[Hub]/) : Traits : Irritable Bowel Disease (IBD) : ← →

chr9:138,126,646-140,332,478

Best TWAS P=6.33e-35 · Best GWAS P=3.55e-36 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	INPP5E	0.18	0.14	enet	21	0.21	1.6e-24	8.52	-9.2	2.7e-20	-0.67	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SNAPC4	0.06	0.04	lasso	2	0.05	9.0e-07	11.41	-10.2	1.3e-24	-0.87	0.81	0.16	FALSE
3	GTEx	Adipose Subcutaneous	SDCCAG3	0.13	0.00	enet	21	0.04	4.8e-04	7.14	-6.7	1.7e-11	-0.39	0.20	0.07	FALSE
4	GTEx	Adrenal Gland	INPP5E	0.18	0.02	enet	23	0.10	2.2e-04	8.60	-8.3	9.2e-17	-0.63	0.15	0.35	FALSE
5	GTEx	Artery Tibial	SDCCAG3	0.05	0.00	lasso	4	0.00	2.2e-01	-9.66	-10.7	1.5e-26	-0.75	0.03	0.92	FALSE
6	GTEx	Brain Caudate basal ganglia	INPP5E	0.23	0.20	enet	8	0.22	7.2e-07	8.76	-9.4	3.9e-21	-0.73	0.40	0.36	FALSE
7	GTEx	Brain Cerebellar Hemisphere	INPP5E	0.25	0.23	enet	6	0.17	3.4e-05	8.88	-9.8	8.9e-23	-0.76	0.29	0.58	FALSE
8	GTEx	Brain Cerebellar Hemisphere	GPSM1	0.26	0.07	lasso	4	0.11	9.6e-04	3.53	-6.6	4.5e-11	-0.53	0.08	0.44	FALSE
9	GTEx	Brain Cerebellum	INPP5E	0.40	0.30	enet	20	0.29	3.6e-09	8.76	-9.4	7.7e-21	-0.72	0.86	0.13	FALSE
10	GTEx	Brain Putamen basal ganglia	INPP5E	0.28	0.20	enet	6	0.01	2.2e-01	8.90	-10.0	2.0e-23	-0.80	0.12	0.65	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	INPP5E	0.27	0.05	enet	21	0.14	2.0e-05	8.88	-8.7	3.3e-18	-0.50	0.10	0.40	FALSE
12	GTEx	Cells Transformed fibroblasts	UBAC1	0.22	0.00	enet	9	0.00	8.5e-01	-9.66	5.6	1.8e-08	0.39	0.05	0.08	FALSE
13	GTEx	Cells Transformed fibroblasts	SDCCAG3	0.12	0.03	enet	21	0.06	5.4e-05	7.14	-8.3	1.1e-16	-0.72	0.77	0.22	FALSE
14	GTEx	Cells Transformed fibroblasts	CARD9	0.10	0.01	enet	15	0.02	8.0e-03	-7.34	-10.7	1.4e-26	-0.55	0.06	0.84	FALSE
15	GTEx	Colon Sigmoid	INPP5E	0.22	0.10	lasso	3	0.01	1.6e-01	11.26	-11.6	7.2e-31	-0.95	0.02	0.96	FALSE
16	GTEx	Colon Transverse	SEC16A	0.13	0.04	lasso	4	0.05	2.5e-03	8.22	-6.8	1.0e-11	-0.49	0.14	0.18	FALSE
17	GTEx	Colon Transverse	SDCCAG3	0.11	0.01	lasso	8	0.02	5.5e-02	7.14	-7.5	8.6e-14	-0.58	0.18	0.28	FALSE
18	GTEx	Esophagus Gastroesophageal Junction	SEC16A	0.14	0.00	enet	12	0.02	5.1e-02	3.02	-5.8	4.8e-09	-0.38	0.14	0.07	FALSE
19	GTEx	Esophagus Mucosa	INPP5E	0.11	0.12	lasso	3	0.12	1.0e-08	8.88	-9.2	5.1e-20	-0.65	0.96	0.04	FALSE
20	GTEx	Esophagus Muscularis	SDCCAG3	0.10	0.02	enet	5	0.02	3.6e-02	5.49	-7.7	1.4e-14	-0.46	0.21	0.23	FALSE
21	GTEx	Heart Atrial Appendage	INPP5E	0.13	0.12	lasso	2	0.10	3.5e-05	8.14	-8.2	3.5e-16	-0.61	0.24	0.27	FALSE
22	GTEx	Liver	PMPCA	0.31	0.00	lasso	5	0.06	8.9e-03	1.42	6.4	1.3e-10	0.63	0.03	0.67	FALSE
23	GTEx	Lung	INPP5E	0.10	0.05	enet	13	0.04	6.1e-04	8.76	-9.2	2.7e-20	-0.72	0.59	0.23	FALSE
24	GTEx	Lung	SEC16A	0.14	0.11	enet	23	0.10	2.5e-08	2.91	-5.3	9.1e-08	-0.43	1.00	0.00	FALSE
25	GTEx	Lung	CARD9	0.08	0.04	enet	6	0.04	2.5e-04	7.86	10.2	2.9e-24	0.87	0.02	0.98	FALSE
26	GTEx	Muscle Skeletal	CARD9	0.16	0.12	enet	28	0.11	9.0e-11	-7.34	-8.9	4.6e-19	-0.27	1.00	0.00	TRUE
27	GTEx	Nerve Tibial	INPP5E	0.13	0.17	enet	10	0.14	3.7e-10	9.14	-9.1	6.1e-20	-0.66	1.00	0.00	FALSE
28	GTEx	Ovary	INPP5E	0.24	0.13	enet	11	0.15	1.9e-04	10.15	-10.5	5.7e-26	-0.80	0.08	0.52	FALSE
29	GTEx	Ovary	SEC16A	0.33	0.06	enet	10	0.14	3.4e-04	8.90	-7.5	5.0e-14	-0.65	0.04	0.46	FALSE
30	GTEx	Pancreas	SEC16A	0.28	0.10	enet	16	0.16	4.1e-07	8.22	-9.4	4.5e-21	-0.51	0.52	0.43	FALSE
31	GTEx	Pancreas	SDCCAG3	0.21	0.03	lasso	4	0.01	9.5e-02	6.08	-5.9	3.9e-09	-0.55	0.10	0.05	FALSE
32	GTEx	Pituitary	INPP5E	0.21	0.24	lasso	3	0.14	1.8e-04	8.76	8.2	1.8e-16	0.60	0.14	0.52	FALSE
33	GTEx	Pituitary	SEC16A	0.37	0.07	lasso	8	0.11	9.1e-04	1.44	-5.6	1.8e-08	-0.38	0.13	0.08	FALSE
34	GTEx	Prostate	LCN10	0.30	-0.01	enet	11	0.05	2.4e-02	-0.88	5.2	1.8e-07	0.55	0.03	0.29	FALSE
35	GTEx	Skin Sun Exposed Lower leg	INPP5E	0.10	0.10	lasso	2	0.09	5.2e-08	8.88	-9.3	1.0e-20	-0.73	0.93	0.07	FALSE
36	GTEx	Skin Sun Exposed Lower leg	RP11-611D20.2	0.21	0.16	enet	16	0.17	3.3e-14	2.46	6.3	2.5e-10	0.16	1.00	0.00	TRUE
37	GTEx	Spleen	PMPCA	0.24	0.15	lasso	2	0.10	1.7e-03	8.59	8.0	1.5e-15	0.65	0.03	0.61	FALSE
38	GTEx	Stomach	INPP5E	0.13	0.00	enet	27	0.00	2.0e-01	9.25	-6.9	7.1e-12	-0.43	0.05	0.26	FALSE
39	GTEx	Stomach	SEC16A	0.15	0.09	lasso	4	0.10	1.8e-05	8.26	-8.8	1.7e-18	-0.60	0.62	0.28	FALSE
40	GTEx	Testis	INPP5E	0.24	0.32	enet	10	0.30	5.4e-14	9.14	-9.3	1.2e-20	-0.70	1.00	0.00	FALSE
41	GTEx	Testis	SDCCAG3	0.15	0.09	lasso	4	0.13	3.3e-06	7.14	-9.1	1.0e-19	-0.66	0.48	0.38	FALSE
42	GTEx	Thyroid	INPP5E	0.23	0.35	enet	16	0.37	8.2e-30	9.25	-10.3	1.1e-24	-0.81	0.91	0.09	FALSE
43	GTEx	Thyroid	PMPCA	0.10	0.05	enet	11	0.10	8.7e-08	8.42	-9.4	4.2e-21	-0.57	0.33	0.65	FALSE
44	GTEx	Thyroid	SDCCAG3	0.16	0.11	lasso	3	0.12	9.4e-10	7.14	-7.0	2.3e-12	-0.61	1.00	0.00	FALSE
45	GTEx	Uterus	INPP5E	0.60	0.04	enet	10	0.22	3.4e-05	10.10	-10.1	4.5e-24	-0.73	0.06	0.48	FALSE
46	GTEx	Whole Blood	SEC16A	0.07	0.05	lasso	5	0.04	1.3e-04	8.22	-8.5	1.4e-17	-0.63	0.68	0.28	FALSE
47	GTEx	Whole Blood	SDCCAG3	0.07	0.03	enet	6	0.02	3.4e-03	8.40	-10.6	5.1e-26	-0.84	0.02	0.98	FALSE
48	GTEx	Whole Blood	CARD9	0.08	0.07	lasso	1	0.05	4.2e-05	12.21	12.2	2.9e-34	0.99	0.02	0.98	FALSE
49	METSIM	Adipose	CARD9	0.04	0.05	enet	6	0.06	5.9e-09	-9.66	11.4	5.9e-30	0.78	0.15	0.85	FALSE
50	METSIM	Adipose	QSOX2	0.06	0.00	bslmm	370	0.02	1.8e-03	1.23	5.8	8.0e-09	0.29	0.10	0.36	FALSE
51	NTR	Blood	SNAPC4	0.02	0.01	lasso	5	0.02	6.3e-07	9.25	-7.5	4.5e-14	-0.67	0.21	0.77	FALSE
52	YFS	Blood	CARD9	0.22	0.37	lasso	5	0.39	1.3e-137	12.56	12.3	6.3e-35	0.97	0.00	1.00	TRUE
53	YFS	Blood	INPP5E	0.33	0.55	lasso	6	0.57	2.9e-235	10.10	-9.7	2.4e-22	-0.71	1.00	0.00	FALSE
54	YFS	Blood	PMPCA	0.03	0.01	lasso	5	0.02	2.7e-07	9.25	9.4	4.0e-21	0.79	0.08	0.92	FALSE
55	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SEC16A	0.12	0.02	enet	10	0.03	2.2e-03	-0.88	-6.8	1.2e-11	-0.33	0.06	0.07	FALSE
56	The Cancer Genome Atlas	Breast Invasive Carcinoma	SDCCAG3	0.05	0.01	blup	61	0.01	7.9e-04	8.26	-7.2	5.0e-13	-0.47	0.07	0.14	FALSE
57	The Cancer Genome Atlas	Breast Invasive Carcinoma	SEC16A	0.02	0.00	blup	69	0.01	1.0e-03	8.76	-11.2	6.7e-29	-0.67	0.11	0.40	FALSE
58	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	INPP5E	0.25	0.10	lasso	3	0.09	4.9e-05	10.10	-10.2	2.1e-24	-0.71	0.28	0.26	FALSE
59	The Cancer Genome Atlas	Colon Adenocarcinoma	INPP5E	0.11	0.08	lasso	2	0.08	3.4e-05	10.10	-10.1	4.5e-24	-0.72	0.14	0.16	FALSE
60	The Cancer Genome Atlas	Colon Adenocarcinoma	SDCCAG3	0.08	0.01	lasso	4	0.02	3.1e-02	6.08	-8.5	1.7e-17	-0.69	0.04	0.19	FALSE
61	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	INPP5E	0.03	0.01	blup	54	0.01	1.1e-02	10.15	-9.8	7.1e-23	-0.82	0.01	0.74	FALSE
62	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SDCCAG3	0.04	0.05	enet	6	0.04	5.1e-05	6.08	-8.4	4.1e-17	-0.74	0.56	0.39	FALSE
63	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	INPP5E	0.07	0.04	blup	54	0.07	6.0e-05	8.04	-11.1	1.3e-28	-0.82	0.04	0.86	FALSE
64	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SDCCAG3	0.05	0.01	blup	61	0.01	5.9e-02	8.52	-10.6	2.2e-26	-0.85	0.03	0.58	FALSE
65	The Cancer Genome Atlas	Brain Lower Grade Glioma	GPSM1	0.06	0.01	enet	11	0.02	1.0e-03	9.76	-5.6	2.1e-08	-0.66	0.01	0.91	FALSE
66	The Cancer Genome Atlas	Brain Lower Grade Glioma	INPP5E	0.04	0.02	blup	54	0.03	4.4e-04	8.76	-8.9	6.5e-19	-0.68	0.21	0.38	FALSE
67	The Cancer Genome Atlas	Brain Lower Grade Glioma	SNAPC4	0.13	0.05	enet	7	0.06	1.7e-07	7.34	-7.3	3.3e-13	-0.66	0.77	0.09	FALSE
68	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SNAPC4	0.40	0.12	lasso	2	0.11	4.0e-05	3.76	-5.4	6.7e-08	-0.51	0.08	0.05	FALSE
69	The Cancer Genome Atlas	Prostate Adenocarcinoma	INPP5E	0.04	0.02	blup	54	0.02	1.1e-03	3.20	-5.2	2.5e-07	-0.47	0.37	0.13	FALSE
70	The Cancer Genome Atlas	Prostate Adenocarcinoma	SDCCAG3	0.08	0.05	lasso	2	0.05	3.3e-06	6.08	-8.6	1.1e-17	-0.76	0.60	0.33	FALSE
71	The Cancer Genome Atlas	Prostate Adenocarcinoma	SEC16A	0.08	0.10	lasso	4	0.08	1.9e-08	8.03	-8.4	4.0e-17	-0.58	1.00	0.00	FALSE
72	The Cancer Genome Atlas	Rectum Adenocarcinoma	DNLZ	0.75	0.03	enet	20	0.22	7.0e-06	0.71	-7.2	4.7e-13	-0.43	0.00	0.11	FALSE
73	The Cancer Genome Atlas	Testicular Germ Cell Tumors	INPP5E	0.10	0.06	blup	54	0.08	8.1e-04	8.88	-10.7	8.1e-27	-0.84	0.03	0.73	FALSE
74	The Cancer Genome Atlas	Thyroid Carcinoma	INPP5E	0.11	0.16	lasso	3	0.16	2.4e-15	10.15	-10.3	1.1e-24	-0.83	0.84	0.16	FALSE
75	The Cancer Genome Atlas	Thyroid Carcinoma	SDCCAG3	0.16	0.14	lasso	4	0.12	8.2e-12	6.08	-6.2	5.7e-10	-0.58	1.00	0.00	FALSE