Hub : Genes

ATG16L1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.065 0.0250 8.3e-04 0.026 0.021 0.004 0.026 0.022 3.7e-04 1.1e-03 8.5e-02 3.3e-04 9.4e-04
2 GTEx Adipose Subcutaneous 0.140 0.0390 3.0e-06 0.108 NA 0.101 NA 0.105 3.6e-09 NA 1.4e-08 NA 6.4e-09
3 GTEx Brain Caudate basal ganglia 0.209 0.0820 5.4e-03 0.086 NA 0.062 NA 0.103 1.8e-03 NA 7.2e-03 NA 6.8e-04
4 GTEx Brain Cerebellum 0.233 0.0770 7.9e-04 0.267 NA 0.150 NA 0.297 1.6e-08 NA 3.4e-05 NA 2.0e-09
5 GTEx Esophagus Mucosa 0.110 0.0500 6.8e-03 0.015 NA 0.002 NA 0.002 3.1e-02 NA 2.3e-01 NA 2.3e-01
6 GTEx Esophagus Muscularis 0.106 0.0420 5.4e-03 0.031 NA 0.011 NA 0.018 5.4e-03 NA 7.1e-02 NA 2.7e-02
7 GTEx Nerve Tibial 0.236 0.0524 2.7e-09 0.185 NA 0.186 NA 0.162 4.3e-13 NA 3.5e-13 NA 1.4e-11
8 GTEx Pituitary 0.362 0.1090 2.1e-04 0.161 NA 0.139 NA 0.194 7.8e-05 NA 2.4e-04 NA 1.3e-05
9 GTEx Skin Not Sun Exposed Suprapubic 0.124 0.0480 2.0e-03 0.098 NA 0.108 NA 0.031 4.9e-06 NA 1.7e-06 NA 8.2e-03
10 GTEx Skin Sun Exposed Lower leg 0.208 0.0480 6.3e-08 0.078 NA 0.105 NA 0.104 5.4e-07 NA 5.6e-09 NA 6.0e-09
11 GTEx Testis 0.340 0.0760 1.7e-06 0.190 NA 0.230 NA 0.121 7.6e-09 NA 1.5e-10 NA 5.0e-06
12 ROSMAP Brain Pre-frontal Cortex 0.280 0.0449 0.0e+00 0.258 0.237 0.261 0.276 0.281 4.6e-33 4.7e-30 1.8e-33 1.3e-35 3.3e-36
13 YFS Blood 0.212 0.0269 0.0e+00 0.280 0.272 0.298 0.291 0.298 3.4e-92 2.4e-89 4.9e-99 2.4e-96 2.2e-99
14 TCGA Head and Neck Squamous Cell Carcinoma 0.052 0.0253 5.5e-05 0.045 0.027 0.047 NA 0.046 8.0e-06 4.3e-04 5.4e-06 NA 6.1e-06
15 TCGA Brain Lower Grade Glioma 0.217 0.0606 1.4e-10 0.057 0.101 0.105 NA 0.037 4.8e-07 1.6e-11 6.2e-12 NA 4.8e-05
16 TCGA Pheochromocytoma and Paraganglioma 0.114 0.0630 2.5e-03 0.047 0.090 0.068 NA 0.042 6.1e-03 1.9e-04 1.2e-03 NA 9.1e-03
17 TCGA Stomach Adenocarcinoma 0.072 0.0430 7.5e-03 0.037 0.022 0.013 NA 0.029 9.8e-04 9.6e-03 3.6e-02 NA 3.6e-03
18 TCGA Testicular Germ Cell Tumors 0.463 0.1210 5.7e-03 0.066 0.038 0.126 NA 0.143 2.3e-03 1.8e-02 3.4e-05 NA 9.4e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Bipolar Disorder (2018) 0.5 0.8 2.2 -0.6 0.8 1.1 0.8 -0.1 0.8 0.9 1.3 -0.8 -0.3 -0.7 1.1 -1.2 -0.9 0.5 1.2 -1.5 -0.1
Bipolar Disorder or Schizophrenia 0.3 0.7 2.5 0.1 0.6 1.4 0.2 0.5 0.5 0.8 0.7 -0.3 -0.6 0.3 1.5 -1.6 -0.7 0.7 0.4 -1.2 -0.0
Depressed Affect (Nagel 2018) 0.5 1.0 5.8 2.1 -0.3 -0.6 -0.6 1.5 -0.0 0.0 -0.7 0.4 0.2 0.7 0.3 -0.8 -0.4 1.1 -0.6 0.4 2.4
Depression (Nagel 2018) 1.8 2.7 6.2 2.4 -1.4 -1.6 -1.9 2.5 -1.5 -0.9 -1.2 1.8 2.2 2.5 -0.6 0.4 1.6 0.1 -1.4 2.3 0.0
Intelligence (Savage-Jansen 2018) 0.3 0.8 5.6 0.1 -0.5 0.4 -0.2 -0.2 -0.4 -0.8 -0.9 0.4 0.1 0.9 -0.8 1.4 0.7 -1.0 0.2 1.3 -2.4
Neuroticism (Nagel 2018) 0.7 1.6 4.8 2.2 -1.2 -1.1 -1.4 2.0 -1.0 -0.9 -1.5 1.4 1.1 1.2 -0.6 0.2 0.0 0.4 -1.2 1.4 1.8
Schizophrenia (2018) 0.2 0.4 1.2 0.6 0.2 0.9 -0.3 0.7 -0.1 0.2 -0.1 0.2 -0.6 1.0 1.1 -1.0 -0.1 0.6 -0.0 -0.3 -1.1
Schizophrenia vs Biploar Disorder 2.1 2.7 5.9 0.9 -2.0 -1.6 -1.7 0.9 -1.8 -2.1 -2.4 1.8 1.8 1.1 -2.2 2.4 1.0 -0.9 -1.7 1.2 0.0
Worry (Nagel 2018) 1.5 3.2 7.6 2.2 -2.0 -1.7 -1.9 2.5 -1.4 -1.8 -2.8 2.0 1.7 1.7 -1.6 1.3 0.2 0.2 -1.6 2.1 1.2
Alzheimer’s Disease (in mother) 1.0 1.2 4.9 1.7 -0.9 0.4 -1.0 1.3 -0.6 -0.0 0.9 0.7 0.2 1.2 0.7 -0.8 1.2 -2.2 -0.5 -1.0 1.6
Alzheimer’s Disease (in father) 1.4 1.6 5.0 1.3 -1.4 -1.2 -1.3 1.2 -1.1 -1.2 -1.1 1.3 1.1 1.3 -1.1 1.1 2.2 -1.2 -0.9 1.0 0.8
Alzheimer’s Disease (including proxy) 2.0 2.9 9.8 2.9 -1.5 -0.1 -1.7 2.2 -1.2 -0.8 0.0 1.4 0.7 2.4 -0.0 -0.0 2.7 -3.1 -0.9 0.7 2.3
Crohns Disease (2017) 77.2 169.4 272.2 10.7 -15.8 -11.4 -16.5 15.2 -15.7 -13.9 -9.3 16.1 13.7 14.4 -10.6 9.6 14.0 -12.1 -14.8 9.3 -4.5
Irritable Bowel Disease (IBD) 33.0 78.5 121.0 7.4 -10.6 -8.1 -11.0 10.3 -10.4 -9.5 -7.2 10.8 9.0 9.7 -7.3 6.6 10.0 -7.7 -9.8 6.7 -3.8
Ulcerative Colitis (UC) 1.4 2.6 5.7 1.5 -1.4 -1.8 -1.6 1.7 -1.3 -1.5 -2.3 1.6 1.0 1.9 -1.1 1.0 2.4 -0.6 -1.0 1.7 -2.2
Major Depression (MDD) 0.2 0.3 3.1 -0.1 0.1 -0.1 0.1 -0.3 0.0 0.3 0.1 -0.3 -0.6 -0.6 0.2 -0.6 0.0 0.0 0.2 -1.8 0.0
Reaction Time 2.1 4.0 9.6 0.5 -2.0 -1.9 -1.9 2.0 -1.6 -2.0 -3.1 2.1 2.8 1.7 -2.3 2.1 1.9 -0.5 -2.4 2.3 0.8
Verbal and Numeric Reasoning (VNR) 0.5 1.2 3.0 -1.1 1.2 1.6 1.5 -1.7 1.0 0.7 0.5 -1.2 -1.4 -0.5 0.6 0.1 -0.7 -0.4 1.7 -0.1 -1.1
Breast Cancer 2.4 5.7 10.2 1.7 -2.6 -2.2 -2.9 2.5 -2.9 -2.6 -1.9 2.9 3.0 1.9 -2.3 2.1 3.2 -1.0 -2.2 2.2 -1.2
Ovarian Cancer 0.8 1.0 3.8 1.7 -0.9 -0.2 -1.2 1.9 -0.8 -0.5 -0.0 1.1 0.8 1.3 -0.1 -0.2 0.9 -1.0 -1.5 0.5 -0.8
Prostate Cancer 0.2 0.2 1.3 0.6 0.2 0.4 0.0 0.5 0.4 -0.1 -0.0 0.1 -0.5 0.4 0.1 -0.1 -1.1 0.5 -0.0 1.0 0.8
Age at First Birth 0.2 0.2 0.9 0.9 -0.3 -0.0 -0.2 0.6 0.1 -0.5 -0.9 0.4 -0.6 0.7 -0.2 0.2 -0.1 0.1 -0.2 0.9 -0.1
Bipolar Disorder (2011) 1.3 1.2 4.8 1.8 -0.4 0.5 -0.9 2.2 -0.3 -0.1 0.8 0.9 0.4 2.1 1.0 -1.2 1.6 -0.8 -0.3 0.9 0.0
Body Mass Index (BMI) (2010) 0.1 0.2 1.1 -1.1 -0.4 -0.5 -0.4 -0.1 -0.6 -0.3 -0.0 0.4 0.4 0.0 -0.3 0.2 -0.4 0.3 -0.3 -0.2 -0.5
Coronary Artery Disease (CAD) 1.0 1.2 3.1 1.0 -1.3 -0.8 -1.5 1.8 -0.8 -0.9 -1.3 1.3 1.3 1.1 -0.5 0.1 1.3 -0.4 -1.6 0.4 -0.7
Crohns Disease (2012) 59.6 96.0 163.8 8.5 -12.2 -8.8 -12.8 12.2 -11.9 -10.6 -7.0 12.5 10.8 11.2 -8.4 7.5 0.0 -10.0 -11.4 7.7 0.0
Mean Putamen Volume 0.3 0.4 1.0 0.1 -0.5 -1.0 -0.4 0.3 -0.3 -0.6 -0.8 0.5 0.8 0.0 -0.8 0.8 -0.1 0.7 -0.3 0.9 -0.9
Fasting Glucose 0.3 0.3 1.0 0.9 -0.2 0.6 -0.1 0.8 -0.1 0.2 0.7 0.2 -0.2 0.8 0.4 -0.5 -0.0 -0.7 0.4 -1.0 -0.4
HbA1C 0.7 0.7 2.7 -0.1 0.5 0.8 1.0 -0.3 1.3 -0.4 -1.4 -0.5 -0.0 -0.2 -0.9 0.9 -0.8 0.1 1.1 0.9 1.7
HDL Cholesterol 0.5 0.8 2.0 -0.0 -1.0 -1.0 -1.4 1.1 -1.0 -0.3 0.3 0.9 1.4 0.5 0.1 -0.4 1.2 -0.9 -1.0 -1.2 -0.5
LDL Cholesterol 0.1 0.2 1.0 0.7 0.2 0.3 0.5 -1.0 0.1 -0.1 0.5 -0.3 -0.4 -0.8 -0.0 0.4 -0.4 0.1 0.4 -0.3 -0.2
Lupus 0.1 0.1 0.8 -0.0 0.1 0.4 0.2 -0.1 0.4 0.2 0.4 -0.2 -0.9 0.1 0.5 -0.2 0.1 -0.3 0.3 -0.7 0.5
Neuroticism (2016) 0.5 0.7 4.1 1.0 0.4 -0.8 -0.3 0.5 0.5 0.5 -0.1 0.0 0.0 0.2 0.5 -0.7 -1.8 1.6 0.1 0.4 2.0
Primary Biliary Cirrhosis 3.0 4.3 7.8 -0.3 -2.1 -1.4 -1.8 1.2 -2.2 -2.4 -2.0 2.1 2.8 1.1 -2.8 2.7 2.7 -2.2 -1.6 2.5 -1.6
Rheumatoid Arthritis 0.2 0.3 1.1 1.0 0.1 0.8 -0.1 0.1 0.0 0.2 0.8 -0.0 -0.1 0.4 0.8 -0.9 0.8 -0.9 0.0 -0.3 -0.6
Schizophrenia (2014) 0.1 0.2 1.3 -0.1 -0.2 0.3 -0.4 0.6 -0.3 -0.4 -1.1 0.4 -0.1 0.7 -0.0 0.2 -0.1 0.3 -0.2 0.1 -0.1
Triglycerides 0.5 0.8 2.1 1.2 -0.9 -0.3 -0.4 0.6 -0.8 -1.3 -1.1 0.7 0.5 0.6 -1.4 1.4 0.0 -0.8 -0.3 1.2 -0.9
Type 2 Diabetes (T2D) (2012) 0.4 0.5 2.3 0.9 -0.2 0.5 -0.2 0.9 0.3 -0.3 0.3 0.3 0.3 1.3 0.4 -0.5 1.5 -1.2 -0.3 0.1 -0.1
Ulcerative Colitis 1.9 2.7 5.3 1.0 -1.7 -1.9 -1.7 1.7 -1.7 -1.7 -2.3 1.8 1.3 1.3 -1.4 1.3 2.2 -0.8 -2.0 1.4 -1.5
Blood Eosinophil Count 0.5 4.1 11.5 -2.1 1.9 1.5 1.8 -2.6 0.9 2.9 3.4 -2.0 -2.3 -2.1 1.6 -1.8 -1.2 -0.7 2.1 -0.5 2.5
Blood Platelet Count 1.1 13.2 28.5 -1.9 4.5 4.5 4.3 -3.3 4.4 4.2 5.3 -4.1 -3.4 -2.2 3.9 -3.6 -2.4 2.5 4.5 -1.7 1.1
Blood Red Count 0.1 1.4 4.8 1.1 -1.5 -2.2 -1.5 1.2 -1.5 -1.1 -1.7 1.3 0.6 1.0 -1.2 0.8 0.2 0.2 -0.8 0.6 0.7
Blood White Count 0.3 2.3 5.2 -1.9 1.6 1.9 1.8 -1.5 1.6 1.1 1.6 -1.6 -1.4 -1.0 1.0 -0.7 -2.3 1.2 1.7 -1.1 1.1
Heel T-Score 0.0 0.4 2.1 -1.4 0.7 0.6 0.5 -0.4 0.2 0.2 0.3 -0.4 0.4 -0.5 0.1 -0.3 -0.9 0.1 1.2 0.3 -0.2
BMI 0.2 1.0 7.3 -1.0 0.8 0.6 0.7 -0.9 0.4 0.7 1.2 -0.8 -0.6 -1.1 0.8 -0.9 -0.3 0.1 0.9 -0.3 -2.7
Height 0.6 11.4 18.7 -3.7 4.1 3.0 4.3 -4.1 3.9 3.0 2.6 -4.0 -3.8 -2.8 2.2 -1.7 -4.1 3.5 4.2 -1.2 2.0
Waist Hip Ratio (WHR) 0.7 3.0 6.7 -0.3 -1.8 -2.6 -1.6 0.9 -2.0 -2.1 -1.8 1.7 1.8 0.5 -2.4 2.5 1.8 -1.0 -1.6 1.8 -0.2
Systolic Blood Pressure 0.2 1.1 4.9 0.7 -1.2 -1.8 -1.4 1.1 -0.9 -0.2 -0.7 1.1 0.5 0.7 -0.3 0.3 -0.9 0.8 -1.2 0.3 2.2
Smoking Status 0.9 2.1 4.1 -1.0 1.8 1.7 1.4 -0.5 1.7 1.8 1.0 -1.4 -1.4 -0.7 1.9 -2.0 -1.4 1.9 1.5 -0.4 1.0
Allergy or Eczema 2.7 7.1 15.0 0.4 -3.0 -2.5 -2.8 1.5 -3.5 -2.8 -1.7 2.9 2.9 1.8 -3.1 3.4 2.8 -3.9 -2.5 2.9 1.0
Cardiovascular Disease 3.4 11.3 18.1 2.3 -4.1 -4.1 -4.3 3.6 -4.2 -3.3 -3.3 4.2 3.8 3.2 -3.1 2.7 2.8 -1.0 -3.9 3.2 -0.1
Hypothyroidism (self reported) 0.2 0.5 2.1 0.7 -0.3 0.4 -0.6 0.4 -0.7 -0.7 0.3 0.6 1.1 1.1 0.1 0.1 1.5 0.0 -0.1 0.7 -1.2
Respiratory disease 0.2 0.5 1.9 0.7 -0.4 0.9 -0.6 0.8 -0.7 0.1 0.7 0.6 0.9 0.8 0.6 -0.7 1.1 -1.4 -0.4 -0.1 -0.1
Type 2 Diabetes (T2D) (2018) 1.7 3.2 8.3 0.4 2.1 2.2 2.1 0.1 2.9 2.1 2.2 -1.8 -1.2 -0.4 2.2 -2.2 -1.7 1.2 2.1 -0.5 1.4
Lung FEV1/FVC ratio 0.7 3.5 7.1 -0.4 -1.9 -0.9 -1.9 0.7 -2.5 -2.7 -2.2 2.0 2.2 0.9 -2.4 2.3 2.4 -1.6 -2.0 1.6 -0.7
Lung FVC 0.2 1.0 9.1 3.0 -0.5 -1.2 -0.5 1.3 0.5 -0.4 -1.5 0.4 0.5 0.7 0.1 -0.3 -0.1 1.0 -0.9 0.7 0.0
Neuroticism 1.2 2.9 8.6 2.9 -1.6 -1.0 -1.9 2.4 -1.6 -1.5 -1.7 1.9 1.7 1.9 -1.0 0.7 0.9 -0.6 -1.8 2.1 1.8
Chronotype (morning person) 0.6 1.4 4.4 -0.7 1.4 0.8 1.3 -2.1 1.1 1.2 0.9 -1.4 -1.6 -1.4 0.9 -0.8 -0.3 1.1 1.3 -1.2 0.7
Hair Pigment 0.1 1.5 3.3 1.8 -1.7 -1.5 -1.8 1.6 -1.7 -0.9 -0.6 1.4 -0.1 1.6 -0.4 0.0 0.0 -1.0 -1.7 0.1 0.8
Tanning 0.1 1.7 4.5 -2.1 1.2 1.6 1.1 -0.7 1.3 1.6 2.1 -1.0 -1.0 0.3 1.6 -1.3 0.1 0.9 1.2 0.7 -1.3
Hand grip strength (left) 0.1 0.2 1.0 -0.2 0.3 -0.4 0.3 -0.3 0.5 0.1 -0.6 -0.3 -0.0 -0.8 -0.2 0.0 -0.9 1.0 -0.2 0.1 0.6
Number of treatments/medications taken 0.7 1.3 3.1 0.9 -1.3 -1.1 -1.5 1.8 -1.4 -1.1 -0.6 1.5 1.6 1.2 -0.8 0.5 0.9 -0.3 -1.3 1.1 -0.8
Average weekly spirits intake 0.5 0.6 1.2 0.5 -0.8 -1.1 -0.6 0.8 -0.5 -0.4 -0.9 0.7 1.1 1.0 -0.8 0.7 0.8 -0.4 -0.4 1.0 -0.9
Sensitivity / hurt feelings 0.2 0.3 1.2 0.3 0.3 0.6 -0.4 0.4 -0.3 0.6 1.1 0.2 -0.4 0.2 0.8 -0.9 0.2 0.0 -0.1 0.3 0.7
Frequency of depressed mood in last 2 weeks 2.3 3.3 8.4 2.7 -1.7 -1.3 -2.1 2.9 -1.5 -0.8 -1.4 2.0 2.2 2.9 -0.5 0.1 1.1 -0.5 -1.8 2.1 1.7
Hearing difficulty/problems: Yes 0.3 0.5 1.3 0.5 -0.3 -0.2 -0.4 0.9 -0.3 -0.8 -1.0 0.5 0.8 0.9 -0.6 0.3 0.9 -0.5 -0.7 1.1 1.1
Relative age of first facial hair 2.0 4.0 8.1 2.0 -2.1 -1.9 -2.2 2.4 -1.7 -2.1 -2.6 2.2 2.0 2.6 -1.9 1.5 1.3 -0.4 -2.1 2.9 0.4
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 1.9 1.1 -0.8 -0.6 -0.9 1.4 -0.5 -0.6 -0.9 0.9 1.0 1.2 -0.4 0.2 0.8 0.1 -1.0 0.8 0.2
Ever used hormone-replacement therapy (HRT) 3.2 4.1 7.2 -0.6 2.4 2.2 2.3 -1.4 2.6 2.4 2.7 -2.3 -2.1 -1.5 2.4 -2.4 -1.5 1.2 2.4 -1.7 0.2
Ever had hysterectomy (womb removed) 0.4 0.4 3.6 -0.7 -0.1 -0.2 -0.1 -0.8 -0.8 -0.6 0.3 0.1 -0.4 0.1 -0.3 1.0 0.4 -1.9 0.2 0.1 -0.5
Systolic blood pressure, automated reading 0.0 0.1 0.4 -0.3 0.1 -0.4 0.1 -0.2 0.4 0.4 0.5 -0.2 -0.6 0.0 0.6 -0.3 -0.2 0.4 0.2 -0.6 0.0
Eye problems/disorders: Diabetes related eye disease 2.1 2.3 5.6 -0.9 1.8 1.3 1.9 -0.8 2.1 1.9 2.4 -1.8 -1.5 -0.9 1.7 -1.4 -0.7 1.0 1.9 -1.0 -0.2
Angina 1.1 1.4 4.1 0.8 -1.5 -1.0 -1.6 1.9 -1.5 -1.0 -0.5 1.6 0.8 0.8 -0.7 0.4 1.6 -1.2 -2.0 0.2 0.4
Medication for hormone replacement therapy 1.2 1.3 3.7 -0.2 1.4 1.9 1.3 -0.4 1.3 1.2 1.1 -1.1 -0.9 -0.4 1.5 -1.4 -1.4 1.1 1.1 -0.5 0.8
Vitamin and mineral supplements 0.2 0.3 1.1 -0.9 0.4 0.3 0.6 -1.0 0.2 0.2 0.4 -0.5 -0.8 -0.4 -0.2 0.2 0.6 -0.1 0.5 0.7 0.8
Supplements: Zinc 0.7 0.7 2.2 -0.5 -1.0 -0.8 -1.2 0.2 -1.5 -0.8 -0.0 1.0 1.1 0.4 -0.4 0.6 0.8 -1.2 -0.6 0.3 -1.2
Medication: Co-codamol 1.6 1.9 5.4 0.5 -1.3 -1.5 -1.4 1.2 -1.2 -1.4 -1.1 1.5 1.7 2.1 -1.4 1.5 1.1 0.1 -1.1 2.3 -1.0
Medication: Metformin 1.2 1.7 4.9 -0.3 1.6 1.6 1.7 -0.3 2.2 1.6 1.8 -1.5 -1.0 -0.5 1.4 -1.6 -0.2 0.5 1.6 -0.5 0.6
Diabetes (father) 0.6 0.7 3.1 1.2 -0.2 1.3 -0.5 1.3 0.1 0.1 0.6 0.4 -0.1 1.3 0.9 -1.0 0.3 -1.8 0.3 -0.3 -0.5
Diabetes (mother) 1.3 1.7 5.2 1.0 -1.4 -1.1 -1.4 1.4 -1.1 -1.1 -0.8 1.4 1.4 1.4 -1.2 1.1 2.3 -1.4 -1.1 1.3 -0.9
Severe depression (siblings) 1.2 1.4 3.0 -0.4 -1.3 -1.4 -1.1 0.2 -1.4 -1.4 -1.7 1.1 1.4 0.6 -1.6 1.5 0.8 -0.9 -1.7 0.7 -0.6
Pack years adult smoking proportion 0.2 0.3 0.9 -0.7 0.5 -0.0 0.5 -0.8 0.4 0.2 -0.5 -0.6 -0.8 -0.5 0.4 -0.1 -0.7 0.6 0.6 -0.9 -0.4
Impedance of leg (right) 1.1 5.3 9.8 0.9 -2.6 -3.1 -2.5 1.9 -2.3 -2.9 -3.0 2.5 2.6 1.7 -2.9 2.9 1.3 -1.1 -2.3 2.0 -0.3
Leg fat-free mass (left) 0.9 4.7 8.2 -1.1 2.5 2.7 2.5 -1.8 2.5 2.7 2.6 -2.4 -2.9 -1.6 2.5 -2.7 -1.4 0.9 2.5 -1.3 0.2
Trunk fat percentage 0.2 1.0 15.4 -0.6 -0.1 -0.4 -0.2 -0.2 -0.4 -0.1 0.3 0.2 -0.2 -0.2 -0.0 -0.1 1.0 0.1 0.3 0.5 -3.9
Hand grip strength (right) 0.3 0.7 1.5 1.2 -0.6 -1.1 -0.7 0.9 -0.3 -0.7 -1.1 0.7 0.7 0.3 -0.8 0.6 -0.2 0.7 -1.0 1.2 1.1
Townsend deprivation index at recruitment 0.2 0.3 1.5 0.6 0.3 -0.5 -0.0 0.2 0.1 0.2 -0.7 0.1 -0.4 0.8 0.1 -0.4 0.2 0.5 -0.9 1.2 1.1
Current tobacco smoking 0.7 1.2 6.3 0.8 1.0 1.2 0.8 0.6 1.5 1.2 -0.3 -0.7 -0.4 0.1 1.3 -1.6 -1.3 1.0 0.6 0.2 2.5
Average weekly fortified wine intake 1.2 1.4 2.8 0.8 -1.4 -0.9 -1.4 1.1 -1.6 -1.0 -0.2 1.4 1.7 1.2 -1.0 0.9 1.6 -1.2 -1.4 0.6 -0.2
Maternal smoking around birth 0.1 0.2 1.7 0.4 0.4 -0.2 0.4 -0.2 0.4 0.6 0.2 -0.4 -0.0 -0.4 0.3 -0.6 -0.4 -0.3 -0.2 -0.1 1.3
Fed-up feelings 0.6 1.1 3.4 1.8 -0.8 -0.7 -1.4 1.9 -0.8 -0.3 -0.5 1.1 0.9 1.0 0.1 -0.6 0.1 0.0 -1.1 0.7 1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.5 1.2 0.3 0.2 -0.1 0.8 0.3 0.9 0.1 0.0 -0.0 1.0 0.9 -1.2 0.1 1.0 0.2 0.8 1.2
Relative age voice broke 5.0 7.7 12.2 2.4 -3.4 -2.2 -3.2 3.5 -2.7 -3.2 -2.6 3.3 2.7 3.4 -2.8 2.2 2.8 -1.8 -2.9 2.7 0.3
Taking other prescription medications 0.2 0.3 1.2 0.6 -0.1 0.4 -0.2 0.7 -0.1 0.6 1.1 0.3 -0.1 0.9 0.7 -1.0 0.5 0.4 -0.1 0.5 0.2
Age when periods started (menarche) 0.2 0.5 1.5 0.2 -0.8 -0.0 -0.9 0.5 -1.2 -0.7 0.2 1.1 1.2 0.8 -0.7 0.5 0.2 0.5 -0.7 0.5 0.3
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.7 -0.6 0.7 -0.0 0.7 -0.8 0.6 0.3 0.8 -0.8 -0.4 -0.3 0.4 -0.0 0.0 -0.4 0.2 -0.1 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 1.2 0.4 0.5 1.1 0.1 0.0 0.2 0.6 0.7 -0.1 0.0 0.1 0.8 -1.0 -0.1 0.3 0.2 -0.1 -0.0
Tinnitus: Yes, but not now, but have in the past 3.1 3.3 6.0 0.9 -2.2 -1.8 -2.0 2.0 -1.8 -1.9 -1.0 2.1 2.4 1.9 -2.1 1.8 1.7 -2.2 -1.2 1.7 -0.4
Qualifications: CSEs or equivalent 0.2 0.3 1.0 -0.9 0.3 -0.8 0.4 -1.0 -0.1 0.3 0.0 -0.4 -0.8 -0.7 -0.4 0.3 -0.7 -0.1 -0.4 -0.0 0.8
Serious illness, injury or assault to yourself 1.5 1.8 3.8 -1.9 1.3 0.7 1.5 -1.6 1.2 1.4 0.8 -1.5 -1.3 -2.0 0.6 -0.7 -1.7 1.5 1.0 -0.9 1.7
High blood pressure 2.8 7.9 13.0 1.5 -3.3 -3.6 -3.5 3.1 -3.3 -2.7 -2.8 3.4 3.1 2.8 -2.6 2.2 2.8 -0.6 -3.4 2.9 0.2
Hayfever, allergic rhinitis or eczema 3.1 6.8 12.0 1.1 -2.9 -2.7 -2.9 1.9 -3.2 -2.8 -2.6 3.0 2.6 2.2 -3.0 3.1 2.2 -2.2 -2.7 3.5 1.3
Multivitamins +/- minerals 0.2 0.3 1.0 0.9 -0.4 -0.7 -0.5 0.7 -0.3 -0.6 -1.0 0.5 0.8 0.4 -0.3 0.3 -0.3 0.1 -0.7 0.0 -0.1
Stomach or abdominal pain in last month 0.2 0.3 1.4 -0.1 0.5 0.7 0.5 -0.5 0.5 0.4 -0.4 -0.5 -0.1 -0.4 0.4 -0.5 -1.2 0.6 0.4 -0.5 0.1
Supplements: Glucosamine 0.8 1.1 2.9 -1.2 1.1 0.5 0.9 -1.7 0.4 1.1 1.1 -1.2 -0.6 -1.4 0.9 -0.9 -0.7 0.8 0.9 -1.5 -0.1
Diverticular disease/diverticulitis (self-reported) 0.9 1.1 3.4 0.4 -1.2 -1.8 -1.1 -0.0 -1.4 -0.9 -1.4 0.8 0.8 -0.4 -1.1 1.1 0.3 -1.1 -1.7 0.3 -0.2
Medication: Atenolol 0.2 0.2 1.3 0.1 -0.1 -0.9 -0.3 -0.1 -0.5 -0.1 0.2 0.2 -0.4 0.1 0.1 -0.0 0.3 0.4 -0.6 0.1 -1.1
Medication: Levothyroxine sodium 0.1 0.2 1.3 -0.0 0.2 -0.1 0.1 -0.0 -0.1 -0.6 0.3 0.1 0.4 0.5 -0.3 0.4 1.0 0.2 0.4 1.1 0.2
Sitting height 0.1 0.8 2.5 0.3 0.7 0.8 0.5 -0.0 0.9 1.2 1.6 -0.6 -1.4 0.9 1.2 -1.4 -0.2 0.0 0.8 -0.1 0.8
Chronic bronchitis/emphysema (father) 0.5 0.6 3.1 0.4 -0.5 -0.4 -0.6 0.4 -0.9 -0.5 0.1 0.7 0.4 1.2 -0.4 0.4 1.8 -0.2 -0.6 1.2 -1.4
High blood pressure (mother) 1.4 1.9 3.4 1.0 -1.7 -1.3 -1.9 1.8 -1.6 -1.3 -0.6 1.7 1.7 1.8 -0.6 0.5 1.6 -1.6 -1.3 0.5 -1.1
Body mass index (BMI) 0.3 1.1 7.8 -0.7 0.8 0.9 0.7 -0.7 0.5 0.9 1.4 -0.8 -0.9 -0.6 1.0 -1.2 0.5 -0.4 1.0 -0.2 -2.8
Impedance of leg (left) 0.5 2.3 5.7 -0.5 -1.6 -2.4 -1.5 0.6 -1.6 -2.0 -2.0 1.5 1.8 0.5 -2.1 2.2 0.4 -0.3 -1.4 1.0 -0.6
Leg predicted mass (left) 0.9 4.7 8.1 -1.0 2.5 2.7 2.5 -1.7 2.5 2.8 2.6 -2.4 -2.8 -1.5 2.5 -2.8 -1.3 0.9 2.4 -1.2 0.2
Trunk fat mass 0.3 1.2 11.4 -1.2 0.8 0.4 0.7 -0.9 0.5 0.7 1.0 -0.7 -1.0 -0.8 0.6 -0.8 0.3 0.4 1.1 -0.0 -3.4
Waist circumference 0.2 0.6 6.2 -0.9 0.2 0.1 0.1 -0.2 -0.2 0.2 1.0 -0.1 -0.3 -0.1 0.2 -0.3 1.2 -0.1 0.5 0.6 -2.5
Number of incorrect matches in round 1.7 2.8 6.0 0.8 -1.6 -1.8 -1.5 1.3 -1.7 -2.1 -1.9 1.7 2.0 0.9 -2.2 2.3 0.7 -0.7 -1.8 2.5 0.3
Past tobacco smoking 0.7 1.2 2.2 1.3 -1.4 -1.0 -1.1 1.0 -1.2 -1.4 -0.8 1.1 1.1 0.5 -1.1 1.2 0.7 -1.2 -1.2 0.1 1.5
Alcohol usually taken with meals 0.6 0.9 4.3 -1.3 0.7 0.8 0.6 -1.3 0.4 0.8 1.0 -0.8 -0.6 -0.7 0.9 -0.7 -0.1 -0.0 0.6 -1.7 -2.1
Nervous feelings 2.2 4.0 9.5 1.6 -2.1 -2.3 -2.1 2.0 -1.8 -2.1 -3.1 2.2 2.4 1.9 -2.2 1.9 -0.0 -0.1 -2.2 2.5 0.9
Frequency of tenseness / restlessness in last 2 weeks 2.2 3.4 7.2 2.6 -1.7 -1.3 -2.1 2.5 -1.7 -1.1 -2.2 2.1 1.8 2.7 -0.8 0.4 1.2 -0.8 -2.1 1.9 2.1
Hearing difficulty/problems with background noise 1.8 2.9 5.3 1.5 -1.6 -1.8 -1.6 1.4 -1.7 -2.0 -2.3 1.8 1.4 1.6 -2.1 1.8 1.8 -1.2 -1.8 2.2 0.3
Hair/balding pattern: Pattern 2 2.0 2.6 5.0 -2.2 1.5 0.7 1.7 -1.5 1.5 1.6 2.0 -1.8 -1.6 -1.9 1.0 -1.2 -2.0 1.1 1.6 -2.2 -0.2
Had menopause 1.4 1.7 4.6 -0.6 1.5 1.6 1.3 -1.1 1.4 1.4 2.1 -1.3 -1.0 -0.5 1.7 -1.6 -0.8 1.4 1.1 -1.3 0.9
Had other major operations 0.5 0.6 1.6 1.2 -0.4 -0.3 -0.5 0.8 -0.5 -0.4 0.5 0.5 -0.2 1.2 -0.3 0.2 1.3 -1.2 -1.2 0.8 0.9
Forced vital capacity (FVC) 0.4 1.4 5.3 0.6 1.2 0.5 1.4 -0.7 1.8 1.2 0.2 -1.3 -1.6 -1.0 0.7 -0.6 -1.5 1.1 1.2 0.2 2.3
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 1.2 0.6 -0.3 0.3 -0.8 0.8 -0.7 -0.5 -0.1 0.7 1.1 1.0 -0.0 -0.0 1.0 -0.4 -0.7 1.0 -0.1
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 1.3 -0.6 -0.1 0.2 -0.2 0.2 -0.4 -0.3 -0.2 0.2 0.7 -0.1 -0.0 -0.0 -0.2 -0.8 -0.2 -0.7 1.1
Qualifications: None of the above 0.1 0.1 0.9 0.9 -0.0 -0.1 -0.2 0.7 -0.0 -0.2 -0.2 0.2 -0.1 0.2 0.2 -0.3 0.0 -0.3 -0.2 -0.3 0.5
Financial difficulties in last 2 years 1.6 2.2 6.0 1.6 -1.5 -1.5 -1.7 2.1 -1.5 -1.1 -1.2 1.6 1.7 1.4 -1.0 0.7 1.4 -0.9 -2.5 1.3 1.0
Mouth/teeth dental problems 1.0 1.6 6.0 1.6 -1.3 0.3 -1.4 1.6 -1.2 -1.1 -0.3 1.3 1.1 1.1 -0.4 0.2 2.1 -2.4 -0.4 0.0 -1.4
Heart attack 1.4 1.8 4.2 1.3 -1.3 -1.0 -1.6 1.5 -1.5 -1.6 -1.5 1.6 1.1 1.1 -0.9 1.2 0.9 -0.8 -2.0 1.6 0.8
Allergy 1.9 4.5 7.3 -0.7 2.3 1.9 2.5 -1.8 2.7 2.0 1.8 -2.5 -2.3 -2.2 2.2 -2.2 -2.0 2.0 2.1 -2.7 -1.1
Pain all over the body in last month 2.3 2.5 4.4 -0.2 1.5 2.0 1.4 -1.2 1.6 2.0 1.8 -1.6 -1.8 -0.9 2.1 -2.0 -1.1 -1.7 1.2 -1.6 1.4
Diabetes (self-reported) 0.4 0.6 2.6 0.8 0.9 1.0 0.9 0.7 1.6 0.7 1.0 -0.6 -0.2 0.3 0.9 -0.9 -0.1 0.1 0.9 0.4 0.2
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 2.4 -0.3 -0.7 -0.4 -0.5 0.1 -0.9 -0.6 -0.0 0.7 0.6 0.5 -0.9 1.0 0.4 -1.0 -0.4 1.2 1.5
Medication: Ramipril 1.2 1.5 6.2 -2.5 0.9 0.4 0.8 -1.3 0.4 1.1 0.4 -0.9 -0.2 -2.0 0.7 -0.7 -1.9 1.9 0.5 -1.7 0.5
Medication: Simvastatin 0.2 0.3 0.8 0.2 0.7 0.2 0.8 -0.1 0.9 0.6 0.6 -0.6 -0.6 -0.6 0.5 -0.4 -0.8 0.4 0.6 0.1 0.9
Fluid intelligence score 0.3 0.6 4.5 0.5 0.5 0.3 0.9 -1.0 0.8 0.2 -0.2 -0.7 -1.1 0.1 0.0 0.4 0.5 -0.3 0.7 0.2 -2.1
Illnesses of siblings 2.4 3.4 6.5 -1.1 2.1 2.1 2.2 -1.7 2.5 1.8 1.1 -2.2 -2.0 -1.6 1.7 -1.6 -1.9 1.8 2.5 -1.1 -0.4
Neuroticism score 1.3 2.7 7.5 2.7 -1.4 -1.0 -1.8 2.4 -1.3 -1.1 -1.9 1.8 1.4 1.9 -0.8 0.3 0.6 -0.5 -1.7 1.8 2.4
Weight 0.6 2.7 5.3 -1.5 1.8 1.7 1.7 -1.5 1.5 1.9 2.3 -1.7 -2.0 -1.3 1.8 -1.9 -0.4 0.2 1.9 -0.9 -1.8
Impedance of arm (right) 1.1 5.1 9.1 1.2 -2.7 -2.8 -2.7 2.1 -2.5 -2.7 -3.0 2.6 2.0 1.8 -2.6 2.6 1.7 -1.0 -2.5 1.7 0.2
Arm fat percentage (right) 0.3 1.1 14.4 -0.3 -0.4 -0.3 -0.5 0.4 -0.7 -0.2 0.4 0.4 0.1 0.2 -0.0 -0.2 1.4 -1.0 0.0 0.4 -3.8
Trunk fat-free mass 0.6 3.4 6.1 -1.5 2.1 2.4 2.1 -1.6 2.0 2.3 2.5 -2.0 -2.0 -1.2 2.0 -2.3 -1.4 0.1 2.0 -1.2 0.9
Hip circumference 0.3 1.3 3.4 -1.0 1.2 1.0 0.9 -0.7 0.9 1.5 1.7 -1.0 -1.2 -0.5 1.4 -1.6 -0.1 0.6 1.3 -0.2 -1.9
Time employed in main current job 0.1 0.1 0.3 -0.6 0.3 0.4 0.2 0.2 0.4 -0.0 -0.4 -0.1 0.4 -0.3 0.3 -0.0 -0.4 0.5 0.3 0.5 0.3
Alcohol intake versus 10 years previously 0.8 1.2 3.4 -0.3 -1.2 -1.6 -0.9 0.4 -1.2 -1.1 -0.2 1.1 0.3 0.7 -1.7 1.9 1.4 -0.8 -1.1 1.2 -0.6
Father’s age at death 0.1 0.2 0.7 0.8 -0.0 0.6 0.2 -0.0 0.3 -0.5 -0.4 -0.0 -0.2 0.4 -0.1 0.6 0.2 -0.8 0.5 0.4 0.2
Worrier / anxious feelings 1.1 2.1 6.2 2.3 -1.3 -1.3 -1.5 1.9 -0.9 -1.4 -2.1 1.6 0.8 1.3 -1.4 1.2 0.8 0.6 -1.1 2.5 0.5
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 3.6 1.5 0.5 1.0 -0.2 1.1 0.4 0.9 0.4 -0.0 -0.0 1.2 1.6 -1.9 -0.3 -0.5 0.0 0.1 0.6
Falls in the last year 1.1 1.5 3.8 1.0 -1.4 -0.5 -1.6 1.9 -1.5 -0.8 -0.2 1.6 1.5 1.7 -0.3 -0.0 0.6 -1.6 -1.4 0.5 0.9
Hair/balding pattern: Pattern 3 0.6 0.8 4.8 1.0 -0.7 0.4 -0.8 0.6 -1.2 -0.6 0.3 0.7 -0.1 0.5 0.1 -0.2 1.0 -2.2 -0.8 -0.8 -1.6
Number of live births 0.4 0.5 4.1 0.5 0.3 -0.1 0.2 0.9 0.7 0.4 1.0 -0.1 0.1 0.5 0.5 -0.7 0.4 0.7 0.6 0.8 -2.0
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 2.1 0.3 0.9 0.7 1.1 -0.6 1.3 0.8 0.1 -1.0 -1.1 -1.0 0.5 -0.4 -1.1 0.7 0.9 0.1 1.5
Pulse rate 0.7 1.2 2.8 0.0 -1.1 -1.2 -1.1 0.7 -1.1 -1.2 -1.2 1.1 1.6 0.8 -1.3 1.3 1.2 -0.4 -0.5 1.0 -1.7
Happiness 3.7 4.5 8.8 2.3 -2.1 -1.9 -2.3 2.7 -1.8 -1.8 -2.5 2.4 2.3 2.2 -1.9 1.4 0.5 -0.4 -2.3 3.0 2.5
Noisy workplace 0.9 1.1 3.1 -0.6 0.7 0.5 0.9 -0.1 1.0 1.2 1.1 -0.9 -0.6 -1.2 0.9 -1.4 -1.1 1.8 1.2 -1.6 0.9
Qualifications: A levels/AS levels or equivalent 0.2 0.3 1.9 1.4 -0.3 0.3 -0.2 0.3 -0.0 -0.6 -0.7 0.3 -0.3 0.9 -0.5 0.7 0.1 -0.8 0.4 0.5 -0.6
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.4 3.6 -1.5 1.2 1.4 1.4 -1.3 1.4 0.7 0.9 -1.3 -0.9 -1.9 0.7 -0.7 -1.5 1.2 0.9 -1.1 -0.4
Mouth/teeth dental problems: Dentures 0.4 0.6 1.6 -1.0 0.9 -0.4 1.2 -1.2 0.8 0.5 0.7 -1.0 -0.6 -1.3 -0.2 0.4 -1.0 0.7 0.4 -0.2 -0.1
Asthma 2.1 4.2 7.0 2.0 -2.1 -0.8 -2.5 2.5 -2.5 -1.7 -0.7 2.5 2.4 2.6 -1.2 0.9 2.6 -2.3 -2.4 2.1 -0.9
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 7.6 1.2 -0.4 -1.1 -0.3 0.3 -0.5 -1.0 -2.8 0.5 0.6 0.1 -1.5 1.6 0.5 0.3 -1.1 2.0 1.5
Medication: Cholesterol lowering 0.1 0.2 1.7 1.3 0.1 -0.5 0.2 0.3 0.3 0.1 -0.5 -0.0 -0.4 -0.2 0.0 -0.2 -0.5 0.6 -0.1 0.2 -0.0
Depression (self-reported) 0.8 1.0 4.8 1.7 -0.6 -0.2 -0.9 1.0 -0.6 -0.3 -0.6 0.9 0.8 1.7 -0.3 0.1 1.1 0.0 -0.5 2.2 0.9
Medication: Lansoprazole 0.3 0.4 1.8 1.4 -0.4 -1.0 -0.5 0.8 -0.3 0.0 -0.2 0.4 0.5 0.4 -0.1 -0.3 0.2 0.2 -1.1 0.1 0.7
Prospective memory result 0.3 0.3 2.0 -0.2 -0.1 0.5 -0.6 0.5 -0.5 -0.1 0.8 0.4 0.9 0.2 0.7 -0.5 -0.3 -0.2 -0.6 0.1 1.4
Lung cancer (father) 1.1 1.3 6.6 2.1 -0.9 -0.7 -1.2 1.9 -0.8 -0.3 -0.4 1.0 0.1 1.1 0.5 -0.7 0.0 -0.5 -0.9 -0.9 2.6
Illnesses of mother 0.9 1.2 4.7 -2.2 1.0 0.3 1.4 -2.1 0.8 0.4 -0.1 -1.2 -0.7 -1.3 -0.4 0.6 -1.3 1.1 1.0 -0.0 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 1.3 0.6 0.5 0.3 0.7 -0.4 1.0 0.5 -0.1 -0.6 -1.1 -0.8 0.3 -0.3 -0.9 0.5 0.6 -0.2 0.4
Pulse wave Arterial Stiffness index 0.7 0.8 2.7 0.7 -0.8 0.2 -1.3 1.0 -1.4 -0.4 0.6 1.1 0.9 1.1 0.3 -0.1 1.7 -1.0 -1.0 0.4 -0.4
Impedance of arm (left) 0.4 1.7 3.2 1.1 -1.5 -1.6 -1.6 1.4 -1.4 -1.5 -1.8 1.6 1.0 1.0 -1.4 1.4 0.9 0.0 -1.5 0.8 0.0
Arm fat mass (right) 0.2 0.9 9.2 -0.7 0.5 0.6 0.4 -0.3 0.3 0.7 1.2 -0.5 -0.7 -0.3 0.8 -1.0 0.6 -0.6 0.8 0.0 -3.0
Trunk predicted mass 0.6 3.4 5.9 -1.5 2.1 2.4 2.1 -1.6 2.0 2.3 2.4 -2.0 -2.0 -1.2 2.0 -2.2 -1.4 0.1 2.0 -1.1 1.0
Standing height 0.3 3.3 5.7 -1.7 2.0 1.8 2.0 -1.8 2.2 2.0 2.0 -2.0 -2.4 -1.2 1.6 -1.6 -1.7 1.2 2.0 -1.2 1.8
Length of working week for main job 0.9 1.0 2.5 -0.0 -0.9 -1.2 -0.7 -0.1 -1.1 -1.0 -1.4 0.8 1.1 0.3 -1.3 1.6 0.5 -1.1 -0.9 1.2 0.9
Exposure to tobacco smoke at home 0.8 0.9 3.0 -0.8 1.3 0.7 1.1 -0.5 1.4 0.6 0.0 -1.1 -0.9 -0.5 0.7 -0.7 -1.6 1.7 1.0 -0.3 0.6
Breastfed as a baby 4.5 5.5 10.1 1.0 -2.6 -2.3 -2.4 1.9 -2.7 -3.0 -2.4 2.6 2.1 2.1 -3.0 3.2 1.9 -1.5 -2.7 2.6 0.2
Tense / ‘highly strung’ 3.0 4.9 12.0 1.6 -2.4 -2.7 -2.3 2.0 -1.9 -2.1 -3.5 2.3 2.1 1.8 -2.4 2.1 1.1 -0.0 -2.6 2.5 2.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 9.2 0.7 0.4 -0.3 0.6 -0.3 0.9 0.5 -0.8 -0.6 -0.7 -0.4 0.1 -0.2 -1.4 0.6 -0.0 0.2 3.0
Hair/balding pattern: Pattern 4 0.2 0.4 2.3 1.5 -0.3 0.5 -0.7 0.7 -0.3 -0.2 -0.3 0.6 -0.0 0.9 0.3 -0.3 0.5 -1.0 -0.2 0.9 0.7
Birth weight of first child 1.1 2.0 6.0 -1.1 1.4 1.8 1.1 -1.7 0.6 1.6 2.4 -1.4 -1.1 -1.1 1.8 -1.8 -0.8 -0.6 1.3 -1.8 0.7
Peak expiratory flow (PEF) 0.2 0.5 1.5 1.2 -0.7 -0.1 -0.6 0.9 -0.5 -0.7 -0.9 0.7 0.5 0.3 -0.5 0.4 1.0 -0.8 -0.3 1.0 0.5
Pulse wave reflection index 0.7 0.8 2.0 0.6 -0.9 -0.3 -1.0 1.0 -1.2 -0.8 -0.4 1.1 1.0 1.3 -0.6 0.7 0.8 -0.6 -0.8 1.4 0.7
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.6 -0.3 0.8 0.6 0.8 0.2 1.2 1.0 0.3 -0.7 -0.7 0.1 0.9 -0.9 -0.7 0.6 1.1 -0.4 -0.9
Loud music exposure frequency 0.4 0.5 2.8 -0.0 0.6 0.1 0.7 -0.7 0.4 0.5 0.2 -0.5 -0.2 -0.7 0.0 -0.2 -0.8 1.7 0.1 0.2 1.4
Qualifications: O levels/GCSEs or equivalent 1.2 1.9 4.6 -0.6 1.4 1.3 1.6 -1.2 1.6 1.6 1.6 -1.5 -2.1 -1.1 1.5 -1.0 -1.3 1.0 1.7 -1.4 0.4
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 8.2 0.7 0.3 0.6 0.2 0.4 0.6 0.3 -0.7 -0.1 -0.1 0.6 0.3 -0.5 -0.8 1.3 -0.3 0.6 2.9
Blood clot in the leg (DVT) 1.3 1.7 7.1 -0.4 1.2 1.0 1.2 -0.5 1.1 1.2 1.1 -1.1 -1.1 -0.9 1.1 -1.0 -2.4 1.2 0.9 -0.9 2.7
Medication: Paracetamol 1.5 2.5 5.5 1.3 -1.7 -1.9 -2.0 2.4 -1.7 -1.6 -0.4 2.0 2.0 1.8 -1.1 0.9 1.4 -0.4 -1.8 1.7 -1.0
Headache pain in last month 0.1 0.2 1.0 0.3 0.2 0.1 -0.1 -0.0 -0.2 0.5 0.5 -0.2 -0.3 -0.4 0.8 -0.9 -0.2 0.0 -0.3 -0.7 1.0
Medication for cholesterol, blood pressure or diabetes 1.3 2.2 6.6 -1.2 1.7 2.6 1.7 -1.3 1.8 1.2 1.4 -1.7 -1.6 -0.8 1.5 -1.0 -1.4 0.4 1.9 -0.8 1.2
Glaucoma (self-reported) 7.5 8.9 16.2 0.4 3.4 3.8 3.1 -1.1 3.9 3.6 4.0 -3.1 -2.9 -0.9 3.9 -4.0 -2.1 1.5 3.7 -2.6 -0.7
Gout (self-reported) 0.2 0.2 1.0 -1.0 -0.1 -0.1 -0.4 -0.7 -0.9 -0.3 -0.5 0.2 0.3 -0.3 -0.2 0.6 0.7 0.2 -0.1 -0.0 -0.4
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.9 -0.4 0.5 0.6 0.5 -0.8 0.1 -0.1 1.0 -0.3 0.1 0.1 0.2 0.2 0.3 0.4 0.8 0.2 -0.8
Medication: Amlodipine 1.4 2.0 4.3 1.3 -1.5 -1.3 -1.5 2.1 -0.9 -1.5 -0.9 1.6 1.4 2.1 -1.2 1.0 1.6 -0.4 -1.5 1.5 1.5
Medication: Ventolin 100micrograms inhaler 0.7 0.8 3.1 0.5 -0.9 -0.7 -1.3 1.8 -0.7 -0.6 0.3 1.2 1.4 1.3 0.0 -0.1 1.0 -1.0 -0.9 0.4 0.2
Birth weight 1.7 3.8 10.1 -0.9 2.4 3.2 2.1 -2.0 1.9 2.3 1.9 -2.1 -2.2 -1.4 2.4 -2.1 -1.0 -0.3 2.3 -1.2 0.4
Chronic bronchitis/emphysema (mother) 0.3 0.4 2.3 -0.3 0.7 0.8 0.6 0.1 0.6 0.3 -0.3 -0.3 -0.3 -0.8 0.4 -0.3 -0.7 1.5 0.4 0.4 0.9
High blood pressure (siblings) 1.4 2.1 4.3 1.4 -1.6 -1.8 -1.7 1.2 -2.0 -1.3 -1.0 1.7 1.5 1.1 -1.3 1.2 1.2 -0.7 -2.1 0.8 1.4
Forced vital capacity (FVC), Best measure 0.4 1.3 3.5 0.8 1.2 0.6 1.3 -0.7 1.8 1.4 0.4 -1.3 -1.9 -1.0 1.0 -1.0 -1.6 1.0 1.2 -0.4 0.8
Body fat percentage 0.3 1.2 18.1 -0.9 0.1 -0.2 0.0 -0.4 -0.3 0.1 0.7 -0.1 -0.4 -0.4 0.2 -0.3 0.9 -0.1 0.6 0.2 -4.2
Leg fat percentage (right) 0.3 1.2 15.8 -1.3 -0.2 -0.6 -0.2 -0.3 -0.7 -0.3 0.3 0.2 0.2 -0.2 -0.5 0.3 1.1 -0.9 0.4 0.6 -4.0
Arm fat-free mass (right) 1.3 6.5 10.6 -2.0 3.0 2.9 2.9 -2.4 2.8 3.1 3.3 -2.9 -2.8 -1.9 2.8 -3.0 -2.1 1.4 2.8 -1.7 -0.1
Exposure to tobacco smoke outside home 0.1 0.2 0.8 -0.6 0.3 -0.8 0.1 -0.5 -0.1 0.4 0.1 -0.2 -0.3 -0.0 -0.0 -0.1 -0.2 0.9 -0.6 -0.1 -0.2
Comparative body size at age 10 0.1 0.3 1.1 -0.6 0.6 1.0 0.5 -0.7 0.2 0.5 0.1 -0.5 0.0 -0.2 0.4 -0.4 -0.1 -0.5 0.8 0.3 0.2
Number of full brothers 0.7 0.9 1.9 -1.1 1.3 1.1 1.1 -0.9 1.1 0.9 1.4 -1.1 -0.2 -0.5 1.1 -0.8 -1.1 0.7 0.8 -0.4 -0.0
Worry too long after embarrassment 0.6 1.0 4.8 1.7 -0.7 0.7 -1.0 0.9 -1.2 0.1 0.3 1.0 -0.0 0.8 0.6 -0.6 1.0 -0.5 -1.1 0.4 2.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 3.7 0.1 -0.8 -1.1 -0.8 0.2 -0.9 -0.6 -0.7 0.8 1.1 1.0 -0.9 0.9 -0.6 -0.1 -0.9 1.0 1.9
Wheeze or whistling in the chest in last year 0.5 0.9 4.3 1.4 -0.6 -0.6 -0.8 1.4 -0.4 -0.5 -1.1 0.9 0.3 1.4 -0.3 0.2 1.0 -0.2 -0.2 2.1 0.3
Number of children fathered 3.4 3.8 7.5 -0.8 2.3 2.7 2.3 -0.9 2.6 2.1 2.0 -2.2 -2.4 -0.8 2.4 -2.5 -0.8 0.5 2.4 -1.5 -1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 2.5 0.5 -0.8 -0.4 -0.9 0.9 -0.7 -0.9 -0.6 1.0 1.2 1.1 -1.1 1.1 0.6 -1.6 -0.7 1.5 -0.4
Age at first live birth 0.1 0.1 0.7 -0.1 -0.3 0.0 -0.3 0.0 -0.4 -0.5 -0.4 0.3 0.2 0.1 -0.2 0.4 -0.1 -0.8 0.1 0.1 -0.8
Pulse wave peak to peak time 0.8 0.9 2.9 -0.9 0.8 -0.2 1.3 -1.2 1.4 0.4 -0.7 -1.2 -1.0 -1.3 -0.3 0.2 -1.7 0.8 1.0 -0.4 0.7
Health satisfaction 1.3 1.7 5.4 2.3 -1.4 0.2 -1.4 2.3 -1.0 -0.9 -0.2 1.5 1.5 2.0 -0.4 -0.0 0.5 -2.0 -0.6 1.0 -0.8
Shortness of breath walking on level ground 0.6 0.7 2.3 -0.8 0.8 1.3 0.6 -0.1 0.6 0.9 1.5 -0.6 -0.3 0.1 0.9 -0.9 -0.3 0.3 1.5 -0.2 -1.2
Qualifications: College or University degree 0.3 0.9 4.2 0.9 -0.8 0.7 -0.7 0.9 -0.5 -1.1 -0.8 0.9 0.7 1.9 -0.4 0.8 0.1 -2.1 -0.7 1.2 0.2
Eye problems/disorders: None of the above 6.4 7.4 16.4 -0.1 -3.4 -2.7 -3.4 1.7 -4.1 -3.3 -2.7 3.2 2.8 1.4 -3.0 2.6 2.8 -2.7 -3.1 0.7 -1.8
Mouth/teeth dental problems: Loose teeth 0.3 0.3 1.0 -0.7 0.3 0.8 0.4 -0.3 0.5 0.3 0.8 -0.3 -0.3 0.4 0.6 -0.5 -0.3 -0.0 1.0 -0.0 -0.9
Emphysema/chronic bronchitis 1.3 1.4 3.0 -0.5 1.2 1.5 1.0 -0.4 1.1 1.5 1.0 -1.0 -1.1 -0.4 1.6 -1.7 -1.7 1.1 1.0 -1.7 0.7
Medication for pain relief, constipation, heartburn 1.3 2.2 3.4 -1.6 1.3 1.6 1.5 -1.8 1.4 1.4 1.1 -1.5 -1.6 -1.3 1.3 -1.2 -1.9 0.5 1.7 -1.8 1.6
Neck or shoulder pain in last month 0.2 0.3 0.8 -0.9 -0.3 -0.9 -0.3 0.2 -0.6 -0.4 -0.1 0.4 0.9 0.1 -0.7 0.7 -0.0 0.4 -0.0 0.8 -0.7
Medication: Blood pressure 2.3 4.1 8.3 1.5 -2.3 -2.9 -2.4 2.1 -2.2 -1.8 -2.0 2.3 2.3 1.6 -1.9 1.4 2.5 -0.8 -2.4 1.8 -1.0
Angina (self-reported) 0.9 1.2 3.6 0.9 -1.3 -0.7 -1.5 1.9 -1.4 -0.8 -0.1 1.4 0.7 0.8 -0.4 0.0 1.4 -1.2 -1.9 0.1 0.4
Migraine (self-reported) 0.2 0.2 2.3 -0.3 0.0 -0.0 0.1 -0.6 -0.1 0.1 0.5 -0.2 -0.1 -0.7 -0.2 0.0 -0.4 0.3 0.2 -0.3 -1.5
Medication: Ibuprofen 2.6 3.1 12.9 1.9 -1.2 -2.1 -1.1 1.1 -1.0 -1.9 -3.6 1.3 1.4 0.8 -2.2 2.2 0.9 -0.4 -1.7 2.4 1.4
Medication: Allopurinol 0.1 0.2 0.7 -0.7 0.3 0.2 0.2 -0.9 -0.1 0.1 -0.2 -0.3 -0.1 -0.5 0.0 0.3 -0.4 -0.4 -0.0 -0.5 0.6
Medication: Omeprazole 0.1 0.2 0.8 0.2 0.4 0.5 0.5 0.0 0.4 0.4 0.9 -0.3 -0.3 -0.2 0.4 -0.4 -0.1 -0.7 0.2 0.1 0.1
Medication: Seretide 50 evohaler 1.2 1.3 4.9 -1.1 1.3 2.2 1.3 -1.5 0.8 1.3 0.9 -1.1 -0.9 -0.9 1.1 -1.1 -1.2 0.6 1.1 -0.7 -0.1
Mean time to correctly identify matches 1.2 2.3 5.8 -0.2 -1.5 -1.5 -1.7 1.6 -1.5 -1.6 -1.7 1.7 2.4 1.2 -1.4 1.4 1.6 0.0 -2.1 1.7 -0.1
Heart disease (mother) 0.3 0.4 1.3 1.1 -0.5 -0.0 -0.5 0.8 -0.3 -0.3 -0.4 0.5 0.2 0.6 0.1 -0.1 1.1 -1.1 -0.6 -0.3 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.9 2.2 3.9 1.8 -1.5 -1.2 -1.3 1.3 -1.4 -2.0 -2.0 1.6 1.5 1.1 -1.7 1.8 1.2 -1.1 -1.5 1.6 0.3
Whole body fat mass 0.4 1.6 13.6 -1.3 0.9 0.7 0.8 -1.0 0.6 0.9 1.4 -0.9 -1.1 -0.8 0.9 -1.0 0.4 0.2 1.4 -0.3 -3.7
Leg fat mass (right) 0.4 1.5 11.2 -1.7 1.0 0.5 1.0 -1.2 0.6 1.0 1.4 -1.0 -1.1 -1.0 0.8 -0.9 0.2 -0.1 1.4 -0.2 -3.4
Arm predicted mass (right) 1.0 5.2 10.4 -1.9 2.6 2.7 2.5 -2.2 2.4 2.8 3.2 -2.5 -2.5 -1.7 2.6 -2.8 -1.5 0.8 2.4 -1.6 0.2
Pulse rate, automated reading 0.3 1.0 2.2 0.6 -0.8 -0.9 -0.7 0.8 -0.5 -1.1 -0.5 0.8 1.2 1.2 -1.2 1.2 1.2 0.1 0.5 1.5 -1.5
Alcohol intake frequency. 1.2 2.8 6.8 1.4 -1.9 -2.6 -1.9 1.8 -1.6 -1.9 -2.6 1.8 1.2 0.6 -1.9 1.5 0.5 0.6 -2.0 1.0 1.2
Comparative height size at age 10 2.0 10.8 15.8 -3.8 3.8 2.8 3.7 -3.9 3.4 3.7 3.1 -3.8 -3.4 -3.0 2.9 -2.5 -3.0 2.5 4.0 -2.3 2.6
Number of full sisters 0.3 0.3 1.1 0.5 0.2 -0.6 -0.0 0.3 0.2 0.8 1.1 -0.0 0.4 1.0 0.7 -1.1 -0.0 0.5 -0.4 0.3 -0.1
Suffer from ‘nerves’ 0.4 0.7 3.2 0.8 -0.7 -0.2 -0.5 0.9 -0.3 -0.6 -1.8 0.6 0.4 0.5 -0.5 0.2 -1.4 -0.1 -0.5 0.4 1.8
Overall health rating 0.4 0.8 4.0 2.0 -0.2 0.7 -0.7 1.7 -0.4 0.1 0.4 0.7 0.2 1.7 0.7 -1.0 -0.1 -0.2 -0.5 0.7 0.6
Chest pain or discomfort 1.0 1.5 2.6 1.4 -1.5 -1.2 -1.4 1.2 -1.5 -1.3 -1.1 1.4 1.1 1.6 -1.3 1.1 0.8 -1.0 -1.2 0.5 -0.3
Had major operations 0.3 0.3 1.0 0.5 -0.5 -0.6 -0.4 0.6 -0.1 -0.3 -0.8 0.5 0.6 0.9 -0.4 0.3 0.9 -0.1 -0.5 1.0 -0.5
Age at last live birth 0.7 1.0 2.5 0.5 -1.0 -1.6 -1.1 0.8 -1.0 -1.0 -0.9 1.1 1.1 0.8 -1.0 1.1 0.8 -1.1 -1.0 1.6 -0.4
Family relationship satisfaction 6.8 8.3 17.0 3.9 -3.1 -2.5 -3.2 4.1 -2.2 -2.8 -2.9 3.3 3.5 3.6 -2.4 1.9 0.8 -1.3 -2.7 2.5 3.2
Leg pain on walking 0.3 0.3 1.8 -0.1 0.7 0.2 0.8 -0.5 0.8 0.6 0.4 -0.8 -0.4 -0.3 0.3 -0.5 -1.3 0.2 0.6 -0.5 -0.0
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 2.9 -1.7 0.3 -0.6 0.5 -1.2 -0.1 0.1 -0.5 -0.4 0.2 -1.5 -0.8 0.6 0.6 1.4 0.5 -0.1 -0.6
Commuting to job workplace: Car/motor vehicle 0.7 0.8 3.1 1.4 0.0 0.4 -0.5 1.6 0.0 0.4 0.3 0.2 0.2 0.7 1.4 -1.5 0.0 -0.6 -0.2 -0.3 -1.8
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 1.0 -0.0 -0.7 -0.5 -0.7 0.3 -0.8 -0.8 -0.3 0.7 0.6 0.5 -0.6 0.8 -0.1 -1.0 -0.5 0.1 0.2
Medication: Aspirin 0.1 0.1 0.4 0.3 0.3 0.1 0.4 0.4 0.6 -0.2 -0.2 -0.2 -0.1 0.2 -0.1 0.1 0.1 -0.1 0.1 0.2 -0.7
Supplements: Vitamin C 1.0 1.2 3.5 -1.9 0.7 0.2 0.4 -0.7 0.1 0.9 1.7 -0.6 0.3 -1.3 0.8 -0.7 -1.5 1.5 0.8 -1.4 -1.5
Knee pain experienced in last month 1.1 1.6 3.1 -0.1 1.4 1.5 1.4 -0.6 1.4 1.4 1.0 -1.3 -1.6 -1.0 1.2 -1.6 -1.8 1.2 1.4 -1.5 -0.1
Hypertension (Self-reported) 2.2 6.1 10.7 1.4 -2.9 -3.3 -3.1 2.8 -2.9 -2.3 -2.4 3.0 2.8 2.5 -2.2 1.8 2.3 -0.4 -3.0 2.5 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 2.1 0.2 0.4 0.3 0.5 -0.3 0.3 0.6 0.6 -0.5 -0.6 -0.5 0.4 -0.4 -1.4 0.4 0.4 -1.2 0.8
Illnesses of father: Heart disease 0.4 0.6 2.1 0.3 -1.0 -0.7 -1.0 0.7 -1.1 -0.0 -0.2 0.8 0.2 0.1 0.1 -0.4 1.5 -0.9 -1.0 -1.0 -0.3
Illnesses of siblings: Diabetes 0.3 0.4 1.1 -0.6 -0.0 0.3 -0.6 0.5 -0.6 -0.1 0.5 0.5 1.1 0.9 0.1 -0.2 0.9 -0.3 -0.6 0.9 -0.7
Smoking status: Previous 0.3 0.5 5.6 -1.0 0.4 0.2 0.1 -0.5 0.0 0.4 0.6 -0.2 -0.4 -0.1 0.3 -0.3 0.4 0.8 0.5 -0.1 -2.4
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 2.0 -0.5 -0.7 -1.4 -0.6 -0.4 -0.9 -0.4 -0.3 0.4 0.1 -0.3 -1.0 0.9 -0.1 -0.2 -1.2 0.3 0.6
Whole body fat-free mass 0.8 4.8 7.6 -1.5 2.5 2.7 2.5 -1.9 2.4 2.7 2.8 -2.4 -2.5 -1.6 2.4 -2.7 -1.6 0.7 2.4 -1.4 0.6
Leg fat-free mass (right) 1.3 6.7 10.5 -1.5 3.0 3.1 2.9 -2.3 2.9 3.2 3.1 -2.9 -3.2 -2.0 3.0 -3.2 -1.8 1.3 2.8 -1.8 0.4
Arm fat percentage (left) 0.3 1.0 13.8 -0.4 0.3 0.3 0.1 -0.1 -0.1 0.4 1.0 -0.2 -0.5 -0.4 0.6 -0.8 0.9 -0.4 0.6 -0.1 -3.7
Average weekly red wine intake 0.7 1.0 2.3 -0.5 1.2 1.4 1.5 -1.4 1.4 1.1 0.5 -1.3 -0.9 -0.6 0.7 -0.5 -0.9 0.5 1.5 -0.2 -0.0
Handedness (chirality/laterality): Left-handed 0.2 0.2 1.2 -0.1 0.4 0.1 0.6 -0.4 0.5 -0.1 -1.0 -0.4 -0.1 -0.3 -0.3 0.2 -0.4 0.7 -0.2 0.4 1.1
Mood swings 0.6 1.1 4.8 2.0 -0.4 -0.0 -0.7 1.6 -0.1 -0.2 -0.9 0.7 0.9 1.3 0.1 -0.4 -1.3 0.6 -0.6 1.4 2.2
Loneliness, isolation 0.5 0.7 4.8 0.8 -0.1 -0.8 -0.6 0.8 -0.5 0.7 -0.6 0.4 0.5 0.5 0.6 -1.2 -0.2 0.3 -0.9 -0.5 2.2
Long-standing illness, disability or infirmity 1.8 2.8 9.2 3.0 -1.6 -1.0 -1.9 3.0 -1.2 -1.0 -0.5 1.9 1.5 2.9 -0.5 -0.1 1.5 -0.5 -1.9 1.4 -0.3
Ever had bowel cancer screening 1.5 1.7 4.0 0.6 1.4 1.7 1.3 -0.6 1.5 1.6 1.0 -1.3 -1.8 -0.7 1.8 -2.0 -0.7 1.1 1.7 -0.7 -0.4
Diabetes diagnosed by doctor 0.4 0.7 2.7 -0.0 1.0 1.3 1.0 0.7 1.6 0.8 1.2 -0.7 -0.1 0.0 0.9 -0.9 -0.3 0.4 1.0 0.1 0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 1.7 -0.2 -0.3 -1.0 -0.3 -0.3 -0.5 -0.5 -1.3 0.2 0.7 -0.3 -0.8 0.9 0.1 0.4 -0.6 0.3 -0.1
Friendships satisfaction 1.6 2.0 6.6 1.5 -1.1 -1.4 -1.0 1.5 -0.4 -1.2 -2.1 1.2 1.3 1.3 -1.5 1.4 0.1 -0.1 -1.0 2.6 2.2
Qualifications: nursing, teaching 0.8 1.3 3.4 0.3 1.1 1.9 1.3 0.0 1.8 0.9 1.3 -1.1 -1.1 -0.3 1.4 -1.3 -0.3 0.1 1.4 -1.1 -0.8
Commuting to job workplace: Walk 0.4 0.5 1.5 -0.8 0.5 0.4 0.6 -0.8 0.5 0.9 1.0 -0.6 -1.2 -0.6 0.3 -0.4 -0.6 0.2 0.9 -0.7 -0.0
Eye problems/disorders: Cataract 0.7 0.8 4.9 0.1 0.8 0.4 0.8 -0.3 1.1 0.9 0.7 -0.7 -0.9 -0.3 0.6 -0.5 -1.3 1.2 0.2 -0.1 2.2
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 2.5 0.1 -0.3 -1.0 -0.4 0.1 -0.2 -0.4 -1.6 0.4 -0.2 0.6 -0.6 0.6 -0.3 1.5 -1.0 1.6 1.2
Medication for cholesterol 0.4 0.6 1.5 0.3 0.7 0.1 1.0 -1.2 1.1 0.5 -0.6 -1.1 -1.2 -0.9 -0.2 0.2 -0.9 0.2 1.2 -0.6 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.3 -1.0 0.7 0.4 0.6 -1.1 0.1 0.6 0.2 -0.7 -0.9 -0.9 0.5 -0.3 0.2 -0.0 0.7 -0.1 -0.7
Back pain experienced in last month 0.4 0.6 1.1 0.8 -0.8 -0.1 -0.8 0.8 -1.0 -0.9 -0.7 1.0 0.7 0.8 -0.8 0.8 0.2 -0.8 -0.7 1.1 -0.4
Mineral and other dietary supplements 0.2 0.3 1.9 0.4 -0.2 0.0 -0.1 0.3 0.1 -0.3 -0.7 0.2 -0.3 0.2 -0.6 0.5 0.6 -1.4 -0.4 0.8 0.8
Breast cancer (self-reported) 2.7 3.3 5.2 -1.2 2.0 2.0 2.0 -1.0 2.3 1.7 2.1 -2.0 -1.9 -1.8 1.8 -1.8 -2.0 0.9 1.6 -2.2 1.4
Asthma (self-reported) 1.9 3.8 6.9 1.9 -2.1 -1.0 -2.5 2.4 -2.4 -1.6 -0.6 2.4 2.3 2.5 -1.1 0.8 2.6 -2.0 -2.3 1.9 -0.7
Osteoporosis (self-reported) 0.2 0.3 0.8 -0.3 -0.8 -0.9 -0.7 0.3 -0.8 -0.4 -0.0 0.6 0.6 -0.1 -0.7 0.7 0.6 -0.0 -0.5 -0.3 -0.3
Osteoarthritis (self-reported) 2.2 2.8 5.7 -0.7 1.9 1.9 1.5 -1.6 1.1 2.2 2.4 -1.6 -1.5 -1.0 1.8 -1.9 -1.7 1.5 1.3 -0.9 2.3
Medication: Aspirin 0.1 0.1 0.5 0.6 0.2 -0.0 0.3 0.7 0.6 -0.2 -0.3 -0.1 -0.1 0.4 -0.1 0.1 -0.2 -0.1 -0.0 0.4 -0.6
Medication: Gliclazide 0.7 0.7 3.8 1.4 -0.5 -0.5 -0.5 1.3 -0.0 -0.3 -0.1 0.6 0.6 1.2 -0.3 0.1 0.5 0.2 -0.7 1.4 1.9
Illnesses of father: None of the above (group 1) 1.1 1.4 4.5 -1.4 1.2 0.2 1.4 -1.2 1.3 0.7 0.0 -1.3 -0.5 -1.2 0.3 -0.3 -2.1 2.1 1.2 -0.6 -1.0
Smoking status: Current 0.9 1.4 6.1 0.7 1.1 1.3 0.9 0.6 1.6 1.4 0.1 -0.8 -0.5 0.1 1.6 -2.0 -1.4 1.0 0.8 -0.1 2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 2.1 1.4 -0.9 -0.3 -1.1 0.9 -1.0 -1.2 -1.1 1.1 1.3 0.6 -0.6 0.7 0.7 -0.1 -1.2 1.4 -0.4
Whole body water mass 0.9 4.9 8.1 -1.6 2.5 2.8 2.5 -1.9 2.4 2.8 2.9 -2.5 -2.6 -1.6 2.5 -2.8 -1.6 0.6 2.4 -1.4 0.5
Leg predicted mass (right) 1.2 6.5 10.2 -1.5 2.9 3.1 2.9 -2.2 2.9 3.2 3.0 -2.9 -3.2 -2.0 2.9 -3.1 -1.8 1.3 2.8 -1.8 0.4
Arm fat mass (left) 0.3 1.1 9.5 -0.7 0.7 0.8 0.6 -0.4 0.4 0.9 1.6 -0.6 -0.9 -0.4 1.1 -1.3 0.5 -0.4 0.9 -0.2 -3.1
Number of self-reported non-cancer illnesses 0.7 1.2 2.8 0.9 -1.4 -0.5 -1.6 1.2 -1.7 -0.6 -0.3 1.6 1.4 1.4 -0.6 0.4 1.4 -0.3 -1.2 1.2 0.2
Average weekly champagne plus white wine intake 1.2 1.7 3.2 1.0 1.5 1.2 1.3 -1.2 1.6 1.5 0.7 -1.5 -1.5 -1.0 1.6 -1.8 -1.3 -0.6 0.8 -1.6 0.8
Miserableness 0.4 0.8 5.4 1.7 -0.3 -0.7 -0.6 1.2 -0.1 0.1 -1.1 0.4 -0.2 0.8 0.2 -0.6 -0.0 0.7 -0.6 0.2 2.3
Guilty feelings 0.7 1.0 2.7 1.1 -0.9 -0.5 -1.2 1.5 -0.9 -0.6 -0.7 1.2 1.6 1.3 -0.4 0.1 0.7 -0.4 -0.9 1.6 0.6
Wears glasses or contact lenses 0.8 0.9 3.5 -1.9 0.5 0.4 0.5 -1.2 -0.1 0.7 1.9 -0.5 -0.3 -1.1 0.5 -0.4 -0.2 0.8 0.9 -1.3 -0.9
Ever taken oral contraceptive pill 3.2 3.6 5.5 1.3 -2.2 -1.6 -2.1 2.3 -1.8 -2.3 -2.0 2.2 2.3 1.8 -1.7 1.5 1.4 -1.6 -2.2 1.1 -1.9
Hearing aid user 1.0 1.1 1.9 -1.2 1.0 0.7 0.9 -1.1 0.8 1.3 1.2 -1.1 -0.9 -1.4 1.1 -1.0 -1.1 0.5 1.1 -1.2 -0.7
Mother’s age at death 0.7 0.9 3.1 0.2 -0.8 -0.6 -0.8 0.5 -0.7 -0.8 -1.2 0.8 0.9 0.8 -0.9 0.8 1.6 0.5 -0.3 1.6 -1.8
Financial situation satisfaction 5.2 6.5 9.6 2.3 -2.8 -2.9 -3.0 3.1 -2.9 -2.5 -2.0 3.1 3.1 2.8 -2.5 2.0 1.8 -0.8 -2.9 2.9 -0.0
Tinnitus: Yes, now most or all of the time 1.7 2.0 6.1 -1.7 1.1 1.3 0.7 -1.3 0.4 1.7 2.5 -1.0 -1.3 -1.0 1.9 -1.9 -0.8 0.5 1.2 -2.2 -0.5
Commuting to job workplace: Public transport 0.5 0.6 5.7 0.7 0.4 -0.3 0.6 -0.5 0.6 0.3 0.2 -0.5 -0.6 -0.6 0.0 0.1 -0.6 1.2 -0.1 -0.3 2.4
Eye problems/disorders: Glaucoma 3.9 4.6 13.0 0.7 2.4 2.5 2.2 -0.7 2.8 2.7 3.6 -2.1 -1.6 -0.2 2.8 -2.9 -0.8 1.1 3.1 -1.2 -0.6
Medication: Blood pressure 0.8 1.6 4.0 -0.7 -1.5 -1.3 -1.6 1.1 -2.0 -1.0 -0.5 1.6 1.5 1.2 -0.8 0.7 1.2 -0.2 -2.0 0.9 0.8
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.4 -0.1 0.6 0.3 0.4 0.4 0.7 1.0 0.4 -0.4 -0.1 -0.3 0.8 -1.1 0.1 1.2 0.5 -0.4 -1.2
Supplements: Fish oil (including cod liver oil) 0.3 0.3 1.7 -0.2 0.3 0.1 0.0 0.1 -0.0 0.4 0.6 -0.2 -0.1 -0.4 0.8 -0.9 -0.4 1.2 0.5 -1.3 -0.4
High cholesterol (Self-reported) 0.1 0.2 0.8 0.9 -0.1 -0.2 -0.2 0.1 -0.4 0.2 0.0 0.3 -0.2 -0.1 -0.0 0.1 0.1 0.9 0.3 0.5 -0.9
Medication: Bendroflumethiazide 2.3 3.5 6.9 1.1 -2.3 -1.8 -2.5 2.0 -2.6 -2.0 -0.9 2.3 2.1 1.4 -1.5 1.2 2.2 -2.1 -2.6 0.6 -0.3
Medication: Paracetamol 1.7 2.7 4.9 0.8 -1.8 -2.2 -2.0 2.0 -2.0 -1.8 -1.1 2.0 1.9 1.4 -1.5 1.3 1.4 -0.7 -1.9 1.5 -1.2
Medication: Lisinopril 1.7 2.2 4.4 -0.9 -1.7 -2.1 -1.6 0.4 -1.9 -1.6 -0.6 1.5 2.1 0.3 -1.8 1.9 1.0 -1.6 -1.9 1.0 -0.7
Medication: Atorvastatin 1.7 2.1 7.8 1.8 -1.4 -1.0 -1.7 2.0 -1.6 -0.9 -0.2 1.6 0.9 1.7 -0.4 0.0 2.8 -1.0 -1.8 0.3 -1.7
Illnesses of father: High blood pressure 0.7 0.8 5.2 0.5 -0.8 0.4 -1.0 0.6 -1.2 -0.6 0.5 0.9 0.7 0.7 -0.3 0.2 0.3 -2.3 -1.0 0.5 1.2
Alcohol drinker status: Never 0.6 0.7 4.2 -0.7 0.2 -1.0 -0.0 -0.3 0.0 0.2 -0.1 -0.2 -0.1 -1.2 0.1 -0.3 -1.3 2.1 -0.5 -1.0 1.6
Ever smoked 0.3 0.4 1.1 -0.5 1.0 0.5 0.7 -0.5 0.9 0.9 -0.4 -0.6 -0.4 0.5 0.6 -0.7 -0.3 0.5 0.3 1.1 -1.0
Basal metabolic rate 0.7 4.2 7.5 -1.5 2.3 2.5 2.3 -1.8 2.2 2.6 2.7 -2.3 -2.5 -1.4 2.3 -2.6 -1.2 0.5 2.3 -1.2 -0.1
Leg fat percentage (left) 0.4 1.6 15.9 -2.2 0.7 0.1 0.7 -1.3 0.0 0.5 1.1 -0.7 -0.6 -1.2 0.3 -0.3 0.3 -0.2 1.1 -0.2 -4.0
Arm fat-free mass (left) 0.6 3.0 7.3 -1.7 1.9 2.1 1.8 -1.5 1.7 2.1 2.7 -1.8 -1.8 -1.0 1.9 -2.2 -1.0 0.2 1.9 -1.1 -0.4
Number of operations (self-reported) 0.2 0.3 1.7 0.6 -0.0 0.0 -0.0 0.6 0.2 0.0 0.0 0.1 0.1 1.2 0.2 -0.2 0.9 -1.3 -0.2 1.1 0.2
Average weekly beer plus cider intake 0.4 0.5 1.5 -0.3 -0.4 -1.0 -0.7 0.4 -1.0 0.1 0.9 0.4 0.2 0.7 0.4 -0.6 1.0 -0.9 -1.2 -0.5 1.1
Irritability 0.5 0.8 3.6 -0.3 -0.6 -0.9 -0.5 -0.0 -0.8 -0.9 -1.9 0.6 1.1 -0.2 -1.2 1.2 -0.4 -0.1 -0.7 1.5 0.7
Risk taking 0.2 0.2 0.6 -0.4 -0.3 -0.6 -0.6 0.2 -0.5 -0.1 0.1 0.4 0.6 0.7 -0.0 -0.0 0.7 -0.7 -0.7 0.4 0.6
Ever had prostate specific antigen (PSA) test 2.0 2.3 4.3 -0.6 1.6 2.1 1.4 -1.3 1.2 1.7 1.6 -1.5 -1.4 -1.8 1.8 -1.9 -1.2 0.6 2.0 -1.8 0.0
Fractured/broken bones in last 5 years 0.1 0.1 0.5 0.3 -0.7 -0.2 -0.4 0.4 -0.4 -0.1 0.1 0.5 -0.3 0.2 -0.3 0.1 0.6 -0.3 -0.4 -0.1 0.2
Age started oral contraceptive pill 0.5 0.6 6.2 -0.6 -0.6 -0.3 -0.7 0.7 -0.5 -0.6 0.5 0.6 0.4 0.8 -0.1 0.3 0.9 -0.2 0.1 -0.0 -2.5
Diastolic blood pressure, automated reading 0.0 0.1 0.5 0.1 0.0 -0.5 -0.1 -0.1 -0.0 0.3 0.6 -0.1 -0.2 0.7 0.3 -0.1 0.6 0.4 0.2 0.5 -0.2
Ever depressed for a whole week 1.9 2.3 6.4 -2.1 1.6 1.4 1.4 -1.5 1.0 1.4 1.2 -1.5 -0.8 -1.6 1.4 -1.4 -1.7 0.8 1.0 -1.9 2.5
Unable to work because of sickness or disability 0.1 0.1 0.9 0.9 0.2 -0.4 -0.0 0.6 0.0 0.3 -0.3 0.0 0.4 0.1 0.3 -0.5 -0.2 0.3 -0.1 0.2 0.2
Commuting to job workplace: Cycle 0.5 0.6 2.6 0.6 -0.8 -0.5 -0.5 0.0 -0.7 -0.7 -1.0 0.5 -0.0 0.2 -0.8 0.8 1.6 -1.4 -1.1 0.3 0.3
Myopia 0.2 0.3 0.9 1.0 -0.4 -0.6 -0.2 0.7 0.2 -0.7 -0.9 0.3 0.0 0.4 -0.8 0.7 -0.1 0.1 -0.3 0.7 -0.0
Vascular/heart problems diagnosed by doctor 3.0 8.2 13.5 -1.6 3.4 3.7 3.6 -3.3 3.4 2.6 2.6 -3.5 -3.0 -2.8 2.5 -2.0 -3.0 0.6 3.7 -2.6 -0.3
Cholesterol lowering medication 0.3 0.4 2.2 0.7 0.0 0.7 -0.4 0.9 -0.2 0.3 1.5 0.3 -0.1 0.5 1.1 -0.9 0.9 -0.4 -0.2 -0.2 0.4
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.3 0.0 0.8 0.3 0.9 -0.4 0.8 0.9 1.1 -0.8 -0.9 -0.6 0.8 -0.8 -0.3 -0.2 0.5 -0.7 -0.2
Pain experienced in last month 0.1 0.2 0.8 -0.0 -0.4 -0.3 -0.3 0.3 -0.1 -0.7 -0.2 0.4 0.2 0.6 -0.6 0.7 0.9 -0.2 -0.2 0.6 -0.1
Supplements: Calcium 1.0 1.1 4.7 -1.9 0.5 0.1 0.9 -1.3 0.7 0.5 0.6 -0.9 -1.1 -1.4 0.4 -0.2 -1.0 0.6 0.4 -1.4 -2.2
Basal cell carcinoma (self-reported) 0.9 1.1 2.0 1.4 -1.0 -1.4 -1.4 1.2 -0.9 -0.7 -0.4 1.1 1.0 1.2 -0.7 0.3 0.3 -0.4 -1.3 1.4 1.2
Heart attack/myocardial infarction (self-reported) 0.7 0.9 2.5 1.4 -0.8 -0.6 -1.1 1.3 -0.9 -1.0 -1.1 1.1 0.6 0.9 -0.3 0.6 0.5 -0.5 -1.6 1.2 0.8
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 5.5 -0.2 1.1 1.0 1.1 -0.4 1.1 1.0 0.9 -1.0 -1.0 -0.8 1.1 -1.0 -2.3 1.1 0.9 -0.8 2.2
Heart disease (siblings) 0.2 0.3 1.3 0.0 -0.2 -0.6 -0.4 0.3 -0.4 0.4 0.8 0.2 -0.5 -0.2 0.4 -0.6 -0.0 -0.2 -0.7 -0.9 1.1
Alcohol drinker status: Previous 0.3 0.4 1.8 0.8 -0.7 -1.0 -0.7 0.4 -0.5 -0.5 -1.3 0.6 0.5 -0.2 -0.5 0.4 0.7 0.3 -0.5 0.5 -0.0
Pack years of smoking 0.3 0.4 0.8 -0.7 0.5 0.2 0.6 -0.8 0.4 0.1 -0.4 -0.6 -0.8 -0.7 0.4 -0.0 -0.7 0.7 0.8 -0.9 -0.9
Impedance of whole body 0.5 2.7 5.4 0.7 -1.9 -2.3 -1.9 1.4 -1.8 -2.1 -2.2 1.9 1.8 1.1 -2.0 2.2 0.8 -0.2 -1.8 1.2 -0.2
Leg fat mass (left) 0.6 2.4 10.9 -2.1 1.4 0.9 1.4 -1.7 1.0 1.4 1.8 -1.4 -1.5 -1.5 1.2 -1.3 -0.3 0.3 1.8 -0.7 -3.3
Arm predicted mass (left) 0.5 2.3 5.9 -1.5 1.7 1.9 1.7 -1.4 1.5 1.8 2.4 -1.6 -1.7 -0.7 1.7 -1.9 -0.8 -0.2 1.6 -0.8 -0.4