Hub : Genes

FBXO41

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0840	0.0350	1.1e-04	0.028	0.029	0.016	0.028	0.021	1.9e-04	1.5e-04	4.3e-03	2.1e-04	1.1e-03
2	GTEx	Cells EBV-transformed lymphocytes	0.4180	0.1290	3.8e-03	0.147	NA	0.012	NA	0.095	1.6e-05	NA	1.3e-01	NA	5.3e-04
3	GTEx	Nerve Tibial	0.0714	0.0383	7.3e-03	0.009	NA	0.036	NA	0.053	6.6e-02	NA	1.4e-03	NA	1.2e-04
4	METSIM	Adipose	0.1124	0.0387	3.3e-08	0.045	0.055	0.051	0.056	0.045	2.2e-07	1.0e-08	4.3e-08	9.2e-09	2.3e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.3	0.5	1.8	1.3	0.0	0.3	-0.0
Bipolar Disorder or Schizophrenia	1.3	3.3	7.6	2.8	-1.1	1.9	-0.8
Depressed Affect (Nagel 2018)	0.7	1.6	2.8	0.9	-1.1	-1.3	-1.7
Depression (Nagel 2018)	0.5	0.7	2.4	1.5	-0.6	0.4	-0.1
Intelligence (Savage-Jansen 2018)	4.6	14.3	42.7	-6.5	-0.1	-1.9	3.3
Neuroticism (Nagel 2018)	0.5	1.1	2.2	0.7	-0.5	-1.2	-1.5
Schizophrenia (2018)	1.7	3.4	6.1	2.5	-1.5	2.1	-0.9
Schizophrenia vs Biploar Disorder	0.9	1.2	2.0	1.3	1.1	1.4	0.3
Worry (Nagel 2018)	0.4	0.8	2.1	0.3	-0.3	-1.0	-1.4
Alzheimer’s Disease (in mother)	1.1	1.3	2.6	-1.3	0.2	0.9	1.6
Alzheimer’s Disease (in father)	0.5	0.5	1.0	-0.8	-0.5	-1.0	-0.3
Alzheimer’s Disease (including proxy)	0.2	0.2	0.4	-0.5	0.3	0.6	0.5
Crohns Disease (2017)	0.4	0.8	1.3	-0.9	0.7	-1.1	0.7
Irritable Bowel Disease (IBD)	0.5	1.1	2.3	0.2	1.5	0.3	1.4
Ulcerative Colitis (UC)	0.8	1.6	1.8	1.3	1.1	1.2	1.4
Major Depression (MDD)	1.5	1.9	2.7	1.6	-0.3	-1.5	-1.6
Reaction Time	0.2	0.4	1.2	1.1	-0.4	0.6	0.1
Verbal and Numeric Reasoning (VNR)	6.3	15.2	43.3	-6.6	-0.2	-2.6	3.2
Breast Cancer	0.4	0.9	2.0	-0.7	-1.0	-1.4	0.1
Ovarian Cancer	0.6	0.8	1.5	0.4	-1.2	1.0	0.6
Prostate Cancer	0.3	0.5	0.8	0.9	0.7	0.2	0.7
Age at First Birth	0.3	0.4	0.8	-0.9	-0.2	0.6	0.6
Bipolar Disorder (2011)	0.9	0.9	1.8	1.1	-1.4	0.0	-0.7
Body Mass Index (BMI) (2010)	0.5	0.7	1.2	-1.0	-0.6	1.1	0.6
Coronary Artery Disease (CAD)	1.5	1.8	3.7	1.9	1.4	0.4	1.2
Crohns Disease (2012)	0.4	0.6	1.2	-1.1	-0.7	-0.7	0.7
Mean Putamen Volume	1.1	1.3	3.4	-1.9	0.4	-0.8	0.9
Fasting Glucose	1.1	1.3	5.2	-0.2	-2.3	0.2	-0.0
HbA1C	0.0	0.0	0.0	0.1	0.0	0.1	-0.1
HDL Cholesterol	0.6	1.1	3.4	0.6	1.8	0.6	0.4
LDL Cholesterol	0.9	1.4	2.9	0.0	-1.2	-1.7	-1.2
Lupus	0.7	1.1	2.6	0.3	-1.6	0.3	-1.3
Neuroticism (2016)	0.5	0.8	1.7	0.4	-1.0	-1.3	-0.5
Primary Biliary Cirrhosis	0.9	1.3	2.3	-1.5	1.5	0.8	0.3
Rheumatoid Arthritis	0.1	0.2	0.5	-0.1	0.1	0.3	-0.7
Schizophrenia (2014)	1.7	3.8	6.9	2.6	-1.2	2.6	-0.3
Triglycerides	0.8	1.3	3.6	0.8	0.0	-0.9	-1.9
Type 2 Diabetes (T2D) (2012)	1.5	1.7	3.2	0.4	-1.8	-1.6	-1.1
Ulcerative Colitis	1.5	2.2	3.5	0.1	1.8	1.4	1.9
Blood Eosinophil Count	0.1	1.1	2.8	-0.1	0.1	1.3	1.7
Blood Platelet Count	0.1	1.0	2.6	1.1	0.4	1.6	0.0
Blood Red Count	0.1	0.5	0.7	0.6	-0.8	-0.8	0.6
Blood White Count	0.7	4.9	8.6	2.9	-1.6	-2.1	-2.0
Heel T-Score	0.1	0.9	1.8	0.9	-0.6	0.8	-1.3
BMI	0.3	1.8	5.4	0.3	-2.3	-1.3	-0.1
Height	0.3	5.2	6.8	-2.5	-1.6	-2.2	-2.6
Waist Hip Ratio (WHR)	0.0	0.2	0.3	-0.5	0.6	-0.0	-0.3
Systolic Blood Pressure	2.5	12.7	32.4	5.7	-0.9	-1.4	-4.0
Smoking Status	1.3	3.1	9.7	3.1	-1.4	-0.5	-0.7
Allergy or Eczema	0.4	1.2	2.6	-0.6	1.2	0.5	1.6
Cardiovascular Disease	3.1	10.4	26.8	5.2	-1.2	0.1	-3.6
Hypothyroidism (self reported)	0.1	0.3	0.7	-0.0	0.1	-0.6	0.8
Respiratory disease	0.7	1.6	3.9	2.0	1.4	-0.5	-0.4
Type 2 Diabetes (T2D) (2018)	2.2	4.1	13.0	-0.1	-3.6	-0.7	-1.6
Lung FEV1/FVC ratio	0.2	0.9	1.5	-0.7	-1.2	0.6	1.2
Lung FVC	0.2	0.9	1.5	0.7	-1.2	0.3	1.2
Neuroticism	0.1	0.3	0.7	0.8	-0.1	0.5	-0.5
Chronotype (morning person)	1.4	3.1	6.6	-1.4	-0.6	-1.9	-2.6
Hair Pigment	0.1	3.0	5.2	1.4	-1.3	-1.8	-2.3
Tanning	0.1	1.2	2.7	-0.4	-0.5	1.6	1.3
Hand grip strength (left)	0.3	0.7	2.1	0.2	-0.7	-0.3	-1.4
Number of treatments/medications taken	7.8	14.1	20.9	4.4	-3.7	-1.3	-4.6
Average weekly spirits intake	1.4	1.7	2.7	-1.6	-1.6	-1.2	0.3
Sensitivity / hurt feelings	0.4	0.7	2.7	1.6	0.4	0.2	0.0
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.6	1.3	0.2	0.8	0.5
Hearing difficulty/problems: Yes	0.5	0.7	2.0	1.4	0.0	-0.9	0.3
Relative age of first facial hair	0.4	0.9	2.4	-1.5	0.2	-0.2	1.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.9	-0.7	0.4	-0.2	0.9
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.8	0.5	0.1	-1.7	-0.4
Ever had hysterectomy (womb removed)	0.2	0.2	0.4	0.3	0.6	-0.7	-0.2
Systolic blood pressure, automated reading	2.3	6.8	19.8	4.4	-1.0	-0.8	-2.4
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	1.7	-1.2	-1.3	0.5	1.2
Angina	3.6	4.8	9.1	3.0	-2.2	-0.3	-2.2
Medication for hormone replacement therapy	0.2	0.3	0.6	-0.4	0.6	-0.7	0.2
Vitamin and mineral supplements	0.8	1.1	1.9	-1.4	0.9	-1.2	0.3
Supplements: Zinc	0.6	0.6	1.5	-0.8	-0.1	0.7	1.2
Medication: Co-codamol	2.9	3.4	5.4	1.7	-1.4	-1.8	-2.3
Medication: Metformin	2.5	3.5	9.6	-1.5	-3.1	-0.8	-1.1
Diabetes (father)	0.3	0.4	1.1	0.7	0.2	-0.2	-1.0
Diabetes (mother)	0.4	0.5	1.0	0.8	0.2	-0.4	-1.0
Severe depression (siblings)	0.8	0.8	2.8	1.7	0.7	0.3	-0.1
Pack years adult smoking proportion	1.6	2.5	7.2	0.5	-2.7	-1.4	-0.7
Impedance of leg (right)	0.2	1.1	2.2	1.5	0.4	0.1	-1.5
Leg fat-free mass (left)	0.7	3.8	9.1	-1.8	-3.0	-1.6	-0.3
Trunk fat percentage	1.1	4.6	10.7	1.0	-3.3	-2.0	-1.6
Hand grip strength (right)	0.2	0.6	1.8	0.4	0.5	0.0	-1.4
Townsend deprivation index at recruitment	0.5	0.7	1.7	0.4	-1.3	-0.3	1.0
Current tobacco smoking	0.4	0.7	2.0	1.4	-0.6	-0.2	0.7
Average weekly fortified wine intake	1.5	1.7	4.6	-2.1	-0.3	-1.5	-0.1
Maternal smoking around birth	0.3	0.4	0.9	-0.2	0.2	-1.0	-0.9
Fed-up feelings	0.5	1.0	1.8	1.3	-0.4	-0.7	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.9	1.4	-0.6	0.2	-0.1
Relative age voice broke	1.1	1.7	5.4	0.1	2.3	1.2	-0.2
Taking other prescription medications	4.6	7.1	13.7	2.3	-2.6	-1.6	-3.7
Age when periods started (menarche)	1.0	2.5	5.8	-1.5	-2.4	-1.2	-0.5
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	0.0	-0.1	0.5	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.3	0.8	0.7	-0.2	0.1	-0.9
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	6.3	-2.5	0.2	0.4	0.6
Qualifications: CSEs or equivalent	2.1	2.8	9.5	1.3	0.1	3.1	-0.0
Serious illness, injury or assault to yourself	3.6	4.4	8.0	2.1	-2.8	-0.9	-2.1
High blood pressure	2.8	7.7	19.3	4.4	-1.6	-0.4	-2.9
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.9	0.1	1.2	0.1	1.4
Multivitamins +/- minerals	0.3	0.4	0.9	0.7	-0.9	0.2	-0.3
Stomach or abdominal pain in last month	1.8	2.3	5.3	1.6	-0.7	-0.9	-2.3
Supplements: Glucosamine	0.3	0.4	0.7	0.7	-0.6	0.4	-0.8
Diverticular disease/diverticulitis (self-reported)	1.9	2.2	4.8	0.2	2.2	0.9	1.8
Medication: Atenolol	3.3	4.2	13.5	3.7	-0.8	0.1	-1.6
Medication: Levothyroxine sodium	0.5	0.9	2.6	-0.6	-0.6	-1.6	0.6
Sitting height	0.1	0.8	2.8	-0.2	-1.7	0.6	-0.1
Chronic bronchitis/emphysema (father)	1.0	1.2	3.2	1.8	0.1	0.6	-1.1
High blood pressure (mother)	0.7	1.0	1.6	1.3	-0.4	-1.2	-1.0
Body mass index (BMI)	0.6	2.7	7.6	0.8	-2.8	-1.6	-0.5
Impedance of leg (left)	0.3	1.2	2.7	1.6	0.7	0.8	-1.0
Leg predicted mass (left)	0.8	4.0	9.6	-1.8	-3.1	-1.7	-0.4
Trunk fat mass	1.2	5.0	12.7	0.4	-3.6	-2.2	-1.4
Waist circumference	0.5	2.0	5.8	0.8	-2.4	-1.1	-0.5
Number of incorrect matches in round	4.3	7.1	13.1	3.6	-1.7	-0.7	-3.4
Past tobacco smoking	0.7	1.2	3.9	-2.0	0.5	0.2	0.8
Alcohol usually taken with meals	0.9	1.5	3.9	-1.3	2.0	-0.5	-0.0
Nervous feelings	0.1	0.3	0.9	-0.2	-0.0	-1.0	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.5	0.6	0.7	0.2	-0.4
Hearing difficulty/problems with background noise	0.2	0.4	1.1	0.1	0.4	0.3	1.1
Hair/balding pattern: Pattern 2	0.7	0.9	2.6	0.5	-0.7	-0.5	-1.6
Had menopause	1.2	1.5	3.0	0.4	-1.1	-1.7	-1.4
Had other major operations	0.6	0.7	2.1	0.2	0.5	0.7	1.5
Forced vital capacity (FVC)	0.7	2.7	5.8	-2.4	-1.6	-0.9	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	2.0	0.6	-0.9	0.1	-1.4
Ever unenthusiastic/disinterested for a whole week	1.3	1.5	2.8	1.7	-0.4	-0.9	-1.6
Qualifications: None of the above	1.5	3.3	8.1	2.9	-2.2	0.1	-0.2
Financial difficulties in last 2 years	2.1	2.9	6.7	-0.7	-2.6	-2.0	0.5
Mouth/teeth dental problems	0.2	0.4	0.9	-0.9	0.7	0.2	-0.1
Heart attack	4.1	5.2	9.8	2.1	-3.1	-0.6	-2.5
Allergy	0.3	0.7	0.8	-0.7	-0.9	0.8	-0.9
Pain all over the body in last month	0.9	1.0	2.5	0.8	1.6	-0.1	0.8
Diabetes (self-reported)	2.6	4.1	11.1	-1.2	-3.3	-1.2	-1.5
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	2.6	1.4	-0.2	-1.6	-1.1
Medication: Ramipril	4.7	6.1	8.7	2.9	-2.7	-0.1	-3.0
Medication: Simvastatin	1.0	1.4	3.9	1.1	-0.8	-0.1	-2.0
Fluid intelligence score	5.8	12.1	34.7	-5.9	-0.9	-3.0	1.9
Illnesses of siblings	1.0	1.4	2.6	-1.5	-0.2	1.6	0.9
Neuroticism score	0.2	0.4	1.4	1.2	-0.5	-0.3	-0.1
Weight	0.7	3.6	10.8	-0.3	-3.3	-1.7	-0.8
Impedance of arm (right)	0.1	0.6	1.6	0.8	-0.1	-0.6	-1.3
Arm fat percentage (right)	1.2	4.7	11.9	1.2	-3.5	-2.1	-1.1
Trunk fat-free mass	0.5	2.6	7.0	-1.7	-2.6	-0.7	-0.3
Hip circumference	0.6	2.6	7.4	-0.2	-2.7	-1.7	0.2
Time employed in main current job	0.3	0.4	1.1	-1.1	-0.5	-0.4	-0.0
Alcohol intake versus 10 years previously	0.2	0.2	0.4	0.4	0.5	0.3	-0.6
Father’s age at death	2.2	2.9	6.7	-2.6	0.6	0.3	2.1
Worrier / anxious feelings	0.5	1.0	1.9	1.4	0.6	-0.4	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	4.4	2.1	-0.1	-0.2	-0.6
Falls in the last year	2.5	3.3	4.5	1.1	-2.1	-1.9	-2.0
Hair/balding pattern: Pattern 3	0.2	0.3	0.5	0.7	-0.4	0.3	0.6
Number of live births	0.3	0.4	0.7	0.3	0.8	-0.8	-0.2
Forced expiratory volume in 1-second (FEV1)	1.0	3.5	8.8	-3.0	-1.0	-0.6	2.0
Pulse rate	1.2	2.0	2.7	1.7	-1.2	-1.1	-1.6
Happiness	0.2	0.2	0.5	0.4	-0.1	-0.7	-0.6
Noisy workplace	0.6	0.8	2.1	1.4	-0.3	0.6	0.7
Qualifications: A levels/AS levels or equivalent	3.4	7.4	21.1	-4.6	1.0	0.3	2.7
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.1	-1.8	0.7	-0.6	0.1
Mouth/teeth dental problems: Dentures	0.9	1.6	5.3	2.3	-0.6	0.4	-0.6
Asthma	0.2	0.3	0.6	0.7	0.8	-0.5	-0.0
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.7	-0.8	0.4	0.1	0.0
Medication: Cholesterol lowering	5.9	9.1	16.2	2.3	-4.0	-1.8	-3.4
Depression (self-reported)	3.1	3.8	8.2	2.9	0.1	-0.4	-2.6
Medication: Lansoprazole	1.6	1.8	4.3	2.1	-0.7	0.8	-1.3
Prospective memory result	2.1	2.5	3.7	1.8	-1.7	-0.2	-1.9
Lung cancer (father)	0.2	0.2	0.6	0.3	-0.7	0.3	-0.2
Illnesses of mother	0.6	0.8	1.5	-1.2	0.8	0.0	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	6.2	-2.5	-0.9	-0.4	2.1
Pulse wave Arterial Stiffness index	1.8	2.1	4.3	0.2	-1.9	-0.4	-2.1
Impedance of arm (left)	0.0	0.2	0.3	0.4	0.5	0.2	-0.4
Arm fat mass (right)	1.0	4.2	11.4	0.3	-3.4	-2.1	-0.8
Trunk predicted mass	0.5	2.8	7.6	-1.8	-2.8	-0.7	-0.3
Standing height	0.3	2.7	4.7	-2.2	-1.8	-1.0	-1.4
Length of working week for main job	0.7	0.7	2.0	-0.3	-0.9	-1.4	-0.2
Exposure to tobacco smoke at home	2.0	2.3	6.8	2.6	-1.1	1.0	-0.1
Breastfed as a baby	1.4	1.7	4.1	-1.2	1.1	0.5	2.0
Tense / ‘highly strung’	0.9	1.6	3.6	1.0	-1.1	-1.9	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	2.9	4.5	8.0	2.8	-1.0	-1.0	-2.8
Hair/balding pattern: Pattern 4	0.2	0.5	0.9	-1.0	0.6	-0.5	-0.8
Birth weight of first child	2.0	3.6	7.2	-2.5	-0.3	-2.7	0.7
Peak expiratory flow (PEF)	0.3	0.6	1.6	-1.3	0.6	0.1	0.7
Pulse wave reflection index	0.7	0.8	1.9	-0.1	-1.1	0.3	-1.4
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.3	1.2	0.7	-0.2	-0.3
Loud music exposure frequency	2.4	2.6	4.3	-2.1	0.6	-1.4	1.9
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	4.5	-2.1	-1.2	-0.7	-1.5
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.3	-1.1	-0.8	-0.2	1.1
Blood clot in the leg (DVT)	0.3	0.4	0.6	-0.8	-0.5	-0.8	-0.3
Medication: Paracetamol	0.2	0.4	0.8	0.4	0.9	-0.6	0.3
Headache pain in last month	0.8	1.5	2.7	-1.5	1.6	-0.2	0.9
Medication for cholesterol, blood pressure or diabetes	5.9	9.7	14.5	-3.8	3.2	1.1	3.6
Glaucoma (self-reported)	2.6	3.1	5.8	-0.3	1.4	2.1	2.4
Gout (self-reported)	1.1	1.6	3.8	0.7	-1.9	-1.3	-0.5
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.5	-0.6	0.3	-1.2	1.0
Medication: Amlodipine	2.1	3.0	5.4	2.3	-0.9	-1.3	-2.0
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.9	1.4	0.6	1.7	-0.1
Birth weight	0.2	0.5	0.9	-0.5	0.5	-0.7	-1.0
Chronic bronchitis/emphysema (mother)	2.0	2.3	5.9	2.4	-1.3	1.1	-0.7
High blood pressure (siblings)	1.5	2.1	4.0	1.6	0.3	-2.0	-1.4
Forced vital capacity (FVC), Best measure	0.6	2.1	4.2	-2.0	-1.3	-0.5	1.5
Body fat percentage	1.2	4.6	10.0	1.2	-3.2	-2.1	-1.5
Leg fat percentage (right)	1.1	4.1	8.9	1.8	-3.0	-1.6	-1.3
Arm fat-free mass (right)	0.5	2.4	6.0	-1.7	-2.5	-0.8	0.0
Exposure to tobacco smoke outside home	0.8	1.1	4.0	0.3	-2.0	-0.6	0.1
Comparative body size at age 10	1.9	5.2	10.9	-1.7	2.5	-0.8	3.3
Number of full brothers	0.6	0.7	2.3	0.3	1.5	-0.2	-0.7
Worry too long after embarrassment	0.2	0.4	1.4	-0.1	-0.3	-1.2	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	4.4	5.7	10.7	2.2	-2.2	-1.5	-3.3
Wheeze or whistling in the chest in last year	0.3	0.6	1.9	1.4	0.2	0.3	-0.7
Number of children fathered	2.3	2.6	6.4	-0.8	-0.4	-2.5	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	2.1	2.4	4.5	2.1	-0.5	1.2	-1.8
Age at first live birth	1.0	1.7	4.5	-2.1	1.0	1.1	0.1
Pulse wave peak to peak time	1.6	1.9	4.2	-0.4	1.8	0.4	2.0
Health satisfaction	0.7	0.9	2.8	1.7	-0.5	0.3	-0.7
Shortness of breath walking on level ground	1.0	1.2	2.6	0.3	0.5	1.3	1.6
Qualifications: College or University degree	3.5	11.0	26.5	-5.1	3.0	-0.2	2.9
Eye problems/disorders: None of the above	4.3	4.9	8.1	0.9	-2.2	-2.5	-2.9
Mouth/teeth dental problems: Loose teeth	1.0	1.2	3.0	-0.6	1.1	-0.3	1.7
Emphysema/chronic bronchitis	0.4	0.5	1.2	1.1	0.7	-0.4	-0.1
Medication for pain relief, constipation, heartburn	1.1	2.0	4.5	-1.1	1.5	0.2	2.1
Neck or shoulder pain in last month	1.0	1.5	2.8	0.3	1.4	1.0	1.7
Medication: Blood pressure	7.8	13.7	21.5	4.6	-3.6	-1.2	-4.3
Angina (self-reported)	3.1	4.1	8.6	2.9	-1.9	-0.3	-2.0
Migraine (self-reported)	0.4	0.5	0.6	-0.7	-0.8	-0.7	0.8
Medication: Ibuprofen	0.2	0.2	0.7	-0.3	-0.2	-0.8	-0.4
Medication: Allopurinol	1.9	2.6	3.5	1.4	-1.4	-1.9	-1.7
Medication: Omeprazole	2.9	3.5	7.4	1.8	0.1	-1.9	-2.7
Medication: Seretide 50 evohaler	0.2	0.3	0.6	0.8	0.0	0.4	-0.6
Mean time to correctly identify matches	0.5	0.9	2.2	1.5	-1.1	0.0	-0.4
Heart disease (mother)	0.1	0.1	0.3	-0.6	-0.0	0.0	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.5	1.3	0.1	0.7	0.7	1.1
Whole body fat mass	1.2	4.9	12.6	0.7	-3.5	-2.1	-1.5
Leg fat mass (right)	1.1	4.1	10.3	1.1	-3.2	-1.8	-1.3
Arm predicted mass (right)	0.5	2.4	7.0	-1.5	-2.6	-0.7	-0.1
Pulse rate, automated reading	2.1	6.9	10.2	2.9	-3.2	-0.7	-2.9
Alcohol intake frequency.	0.1	0.3	0.9	0.3	0.0	-0.9	-0.4
Comparative height size at age 10	0.3	1.4	3.2	-0.1	-1.4	-0.5	-1.8
Number of full sisters	0.6	0.7	2.1	-0.3	-1.5	-0.6	0.6
Suffer from ‘nerves’	0.2	0.4	0.7	0.1	-0.9	-0.6	-0.6
Overall health rating	1.7	3.6	9.2	3.0	-1.6	-1.1	-1.2
Chest pain or discomfort	0.7	1.0	2.9	1.7	0.2	1.1	0.0
Had major operations	0.5	0.6	1.3	-0.1	0.3	1.2	0.9
Age at last live birth	1.4	2.1	5.8	-2.4	0.8	0.5	1.2
Family relationship satisfaction	0.4	0.5	1.1	-0.6	-1.0	-0.6	0.3
Leg pain on walking	1.0	1.2	3.0	0.6	0.6	1.7	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.5	-0.4	1.0	0.8	1.2
Commuting to job workplace: Car/motor vehicle	1.3	1.5	4.3	1.2	-0.2	0.1	-2.1
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	4.2	0.2	2.0	1.3	0.3
Medication: Aspirin	3.2	4.2	10.0	0.7	-3.2	1.7	-1.8
Supplements: Vitamin C	0.5	0.6	2.4	0.3	0.0	1.6	0.3
Knee pain experienced in last month	0.3	0.5	1.5	-0.7	-1.2	-0.2	-0.2
Hypertension (Self-reported)	2.8	7.9	18.7	4.3	-1.6	-1.0	-3.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	3.9	1.9	0.1	-0.2	-2.0
Illnesses of father: Heart disease	1.0	1.4	3.9	1.1	0.5	0.5	-2.0
Illnesses of siblings: Diabetes	0.2	0.3	0.8	-0.6	0.0	-0.1	0.9
Smoking status: Previous	0.6	0.9	2.9	1.7	-0.2	-0.3	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.7	-1.6	0.1	0.2	0.8
Whole body fat-free mass	0.6	3.4	8.8	-1.8	-3.0	-1.1	-0.4
Leg fat-free mass (right)	0.7	3.7	9.4	-1.8	-3.1	-1.3	-0.3
Arm fat percentage (left)	1.0	3.9	10.0	1.0	-3.2	-2.0	-0.8
Average weekly red wine intake	2.1	3.1	4.8	-2.2	2.1	1.0	1.4
Handedness (chirality/laterality): Left-handed	0.8	0.9	3.0	-0.0	0.1	0.8	1.7
Mood swings	1.4	2.5	3.6	1.7	-1.9	-0.9	-1.7
Loneliness, isolation	1.2	1.7	5.8	-0.7	-2.4	-0.7	0.3
Long-standing illness, disability or infirmity	1.6	2.5	5.0	0.9	-2.2	-1.4	-1.4
Ever had bowel cancer screening	1.0	1.2	2.3	1.2	0.3	-1.0	-1.5
Diabetes diagnosed by doctor	3.4	5.5	15.3	-2.0	-3.9	-1.2	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.9	-0.5	0.8	-0.1	1.0
Friendships satisfaction	2.2	2.8	8.0	-2.8	0.4	0.3	1.7
Qualifications: nursing, teaching	2.3	3.5	7.4	-2.6	2.7	-0.2	-0.2
Commuting to job workplace: Walk	1.1	1.2	2.2	-1.3	-0.5	0.6	1.5
Eye problems/disorders: Cataract	3.1	3.6	6.8	-0.2	2.4	2.6	1.3
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	4.1	-0.2	2.0	0.9	1.4
Medication for cholesterol	0.3	0.5	1.0	-0.8	-0.5	-1.0	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.9	0.4	-0.4	-0.9	0.5
Back pain experienced in last month	2.4	3.4	10.9	3.3	-0.5	0.9	-1.3
Mineral and other dietary supplements	2.0	2.6	5.7	-2.4	1.3	-1.3	1.2
Breast cancer (self-reported)	0.1	0.1	0.3	0.5	-0.2	-0.5	-0.1
Asthma (self-reported)	0.2	0.3	0.6	0.8	0.3	-0.7	-0.3
Osteoporosis (self-reported)	0.1	0.1	0.3	-0.6	-0.0	-0.2	0.5
Osteoarthritis (self-reported)	0.6	0.8	2.3	1.5	-0.0	-0.7	-0.7
Medication: Aspirin	3.0	4.0	9.0	1.0	-3.0	1.8	-1.6
Medication: Gliclazide	1.9	2.1	5.1	1.0	-2.2	0.1	-1.6
Illnesses of father: None of the above (group 1)	2.3	2.8	6.5	-2.5	0.3	-0.5	2.1
Smoking status: Current	0.4	0.7	1.9	1.4	-0.6	-0.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	3.9	9.6	-2.2	-0.4	0.9	3.1
Whole body water mass	0.5	3.1	7.8	-1.9	-2.8	-1.1	-0.3
Leg predicted mass (right)	0.7	3.6	9.2	-1.9	-3.0	-1.3	-0.2
Arm fat mass (left)	1.0	4.1	11.8	0.2	-3.4	-2.0	-0.7
Number of self-reported non-cancer illnesses	8.0	13.8	25.0	5.0	-2.7	-2.0	-4.3
Average weekly champagne plus white wine intake	3.1	4.2	9.1	-1.0	3.0	1.7	2.0
Miserableness	0.1	0.2	0.6	-0.0	0.8	0.1	-0.3
Guilty feelings	0.8	1.2	3.1	0.8	0.6	1.8	0.8
Wears glasses or contact lenses	0.6	0.7	1.8	-0.2	0.3	-1.3	-0.9
Ever taken oral contraceptive pill	0.5	0.5	1.5	-1.2	-0.5	-0.1	0.5
Hearing aid user	0.2	0.3	0.7	0.0	0.2	0.6	0.8
Mother’s age at death	0.3	0.3	0.6	-0.3	0.8	-0.7	-0.4
Financial situation satisfaction	0.3	0.4	1.0	0.5	0.5	0.2	1.0
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.8	0.5	0.9	0.6	1.4
Commuting to job workplace: Public transport	4.2	5.0	11.7	-1.8	2.0	1.1	3.4
Eye problems/disorders: Glaucoma	1.9	2.2	5.7	-0.4	0.6	1.7	2.4
Medication: Blood pressure	0.7	1.3	2.4	1.5	-0.8	0.2	-1.5
Pain type(s) experienced in last month: Hip pain	3.6	4.6	8.0	1.5	-2.5	-1.4	-2.8
Supplements: Fish oil (including cod liver oil)	3.2	4.2	8.3	2.1	-2.9	1.1	-1.7
High cholesterol (Self-reported)	0.7	1.3	2.4	1.6	-0.5	0.4	-1.5
Medication: Bendroflumethiazide	0.8	1.1	2.3	1.5	-1.0	1.1	-0.0
Medication: Paracetamol	0.2	0.3	0.7	0.6	-0.0	-0.8	-0.0
Medication: Lisinopril	5.0	6.5	10.0	1.0	-2.9	-3.2	-2.5
Medication: Atorvastatin	3.5	4.4	10.1	1.0	-3.2	-1.4	-2.1
Illnesses of father: High blood pressure	0.1	0.2	0.5	0.1	-0.3	0.7	0.3
Alcohol drinker status: Never	0.0	0.0	0.1	0.3	0.2	0.1	-0.0
Ever smoked	0.7	1.3	3.0	1.7	-0.5	0.1	-1.3
Basal metabolic rate	0.6	3.5	9.7	-1.5	-3.1	-1.2	-0.4
Leg fat percentage (left)	1.0	3.7	7.7	2.0	-2.8	-1.1	-1.2
Arm fat-free mass (left)	0.6	3.0	7.8	-1.7	-2.8	-1.1	-0.1
Number of operations (self-reported)	0.5	0.7	1.9	1.4	0.5	0.8	-0.5
Average weekly beer plus cider intake	0.3	0.5	0.9	-0.2	-0.5	0.9	0.8
Irritability	0.1	0.2	0.8	0.1	-0.9	-0.3	-0.1
Risk taking	0.5	0.8	1.4	-0.9	0.4	0.9	1.2
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.8	-0.7	1.4	0.8	0.7
Fractured/broken bones in last 5 years	1.2	1.6	4.2	-0.4	-2.1	-1.3	-0.5
Age started oral contraceptive pill	0.3	0.4	1.5	0.3	0.4	1.2	0.2
Diastolic blood pressure, automated reading	2.3	7.1	21.0	4.6	-2.3	0.3	-1.4
Ever depressed for a whole week	1.6	2.0	3.6	1.5	-0.8	-1.2	-1.9
Unable to work because of sickness or disability	3.9	5.1	15.7	4.0	-1.2	-0.6	-1.7
Commuting to job workplace: Cycle	1.1	1.3	2.9	-1.7	0.1	-1.3	0.8
Myopia	1.3	1.9	4.2	-2.1	-0.4	-1.7	0.3
Vascular/heart problems diagnosed by doctor	3.4	9.4	22.0	-4.7	1.9	0.2	3.4
Cholesterol lowering medication	1.4	2.1	7.5	0.2	1.0	2.7	0.1
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	5.8	1.2	-0.0	-1.3	-2.4
Pain experienced in last month	0.3	0.4	1.0	-0.1	-0.7	-0.5	-1.0
Supplements: Calcium	0.9	1.0	4.0	-0.0	2.0	-0.1	-0.0
Basal cell carcinoma (self-reported)	0.5	0.6	1.3	1.2	0.6	0.1	-0.9
Heart attack/myocardial infarction (self-reported)	3.2	4.1	6.6	2.0	-2.6	-0.5	-2.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.2	-1.1	-0.5	-1.0	-0.1
Heart disease (siblings)	0.1	0.1	0.2	0.4	0.0	0.3	0.1
Alcohol drinker status: Previous	0.1	0.1	0.2	0.1	0.2	-0.3	0.4
Pack years of smoking	1.8	2.6	7.2	0.4	-2.7	-1.6	-0.8
Impedance of whole body	0.1	0.6	1.1	1.1	0.5	0.1	-0.9
Leg fat mass (left)	1.0	3.9	10.4	1.0	-3.2	-1.6	-1.3
Arm predicted mass (left)	0.5	2.6	7.8	-1.3	-2.8	-0.9	-0.3