[Hub]/) : Traits : Irritable Bowel Disease (IBD) :

chr2:233,227,833-234,904,144

Best TWAS P=2.21e-28 · Best GWAS P=5.41e-29 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ATG16L1 0.06 0.03 bslmm 587 0.03 3.3e-04 -2.780 7.4 1.9e-13 -0.62 0.06 0.90 FALSE
2 GTEx Adipose Subcutaneous ATG16L1 0.14 0.11 lasso 4 0.10 6.4e-09 -10.600 -10.6 4.5e-26 0.97 0.02 0.98 FALSE
3 GTEx Brain Caudate basal ganglia ATG16L1 0.21 0.09 lasso 2 0.10 6.8e-04 -8.560 -8.1 6.2e-16 0.76 0.10 0.58 FALSE
4 GTEx Brain Cerebellum ATG16L1 0.23 0.27 lasso 4 0.30 2.0e-09 -11.000 -11.0 2.2e-28 0.99 0.02 0.98 TRUE
5 GTEx Esophagus Mucosa ATG16L1 0.11 0.02 enet 10 0.00 2.3e-01 -11.100 10.3 5.4e-25 -0.88 0.02 0.90 FALSE
6 GTEx Esophagus Muscularis ATG16L1 0.11 0.03 lasso 6 0.02 2.7e-02 -9.310 -10.4 2.2e-25 0.96 0.02 0.97 FALSE
7 GTEx Nerve Tibial ATG16L1 0.24 0.18 enet 21 0.19 3.5e-13 -10.600 -9.5 1.6e-21 0.91 0.04 0.96 FALSE
8 GTEx Pituitary ATG16L1 0.36 0.16 lasso 8 0.19 1.3e-05 -6.850 -7.2 7.2e-13 0.72 0.06 0.88 FALSE
9 GTEx Skin Not Sun Exposed Suprapubic ATG16L1 0.12 0.10 enet 11 0.11 1.7e-06 -11.100 10.8 3.5e-27 -0.99 0.02 0.98 FALSE
10 GTEx Skin Sun Exposed Lower leg ATG16L1 0.21 0.08 enet 18 0.10 5.6e-09 -11.000 9.0 1.9e-19 -0.91 0.01 0.99 FALSE
11 GTEx Testis ATG16L1 0.34 0.19 enet 29 0.23 1.4e-10 -11.000 9.7 2.6e-22 -0.88 0.02 0.98 FALSE
12 METSIM Adipose INPP5D 0.05 0.01 lasso 4 0.03 6.2e-06 -0.068 -5.4 6.3e-08 0.56 0.02 0.96 FALSE
13 ROSMAP Brain Pre-frontal Cortex ATG16L1 0.28 0.26 lasso 9 0.28 3.3e-36 -4.890 -7.3 3.0e-13 0.79 1.00 0.00 FALSE
14 YFS Blood ATG16L1 0.21 0.28 lasso 7 0.30 2.2e-99 -4.850 6.6 3.5e-11 -0.73 1.00 0.00 FALSE
15 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ATG16L1 0.05 0.04 enet 12 0.05 5.4e-06 -8.750 10.0 2.3e-23 -0.82 0.02 0.98 FALSE
16 The Cancer Genome Atlas Brain Lower Grade Glioma ATG16L1 0.22 0.06 enet 36 0.10 6.2e-12 -10.600 -7.7 1.7e-14 0.70 0.03 0.97 FALSE
17 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma ATG16L1 0.11 0.05 blup 81 0.09 1.9e-04 -10.600 -9.8 9.0e-23 0.93 0.02 0.86 FALSE
18 The Cancer Genome Atlas Stomach Adenocarcinoma ATG16L1 0.07 0.04 lasso 4 0.03 3.6e-03 -6.760 6.7 1.6e-11 -0.74 0.03 0.18 FALSE
19 The Cancer Genome Atlas Thyroid Carcinoma SCARNA5 0.04 0.00 blup 55 0.02 8.2e-03 -9.310 -8.5 2.5e-17 0.74 0.02 0.50 FALSE