Hub : Genes

UBAC1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.143	0.0480	4.9e-03	0.015	NA	0.003	NA	0.012	2.0e-02	NA	1.7e-01	NA	3.3e-02
2	GTEx	Cells Transformed fibroblasts	0.217	0.0680	2.0e-03	-0.001	NA	-0.004	NA	-0.004	4.2e-01	NA	8.5e-01	NA	9.9e-01
3	GTEx	Testis	0.259	0.0800	1.6e-03	-0.001	NA	0.031	NA	0.033	3.6e-01	NA	1.6e-02	NA	1.3e-02
4	METSIM	Adipose	0.172	0.0332	1.9e-10	0.086	0.092	0.100	0.105	0.109	6.9e-13	1.1e-13	1.1e-14	2.3e-15	5.8e-16
5	YFS	Blood	0.148	0.0234	0.0e+00	0.103	0.078	0.103	0.107	0.101	5.1e-32	3.9e-24	7.3e-32	4.1e-33	2.6e-31
6	TCGA	Thyroid Carcinoma	0.108	0.0380	1.1e-05	0.012	0.051	0.033	NA	0.033	2.1e-02	1.1e-05	3.2e-04	NA	3.2e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.2	0.4	1.9	0.5	-0.3	0.1	0.2	-0.3	1.4
Bipolar Disorder or Schizophrenia	0.1	0.2	0.9	0.1	0.0	-0.9	-0.1	0.4	-0.0
Depressed Affect (Nagel 2018)	0.5	1.1	4.6	0.7	0.1	-2.1	1.0	-0.6	0.6
Depression (Nagel 2018)	1.0	1.5	4.1	0.3	2.0	-2.0	0.6	0.2	0.8
Intelligence (Savage-Jansen 2018)	0.5	1.6	5.2	-0.4	0.4	-2.3	1.3	-1.5	0.1
Neuroticism (Nagel 2018)	0.8	1.9	3.5	1.5	0.9	-1.9	1.4	-1.2	1.2
Schizophrenia (2018)	0.3	0.6	1.6	-0.2	0.3	-1.3	-0.2	0.8	-1.0
Schizophrenia vs Biploar Disorder	0.7	0.9	2.1	-0.1	-0.7	-1.0	-0.3	1.5	-1.3
Worry (Nagel 2018)	1.5	3.3	6.2	2.5	1.0	-1.9	2.1	-1.7	1.4
Alzheimer’s Disease (in mother)	0.3	0.4	0.9	-0.4	0.8	-0.0	0.3	-0.9	-0.7
Alzheimer’s Disease (in father)	0.6	0.7	1.6	-1.2	0.7	-0.4	-0.4	1.3	-0.2
Alzheimer’s Disease (including proxy)	0.2	0.3	1.1	-0.1	1.0	-0.2	0.3	-0.6	0.1
Crohns Disease (2017)	1.9	4.1	15.5	-0.5	3.9	2.2	-0.2	1.0	1.8
Irritable Bowel Disease (IBD)	3.2	7.7	31.8	0.9	5.6	2.7	0.2	-0.3	2.5
Ulcerative Colitis (UC)	2.7	5.0	20.0	1.6	4.5	1.4	0.7	-1.4	1.7
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	1.1	2.1	5.6	-0.0	1.1	2.4	-1.6	1.6	0.8
Verbal and Numeric Reasoning (VNR)	0.6	1.5	5.6	-0.9	-0.1	-2.4	0.9	-1.1	-0.6
Breast Cancer	0.4	1.0	4.0	-0.5	-2.0	-0.5	-0.9	0.8	-0.2
Ovarian Cancer	0.7	1.0	3.7	0.5	1.9	0.9	-1.0	0.4	0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.9	1.3	2.9	1.2	0.2	-0.2	1.2	-1.7	1.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.4	-0.2	-1.2	-0.6	0.2	0.4	-0.4
Coronary Artery Disease (CAD)	0.0	0.0	0.1	0.0	0.0	0.0	0.0	-0.4	0.0
Crohns Disease (2012)	1.7	2.8	10.6	-0.5	3.3	2.0	-0.4	1.4	0.0
Mean Putamen Volume	0.1	0.1	0.3	-0.3	-0.0	-0.2	0.2	-0.5	0.2
Fasting Glucose	1.6	2.0	3.8	-1.1	1.2	1.3	-1.9	1.9	-0.4
HbA1C	0.8	0.9	2.4	1.5	-0.8	-0.7	1.0	-0.8	0.6
HDL Cholesterol	0.2	0.4	1.0	0.7	0.3	-1.0	-0.1	0.8	-0.4
LDL Cholesterol	0.1	0.2	0.8	-0.3	-0.9	-0.2	0.0	0.3	0.1
Lupus	0.4	0.6	2.5	0.3	-0.4	-0.2	-0.8	1.6	0.2
Neuroticism (2016)	0.3	0.4	0.7	-0.5	0.9	-0.3	-0.8	0.8	-0.1
Primary Biliary Cirrhosis	0.7	1.0	2.6	1.6	1.3	0.2	0.7	-1.1	0.6
Rheumatoid Arthritis	1.5	2.0	4.5	0.7	-1.6	-1.2	1.6	-2.1	0.6
Schizophrenia (2014)	0.2	0.4	2.0	0.3	0.0	-1.4	0.4	-0.3	-0.6
Triglycerides	0.3	0.5	0.9	-0.7	0.8	0.9	-0.9	0.0	-0.2
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.5	0.3	-0.4	-0.0	0.1	-0.3	0.7
Ulcerative Colitis	2.6	3.8	14.5	1.7	3.8	1.8	0.2	-0.7	1.2
Blood Eosinophil Count	0.2	1.5	3.0	-1.4	-0.8	-1.4	-0.3	1.2	-1.7
Blood Platelet Count	0.1	1.3	2.6	-1.1	1.2	1.6	-1.3	0.0	1.0
Blood Red Count	0.2	2.0	3.6	-1.9	1.3	0.3	-0.9	1.8	-1.7
Blood White Count	1.0	7.2	16.9	-2.4	4.1	1.8	-3.0	2.5	-1.3
Heel T-Score	0.1	1.2	5.8	-0.2	0.4	-0.1	-0.5	0.9	-2.4
BMI	0.1	0.8	3.2	0.5	0.3	-1.0	1.8	-0.3	-0.2
Height	0.4	8.6	24.9	-2.3	5.0	1.5	-1.9	3.7	-1.4
Waist Hip Ratio (WHR)	0.3	1.3	2.3	-1.5	-0.7	1.5	-0.9	1.5	0.2
Systolic Blood Pressure	0.6	2.8	7.4	2.0	-0.9	0.2	1.2	-1.8	2.7
Smoking Status	1.0	2.5	4.2	1.6	-1.0	-1.4	2.0	-1.5	1.6
Allergy or Eczema	0.1	0.2	0.6	-0.3	0.2	-0.2	0.6	-0.6	0.8
Cardiovascular Disease	0.2	0.6	1.4	-0.2	0.5	-0.4	1.2	-0.6	1.0
Hypothyroidism (self reported)	0.7	1.6	3.6	0.7	-1.5	-1.9	1.4	-0.4	-1.0
Respiratory disease	0.3	0.6	1.1	-0.9	0.9	-0.8	0.6	0.1	-1.1
Type 2 Diabetes (T2D) (2018)	0.8	1.4	2.5	-1.5	-0.1	0.6	-1.6	1.1	-1.5
Lung FEV1/FVC ratio	0.1	0.6	1.7	0.3	-0.3	0.4	-0.6	1.3	1.1
Lung FVC	1.5	7.9	12.0	2.5	-3.4	-2.4	2.8	-3.5	1.8
Neuroticism	0.5	1.3	4.9	0.7	0.9	-2.2	1.1	-0.5	-0.3
Chronotype (morning person)	0.6	1.4	4.7	0.3	2.2	1.6	-0.3	-0.8	-0.3
Hair Pigment	0.2	6.6	11.6	2.8	-0.9	-3.1	3.4	-2.9	1.2
Tanning	0.2	2.7	6.9	-1.1	0.4	2.3	-2.6	1.4	-0.4
Hand grip strength (left)	0.6	1.5	4.9	1.1	-0.6	-0.4	1.5	-2.2	0.7
Number of treatments/medications taken	0.5	0.9	2.0	-0.3	-0.2	-1.0	1.4	-1.0	1.1
Average weekly spirits intake	0.5	0.6	2.2	-0.2	-0.4	1.0	0.3	-1.5	-0.5
Sensitivity / hurt feelings	0.5	0.8	3.3	0.1	0.6	-1.8	0.9	0.5	-0.4
Frequency of depressed mood in last 2 weeks	1.2	1.7	7.3	0.3	2.7	-1.4	0.3	-0.2	0.9
Hearing difficulty/problems: Yes	0.7	1.0	2.1	0.1	1.4	0.9	0.1	-1.4	-1.0
Relative age of first facial hair	0.3	0.5	1.4	0.1	1.0	1.2	-0.6	-0.1	0.7
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.1	0.7	0.3	-0.6	0.6	-1.4	-0.9
Ever used hormone-replacement therapy (HRT)	1.6	2.1	4.6	1.6	1.0	-1.0	2.1	-1.0	1.5
Ever had hysterectomy (womb removed)	0.6	0.6	1.6	-1.3	-0.2	1.2	-0.8	0.4	-0.0
Systolic blood pressure, automated reading	0.4	1.3	4.1	1.1	0.1	1.3	0.7	-0.3	2.0
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.8	-0.0	0.8	1.7	-1.0	1.6	0.5
Angina	0.5	0.7	2.7	-1.7	-0.1	-0.1	-0.7	1.0	-0.2
Medication for hormone replacement therapy	0.7	0.7	2.2	1.5	0.4	-0.1	0.4	-1.3	0.5
Vitamin and mineral supplements	0.4	0.5	1.6	-1.3	-0.7	0.3	-0.6	-0.0	-0.6
Supplements: Zinc	0.4	0.5	1.3	0.7	0.9	-0.1	0.5	-1.1	0.2
Medication: Co-codamol	0.2	0.2	0.6	-0.2	-0.3	0.8	-0.4	-0.4	-0.4
Medication: Metformin	2.7	3.9	9.2	-1.8	0.5	2.7	-3.0	1.7	-0.5
Diabetes (father)	0.7	0.9	2.2	-0.0	-0.9	-0.0	-1.1	1.1	-1.5
Diabetes (mother)	1.4	1.8	5.4	-1.4	-0.6	-1.6	-0.4	0.8	-2.3
Severe depression (siblings)	0.9	1.0	2.0	0.9	0.1	-1.1	1.4	-1.1	1.1
Pack years adult smoking proportion	1.9	2.8	4.8	-2.2	1.3	1.7	-1.5	1.1	-2.0
Impedance of leg (right)	0.1	0.5	1.0	0.3	0.3	-1.0	0.8	0.2	1.0
Leg fat-free mass (left)	0.6	2.9	10.4	-1.0	3.2	1.4	-0.8	1.6	-1.1
Trunk fat percentage	0.2	0.9	2.9	-0.3	0.6	-1.0	1.0	1.7	0.0
Hand grip strength (right)	0.5	1.4	5.1	0.9	0.1	-0.4	1.3	-2.3	0.8
Townsend deprivation index at recruitment	0.9	1.3	1.9	-1.4	-1.1	0.9	-0.8	1.3	-1.2
Current tobacco smoking	1.0	1.6	3.2	-1.8	1.8	1.1	-1.0	0.7	-0.6
Average weekly fortified wine intake	0.1	0.1	0.2	0.0	-0.3	0.0	-0.2	-0.1	-0.5
Maternal smoking around birth	0.3	0.4	0.8	-0.7	0.5	-0.4	0.3	0.9	-0.8
Fed-up feelings	0.6	1.0	3.3	-0.2	-1.5	-1.8	0.4	0.6	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	2.7	-1.6	1.0	-1.2	-0.5	0.7	-1.1
Relative age voice broke	0.2	0.4	0.7	-0.7	0.4	0.8	-0.8	0.4	0.2
Taking other prescription medications	0.5	0.8	2.1	-1.4	0.8	0.4	-0.6	0.8	-0.9
Age when periods started (menarche)	0.6	1.5	4.6	-1.1	-0.6	-0.2	-1.1	1.3	-2.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.4	-0.6	-0.3	0.4	-0.7	0.0	-1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.5	-0.6	1.2	-0.3	0.0	0.3	-0.5
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.7	0.3	-1.2	1.3	-1.3	-0.2	0.2
Qualifications: CSEs or equivalent	0.5	0.7	1.8	-0.4	-0.1	0.6	-1.3	1.4	-0.1
Serious illness, injury or assault to yourself	0.8	0.9	2.3	-1.5	0.2	1.1	-1.3	0.4	-0.4
High blood pressure	0.2	0.6	1.7	-0.2	0.5	0.7	0.6	-0.8	1.3
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.5	-0.4	-1.2	-1.0	0.4	-0.7	0.6
Multivitamins +/- minerals	0.4	0.5	0.8	0.8	-0.5	-0.9	0.9	-0.4	0.8
Stomach or abdominal pain in last month	1.0	1.2	3.6	-0.0	-0.3	-1.1	1.5	-1.9	0.1
Supplements: Glucosamine	0.1	0.1	0.7	0.1	0.8	0.1	0.3	-0.1	0.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.0	-0.4	-1.0	-0.6	0.9	-0.9	1.0
Medication: Atenolol	0.3	0.4	0.8	-0.6	-0.9	-0.9	0.4	-0.1	-0.7
Medication: Levothyroxine sodium	0.4	0.7	1.4	0.3	-1.0	-1.2	0.9	-0.6	-0.6
Sitting height	2.0	13.9	26.6	-2.6	5.2	3.6	-3.9	4.1	-2.3
Chronic bronchitis/emphysema (father)	0.6	0.8	1.7	-1.3	0.6	0.4	-0.7	0.4	-1.3
High blood pressure (mother)	0.6	0.9	2.1	-1.0	0.2	1.4	-1.4	0.4	0.2
Body mass index (BMI)	0.1	0.2	0.9	-0.2	-0.1	-0.3	0.9	0.4	-0.4
Impedance of leg (left)	0.1	0.6	2.0	0.3	0.0	-1.4	0.6	0.7	0.8
Leg predicted mass (left)	0.6	3.0	10.3	-1.0	3.2	1.3	-0.9	1.6	-1.2
Trunk fat mass	0.3	1.1	3.4	-0.5	1.4	-0.4	0.7	1.9	-0.3
Waist circumference	0.3	0.9	2.3	-0.9	1.4	0.7	0.1	1.5	-0.5
Number of incorrect matches in round	0.3	0.4	0.8	0.1	-0.8	0.6	-0.9	0.8	-0.5
Past tobacco smoking	1.9	3.5	6.1	-0.4	2.5	2.2	-2.1	2.3	-0.6
Alcohol usually taken with meals	1.6	2.5	7.9	1.9	1.6	-0.1	0.7	-0.8	2.8
Nervous feelings	0.9	1.7	5.7	2.4	0.8	-0.9	1.4	-0.6	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	3.5	0.0	0.5	-1.9	0.9	-0.7	0.9
Hearing difficulty/problems with background noise	0.8	1.3	4.8	0.3	0.5	-0.8	1.3	-2.2	0.0
Hair/balding pattern: Pattern 2	1.4	1.8	3.6	-0.9	0.7	1.9	-1.6	1.5	-1.2
Had menopause	0.4	0.5	1.5	-0.1	0.3	-0.9	1.2	-0.6	0.3
Had other major operations	0.5	0.6	2.8	-0.7	0.4	1.7	-0.3	0.2	-0.3
Forced vital capacity (FVC)	0.5	1.9	3.7	1.9	0.3	-1.5	1.8	-1.3	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	0.8	-0.9	0.9	-0.5	-0.2	0.7	-0.7
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	4.1	0.3	2.0	-0.3	1.0	-1.4	-0.2
Qualifications: None of the above	0.7	1.4	7.5	-0.2	-2.7	-0.5	0.1	0.5	-0.8
Financial difficulties in last 2 years	0.1	0.2	0.6	0.3	0.3	-0.8	0.5	0.3	0.1
Mouth/teeth dental problems	1.5	2.3	4.5	2.1	-0.4	-0.2	1.1	-1.9	2.0
Heart attack	0.1	0.2	0.6	-0.2	-0.5	-0.8	0.2	-0.1	0.0
Allergy	0.2	0.4	2.2	1.5	0.1	-0.0	0.5	-0.3	-0.2
Pain all over the body in last month	0.3	0.3	0.7	-0.0	0.8	-0.2	-0.7	0.6	-0.5
Diabetes (self-reported)	1.2	1.8	2.9	-1.6	-1.2	0.4	-1.7	1.1	-1.5
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	2.7	-1.6	-0.5	-0.4	-0.3	0.1	-0.7
Medication: Ramipril	0.3	0.4	0.8	0.1	-0.8	-0.4	-0.6	0.9	0.7
Medication: Simvastatin	0.7	1.0	4.3	-2.1	0.1	1.2	-0.4	0.1	-0.3
Fluid intelligence score	0.8	1.6	4.0	0.2	0.9	-2.0	1.4	-1.7	-0.2
Illnesses of siblings	0.4	0.6	1.3	1.0	-0.1	-0.5	1.1	-0.2	0.8
Neuroticism score	0.3	0.7	3.1	0.6	0.3	-1.8	0.7	-0.1	-0.1
Weight	0.4	2.0	7.0	-0.8	2.6	0.6	-0.1	1.8	-0.8
Impedance of arm (right)	0.2	0.7	2.1	0.4	0.5	-1.1	-0.3	1.4	0.6
Arm fat percentage (right)	0.1	0.6	1.3	0.1	-0.0	-0.8	1.1	1.1	-0.7
Trunk fat-free mass	0.6	3.6	14.4	-0.7	3.8	1.9	-0.9	1.1	-1.0
Hip circumference	0.2	1.0	4.5	0.2	2.1	-0.1	0.7	0.9	-0.6
Time employed in main current job	0.3	0.3	0.9	-0.1	0.6	1.0	-0.6	0.4	0.1
Alcohol intake versus 10 years previously	0.5	0.7	1.7	-1.2	-1.3	-0.4	-0.4	0.5	-0.6
Father’s age at death	0.5	0.7	1.2	-1.1	-1.1	1.0	-0.7	-0.3	0.2
Worrier / anxious feelings	0.6	1.1	4.2	0.2	-2.1	-1.1	0.6	-0.5	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	2.6	0.5	-0.1	-1.5	1.3	-1.6	0.5
Falls in the last year	0.8	1.1	3.0	-0.5	1.1	1.4	-0.2	-0.3	-1.7
Hair/balding pattern: Pattern 3	0.5	0.8	1.7	-1.3	-1.1	-0.5	0.1	-1.3	-0.3
Number of live births	0.3	0.5	1.0	-1.0	0.4	-0.2	-0.5	0.9	-0.8
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	6.4	2.5	-0.1	-1.5	1.9	-1.5	1.1
Pulse rate	0.6	1.0	1.6	-1.3	0.3	1.2	-0.9	0.9	-1.0
Happiness	0.7	0.9	2.4	-0.8	-1.6	-0.8	0.3	-0.9	0.6
Noisy workplace	0.7	0.9	2.0	-1.1	-1.2	-0.6	-0.2	0.2	-1.4
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.2	0.7	0.4	-1.4	0.8	-1.5	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	3.3	-1.1	0.3	-1.8	0.5	-0.2	-0.4
Mouth/teeth dental problems: Dentures	1.0	1.6	2.8	-1.6	0.8	1.7	-1.5	0.6	-1.0
Asthma	0.3	0.6	2.4	-1.6	0.3	0.5	-0.7	0.7	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.8	0.8	0.9	0.1	0.3	-0.5	-0.1
Medication: Cholesterol lowering	0.9	1.4	2.8	-0.5	-0.9	-1.7	1.3	-1.7	0.2
Depression (self-reported)	3.2	3.9	11.1	2.2	0.9	-0.8	2.1	-3.3	1.2
Medication: Lansoprazole	0.7	0.8	1.8	0.5	1.4	1.0	0.5	-0.1	1.2
Prospective memory result	0.4	0.5	1.0	0.4	-0.9	1.0	-0.4	0.4	0.9
Lung cancer (father)	0.6	0.6	2.7	0.5	1.6	0.0	0.5	-0.9	-0.0
Illnesses of mother	1.2	1.5	3.8	2.0	-1.6	-0.5	0.8	-0.6	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	5.4	2.3	-0.1	-0.6	1.5	-1.3	1.3
Pulse wave Arterial Stiffness index	0.5	0.6	1.9	-0.0	-0.5	-1.0	1.4	-0.8	0.2
Impedance of arm (left)	0.2	0.9	2.8	0.1	0.5	-1.2	-0.6	1.7	0.5
Arm fat mass (right)	0.2	0.7	1.7	-0.3	1.0	-0.2	0.7	1.3	-0.8
Trunk predicted mass	0.7	3.7	14.7	-0.7	3.8	2.0	-1.0	1.2	-1.0
Standing height	1.0	10.1	36.6	-1.6	6.0	1.9	-2.2	3.4	-1.1
Length of working week for main job	2.2	2.4	4.1	2.0	0.3	-1.1	1.9	-1.3	2.0
Exposure to tobacco smoke at home	1.2	1.3	2.2	1.2	-1.1	-1.5	1.1	-1.2	0.3
Breastfed as a baby	0.6	0.7	1.5	-0.8	0.4	0.9	-0.2	-1.2	-1.0
Tense / ‘highly strung’	0.3	0.5	0.8	0.3	0.9	-0.3	0.6	-0.8	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	2.8	4.3	7.2	2.7	2.5	-0.8	1.5	-2.3	2.1
Hair/balding pattern: Pattern 4	0.0	0.0	0.3	0.1	0.1	0.5	0.0	-0.0	-0.0
Birth weight of first child	0.4	0.7	3.0	-0.1	1.7	0.2	-0.8	0.8	-0.3
Peak expiratory flow (PEF)	2.0	4.6	7.7	2.4	-1.1	-2.1	2.6	-2.8	1.2
Pulse wave reflection index	1.2	1.5	4.4	0.2	-1.0	-2.1	1.4	-0.8	0.7
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.9	-0.6	0.9	0.6	0.4	-0.6	-0.2
Loud music exposure frequency	0.2	0.2	0.6	0.3	0.8	-0.4	0.3	0.3	0.5
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.4	0.6	0.4	-0.2	-0.2	0.3	-0.3
Mouth/teeth dental problems: Bleeding gums	2.9	3.8	10.7	-2.6	-0.4	-1.0	-0.7	1.9	-3.3
Blood clot in the leg (DVT)	2.4	3.1	5.5	-2.1	1.3	1.1	-1.9	1.5	-2.3
Medication: Paracetamol	0.2	0.3	0.9	-0.3	0.2	-0.6	0.5	-0.9	-0.0
Headache pain in last month	0.1	0.1	0.5	-0.2	0.1	-0.4	0.7	0.0	0.2
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	3.9	-0.3	0.4	1.4	-1.5	2.0	-0.4
Glaucoma (self-reported)	0.4	0.5	1.6	-0.3	1.3	0.7	-0.5	0.7	-0.5
Gout (self-reported)	0.1	0.2	0.7	0.4	0.1	-0.8	0.5	0.1	-0.4
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.7	0.6	-1.1	-1.6	1.1	-0.8	-1.2
Medication: Amlodipine	0.5	0.8	2.8	-1.7	-1.0	0.6	-0.5	-0.1	0.5
Medication: Ventolin 100micrograms inhaler	1.2	1.5	7.2	-0.0	2.7	1.2	-0.5	0.4	0.4
Birth weight	0.9	1.9	9.0	0.6	3.0	0.2	0.3	-1.1	0.7
Chronic bronchitis/emphysema (mother)	0.5	0.6	2.0	-0.9	1.4	0.3	-0.2	0.8	0.2
High blood pressure (siblings)	0.6	0.8	2.1	-1.2	0.7	1.4	-0.6	-0.1	-0.8
Forced vital capacity (FVC), Best measure	0.6	2.3	4.7	2.2	0.4	-1.0	1.7	-1.7	1.3
Body fat percentage	0.2	0.9	2.1	0.0	0.2	-1.1	1.5	1.3	0.1
Leg fat percentage (right)	0.3	1.1	4.3	0.8	0.2	-1.1	2.1	0.3	0.3
Arm fat-free mass (right)	0.5	2.5	8.2	-1.3	2.9	1.4	-0.4	1.3	-1.2
Exposure to tobacco smoke outside home	1.7	2.2	6.9	0.2	-0.9	-2.6	1.6	-1.6	-0.7
Comparative body size at age 10	0.3	0.7	2.2	0.7	0.4	-0.2	0.7	-1.5	1.0
Number of full brothers	0.5	0.6	1.4	-0.9	1.2	-0.3	-0.0	0.0	-1.1
Worry too long after embarrassment	0.3	0.4	0.6	-0.7	0.2	0.6	-0.8	0.6	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	5.3	1.4	2.3	0.6	0.8	-0.4	0.5
Wheeze or whistling in the chest in last year	0.3	0.5	1.1	-0.2	0.5	-1.1	1.0	-0.4	0.9
Number of children fathered	0.9	1.0	3.0	0.5	0.1	-1.2	1.7	-0.9	0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	4.5	1.1	-1.8	-2.1	1.0	-0.6	0.4
Age at first live birth	0.1	0.2	0.8	0.3	-0.3	-0.2	0.2	-0.5	0.9
Pulse wave peak to peak time	0.7	0.8	2.0	-0.0	0.8	0.9	-1.4	1.0	-0.4
Health satisfaction	1.1	1.5	3.7	-1.4	-0.0	0.5	-1.2	1.9	-1.2
Shortness of breath walking on level ground	1.3	1.5	2.8	-0.7	-1.7	-1.0	1.3	-0.8	-1.5
Qualifications: College or University degree	0.2	0.5	1.1	0.1	1.1	0.3	-0.3	-1.0	-0.7
Eye problems/disorders: None of the above	0.3	0.3	1.4	-0.3	-1.2	-0.3	0.5	-0.3	0.3
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.1	0.6	-0.8	-1.0	-0.1	0.8	-0.8
Emphysema/chronic bronchitis	3.1	3.5	6.1	2.4	0.2	-2.5	2.5	-1.8	0.1
Medication for pain relief, constipation, heartburn	0.1	0.2	0.8	0.6	-0.9	-0.3	-0.1	-0.4	0.1
Neck or shoulder pain in last month	0.4	0.6	1.5	-1.2	-0.1	0.3	-0.5	0.8	-1.0
Medication: Blood pressure	0.2	0.4	1.1	0.1	-0.6	-0.5	0.9	-1.0	0.4
Angina (self-reported)	0.5	0.6	2.8	-1.7	-0.0	-0.3	-0.6	0.7	-0.3
Migraine (self-reported)	0.3	0.4	0.9	-0.5	-0.4	0.2	-0.4	-0.9	0.9
Medication: Ibuprofen	0.5	0.5	1.1	1.0	1.0	-0.6	0.8	-0.5	0.2
Medication: Allopurinol	0.3	0.4	0.8	-0.2	-0.0	-0.7	-0.2	0.9	-0.9
Medication: Omeprazole	0.8	1.0	2.4	-1.4	-0.6	-0.9	-0.1	1.5	-0.7
Medication: Seretide 50 evohaler	2.3	2.6	5.5	-2.0	0.0	2.3	-2.0	1.4	-0.3
Mean time to correctly identify matches	1.0	2.0	4.6	-0.9	0.8	2.1	-2.0	1.3	0.5
Heart disease (mother)	1.4	1.8	4.7	-1.4	2.2	0.6	-1.2	0.8	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	4.8	-1.5	-1.1	-1.5	-0.0	0.8	-2.2
Whole body fat mass	0.2	0.9	2.3	-0.2	1.2	-0.5	1.1	1.5	-0.5
Leg fat mass (right)	0.2	0.8	2.4	0.2	1.2	-0.5	1.6	0.7	-0.3
Arm predicted mass (right)	0.4	2.3	8.9	-1.1	3.0	1.2	-0.2	0.9	-1.1
Pulse rate, automated reading	0.9	2.9	7.2	-0.4	2.7	0.8	-1.4	2.5	-1.0
Alcohol intake frequency.	1.8	4.1	8.1	-2.2	-0.4	1.7	-2.6	2.9	-1.3
Comparative height size at age 10	0.6	3.0	13.7	0.1	3.7	1.5	-0.7	1.3	0.1
Number of full sisters	1.1	1.4	4.0	-0.8	1.3	2.0	-1.1	0.7	0.3
Suffer from ‘nerves’	1.4	2.2	3.2	1.8	1.6	-1.6	1.3	-1.1	1.3
Overall health rating	0.3	0.7	2.5	0.3	-0.4	-1.6	1.0	0.3	-0.6
Chest pain or discomfort	0.5	0.7	1.7	-1.2	0.8	-0.3	0.5	-0.3	-1.3
Had major operations	0.4	0.5	1.2	1.0	0.7	0.0	0.3	-1.1	0.6
Age at last live birth	0.3	0.4	1.0	0.2	-1.0	-0.1	-0.0	1.0	0.6
Family relationship satisfaction	0.6	0.8	1.7	-1.1	-0.3	0.6	-1.3	0.3	-1.2
Leg pain on walking	1.8	2.2	4.9	-2.2	-1.1	0.3	-1.5	1.4	-1.8
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.6	-0.2	0.8	-0.4	-0.1	0.8	0.6
Commuting to job workplace: Car/motor vehicle	1.2	1.3	2.7	0.5	1.6	0.3	0.7	-1.5	1.5
Illness, injury, bereavement, stress in last 2 years	1.6	1.9	4.3	2.1	-1.5	-1.2	0.9	-1.1	1.1
Medication: Aspirin	0.7	0.9	2.9	-0.3	-0.4	-0.7	1.1	-0.7	1.7
Supplements: Vitamin C	0.8	1.0	2.8	0.7	1.5	1.7	-0.5	0.1	-0.3
Knee pain experienced in last month	0.4	0.7	2.4	0.1	-0.3	-1.6	1.0	-0.8	0.0
Hypertension (Self-reported)	0.2	0.5	1.8	-0.5	0.5	0.7	0.5	-0.5	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.2	3.1	-1.8	0.2	-0.1	0.3	1.2	-1.6
Illnesses of father: Heart disease	2.3	3.2	5.8	-2.4	-0.4	0.9	-1.9	2.2	-2.0
Illnesses of siblings: Diabetes	0.4	0.5	1.8	-1.0	-0.1	0.5	-1.3	0.4	-0.2
Smoking status: Previous	2.6	3.9	7.4	1.2	-2.7	-1.7	2.2	-2.3	1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	8.6	-0.8	1.7	1.4	-1.8	2.9	-1.6
Whole body fat-free mass	0.6	3.3	12.6	-0.9	3.6	1.7	-0.8	1.4	-1.1
Leg fat-free mass (right)	0.6	3.0	9.5	-0.9	3.1	1.3	-1.1	1.8	-1.1
Arm fat percentage (left)	0.2	0.6	1.3	0.0	-0.2	-0.9	1.1	1.1	-0.6
Average weekly red wine intake	1.4	2.0	6.0	2.4	1.1	0.0	0.5	-1.1	1.9
Handedness (chirality/laterality): Left-handed	2.6	3.1	6.7	2.6	0.4	-2.2	1.6	-1.0	1.8
Mood swings	0.4	0.7	1.8	1.4	0.6	-1.1	0.4	-0.4	0.4
Loneliness, isolation	0.6	0.8	4.7	0.1	2.2	-0.4	-0.0	-0.0	-0.5
Long-standing illness, disability or infirmity	1.3	2.0	5.4	-1.1	0.8	0.8	-1.4	1.4	-2.3
Ever had bowel cancer screening	0.2	0.2	1.0	0.1	1.0	0.3	0.1	0.0	-0.3
Diabetes diagnosed by doctor	2.4	4.0	7.3	-2.7	-0.8	1.6	-2.7	1.8	-1.8
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	3.0	-0.6	1.3	1.2	-1.0	0.8	-1.7
Friendships satisfaction	0.3	0.4	0.9	-0.5	-0.9	-0.3	-0.5	0.6	-0.5
Qualifications: nursing, teaching	1.4	2.2	4.2	1.0	0.3	-0.3	2.0	-1.9	2.0
Commuting to job workplace: Walk	1.7	1.8	8.5	0.6	-2.9	-1.1	0.2	-0.7	-0.6
Eye problems/disorders: Cataract	1.3	1.5	2.8	1.7	-0.1	-1.2	1.5	-1.1	1.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.2	0.3	-0.6	-0.4	0.4	-0.5	0.5	-0.6
Medication for cholesterol	0.2	0.3	1.3	1.1	-0.2	-0.5	-0.1	0.1	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	3.1	0.5	-0.3	-1.8	0.8	-0.2	0.2
Back pain experienced in last month	1.0	1.5	5.3	-0.6	2.3	0.2	0.1	-0.2	-1.8
Mineral and other dietary supplements	1.6	2.1	4.7	-2.2	-0.1	1.2	-1.7	1.4	-1.4
Breast cancer (self-reported)	0.0	0.1	0.2	0.0	-0.0	-0.3	0.0	0.0	-0.5
Asthma (self-reported)	0.2	0.4	2.0	-1.4	0.3	0.4	-0.4	0.4	0.2
Osteoporosis (self-reported)	0.4	0.4	2.4	-0.2	-0.1	-0.3	-0.2	0.1	-1.5
Osteoarthritis (self-reported)	0.7	0.9	2.2	-0.6	-0.5	-0.2	-0.6	1.4	-1.5
Medication: Aspirin	1.0	1.3	2.6	-0.3	-1.0	-1.2	1.2	-1.0	1.6
Medication: Gliclazide	0.1	0.1	0.2	0.2	-0.3	-0.4	-0.2	-0.1	-0.2
Illnesses of father: None of the above (group 1)	1.8	2.3	3.9	1.8	0.7	-0.6	1.7	-1.7	2.0
Smoking status: Current	0.7	1.2	3.5	-1.4	1.9	0.9	-0.7	0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	5.9	1.3	-1.5	-1.7	2.4	-2.3	0.9
Whole body water mass	0.6	3.4	13.0	-0.9	3.6	1.8	-0.8	1.3	-1.0
Leg predicted mass (right)	0.5	2.9	9.1	-0.9	3.0	1.3	-1.0	1.7	-1.2
Arm fat mass (left)	0.2	0.7	2.3	-0.5	0.8	-0.2	0.6	1.5	-0.9
Number of self-reported non-cancer illnesses	0.4	0.7	1.7	-1.3	-0.3	-0.8	0.8	-0.9	0.4
Average weekly champagne plus white wine intake	1.1	1.5	3.1	1.8	1.5	-0.2	1.4	-1.1	0.6
Miserableness	0.2	0.4	1.7	-0.4	0.1	-1.3	0.1	-0.5	0.3
Guilty feelings	0.2	0.4	1.3	1.1	-0.1	-0.5	0.2	0.5	0.6
Wears glasses or contact lenses	0.6	0.7	2.2	-1.5	0.6	0.6	-0.5	-1.0	0.2
Ever taken oral contraceptive pill	0.6	0.7	3.6	0.3	-0.1	-1.9	0.4	0.1	-0.4
Hearing aid user	0.8	0.9	2.7	0.9	1.2	0.6	0.2	-1.6	-0.3
Mother’s age at death	1.6	2.0	5.6	-2.4	-1.7	0.8	-0.9	1.0	-1.0
Financial situation satisfaction	0.2	0.3	0.6	-0.7	-0.7	-0.3	-0.0	0.8	0.3
Tinnitus: Yes, now most or all of the time	0.8	1.0	2.2	-1.5	-0.1	0.7	-1.0	0.8	-1.2
Commuting to job workplace: Public transport	0.4	0.5	2.1	-0.4	-0.2	0.5	-0.6	0.2	-1.4
Eye problems/disorders: Glaucoma	0.7	0.9	1.8	-0.6	1.0	0.7	-1.1	1.3	-0.6
Medication: Blood pressure	0.3	0.6	1.9	-0.8	-0.1	0.8	0.4	-0.2	1.4
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.8	-0.0	0.5	0.6	-0.0	-1.0	1.4
Supplements: Fish oil (including cod liver oil)	1.2	1.6	2.7	1.4	-0.6	-1.2	1.5	-1.6	0.9
High cholesterol (Self-reported)	0.3	0.5	1.9	-1.4	0.5	0.8	-0.4	-0.0	-0.0
Medication: Bendroflumethiazide	0.5	0.8	4.3	-0.5	0.1	0.1	-0.0	-0.4	2.1
Medication: Paracetamol	0.3	0.5	1.0	-0.6	-0.2	-1.0	0.9	-0.9	0.1
Medication: Lisinopril	0.6	0.8	1.6	-0.5	1.1	1.1	-0.2	0.5	-1.3
Medication: Atorvastatin	0.5	0.6	2.1	-0.9	0.4	-1.4	0.3	-0.6	0.2
Illnesses of father: High blood pressure	0.6	0.7	2.6	1.6	-0.1	-0.1	0.5	-1.0	0.4
Alcohol drinker status: Never	0.2	0.3	0.7	-0.1	0.2	0.5	-0.8	0.3	0.8
Ever smoked	2.5	4.4	7.0	0.9	-2.3	-2.6	2.5	-2.6	0.4
Basal metabolic rate	0.6	3.2	11.7	-0.9	3.4	1.4	-0.7	1.7	-1.0
Leg fat percentage (left)	0.3	0.9	3.1	0.6	0.1	-1.2	1.8	0.7	0.1
Arm fat-free mass (left)	0.6	2.8	9.8	-1.2	3.1	1.5	-0.5	1.6	-0.9
Number of operations (self-reported)	0.1	0.1	0.5	-0.3	0.3	0.7	-0.1	-0.1	-0.1
Average weekly beer plus cider intake	1.1	1.6	4.4	-2.0	-0.7	-0.2	-0.5	0.4	-2.1
Irritability	0.2	0.4	0.9	0.3	0.1	-0.9	0.2	-0.7	0.9
Risk taking	0.8	1.1	2.8	0.4	1.7	0.6	0.4	-0.5	1.7
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.8	0.3	-1.0	-1.9	0.7	-1.8	0.3
Fractured/broken bones in last 5 years	2.1	2.6	4.7	-1.3	0.8	2.2	-2.1	1.0	-1.8
Age started oral contraceptive pill	0.6	0.8	1.7	-1.3	1.2	0.5	-0.2	0.3	-1.1
Diastolic blood pressure, automated reading	0.5	1.4	4.6	0.5	2.1	1.2	0.3	0.1	1.5
Ever depressed for a whole week	2.6	3.1	6.1	1.7	-0.5	-2.3	2.5	-1.3	1.6
Unable to work because of sickness or disability	0.7	0.9	1.8	-1.4	-1.1	0.3	-0.9	-0.1	-1.3
Commuting to job workplace: Cycle	1.7	2.0	5.2	-0.2	-2.3	-1.7	-0.1	0.0	-2.0
Myopia	0.1	0.1	0.3	-0.0	0.6	-0.0	0.0	-0.1	-0.4
Vascular/heart problems diagnosed by doctor	0.2	0.4	1.2	0.6	-0.3	-0.8	-0.4	0.2	-1.1
Cholesterol lowering medication	2.1	3.0	11.5	-3.4	0.3	1.1	-1.1	2.1	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.6	-0.7	-0.5	-1.1	0.4	1.3	-0.8
Pain experienced in last month	0.1	0.2	0.7	0.3	0.3	0.9	-0.5	0.0	0.3
Supplements: Calcium	0.6	0.7	1.5	0.9	0.1	-0.4	0.5	-1.1	1.2
Basal cell carcinoma (self-reported)	0.7	0.8	2.0	-1.0	0.2	1.4	-1.3	0.2	-0.3
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.1	-0.0	-0.6	-1.1	0.4	-0.1	0.0
Deep venous thrombosis (DVT) (self-reported)	2.7	3.5	5.8	-2.3	1.3	1.0	-2.1	1.7	-2.4
Heart disease (siblings)	0.7	0.9	2.2	-1.5	0.2	1.3	-1.1	0.1	0.3
Alcohol drinker status: Previous	0.3	0.3	0.6	0.4	-0.8	-0.7	0.4	0.5	0.1
Pack years of smoking	1.3	1.9	3.3	-1.8	1.1	1.4	-1.2	0.5	-1.8
Impedance of whole body	0.2	0.8	2.3	0.1	0.1	-1.5	-0.1	1.5	0.7
Leg fat mass (left)	0.2	0.8	1.6	-0.1	1.1	-0.5	1.3	1.1	-0.6
Arm predicted mass (left)	0.6	3.0	10.7	-1.1	3.3	1.7	-0.6	1.5	-0.8