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chr2:101,981,794-103,767,612

Best TWAS P=2.34e-12 · Best GWAS P=1.43e-11 conditioned to 0.00978

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	IL18R1	0.31	0.38	bslmm	580	0.38	5.4e-49	-6.7	6.2	4.2e-10	-0.95	0.02	0.98	FALSE
2	CommonMind	Brain Pre-frontal Cortex	IL1R1	0.14	0.09	lasso	3	0.10	4.0e-12	5.4	-5.7	1.4e-08	0.20	0.94	0.06	FALSE
3	GTEx	Brain Caudate basal ganglia	IL18R1	0.17	0.23	lasso	6	0.20	1.6e-06	-6.6	6.7	2.7e-11	-0.99	0.01	0.98	FALSE
4	GTEx	Brain Cerebellar Hemisphere	IL18R1	0.25	0.25	enet	9	0.10	1.8e-03	-5.8	6.3	4.0e-10	-0.92	0.03	0.94	FALSE
5	GTEx	Brain Cerebellum	IL18R1	0.25	0.30	enet	26	0.26	3.4e-08	-6.6	6.2	5.3e-10	-0.93	0.01	0.98	FALSE
6	GTEx	Brain Cortex	IL18R1	0.21	0.12	lasso	9	0.13	1.7e-04	-6.7	6.6	5.2e-11	-0.96	0.02	0.97	FALSE
7	GTEx	Brain Hippocampus	IL18R1	0.25	0.06	lasso	11	0.07	1.0e-02	1.9	5.7	1.5e-08	-0.69	0.04	0.82	FALSE
8	GTEx	Brain Putamen basal ganglia	IL1RL1	0.24	0.12	lasso	8	0.21	8.7e-06	-6.6	5.5	3.2e-08	-0.79	0.03	0.77	FALSE
9	GTEx	Brain Putamen basal ganglia	IL18R1	0.30	0.22	enet	21	0.24	1.8e-06	-6.7	6.4	1.6e-10	-0.91	0.02	0.98	FALSE
10	GTEx	Heart Atrial Appendage	IL1R1	0.13	0.04	enet	26	0.06	9.8e-04	4.2	7.0	2.3e-12	-0.70	0.04	0.83	TRUE
11	GTEx	Lung	IL1RL1	0.31	0.20	lasso	6	0.20	2.3e-15	-6.6	5.6	1.8e-08	-0.96	0.02	0.98	FALSE
12	GTEx	Lung	IL18R1	0.06	0.01	lasso	4	0.02	1.2e-02	-6.7	5.5	3.2e-08	-0.93	0.02	0.95	FALSE
13	GTEx	Skin Sun Exposed Lower leg	IL18R1	0.05	0.02	lasso	6	0.02	7.4e-03	6.3	6.5	8.8e-11	-0.52	0.12	0.76	FALSE
14	GTEx	Whole Blood	IL18RAP	0.14	0.18	lasso	10	0.18	6.0e-16	5.9	-5.5	2.9e-08	0.48	0.14	0.86	FALSE
15	NTR	Blood	IL1RL1	0.04	0.04	lasso	6	0.04	7.7e-13	6.4	-6.4	1.8e-10	0.55	0.07	0.93	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	IL1RL1	0.45	0.51	enet	20	0.51	4.8e-77	-6.7	6.6	4.8e-11	-0.98	0.01	0.99	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	IL18R1	0.42	0.52	lasso	5	0.52	6.2e-78	-6.7	6.7	2.2e-11	-0.99	0.01	0.99	FALSE
18	The Cancer Genome Atlas	Brain Lower Grade Glioma	IL18R1	0.25	0.29	blup	108	0.31	1.6e-35	-6.7	6.0	2.4e-09	-0.93	0.01	0.99	FALSE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	IL18RAP	0.03	0.03	lasso	3	0.01	7.7e-03	6.3	-5.2	2.5e-07	0.35	0.01	0.90	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	IL1RL1	0.13	0.20	enet	8	0.20	4.5e-22	-6.7	6.7	2.3e-11	-0.99	0.01	0.99	FALSE