TWAS hub - ALMS1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0790	0.0290	7.2e-06	0.030	0.047	0.056	0.049	0.068	1.4e-04	2.0e-06	2.4e-07	1.2e-06	1.2e-08
2	GTEx	Cells EBV-transformed lymphocytes	0.3330	0.0910	6.1e-05	0.167	NA	0.185	NA	0.187	4.1e-06	NA	1.2e-06	NA	1.0e-06
3	GTEx	Cells Transformed fibroblasts	0.0990	0.0410	3.4e-03	0.054	NA	0.001	NA	0.025	6.3e-05	NA	2.9e-01	NA	5.1e-03
4	GTEx	Esophagus Mucosa	0.0620	0.0340	6.9e-03	0.033	NA	0.006	NA	0.036	2.6e-03	NA	1.2e-01	NA	1.8e-03
5	GTEx	Muscle Skeletal	0.1127	0.0457	1.4e-03	0.023	NA	0.064	NA	0.040	2.4e-03	NA	6.7e-07	NA	7.4e-05
6	GTEx	Pancreas	0.1150	0.0520	1.7e-03	0.121	NA	0.004	NA	0.062	8.9e-06	NA	2.0e-01	NA	1.3e-03
7	NTR	Blood	0.0406	0.0129	7.5e-11	0.037	0.037	0.037	0.038	0.039	4.1e-12	3.6e-12	3.8e-12	2.5e-12	1.2e-12
8	YFS	Blood	0.0672	0.0159	0.0e+00	0.095	0.093	0.093	0.093	0.094	2.1e-29	8.9e-29	1.1e-28	5.9e-29	3.4e-29
9	TCGA	Colon Adenocarcinoma	0.0430	0.0290	2.6e-03	0.043	0.032	0.030	NA	0.039	1.7e-03	6.1e-03	7.4e-03	NA	2.5e-03
10	TCGA	Lung Adenocarcinoma	0.0353	0.0243	1.1e-04	0.030	0.034	0.025	NA	0.030	1.7e-04	7.1e-05	5.9e-04	NA	1.5e-04
11	TCGA	Lung Squamous Cell Carcinoma	0.0283	0.0228	7.3e-04	0.013	0.015	0.008	NA	0.014	1.2e-02	6.5e-03	3.7e-02	NA	9.1e-03
12	TCGA	Stomach Adenocarcinoma	0.0670	0.0460	5.5e-04	0.060	0.041	0.034	NA	0.038	3.8e-05	5.7e-04	1.6e-03	NA	9.5e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Prospective memory result	11.2	13.7	19.8	3.4	3.3	4.1	2.7	2.3	4.1	3.7	3.8	3.9	3.9	4.1	4.5
Verbal and Numeric Reasoning (VNR)	8.9	21.3	27.8	-4.7	-4.3	-5.0	-2.8	-4.4	-5.0	-4.5	-5.2	-4.2	-4.4	-5.2	-5.3
Intelligence (Savage-Jansen 2018)	8.6	26.4	32.5	-4.6	-5.1	-5.5	-4.1	-4.2	-5.5	-5.2	-5.6	-5.0	-5.2	-5.6	-5.7
Bipolar Disorder or Schizophrenia	7.9	19.3	24.3	4.9	4.6	4.7	2.6	4.5	4.7	3.9	4.9	4.1	4.0	4.8	4.7
Qualifications: A levels/AS levels or equivalent	7.5	16.5	21.9	-3.5	-4.1	-4.1	-4.1	-2.5	-4.1	-3.9	-4.7	-4.3	-4.3	-4.7	-3.9
Fluid intelligence score	7.4	15.4	21.7	-4.2	-3.4	-4.2	-2.3	-3.8	-4.2	-4.0	-4.3	-3.4	-3.7	-4.3	-4.7
Qualifications: nursing, teaching	7.3	11.3	16.3	-3.4	-3.4	-3.4	-2.9	-2.2	-3.4	-3.0	-4.0	-3.3	-3.4	-4.0	-3.6
Schizophrenia (2014)	6.9	15.3	20.5	4.4	4.3	4.0	2.5	3.8	4.0	3.1	4.5	3.6	3.5	4.4	4.3
Qualifications: O levels/GCSEs or equivalent	6.5	10.3	15.7	-2.9	-3.7	-3.0	-2.6	-2.4	-3.0	-3.4	-4.0	-3.0	-3.2	-3.8	-3.1
Diastolic blood pressure, automated reading	6.5	20.0	26.0	3.7	4.8	4.8	3.3	2.7	4.8	4.3	5.1	4.9	4.9	5.1	4.7
Schizophrenia (2018)	6.3	13.0	17.5	4.2	4.2	3.8	1.9	3.7	3.8	3.0	4.1	3.3	3.1	3.9	3.7
Coronary Artery Disease (CAD)	5.7	6.8	13.3	1.9	3.6	2.3	2.4	2.2	2.3	2.8	2.9	2.7	2.7	2.8	2.1
Qualifications: College or University degree	5.7	18.1	25.5	-3.7	-3.8	-4.4	-3.8	-2.2	-4.4	-4.0	-4.7	-4.6	-4.8	-5.0	-4.8
Illnesses of father: Heart disease	5.3	7.3	9.8	-2.4	-3.0	-2.8	-1.1	-2.1	-2.8	-2.8	-3.0	-2.8	-2.9	-3.1	-2.8
Qualifications: None of the above	5.0	10.7	15.7	3.4	3.4	3.4	1.5	2.9	3.4	2.9	3.9	3.2	3.4	4.0	3.4
Number of incorrect matches in round	4.9	8.1	13.0	1.8	2.4	3.0	2.0	1.9	3.0	2.6	3.0	3.2	3.4	3.4	3.6
Bipolar Disorder (2018)	4.1	6.5	8.5	2.7	2.6	2.7	1.7	2.2	2.7	2.5	2.7	2.4	2.5	2.8	2.9
Ever depressed for a whole week	4.0	5.0	9.7	1.7	1.7	2.5	3.1	0.9	2.5	2.3	2.0	2.4	2.4	2.1	2.5
Smoking Status	3.7	8.9	12.6	3.3	2.5	3.2	1.4	3.2	3.2	3.1	3.2	2.7	2.8	3.2	3.6
Age at first live birth	3.6	6.5	9.4	-1.6	-2.5	-2.7	-1.7	-1.1	-2.7	-2.8	-2.9	-2.8	-3.0	-3.1	-2.7
Average weekly red wine intake	3.6	5.3	8.3	-1.8	-2.2	-2.6	-1.9	-1.7	-2.6	-2.0	-2.1	-2.9	-2.8	-2.3	-2.3
Angina	3.4	4.4	6.5	2.1	1.8	2.2	2.6	1.0	2.2	2.0	2.1	2.2	2.2	2.3	2.3
Overall health rating	3.4	7.4	9.8	2.1	2.6	3.1	2.9	1.4	3.1	2.7	2.6	3.1	3.0	2.7	2.7
Angina (self-reported)	3.2	4.2	5.8	2.0	1.9	2.1	2.4	1.1	2.1	2.0	2.1	2.1	2.1	2.3	2.1
Depression (Nagel 2018)	3.1	4.6	7.9	2.2	1.6	2.3	1.2	2.1	2.3	2.0	2.3	2.0	2.2	2.3	2.8
Medication: Metformin	3.1	4.4	8.5	-2.6	-2.9	-1.9	-0.7	-1.9	-1.9	-2.2	-2.7	-1.5	-1.6	-2.3	-2.0
Falls in the last year	3.1	4.3	8.5	-0.0	1.5	2.3	2.7	-0.8	2.3	2.0	1.6	2.9	2.8	1.9	2.1
Alzheimer’s Disease (in mother)	3.0	3.5	5.8	-1.1	-1.1	-2.0	-2.3	0.2	-2.0	-2.1	-1.9	-1.9	-2.1	-2.1	-2.4
Reason for reducing amount of alcohol drunk: Health precaution	3.0	3.6	5.7	2.0	2.3	1.6	1.7	0.9	1.6	1.8	2.4	2.0	1.9	2.2	1.6
Townsend deprivation index at recruitment	2.8	3.9	5.7	2.0	1.6	2.0	2.0	1.2	2.0	1.9	2.2	1.9	2.0	2.4	2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.8	3.2	5.0	-1.2	-1.6	-2.0	-1.2	-1.1	-2.0	-1.7	-1.8	-2.2	-2.2	-1.9	-1.9
Prostate Cancer	2.5	3.5	6.1	1.7	2.4	1.9	1.0	1.0	1.9	1.5	2.5	1.7	1.9	2.3	2.1
Worry too long after embarrassment	2.5	4.2	5.5	-2.2	-2.3	-2.1	-1.8	-0.7	-2.1	-2.0	-2.3	-1.9	-2.2	-2.3	-2.2
Back pain experienced in last month	2.5	3.6	6.0	1.7	2.4	1.8	0.9	1.3	1.8	2.1	2.4	1.7	1.8	2.2	2.0
Vascular/heart problems diagnosed by doctor	2.5	6.8	9.2	-1.7	-2.7	-3.0	-1.7	-1.2	-3.0	-2.8	-2.9	-3.0	-2.8	-2.9	-2.6
High blood pressure	2.4	6.6	9.6	1.2	2.8	3.1	1.7	1.1	3.1	2.7	2.8	3.1	2.9	2.7	2.5
Leg fat percentage (left)	2.3	8.1	11.6	1.7	2.9	2.8	3.3	0.3	2.8	2.9	3.2	3.4	3.4	3.4	2.7
Hypertension (Self-reported)	2.2	6.2	9.7	0.8	2.7	3.0	1.7	0.7	3.0	2.7	2.7	3.1	2.9	2.7	2.3
Pack years adult smoking proportion	2.1	3.2	7.7	1.5	0.6	2.2	1.8	0.4	2.2	1.2	1.2	2.1	2.1	1.8	2.8
Trunk fat percentage	2.1	8.3	13.3	1.5	2.7	3.0	3.6	0.3	3.0	2.9	2.8	3.6	3.5	3.2	2.6
Chronotype (morning person)	2.0	4.7	8.2	0.9	1.5	2.7	2.1	1.4	2.7	2.4	1.6	2.9	2.6	1.8	2.3
Medication: Co-codamol	2.0	2.4	4.1	1.0	1.1	1.8	1.5	1.7	1.8	1.0	0.9	2.0	1.9	1.2	1.8
Ever unenthusiastic/disinterested for a whole week	2.0	2.4	3.3	0.8	1.6	1.7	1.5	0.5	1.7	1.7	1.7	1.8	1.8	1.6	1.6
Body fat percentage	2.0	7.9	12.6	1.4	2.6	2.9	3.5	0.3	2.9	2.9	2.8	3.5	3.5	3.1	2.5
Trunk fat mass	1.9	8.2	13.4	1.4	2.5	3.0	3.6	0.3	3.0	3.0	2.8	3.7	3.5	3.1	2.6
Mood swings	1.9	3.5	6.0	0.4	1.6	1.6	2.3	-0.5	1.6	1.7	2.1	2.5	2.4	2.3	2.0
Pack years of smoking	1.9	2.8	6.6	1.3	0.4	2.1	1.7	0.3	2.1	1.0	1.0	2.1	2.1	1.6	2.6
Illnesses of mother	1.8	2.3	3.5	-0.5	-1.7	-1.7	-1.7	-1.1	-1.7	-1.5	-1.7	-1.9	-1.6	-1.6	-1.0
Whole body fat mass	1.8	7.5	12.2	1.2	2.4	2.8	3.4	0.1	2.8	2.8	2.8	3.5	3.4	3.1	2.5
Medication: Atenolol	1.7	2.2	3.4	1.5	1.2	1.7	1.0	0.7	1.7	1.4	1.9	1.6	1.4	1.7	1.5
Noisy workplace	1.7	2.1	4.2	1.5	1.9	1.0	1.8	0.5	1.0	1.3	2.0	1.2	1.3	1.9	1.0
Leg fat percentage (right)	1.7	6.3	9.7	1.1	2.5	2.4	2.8	0.0	2.4	2.5	2.8	3.1	3.1	3.0	2.4
Mean time to correctly identify matches	1.7	3.2	4.9	0.6	2.2	2.0	0.9	0.9	2.0	1.6	1.9	2.1	2.2	2.0	1.9
Handedness (chirality/laterality): Left-handed	1.7	2.1	5.5	1.7	2.0	1.2	0.7	2.3	1.2	1.4	1.6	1.0	1.0	1.3	0.9
Osteoporosis (self-reported)	1.7	2.1	4.3	-1.7	-1.7	-1.0	-1.8	0.1	-1.0	-1.7	-2.1	-1.2	-1.2	-1.9	-0.9
Smoking status: Current	1.7	2.7	3.7	1.9	1.6	1.7	0.7	1.8	1.7	1.6	1.8	1.3	1.4	1.8	1.9
Number of self-reported non-cancer illnesses	1.7	2.9	5.3	0.1	1.5	2.2	1.7	-0.0	2.2	1.3	1.6	2.3	2.2	1.7	1.9
Medication: Bendroflumethiazide	1.7	2.5	3.5	1.5	1.9	1.7	1.4	1.3	1.7	1.2	1.8	1.6	1.5	1.7	1.5
Leg fat mass (left)	1.7	6.8	10.6	1.2	2.4	2.6	3.2	0.1	2.6	2.6	2.8	3.3	3.2	3.0	2.4
Type 2 Diabetes (T2D) (2018)	1.6	3.1	8.3	-2.4	-2.9	-1.1	0.1	-2.1	-1.1	-1.5	-2.5	-0.9	-1.0	-2.1	-1.0
Systolic blood pressure, automated reading	1.6	4.7	7.5	1.1	2.3	2.4	1.8	0.7	2.4	2.1	2.4	2.7	2.6	2.4	2.2
Multivitamins +/- minerals	1.6	2.0	4.6	1.6	2.1	1.1	1.9	0.9	1.1	0.8	1.7	1.2	1.2	1.5	1.1
Pain all over the body in last month	1.6	1.8	3.2	0.5	1.7	1.3	0.9	1.8	1.3	1.6	1.5	1.4	1.4	1.2	0.6
Medication: Allopurinol	1.6	2.1	5.3	0.7	0.4	1.6	2.3	-0.5	1.6	0.6	1.0	1.6	1.6	1.4	2.3
Leg fat mass (right)	1.6	6.1	9.9	1.0	2.3	2.5	2.9	-0.0	2.5	2.5	2.6	3.1	3.1	2.9	2.3
Diabetes diagnosed by doctor	1.6	2.6	6.0	-2.2	-2.5	-1.0	0.7	-1.9	-1.0	-1.7	-2.3	-0.5	-0.8	-1.9	-1.2
Mineral and other dietary supplements	1.6	2.1	4.0	-1.8	-1.6	-1.2	-0.6	-0.7	-1.2	-1.5	-2.0	-1.3	-1.4	-2.0	-1.6
Blood Red Count	1.5	14.2	18.0	3.6	3.5	3.9	3.3	2.8	3.9	3.5	3.9	4.2	4.2	4.1	3.9
Current tobacco smoking	1.5	2.5	3.1	1.6	1.6	1.7	0.6	1.7	1.7	1.5	1.8	1.3	1.5	1.8	1.8
Arm fat percentage (right)	1.5	5.8	9.9	0.8	2.4	2.4	2.9	-0.2	2.4	2.7	2.5	3.1	3.0	2.8	1.9
High blood pressure (siblings)	1.5	2.1	3.8	-0.2	1.6	1.6	1.6	0.5	1.6	1.3	1.4	1.9	1.9	1.5	1.2
Medication: Blood pressure	1.5	2.8	4.2	0.7	1.5	2.0	1.5	1.1	2.0	1.7	1.5	2.1	2.0	1.6	1.8
Supplements: Fish oil (including cod liver oil)	1.5	2.0	3.9	1.6	1.5	1.2	0.7	0.8	1.2	1.2	1.8	1.4	1.4	2.0	1.7
Alcohol drinker status: Previous	1.5	1.7	2.8	1.1	1.6	1.2	0.9	0.5	1.2	1.4	1.7	1.4	1.4	1.6	1.0
HDL Cholesterol	1.4	2.4	5.5	1.4	1.7	1.6	0.3	2.4	1.6	1.3	1.7	1.3	1.4	1.6	1.6
Lung FEV1/FVC ratio	1.4	7.2	12.4	2.3	2.6	2.7	2.3	2.3	2.7	3.5	2.9	2.5	2.7	2.9	2.5
Waist circumference	1.4	5.1	8.1	1.0	2.3	2.3	2.5	0.7	2.3	2.3	2.4	2.9	2.8	2.6	2.0
Illnesses of siblings	1.4	2.0	3.3	-0.2	-1.5	-1.5	-0.9	-1.2	-1.5	-0.9	-1.5	-1.8	-1.8	-1.6	-1.6
Pulse rate, automated reading	1.4	4.4	8.2	1.3	0.7	2.5	2.9	0.6	2.5	1.8	1.4	2.5	2.5	1.8	2.9
Arm fat percentage (left)	1.4	5.7	9.2	1.0	2.4	2.3	2.7	-0.0	2.3	2.7	2.6	3.0	2.9	2.8	1.9
Mean Putamen Volume	1.3	1.5	3.8	-1.5	-0.9	-1.0	0.4	-1.9	-1.0	-0.9	-1.5	-0.6	-0.8	-1.5	-1.6
Primary Biliary Cirrhosis	1.3	1.9	3.5	-0.4	-1.0	-1.6	-1.6	0.2	-1.6	-1.2	-1.2	-1.9	-1.8	-1.5	-1.4
Systolic Blood Pressure	1.3	6.6	11.8	1.1	1.9	3.2	2.5	0.8	3.2	2.4	2.3	3.4	3.2	2.5	2.8
Alcohol usually taken with meals	1.3	2.1	4.0	-2.0	-1.5	-1.6	-1.3	-1.6	-1.6	-0.9	-1.4	-1.4	-1.4	-1.3	-1.3
Arm fat mass (right)	1.3	5.4	9.5	0.6	2.2	2.3	3.0	-0.1	2.3	2.5	2.3	3.1	3.0	2.6	1.9
Blood clot in the leg (DVT)	1.3	1.7	8.1	-0.3	1.2	0.8	2.9	-0.6	0.8	1.4	1.1	1.2	1.3	1.4	0.6
Birth weight	1.3	2.7	4.5	1.1	1.1	1.8	0.7	1.2	1.8	2.1	1.7	1.9	2.0	2.0	1.8
Shortness of breath walking on level ground	1.3	1.5	3.3	-1.7	-0.4	-1.5	-0.7	-1.8	-1.5	-1.2	-0.7	-1.1	-1.1	-0.9	-1.5
Comparative height size at age 10	1.3	6.9	10.0	2.0	1.7	3.2	2.2	2.1	3.2	2.6	2.2	3.0	3.0	2.6	3.1
Age at last live birth	1.3	1.9	3.3	-0.4	-1.1	-1.8	-1.0	-0.3	-1.8	-1.8	-1.3	-1.6	-1.7	-1.4	-1.6
Deep venous thrombosis (DVT) (self-reported)	1.3	1.6	8.0	-0.4	1.2	0.8	2.8	-0.7	0.8	1.3	1.1	1.3	1.3	1.4	0.6
Schizophrenia vs Biploar Disorder	1.2	1.6	3.8	1.2	1.9	1.1	0.3	1.6	1.1	0.9	1.7	1.0	1.0	1.4	0.9
Major Depression (MDD)	1.2	1.4	2.9	0.1	1.3	1.4	1.3	0.2	1.4	1.2	1.0	1.7	1.5	1.1	0.8
Ever used hormone-replacement therapy (HRT)	1.2	1.5	5.9	0.2	1.4	1.1	2.4	-0.2	1.1	0.8	1.1	1.5	1.3	1.1	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	4.6	1.4	0.5	1.1	1.0	0.6	1.1	1.0	1.2	1.1	1.5	1.5	2.1
Asthma	1.2	2.3	3.6	-1.3	-1.7	-1.2	-1.9	-0.6	-1.2	-1.6	-1.6	-1.5	-1.6	-1.8	-1.6
Lung cancer (father)	1.2	1.4	2.3	0.6	1.2	1.2	0.5	0.0	1.2	1.5	1.5	1.3	1.3	1.5	1.3
Exposure to tobacco smoke at home	1.2	1.3	2.5	1.6	1.2	0.7	1.4	-0.1	0.7	1.2	1.6	1.1	1.0	1.4	0.7
Birth weight of first child	1.2	2.1	5.1	-0.9	0.9	1.5	2.1	-0.4	1.5	1.7	0.8	2.3	1.9	1.1	1.1
Number of full brothers	1.2	1.5	2.0	-1.3	-0.7	-1.3	-1.4	-1.1	-1.3	-1.3	-1.1	-1.2	-1.2	-1.2	-1.4
Arm fat mass (left)	1.2	5.0	8.8	0.6	2.1	2.2	2.7	-0.1	2.2	2.5	2.3	3.0	2.9	2.6	1.8
Medication: Lisinopril	1.2	1.6	4.2	-0.4	0.2	1.5	1.1	-0.4	1.5	0.5	0.6	2.0	2.0	1.1	1.7
Alzheimer’s Disease (including proxy)	1.1	1.6	2.4	-0.6	-1.0	-1.2	-1.2	-0.1	-1.2	-1.4	-1.3	-1.5	-1.6	-1.5	-1.5
Heel T-Score	1.1	8.9	18.1	3.9	2.7	2.2	4.3	0.5	2.2	3.2	3.5	2.6	2.8	3.4	2.8
Cardiovascular Disease	1.1	3.7	5.4	1.3	2.3	2.2	1.3	0.9	2.2	2.0	2.2	2.1	2.1	2.1	1.9
Maternal smoking around birth	1.1	1.5	3.6	0.1	1.1	1.3	1.9	-0.3	1.3	1.4	1.3	1.6	1.4	1.3	0.7
Taking other prescription medications	1.1	1.7	4.3	-1.5	-2.1	-0.8	-0.4	-0.8	-0.8	-1.6	-1.9	-0.8	-1.0	-1.7	-1.0
Weight	1.1	5.6	8.9	1.1	2.0	2.5	2.9	0.4	2.5	2.6	2.3	3.0	2.9	2.6	2.3
Father’s age at death	1.1	1.4	2.3	-0.6	-0.6	-1.4	-0.4	-1.1	-1.4	-1.4	-1.2	-1.4	-1.3	-1.3	-1.5
Mouth/teeth dental problems: Dentures	1.1	1.9	3.1	1.8	1.1	1.3	1.0	1.1	1.3	0.9	1.6	1.5	1.5	1.8	1.5
Length of working week for main job	1.1	1.2	7.7	-1.8	-0.5	-0.8	0.5	-2.8	-0.8	-0.7	-0.7	-0.3	-0.3	-0.6	-0.5
Headache pain in last month	1.1	1.8	3.2	-1.3	-1.8	-1.3	-1.0	-1.0	-1.3	-1.3	-1.6	-1.5	-1.4	-1.5	-0.9
Exposure to tobacco smoke outside home	1.1	1.5	2.9	1.1	0.2	1.1	1.5	-0.6	1.1	1.4	1.2	1.2	1.3	1.5	1.7
Wheeze or whistling in the chest in last year	1.1	1.9	4.2	-1.0	-1.1	-1.2	-2.0	0.1	-1.2	-1.1	-1.2	-1.6	-1.7	-1.5	-1.6
Osteoarthritis (self-reported)	1.1	1.5	3.0	0.3	1.1	1.6	0.2	1.7	1.6	1.7	1.0	1.1	1.1	0.8	1.2
Qualifications: CSEs or equivalent	1.0	1.3	3.8	0.9	2.0	0.9	0.7	-0.1	0.9	1.1	1.6	1.1	1.1	1.3	0.8
Past tobacco smoking	1.0	1.9	4.6	-1.9	-1.4	-1.0	-0.5	-2.1	-1.0	-1.0	-1.7	-1.1	-1.1	-1.6	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.2	2.5	0.5	-0.4	1.4	1.6	-0.2	1.4	1.0	0.5	1.5	1.4	0.9	1.2
Friendships satisfaction	1.0	1.3	2.1	-0.9	-0.5	-1.3	-0.6	-0.5	-1.3	-1.4	-1.2	-1.2	-1.2	-1.4	-1.4
Asthma (self-reported)	1.0	2.0	2.9	-1.3	-1.7	-1.1	-1.6	-0.7	-1.1	-1.5	-1.6	-1.3	-1.4	-1.7	-1.5
Alcohol drinker status: Never	1.0	1.2	2.0	-0.8	-1.1	-1.3	-0.8	-0.7	-1.3	-0.9	-1.0	-1.1	-1.2	-1.1	-1.4
Ever smoked	1.0	1.8	5.3	1.9	1.5	1.0	0.5	2.3	1.0	0.9	1.5	0.8	0.9	1.3	1.3
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.4	-0.8	-1.1	-1.6	-0.6	-0.1	-1.6	-0.6	-0.8	-1.4	-1.2	-1.0	-1.2
Alzheimer’s Disease (in father)	0.9	1.0	2.9	-1.0	-1.4	-0.5	0.3	-1.7	-0.5	-0.9	-1.3	-0.8	-0.7	-1.0	-0.4
Lupus	0.9	1.4	2.2	-0.7	-0.8	-1.5	-1.1	-0.5	-1.5	-1.5	-1.0	-1.2	-1.4	-1.1	-1.2
Ever had hysterectomy (womb removed)	0.9	1.0	2.2	-1.4	-0.4	-1.0	-0.3	-1.3	-1.0	-0.6	-0.9	-0.8	-0.9	-0.9	-1.5
Medication for hormone replacement therapy	0.9	1.0	3.9	-1.6	-0.5	-0.9	0.5	-2.0	-0.9	-0.8	-0.7	-0.5	-0.7	-0.7	-1.3
High blood pressure (mother)	0.9	1.3	2.4	-0.6	1.1	1.4	0.9	-0.4	1.4	1.1	1.1	1.6	1.5	1.2	1.0
Hip circumference	0.9	3.7	6.3	0.7	2.1	2.0	2.2	0.3	2.0	2.0	1.9	2.5	2.4	2.1	1.6
Medication: Lansoprazole	0.9	1.0	1.7	-0.3	-1.0	-1.2	-0.6	-0.2	-1.2	-0.9	-1.0	-1.3	-1.3	-1.1	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.9	0.6	0.4	1.5	1.0	0.3	1.5	1.3	1.2	1.3	1.3	1.3	1.7
Chronic bronchitis/emphysema (mother)	0.9	1.0	2.0	0.3	1.2	0.9	0.8	-0.5	0.9	0.6	1.4	1.1	1.2	1.4	1.2
Medication: Seretide 50 evohaler	0.9	1.1	1.6	-1.0	-0.7	-1.0	-0.9	-0.9	-1.0	-1.1	-1.1	-1.0	-1.0	-1.1	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.6	-0.4	0.1	-1.6	-0.6	-1.1	-1.6	-1.1	-0.3	-1.1	-1.2	-0.4	-1.4
Chest pain or discomfort	0.9	1.3	3.5	-0.1	-0.9	-1.2	-0.6	-0.4	-1.2	-1.9	-0.9	-1.5	-1.5	-1.0	-1.0
Fractured/broken bones in last 5 years	0.9	1.1	3.8	1.2	1.0	1.1	0.7	2.0	1.1	1.0	0.7	1.0	0.7	0.7	0.5
Depressed Affect (Nagel 2018)	0.8	1.7	2.9	0.4	1.2	1.4	0.9	0.8	1.4	1.4	1.5	1.7	1.6	1.5	1.5
Number of treatments/medications taken	0.8	1.4	2.8	-0.2	0.6	1.2	1.7	-0.7	1.2	0.7	1.1	1.6	1.6	1.3	1.3
Age when periods started (menarche)	0.8	2.0	3.0	-1.6	-1.5	-1.3	-1.7	-0.6	-1.3	-1.3	-1.6	-1.5	-1.4	-1.5	-1.3
Chronic bronchitis/emphysema (father)	0.8	1.0	2.4	0.9	0.4	0.8	1.6	-0.5	0.8	0.7	1.1	0.8	0.9	1.2	1.4
Body mass index (BMI)	0.8	3.6	5.9	0.7	1.8	1.7	2.4	-0.1	1.7	2.1	2.1	2.4	2.4	2.2	1.6
Financial difficulties in last 2 years	0.8	1.1	3.4	-0.1	0.8	0.7	1.9	-0.8	0.7	1.0	1.0	1.5	1.4	1.2	0.5
Hair/balding pattern: Pattern 3	0.8	1.2	1.6	0.3	1.1	1.1	1.2	-0.0	1.1	1.2	1.3	1.2	1.3	1.3	1.0
Illnesses of siblings: Diabetes	0.8	1.0	3.4	1.6	1.2	0.7	-0.6	1.8	0.7	0.3	1.0	0.6	0.5	0.8	0.8
Medication: Paracetamol	0.8	1.3	2.0	0.8	1.1	1.2	1.1	1.0	1.2	1.4	1.2	1.1	1.1	1.2	1.1
Ulcerative Colitis (UC)	0.7	1.2	3.5	1.9	1.7	1.0	0.8	1.2	1.0	1.1	1.3	0.3	0.3	1.0	0.8
Bipolar Disorder (2011)	0.7	0.7	1.0	0.5	0.6	0.9	1.0	0.3	0.9	0.9	0.7	1.0	0.9	0.8	0.9
Fasting Glucose	0.7	0.8	1.5	1.0	0.4	1.1	0.7	0.5	1.1	1.2	0.7	0.8	0.8	0.8	1.2
Hearing difficulty/problems: Yes	0.7	1.1	1.9	0.2	0.6	1.2	0.5	0.9	1.2	1.1	1.0	1.3	1.4	1.2	1.2
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	1.8	-0.8	-1.3	-0.7	-0.9	0.0	-0.7	-1.0	-1.2	-1.0	-1.0	-1.3	-0.9
Relative age voice broke	0.7	1.1	1.9	-0.7	-0.2	-1.2	-1.4	-0.8	-1.2	-1.0	-0.8	-1.3	-1.2	-1.1	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	5.2	0.8	1.3	0.7	2.3	-1.2	0.7	1.1	1.5	1.1	1.1	1.4	0.8
Mouth/teeth dental problems	0.7	1.1	3.3	-1.8	-0.3	-0.9	-0.4	-1.2	-0.9	-0.7	-1.1	-0.8	-0.9	-1.2	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.0	0.8	0.9	1.1	0.6	1.1	1.1	1.4	1.0	1.1	1.1	1.0	1.4
Alcohol intake frequency.	0.7	1.7	3.3	-1.6	-1.1	-1.3	-1.4	-0.7	-1.3	-1.2	-1.2	-1.1	-1.1	-1.4	-1.8
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	3.0	-0.5	-0.1	-1.0	-1.7	0.6	-1.0	-0.7	-0.6	-1.2	-1.1	-0.9	-1.0
Supplements: Vitamin C	0.7	0.8	3.4	0.1	-0.8	-0.8	-1.9	0.1	-0.8	-1.3	-0.7	-1.0	-0.9	-0.6	-0.1
Average weekly champagne plus white wine intake	0.7	0.9	3.8	0.3	0.3	-0.8	-1.9	1.1	-0.8	-0.9	-0.2	-1.2	-1.2	-0.6	-0.6
Wears glasses or contact lenses	0.7	0.8	1.9	-0.7	0.4	0.4	1.4	-0.9	0.4	0.9	0.9	1.2	1.3	1.1	0.6
Eye problems/disorders: Glaucoma	0.7	0.8	1.7	1.2	1.3	0.9	0.8	1.2	0.9	0.3	0.9	0.6	0.7	0.7	0.8
Commuting to job workplace: Cycle	0.7	0.8	1.1	-1.1	-0.8	-1.0	-0.5	-0.8	-1.0	-0.8	-1.0	-0.8	-1.0	-1.1	-1.1
Reaction Time	0.6	1.1	2.5	0.1	1.6	1.2	-0.3	0.9	1.2	0.8	1.1	1.2	1.2	1.1	1.0
LDL Cholesterol	0.6	1.0	1.9	-1.4	-1.4	-0.6	-1.2	-0.0	-0.6	-1.2	-1.3	-0.7	-0.7	-1.1	-0.8
Relative age of first facial hair	0.6	1.1	2.8	-1.0	-0.8	-1.1	-1.2	-1.7	-1.1	-1.0	-0.8	-1.0	-1.0	-0.9	-1.2
Diabetes (self-reported)	0.6	0.9	2.7	-1.4	-1.7	-0.2	0.8	-1.2	-0.2	-0.6	-1.4	0.2	-0.1	-1.0	-0.4
Medication: Ramipril	0.6	0.7	2.0	0.3	0.8	0.7	0.9	-0.3	0.7	0.3	1.0	1.4	1.3	1.2	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.5	0.3	-0.2	1.0	1.6	-0.7	1.0	0.8	0.3	0.9	0.9	0.5	1.0
Tense / ‘highly strung’	0.6	1.0	1.8	-0.5	0.7	1.2	1.3	-0.4	1.2	0.6	0.8	1.4	1.2	1.0	1.3
Eye problems/disorders: Cataract	0.6	0.7	3.5	0.7	0.2	-0.3	-1.6	1.9	-0.3	-0.1	0.1	-0.9	-0.8	-0.2	-0.1
Blood White Count	0.5	3.5	6.6	0.1	1.5	2.4	1.9	0.8	2.4	1.9	1.4	2.6	2.4	1.7	1.6
Allergy or Eczema	0.5	1.2	2.2	-1.5	-0.8	-1.2	-0.3	-0.7	-1.2	-1.0	-1.1	-1.1	-1.1	-1.2	-1.4
Vitamin and mineral supplements	0.5	0.7	2.0	-1.1	-1.4	-0.6	-0.4	-0.7	-0.6	-0.1	-1.1	-0.6	-0.6	-1.0	-0.8
Stomach or abdominal pain in last month	0.5	0.6	1.4	-0.1	0.4	0.6	1.1	0.2	0.6	0.6	0.6	1.1	1.2	0.9	0.7
Number of live births	0.5	0.7	1.4	0.8	1.0	0.9	0.6	1.2	0.9	1.0	0.7	0.8	0.8	0.6	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	2.6	0.2	1.1	1.2	1.6	-0.3	1.2	1.2	1.1	1.5	1.6	1.4	1.2
Hair/balding pattern: Pattern 4	0.5	1.2	2.1	-0.8	-1.2	-1.2	-0.4	-0.8	-1.2	-0.8	-1.5	-1.2	-1.2	-1.3	-1.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	2.2	1.5	-0.2	0.7	1.3	0.3	0.7	0.1	0.5	0.2	0.4	0.6	1.4
Gout (self-reported)	0.5	0.7	2.1	0.2	-0.0	0.6	1.4	-1.1	0.6	-0.1	0.4	0.9	0.9	0.8	1.4
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.4	-0.4	-0.5	-0.9	-0.8	-0.8	-0.9	-0.9	-0.4	-1.2	-1.1	-0.7	-1.0
Medication: Blood pressure	0.5	0.8	1.9	-0.3	0.3	1.0	1.0	-1.1	1.0	0.5	0.8	1.4	1.1	0.9	0.7
Number of full sisters	0.5	0.6	2.4	0.4	-0.4	0.7	1.5	-0.8	0.7	0.0	0.2	0.9	0.8	0.5	0.9
Ever taken oral contraceptive pill	0.5	0.5	1.6	-0.5	-1.3	-0.4	-0.4	-0.1	-0.4	-0.7	-1.2	-0.6	-0.6	-1.0	-0.5
Commuting to job workplace: Public transport	0.5	0.6	2.5	0.7	1.3	0.5	1.1	1.6	0.5	0.5	0.5	0.2	0.2	0.2	-0.0
Average weekly beer plus cider intake	0.5	0.7	1.6	1.3	1.1	0.5	1.2	-0.2	0.5	0.9	1.0	0.4	0.5	1.0	0.9
Unable to work because of sickness or disability	0.5	0.7	1.7	0.5	1.3	0.9	0.4	0.6	0.9	0.7	0.9	0.8	0.8	0.8	0.7
Cholesterol lowering medication	0.5	0.8	1.7	0.6	-0.4	-1.0	-0.8	0.1	-1.0	-1.2	-0.5	-1.3	-1.2	-0.8	-0.5
Worry (Nagel 2018)	0.4	0.8	1.6	-0.6	0.7	1.1	1.1	-0.2	1.1	0.4	0.7	1.0	1.0	0.8	1.3
Age at First Birth	0.4	0.6	1.3	-0.2	-0.6	-1.1	-0.4	-0.2	-1.1	-0.8	-0.7	-1.0	-0.9	-0.8	-0.8
HbA1C	0.4	0.4	0.9	0.4	-0.5	0.8	0.5	-0.1	0.8	0.9	0.6	0.8	0.7	0.5	0.8
Neuroticism (2016)	0.4	0.6	1.3	-0.8	0.9	0.7	0.5	-1.0	0.7	0.3	0.7	1.1	1.0	0.8	0.6
Ulcerative Colitis	0.4	0.6	2.5	1.3	1.1	0.2	-0.5	1.6	0.2	0.4	0.4	-0.7	-0.6	-0.1	-0.4
Respiratory disease	0.4	0.9	1.7	-0.7	-1.1	-0.7	-0.6	-0.1	-0.7	-1.0	-1.1	-0.9	-1.1	-1.3	-1.2
Average weekly spirits intake	0.4	0.5	1.3	-1.1	-1.1	-0.4	0.8	-0.9	-0.4	-0.7	-1.0	-0.0	-0.0	-0.5	-0.3
Severe depression (siblings)	0.4	0.5	1.2	0.8	0.8	0.5	-0.3	1.1	0.5	0.6	1.0	0.4	0.5	0.9	0.5
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.9	-0.2	-0.4	-0.7	-0.0	-0.2	-0.7	-0.8	-0.8	-0.9	-1.0	-0.9	-0.5
Sitting height	0.4	2.8	5.2	1.8	0.9	2.3	1.1	1.4	2.3	1.5	1.1	1.8	1.7	1.4	2.1
Hearing difficulty/problems with background noise	0.4	0.6	1.3	-0.2	-0.8	-0.5	-1.1	1.0	-0.5	-0.7	-0.8	-0.8	-0.9	-0.9	-0.7
Had menopause	0.4	0.5	1.7	-0.8	0.1	0.2	1.1	-1.3	0.2	0.2	0.4	0.8	0.8	0.6	0.2
Allergy	0.4	0.9	3.6	1.9	0.7	0.6	-0.4	1.2	0.6	0.5	1.1	0.6	0.7	1.1	1.2
Comparative body size at age 10	0.4	1.1	1.8	1.1	0.8	1.0	0.0	1.1	1.0	1.3	1.0	0.8	1.1	1.1	1.4
Number of children fathered	0.4	0.5	1.2	-0.8	-1.1	-0.3	0.7	-1.1	-0.3	-0.5	-1.1	-0.0	-0.1	-0.8	-0.2
Suffer from ‘nerves’	0.4	0.6	1.3	-0.2	0.7	1.1	0.4	0.6	1.1	0.2	0.7	0.9	0.8	0.7	1.1
Had major operations	0.4	0.5	1.7	-0.0	-0.6	-0.6	-1.3	0.7	-0.6	-0.9	-0.6	-0.7	-0.7	-0.7	-0.6
Family relationship satisfaction	0.4	0.5	1.5	-1.1	-1.0	-0.5	0.1	-0.8	-0.5	-1.2	-1.0	-0.3	-0.3	-0.7	-0.1
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.9	-0.2	-0.9	-0.5	-0.7	-0.2	-0.5	-0.5	-0.9	-0.6	-0.7	-0.9	-0.6
Leg fat-free mass (right)	0.4	2.0	3.8	0.6	0.9	1.5	2.0	0.2	1.5	1.6	1.2	1.8	1.8	1.5	1.4
Ever had bowel cancer screening	0.4	0.4	2.1	-1.0	-0.6	-0.6	0.5	-1.4	-0.6	-0.2	-0.5	-0.3	-0.2	-0.3	-0.3
Leg predicted mass (right)	0.4	2.0	3.6	0.7	1.0	1.5	1.9	0.3	1.5	1.6	1.2	1.8	1.8	1.5	1.4
Guilty feelings	0.4	0.6	3.2	1.5	0.4	0.3	-0.6	1.8	0.3	0.6	0.7	-0.1	-0.1	0.3	0.3
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.9	0.2	-0.8	0.6	1.7	-0.2	0.6	0.0	-0.3	0.7	0.7	0.1	0.7
Medication: Atorvastatin	0.4	0.4	1.5	0.0	0.1	0.5	1.1	-0.4	0.5	-0.1	0.3	1.2	1.0	0.7	0.5
Myopia	0.4	0.6	1.5	-1.2	-0.7	-0.7	0.1	-1.1	-0.7	-0.6	-0.8	-0.4	-0.4	-0.6	-0.8
Crohns Disease (2012)	0.3	0.4	1.2	-0.3	0.7	0.7	0.3	0.5	0.7	0.6	0.6	1.1	1.0	0.7	0.3
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.9	-0.3	-0.9	0.0	0.9	-1.4	0.0	-0.1	-0.5	0.4	0.2	-0.1	0.2
Blood Platelet Count	0.3	3.2	7.3	-1.1	-1.9	-1.6	-2.7	0.2	-1.6	-1.9	-2.0	-2.0	-2.0	-2.0	-1.3
Frequency of depressed mood in last 2 weeks	0.3	0.4	2.1	0.8	0.2	0.6	-0.4	1.5	0.6	0.0	0.3	0.2	0.3	0.2	0.9
Diabetes (mother)	0.3	0.4	0.8	0.3	0.5	0.8	0.4	0.9	0.8	0.6	0.6	0.8	0.7	0.5	0.5
Leg fat-free mass (left)	0.3	1.5	2.8	0.2	0.8	1.3	1.6	-0.0	1.3	1.4	1.0	1.7	1.7	1.4	1.2
Average weekly fortified wine intake	0.3	0.4	3.0	-1.7	0.1	0.4	-0.2	0.0	0.4	0.4	-0.6	0.4	0.2	-0.5	-0.5
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.8	0.1	-0.5	-0.6	0.7	-0.1	-0.6	-0.9	-0.8	-0.6	-0.6	-0.6	-0.2
Serious illness, injury or assault to yourself	0.3	0.4	1.0	-0.4	-1.0	-0.3	1.0	-0.9	-0.3	-0.7	-0.6	-0.1	-0.1	-0.3	-0.3
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.2	-1.5	-0.4	-0.6	-0.0	-0.9	-0.6	-0.5	-0.9	-0.6	-0.7	-1.0	-1.1
Medication: Levothyroxine sodium	0.3	0.5	2.9	-0.7	-0.4	0.0	1.2	-1.7	0.0	0.3	0.1	0.7	0.7	0.3	0.1
Leg predicted mass (left)	0.3	1.7	3.1	0.2	0.8	1.3	1.7	-0.0	1.3	1.5	1.1	1.8	1.7	1.4	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	2.8	0.9	0.6	0.3	1.7	-1.3	0.3	0.8	1.1	0.7	0.7	1.0	0.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.5	1.4	-1.2	-0.5	-0.4	0.0	-1.0	-0.4	-0.6	-0.8	-0.5	-0.5	-0.7	-0.7
Neuroticism score	0.3	0.7	1.3	-0.0	1.0	0.8	0.6	0.2	0.8	0.3	1.1	1.0	0.9	1.0	1.1
Time employed in main current job	0.3	0.3	3.0	0.9	0.2	0.1	0.3	1.7	0.1	0.1	-0.0	-0.1	-0.0	-0.1	0.2
Medication: Cholesterol lowering	0.3	0.5	2.9	-1.0	-0.5	-0.0	1.2	-1.7	-0.0	-0.5	-0.4	0.5	0.4	-0.0	-0.0
Pulse wave Arterial Stiffness index	0.3	0.3	0.7	0.5	0.3	0.8	0.5	0.3	0.8	0.2	0.2	0.8	0.7	0.4	0.7
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.5	0.8	-0.1	-0.5	-0.9	1.2	-0.5	-0.0	-0.4	-0.9	-0.7	-0.6	-0.4
Eye problems/disorders: None of the above	0.3	0.4	1.7	-0.5	-0.4	0.5	1.3	-0.9	0.5	0.3	-0.2	0.8	0.7	0.1	0.4
Neck or shoulder pain in last month	0.3	0.4	2.1	0.1	-0.3	-0.7	-1.5	0.4	-0.7	-0.2	-0.1	-0.7	-0.7	-0.3	-0.5
Medication: Omeprazole	0.3	0.3	3.4	0.5	0.2	0.3	0.0	1.8	0.3	0.2	-0.1	0.1	0.2	0.1	0.3
Heart disease (mother)	0.3	0.4	1.0	-0.9	-0.2	-0.6	1.0	-0.1	-0.6	-0.7	-0.7	-0.2	-0.4	-0.7	-0.9
Arm predicted mass (right)	0.3	1.5	2.9	0.8	0.6	1.3	1.7	0.2	1.3	1.1	1.1	1.5	1.6	1.3	1.5
Smoking status: Previous	0.3	0.4	1.4	0.7	0.5	0.4	-0.1	1.2	0.4	0.5	0.9	0.6	0.6	0.8	0.7
Loneliness, isolation	0.3	0.3	0.7	-0.5	-0.4	0.8	0.5	0.0	0.8	0.1	0.2	0.9	0.8	0.4	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.0	0.2	1.0	0.4	0.2	0.8	0.4	0.1	0.5	0.7	0.6	0.5	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.1	0.3	0.1	0.6	0.4	-0.2	0.6	0.4	0.6	0.8	0.9	0.8	1.1
Medication: Aspirin	0.3	0.4	1.7	-0.1	0.2	-0.1	1.3	-0.9	-0.1	-0.2	0.7	0.4	0.4	0.8	0.4
High cholesterol (Self-reported)	0.3	0.6	1.6	-0.0	-0.0	-1.0	-0.0	-1.3	-1.0	-1.1	-0.3	-0.7	-0.8	-0.5	-0.8
Age started oral contraceptive pill	0.3	0.4	2.2	1.1	0.3	0.4	-0.4	1.5	0.4	0.0	0.3	-0.1	0.0	0.2	0.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	3.6	0.3	-0.5	-0.2	-0.2	1.9	-0.2	-0.0	-0.6	-0.4	-0.2	-0.3	0.1
Supplements: Calcium	0.3	0.3	1.3	-1.1	-0.1	-0.1	0.3	-1.1	-0.1	-0.3	-0.5	0.3	0.2	-0.5	-0.3
Neuroticism (Nagel 2018)	0.2	0.6	0.9	-0.2	0.6	0.8	0.5	0.5	0.8	0.7	0.9	1.0	0.9	0.8	0.9
Triglycerides	0.2	0.3	0.7	-0.8	0.1	0.8	0.4	0.1	0.8	0.7	0.0	0.7	0.8	0.2	0.4
BMI	0.2	1.1	2.5	-0.4	1.0	0.7	1.6	-0.7	0.7	1.2	0.9	1.4	1.4	1.1	0.6
Lung FVC	0.2	1.1	2.2	0.3	0.9	0.9	1.5	-0.4	0.9	0.7	1.0	1.4	1.4	1.2	1.0
Neuroticism	0.2	0.4	0.8	-0.0	0.7	0.6	0.0	0.9	0.6	0.4	0.8	0.7	0.6	0.8	0.8
Sensitivity / hurt feelings	0.2	0.3	1.7	0.1	0.6	0.1	-1.3	1.0	0.1	-0.3	0.4	0.1	-0.1	0.0	0.2
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.7	0.8	0.2	0.3	0.3	0.7	0.3	0.1	0.4	0.6	0.5	0.5	0.3
Fed-up feelings	0.2	0.4	1.0	0.1	0.5	0.7	-0.0	0.6	0.7	1.0	0.5	0.6	0.6	0.5	0.6
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	1.0	0.1	0.1	-0.3	-0.9	1.0	-0.3	0.5	0.2	-0.5	-0.4	-0.1	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.2	0.6	-0.0	0.5	0.5	1.1	0.5	0.5	0.4	0.2	0.3	0.4	1.1
Heart attack	0.2	0.3	1.4	0.6	-0.1	0.1	1.2	-0.6	0.1	-0.1	0.2	0.6	0.6	0.6	0.7
Medication: Simvastatin	0.2	0.3	0.9	-0.5	-0.5	-0.5	0.3	-1.0	-0.5	-0.7	-0.5	-0.5	-0.5	-0.6	-0.4
Worrier / anxious feelings	0.2	0.5	0.8	-0.4	0.8	0.8	0.1	0.1	0.8	0.2	0.9	0.8	0.7	0.9	0.9
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.5	-0.2	0.5	0.8	1.2	-0.4	0.8	0.9	0.4	1.0	1.0	0.7	0.7
Pulse rate	0.2	0.4	1.6	-0.5	-0.4	0.5	1.3	-1.0	0.5	-0.0	-0.4	0.6	0.6	-0.2	0.5
Happiness	0.2	0.2	0.6	0.1	-0.1	0.7	0.6	0.5	0.7	0.2	0.1	0.5	0.6	0.2	0.7
Depression (self-reported)	0.2	0.2	0.6	0.1	0.4	0.6	-0.6	0.7	0.6	0.3	0.5	0.3	0.2	0.3	0.1
Standing height	0.2	1.9	3.5	0.8	0.5	1.9	1.5	1.1	1.9	1.4	0.7	1.7	1.6	1.0	1.6
Breastfed as a baby	0.2	0.3	1.2	-0.2	-0.3	-0.3	-1.1	-0.7	-0.3	-0.5	-0.4	-0.7	-0.6	-0.5	-0.2
Pulse wave reflection index	0.2	0.2	0.5	-0.3	-0.7	-0.4	-0.7	-0.4	-0.4	-0.4	-0.4	-0.4	-0.4	-0.3	-0.2
Ever highly irritable/argumentative for 2 days	0.2	0.2	1.4	-1.2	-0.4	-0.1	0.3	-0.9	-0.1	-0.3	-0.3	0.0	-0.0	-0.3	-0.3
Loud music exposure frequency	0.2	0.2	0.4	-0.4	-0.2	-0.4	0.3	-0.4	-0.4	-0.7	-0.2	-0.3	-0.5	-0.3	-0.5
Medication: Paracetamol	0.2	0.3	1.5	0.0	0.3	0.5	-0.4	1.2	0.5	0.8	0.3	0.2	0.1	0.1	-0.0
Glaucoma (self-reported)	0.2	0.2	0.9	0.9	0.3	-0.0	-0.6	0.8	-0.0	-0.4	0.0	-0.6	-0.5	-0.2	0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	3.2	-0.7	-0.6	-0.5	0.1	-1.8	-0.5	0.0	-0.3	-0.0	0.0	-0.1	-0.3
Medication: Amlodipine	0.2	0.3	0.7	-0.1	0.3	0.8	0.2	-0.4	0.8	0.1	0.4	0.8	0.6	0.5	0.8
Arm fat-free mass (right)	0.2	1.0	2.2	0.4	0.4	1.0	1.5	-0.0	1.0	0.9	0.8	1.3	1.4	1.1	1.2
Health satisfaction	0.2	0.2	0.4	0.5	-0.3	-0.6	0.2	-0.4	-0.6	-0.5	-0.5	-0.4	-0.6	-0.6	-0.5
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.9	0.3	-0.1	-0.2	-0.7	0.9	-0.2	-0.5	-0.3	-0.4	-0.5	-0.5	-0.6
Emphysema/chronic bronchitis	0.2	0.2	0.9	-0.9	0.2	-0.4	-0.0	-0.4	-0.4	0.0	-0.3	-0.4	-0.5	-0.4	-0.9
Medication: Ibuprofen	0.2	0.3	0.6	0.1	0.7	0.2	-0.0	-0.2	0.2	0.6	0.7	0.5	0.6	0.7	0.6
Medication: Aspirin	0.2	0.3	1.4	-0.4	-0.3	-0.4	1.2	-1.0	-0.4	-0.5	0.2	0.1	0.0	0.4	0.2
Knee pain experienced in last month	0.2	0.3	0.7	-0.2	-0.5	-0.5	-0.4	0.3	-0.5	-0.8	-0.5	-0.5	-0.6	-0.5	-0.6
Long-standing illness, disability or infirmity	0.2	0.4	0.9	-0.3	-0.0	0.9	0.9	0.3	0.9	0.1	-0.1	1.0	0.7	0.1	0.5
Commuting to job workplace: Walk	0.2	0.2	0.7	0.7	0.3	-0.5	-0.6	0.8	-0.5	-0.1	0.3	-0.4	-0.3	0.3	-0.2
Medication: Gliclazide	0.2	0.2	0.6	0.4	-0.8	-0.5	0.4	-0.7	-0.5	-0.3	-0.4	-0.3	-0.5	-0.3	-0.5
Illnesses of father: None of the above (group 1)	0.2	0.3	1.0	-0.6	1.0	0.4	-0.2	0.1	0.4	0.3	0.6	0.7	0.7	0.7	0.3
Hearing aid user	0.2	0.2	1.1	-0.5	-0.4	-0.4	-1.1	0.3	-0.4	-0.3	-0.4	-0.3	-0.4	-0.3	-0.3
Mother’s age at death	0.2	0.3	0.9	-0.3	-0.0	-0.3	-0.9	0.9	-0.3	0.2	-0.2	-0.5	-0.5	-0.5	-0.8
Illnesses of father: High blood pressure	0.2	0.2	1.0	0.1	-0.5	-0.1	-1.0	0.5	-0.1	-0.2	-0.4	-0.6	-0.5	-0.5	-0.4
Basal metabolic rate	0.2	1.4	2.5	0.3	0.6	1.2	1.6	0.0	1.2	1.2	0.9	1.6	1.6	1.2	1.2
Arm fat-free mass (left)	0.2	0.9	2.2	-0.1	0.2	0.9	1.5	-0.4	0.9	0.8	0.6	1.3	1.3	0.9	1.0
Number of operations (self-reported)	0.2	0.2	0.5	0.2	-0.5	-0.6	-0.0	0.4	-0.6	-0.7	-0.4	-0.6	-0.5	-0.5	-0.2
Irritability	0.2	0.4	1.2	0.8	0.3	0.4	1.1	0.1	0.4	0.2	0.6	0.7	0.7	0.6	0.8
Risk taking	0.2	0.3	0.6	0.8	0.4	0.3	0.7	0.6	0.3	0.1	0.6	0.3	0.4	0.6	0.5
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.6	0.6	-0.2	0.0	0.8	-0.4	0.0	-0.0	0.2	0.4	0.5	0.6	0.7
Arm predicted mass (left)	0.2	1.0	2.5	0.2	0.5	1.0	1.6	-0.3	1.0	0.9	0.7	1.3	1.4	1.0	1.1
Crohns Disease (2017)	0.1	0.2	1.0	-1.0	0.1	-0.3	-0.3	-0.1	-0.3	-0.6	-0.1	0.1	0.0	-0.2	-0.8
Irritable Bowel Disease (IBD)	0.1	0.2	0.9	0.6	1.0	0.2	-0.0	0.8	0.2	0.2	0.6	-0.1	-0.1	0.3	-0.1
Breast Cancer	0.1	0.1	0.6	0.5	-0.2	-0.2	0.8	0.2	-0.2	0.3	-0.0	0.2	0.1	0.0	-0.6
Ovarian Cancer	0.1	0.1	0.8	0.5	0.2	-0.3	0.3	-0.3	-0.3	-0.9	0.1	-0.1	-0.2	0.1	-0.3
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	-0.5	-0.2	-0.1	0.5	0.4	-0.1	0.4	-0.4	-0.2	-0.3	-0.3	-0.4
Rheumatoid Arthritis	0.1	0.2	0.9	0.9	0.1	0.1	-0.1	0.7	0.1	0.2	0.2	-0.2	-0.1	0.2	0.4
Blood Eosinophil Count	0.1	1.1	3.8	-0.4	-0.9	-1.1	-1.9	0.6	-1.1	-1.2	-0.7	-1.3	-1.2	-0.8	-0.6
Height	0.1	1.4	2.6	0.6	-0.1	1.6	1.6	1.0	1.6	1.2	0.4	1.5	1.4	0.8	1.1
Hypothyroidism (self reported)	0.1	0.3	3.2	-0.4	-0.6	-0.3	0.1	-1.8	-0.3	0.0	-0.1	0.0	0.2	0.1	0.1
Tanning	0.1	1.1	6.5	2.5	0.5	0.8	0.8	0.7	0.8	0.3	0.9	0.6	0.5	0.9	1.1
Hand grip strength (left)	0.1	0.2	0.8	0.3	-0.5	0.5	0.5	-0.1	0.5	0.3	-0.1	0.4	0.5	0.3	0.9
Supplements: Zinc	0.1	0.1	0.3	0.5	0.1	0.2	-0.1	-0.2	0.2	-0.0	0.1	0.1	0.1	0.2	0.5
Diabetes (father)	0.1	0.1	0.8	0.9	-0.0	-0.1	0.0	0.4	-0.1	0.5	-0.2	-0.3	-0.2	-0.2	-0.1
Hand grip strength (right)	0.1	0.2	0.7	0.3	-0.3	0.5	0.5	0.1	0.5	0.4	0.1	0.2	0.3	0.3	0.8
Nervous feelings	0.1	0.2	0.9	-0.9	0.8	0.2	0.6	-0.1	0.2	0.1	0.1	0.4	0.1	-0.0	-0.2
Hair/balding pattern: Pattern 2	0.1	0.1	0.4	0.6	-0.1	0.2	-0.3	0.2	0.2	0.1	0.0	0.2	0.1	0.2	0.6
Had other major operations	0.1	0.2	0.8	0.6	-0.1	-0.0	-0.5	0.9	-0.0	-0.3	-0.1	-0.4	-0.2	-0.1	0.5
Forced vital capacity (FVC)	0.1	0.3	1.2	-1.1	-0.5	0.1	0.3	-1.0	0.1	-0.3	-0.6	0.3	0.2	-0.3	-0.0
Impedance of arm (right)	0.1	0.4	0.9	0.2	0.6	0.9	0.5	0.2	0.9	0.8	0.3	0.7	0.6	0.5	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.5	0.0	0.1	-0.5	-0.7	-0.5	-0.5	0.0	0.1	-0.4	-0.3	-0.0	-0.2
Impedance of arm (left)	0.1	0.6	1.0	1.0	0.8	1.0	0.2	0.9	1.0	0.9	0.6	0.6	0.5	0.6	0.7
Peak expiratory flow (PEF)	0.1	0.3	0.7	-0.5	-0.2	-0.3	0.6	-0.8	-0.3	-0.2	-0.6	-0.4	-0.4	-0.6	-0.7
Forced vital capacity (FVC), Best measure	0.1	0.4	0.9	-0.2	0.2	0.8	0.5	-0.5	0.8	0.5	0.3	0.9	0.9	0.7	0.9
Pulse wave peak to peak time	0.1	0.1	0.3	-0.3	-0.0	-0.6	-0.4	0.0	-0.6	-0.1	0.0	-0.6	-0.4	-0.2	-0.5
Migraine (self-reported)	0.1	0.2	1.1	-0.2	-0.4	0.2	1.1	-0.7	0.2	0.2	-0.0	0.2	0.3	0.3	0.4
Leg pain on walking	0.1	0.2	0.4	0.2	0.4	0.0	-0.7	0.5	0.0	0.7	0.5	-0.2	-0.2	0.2	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	-0.1	0.3	-0.2	-0.5	0.3	-0.2	0.6	0.4	0.1	0.2	0.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.7	-0.2	-0.7	-0.0	-0.6	0.3	-0.0	-0.5	-0.9	-0.2	-0.3	-0.6	-0.4
Whole body fat-free mass	0.1	0.6	1.4	-0.1	0.2	0.8	1.2	-0.1	0.8	0.8	0.4	1.1	1.1	0.8	0.8
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.8	0.6	0.5	-0.1	-0.5	0.9	-0.1	0.2	0.6	-0.2	-0.0	0.4	0.1
Breast cancer (self-reported)	0.1	0.2	0.9	1.0	-0.5	-0.0	0.2	-0.2	-0.0	-0.5	-0.4	-0.3	-0.2	-0.4	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.7	0.2	-0.8	-0.3	-0.7	-0.4	-0.3	-0.6	-0.4	-0.3	-0.2	-0.1	0.3
Whole body water mass	0.1	0.5	1.2	-0.1	0.2	0.7	1.1	-0.1	0.7	0.8	0.4	1.0	1.1	0.7	0.7
Miserableness	0.1	0.1	0.5	0.2	0.7	0.3	-0.1	0.5	0.3	0.4	0.6	0.3	0.2	0.3	0.1
Financial situation satisfaction	0.1	0.1	0.2	0.2	-0.1	-0.3	-0.2	-0.3	-0.3	-0.3	-0.1	-0.3	-0.3	-0.2	-0.5
Tinnitus: Yes, now most or all of the time	0.1	0.2	1.1	0.2	0.1	-0.1	-1.0	0.5	-0.1	-0.2	0.4	-0.3	-0.1	0.3	-0.1
Pain experienced in last month	0.1	0.1	0.7	0.3	-0.2	-0.0	0.8	-0.3	-0.0	0.2	-0.3	-0.0	-0.1	-0.3	-0.2
Basal cell carcinoma (self-reported)	0.1	0.1	0.6	0.5	0.8	0.1	0.3	-0.2	0.1	0.3	0.3	-0.2	-0.2	-0.0	-0.1
Heart disease (siblings)	0.1	0.2	0.9	-0.3	-0.2	-0.2	-0.7	1.0	-0.2	-0.4	-0.2	-0.2	-0.2	-0.2	-0.1
Impedance of whole body	0.1	0.5	1.0	0.9	0.5	1.0	0.6	0.5	1.0	0.4	0.4	0.7	0.6	0.5	0.8
Waist Hip Ratio (WHR)	0.0	0.2	0.4	-0.2	-0.1	0.6	0.2	0.5	0.6	0.0	0.2	0.6	0.6	0.3	0.7
Hair Pigment	0.0	0.8	1.8	-1.4	0.5	0.9	1.1	-0.5	0.9	1.1	0.3	1.3	1.1	0.6	0.5
Impedance of leg (right)	0.0	0.1	0.4	-0.3	-0.4	0.1	-0.4	-0.3	0.1	-0.6	-0.5	-0.2	-0.3	-0.4	0.1
Supplements: Glucosamine	0.0	0.0	0.4	0.6	0.0	-0.1	0.1	0.2	-0.1	0.1	0.1	-0.0	0.0	0.2	0.1
Impedance of leg (left)	0.0	0.1	0.2	0.5	0.1	0.4	0.2	0.2	0.4	-0.3	-0.0	0.1	0.1	-0.0	0.4
Trunk fat-free mass	0.0	0.2	0.4	-0.2	-0.1	0.5	0.6	0.1	0.5	0.5	0.1	0.6	0.6	0.4	0.5
Alcohol intake versus 10 years previously	0.0	0.1	0.3	0.1	-0.0	0.0	0.5	-0.5	0.0	0.3	0.1	-0.1	-0.0	-0.1	0.2
Trunk predicted mass	0.0	0.2	0.4	-0.2	-0.2	0.5	0.7	-0.0	0.5	0.4	0.1	0.6	0.6	0.4	0.5
Medication for pain relief, constipation, heartburn	0.0	0.1	0.3	0.3	0.6	0.5	0.1	0.3	0.5	0.1	0.1	0.2	0.1	-0.1	-0.0
Medication for cholesterol	0.0	0.0	0.2	0.1	-0.4	0.0	-0.3	0.3	0.0	-0.0	-0.3	0.0	0.1	-0.0	0.3

Hub : Genes

ALMS1

Models

Trait associations