Best TWAS P=5.31e-11 · Best GWAS P=9.17e-12 conditioned to 0.0314
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | RP11-373D23.3 | 0.23 | 0.12 | enet | 12 | 0.06 | 2.5e-04 | -6.3 | 6.6 | 5.3e-11 | -0.74 | 0.04 | 0.94 | TRUE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | RP11-373D23.3 | 0.17 | 0.01 | enet | 15 | 0.04 | 1.2e-02 | -6.8 | 5.5 | 2.9e-08 | -0.60 | 0.02 | 0.78 | FALSE |
| 3 | GTEx | Lung | RP11-373D23.3 | 0.08 | 0.00 | enet | 21 | 0.02 | 2.3e-02 | -1.5 | 6.0 | 1.8e-09 | -0.47 | 0.07 | 0.70 | FALSE |
| 4 | GTEx | Testis | AC074117.10 | 0.14 | 0.08 | lasso | 6 | 0.12 | 4.5e-06 | -4.4 | 5.3 | 1.4e-07 | -0.10 | 0.04 | 0.96 | TRUE |
| 5 | GTEx | Thyroid | RP11-373D23.3 | 0.16 | 0.07 | enet | 19 | 0.04 | 2.6e-04 | -6.3 | 5.7 | 1.1e-08 | -0.62 | 0.08 | 0.87 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FNDC4 | 0.13 | 0.06 | lasso | 2 | 0.05 | 1.1e-03 | 5.3 | -5.2 | 1.8e-07 | 0.05 | 0.00 | 0.93 | FALSE |