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chr12:122,713,991-124,591,385

Best TWAS P=2.98e-09 · Best GWAS P=3.1e-09 conditioned to 0.276

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Visceral Omentum	ARL6IP4	0.08	0.02	lasso	5	0.06	3.7e-04	-3.8	-5.3	1.1e-07	-0.82	0.04	0.84	FALSE
2	GTEx	Artery Tibial	ABCB9	0.04	0.02	lasso	2	0.01	3.0e-02	5.9	5.9	3.0e-09	0.93	0.05	0.92	TRUE
3	GTEx	Brain Cerebellar Hemisphere	PITPNM2	0.19	0.15	lasso	1	0.06	1.1e-02	5.2	-5.2	2.2e-07	-0.84	0.04	0.61	FALSE
4	GTEx	Breast Mammary Tissue (Female)	CDK2AP1	0.08	0.03	lasso	3	0.02	6.4e-02	5.1	-5.5	3.7e-08	-0.84	0.07	0.46	FALSE
5	GTEx	Breast Mammary Tissue (Female)	RP11-282O18.3	0.09	0.07	enet	8	0.08	2.8e-03	4.9	-5.4	6.6e-08	-0.82	0.11	0.68	FALSE
6	GTEx	Cells Transformed fibroblasts	OGFOD2	0.10	0.07	lasso	7	0.07	3.1e-06	5.6	5.7	1.5e-08	0.94	0.03	0.97	FALSE
7	GTEx	Cells Transformed fibroblasts	ABCB9	0.08	0.12	enet	7	0.12	4.3e-09	5.9	5.7	1.6e-08	0.96	0.01	0.99	FALSE
8	GTEx	Cells Transformed fibroblasts	ARL6IP4	0.12	0.13	lasso	2	0.12	4.0e-09	5.9	-5.9	4.2e-09	-0.96	0.01	0.99	FALSE
9	GTEx	Colon Sigmoid	ABCB9	0.18	0.16	lasso	6	0.15	4.8e-06	4.8	5.4	7.4e-08	0.86	0.11	0.87	FALSE
10	GTEx	Colon Transverse	ABCB9	0.08	0.07	enet	5	0.09	5.3e-05	4.4	5.4	5.4e-08	0.86	0.05	0.93	FALSE
11	GTEx	Esophagus Mucosa	ABCB9	0.10	0.03	lasso	5	0.05	5.4e-04	4.6	5.3	1.1e-07	0.87	0.06	0.93	FALSE
12	GTEx	Esophagus Muscularis	ABCB9	0.10	0.08	lasso	6	0.05	3.8e-04	4.8	5.2	2.0e-07	0.77	0.16	0.79	FALSE
13	GTEx	Heart Left Ventricle	ABCB9	0.10	0.14	lasso	5	0.10	4.2e-06	5.3	5.2	2.5e-07	0.84	0.04	0.95	FALSE
14	GTEx	Liver	ABCB9	0.32	0.32	lasso	3	0.28	1.9e-08	5.9	5.9	3.0e-09	1.00	0.01	0.99	FALSE
15	GTEx	Lung	ABCB9	0.04	0.02	lasso	3	0.02	8.0e-03	5.1	5.2	1.7e-07	0.85	0.06	0.85	FALSE
16	GTEx	Muscle Skeletal	SETD8	0.16	0.02	lasso	4	0.03	3.8e-04	4.7	5.3	1.3e-07	0.70	0.53	0.35	FALSE
17	GTEx	Pancreas	ARL6IP4	0.07	0.07	lasso	2	0.07	9.6e-04	5.3	-5.3	1.1e-07	-0.83	0.12	0.58	FALSE
18	GTEx	Skin Not Sun Exposed Suprapubic	ABCB9	0.13	0.15	lasso	11	0.11	2.1e-06	5.9	5.6	2.5e-08	0.97	0.02	0.98	FALSE
19	GTEx	Skin Sun Exposed Lower leg	ABCB9	0.09	0.08	lasso	5	0.08	4.3e-07	5.9	5.8	5.4e-09	0.98	0.02	0.98	FALSE
20	GTEx	Testis	MPHOSPH9	0.28	0.27	enet	23	0.32	1.3e-14	4.9	5.6	2.8e-08	0.88	0.11	0.89	FALSE
21	GTEx	Testis	CDK2AP1	0.20	0.14	lasso	5	0.13	2.0e-06	5.4	-5.5	3.7e-08	-0.86	0.05	0.94	FALSE
22	NTR	Blood	ARL6IP4	0.01	0.02	enet	9	0.01	9.8e-06	-3.8	-5.5	3.4e-08	-0.71	0.10	0.85	FALSE
23	NTR	Blood	SBNO1	0.02	0.02	lasso	2	0.02	5.5e-07	5.2	-5.2	1.5e-07	-0.87	0.11	0.89	FALSE
24	YFS	Blood	ARL6IP4	0.02	0.02	enet	12	0.02	2.2e-08	5.8	-5.5	5.0e-08	-0.91	0.02	0.98	FALSE
25	YFS	Blood	MPHOSPH9	0.05	0.07	enet	31	0.07	3.7e-23	5.2	5.3	1.4e-07	0.80	0.32	0.68	FALSE
26	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	OGFOD2	0.03	0.02	blup	16	0.01	5.0e-02	5.9	5.6	1.8e-08	0.99	0.00	0.89	FALSE
27	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ARL6IP4	0.03	0.03	lasso	2	0.02	1.9e-03	5.9	-5.8	5.5e-09	-0.99	0.00	0.94	FALSE
28	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C12orf65	0.05	0.04	blup	34	0.05	1.0e-03	5.2	-5.4	6.1e-08	-0.89	0.01	0.88	FALSE
29	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PITPNM2	0.06	0.07	lasso	5	0.09	1.2e-05	5.1	-5.2	1.7e-07	-0.86	0.07	0.92	FALSE
30	The Cancer Genome Atlas	Brain Lower Grade Glioma	CDK2AP1	0.02	0.01	blup	34	0.02	5.4e-03	5.3	-5.1	2.8e-07	-0.86	0.01	0.82	FALSE
31	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ABCB9	0.19	0.22	enet	9	0.22	7.7e-11	5.9	5.8	7.5e-09	0.98	0.00	1.00	FALSE
32	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ABCB9	0.06	0.06	enet	7	0.07	5.2e-08	5.4	5.8	9.1e-09	0.98	0.01	0.99	FALSE
33	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	OGFOD2	0.02	0.04	lasso	3	0.03	1.3e-04	5.9	5.9	4.0e-09	1.00	0.00	0.97	FALSE
34	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ABCB9	0.17	0.13	enet	6	0.11	3.9e-05	5.9	5.6	2.5e-08	0.90	0.00	0.99	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	ABCB9	0.04	0.05	enet	10	0.05	1.2e-05	5.9	5.7	1.3e-08	0.96	0.01	0.99	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	ARL6IP4	0.03	0.04	blup	17	0.04	1.6e-05	5.5	-5.8	7.7e-09	-0.96	0.01	0.99	FALSE
37	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CDK2AP1	0.13	0.10	blup	34	0.11	8.2e-05	5.4	-5.3	9.4e-08	-0.85	0.02	0.96	FALSE