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chr2:72,774,203-74,654,861

Best TWAS P=6.53e-11 · Best GWAS P=3.72e-09 conditioned to 0.227

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ALMS1P	0.17	0.22	enet	18	0.23	1.6e-27	-5.0	-5.4	6.5e-08	0.79	0.27	0.73	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FBXO41	0.08	0.03	blup	281	0.03	1.5e-04	-4.8	-6.5	6.5e-11	0.40	0.32	0.66	TRUE
3	CommonMind	Brain Pre-frontal Cortex	NAT8	0.09	0.12	blup	348	0.13	6.4e-16	-5.9	-5.3	9.6e-08	0.89	0.02	0.98	FALSE
4	CommonMind	Brain Pre-frontal Cortex	TPRKB	0.07	0.09	lasso	3	0.10	9.7e-13	-5.7	5.4	7.3e-08	-0.89	0.07	0.93	FALSE
5	GTEx	Artery Tibial	TPRKB	0.11	0.11	lasso	3	0.13	4.5e-10	-4.8	5.6	2.5e-08	-0.86	0.44	0.56	FALSE
6	GTEx	Cells Transformed fibroblasts	ALMS1	0.10	0.05	lasso	1	0.03	5.1e-03	-5.5	-5.5	2.9e-08	0.97	0.04	0.86	FALSE
7	GTEx	Esophagus Mucosa	PRADC1	0.13	0.04	enet	10	0.05	2.1e-04	-5.2	5.1	3.1e-07	-0.26	0.29	0.60	FALSE
8	GTEx	Esophagus Muscularis	PRADC1	0.20	0.14	enet	11	0.10	1.7e-06	-4.7	5.5	3.4e-08	-0.23	0.29	0.71	FALSE
9	GTEx	Heart Left Ventricle	PRADC1	0.16	0.09	enet	14	0.11	1.7e-06	-5.4	5.4	8.6e-08	-0.21	0.28	0.70	FALSE
10	GTEx	Muscle Skeletal	PRADC1	0.09	0.03	lasso	3	0.06	3.0e-06	-4.7	5.3	1.1e-07	-0.30	0.33	0.66	FALSE
11	GTEx	Pancreas	ALMS1	0.12	0.12	lasso	1	0.06	1.3e-03	-5.5	-5.5	2.9e-08	0.97	0.05	0.88	FALSE
12	NTR	Blood	ALMS1	0.04	0.04	lasso	4	0.04	1.2e-12	-5.5	-5.2	2.1e-07	0.91	0.04	0.96	FALSE
13	YFS	Blood	ALMS1	0.07	0.09	lasso	14	0.09	3.4e-29	-5.0	-5.6	2.8e-08	0.89	0.33	0.66	FALSE
14	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ALMS1P	0.14	0.09	lasso	3	0.08	1.4e-07	-5.1	-5.6	2.5e-08	0.86	0.00	1.00	FALSE
15	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ALMS1P	0.16	0.10	enet	6	0.11	6.6e-06	-5.3	-5.7	1.6e-08	0.69	0.00	0.99	FALSE
16	The Cancer Genome Atlas	Colon Adenocarcinoma	ALMS1P	0.08	0.04	blup	42	0.05	5.3e-04	-5.1	-5.6	2.0e-08	0.84	0.01	0.98	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TPRKB	0.18	0.07	enet	6	0.09	5.8e-10	-4.4	5.5	4.9e-08	-0.75	0.05	0.92	TRUE
18	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ALMS1P	0.12	0.04	enet	7	0.06	2.6e-04	-5.1	-5.8	6.2e-09	0.87	0.01	0.93	FALSE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	ALMS1P	0.18	0.09	lasso	3	0.08	5.6e-09	-5.1	-5.2	1.8e-07	0.84	0.00	1.00	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	NAT8	0.05	0.01	blup	30	0.03	2.5e-04	-5.1	-5.5	4.9e-08	0.80	0.01	0.98	FALSE
21	The Cancer Genome Atlas	Lung Adenocarcinoma	ALMS1	0.04	0.03	blup	86	0.03	7.1e-05	-5.5	-5.2	2.2e-07	0.95	0.04	0.95	FALSE
22	The Cancer Genome Atlas	Lung Adenocarcinoma	ALMS1P	0.09	0.07	lasso	3	0.06	6.2e-08	-5.3	-5.3	1.0e-07	0.79	0.00	1.00	FALSE
23	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ALMS1	0.03	0.01	blup	86	0.02	6.5e-03	-5.5	-5.6	1.6e-08	0.93	0.05	0.88	FALSE
24	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ALMS1P	0.14	0.12	lasso	2	0.13	2.9e-14	-5.3	-5.2	1.9e-07	0.75	0.00	1.00	FALSE
25	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NAT8	0.04	0.05	lasso	1	0.04	9.2e-06	-5.3	-5.3	9.5e-08	0.79	0.00	0.99	FALSE
26	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ALMS1P	0.09	0.07	lasso	2	0.07	2.9e-05	-5.1	-5.1	2.9e-07	0.81	0.00	0.99	FALSE
27	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TPRKB	0.08	0.08	blup	30	0.09	7.8e-07	-4.4	5.3	1.5e-07	-0.78	0.02	0.95	FALSE
28	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ALMS1P	0.21	0.11	blup	42	0.13	9.1e-06	-5.3	-5.2	2.2e-07	0.70	0.00	0.99	FALSE
29	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TPRKB	0.22	0.12	blup	30	0.14	4.7e-06	-4.7	5.4	7.1e-08	-0.77	0.02	0.95	FALSE
30	The Cancer Genome Atlas	Soft Tissue Sarcoma	NAT8	0.07	0.06	blup	30	0.05	4.2e-04	-5.0	-5.2	1.6e-07	0.82	0.01	0.92	FALSE
31	The Cancer Genome Atlas	Stomach Adenocarcinoma	ALMS1	0.07	0.06	blup	92	0.04	5.7e-04	-5.9	-5.7	1.2e-08	0.98	0.01	0.97	FALSE