	-1.8	-0.4	-1.0	-0.9	-1.1	0.1	-0.4	-0.8	-0.5	-1.6
Alcohol intake versus 10 years previously	0.8	1.2	9.3	-1.0	0.4	3.0	0.3	-1.0	0.0	0.0	0.4	-0.0	-0.6
Qualifications: A levels/AS levels or equivalent	0.8	1.7	3.2	1.8	0.7	-1.2	1.3	1.6	1.1	1.3	1.1	1.5	1.3
Ever highly irritable/argumentative for 2 days	0.8	1.0	6.4	0.4	2.5	1.3	0.4	0.6	-0.1	0.3	0.4	0.3	0.9
Loud music exposure frequency	0.8	0.9	2.7	1.1	0.2	-0.2	0.0	1.6	1.3	1.2	-0.0	0.7	1.1
Angina (self-reported)	0.8	1.1	7.2	0.7	-0.0	-0.5	0.6	0.1	1.0	0.2	1.3	0.4	-2.7
Medication: Seretide 50 evohaler	0.8	0.9	2.1	-1.4	-0.0	1.0	-0.8	-1.4	-1.1	-0.9	-0.8	-0.8	-0.5
Number of full sisters	0.8	1.0	3.2	-1.8	1.5	0.8	0.6	-1.1	-1.2	-0.6	0.6	-0.2	-0.2
Family relationship satisfaction	0.8	0.9	2.5	0.2	-1.2	1.6	-0.4	-1.2	-0.6	-1.0	-0.1	-0.7	-1.4
Commuting to job workplace: Walk	0.8	0.9	1.6	-0.4	0.9	0.4	1.3	-0.2	1.2	1.0	1.2	1.3	-0.7
Arm fat mass (left)	0.8	3.5	19.3	0.5	-4.4	-1.0	-1.1	0.1	0.6	-1.0	-0.4	-1.1	-3.2
Illnesses of father: High blood pressure	0.8	1.0	2.9	0.8	0.8	-1.2	0.5	0.9	1.7	1.2	0.8	1.0	-0.9
Alcohol drinker status: Never	0.8	0.9	2.5	-0.6	1.6	0.7	0.8	1.0	0.5	1.0	0.9	1.0	1.2
Depression (Nagel 2018)	0.7	1.0	2.7	-1.2	0.9	1.6	0.6	-1.5	-0.2	-0.1	0.7	0.0	-1.4
Reaction Time	0.7	1.4	5.8	-1.6	-1.7	-2.4	-0.8	-0.2	-0.5	-0.6	-0.6	-0.7	-0.7
Verbal and Numeric Reasoning (VNR)	0.7	1.7	6.4	-1.0	-1.0	-2.1	-1.0	-1.3	0.8	-0.4	-0.4	-0.7	-2.5
Breast Cancer	0.7	1.7	6.5	2.5	1.1	1.0	0.9	1.0	1.6	1.1	1.3	1.1	0.3
HDL Cholesterol	0.7	1.2	4.3	0.9	-0.1	2.1	-0.9	-0.0	-1.3	-0.9	-1.1	-0.9	1.3
Tanning	0.7	9.1	17.5	-4.2	-1.5	-2.2	-3.6	-3.2	-2.5	-2.8	-3.5	-3.2	-2.5
Diabetes (mother)	0.7	0.9	3.2	-0.1	-0.8	-1.8	0.6	0.3	1.0	0.4	1.0	0.5	-1.5
Townsend deprivation index at recruitment	0.7	1.0	3.3	-1.8	0.7	0.9	-0.8	-0.6	-1.4	-0.9	-1.0	-0.9	0.2
Serious illness, injury or assault to yourself	0.7	0.9	3.9	-0.4	-1.4	1.2	-0.6	-0.6	0.4	-0.5	-0.3	-0.5	-2.0
Chronic bronchitis/emphysema (father)	0.7	0.8	5.6	-1.0	-0.4	-2.4	-0.1	-0.1	-0.7	-0.6	-0.2	-0.4	-0.0
Mouth/teeth dental problems	0.7	1.1	5.7	0.5	-1.0	-2.4	-0.6	1.4	0.3	0.1	-0.7	-0.1	1.0
Medication: Lansoprazole	0.7	0.8	4.7	0.9	-2.2	0.6	0.3	0.1	0.9	0.4	0.4	0.4	-1.0
Shortness of breath walking on level ground	0.7	0.8	1.4	0.1	-0.7	0.6	-0.8	-1.1	-1.2	-1.2	-0.5	-1.1	-1.2
Mean time to correctly identify matches	0.7	1.4	5.3	0.3	-2.2	-2.3	-0.1	1.5	0.8	0.4	0.2	0.3	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	3.7	-1.0	0.2	-1.9	-1.0	-0.6	-0.4	-0.6	-0.7	-0.8	-0.5
Medication for cholesterol	0.7	1.0	4.0	-1.8	2.0	0.2	0.1	-1.0	-0.9	-0.1	-0.4	-0.2	1.1
Osteoarthritis (self-reported)	0.7	0.9	2.1	-0.7	-1.4	0.2	-1.2	-0.8	-0.6	-0.6	-1.4	-0.8	-0.7
Medication: Bendroflumethiazide	0.7	1.0	1.9	0.8	0.5	-0.1	1.0	1.4	1.1	1.0	1.1	1.1	1.3
Leg fat percentage (left)	0.7	2.7	9.3	1.2	-2.8	-0.7	0.9	0.6	1.7	0.2	1.8	0.4	-3.1
Average weekly beer plus cider intake	0.7	1.0	1.8	-0.5	1.2	-0.2	1.3	0.5	1.0	1.3	1.2	1.3	0.4
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.3	1.0	1.1	-0.8	0.8	1.0	1.1	1.0	0.8	0.9	0.4
Blood Eosinophil Count	0.6	5.0	14.7	-2.4	0.0	-1.7	-1.9	-2.9	-1.6	-2.2	-1.4	-2.2	-3.8
Systolic Blood Pressure	0.6	2.8	9.7	-1.4	-2.2	-3.1	-1.4	-1.1	-0.1	-1.0	-0.9	-1.2	-2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	3.5	-1.1	0.1	0.6	0.0	-1.5	-0.5	-0.6	-0.0	-0.5	-1.9
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.4	-0.6	-0.2	1.5	-0.7	-1.0	-0.5	-0.6	-0.4	-0.7	-1.0
Qualifications: CSEs or equivalent	0.6	0.8	2.0	-0.4	-0.5	1.3	-1.2	-0.2	-0.8	-0.8	-1.4	-0.9	0.6
Body mass index (BMI)	0.6	2.4	10.4	1.1	-3.2	-0.6	-0.2	0.2	0.9	-0.5	0.7	-0.5	-3.2
Alcohol usually taken with meals	0.6	1.0	4.1	0.6	1.0	0.5	0.8	1.2	0.5	0.9	0.4	0.9	2.0
Pain all over the body in last month	0.6	0.7	3.5	-0.8	1.0	-0.8	-0.1	-0.9	-0.3	-0.4	0.1	-0.3	-1.9
Glaucoma (self-reported)	0.6	0.7	2.3	-0.4	-0.3	-1.5	1.4	-0.4	-0.0	0.2	1.5	0.6	-0.4
Gout (self-reported)	0.6	0.8	4.3	-1.3	-1.0	-2.1	-0.1	-0.1	0.3	-0.1	0.1	-0.1	-0.8
Medication: Amlodipine	0.6	0.8	3.3	-0.5	-1.4	-1.8	-0.1	-0.2	0.5	0.2	0.4	0.1	-1.4
Body fat percentage	0.6	2.4	8.3	0.7	-2.6	-1.1	0.7	0.7	1.9	0.3	1.5	0.4	-2.9
Number of full brothers	0.6	0.8	5.9	-0.7	0.1	2.4	0.6	-0.5	-0.6	-0.3	0.4	0.0	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.7	1.2	0.7	-1.1	0.1	1.3	0.9	0.9	0.1	0.6	0.6
Friendships satisfaction	0.6	0.8	3.1	-0.1	1.7	1.8	0.6	-0.6	-0.4	-0.1	0.7	0.1	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	3.0	0.1	-1.6	-1.2	-0.4	-0.2	0.2	-0.2	0.0	-0.3	-1.7
Ever taken oral contraceptive pill	0.6	0.7	1.5	-1.0	-0.2	-0.7	-0.7	-0.7	-1.2	-1.0	-0.9	-0.9	0.2
Medication: Paracetamol	0.6	0.9	2.2	-0.5	-0.1	1.0	0.1	-1.5	-1.4	-1.3	0.1	-0.8	-1.1
Diastolic blood pressure, automated reading	0.6	1.8	8.7	-0.5	-2.3	-0.7	-1.0	-0.2	1.0	-0.3	-0.4	-0.6	-3.0
Ever depressed for a whole week	0.6	0.7	3.1	-0.3	1.8	1.4	0.6	-0.8	-0.6	-0.3	0.7	-0.0	-0.3
Intelligence (Savage-Jansen 2018)	0.5	1.6	6.0	1.0	-0.5	-0.6	0.5	0.5	2.5	1.1	1.4	0.9	-2.0
Alzheimer’s Disease (in father)	0.5	0.6	2.1	-0.1	0.3	0.5	0.6	0.7	0.6	1.0	0.2	0.9	1.5
Ovarian Cancer	0.5	0.7	2.6	1.3	-1.1	1.6	-0.3	-0.7	-0.5	-0.2	-0.2	-0.2	0.2
Body Mass Index (BMI) (2010)	0.5	0.7	4.2	0.2	-2.0	-1.0	-0.6	-0.6	-0.2	-0.5	-0.5	-0.6	-0.7
Rheumatoid Arthritis	0.5	0.6	1.4	-1.0	1.0	0.0	-0.6	-1.2	-0.6	-0.7	-0.4	-0.8	-0.9
Sensitivity / hurt feelings	0.5	0.8	4.1	0.3	0.5	2.0	0.0	-0.9	-1.1	-0.6	-0.3	-0.4	0.8
Systolic blood pressure, automated reading	0.5	1.5	5.2	-0.1	-2.3	-1.9	-0.3	0.6	1.6	0.6	0.1	0.3	-1.6
Vitamin and mineral supplements	0.5	0.7	3.9	-2.0	1.1	-1.3	0.1	-0.4	0.2	0.3	0.0	0.3	-0.3
Trunk fat percentage	0.5	2.0	8.5	0.2	-2.9	-1.1	0.1	0.4	1.4	-0.0	0.8	-0.0	-2.7
Financial difficulties in last 2 years	0.5	0.7	2.7	-0.6	-0.6	1.6	-0.2	-0.9	-1.0	-0.9	-0.3	-0.7	-0.8
Fluid intelligence score	0.5	1.0	3.9	0.1	-0.7	-1.6	-0.0	-0.7	1.5	0.5	0.5	0.3	-2.0
Impedance of arm (right)	0.5	2.2	10.8	-0.9	3.3	-0.5	1.1	0.7	0.7	1.3	0.8	1.3	2.1
Arm fat percentage (right)	0.5	1.8	5.3	1.4	-1.7	-0.6	0.9	0.9	1.7	0.4	1.7	0.5	-2.3
Worrier / anxious feelings	0.5	0.9	2.6	1.6	0.4	0.2	1.1	0.4	1.0	1.2	1.1	1.2	0.2
Pulse rate	0.5	0.8	2.1	-0.9	0.0	-0.8	-0.6	-0.8	-0.8	-1.1	-0.5	-1.0	-1.4
Asthma	0.5	0.9	3.5	-1.0	1.5	1.9	0.3	-1.2	-0.9	-0.5	0.2	-0.2	-0.3
Depression (self-reported)	0.5	0.7	2.4	1.2	-1.6	0.5	0.7	-0.2	-0.1	-0.4	0.8	0.1	-1.1
Medication: Ventolin 100micrograms inhaler	0.5	0.6	2.5	1.0	0.2	1.6	0.8	0.5	-0.2	0.0	0.7	0.4	0.9
Wheeze or whistling in the chest in last year	0.5	0.9	5.4	0.6	0.1	2.3	-0.3	-0.2	-0.5	-0.7	0.3	-0.6	-1.3
Overall health rating	0.5	1.0	3.4	0.0	-0.3	0.6	1.6	0.3	0.8	0.8	1.8	1.1	-0.9
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.3	0.3	-0.7	-1.1	-0.9	-0.6	-0.8	-0.9	-0.8	-1.0	-0.2
Knee pain experienced in last month	0.5	0.7	2.5	-0.6	-1.0	0.4	0.8	-0.2	0.8	0.4	1.2	0.6	-1.6
Arm fat percentage (left)	0.5	2.0	7.1	1.1	-1.9	-1.0	0.9	0.8	1.6	0.3	1.6	0.4	-2.7
Mineral and other dietary supplements	0.5	0.6	3.8	-1.9	0.5	-0.6	-0.1	-1.1	-0.5	-0.2	-0.2	-0.2	-0.2
Asthma (self-reported)	0.5	0.9	3.6	-0.8	1.6	1.9	0.6	-1.0	-0.6	-0.2	0.6	0.0	-0.3
Guilty feelings	0.5	0.7	2.4	-0.5	1.6	0.2	1.2	-0.3	0.2	0.7	1.0	0.9	-0.0
Commuting to job workplace: Public transport	0.5	0.6	1.1	-1.1	0.1	-0.5	1.0	0.6	0.7	0.9	0.8	0.9	0.4
Eye problems/disorders: Glaucoma	0.5	0.6	2.3	-0.8	-1.5	-1.2	0.2	-1.0	-0.7	-0.4	0.2	-0.2	-0.1
Medication: Blood pressure	0.5	1.0	2.9	1.5	-1.7	-0.9	0.2	1.2	1.2	0.6	0.5	0.6	-0.2
Impedance of whole body	0.5	2.4	9.3	-0.9	3.1	-0.3	1.6	0.3	1.1	1.7	1.4	1.8	1.2
Neuroticism (Nagel 2018)	0.4	1.0	2.3	0.1	1.5	0.8	1.5	-0.3	0.5	0.9	1.5	1.3	0.0
Schizophrenia (2018)	0.4	0.8	5.7	0.9	-0.2	2.4	-0.2	0.6	0.1	0.4	-0.3	0.3	1.1
Neuroticism (2016)	0.4	0.6	1.7	0.4	1.3	1.2	0.9	-0.6	-0.2	0.3	0.8	0.1	0.8
Primary Biliary Cirrhosis	0.4	0.6	1.6	-1.2	-0.0	-0.5	-0.3	-1.2	-1.3	-0.8	-0.5	-0.7	0.1
Schizophrenia (2014)	0.4	1.0	3.6	1.1	-0.4	1.9	0.5	1.1	0.6	0.7	0.5	0.8	1.1
Blood Red Count	0.4	4.2	14.6	1.1	0.0	-0.8	1.6	1.0	3.1	1.4	2.8	1.4	-3.8
BMI	0.4	2.5	11.3	1.6	-2.4	-1.0	0.0	0.8	1.6	-0.1	1.1	-0.2	-3.4
Respiratory disease	0.4	1.0	3.4	-1.3	1.8	0.9	0.6	-1.4	-0.9	-0.4	0.6	0.0	-0.3
Number of treatments/medications taken	0.4	0.7	3.8	0.9	-0.8	-0.1	0.5	0.5	0.6	0.0	1.0	0.2	-1.9
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.8	-1.4	0.4	0.7	-0.2	-1.2	-0.3	-0.3	0.0	-0.3	-1.2
Medication: Co-codamol	0.4	0.5	1.1	-0.3	-1.0	0.5	-0.8	-0.2	-0.4	-0.7	-0.8	-0.9	-0.8
Current tobacco smoking	0.4	0.7	1.7	-0.7	-0.3	1.2	-0.5	-1.0	-1.3	-1.1	-0.4	-0.8	-0.3
Multivitamins +/- minerals	0.4	0.5	2.3	1.5	-0.9	0.6	0.3	0.5	0.7	0.3	0.5	0.3	-0.6
Past tobacco smoking	0.4	0.8	2.1	-0.9	-0.6	-0.9	-1.5	-0.5	-0.1	-0.3	-1.3	-0.7	-1.0
Father’s age at death	0.4	0.6	1.1	-0.8	-0.8	-0.1	-0.8	-0.8	-1.1	-0.8	-0.9	-0.8	0.2
Impedance of arm (left)	0.4	1.7	8.0	-1.5	2.8	-1.1	0.9	0.1	0.2	0.9	0.5	1.0	1.5
Length of working week for main job	0.4	0.5	3.0	-0.5	0.6	1.7	0.2	0.1	0.5	0.6	0.0	0.4	0.6
Exposure to tobacco smoke at home	0.4	0.4	2.4	-1.6	0.6	-0.4	0.1	0.1	0.6	0.6	-0.2	0.3	0.3
Birth weight of first child	0.4	0.8	2.2	1.4	-1.0	0.2	-0.2	0.5	-1.1	-0.5	-0.8	-0.4	1.5
Exposure to tobacco smoke outside home	0.4	0.5	2.8	-1.7	-0.2	0.4	-0.6	-1.0	-0.0	-0.2	-0.4	-0.5	-0.6
Number of children fathered	0.4	0.4	2.5	-1.0	0.6	-1.6	0.1	-0.2	0.2	0.0	0.3	-0.1	-0.5
Pulse wave peak to peak time	0.4	0.5	1.4	-1.2	-0.2	-0.9	-0.7	-0.5	-0.4	-0.6	-0.6	-0.7	-0.8
Eye problems/disorders: None of the above	0.4	0.5	2.9	-0.0	1.7	1.1	-0.2	0.1	-0.2	-0.2	-0.2	-0.3	0.4
Neck or shoulder pain in last month	0.4	0.6	2.3	0.2	-1.4	0.0	-0.2	-0.3	-0.3	-0.8	0.3	-0.6	-1.5
Migraine (self-reported)	0.4	0.5	3.3	-0.3	0.4	-0.6	-0.3	0.3	-0.7	-0.2	-0.7	-0.3	1.8
Age at last live birth	0.4	0.6	1.4	1.2	1.1	0.8	0.7	0.7	-0.0	0.3	0.5	0.4	1.1
Leg pain on walking	0.4	0.5	3.0	0.4	-1.7	0.9	0.0	0.4	-0.2	-0.4	0.2	-0.3	-0.5
Average weekly red wine intake	0.4	0.6	3.1	0.3	1.8	0.5	-0.7	-0.1	-0.5	-0.4	-0.8	-0.5	0.6
Long-standing illness, disability or infirmity	0.4	0.6	1.0	0.8	-0.3	0.9	0.7	0.1	1.0	0.7	0.8	0.7	-1.0
Mother’s age at death	0.4	0.6	1.7	1.3	0.0	-0.7	0.9	0.7	0.5	0.5	0.9	0.8	0.2
Financial situation satisfaction	0.4	0.5	1.7	-0.1	-1.3	0.7	-0.3	-0.6	-1.0	-0.8	-0.3	-0.6	-0.3
Supplements: Fish oil (including cod liver oil)	0.4	0.5	2.7	1.6	-1.0	-0.9	-0.4	0.6	0.1	-0.2	-0.3	-0.3	-0.2
Medication: Atorvastatin	0.4	0.5	1.7	1.2	-0.6	-0.3	-0.5	1.3	1.0	0.4	-0.1	0.2	-0.3
Irritability	0.4	0.7	4.6	-0.6	-0.7	-0.7	-0.2	-0.7	0.4	-0.1	0.2	-0.1	-2.1
Depressed Affect (Nagel 2018)	0.3	0.7	2.2	-0.7	1.5	0.4	1.1	-0.6	0.3	0.5	1.2	0.6	-0.5
Crohns Disease (2012)	0.3	0.4	2.2	-0.2	0.0	1.3	0.1	0.1	-0.0	0.3	-0.2	0.3	1.5
Waist Hip Ratio (WHR)	0.3	1.3	6.2	2.5	-0.3	-0.4	0.3	1.7	1.4	0.8	0.3	0.8	0.4
Smoking Status	0.3	0.8	4.3	-0.1	0.4	2.1	0.4	-0.8	-1.3	-0.7	0.3	-0.4	0.4
Relative age of first facial hair	0.3	0.7	1.8	1.4	0.4	1.2	0.7	0.8	0.6	0.7	0.6	0.8	0.7
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.0	1.0	0.2	0.5	0.4	0.5	0.6	1.0	0.3	0.8	0.7
Ever had hysterectomy (womb removed)	0.3	0.3	1.0	0.1	-0.2	1.0	0.1	0.1	0.9	0.7	0.5	0.5	-0.8
Medication for hormone replacement therapy	0.3	0.3	1.2	0.8	-0.8	1.1	-0.3	0.6	-0.2	-0.1	-0.4	-0.1	0.4
Impedance of leg (right)	0.3	1.5	3.9	-0.8	2.0	-0.2	1.5	-0.3	1.3	1.4	1.5	1.5	-0.4
Average weekly fortified wine intake	0.3	0.4	1.4	0.3	-0.5	-0.2	-0.8	0.6	-0.2	-0.0	-1.0	-0.3	1.2
Supplements: Glucosamine	0.3	0.4	1.5	0.8	-1.2	-0.4	-0.6	0.6	0.2	-0.1	-0.6	-0.2	0.4
Medication: Atenolol	0.3	0.3	0.9	1.0	-0.9	-0.8	-0.4	0.4	0.7	0.2	-0.1	0.0	-0.6
Impedance of leg (left)	0.3	1.6	3.9	-0.5	2.0	0.6	1.6	-0.0	1.1	1.6	1.4	1.6	0.8
Nervous feelings	0.3	0.6	2.0	1.4	-0.6	0.4	0.8	0.5	0.5	0.7	0.6	0.9	0.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	2.3	-0.3	1.5	-0.9	0.1	-0.3	-0.2	-0.2	0.4	-0.2	-0.8
Qualifications: None of the above	0.3	0.6	2.1	-0.8	0.4	0.3	-0.2	-1.0	-1.4	-1.0	-0.3	-0.8	0.7
Falls in the last year	0.3	0.4	2.6	0.4	-0.2	1.6	-0.4	-0.0	-0.4	-0.1	-0.6	-0.3	0.6
Happiness	0.3	0.4	2.4	0.1	0.1	1.5	0.2	-0.7	-0.7	-0.3	0.3	-0.1	-0.3
Medication: Cholesterol lowering	0.3	0.5	4.2	0.7	0.4	-0.3	-0.1	0.1	0.2	-0.4	0.4	-0.2	-2.1
Comparative body size at age 10	0.3	0.8	2.7	1.5	-1.7	0.5	0.0	-0.2	0.5	-0.1	0.5	0.0	-1.5
Medication: Omeprazole	0.3	0.4	1.1	0.7	-0.2	0.3	1.0	0.8	0.3	0.4	1.0	0.5	-0.1
Supplements: Vitamin C	0.3	0.3	1.2	1.1	-0.9	-0.0	-0.5	0.5	-0.2	-0.4	-0.2	-0.4	0.1
Illnesses of siblings: Diabetes	0.3	0.4	1.2	0.8	-1.1	0.5	-0.3	0.7	0.3	0.3	-0.3	0.1	0.7
Mood swings	0.3	0.6	2.0	-0.7	1.4	0.7	0.8	-0.6	0.1	0.2	1.0	0.4	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.1	0.7	0.4	1.0	0.6	-0.2	-0.4	-0.1	0.5	0.1	0.5
Smoking status: Current	0.3	0.5	1.9	-0.3	-0.5	1.4	-0.4	-0.5	-0.9	-0.7	-0.4	-0.6	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	3.3	1.8	-0.0	0.3	0.8	0.9	0.5	0.4	0.9	0.7	0.6
Hearing aid user	0.3	0.3	1.1	-0.4	0.6	0.3	0.4	0.5	0.6	0.5	0.2	0.5	1.0
LDL Cholesterol	0.2	0.3	0.8	0.3	0.3	0.6	0.7	-0.3	0.2	0.0	0.8	0.3	-0.9
Ulcerative Colitis	0.2	0.3	1.0	0.6	-0.3	-0.6	-0.3	1.0	0.9	0.2	0.1	0.2	0.0
Neuroticism	0.2	0.5	1.6	0.2	1.3	0.9	0.7	-0.1	0.1	0.6	0.5	0.6	1.0
Hair Pigment	0.2	6.1	14.6	-0.9	-1.3	3.0	-2.0	-3.0	-3.8	-2.9	-2.4	-2.8	0.8
Relative age voice broke	0.2	0.3	1.0	0.9	0.1	0.7	0.5	0.3	-0.0	0.5	0.2	0.5	1.0
Had other major operations	0.2	0.2	0.7	0.5	0.2	0.8	0.1	0.3	0.7	0.5	0.3	0.4	-0.3
Neuroticism score	0.2	0.4	1.4	0.1	1.2	0.8	0.6	-0.4	-0.2	0.3	0.4	0.5	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.9	0.0	0.8	0.7	0.6	-0.4	-0.5	-0.6	0.7	-0.1	-1.0
Hair/balding pattern: Pattern 3	0.2	0.2	0.6	0.7	-0.4	0.0	-0.8	0.3	-0.1	-0.3	-0.4	-0.5	-0.6
Mouth/teeth dental problems: Dentures	0.2	0.3	0.7	-0.8	-0.3	0.7	0.3	-0.1	0.6	0.7	0.5	0.5	-0.7
Lung cancer (father)	0.2	0.2	0.8	-0.2	-0.7	0.9	0.5	-0.5	0.0	0.2	0.4	0.3	-0.0
Pulse wave Arterial Stiffness index	0.2	0.2	0.9	0.8	-0.4	1.0	0.1	0.2	0.1	0.3	-0.0	0.2	0.7
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.7	0.6	-0.6	0.8	0.0	0.5	0.9	0.3	0.3	0.3	-0.4
Worry too long after embarrassment	0.2	0.4	1.5	-0.3	0.4	0.6	0.4	-1.2	-0.8	0.0	0.1	0.3	0.8
Pulse rate, automated reading	0.2	0.7	1.6	0.2	-0.2	1.3	-1.1	-0.2	-0.7	-1.0	-1.1	-1.1	0.0
Had major operations	0.2	0.2	0.8	0.2	0.0	-0.0	-0.1	0.6	0.8	0.9	-0.3	0.5	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	1.0	-1.0	-0.4	0.8	-0.1	0.0	0.1	0.3	-0.1	0.1	-0.6
Smoking status: Previous	0.2	0.3	1.1	0.7	0.2	0.4	1.1	-0.0	-0.4	-0.2	0.9	0.2	0.3
Loneliness, isolation	0.2	0.3	1.5	-0.4	1.2	0.8	0.4	-0.3	0.3	0.4	0.5	0.4	-0.2
Fractured/broken bones in last 5 years	0.2	0.2	1.5	-0.6	0.5	0.1	-0.1	0.1	0.5	-0.1	0.3	-0.0	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	1.4	0.9	-1.2	0.3	0.3	0.7	0.2	0.1	0.3	0.2	0.1
Worry (Nagel 2018)	0.1	0.3	1.0	1.0	-0.8	1.0	-0.1	-0.1	0.1	0.1	-0.1	0.1	0.2
Triglycerides	0.1	0.1	0.3	0.1	-0.4	-0.2	-0.3	-0.6	-0.3	-0.3	-0.3	-0.3	-0.2
Average weekly spirits intake	0.1	0.2	0.9	0.0	0.1	0.7	-0.2	0.3	-0.2	0.3	-0.4	0.1	0.9
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	0.2	-0.2	0.3	-0.5	-0.1	-0.3	-0.4	-0.4	-0.5	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.8	-0.0	-0.1	-0.1	0.3	0.3	0.9	0.7	0.5	0.6	-0.5
Hair/balding pattern: Pattern 2	0.1	0.1	0.7	0.8	0.1	-0.1	0.3	-0.1	0.0	0.2	0.1	0.2	0.7
Tense / ‘highly strung’	0.1	0.1	0.4	0.5	0.1	0.6	0.1	-0.4	0.2	0.2	0.1	0.2	-0.5
Pulse wave reflection index	0.1	0.1	0.4	0.1	-0.4	0.3	0.1	0.2	-0.1	0.2	0.1	0.1	0.7
Emphysema/chronic bronchitis	0.1	0.1	0.5	-0.2	-0.7	0.4	0.0	0.2	0.0	0.1	0.1	0.0	0.2
Suffer from ‘nerves’	0.1	0.2	0.4	0.7	0.0	0.2	0.5	-0.6	-0.2	0.2	0.4	0.4	0.6
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.7	0.1	-0.5	-0.8	-0.1	0.3	-0.1	0.2	-0.2	0.2	0.7
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.4	-0.2	0.7	-0.4	0.3	0.2	-0.1	0.1	0.3	0.3	0.6
Hair/balding pattern: Pattern 4	0.0	0.1	0.4	0.1	0.2	-0.6	0.1	-0.2	-0.5	-0.3	-0.1	-0.2	-0.5

Hub : Genes

ABHD15

Models

Trait associations