TWAS hub - ALMS1P

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1710	0.0340	0.0e+00	0.216	0.222	0.229	0.227	0.229	8.8e-26	1.5e-26	1.6e-27	3.4e-27	1.9e-27
2	ROSMAP	Brain Pre-frontal Cortex	0.1338	0.0405	1.3e-12	0.117	0.116	0.116	0.117	0.119	8.3e-15	1.2e-14	1.1e-14	7.3e-15	4.9e-15
3	TCGA	Bladder Urothelial Carcinoma	0.1390	0.0750	4.7e-07	0.085	0.073	0.066	NA	0.084	1.1e-07	9.0e-07	3.1e-06	NA	1.4e-07
4	TCGA	Breast Invasive Carcinoma	0.0849	0.0366	1.9e-09	0.038	0.049	0.045	NA	0.053	2.2e-08	2.7e-10	1.4e-09	NA	4.4e-11
5	TCGA	Cervical Squamous Cell Carcinoma	0.1630	0.0740	1.5e-05	0.097	0.099	0.106	NA	0.105	1.7e-05	1.3e-05	6.7e-06	NA	7.4e-06
6	TCGA	Colon Adenocarcinoma	0.0830	0.0440	2.4e-05	0.040	0.053	0.040	NA	0.041	2.4e-03	5.3e-04	2.4e-03	NA	2.1e-03
7	TCGA	Esophageal Carcinoma	0.2320	0.1060	2.1e-03	0.092	0.119	0.110	NA	0.100	7.6e-04	1.3e-04	2.3e-04	NA	4.4e-04
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.0507	0.0369	3.4e-03	0.029	0.016	0.023	NA	0.029	2.7e-04	5.4e-03	1.2e-03	NA	2.7e-04
9	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1200	0.0690	2.1e-04	0.039	0.058	0.059	NA	0.044	2.7e-03	2.9e-04	2.6e-04	NA	1.6e-03
10	TCGA	Brain Lower Grade Glioma	0.1779	0.0722	5.6e-11	0.089	0.065	0.065	NA	0.076	2.8e-10	6.3e-08	6.4e-08	NA	5.6e-09
11	TCGA	Lung Adenocarcinoma	0.0899	0.0379	1.5e-07	0.069	0.061	0.063	NA	0.064	1.7e-08	1.2e-07	6.9e-08	NA	6.2e-08
12	TCGA	Lung Squamous Cell Carcinoma	0.1439	0.0537	6.3e-12	0.123	0.117	0.123	NA	0.127	7.4e-14	3.3e-13	7.2e-14	NA	2.9e-14
13	TCGA	Ovarian Serous Cystadenocarcinoma	0.0890	0.0470	1.1e-04	0.071	0.063	0.059	NA	0.066	1.5e-05	4.7e-05	8.2e-05	NA	2.9e-05
14	TCGA	Pheochromocytoma and Paraganglioma	0.2050	0.0850	3.0e-05	0.108	0.128	0.116	NA	0.117	4.5e-05	9.1e-06	2.4e-05	NA	2.2e-05
15	TCGA	Prostate Adenocarcinoma	0.1967	0.0654	1.8e-14	0.174	0.154	0.167	NA	0.166	6.7e-18	7.9e-16	3.7e-17	NA	4.5e-17
16	TCGA	Soft Tissue Sarcoma	0.1960	0.0720	7.5e-08	0.114	0.131	0.132	NA	0.140	2.7e-07	3.5e-08	3.0e-08	NA	1.2e-08
17	TCGA	Stomach Adenocarcinoma	0.1950	0.0880	2.2e-07	0.044	0.096	0.094	NA	0.074	3.9e-04	1.9e-07	2.6e-07	NA	4.8e-06
18	TCGA	Testicular Germ Cell Tumors	0.4230	0.1400	3.1e-05	0.136	0.139	0.099	NA	0.123	1.6e-05	1.3e-05	2.3e-04	NA	4.3e-05
19	TCGA	Thyroid Carcinoma	0.2880	0.0750	0.0e+00	0.201	0.231	0.241	NA	0.240	2.9e-19	2.9e-22	2.9e-23	NA	3.5e-23
20	TCGA	Uterine Corpus Endometrial Carcinoma	0.3060	0.1170	6.6e-04	0.185	0.131	0.181	NA	0.171	7.3e-06	1.7e-04	9.5e-06	NA	1.7e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
Verbal and Numeric Reasoning (VNR)	10.3	24.6	30.4	-5.3	-4.9	-5.0	-4.4	-5.5	-4.8	-4.9	-4.6	-5.4	-4.9	-5.1	-5.0	-5.0	-5.2	-4.9	-4.9	-5.1	-4.3	-5.1	-4.8
Qualifications: O levels/GCSEs or equivalent	10.1	16.0	18.7	-4.0	-3.9	-4.1	-3.4	-4.2	-4.0	-4.0	-4.1	-3.9	-4.0	-4.1	-4.1	-3.8	-4.2	-4.2	-4.2	-4.3	-3.2	-4.2	-4.0
Qualifications: nursing, teaching	9.2	14.3	17.9	-4.0	-4.1	-4.2	-3.5	-4.2	-4.2	-3.4	-3.1	-3.8	-4.0	-4.0	-4.0	-4.0	-4.2	-3.5	-3.6	-3.7	-2.9	-3.8	-3.1
Fluid intelligence score	8.5	17.7	26.2	-4.5	-4.1	-4.2	-3.9	-5.1	-4.0	-4.0	-3.8	-4.7	-4.0	-4.2	-4.2	-4.2	-4.5	-4.0	-4.1	-4.2	-3.6	-4.3	-4.1
Prospective memory result	8.5	10.5	15.3	3.5	3.6	3.9	2.7	3.2	3.7	2.7	2.1	3.6	3.9	3.7	3.5	3.9	3.4	2.5	3.0	2.9	2.7	3.1	2.1
Intelligence (Savage-Jansen 2018)	8.2	25.2	33.8	-5.4	-5.0	-5.6	-4.0	-5.7	-5.6	-4.3	-4.6	-5.8	-5.2	-5.3	-5.2	-5.1	-5.2	-4.8	-5.0	-5.0	-3.4	-5.0	-4.5
Schizophrenia (2014)	8.0	17.6	26.3	4.6	4.9	4.6	4.5	4.2	4.0	3.9	2.5	3.7	4.7	5.1	5.1	4.8	4.7	3.2	3.5	3.6	4.3	4.0	2.7
Qualifications: A levels/AS levels or equivalent	7.8	17.3	24.3	-4.3	-4.4	-4.6	-3.0	-4.3	-4.9	-3.6	-4.1	-4.4	-4.5	-4.2	-4.1	-4.3	-4.3	-4.2	-4.4	-4.2	-2.8	-4.2	-3.8
Bipolar Disorder or Schizophrenia	7.5	18.4	26.0	4.9	5.1	4.6	4.5	4.1	4.0	4.1	2.6	4.0	4.8	5.0	5.0	4.8	4.7	3.2	3.6	3.9	4.6	4.1	2.8
Medication: Metformin	7.1	10.1	13.9	-3.3	-2.9	-2.6	-3.4	-3.7	-2.3	-3.4	-3.2	-3.1	-2.6	-3.0	-3.1	-2.9	-3.3	-3.4	-3.2	-3.5	-3.0	-3.4	-3.6
Diabetes diagnosed by doctor	6.8	11.2	17.9	-3.2	-2.6	-2.2	-3.8	-4.0	-1.9	-4.0	-3.7	-2.7	-2.4	-2.8	-3.1	-2.8	-3.6	-3.9	-3.5	-3.7	-3.7	-3.7	-4.2
Schizophrenia (2018)	6.5	13.4	20.5	4.1	4.5	3.8	4.1	3.6	3.1	3.6	2.2	3.4	3.9	4.3	4.3	4.1	4.1	2.8	3.0	3.2	4.1	3.6	2.5
Qualifications: None of the above	6.5	13.9	17.6	4.1	4.0	3.9	3.3	4.2	3.5	3.5	3.3	3.7	3.8	4.2	4.2	3.8	3.9	3.5	3.6	3.4	3.4	3.8	3.3
Diastolic blood pressure, automated reading	6.5	20.3	29.0	4.7	4.7	5.2	3.3	4.7	5.4	3.8	4.0	5.0	5.0	4.8	4.6	5.0	4.8	4.1	4.6	4.3	3.0	4.5	3.7
Coronary Artery Disease (CAD)	6.4	7.6	10.1	2.8	3.2	3.0	1.7	2.6	3.0	2.7	3.1	2.1	2.9	2.8	2.7	2.7	2.8	3.0	3.1	2.8	2.3	2.8	2.5
Type 2 Diabetes (T2D) (2018)	6.1	11.4	15.9	-3.3	-3.0	-2.5	-3.8	-3.8	-2.4	-3.8	-3.6	-2.6	-2.7	-3.0	-3.1	-3.0	-3.7	-3.8	-3.5	-3.7	-3.5	-3.7	-4.0
Illnesses of father: Heart disease	5.6	7.7	9.5	-3.1	-2.7	-2.9	-2.1	-2.7	-2.7	-2.5	-2.8	-2.8	-3.0	-3.1	-3.0	-2.9	-2.7	-2.9	-3.0	-2.3	-2.5	-2.9	-2.7
Qualifications: College or University degree	5.3	16.6	23.3	-4.4	-4.4	-4.8	-3.0	-4.1	-4.7	-3.4	-3.4	-4.7	-4.7	-4.6	-4.4	-4.6	-4.1	-3.6	-4.1	-3.6	-2.9	-4.0	-3.1
Reason for reducing amount of alcohol drunk: Health precaution	4.9	5.8	7.2	2.4	2.7	2.4	2.1	2.5	2.5	2.3	2.2	2.5	2.6	2.5	2.5	2.5	2.7	2.3	2.4	2.3	1.9	2.5	2.1
Osteoporosis (self-reported)	4.9	6.1	9.2	-2.4	-2.5	-2.3	-2.3	-3.0	-2.3	-2.7	-2.5	-2.1	-2.0	-2.4	-2.4	-2.2	-2.8	-2.6	-2.5	-2.7	-2.1	-2.6	-2.5
Noisy workplace	4.8	6.0	7.3	2.4	2.4	2.3	2.2	2.7	2.3	2.5	2.5	2.3	2.4	2.5	2.5	2.3	2.7	2.6	2.5	2.6	1.9	2.6	2.5
Age at first live birth	4.0	7.0	8.9	-2.8	-2.3	-2.9	-1.6	-2.9	-2.9	-2.3	-2.9	-2.9	-2.8	-2.7	-2.6	-2.8	-2.6	-2.8	-3.0	-2.5	-1.9	-2.8	-2.6
Diabetes (self-reported)	3.6	5.6	9.9	-2.2	-1.7	-1.3	-2.9	-2.9	-1.0	-2.9	-2.7	-1.8	-1.6	-2.1	-2.3	-1.9	-2.5	-2.8	-2.5	-2.5	-2.6	-2.7	-3.1
Mineral and other dietary supplements	3.6	4.9	6.6	-2.1	-2.5	-2.4	-2.3	-2.5	-2.4	-1.8	-1.8	-1.6	-2.3	-2.5	-2.5	-2.5	-2.6	-2.1	-2.2	-1.7	-2.0	-2.3	-1.8
Townsend deprivation index at recruitment	3.4	4.7	7.4	2.1	2.3	2.6	2.1	2.3	2.7	1.9	1.7	2.0	2.4	2.2	2.1	2.4	2.6	2.0	2.1	2.1	1.7	2.1	1.7
Bipolar Disorder (2018)	3.3	5.2	7.6	2.6	2.5	2.6	2.1	2.1	2.5	2.1	1.4	2.2	2.8	2.7	2.6	2.6	2.4	1.7	1.9	2.4	2.4	2.1	1.4
Smoking Status	3.3	7.9	10.7	3.1	2.9	2.9	2.8	2.8	2.5	2.7	2.2	3.3	3.0	3.1	3.0	3.1	2.9	2.5	2.7	2.6	2.6	2.9	2.4
Number of incorrect matches in round	3.3	5.4	10.1	2.5	2.9	3.1	1.4	2.2	3.2	1.6	1.8	2.6	2.9	2.8	2.5	2.7	2.4	1.9	2.3	1.5	1.4	2.1	1.4
Back pain experienced in last month	3.3	4.8	6.5	2.5	2.3	2.1	2.0	2.5	1.9	2.2	2.0	2.1	2.1	2.4	2.4	2.2	2.2	2.2	2.2	2.0	2.1	2.3	2.1
Taking other prescription medications	3.1	4.8	6.3	-2.3	-2.0	-1.8	-2.3	-2.4	-1.6	-2.5	-2.4	-1.9	-1.9	-2.0	-2.0	-2.2	-2.4	-2.5	-2.4	-2.2	-2.1	-2.4	-2.5
Worry too long after embarrassment	3.0	5.1	6.5	-2.4	-1.9	-2.3	-1.8	-2.4	-2.1	-2.2	-2.1	-2.0	-2.4	-2.5	-2.6	-2.4	-2.3	-2.1	-2.3	-2.2	-2.3	-2.3	-2.0
Schizophrenia vs Biploar Disorder	2.9	3.8	5.2	1.9	1.8	1.7	1.9	2.0	1.7	2.0	2.2	1.5	1.8	1.9	2.0	1.8	2.1	2.3	2.1	1.9	1.9	2.2	2.3
Prostate Cancer	2.9	4.1	5.9	2.4	2.2	2.1	2.1	2.3	1.8	1.6	1.9	2.0	2.0	2.2	2.1	2.3	1.9	2.1	2.1	1.4	1.6	2.2	1.8
Exposure to tobacco smoke at home	2.9	3.2	4.5	1.7	1.8	1.7	1.5	1.8	2.0	1.9	1.9	1.5	1.8	1.6	1.5	1.8	2.1	2.0	2.0	1.9	1.6	1.9	1.8
Supplements: Fish oil (including cod liver oil)	2.9	3.7	5.4	1.8	2.3	2.3	2.1	2.1	2.3	1.4	1.2	1.3	2.2	2.2	2.2	2.3	2.3	1.5	1.7	1.5	1.8	1.9	1.2
Alzheimer’s Disease (in mother)	2.8	3.3	6.7	-1.6	-1.3	-2.2	-1.1	-2.0	-2.6	-1.3	-1.8	-2.0	-2.0	-1.7	-1.5	-2.0	-1.9	-1.8	-2.0	-2.0	-0.8	-1.8	-1.7
Alcohol drinker status: Previous	2.8	3.2	4.2	1.8	1.7	1.8	1.4	1.7	1.8	1.9	1.8	1.2	1.9	1.8	1.8	1.8	2.0	1.8	1.9	1.8	2.1	1.8	1.7
Mean Putamen Volume	2.7	3.1	7.0	-1.9	-1.8	-1.8	-2.6	-1.8	-1.1	-1.7	-0.9	-1.6	-1.8	-2.0	-2.0	-2.1	-1.9	-1.4	-1.4	-1.4	-2.0	-1.9	-1.3
Handedness (chirality/laterality): Left-handed	2.7	3.3	5.5	1.9	1.9	1.5	1.8	2.0	1.2	2.2	1.7	1.9	1.4	1.5	1.5	1.6	1.8	1.9	1.8	2.3	1.9	1.9	2.0
Angina	2.6	3.4	6.2	1.8	2.3	2.3	1.5	2.0	2.5	1.4	1.0	1.9	2.1	2.1	2.0	2.1	2.2	1.3	1.5	1.9	1.4	1.6	0.9
Angina (self-reported)	2.6	3.4	5.8	1.8	2.2	2.3	1.5	2.0	2.4	1.5	1.1	1.9	2.1	2.0	1.9	2.0	2.2	1.4	1.5	2.0	1.4	1.6	1.1
Depression (Nagel 2018)	2.3	3.5	5.1	2.1	2.1	2.1	1.7	1.4	1.4	2.0	1.5	2.3	2.1	2.2	2.2	2.2	1.7	1.7	1.8	1.5	1.5	2.0	1.5
Medication: Atenolol	2.2	2.8	3.7	1.7	1.9	1.5	1.4	1.9	1.6	1.7	1.5	1.5	1.5	1.6	1.6	1.6	1.9	1.6	1.6	1.9	1.8	1.7	1.6
Medication: Bendroflumethiazide	2.1	3.2	5.3	1.8	1.9	1.9	1.5	2.0	1.9	1.8	1.4	1.8	1.9	1.9	1.9	1.8	2.0	1.5	1.6	2.3	1.6	1.7	1.5
Ever depressed for a whole week	2.1	2.6	6.1	1.6	1.8	2.2	0.8	1.4	2.5	1.3	1.1	1.7	2.0	1.7	1.6	1.7	1.8	1.2	1.4	2.1	1.3	1.4	0.9
Vascular/heart problems diagnosed by doctor	2.1	5.8	8.6	-2.5	-2.8	-2.7	-1.4	-2.2	-2.9	-2.1	-2.3	-2.4	-2.6	-2.5	-2.4	-2.5	-2.5	-2.3	-2.5	-2.5	-1.9	-2.3	-2.0
LDL Cholesterol	2.0	3.1	4.1	-1.8	-1.6	-1.5	-2.0	-2.0	-1.4	-1.9	-1.6	-1.4	-1.6	-1.8	-1.9	-1.7	-2.0	-1.8	-1.7	-2.0	-1.9	-1.9	-1.8
Heel T-Score	2.0	15.9	21.5	3.8	4.0	4.2	3.7	4.6	4.5	3.6	3.5	4.2	4.1	4.1	4.2	4.2	4.5	3.7	3.9	4.0	2.8	4.1	3.5
Number of children fathered	2.0	2.2	4.4	-1.5	-1.3	-1.1	-2.1	-1.6	-0.7	-1.8	-1.2	-1.2	-1.1	-1.4	-1.6	-1.3	-1.7	-1.5	-1.3	-1.7	-1.7	-1.6	-1.6
Smoking status: Current	2.0	3.1	4.2	1.9	1.4	1.5	1.9	1.6	1.3	2.0	1.6	2.0	1.8	1.7	1.8	1.9	1.8	1.7	1.8	1.9	1.8	1.9	1.8
Alzheimer’s Disease (in father)	1.9	2.1	3.1	-1.5	-1.2	-1.2	-1.4	-1.4	-0.9	-1.8	-1.6	-1.4	-1.4	-1.4	-1.5	-1.4	-1.5	-1.6	-1.6	-1.4	-1.7	-1.6	-1.6
Current tobacco smoking	1.9	3.0	3.8	1.9	1.3	1.5	1.7	1.7	1.4	1.9	1.7	1.9	1.8	1.7	1.7	1.9	1.8	1.8	1.9	1.9	1.7	1.9	1.9
Illnesses of mother	1.9	2.4	4.6	-1.4	-1.7	-1.8	-0.7	-1.4	-2.1	-1.4	-1.9	-1.7	-1.5	-1.2	-1.1	-1.3	-1.6	-1.8	-1.7	-2.0	-0.8	-1.5	-1.6
Ever taken oral contraceptive pill	1.9	2.1	3.1	-1.3	-1.5	-1.4	-1.6	-1.1	-1.6	-1.4	-1.3	-0.5	-1.6	-1.6	-1.7	-1.5	-1.8	-1.4	-1.4	-1.3	-1.6	-1.5	-1.3
HDL Cholesterol	1.8	3.0	3.9	1.9	1.5	1.5	1.7	1.6	1.3	2.0	1.7	1.6	1.7	1.7	1.6	1.7	1.8	1.8	1.8	1.8	1.9	1.9	1.9
Leg fat percentage (left)	1.8	6.3	11.8	2.6	3.2	3.2	1.3	2.2	3.4	2.0	2.3	2.7	2.9	2.5	2.2	2.9	2.6	2.4	2.7	2.3	1.5	2.4	1.8
Lung FEV1/FVC ratio	1.7	8.5	11.2	3.0	2.7	2.9	2.0	3.1	3.1	2.8	3.3	3.2	2.8	2.6	2.5	2.8	3.0	3.3	3.3	3.1	2.2	3.1	3.2
Qualifications: CSEs or equivalent	1.7	2.2	3.0	1.6	1.7	1.3	1.4	1.3	1.2	1.6	1.7	1.4	1.4	1.3	1.2	1.4	1.6	1.7	1.7	1.3	1.4	1.6	1.6
High blood pressure	1.7	4.8	7.0	2.4	2.4	2.5	1.0	2.0	2.6	1.9	2.5	2.5	2.4	2.1	2.0	2.2	2.1	2.3	2.5	2.3	1.3	2.2	2.1
Pain all over the body in last month	1.7	1.8	4.8	1.3	1.2	1.0	0.2	0.8	1.2	1.6	2.2	1.4	1.0	0.7	0.6	0.8	1.1	1.9	1.7	1.9	1.0	1.4	1.9
Average weekly spirits intake	1.6	1.9	3.6	-1.4	-1.3	-0.7	-1.8	-1.3	-0.5	-1.8	-1.5	-1.3	-1.0	-1.0	-1.1	-1.1	-1.4	-1.6	-1.4	-1.6	-1.6	-1.6	-1.9
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.7	5.2	1.7	1.6	1.9	1.4	2.1	2.2	1.9	2.3	1.9	2.0	1.7	1.7	1.9	2.1	2.2	2.2	2.1	1.0	2.0	2.1
Mouth/teeth dental problems: Dentures	1.6	2.7	4.2	1.6	1.8	2.0	1.4	1.6	1.9	1.4	1.0	1.5	1.9	2.0	2.0	1.9	1.9	1.2	1.4	1.6	1.5	1.5	1.0
Lung cancer (father)	1.6	1.8	3.1	1.5	1.8	1.7	1.4	1.2	1.5	1.0	0.9	1.2	1.6	1.6	1.5	1.7	1.4	1.1	1.3	0.9	1.1	1.3	0.8
Birth weight	1.6	3.4	4.7	1.9	1.6	1.9	1.1	1.9	1.8	1.8	2.0	2.2	1.9	1.8	1.6	1.9	1.7	2.0	2.1	1.9	1.5	1.9	1.9
Exposure to tobacco smoke outside home	1.6	2.2	4.4	1.4	1.6	2.1	1.5	1.7	2.0	0.8	0.8	1.4	1.8	1.8	1.7	1.8	1.7	1.0	1.2	1.0	0.8	1.4	0.7
Mood swings	1.6	2.9	5.8	1.6	2.3	2.4	0.7	1.4	2.2	1.2	1.4	2.2	2.2	2.0	1.7	2.1	1.6	1.5	1.8	1.1	0.5	1.6	0.9
Multivitamins +/- minerals	1.5	1.9	4.6	1.5	2.1	1.7	1.4	1.0	1.8	1.0	1.0	1.3	1.6	1.5	1.4	1.5	1.5	1.2	1.3	1.3	0.7	1.3	1.0
Hypertension (Self-reported)	1.5	4.3	6.7	2.2	2.2	2.4	0.6	1.8	2.6	1.8	2.5	2.4	2.2	2.0	1.8	2.0	1.9	2.2	2.4	2.1	1.1	2.0	2.0
Other serious medical condition/disability diagnosed by doctor	1.4	1.9	3.5	-1.4	-1.5	-1.6	-1.4	-1.6	-1.5	-1.0	-1.0	-1.3	-1.6	-1.8	-1.9	-1.6	-1.5	-1.1	-1.2	-0.9	-0.8	-1.4	-0.9
Asthma	1.4	2.7	4.8	-1.4	-1.7	-2.1	-1.3	-1.5	-2.2	-1.4	-1.2	-1.4	-2.0	-1.9	-1.8	-1.9	-1.9	-1.4	-1.5	-1.6	-1.1	-1.6	-1.0
Blood clot in the leg (DVT)	1.4	1.8	4.6	1.1	1.0	1.6	0.4	1.4	2.1	0.9	1.8	1.1	1.4	1.1	1.0	1.2	1.3	1.6	1.6	1.5	0.2	1.3	1.4
Family relationship satisfaction	1.4	1.7	4.0	-1.2	-0.8	-0.6	-1.1	-1.5	-0.8	-1.6	-1.8	-1.0	-0.7	-0.6	-0.7	-0.8	-1.4	-1.7	-1.5	-1.6	-1.6	-1.4	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	3.0	-1.3	-1.7	-1.6	-0.3	-1.0	-1.7	-1.2	-1.2	-1.5	-1.4	-1.1	-0.9	-1.4	-1.2	-1.2	-1.3	-1.4	-1.0	-1.1	-0.9
Asthma (self-reported)	1.4	2.8	4.0	-1.5	-1.7	-2.0	-1.5	-1.4	-2.0	-1.6	-1.3	-1.4	-2.0	-1.9	-1.9	-1.9	-1.9	-1.5	-1.6	-1.8	-1.3	-1.6	-1.2
Alzheimer’s Disease (including proxy)	1.3	1.8	3.5	-1.2	-1.0	-1.7	-0.7	-1.6	-1.9	-0.9	-1.5	-1.6	-1.5	-1.4	-1.3	-1.4	-1.4	-1.4	-1.5	-1.3	-0.6	-1.4	-1.3
Blood Red Count	1.3	12.5	19.2	3.7	3.8	3.9	2.1	3.4	4.2	3.1	3.4	4.4	4.1	3.5	3.4	3.8	3.5	3.3	3.7	3.7	2.4	3.5	3.1
Average weekly fortified wine intake	1.3	1.6	4.9	-1.1	-1.1	-1.0	-2.2	-1.5	-0.9	-1.4	-0.2	-0.5	-1.2	-1.3	-1.5	-1.5	-1.7	-0.7	-0.8	-1.2	-1.7	-1.2	-0.7
Chronic bronchitis/emphysema (mother)	1.3	1.5	2.4	1.3	1.6	1.5	1.2	0.7	1.2	1.1	0.9	0.8	1.5	1.6	1.5	1.4	1.2	1.1	1.1	0.7	1.1	1.2	0.7
Overall health rating	1.3	2.8	5.5	1.9	2.2	2.1	0.7	1.3	2.3	1.5	1.3	2.2	1.9	1.6	1.3	1.8	1.7	1.4	1.6	1.9	1.1	1.4	1.0
Average weekly red wine intake	1.3	1.9	4.0	-1.6	-1.9	-1.9	-0.3	-0.7	-1.9	-1.1	-0.9	-2.0	-1.9	-1.5	-1.3	-1.7	-1.1	-0.9	-1.3	-1.4	-0.7	-1.1	-0.5
Wears glasses or contact lenses	1.3	1.5	3.7	0.9	1.0	1.6	0.1	1.2	1.9	0.6	1.6	1.2	1.4	1.3	1.2	1.2	1.1	1.4	1.5	0.9	-0.2	1.2	1.1
Systolic blood pressure, automated reading	1.2	3.6	7.7	2.0	2.0	2.4	0.8	2.0	2.8	1.2	1.7	2.2	2.3	1.9	1.7	2.3	1.9	1.7	2.1	1.7	0.9	1.8	1.3
Severe depression (siblings)	1.2	1.4	1.9	1.2	1.2	0.9	1.4	1.3	0.8	1.4	1.2	1.2	0.9	1.1	1.1	1.1	1.3	1.3	1.2	0.9	1.1	1.3	1.3
Past tobacco smoking	1.2	2.3	3.8	-1.8	-1.9	-1.6	-1.9	-1.5	-1.2	-1.3	-0.8	-1.7	-1.6	-1.8	-1.8	-1.8	-1.6	-1.2	-1.3	-1.0	-1.4	-1.5	-1.0
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	2.9	1.3	1.5	1.6	0.5	0.9	1.7	1.0	1.2	1.0	1.4	1.2	1.1	1.2	1.3	1.2	1.3	1.3	1.2	1.1	1.0
Headache pain in last month	1.2	2.1	2.9	-1.4	-1.6	-1.3	-0.7	-1.6	-1.5	-1.5	-1.7	-1.5	-1.4	-1.2	-1.2	-1.3	-1.5	-1.6	-1.6	-1.7	-1.3	-1.4	-1.5
Leg fat percentage (right)	1.2	4.4	9.1	2.1	2.7	2.8	0.9	1.9	3.0	1.5	2.0	2.3	2.5	2.1	1.8	2.5	2.1	1.9	2.3	1.7	0.9	1.9	1.4
Friendships satisfaction	1.2	1.5	2.5	-1.1	-0.7	-1.2	-0.8	-1.6	-1.5	-1.0	-1.4	-1.1	-1.2	-1.1	-1.1	-1.3	-1.4	-1.4	-1.5	-1.2	-0.9	-1.3	-1.4
Trunk fat percentage	1.1	4.3	10.3	2.1	2.7	2.9	0.4	1.7	3.2	1.4	2.0	2.5	2.5	2.1	1.8	2.4	2.0	1.8	2.2	1.8	0.7	1.8	1.2
Chronic bronchitis/emphysema (father)	1.1	1.3	2.4	1.1	1.1	1.5	1.3	1.1	1.4	0.6	0.5	1.4	1.4	1.4	1.4	1.6	1.2	0.8	1.0	0.8	0.4	1.1	0.6
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.6	3.4	1.3	1.2	1.6	1.3	1.8	1.8	1.6	1.9	1.5	1.6	1.4	1.5	1.5	1.9	1.8	1.8	1.8	1.0	1.7	1.7
Body fat percentage	1.1	4.4	10.0	2.1	2.7	2.9	0.5	1.8	3.2	1.5	2.0	2.5	2.5	2.1	1.8	2.4	2.0	1.9	2.3	1.8	0.8	1.8	1.3
Number of full brothers	1.1	1.3	2.6	-1.0	-1.1	-1.2	-0.8	-1.6	-1.6	-0.8	-0.9	-1.4	-1.2	-1.1	-1.2	-1.2	-1.4	-0.9	-1.1	-1.3	-0.7	-1.1	-0.9
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	4.2	1.0	0.8	1.5	0.2	1.2	2.0	0.8	1.7	1.0	1.3	1.0	0.9	1.1	1.2	1.4	1.5	1.3	0.1	1.1	1.2
Leg fat mass (left)	1.1	4.5	9.2	2.1	2.8	2.9	0.8	1.8	3.0	1.6	2.0	2.5	2.5	2.2	1.8	2.5	2.1	1.9	2.3	1.7	1.0	1.9	1.3
Type 2 Diabetes (T2D) (2012)	1.0	1.2	3.3	-0.8	-0.4	-0.4	-1.0	-1.2	-0.5	-1.2	-1.7	-0.7	-0.6	-0.6	-0.7	-0.7	-1.0	-1.6	-1.4	-1.4	-0.9	-1.3	-1.8
Trunk fat mass	1.0	4.1	9.8	2.0	2.7	2.9	0.3	1.6	3.1	1.3	2.0	2.6	2.5	2.0	1.7	2.3	1.9	1.8	2.2	1.7	0.6	1.8	1.2
Mouth/teeth dental problems	1.0	1.5	3.1	-1.3	-1.2	-1.3	-1.3	-1.6	-1.1	-1.1	-0.7	-1.0	-1.3	-1.7	-1.8	-1.3	-1.4	-0.9	-1.0	-1.0	-1.4	-1.2	-0.8
Whole body fat mass	1.0	4.3	9.7	2.1	2.7	2.9	0.5	1.7	3.1	1.4	2.0	2.5	2.5	2.1	1.8	2.4	1.9	1.9	2.3	1.6	0.7	1.8	1.2
Leg fat mass (right)	1.0	3.8	8.0	2.0	2.6	2.7	0.6	1.7	2.8	1.4	1.9	2.3	2.4	2.0	1.7	2.3	1.9	1.8	2.2	1.4	0.8	1.8	1.2
Arm fat percentage (left)	1.0	4.0	7.6	2.0	2.5	2.6	0.6	1.7	2.8	1.5	2.2	2.2	2.3	2.0	1.8	2.2	1.9	2.1	2.4	1.6	0.8	1.9	1.5
Pain type(s) experienced in last month: Hip pain	1.0	1.3	3.5	-0.8	-0.5	-0.2	-1.4	-1.2	-0.0	-1.5	-1.6	-0.5	-0.5	-0.6	-0.9	-0.7	-1.1	-1.5	-1.3	-1.4	-1.3	-1.3	-1.9
Medication: Paracetamol	1.0	1.5	2.6	1.3	0.9	1.1	0.8	1.0	1.1	1.4	1.5	1.5	1.2	1.0	0.9	1.2	1.1	1.4	1.4	1.6	0.9	1.3	1.5
Ever smoked	1.0	1.8	3.0	1.6	1.4	1.2	1.7	1.6	0.9	1.3	0.7	1.4	1.2	1.5	1.6	1.5	1.5	1.0	1.1	1.2	1.6	1.3	1.0
Average weekly beer plus cider intake	1.0	1.4	2.7	1.2	1.1	1.2	1.6	1.3	1.1	1.1	0.8	1.4	1.2	1.1	1.0	1.5	1.3	1.0	1.1	1.2	0.8	1.2	1.0
Cardiovascular Disease	0.9	2.8	3.7	1.8	1.9	1.8	1.0	1.5	1.8	1.8	1.7	1.7	1.8	1.7	1.7	1.6	1.7	1.6	1.7	1.9	1.5	1.6	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	2.2	1.2	1.2	1.3	1.1	0.8	0.9	1.0	0.4	1.4	1.5	1.4	1.4	1.5	1.0	0.7	0.9	0.8	1.1	1.0	0.5
Age when periods started (menarche)	0.9	2.3	3.6	-1.5	-1.9	-1.9	-1.2	-1.5	-1.9	-1.1	-1.2	-1.7	-1.7	-1.7	-1.7	-1.6	-1.6	-1.3	-1.4	-1.2	-0.7	-1.4	-1.1
Waist circumference	0.9	3.3	6.2	1.9	2.3	2.4	0.5	1.5	2.5	1.4	2.0	2.2	2.1	1.9	1.6	2.0	1.7	1.8	2.1	1.4	0.7	1.7	1.4
Arm fat percentage (right)	0.9	3.7	8.0	1.9	2.4	2.5	0.3	1.6	2.8	1.4	2.2	2.3	2.2	1.9	1.6	2.1	1.8	2.0	2.3	1.5	0.6	1.8	1.5
Medication: Cholesterol lowering	0.9	1.4	4.3	-1.1	-0.3	-0.1	-1.5	-1.3	0.1	-1.6	-1.5	-0.9	-0.4	-0.5	-0.6	-0.6	-1.0	-1.6	-1.2	-1.5	-1.6	-1.4	-2.1
Medication: Seretide 50 evohaler	0.9	1.1	1.7	-0.9	-1.0	-1.2	-0.9	-1.0	-1.3	-0.9	-0.8	-0.8	-1.2	-1.2	-1.2	-1.2	-1.3	-0.9	-1.0	-1.0	-1.1	-1.0	-0.8
Mean time to correctly identify matches	0.9	1.8	3.1	1.6	1.6	1.8	0.4	1.0	1.6	1.0	1.4	1.4	1.6	1.6	1.4	1.4	1.1	1.3	1.4	1.1	0.9	1.3	1.0
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.0	-1.0	-0.8	-1.1	-0.9	-0.7	-1.1	-1.1	-1.0	-0.9	-1.0	-0.9	-0.9	-0.9	-1.1	-1.1	-1.0	-1.4	-0.7	-1.0	-1.0
Medication: Aspirin	0.9	1.2	2.8	0.7	1.2	1.5	1.3	0.9	1.6	0.8	0.1	0.2	1.5	1.6	1.7	1.3	1.6	0.4	0.6	0.8	0.8	0.8	-0.0
Supplements: Calcium	0.9	1.0	3.1	-0.9	-0.7	-0.6	-1.8	-0.9	-0.4	-1.4	-0.4	-0.5	-0.8	-1.0	-1.2	-0.9	-1.2	-0.7	-0.6	-1.3	-1.4	-1.0	-0.8
Ulcerative Colitis (UC)	0.8	1.6	3.4	1.5	1.3	0.9	1.8	1.5	0.6	1.5	1.1	1.1	0.8	1.1	1.2	0.9	1.4	1.3	1.1	1.4	1.3	1.4	1.4
Lupus	0.8	1.2	3.1	-1.0	-0.5	-0.9	-0.2	-1.3	-1.2	-0.8	-1.8	-1.4	-0.7	-0.6	-0.6	-0.7	-0.7	-1.5	-1.4	-1.4	-0.4	-1.1	-1.7
Vitamin and mineral supplements	0.8	1.1	2.2	-1.1	-1.5	-1.2	-1.4	-0.8	-1.1	-0.7	-0.7	-1.0	-1.2	-1.3	-1.4	-1.2	-1.1	-0.9	-1.0	-0.6	-0.6	-1.1	-0.8
Father’s age at death	0.8	1.0	1.4	-1.1	-1.0	-1.2	-0.6	-1.0	-1.1	-1.0	-0.8	-1.2	-1.1	-1.2	-1.2	-1.1	-1.0	-0.9	-1.0	-1.1	-0.9	-1.0	-0.8
Commuting to job workplace: Walk	0.8	0.8	2.9	0.7	1.0	0.7	1.5	0.6	0.3	1.2	0.3	-0.2	0.8	1.1	1.2	0.8	1.1	0.6	0.5	0.7	1.7	0.8	0.5
Medication: Blood pressure	0.8	1.6	3.1	1.2	1.3	1.6	0.2	1.0	1.8	1.1	1.3	1.6	1.4	1.2	1.2	1.2	1.2	1.1	1.3	1.7	0.6	1.1	1.0
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	3.1	0.5	0.1	-0.0	0.6	1.5	0.3	1.0	1.6	0.6	-0.2	-0.0	-0.0	0.2	0.8	1.4	1.1	1.1	0.7	1.0	1.8
Allergy	0.7	1.6	3.5	1.3	1.3	1.2	1.7	0.9	0.8	1.4	0.3	0.9	1.6	1.6	1.8	1.6	1.5	0.7	0.9	1.1	1.9	1.2	0.6
Hair/balding pattern: Pattern 3	0.7	1.1	1.7	1.2	1.0	1.3	0.7	0.9	1.3	0.7	1.2	1.1	1.1	1.1	1.1	1.1	0.9	1.2	1.2	0.7	0.4	1.1	1.0
Arm fat mass (right)	0.7	3.0	7.3	1.7	2.2	2.4	0.0	1.4	2.7	1.1	2.0	2.2	2.1	1.7	1.4	1.9	1.5	1.7	2.0	1.3	0.3	1.5	1.2
Length of working week for main job	0.7	0.7	3.4	-1.1	-0.8	-0.3	-1.1	-1.0	0.0	-1.1	-0.4	-0.5	-0.4	-0.7	-0.8	-0.7	-0.8	-0.6	-0.5	-1.1	-1.8	-0.8	-0.8
High blood pressure (siblings)	0.7	1.0	2.3	0.9	0.7	1.3	-0.4	0.6	1.5	0.7	1.5	1.4	1.0	0.8	0.7	0.8	0.8	1.2	1.3	1.1	0.0	0.9	0.9
Wheeze or whistling in the chest in last year	0.7	1.3	3.3	-0.9	-1.1	-1.8	-0.5	-1.1	-1.8	-0.6	-0.6	-1.3	-1.6	-1.6	-1.5	-1.4	-1.2	-0.6	-0.9	-0.8	-0.4	-0.9	-0.3
Illnesses of siblings: Diabetes	0.7	0.8	2.2	1.1	1.3	0.7	1.2	0.0	0.1	1.2	0.3	1.0	1.0	0.9	0.9	0.9	0.8	0.6	0.5	0.9	1.5	0.8	0.5
Long-standing illness, disability or infirmity	0.7	1.1	2.5	-0.8	-0.4	-0.3	-1.5	-1.3	-0.1	-1.3	-1.2	-0.3	-0.6	-0.8	-1.1	-0.8	-1.2	-1.3	-1.1	-1.2	-1.4	-1.2	-1.6
Arm fat mass (left)	0.7	2.9	6.7	1.7	2.2	2.4	0.2	1.4	2.6	1.1	1.9	2.1	2.1	1.8	1.4	2.0	1.5	1.7	2.0	1.1	0.4	1.5	1.1
Guilty feelings	0.7	1.1	2.6	1.1	1.0	0.4	1.6	1.0	-0.1	1.6	0.8	1.0	0.7	0.8	0.9	0.8	1.1	1.0	0.8	1.2	1.6	1.1	1.2
Eye problems/disorders: Glaucoma	0.7	0.9	2.7	0.9	0.8	0.7	0.7	1.2	0.9	1.2	0.8	1.1	0.6	0.7	0.7	0.7	1.0	0.8	0.8	1.6	0.9	0.8	1.0
Hearing difficulty/problems: Yes	0.6	0.9	1.7	0.8	0.7	1.1	0.1	0.7	1.3	0.6	1.3	1.0	1.1	1.0	0.9	0.9	0.7	1.1	1.2	0.8	0.2	1.0	0.9
Pack years adult smoking proportion	0.6	0.9	2.6	0.8	1.0	1.6	0.3	0.7	1.6	-0.0	-0.3	1.0	1.6	1.4	1.2	1.4	0.8	-0.1	0.4	0.0	0.3	0.4	-0.5
Hayfever, allergic rhinitis or eczema	0.6	1.3	2.6	-1.1	-1.0	-1.2	-1.4	-0.8	-0.9	-1.2	-0.3	-0.8	-1.6	-1.5	-1.6	-1.4	-1.3	-0.6	-0.8	-1.0	-1.6	-1.0	-0.5
High blood pressure (mother)	0.6	0.8	2.0	0.7	0.8	1.1	-0.2	0.7	1.2	0.7	1.4	1.4	0.7	0.5	0.3	0.7	0.5	1.1	1.2	1.0	-0.2	0.8	1.0
Body mass index (BMI)	0.6	2.7	5.3	1.6	2.1	2.2	0.5	1.4	2.3	1.2	1.8	2.0	1.9	1.6	1.3	1.9	1.6	1.7	1.9	1.2	0.6	1.6	1.2
Alcohol usually taken with meals	0.6	0.9	2.0	-1.2	-1.4	-0.9	-0.7	-0.8	-0.9	-1.1	-0.5	-1.4	-1.0	-0.9	-0.8	-1.0	-1.0	-0.6	-0.8	-1.3	-1.1	-0.8	-0.6
Medication: Ramipril	0.6	0.8	1.8	0.8	1.2	1.2	0.2	0.5	1.3	0.7	0.8	0.5	1.4	1.3	1.2	1.0	0.9	0.7	0.9	0.3	0.8	0.7	0.3
Illnesses of siblings	0.6	0.9	2.1	-1.0	-1.1	-1.4	-0.2	-0.4	-1.2	-0.6	-0.7	-1.4	-1.3	-1.2	-1.1	-1.0	-0.8	-0.7	-0.9	-0.7	-0.3	-0.7	-0.3
Weight	0.6	3.2	6.8	1.8	2.3	2.4	0.3	1.5	2.6	1.3	1.8	2.4	2.1	1.8	1.4	2.0	1.6	1.7	2.0	1.5	0.6	1.6	1.2
Falls in the last year	0.6	0.8	4.2	0.6	1.2	1.5	-1.2	-0.0	2.0	-0.3	0.6	1.1	1.3	0.8	0.5	0.9	0.4	0.3	0.7	0.2	-0.7	0.2	-0.3
Hair/balding pattern: Pattern 4	0.6	1.4	2.3	-1.4	-1.4	-1.3	-1.0	-0.8	-1.2	-1.0	-1.3	-1.5	-1.3	-1.3	-1.2	-1.2	-1.0	-1.3	-1.3	-1.0	-0.4	-1.3	-1.2
Comparative body size at age 10	0.6	1.6	2.8	1.4	0.9	0.9	1.0	1.1	0.8	1.5	1.4	1.7	1.2	1.0	1.0	1.3	1.0	1.4	1.5	1.6	1.2	1.4	1.6
Eye problems/disorders: None of the above	0.6	0.7	2.2	-0.8	-0.4	-0.1	-1.5	-0.8	0.4	-1.4	-0.7	-0.3	-0.1	-0.7	-0.9	-0.5	-0.8	-0.9	-0.6	-1.2	-1.4	-0.9	-1.1
Medication: Allopurinol	0.6	0.7	3.5	0.5	1.0	1.6	0.3	0.5	1.9	-0.2	-0.3	1.1	1.2	1.0	0.8	1.2	0.7	-0.1	0.3	0.5	-0.6	0.3	-0.5
Heart disease (mother)	0.6	0.7	2.3	-1.0	-0.5	-0.4	-1.1	-0.9	-0.0	-1.0	-0.8	-0.6	-0.7	-0.8	-1.0	-0.9	-0.8	-0.9	-0.8	-0.6	-1.5	-1.0	-1.0
Comparative height size at age 10	0.6	3.2	6.4	1.8	2.1	2.4	0.8	1.7	2.5	1.2	1.1	2.3	2.3	2.1	2.0	2.0	1.8	1.2	1.6	1.7	1.2	1.5	0.9
Age at last live birth	0.6	0.9	1.8	-1.1	-0.5	-1.0	0.1	-1.1	-1.1	-0.5	-1.3	-1.3	-1.0	-0.9	-0.8	-0.8	-0.6	-1.1	-1.1	-0.9	-0.3	-0.9	-1.1
Leg pain on walking	0.6	0.8	2.4	0.8	0.5	0.0	0.9	0.8	-0.2	1.3	1.4	0.3	0.1	0.3	0.3	0.5	0.6	1.3	1.1	0.9	1.2	1.0	1.5
Ever used hormone-replacement therapy (HRT)	0.5	0.7	2.2	0.8	1.1	1.2	-0.1	0.5	1.5	0.5	0.9	1.0	1.0	0.9	0.8	0.8	0.7	0.7	0.9	1.0	-0.2	0.6	0.5
Relative age voice broke	0.5	0.7	2.3	-0.8	-0.7	-1.2	-0.2	-0.7	-1.5	-0.2	-0.8	-0.9	-1.3	-0.9	-0.9	-1.1	-0.8	-0.7	-1.0	-0.6	-0.2	-0.8	-0.6
Serious illness, injury or assault to yourself	0.5	0.6	1.7	-0.8	-0.5	-0.4	-0.9	-1.3	-0.3	-0.8	-0.9	-0.8	-0.5	-0.8	-0.9	-0.6	-0.7	-1.0	-0.8	-0.6	-0.6	-0.9	-1.1
Hearing difficulty/problems with background noise	0.5	0.8	1.8	-0.8	-0.7	-1.1	-0.4	-1.1	-1.3	-0.5	-1.0	-0.9	-1.0	-0.9	-0.8	-0.9	-0.9	-0.9	-1.0	-0.8	-0.2	-0.9	-0.9
Financial difficulties in last 2 years	0.5	0.6	2.8	0.6	1.2	1.4	-0.2	0.4	1.7	-0.1	0.5	0.8	1.1	0.9	0.6	0.9	0.5	0.4	0.7	-0.0	-0.7	0.4	-0.2
Hip circumference	0.5	2.0	4.1	1.4	2.0	1.9	0.2	1.1	2.0	1.0	1.6	1.8	1.6	1.4	1.1	1.6	1.2	1.5	1.7	1.1	0.5	1.3	1.0
Pulse rate	0.5	0.8	3.0	-0.8	-1.1	-0.5	-1.7	-1.1	-0.3	-1.0	-0.6	0.0	-0.5	-0.9	-1.0	-0.7	-1.2	-0.9	-0.7	-0.5	-1.4	-1.0	-0.9
Medication: Lansoprazole	0.5	0.6	1.2	-0.8	-0.9	-0.8	-0.0	-0.7	-0.8	-0.7	-1.0	-1.1	-0.9	-0.6	-0.5	-0.8	-0.5	-0.8	-0.9	-0.7	-0.3	-0.7	-0.7
Health satisfaction	0.5	0.6	1.7	-0.6	-0.0	-0.6	-0.2	-1.3	-1.0	-0.4	-1.3	-0.7	-0.6	-0.5	-0.6	-0.5	-0.6	-1.1	-1.0	-0.7	0.2	-0.8	-1.1
Alcohol intake frequency.	0.5	1.2	2.3	-1.2	-1.3	-1.5	-1.4	-0.9	-1.4	-0.6	-0.1	-1.5	-1.4	-1.4	-1.4	-1.4	-1.2	-0.4	-0.6	-1.0	-0.1	-0.9	-0.2
Eye problems/disorders: Cataract	0.5	0.6	2.2	0.7	0.4	-0.1	1.5	0.4	-0.4	1.3	0.6	0.4	0.1	0.4	0.6	0.2	0.6	0.8	0.5	1.2	1.1	0.8	1.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.4	0.9	0.6	0.4	1.1	1.2	0.1	1.2	1.0	0.8	0.5	0.8	0.9	0.6	0.8	1.0	0.9	0.9	0.9	1.0	1.2
Number of self-reported non-cancer illnesses	0.5	0.8	3.5	0.9	0.9	1.3	-0.4	0.6	1.9	0.3	1.1	0.9	1.2	0.8	0.5	0.9	0.7	0.9	1.1	0.6	0.1	0.7	0.5
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.3	0.8	0.6	0.2	1.1	1.1	0.2	0.9	0.9	0.7	0.4	0.6	0.6	0.6	0.7	1.0	0.8	0.5	0.7	0.9	1.1
Commuting to job workplace: Public transport	0.5	0.5	2.4	0.7	0.5	0.4	0.5	0.5	0.3	1.1	1.0	0.8	0.3	0.3	0.3	0.1	0.7	0.9	0.7	1.6	0.7	0.7	1.1
Commuting to job workplace: Cycle	0.5	0.6	1.0	-0.9	-0.7	-0.7	-0.5	-0.8	-0.7	-0.6	-1.0	-0.6	-0.7	-0.5	-0.3	-0.7	-0.7	-1.0	-1.0	-0.6	-0.8	-0.9	-1.0
Depressed Affect (Nagel 2018)	0.4	0.9	1.8	1.1	1.2	1.1	0.4	0.7	0.9	0.9	1.0	1.3	1.1	1.1	0.9	1.2	0.8	1.0	1.2	0.7	0.5	1.0	0.8
Bipolar Disorder (2011)	0.4	0.4	0.7	0.5	0.3	0.6	0.1	0.4	0.5	0.6	0.8	0.6	0.7	0.6	0.5	0.7	0.4	0.7	0.8	0.7	0.6	0.6	0.6
Primary Biliary Cirrhosis	0.4	0.6	2.8	-0.7	-1.0	-1.3	0.1	-0.5	-1.7	-0.0	-0.5	-0.7	-1.2	-0.9	-0.8	-0.9	-0.7	-0.5	-0.7	-0.4	-0.1	-0.5	-0.1
Ulcerative Colitis	0.4	0.5	1.7	0.8	0.3	-0.2	1.2	0.8	-0.5	1.1	0.8	0.3	-0.3	0.2	0.3	-0.2	0.4	0.9	0.4	0.9	0.8	0.7	1.3
Systolic Blood Pressure	0.4	1.8	6.7	1.4	1.6	2.0	-0.4	1.2	2.6	0.3	1.2	1.9	1.7	1.2	0.8	1.6	1.0	1.0	1.5	1.0	-0.0	1.0	0.6
Respiratory disease	0.4	1.0	1.7	-0.9	-1.1	-1.2	-0.9	-0.6	-1.1	-0.9	-0.6	-0.8	-1.3	-1.2	-1.2	-1.3	-1.1	-0.8	-1.0	-0.7	-0.8	-1.0	-0.5
Chronotype (morning person)	0.4	0.8	3.4	0.8	1.3	1.4	-0.7	0.5	1.9	0.1	0.5	1.6	1.2	0.8	0.6	0.9	0.6	0.3	0.7	0.7	-0.4	0.4	0.0
Relative age of first facial hair	0.4	0.8	2.3	-0.7	-0.6	-1.3	-0.5	-1.0	-1.5	-0.3	-0.6	-0.7	-1.1	-1.1	-1.2	-0.9	-0.9	-0.5	-0.7	-0.9	-0.3	-0.7	-0.5
Maternal smoking around birth	0.4	0.6	1.5	0.9	1.1	1.2	0.1	0.5	1.2	0.1	0.8	1.2	0.8	0.7	0.5	0.9	0.5	0.8	0.9	0.1	-0.5	0.6	0.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	0.8	-0.7	-0.3	-0.7	-0.2	-0.6	-0.6	-0.5	-0.9	-0.9	-0.9	-0.9	-0.9	-0.8	-0.5	-0.8	-0.9	-0.2	-0.3	-0.8	-0.7
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.1	-0.8	-1.0	-1.0	-1.0	-0.5	-0.7	-0.6	-0.3	-0.5	-1.0	-1.0	-1.1	-0.9	-0.8	-0.5	-0.6	-0.4	-0.8	-0.7	-0.4
Medication: Simvastatin	0.4	0.6	1.1	-0.8	-0.5	-0.6	-0.6	-0.9	-0.5	-0.8	-1.0	-0.9	-0.6	-0.6	-0.5	-0.8	-0.7	-1.0	-1.0	-0.5	-0.8	-0.9	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.3	0.9	0.8	0.7	0.6	0.4	0.4	1.0	0.6	0.9	0.8	0.8	0.7	0.9	0.7	0.7	0.8	0.6	1.1	0.8	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.4	0.8	1.0	1.2	0.5	0.4	1.1	0.5	0.6	0.8	1.0	0.8	0.7	1.0	0.7	0.7	0.8	0.6	0.3	0.7	0.4
Had major operations	0.4	0.5	1.0	-0.6	-0.6	-1.0	-0.4	-0.8	-1.0	-0.5	-0.6	-0.8	-0.9	-0.9	-1.0	-0.8	-0.8	-0.5	-0.7	-0.7	-0.1	-0.7	-0.4
Medication: Aspirin	0.4	0.5	1.3	0.1	0.8	1.0	0.8	0.3	1.1	0.2	-0.6	-0.3	1.0	1.1	1.1	0.8	1.0	-0.3	-0.1	0.2	0.3	0.2	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.6	-0.9	-0.9	-0.9	-1.1	-1.1	-0.9	-0.9	-0.8	-0.2	-1.0	-1.1	-1.2	-0.9	-1.1	-0.9	-0.9	-0.8	-1.3	-1.0	-0.8
Breast cancer (self-reported)	0.4	0.4	1.1	-0.4	-0.4	-0.4	-0.2	-0.7	-0.7	-0.8	-1.1	-0.4	-0.5	-0.3	-0.3	-0.6	-0.7	-0.9	-0.9	-1.0	-0.4	-0.7	-0.9
Medication: Lisinopril	0.4	0.5	1.5	-0.1	0.3	0.8	-1.2	-0.8	0.9	-0.9	-0.6	0.2	0.8	0.6	0.4	0.4	-0.4	-0.8	-0.3	-0.8	-0.6	-0.5	-1.2
Risk taking	0.4	0.6	1.0	0.9	0.7	0.9	1.0	0.8	0.5	0.7	0.3	0.9	0.8	1.0	1.0	0.9	0.7	0.5	0.6	0.7	0.6	0.8	0.5
Age started oral contraceptive pill	0.4	0.5	1.4	0.7	0.2	0.4	1.0	0.7	0.2	0.9	0.3	0.7	0.5	0.7	0.9	0.6	0.7	0.5	0.4	1.2	1.0	0.7	0.8
Myopia	0.4	0.6	1.8	-0.8	-0.9	-0.6	-1.1	-0.6	-0.1	-1.0	0.0	-0.5	-0.6	-0.8	-0.9	-0.8	-0.8	-0.3	-0.3	-0.9	-1.4	-0.6	-0.3
Pack years of smoking	0.4	0.7	2.1	0.5	0.9	1.4	-0.1	0.4	1.4	-0.2	-0.4	0.8	1.4	1.2	1.1	1.2	0.6	-0.3	0.2	-0.2	0.1	0.2	-0.7
Major Depression (MDD)	0.3	0.3	1.0	0.6	0.8	0.9	-0.6	0.5	1.0	-0.0	0.8	0.7	0.6	0.7	0.6	0.4	0.2	0.5	0.6	0.2	-0.1	0.4	0.2
Neuroticism (2016)	0.3	0.4	1.0	0.4	0.8	1.0	0.1	0.3	0.8	0.1	0.6	0.9	0.9	0.7	0.6	0.7	0.3	0.6	0.7	-0.0	-0.4	0.5	0.2
Triglycerides	0.3	0.4	2.5	-0.5	-0.7	-0.5	-1.6	-0.4	0.1	-0.5	0.4	0.0	-0.6	-0.9	-1.1	-0.7	-0.7	-0.0	0.0	-0.0	-0.8	-0.4	0.1
Blood Platelet Count	0.3	3.9	8.0	-1.9	-2.3	-2.4	-1.2	-2.1	-2.8	-1.4	-2.1	-2.2	-2.0	-1.9	-1.7	-2.1	-2.0	-2.0	-2.2	-2.0	-0.5	-1.9	-1.8
Allergy or Eczema	0.3	0.9	1.8	-1.0	-1.0	-1.1	-1.0	-0.6	-0.8	-1.0	-0.2	-0.9	-1.4	-1.3	-1.3	-1.2	-1.0	-0.4	-0.6	-0.8	-1.2	-0.8	-0.2
Number of treatments/medications taken	0.3	0.5	2.9	0.5	0.9	1.3	-0.3	0.5	1.7	0.0	0.5	0.7	1.0	0.8	0.6	0.9	0.7	0.4	0.7	0.4	-0.2	0.4	0.0
Medication: Co-codamol	0.3	0.3	1.1	0.3	0.5	0.8	-0.8	-0.4	1.1	-0.3	-0.5	1.0	0.6	0.4	0.2	0.5	0.0	-0.5	-0.1	0.2	-0.6	-0.2	-0.8
Forced vital capacity (FVC)	0.3	1.1	2.4	-0.9	-0.8	-0.6	-1.5	-1.3	-0.4	-1.2	-1.0	-0.4	-0.6	-0.9	-1.0	-0.8	-1.2	-1.1	-1.0	-1.0	-1.5	-1.2	-1.3
Heart attack	0.3	0.4	1.0	0.1	0.7	0.8	0.3	0.3	1.0	0.1	-0.6	-0.3	0.9	0.8	0.8	0.8	0.8	-0.4	-0.1	0.3	0.7	0.1	-0.8
Number of live births	0.3	0.4	1.1	0.8	0.7	0.5	0.3	0.9	0.6	0.7	0.6	0.9	0.4	0.4	0.4	0.4	0.6	0.6	0.6	1.1	0.6	0.5	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.3	1.0	1.0	1.4	0.3	0.7	1.5	0.7	0.9	1.1	1.2	1.0	0.9	1.0	0.9	0.9	1.0	0.9	0.2	0.8	0.6
Birth weight of first child	0.3	0.6	3.2	-0.0	0.4	0.9	-1.6	-0.3	1.4	-0.8	0.5	1.0	0.5	0.0	-0.2	0.3	-0.3	0.1	0.5	-0.3	-1.8	-0.1	-0.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.1	0.6	0.4	0.7	1.1	0.9	0.6	0.6	-0.3	0.2	0.7	1.0	1.1	0.7	0.8	0.0	0.1	0.5	0.9	0.5	-0.0
Gout (self-reported)	0.3	0.4	1.5	-0.1	0.7	1.0	-0.0	0.0	1.2	-0.8	-0.7	0.5	0.7	0.4	0.2	0.7	0.2	-0.5	-0.1	-0.7	-1.1	-0.2	-1.0
Migraine (self-reported)	0.3	0.3	1.1	0.2	0.1	0.9	0.5	0.8	1.1	0.1	0.5	0.6	0.7	0.7	0.7	0.7	0.6	0.5	0.6	0.1	-0.1	0.6	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	2.0	0.3	0.6	0.2	1.4	0.5	-0.2	0.8	0.4	-0.4	0.4	0.7	0.9	0.6	0.7	0.6	0.5	0.0	0.9	0.7	0.5
Pulse rate, automated reading	0.3	0.8	4.2	0.6	0.6	1.5	-0.4	0.7	2.0	-0.1	0.1	1.7	1.3	0.9	0.7	1.1	0.6	0.0	0.5	0.7	-0.6	0.3	-0.2
Chest pain or discomfort	0.3	0.4	1.1	-0.5	-0.3	-0.9	0.6	-0.8	-1.1	-0.0	-1.0	-1.0	-0.7	-0.7	-0.5	-0.6	-0.3	-0.7	-0.9	-0.1	0.1	-0.5	-0.6
Knee pain experienced in last month	0.3	0.5	1.2	-0.5	-0.4	-0.4	-0.3	-0.5	-0.5	-0.9	-1.0	-0.7	-0.6	-0.4	-0.4	-0.6	-0.6	-0.9	-0.9	-1.1	-0.6	-0.8	-1.0
Smoking status: Previous	0.3	0.5	1.3	0.9	1.1	0.8	0.8	0.8	0.5	0.4	0.4	0.9	0.7	0.8	0.7	0.9	0.6	0.6	0.6	0.1	0.5	0.7	0.4
Osteoarthritis (self-reported)	0.3	0.4	1.4	0.6	0.2	0.4	-0.2	0.7	0.5	0.5	1.2	1.0	0.3	0.2	0.1	0.3	0.2	0.9	0.9	0.8	0.3	0.6	1.1
Mother’s age at death	0.3	0.3	1.0	-0.0	-0.4	-0.8	-0.1	0.1	-0.8	0.7	0.8	-0.1	-0.6	-0.7	-0.6	-0.5	-0.1	0.6	0.3	0.9	0.8	0.2	1.0
Medication: Atorvastatin	0.3	0.4	1.7	-0.2	0.5	0.7	-0.6	-0.2	0.8	-0.6	-0.8	-0.2	0.7	0.5	0.3	0.5	0.1	-0.8	-0.3	-0.7	-0.3	-0.4	-1.3
Unable to work because of sickness or disability	0.3	0.4	1.0	0.6	0.8	0.5	0.3	0.4	0.4	1.0	0.6	0.5	0.5	0.4	0.4	0.5	0.6	0.6	0.6	0.7	1.0	0.5	0.6
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.8	-0.6	-0.5	-0.4	-0.4	-0.4	-0.3	-0.7	-0.9	-0.5	-0.5	-0.4	-0.4	-0.5	-0.5	-0.8	-0.8	-0.6	-0.3	-0.6	-0.7
Basal cell carcinoma (self-reported)	0.3	0.3	1.1	0.5	0.1	0.1	0.6	0.4	0.0	0.9	0.7	-0.0	0.1	0.3	0.4	0.1	0.5	0.7	0.5	1.1	0.9	0.6	0.9
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.7	0.1	0.7	0.7	0.4	0.3	0.8	0.2	-0.5	-0.3	0.9	0.8	0.9	0.8	0.8	-0.3	-0.0	0.3	0.9	0.2	-0.6
Crohns Disease (2017)	0.2	0.4	0.9	-0.5	-0.3	-0.5	-0.9	-0.7	-0.4	-0.7	-0.2	-0.9	-0.5	-0.5	-0.6	-0.7	-0.7	-0.4	-0.4	-0.9	-0.5	-0.6	-0.6
Reaction Time	0.2	0.3	0.8	0.8	0.9	0.7	0.1	0.2	0.4	0.6	0.7	0.6	0.6	0.6	0.5	0.5	0.3	0.7	0.6	0.4	0.7	0.5	0.5
Age at First Birth	0.2	0.2	1.1	-0.5	-0.1	-0.5	0.2	-0.3	-0.5	-0.2	-1.0	-0.6	-0.2	-0.1	0.0	-0.2	-0.2	-0.8	-0.8	-0.5	0.0	-0.5	-0.8
Neuroticism	0.2	0.4	1.1	0.6	1.0	0.6	0.7	0.4	0.4	0.7	0.4	0.8	0.7	0.7	0.7	0.9	0.6	0.5	0.6	0.4	0.5	0.6	0.4
Ever had hysterectomy (womb removed)	0.2	0.3	0.9	-0.6	-0.9	-0.6	-0.6	-0.2	-0.3	-0.3	0.4	-0.7	-0.6	-0.6	-0.6	-0.7	-0.5	0.1	-0.0	-0.1	-0.6	-0.2	0.3
Medication for hormone replacement therapy	0.2	0.3	1.3	-0.7	-0.6	-0.3	-0.7	-0.5	0.0	-0.5	0.2	-0.4	-0.5	-0.8	-0.8	-0.6	-0.4	-0.0	-0.1	-0.1	-1.1	-0.4	-0.0
Impedance of leg (right)	0.2	0.9	1.6	-0.9	-0.9	-0.7	-0.7	-0.8	-0.5	-1.1	-1.3	-1.0	-0.8	-0.8	-0.8	-0.8	-0.8	-1.2	-1.1	-0.8	-0.8	-1.1	-1.2
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.8	-0.7	-0.6	-0.4	-0.2	-0.5	-0.3	-0.4	-0.9	-0.6	-0.3	-0.2	-0.1	-0.3	-0.4	-0.8	-0.7	-0.2	-0.4	-0.6	-0.8
Stomach or abdominal pain in last month	0.2	0.2	0.6	0.4	0.5	0.8	-0.2	0.2	0.8	0.1	0.2	0.3	0.7	0.7	0.6	0.7	0.2	0.1	0.4	0.1	0.1	0.2	-0.1
Hair/balding pattern: Pattern 2	0.2	0.2	0.6	0.1	0.5	0.4	0.5	-0.1	0.0	0.3	-0.8	0.2	0.6	0.6	0.7	0.5	0.3	-0.5	-0.3	0.1	0.6	-0.0	-0.7
Had menopause	0.2	0.2	1.2	0.1	0.3	0.7	-0.6	0.2	1.1	-0.2	0.7	0.4	0.5	0.3	0.2	0.3	0.1	0.4	0.6	0.1	-0.7	0.2	0.2
Neuroticism score	0.2	0.5	1.7	0.7	1.3	0.8	0.7	0.2	0.6	0.5	0.3	0.9	0.9	0.7	0.5	1.0	0.6	0.5	0.6	0.2	0.2	0.6	0.1
Worrier / anxious feelings	0.2	0.3	0.9	0.6	0.9	0.6	0.6	0.3	0.5	0.4	0.5	0.6	0.6	0.5	0.4	0.8	0.5	0.6	0.6	0.2	0.2	0.6	0.4
Pulse wave Arterial Stiffness index	0.2	0.2	0.8	0.0	0.4	0.4	-0.2	-0.8	0.3	-0.5	-0.8	0.3	0.5	0.3	0.2	0.3	-0.2	-0.7	-0.4	-0.4	-0.5	-0.4	-0.9
Tense / ‘highly strung’	0.2	0.2	0.9	0.2	0.9	0.6	-0.2	-0.4	0.6	-0.4	-0.5	0.6	0.6	0.3	0.1	0.6	-0.1	-0.4	-0.1	-0.4	-0.7	-0.2	-0.8
Peak expiratory flow (PEF)	0.2	0.5	0.7	-0.5	-0.6	-0.7	-0.7	-0.9	-0.7	-0.5	-0.7	-0.6	-0.8	-0.8	-0.7	-0.8	-0.8	-0.7	-0.8	-0.3	-0.6	-0.8	-0.6
Pulse wave reflection index	0.2	0.2	0.7	-0.3	-0.2	-0.1	-0.0	-0.6	-0.2	-0.7	-0.6	-0.4	-0.2	-0.0	0.0	-0.3	-0.4	-0.5	-0.5	-0.9	-0.7	-0.4	-0.6
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.2	0.3	-0.3	-0.4	0.7	0.6	-0.7	0.9	0.6	0.6	-0.3	-0.1	-0.0	-0.0	0.2	0.6	0.4	0.8	0.7	0.5	1.1
Glaucoma (self-reported)	0.2	0.2	0.7	0.3	0.1	-0.1	0.9	0.6	-0.4	0.8	0.0	0.2	-0.1	0.2	0.3	0.0	0.3	0.2	-0.0	0.8	0.7	0.3	0.5
Pulse wave peak to peak time	0.2	0.3	1.1	0.2	-0.2	-0.1	0.3	0.9	-0.1	0.7	1.0	-0.0	-0.2	-0.0	-0.0	-0.0	0.4	0.9	0.6	0.6	0.6	0.6	1.0
Shortness of breath walking on level ground	0.2	0.3	0.7	-0.5	-0.1	-0.6	-0.1	-0.8	-0.8	-0.4	-0.1	-0.8	-0.6	-0.6	-0.7	-0.4	-0.6	-0.1	-0.2	-0.7	-0.5	-0.3	-0.2
Neck or shoulder pain in last month	0.2	0.3	1.1	0.4	0.3	-0.2	0.9	0.3	-0.6	1.1	0.4	0.4	0.2	0.3	0.4	0.4	0.4	0.5	0.4	0.4	0.9	0.6	0.7
Medication: Blood pressure	0.2	0.3	1.5	0.2	0.8	0.9	-0.4	0.1	1.2	-0.4	0.0	-0.1	0.8	0.6	0.6	0.5	0.4	-0.1	0.2	-0.3	-0.1	0.0	-0.5
Medication: Ibuprofen	0.2	0.2	0.5	0.5	0.5	0.5	0.3	0.0	0.4	0.4	0.4	0.6	0.6	0.4	0.3	0.7	0.4	0.5	0.6	-0.0	0.1	0.5	0.3
Number of full sisters	0.2	0.2	0.9	-0.0	0.3	0.5	-0.4	-0.8	0.4	-0.4	-0.8	0.4	0.4	0.2	0.1	0.2	-0.3	-0.7	-0.4	-0.3	-0.6	-0.4	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	1.0	0.4	0.1	-0.1	-0.1	-0.3	-0.1	0.5	1.0	0.0	0.2	-0.0	-0.1	0.2	0.0	0.8	0.7	0.1	0.5	0.5	0.8
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	1.0	-0.3	-0.6	-0.9	0.1	0.1	-1.0	0.0	0.2	-0.4	-0.8	-0.6	-0.5	-0.6	-0.3	0.1	-0.1	0.0	0.2	-0.1	0.5
Supplements: Vitamin C	0.2	0.2	1.0	-0.3	-0.6	-0.4	0.5	-0.3	-1.0	-0.3	-0.8	-0.3	-0.2	0.1	0.3	-0.0	-0.4	-0.5	-0.5	-0.8	0.1	-0.2	-0.4
Leg fat-free mass (right)	0.2	1.0	2.2	1.0	1.4	1.5	0.1	0.7	1.5	0.6	0.9	1.5	1.2	1.0	0.8	1.1	0.8	0.9	1.1	0.7	0.3	0.8	0.5
Ever had bowel cancer screening	0.2	0.3	1.5	-0.5	-0.6	-0.2	-0.7	-0.2	-0.2	-0.9	-0.2	-0.1	-0.2	-0.1	-0.2	-0.4	-0.7	-0.4	-0.3	-0.9	-1.2	-0.4	-0.5
Medication for cholesterol	0.2	0.4	1.6	-0.4	-0.5	-0.4	-0.5	-0.4	-0.5	-0.8	-0.8	-0.4	-0.3	-0.3	-0.4	-0.3	-0.7	-0.7	-0.6	-1.3	-0.5	-0.6	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.8	0.3	0.6	0.7	0.1	-0.3	0.6	0.1	0.3	0.6	0.9	0.5	0.4	0.6	0.3	0.3	0.5	-0.1	0.0	0.3	0.1
Illnesses of father: None of the above (group 1)	0.2	0.3	0.8	0.6	0.6	0.5	0.0	0.2	0.4	0.3	0.9	0.4	0.6	0.4	0.3	0.5	0.2	0.8	0.8	0.2	0.2	0.6	0.6
Leg predicted mass (right)	0.2	1.1	2.3	1.0	1.5	1.5	0.1	0.7	1.5	0.7	0.9	1.5	1.3	1.1	0.8	1.2	0.9	0.9	1.1	0.7	0.4	0.9	0.6
Alcohol drinker status: Never	0.2	0.2	0.8	-0.7	-0.9	-0.7	-0.3	-0.3	-0.5	-0.4	0.1	-0.6	-0.5	-0.7	-0.6	-0.5	-0.4	-0.1	-0.2	-0.3	-0.4	-0.3	0.1
Fractured/broken bones in last 5 years	0.2	0.3	1.4	0.5	0.7	0.4	0.3	-0.1	0.4	0.8	0.0	0.3	0.6	0.5	0.5	0.4	0.6	0.1	0.2	0.9	1.2	0.3	0.0
Cholesterol lowering medication	0.2	0.3	1.3	-0.0	-0.1	-0.5	1.0	-0.1	-0.9	0.5	-0.8	-0.8	-0.1	0.2	0.5	-0.1	0.1	-0.5	-0.6	0.2	1.1	-0.1	-0.3
Neuroticism (Nagel 2018)	0.1	0.3	0.8	0.5	0.9	0.6	0.2	0.2	0.5	0.4	0.6	0.9	0.6	0.5	0.4	0.6	0.3	0.6	0.6	0.4	-0.1	0.5	0.4
Irritable Bowel Disease (IBD)	0.1	0.2	0.7	0.6	0.6	0.2	0.8	0.5	-0.1	0.6	0.5	0.1	0.1	0.4	0.4	0.1	0.4	0.6	0.3	0.4	0.6	0.5	0.6
Breast Cancer	0.1	0.2	0.6	0.1	0.8	0.3	-0.0	0.3	0.5	0.5	0.5	0.5	0.3	-0.0	-0.1	0.3	0.5	0.4	0.5	0.6	0.4	0.3	0.5
Ovarian Cancer	0.1	0.2	0.7	0.2	0.7	0.3	0.7	-0.2	0.2	0.1	-0.8	-0.2	0.3	0.2	0.2	0.2	0.4	-0.5	-0.4	0.1	0.5	-0.1	-0.6
Crohns Disease (2012)	0.1	0.1	0.4	0.3	0.4	0.6	-0.4	0.1	0.6	-0.2	0.2	0.2	0.3	0.4	0.3	0.2	0.0	0.1	0.2	-0.1	-0.3	0.1	-0.2
Fasting Glucose	0.1	0.1	0.2	0.4	0.4	0.3	0.2	0.3	0.4	-0.1	-0.3	0.5	0.3	0.4	0.5	0.3	0.2	-0.2	-0.1	0.0	-0.1	0.0	-0.2
HbA1C	0.1	0.2	0.9	0.2	0.4	0.7	0.0	0.2	0.9	-0.0	0.1	0.4	0.7	0.5	0.4	0.5	0.4	0.1	0.3	0.1	-0.1	0.2	-0.0
Rheumatoid Arthritis	0.1	0.2	0.8	0.4	0.3	0.2	0.9	0.6	-0.0	0.5	0.0	0.4	0.2	0.5	0.6	0.3	0.5	0.2	0.1	0.5	0.6	0.4	0.3
Blood White Count	0.1	0.6	2.2	0.6	0.7	1.0	-1.2	0.4	1.5	0.2	1.2	1.2	0.9	0.4	0.1	0.5	0.3	0.7	0.9	0.6	-0.2	0.4	0.6
BMI	0.1	0.4	1.4	0.5	0.9	1.0	-0.3	0.4	1.2	0.4	0.7	0.9	0.9	0.5	0.2	0.9	0.5	0.6	0.9	0.2	-0.1	0.5	0.2
Lung FVC	0.1	0.6	2.0	0.7	0.8	1.2	-0.1	0.4	1.4	-0.0	0.6	1.2	1.0	0.7	0.5	1.0	0.4	0.5	0.8	0.4	-0.7	0.5	0.2
Tanning	0.1	1.8	4.3	1.4	1.6	1.5	2.1	1.3	0.9	1.2	-0.3	1.4	1.6	1.8	1.9	1.6	1.5	0.3	0.5	1.0	1.5	1.0	0.2
Sensitivity / hurt feelings	0.1	0.1	0.5	0.3	0.6	-0.2	0.6	0.1	-0.5	0.4	-0.1	0.1	0.0	0.1	0.1	0.3	0.2	0.1	0.1	-0.1	0.7	0.2	0.1
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.5	0.3	0.7	0.3	0.2	-0.2	0.2	-0.0	-0.6	0.1	0.6	0.5	0.5	0.5	0.1	-0.4	-0.2	-0.2	0.3	-0.0	-0.7
Supplements: Zinc	0.1	0.1	0.6	-0.1	0.3	0.2	0.4	-0.2	-0.1	-0.3	-0.8	-0.2	0.0	0.2	0.1	0.2	0.0	-0.5	-0.4	-0.6	0.1	-0.2	-0.7
Diabetes (mother)	0.1	0.1	0.4	0.4	0.4	0.6	-0.0	-0.2	0.6	0.0	0.0	0.2	0.5	0.4	0.3	0.3	0.2	0.0	0.1	0.2	0.1	0.1	-0.1
Leg fat-free mass (left)	0.1	0.7	1.8	0.7	1.2	1.3	-0.1	0.5	1.3	0.4	0.9	1.3	1.1	0.8	0.6	1.0	0.6	0.8	1.0	0.4	0.0	0.7	0.4
Fed-up feelings	0.1	0.1	0.4	0.4	0.3	0.1	-0.0	0.3	0.2	0.4	0.7	0.6	0.1	0.0	-0.0	0.2	0.2	0.6	0.5	0.4	0.2	0.4	0.6
Supplements: Glucosamine	0.1	0.1	0.3	0.2	0.2	0.3	0.3	0.3	0.3	0.0	0.4	0.5	0.2	0.2	0.1	0.3	0.3	0.4	0.4	0.1	-0.2	0.4	0.4
Medication: Levothyroxine sodium	0.1	0.1	0.4	-0.1	0.0	0.5	-0.6	-0.3	0.6	-0.1	0.2	0.2	0.4	0.2	0.0	0.3	-0.1	0.1	0.3	0.1	-0.4	0.0	-0.2
Sitting height	0.1	0.6	1.6	0.9	1.2	1.0	0.4	0.5	0.9	0.5	-0.1	1.3	1.0	0.9	0.9	0.9	0.7	0.1	0.3	0.5	0.9	0.4	0.0
Leg predicted mass (left)	0.1	0.7	1.9	0.8	1.2	1.3	-0.2	0.5	1.4	0.4	0.9	1.3	1.1	0.8	0.6	1.0	0.6	0.8	1.0	0.4	0.0	0.7	0.4
Nervous feelings	0.1	0.2	0.6	-0.4	-0.1	-0.2	-0.7	-0.6	0.0	-0.4	0.0	-0.1	-0.3	-0.6	-0.7	-0.4	-0.4	-0.1	-0.1	0.0	-0.8	-0.3	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	0.4	0.4	0.5	0.7	0.2	0.1	0.4	-0.4	0.6	0.5	0.6	0.6	0.5	0.3	-0.1	-0.0	0.4	0.4	0.2	-0.1
Had other major operations	0.1	0.1	0.5	-0.0	-0.2	-0.5	0.2	-0.2	-0.7	0.0	-0.7	-0.2	-0.4	-0.4	-0.5	-0.2	-0.3	-0.4	-0.5	-0.2	0.4	-0.3	-0.3
Alcohol intake versus 10 years previously	0.1	0.2	0.5	0.2	0.0	0.1	0.1	0.6	0.3	0.4	0.6	0.6	-0.2	-0.1	-0.3	-0.0	0.2	0.6	0.4	0.6	-0.1	0.3	0.7
Happiness	0.1	0.1	0.5	-0.2	-0.2	0.0	-0.4	-0.7	-0.1	-0.4	-0.4	0.2	-0.1	-0.2	-0.3	-0.1	-0.4	-0.4	-0.3	-0.3	-0.4	-0.3	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.7	0.1	-0.1	0.5	-0.4	0.2	0.8	-0.0	0.1	0.5	0.3	0.2	0.0	0.2	0.2	0.1	0.2	0.3	-0.5	0.1	-0.1
Depression (self-reported)	0.1	0.2	0.5	0.5	0.3	0.1	0.5	0.4	-0.0	0.4	0.6	0.2	0.2	0.3	0.3	0.1	0.3	0.6	0.4	0.3	0.7	0.5	0.7
Impedance of arm (left)	0.1	0.2	0.5	0.6	0.5	0.4	0.6	0.3	0.4	0.5	0.3	0.4	0.4	0.5	0.6	0.4	0.6	0.4	0.4	0.7	0.6	0.5	0.4
Breastfed as a baby	0.1	0.1	1.0	-0.1	-0.3	-0.7	0.2	-0.3	-1.0	0.0	-0.2	-0.1	-0.5	-0.3	-0.2	-0.3	-0.5	-0.1	-0.2	-0.3	-0.0	-0.1	0.1
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.4	-0.5	-0.4	-0.1	-0.6	-0.5	0.1	-0.1	0.2	-0.6	-0.1	-0.2	-0.3	-0.3	-0.3	-0.0	-0.0	-0.1	-0.3	-0.2	-0.1
Loud music exposure frequency	0.1	0.1	0.7	-0.4	-0.4	-0.2	-0.1	-0.6	-0.2	-0.1	-0.4	-0.8	-0.3	-0.4	-0.5	-0.3	-0.1	-0.3	-0.3	-0.1	0.1	-0.3	-0.4
Medication: Paracetamol	0.1	0.2	0.8	0.3	-0.1	-0.2	-0.1	-0.0	-0.2	0.5	0.9	0.5	-0.2	-0.2	-0.2	-0.1	-0.0	0.7	0.5	0.6	0.1	0.4	0.9
Medication: Amlodipine	0.1	0.1	0.4	-0.0	0.4	0.5	-0.1	-0.1	0.6	-0.2	-0.4	-0.0	0.5	0.4	0.2	0.4	0.1	-0.3	-0.1	-0.4	-0.2	-0.1	-0.6
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.4	0.0	0.1	-0.5	0.6	0.5	-0.6	0.5	0.3	-0.3	-0.5	-0.2	-0.1	-0.3	0.1	0.3	0.0	0.3	0.4	0.2	0.6
Arm fat-free mass (right)	0.1	0.4	1.2	0.6	0.9	1.1	-0.1	0.4	1.1	0.2	0.4	1.0	0.9	0.7	0.5	0.8	0.4	0.4	0.6	0.2	-0.0	0.4	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.8	0.0	0.2	0.6	-0.9	-0.3	0.8	-0.6	0.1	0.8	0.4	0.0	-0.2	0.2	-0.2	-0.1	0.2	-0.2	-0.7	-0.1	-0.2
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.4	-0.1	-0.3	-0.5	0.1	0.1	-0.6	0.2	0.0	-0.0	-0.4	-0.3	-0.2	-0.3	-0.1	0.0	-0.1	0.0	0.3	-0.0	0.2
Emphysema/chronic bronchitis	0.1	0.1	0.7	-0.1	-0.3	-0.2	-0.2	0.2	-0.1	0.4	0.8	-0.2	-0.3	-0.3	-0.3	-0.3	-0.0	0.6	0.4	0.5	0.1	0.2	0.7
Medication: Omeprazole	0.1	0.1	0.2	-0.2	-0.2	-0.2	-0.3	-0.4	-0.2	-0.2	-0.4	0.0	-0.2	-0.1	-0.2	-0.2	-0.4	-0.4	-0.4	-0.3	-0.1	-0.3	-0.4
Arm predicted mass (right)	0.1	0.7	1.8	0.8	1.2	1.3	0.2	0.7	1.3	0.4	0.5	1.3	1.1	1.0	0.8	1.1	0.7	0.6	0.8	0.5	0.2	0.7	0.3
Loneliness, isolation	0.1	0.1	0.4	-0.0	-0.0	0.2	-0.6	-0.4	0.1	-0.4	0.0	0.6	0.2	0.1	0.0	-0.0	-0.4	-0.1	0.0	-0.2	-0.6	-0.1	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.4	0.3	0.6	0.3	-0.1	-0.3	0.1	-0.1	-0.4	0.2	0.1	0.3	0.2	0.1	-0.1	-0.3	-0.2	-0.2	-0.2	-0.2	-0.5
Medication: Gliclazide	0.1	0.2	0.6	-0.4	0.1	-0.0	0.1	-0.5	-0.0	-0.3	-0.8	-0.5	-0.1	-0.1	-0.1	-0.2	-0.0	-0.6	-0.6	-0.5	-0.2	-0.4	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.9	-0.3	-0.5	-0.3	0.1	-0.5	-0.5	-0.2	-0.9	-0.3	0.0	-0.0	-0.0	0.0	-0.3	-0.7	-0.6	-0.6	-0.0	-0.4	-0.8
Average weekly champagne plus white wine intake	0.1	0.2	0.9	0.0	0.0	-0.6	0.9	0.0	-0.9	0.4	-0.1	-0.5	-0.4	-0.2	-0.1	-0.2	0.1	0.1	-0.1	-0.2	0.5	0.1	0.3
Miserableness	0.1	0.2	0.4	0.5	0.6	0.1	0.4	0.3	-0.1	0.6	0.5	0.7	0.1	0.2	0.2	0.3	0.2	0.5	0.5	0.3	0.3	0.5	0.5
Hearing aid user	0.1	0.1	0.3	-0.4	-0.2	-0.3	-0.3	-0.2	-0.4	-0.2	-0.3	-0.5	-0.3	-0.2	-0.2	-0.3	-0.2	-0.3	-0.3	-0.6	0.0	-0.3	-0.4
High cholesterol (Self-reported)	0.1	0.2	0.6	-0.3	-0.0	-0.1	0.5	-0.2	-0.3	-0.0	-0.8	-0.8	0.1	0.3	0.5	-0.0	0.1	-0.6	-0.5	-0.3	0.2	-0.3	-0.7
Illnesses of father: High blood pressure	0.1	0.1	0.4	-0.2	-0.6	-0.6	0.0	-0.1	-0.6	0.3	0.1	-0.4	-0.5	-0.3	-0.2	-0.6	-0.0	0.0	-0.2	0.2	0.6	-0.1	0.4
Basal metabolic rate	0.1	0.5	1.4	0.6	1.0	1.1	-0.3	0.4	1.2	0.3	0.6	1.2	0.9	0.7	0.4	0.8	0.4	0.5	0.7	0.3	-0.1	0.5	0.3
Irritability	0.1	0.2	1.2	0.3	0.9	0.6	0.4	-0.2	0.5	0.2	-0.4	1.1	0.7	0.4	0.3	0.8	0.3	-0.1	0.1	-0.1	-0.4	0.1	-0.4
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.4	-0.4	-0.4	-0.4	0.1	0.3	-0.4	-0.1	0.4	-0.1	-0.5	-0.3	-0.2	-0.4	-0.2	0.3	0.1	-0.2	-0.6	0.1	0.5
Pain experienced in last month	0.1	0.1	0.3	-0.4	-0.4	-0.2	-0.5	-0.2	0.0	-0.2	0.0	-0.1	-0.2	-0.4	-0.3	-0.4	-0.3	-0.2	-0.2	0.3	-0.5	-0.3	-0.0
Heart disease (siblings)	0.1	0.1	0.4	-0.2	-0.2	-0.1	-0.0	-0.0	-0.4	-0.2	-0.6	-0.1	-0.2	0.1	0.2	-0.2	-0.3	-0.5	-0.5	-0.5	-0.3	-0.3	-0.6
Arm predicted mass (left)	0.1	0.3	1.2	0.5	0.8	1.0	-0.3	0.4	1.1	0.1	0.5	1.0	0.7	0.6	0.3	0.7	0.3	0.4	0.6	0.2	-0.1	0.4	0.1
Worry (Nagel 2018)	0.0	0.1	0.5	0.1	0.5	0.5	-0.1	-0.2	0.7	-0.3	-0.0	0.4	0.3	0.1	-0.1	0.4	0.0	0.0	0.2	-0.1	-0.7	0.0	-0.2
Body Mass Index (BMI) (2010)	0.0	0.0	0.2	-0.3	-0.3	-0.1	-0.3	0.0	0.1	-0.1	0.1	-0.1	-0.3	-0.3	-0.3	-0.3	-0.0	-0.0	-0.1	0.2	-0.4	-0.2	0.0
Blood Eosinophil Count	0.0	0.3	2.1	-0.3	-0.2	-0.8	0.6	-0.2	-1.4	0.1	-0.8	-0.4	-0.6	-0.3	-0.2	-0.3	-0.4	-0.5	-0.6	-0.4	0.3	-0.3	-0.3
Height	0.0	0.2	1.1	0.1	0.2	0.5	-1.1	0.2	0.9	-0.4	0.3	0.8	0.1	-0.1	-0.3	-0.1	-0.1	0.0	0.1	0.4	-0.6	-0.1	0.0
Waist Hip Ratio (WHR)	0.0	0.1	0.4	-0.2	-0.0	-0.0	-0.6	-0.5	0.0	-0.4	-0.1	0.1	0.0	-0.1	-0.2	-0.1	-0.4	-0.2	-0.1	-0.4	-0.4	-0.2	-0.3
Hypothyroidism (self reported)	0.0	0.0	0.1	0.1	-0.2	0.3	0.0	0.2	0.4	-0.0	0.2	0.2	0.4	0.3	0.2	0.4	0.1	0.1	0.3	-0.1	-0.1	0.2	0.1
Hair Pigment	0.0	0.1	1.2	-0.2	0.1	0.4	-1.1	-0.3	0.7	-0.3	0.4	-0.1	0.2	-0.1	-0.2	0.0	-0.1	0.1	0.3	-0.2	-0.5	-0.1	-0.2
Hand grip strength (left)	0.0	0.1	0.2	-0.1	-0.1	0.2	-0.2	-0.1	0.1	-0.3	-0.5	0.1	0.1	0.1	0.0	0.1	-0.2	-0.4	-0.3	-0.3	-0.1	-0.2	-0.5
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.4	0.2	0.2	-0.1	0.3	-0.3	-0.6	0.3	-0.4	0.5	-0.0	0.1	0.1	0.1	-0.2	-0.3	-0.2	-0.0	0.3	-0.1	-0.2
Diabetes (father)	0.0	0.1	0.3	0.1	-0.1	-0.1	0.3	0.5	-0.1	0.4	-0.3	0.2	-0.0	0.1	0.2	0.0	0.2	-0.2	-0.2	0.5	0.4	-0.0	0.0
Hand grip strength (right)	0.0	0.0	0.1	0.1	-0.2	0.0	0.0	0.3	-0.0	0.0	-0.1	0.4	0.0	0.0	-0.0	0.1	-0.1	-0.1	-0.1	0.1	-0.0	-0.0	0.0
Impedance of leg (left)	0.0	0.2	0.9	-0.3	-0.3	-0.2	-0.2	-0.4	-0.1	-0.5	-1.0	-0.5	-0.3	-0.3	-0.3	-0.3	-0.2	-0.8	-0.7	-0.1	-0.1	-0.6	-0.8
Impedance of arm (right)	0.0	0.0	0.1	0.1	-0.0	0.2	-0.3	-0.1	0.4	-0.1	0.1	0.1	0.1	0.1	0.1	-0.0	0.1	0.0	0.0	0.3	-0.1	-0.0	0.0
Trunk fat-free mass	0.0	0.0	0.3	0.0	0.2	0.4	-0.4	0.0	0.4	-0.1	0.2	0.5	0.2	0.1	-0.0	0.1	-0.1	0.1	0.2	-0.1	-0.3	0.0	-0.0
Time employed in main current job	0.0	0.0	0.1	-0.1	-0.0	-0.3	-0.0	0.0	-0.3	0.2	-0.2	0.1	-0.3	-0.2	-0.2	-0.3	-0.1	-0.2	-0.3	0.2	0.0	-0.2	-0.1
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.5	0.2	0.2	0.5	-0.5	-0.1	0.7	-0.0	0.2	0.6	0.4	0.2	0.1	0.2	-0.0	0.1	0.2	0.3	-0.6	0.0	-0.0
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.2	0.0	0.1	-0.0	0.4	-0.1	-0.3	0.1	-0.1	-0.2	-0.0	0.0	-0.0	0.2	0.1	0.0	0.0	-0.4	0.1	0.1	-0.1
Trunk predicted mass	0.0	0.1	0.2	-0.0	0.2	0.3	-0.5	-0.1	0.3	-0.2	0.1	0.5	0.2	0.1	-0.1	0.1	-0.1	-0.0	0.1	-0.2	-0.4	-0.1	-0.1
Standing height	0.0	0.2	1.2	0.4	0.5	0.8	-0.6	0.1	0.9	-0.1	0.1	1.1	0.5	0.4	0.2	0.3	0.2	0.0	0.2	0.5	-0.2	0.1	-0.0
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.1	-0.2	-0.3	-0.0	-0.3	-0.3	0.0	-0.2	0.1	-0.1	0.1	-0.1	-0.2	0.1	-0.2	0.0	0.1	-0.2	-0.3	-0.0	-0.1
Forced vital capacity (FVC), Best measure	0.0	0.1	0.3	0.0	0.2	0.3	-0.5	-0.5	0.3	-0.3	-0.3	0.2	0.3	0.1	0.0	0.2	-0.2	-0.3	-0.1	-0.3	-0.4	-0.2	-0.5
Medication for pain relief, constipation, heartburn	0.0	0.1	0.2	0.1	-0.0	-0.4	-0.2	0.2	-0.3	0.0	0.4	0.2	-0.3	-0.4	-0.5	-0.3	-0.2	0.2	0.1	0.4	0.1	0.0	0.5
Suffer from ‘nerves’	0.0	0.1	0.5	0.1	0.3	0.4	-0.1	-0.7	0.2	-0.3	-0.2	0.3	0.3	0.0	-0.1	0.2	-0.1	-0.1	-0.0	-0.4	-0.3	-0.1	-0.3
Whole body fat-free mass	0.0	0.2	0.6	0.2	0.6	0.7	-0.5	0.1	0.8	-0.1	0.3	0.8	0.5	0.3	0.1	0.4	0.1	0.2	0.4	-0.0	-0.3	0.1	-0.0
Whole body water mass	0.0	0.2	0.6	0.2	0.6	0.7	-0.4	0.2	0.7	0.0	0.4	0.8	0.5	0.3	0.1	0.4	0.1	0.3	0.4	0.0	-0.3	0.2	0.1
Financial situation satisfaction	0.0	0.0	0.1	0.3	0.3	0.0	0.4	-0.3	-0.4	0.3	-0.1	-0.1	-0.1	0.2	0.1	0.1	-0.1	0.0	-0.0	-0.0	0.3	0.1	-0.0
Arm fat-free mass (left)	0.0	0.2	1.1	0.3	0.6	0.9	-0.6	0.2	1.0	-0.2	0.3	0.9	0.6	0.4	0.1	0.6	0.1	0.2	0.5	-0.0	-0.5	0.2	-0.1
Number of operations (self-reported)	0.0	0.1	0.2	-0.3	-0.3	-0.4	-0.2	-0.0	-0.3	-0.0	-0.1	-0.3	-0.3	-0.4	-0.5	-0.3	-0.2	-0.1	-0.1	-0.1	0.1	-0.2	0.1
Impedance of whole body	0.0	0.0	0.1	0.2	0.2	0.2	0.1	-0.0	0.4	-0.1	-0.3	0.1	0.2	0.2	0.2	0.2	0.2	-0.2	-0.1	0.2	0.1	-0.0	-0.2

Hub : Genes

ALMS1P

Models

Trait associations