[Hub]/) : Traits : Irritable Bowel Disease (IBD) : ← →

chr2:218,296,003-219,878,756

Best TWAS P=4.76e-10 · Best GWAS P=1.21e-09 conditioned to 0.0326

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	PNKD	0.12	0.08	lasso	3	0.07	4.2e-06	5.2	-5.3	1.0e-07	0.69	0.50	0.49	FALSE
2	GTEx	Adipose Subcutaneous	TMBIM1	0.12	0.08	lasso	5	0.10	2.9e-08	5.2	-5.2	2.2e-07	0.68	0.60	0.40	FALSE
3	GTEx	Adipose Subcutaneous	RP11-378A13.1	0.25	0.34	lasso	9	0.37	2.4e-31	5.1	-5.2	1.7e-07	0.70	0.60	0.40	FALSE
4	GTEx	Adipose Visceral Omentum	TMBIM1	0.17	0.03	enet	31	0.03	1.1e-02	5.0	-5.6	1.8e-08	0.67	0.10	0.80	FALSE
5	GTEx	Adipose Visceral Omentum	RP11-378A13.1	0.30	0.28	enet	30	0.32	2.9e-17	5.0	-5.5	4.3e-08	0.80	0.38	0.62	FALSE
6	GTEx	Adrenal Gland	PNKD	0.20	0.16	lasso	5	0.19	1.6e-07	5.0	-5.5	4.2e-08	0.70	0.07	0.91	FALSE
7	GTEx	Adrenal Gland	RP11-378A13.1	0.25	0.22	enet	17	0.30	3.2e-11	5.2	-5.3	1.4e-07	0.70	0.60	0.40	FALSE
8	GTEx	Artery Aorta	TMBIM1	0.17	0.20	enet	29	0.19	1.2e-10	5.2	-5.9	3.0e-09	0.71	0.59	0.41	FALSE
9	GTEx	Artery Aorta	RP11-378A13.1	0.28	0.28	enet	20	0.31	2.2e-17	4.7	-5.1	2.8e-07	0.73	0.76	0.24	FALSE
10	GTEx	Artery Coronary	TMBIM1	0.22	0.08	lasso	1	0.03	3.6e-02	5.2	-5.2	1.8e-07	0.65	0.14	0.15	FALSE
11	GTEx	Artery Coronary	RP11-378A13.1	0.34	0.36	lasso	8	0.38	1.2e-13	5.2	-5.4	8.3e-08	0.69	0.60	0.40	FALSE
12	GTEx	Artery Tibial	RP11-378A13.1	0.20	0.17	enet	13	0.24	7.6e-19	4.6	-5.2	2.6e-07	0.70	0.64	0.36	FALSE
13	GTEx	Brain Caudate basal ganglia	RP11-378A13.1	0.55	0.38	enet	17	0.52	4.0e-17	5.0	-5.3	1.0e-07	0.68	0.69	0.31	FALSE
14	GTEx	Brain Cerebellar Hemisphere	RP11-378A13.1	0.53	0.57	enet	24	0.60	3.3e-19	5.0	-5.4	6.9e-08	0.74	0.68	0.32	FALSE
15	GTEx	Brain Cerebellum	RP11-378A13.1	0.46	0.52	enet	15	0.46	2.5e-15	4.7	-5.1	2.7e-07	0.72	0.72	0.28	FALSE
16	GTEx	Brain Cortex	PNKD	0.18	0.12	enet	7	0.11	6.8e-04	5.0	5.3	1.2e-07	-0.87	0.15	0.57	FALSE
17	GTEx	Brain Cortex	RP11-378A13.1	0.61	0.56	enet	23	0.61	6.7e-21	5.0	-5.3	1.2e-07	0.73	0.75	0.25	FALSE
18	GTEx	Brain Frontal Cortex BA9	RP11-378A13.1	0.38	0.54	enet	24	0.49	7.2e-15	5.0	-5.3	1.3e-07	0.72	0.78	0.22	FALSE
19	GTEx	Brain Hippocampus	RP11-378A13.1	0.43	0.24	lasso	5	0.15	2.4e-04	5.0	5.4	5.4e-08	-0.70	0.07	0.81	FALSE
20	GTEx	Brain Hypothalamus	RP11-378A13.1	0.37	0.44	enet	17	0.45	5.6e-12	5.0	-5.4	8.5e-08	0.79	0.36	0.64	FALSE
21	GTEx	Brain Nucleus accumbens basal ganglia	PNKD	0.19	0.02	lasso	5	0.05	2.1e-02	5.1	5.4	7.9e-08	-0.83	0.11	0.36	FALSE
22	GTEx	Breast Mammary Tissue	RP11-378A13.1	0.27	0.26	enet	20	0.30	1.3e-15	5.2	-5.2	2.0e-07	0.71	0.58	0.42	FALSE
23	GTEx	Breast Mammary Tissue (Female)	ARPC2	0.12	-0.01	lasso	5	-0.01	7.1e-01	5.3	-6.0	1.7e-09	0.73	0.04	0.56	FALSE
24	GTEx	Breast Mammary Tissue (Female)	RP11-378A13.1	0.30	0.11	lasso	10	0.22	3.0e-07	5.2	-5.5	3.5e-08	0.77	0.20	0.80	FALSE
25	GTEx	Cells EBV-transformed lymphocytes	TMBIM1	0.35	0.24	lasso	10	0.24	2.3e-08	5.1	-5.6	2.1e-08	0.75	0.45	0.55	FALSE
26	GTEx	Cells EBV-transformed lymphocytes	RP11-378A13.1	0.18	0.14	lasso	6	0.13	4.6e-05	5.2	-5.3	9.6e-08	0.65	0.15	0.64	FALSE
27	GTEx	Cells Transformed fibroblasts	TMBIM1	0.15	0.25	lasso	3	0.27	2.2e-20	5.2	-5.5	4.1e-08	0.63	0.52	0.48	FALSE
28	GTEx	Cells Transformed fibroblasts	RP11-378A13.1	0.29	0.26	enet	24	0.31	2.0e-23	5.2	-5.2	2.0e-07	0.68	0.60	0.40	FALSE
29	GTEx	Colon Transverse	RP11-378A13.1	0.35	0.31	lasso	6	0.43	4.6e-22	5.2	-5.2	1.8e-07	0.70	0.59	0.41	FALSE
30	GTEx	Esophagus Muscularis	RP11-378A13.1	0.37	0.42	enet	21	0.41	6.9e-27	5.0	-5.2	2.6e-07	0.76	0.81	0.19	FALSE
31	GTEx	Heart Atrial Appendage	TMBIM1	0.11	0.09	lasso	2	0.08	1.8e-04	5.2	-5.4	6.8e-08	0.63	0.47	0.43	FALSE
32	GTEx	Heart Atrial Appendage	RP11-378A13.1	0.26	0.17	enet	13	0.22	2.0e-10	5.0	-5.2	1.6e-07	0.71	0.70	0.30	FALSE
33	GTEx	Heart Left Ventricle	TMBIM1	0.12	0.08	enet	11	0.07	1.4e-04	4.7	-5.3	1.3e-07	0.69	0.31	0.66	FALSE
34	GTEx	Lung	PNKD	0.13	0.04	enet	10	0.03	3.7e-03	4.7	-5.2	1.6e-07	0.70	0.11	0.87	FALSE
35	GTEx	Lung	ARPC2	0.19	0.10	lasso	7	0.09	1.6e-07	4.8	-5.3	8.8e-08	0.69	0.80	0.20	FALSE
36	GTEx	Lung	RP11-378A13.1	0.27	0.30	enet	19	0.37	2.3e-29	5.2	-5.2	1.6e-07	0.71	0.62	0.38	FALSE
37	GTEx	Muscle Skeletal	RP11-378A13.1	0.19	0.27	enet	23	0.31	1.7e-30	5.0	-5.5	3.6e-08	0.70	0.76	0.24	FALSE
38	GTEx	Pancreas	RP11-378A13.1	0.29	0.14	enet	24	0.16	4.4e-07	5.0	-5.2	2.1e-07	0.73	0.43	0.56	FALSE
39	GTEx	Pituitary	TMBIM1	0.20	0.16	enet	13	0.02	8.4e-02	5.0	-5.2	1.5e-07	0.71	0.16	0.59	FALSE
40	GTEx	Pituitary	RP11-378A13.1	0.64	0.52	enet	19	0.52	2.7e-15	5.0	-5.2	2.1e-07	0.73	0.58	0.42	FALSE
41	GTEx	Prostate	RP11-378A13.1	0.29	0.12	enet	14	0.10	2.1e-03	5.2	-5.3	9.4e-08	0.67	0.22	0.27	FALSE
42	GTEx	Skin Not Sun Exposed Suprapubic	PNKD	0.28	0.28	enet	9	0.26	9.7e-15	5.1	-5.4	6.3e-08	0.68	0.71	0.29	FALSE
43	GTEx	Skin Not Sun Exposed Suprapubic	RP11-378A13.1	0.26	0.25	lasso	8	0.28	5.6e-16	5.0	-5.2	1.8e-07	0.68	0.69	0.31	FALSE
44	GTEx	Skin Sun Exposed Lower leg	PNKD	0.27	0.29	lasso	8	0.34	3.9e-29	5.0	-5.3	1.4e-07	0.65	0.66	0.34	FALSE
45	GTEx	Spleen	RP11-378A13.1	0.37	0.41	enet	27	0.41	1.2e-11	5.2	-5.3	1.2e-07	0.74	0.36	0.64	FALSE
46	GTEx	Testis	PNKD	0.20	0.19	lasso	3	0.19	1.2e-08	5.1	-5.3	1.2e-07	0.65	0.56	0.44	FALSE
47	GTEx	Testis	TMBIM1	0.27	0.13	enet	20	0.15	2.7e-07	5.1	-5.9	4.2e-09	0.55	0.41	0.58	FALSE
48	GTEx	Testis	RP11-378A13.1	0.37	0.18	enet	22	0.22	2.7e-10	5.1	-5.3	1.3e-07	0.69	0.61	0.39	FALSE
49	GTEx	Thyroid	ARPC2	0.10	0.03	enet	8	0.04	3.0e-04	5.3	-6.2	4.8e-10	0.75	0.07	0.90	TRUE
50	GTEx	Thyroid	RP11-378A13.1	0.31	0.34	enet	34	0.38	3.7e-30	5.0	-5.5	3.0e-08	0.76	0.74	0.26	FALSE
51	GTEx	Vagina	RP11-378A13.1	0.22	0.07	enet	11	0.03	7.1e-02	5.0	-5.5	3.9e-08	0.76	0.07	0.60	FALSE
52	GTEx	Whole Blood	PNKD	0.05	0.04	lasso	3	0.03	4.4e-04	5.0	-5.2	1.6e-07	0.71	0.25	0.65	FALSE
53	GTEx	Whole Blood	RP11-378A13.1	0.11	0.13	enet	18	0.15	1.6e-13	5.2	-5.3	1.0e-07	0.72	0.56	0.44	FALSE
54	METSIM	Adipose	AAMP	0.03	0.00	bslmm	433	0.01	7.1e-03	5.3	-5.5	2.9e-08	0.63	0.11	0.70	FALSE
55	METSIM	Adipose	TMBIM1	0.14	0.15	lasso	11	0.14	1.3e-20	5.2	-5.4	8.0e-08	0.66	0.57	0.43	FALSE
56	NTR	Blood	CXCR1	0.03	0.03	lasso	8	0.03	1.1e-08	-5.8	-5.8	4.8e-09	0.98	0.01	0.99	FALSE
57	NTR	Blood	CXCR2	0.03	0.02	lasso	2	0.02	2.9e-06	5.9	-5.9	4.1e-09	0.98	0.02	0.98	FALSE
58	ROSMAP	Brain Pre-frontal Cortex	GPBAR1	0.06	0.05	blup	430	0.05	3.2e-07	5.9	5.5	4.1e-08	-0.81	0.02	0.98	FALSE
59	YFS	Blood	CXCR1	0.11	0.14	enet	13	0.14	1.3e-44	5.0	-5.2	1.8e-07	0.90	0.80	0.19	FALSE
60	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMBIM1	0.02	0.01	blup	49	0.02	2.6e-03	5.1	-5.4	7.7e-08	0.69	0.03	0.90	FALSE
61	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TMBIM1	0.10	0.04	blup	49	0.06	3.0e-03	5.2	-5.5	3.7e-08	0.61	0.02	0.82	FALSE
62	The Cancer Genome Atlas	Soft Tissue Sarcoma	TMBIM1	0.07	0.04	blup	49	0.03	4.8e-03	5.2	-5.7	1.5e-08	0.56	0.02	0.78	FALSE
63	The Cancer Genome Atlas	Thyroid Carcinoma	TMBIM1	0.02	0.02	blup	49	0.02	9.3e-03	5.2	-5.4	8.0e-08	0.63	0.02	0.69	FALSE