TWAS hub - SMPD3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Prostate Adenocarcinoma	0.0894	0.0425	0.00011	0.035	0.047	0.057	NA	0.05	0.00012	1.2e-05	1.4e-06	NA	5.9e-06
2	TCGA	Thyroid Carcinoma	0.0320	0.0200	0.00370	0.028	0.018	0.011	NA	0.02	0.00089	6.0e-03	2.9e-02	NA	4.2e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Intelligence (Savage-Jansen 2018)	7.8	23.9	26.8	-5.2	-4.6
Blood Eosinophil Count	6.1	47.2	50.4	6.6	7.1
Chest pain or discomfort	5.7	8.3	13.1	1.9	3.6
Hayfever/allergic rhinitis (self-reported)	5.0	6.6	10.1	1.8	3.2
Smoking status: Previous	3.9	5.8	6.2	2.5	2.4
High cholesterol (Self-reported)	3.9	6.9	12.0	3.5	1.3
Migraine (self-reported)	3.7	4.6	8.4	-1.0	-2.9
Medication: Gliclazide	3.6	4.1	4.1	-2.0	-2.0
Past tobacco smoking	3.5	6.4	9.1	-3.0	-1.9
Wears glasses or contact lenses	3.4	3.9	5.3	-1.6	-2.3
Alcohol drinker status: Never	3.4	4.0	4.9	1.8	2.2
Supplements: Calcium	3.4	3.8	7.3	-0.5	2.7
Mouth/teeth dental problems: Loose teeth	3.2	3.8	4.0	1.9	2.0
Diastolic blood pressure, automated reading	3.2	9.8	12.6	-3.5	-2.7
Trunk fat-free mass	3.1	17.5	22.8	-3.5	-4.8
Basal metabolic rate	3.1	17.0	24.6	-3.1	-5.0
HDL Cholesterol	3.0	5.0	9.5	3.1	0.7
Trunk predicted mass	3.0	17.1	22.0	-3.5	-4.7
Arm predicted mass (right)	3.0	15.3	22.0	-2.9	-4.7
Smoking Status	2.9	7.0	13.4	3.7	0.8
Vitamin and mineral supplements	2.9	3.9	7.3	-0.7	-2.7
Comparative body size at age 10	2.9	8.1	16.2	0.1	-4.0
Whole body fat-free mass	2.9	16.5	22.8	-3.2	-4.8
Whole body water mass	2.9	16.4	22.8	-3.2	-4.8
Arm fat-free mass (left)	2.9	14.6	21.0	-2.9	-4.6
Gout (self-reported)	2.8	3.9	5.1	1.6	2.3
Arm fat-free mass (right)	2.8	14.5	20.9	-2.9	-4.6
Arm predicted mass (left)	2.8	14.1	20.1	-2.8	-4.5
Ulcerative Colitis (UC)	2.7	5.0	6.4	1.9	2.5
Leg fat-free mass (right)	2.7	14.7	22.3	-2.6	-4.7
Leg predicted mass (right)	2.7	14.4	22.0	-2.6	-4.7
Relative age voice broke	2.6	3.9	7.5	-0.6	-2.7
Had major operations	2.6	3.0	5.4	-2.3	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.6	3.0	3.2	1.7	1.8
Risk taking	2.6	3.8	4.9	1.6	2.2
Leg fat-free mass (left)	2.5	13.3	19.7	-2.6	-4.4
Leg predicted mass (left)	2.5	13.4	20.0	-2.6	-4.5
Weight	2.5	12.4	19.7	-2.2	-4.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.3	6.4	2.5	0.4
Qualifications: None of the above	2.4	5.2	6.7	1.9	2.6
Loud music exposure frequency	2.4	2.6	3.1	-1.5	-1.8
Knee pain experienced in last month	2.4	3.8	6.7	2.6	0.9
Ever smoked	2.4	4.1	6.6	2.6	1.3
Cholesterol lowering medication	2.4	3.6	5.3	2.3	1.3
HbA1C	2.3	2.5	4.1	-1.0	-2.0
BMI	2.3	13.1	21.3	-2.2	-4.6
Medication: Atenolol	2.3	2.9	4.5	-1.1	-2.1
Wheeze or whistling in the chest in last year	2.3	4.1	6.1	1.5	2.5
Primary Biliary Cirrhosis	2.2	3.2	4.8	2.2	1.3
Chronotype (morning person)	2.1	4.8	9.5	-3.1	-0.2
Fluid intelligence score	2.1	4.4	4.8	-2.0	-2.2
Forced vital capacity (FVC), Best measure	2.1	7.8	12.3	-3.5	-1.8
Medication: Aspirin	2.1	2.7	4.6	2.1	1.0
Age started oral contraceptive pill	2.1	2.6	4.4	-2.1	-0.9
Medication: Aspirin	2.0	2.7	4.6	2.1	0.8
Schizophrenia (2018)	1.9	4.0	5.2	2.3	1.7
Verbal and Numeric Reasoning (VNR)	1.9	4.5	4.7	-2.0	-2.2
Impedance of leg (right)	1.9	9.4	14.4	2.1	3.8
Forced vital capacity (FVC)	1.9	7.1	10.7	-3.3	-1.9
Qualifications: College or University degree	1.9	6.0	7.1	-2.2	-2.7
Arm fat mass (left)	1.9	7.7	13.6	-1.4	-3.7
Irritability	1.9	3.2	6.2	2.5	0.4
Impedance of whole body	1.9	9.6	14.7	2.1	3.8
Blood Red Count	1.8	17.0	28.2	-2.4	-5.3
Taking other prescription medications	1.8	2.8	3.4	1.8	1.5
Sitting height	1.8	12.5	17.1	-4.1	-2.8
Allergy	1.8	4.0	7.3	-0.9	-2.7
Impedance of arm (right)	1.8	8.3	13.5	1.7	3.7
Hip circumference	1.8	7.9	13.8	-1.4	-3.7
Arm fat mass (right)	1.8	7.2	12.2	-1.5	-3.5
Mouth/teeth dental problems: Bleeding gums	1.8	2.4	4.5	-0.5	-2.1
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.7	4.7	-1.7	-2.2
Crohns Disease (2017)	1.7	3.7	7.4	-2.7	0.0
Waist Hip Ratio (WHR)	1.7	7.7	8.2	2.7	2.9
Allergy or Eczema	1.7	4.6	9.0	0.4	3.0
Hair/balding pattern: Pattern 3	1.7	2.6	4.7	-2.2	-0.6
Qualifications: A levels/AS levels or equivalent	1.7	3.8	6.6	-2.6	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.3	7.5	-2.7	-1.8
Chronic bronchitis/emphysema (mother)	1.7	1.9	2.1	1.5	1.3
Medication for pain relief, constipation, heartburn	1.7	2.9	4.7	-2.2	-1.1
Osteoarthritis (self-reported)	1.7	2.1	4.2	0.3	-2.0
Myopia	1.7	2.5	2.8	-1.7	-1.5
Leg fat mass (left)	1.7	6.7	12.4	-1.0	-3.5
Schizophrenia (2014)	1.6	3.6	5.3	2.3	1.4
Number of incorrect matches in round	1.6	2.6	3.0	1.5	1.7
Medication: Ventolin 100micrograms inhaler	1.6	2.1	4.0	-0.4	2.0
Pain type(s) experienced in last month: Hip pain	1.6	2.1	3.4	1.8	0.8
Ulcerative Colitis	1.5	2.2	2.5	1.4	1.6
Systolic Blood Pressure	1.5	7.4	8.1	-2.8	-2.6
Respiratory disease	1.5	3.4	6.8	0.3	2.6
Systolic blood pressure, automated reading	1.5	4.5	4.7	-2.2	-2.1
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.4	4.1	2.0	-0.8
Father’s age at death	1.5	2.0	2.5	-1.6	-1.2
Ever highly irritable/argumentative for 2 days	1.5	1.8	3.0	1.7	0.7
Worry too long after embarrassment	1.5	2.4	4.1	0.9	2.0
Friendships satisfaction	1.5	1.8	3.6	1.9	0.1
Average weekly champagne plus white wine intake	1.5	2.0	3.9	2.0	-0.4
Body mass index (BMI)	1.4	5.9	10.7	-1.0	-3.3
Impedance of leg (left)	1.4	7.0	10.2	2.0	3.2
Waist circumference	1.4	5.1	9.1	-1.1	-3.0
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	4.2	2.1	0.6
Forced expiratory volume in 1-second (FEV1)	1.4	4.6	6.0	-2.5	-1.8
Impedance of arm (left)	1.4	6.6	10.7	1.6	3.3
Medication: Blood pressure	1.4	2.4	2.8	-1.4	-1.7
Bipolar Disorder or Schizophrenia	1.3	3.2	5.4	2.3	1.0
Age at First Birth	1.3	1.9	2.0	-1.3	-1.4
Body Mass Index (BMI) (2010)	1.3	1.7	3.0	-0.7	-1.7
Medication: Simvastatin	1.3	1.9	3.0	1.7	0.9
Pulse rate	1.3	2.2	2.3	-1.5	-1.4
Exposure to tobacco smoke at home	1.3	1.5	2.6	0.6	1.6
Peak expiratory flow (PEF)	1.3	3.1	4.0	-2.0	-1.5
Pulse wave reflection index	1.3	1.6	2.3	1.5	0.9
Eye problems/disorders: None of the above	1.3	1.5	2.8	-1.7	-0.3
Emphysema/chronic bronchitis	1.3	1.5	2.2	0.8	1.5
Whole body fat mass	1.3	5.4	9.4	-1.2	-3.1
Breast cancer (self-reported)	1.3	1.5	2.8	0.6	1.7
Depression (Nagel 2018)	1.2	1.8	3.6	1.9	-0.2
Alzheimer’s Disease (in mother)	1.2	1.4	1.5	1.2	1.2
Reaction Time	1.2	2.3	3.5	-1.0	-1.9
Fasting Glucose	1.2	1.4	1.9	-1.4	0.9
Average weekly fortified wine intake	1.2	1.4	1.7	-1.3	1.1
Trunk fat mass	1.2	5.2	8.9	-1.2	-3.0
Happiness	1.2	1.5	2.9	0.1	-1.7
Medication: Allopurinol	1.2	1.6	2.0	1.1	1.4
Leg fat mass (right)	1.2	4.8	8.8	-0.9	-3.0
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	2.7	-0.5	-1.6
Smoking status: Current	1.2	1.9	3.9	2.0	-0.0
Ever had prostate specific antigen (PSA) test	1.2	1.4	1.6	1.3	1.1
Bipolar Disorder (2011)	1.1	1.1	1.4	-1.2	-0.8
Height	1.1	22.0	27.0	-4.1	-5.2
Angina	1.1	1.5	2.9	-0.2	1.7
Townsend deprivation index at recruitment	1.1	1.5	2.7	0.6	1.6
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	3.2	1.8	1.0
Financial situation satisfaction	1.1	1.4	1.8	1.3	1.0
Major Depression (MDD)	1.0	1.2	2.3	-0.0	-1.5
Average weekly spirits intake	1.0	1.2	2.2	-0.5	1.5
Current tobacco smoking	1.0	1.6	3.1	1.8	-0.4
Depression (self-reported)	1.0	1.1	2.2	1.5	-0.3
Age at first live birth	1.0	1.8	2.3	-1.5	-1.2
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.3	-1.5	-0.3
Alzheimer’s Disease (in father)	0.9	0.9	1.5	-1.2	-0.6
Hearing difficulty/problems: Yes	0.9	1.3	1.8	1.3	0.9
Medication: Co-codamol	0.9	1.0	1.7	0.6	-1.3
Severe depression (siblings)	0.9	1.0	1.9	1.4	0.4
Multivitamins +/- minerals	0.9	1.1	2.2	-0.2	1.5
Stomach or abdominal pain in last month	0.9	1.1	1.4	-0.9	-1.2
Standing height	0.9	9.2	9.7	-3.1	-3.0
Length of working week for main job	0.9	1.0	1.9	1.4	0.1
Angina (self-reported)	0.9	1.2	2.4	0.0	1.6
Alcohol intake frequency.	0.9	2.1	4.2	2.1	-0.1
Age at last live birth	0.9	1.3	1.5	-1.1	-1.2
Supplements: Vitamin C	0.9	1.1	1.6	0.7	1.3
Hearing aid user	0.9	1.1	1.8	1.3	0.6
Irritable Bowel Disease (IBD)	0.8	1.9	3.7	-0.3	1.9
Coronary Artery Disease (CAD)	0.8	0.9	1.8	-1.4	-0.1
Lung FEV1/FVC ratio	0.8	4.2	7.1	2.7	-1.1
Diabetes (mother)	0.8	1.0	1.5	1.2	0.7
Hand grip strength (right)	0.8	2.2	3.2	-1.1	-1.8
Nervous feelings	0.8	1.4	2.0	0.9	1.4
Hair/balding pattern: Pattern 2	0.8	1.1	1.5	-0.8	-1.2
Had other major operations	0.8	0.9	1.6	0.5	1.3
Tense / ‘highly strung’	0.8	1.3	2.4	1.6	0.5
Birth weight of first child	0.8	1.4	2.5	0.6	1.6
Heart disease (mother)	0.8	1.0	1.5	0.7	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	1.2	-0.9	-1.1
Arm fat percentage (left)	0.8	3.0	5.9	-0.4	-2.4
Asthma (self-reported)	0.8	1.6	3.3	-0.1	1.8
Unable to work because of sickness or disability	0.8	1.1	1.4	-0.9	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.7	1.3	0.6
Neuroticism (Nagel 2018)	0.7	1.6	3.2	1.8	0.2
Lupus	0.7	1.1	1.8	1.4	-0.6
Hypothyroidism (self reported)	0.7	1.7	2.6	1.6	0.9
Relative age of first facial hair	0.7	1.5	2.8	-0.4	-1.7
Qualifications: CSEs or equivalent	0.7	1.0	1.3	1.1	0.8
High blood pressure	0.7	2.1	2.1	-1.4	-1.4
Supplements: Glucosamine	0.7	1.0	1.4	-1.2	0.7
Arm fat percentage (right)	0.7	2.7	5.1	-0.5	-2.2
Asthma	0.7	1.5	2.9	-0.1	1.7
Birth weight	0.7	1.4	2.7	0.4	1.6
Medication: Omeprazole	0.7	0.8	1.7	1.3	-0.0
Hypertension (Self-reported)	0.7	2.0	2.3	-1.5	-1.3
Average weekly red wine intake	0.7	1.0	1.8	-0.5	1.3
Tinnitus: Yes, now most or all of the time	0.7	0.8	0.8	0.9	0.9
Depressed Affect (Nagel 2018)	0.6	1.2	1.4	1.2	-0.9
Mean Putamen Volume	0.6	0.6	1.1	-0.4	1.0
Blood Platelet Count	0.6	6.8	9.7	-2.0	-3.1
Number of treatments/medications taken	0.6	1.0	1.8	1.3	0.6
Medication for hormone replacement therapy	0.6	0.7	1.3	-1.1	0.2
Serious illness, injury or assault to yourself	0.6	0.8	1.0	1.0	-0.8
Hayfever, allergic rhinitis or eczema	0.6	1.3	2.2	0.6	1.5
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.3	1.1	-0.5
Illnesses of mother	0.6	0.7	1.4	-1.2	0.3
Breastfed as a baby	0.6	0.7	1.4	-0.3	1.2
Exposure to tobacco smoke outside home	0.6	0.8	1.5	1.2	0.1
Medication: Ibuprofen	0.6	0.7	1.2	1.1	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	0.9	1.0	-0.6
Loneliness, isolation	0.6	0.8	1.4	1.2	-0.4
Medication for cholesterol	0.6	1.0	1.4	-1.2	-0.8
Guilty feelings	0.6	0.9	1.3	0.7	1.1
Leg fat percentage (left)	0.6	2.3	4.7	-0.1	-2.2
Basal cell carcinoma (self-reported)	0.6	0.7	1.3	-1.2	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	1.9	-0.7	-1.4
Alcohol usually taken with meals	0.5	0.8	1.1	-0.8	-1.0
Noisy workplace	0.5	0.6	0.9	0.5	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	0.8	-0.9	0.6
Mouth/teeth dental problems: Dentures	0.5	0.9	1.7	0.3	1.3
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	0.9	0.7	0.9
Medication: Cholesterol lowering	0.5	0.7	1.5	1.2	0.0
Prospective memory result	0.5	0.6	0.6	0.7	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.2	1.1	0.5
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	1.2	-0.7	-1.1
Glaucoma (self-reported)	0.5	0.5	0.8	0.9	0.5
Health satisfaction	0.5	0.7	1.2	1.1	0.4
Mineral and other dietary supplements	0.5	0.7	1.3	1.2	0.2
Osteoporosis (self-reported)	0.5	0.6	0.9	-0.6	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.2	1.2	-1.0	-1.1
Ever taken oral contraceptive pill	0.5	0.6	0.9	-0.9	0.6
Breast Cancer	0.4	1.0	1.6	-0.7	-1.3
Ovarian Cancer	0.4	0.6	1.2	-1.1	0.1
Blood White Count	0.4	3.0	3.5	1.9	1.6
Lung FVC	0.4	2.3	4.5	-2.1	-0.3
Ever used hormone-replacement therapy (HRT)	0.4	0.6	1.1	-1.0	0.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.9	-0.1	-1.0
High blood pressure (mother)	0.4	0.5	1.0	1.0	-0.0
Hearing difficulty/problems with background noise	0.4	0.6	1.2	1.1	0.2
Pain all over the body in last month	0.4	0.4	0.5	0.6	0.7
Diabetes (self-reported)	0.4	0.6	0.7	-0.7	-0.8
Number of live births	0.4	0.6	1.2	0.1	1.1
Pulse wave Arterial Stiffness index	0.4	0.4	0.7	0.9	-0.3
Blood clot in the leg (DVT)	0.4	0.5	0.8	0.9	0.5
Body fat percentage	0.4	1.5	2.9	-0.1	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.5	-0.7	-0.6
Pulse wave peak to peak time	0.4	0.4	0.8	-0.9	-0.0
Shortness of breath walking on level ground	0.4	0.5	1.0	1.0	0.1
Medication: Seretide 50 evohaler	0.4	0.5	0.7	-0.4	0.9
Overall health rating	0.4	0.8	1.1	1.1	0.7
Illnesses of father: Heart disease	0.4	0.5	0.8	0.5	-0.9
Mood swings	0.4	0.8	1.0	0.8	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.6	0.8	0.5
Qualifications: nursing, teaching	0.4	0.7	1.1	0.5	-1.0
Average weekly beer plus cider intake	0.4	0.6	1.0	-0.5	1.0
Bipolar Disorder (2018)	0.3	0.5	0.7	0.8	-0.5
Schizophrenia vs Biploar Disorder	0.3	0.4	0.8	0.9	-0.2
Worry (Nagel 2018)	0.3	0.5	0.9	0.9	0.5
Alzheimer’s Disease (including proxy)	0.3	0.5	1.0	-0.1	1.0
Crohns Disease (2012)	0.3	0.4	0.5	-0.6	0.7
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.6	-0.8	-0.4
Cardiovascular Disease	0.3	1.0	1.8	0.5	-1.4
Type 2 Diabetes (T2D) (2018)	0.3	0.5	0.6	0.6	-0.8
Neuroticism	0.3	0.6	1.0	1.0	-0.5
Hand grip strength (left)	0.3	0.9	0.9	-1.0	-0.9
Sensitivity / hurt feelings	0.3	0.5	0.7	0.8	-0.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.5	0.7	-0.4
Medication: Metformin	0.3	0.5	0.9	-0.3	-0.9
Diabetes (father)	0.3	0.3	0.6	-0.3	-0.8
Trunk fat percentage	0.3	1.3	2.6	-0.1	-1.6
Age when periods started (menarche)	0.3	0.7	1.5	-1.2	0.1
Chronic bronchitis/emphysema (father)	0.3	0.4	0.6	0.4	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.4	-0.3	-1.2
Neuroticism score	0.3	0.6	1.0	1.0	0.3
Time employed in main current job	0.3	0.3	0.3	-0.6	0.5
Alcohol intake versus 10 years previously	0.3	0.4	0.8	0.2	-0.9
Falls in the last year	0.3	0.4	0.9	0.1	0.9
Lung cancer (father)	0.3	0.4	0.7	-0.4	-0.8
Medication: Paracetamol	0.3	0.5	0.8	0.9	0.3
High blood pressure (siblings)	0.3	0.4	0.6	-0.4	-0.8
Leg fat percentage (right)	0.3	1.2	2.4	0.1	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.4	0.7	0.5
Mean time to correctly identify matches	0.3	0.6	1.0	-0.4	-1.0
Comparative height size at age 10	0.3	1.9	2.8	1.0	-1.7
Suffer from ‘nerves’	0.3	0.4	0.7	0.8	-0.3
Commuting to job workplace: Walk	0.3	0.3	0.5	0.7	0.1
Number of self-reported non-cancer illnesses	0.3	0.5	0.7	0.8	-0.5
Illnesses of father: High blood pressure	0.3	0.3	0.4	-0.6	-0.6
Alcohol drinker status: Previous	0.3	0.3	0.5	0.7	-0.4
Neuroticism (2016)	0.2	0.3	0.4	0.6	0.5
Rheumatoid Arthritis	0.2	0.2	0.4	-0.6	-0.3
Heel T-Score	0.2	1.5	2.9	1.7	-0.4
Pack years adult smoking proportion	0.2	0.3	0.5	0.7	0.3
Maternal smoking around birth	0.2	0.3	0.6	0.7	-0.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	-0.6	-0.1
Medication: Levothyroxine sodium	0.2	0.3	0.4	0.5	0.6
Had menopause	0.2	0.2	0.3	0.4	0.5
Heart attack	0.2	0.2	0.3	0.4	-0.6
Hair/balding pattern: Pattern 4	0.2	0.6	1.1	1.0	-0.3
Headache pain in last month	0.2	0.3	0.4	-0.4	-0.6
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.7	0.3	0.8
Number of full brothers	0.2	0.3	0.5	-0.7	0.3
Number of full sisters	0.2	0.3	0.4	0.6	0.4
Illnesses of father: None of the above (group 1)	0.2	0.3	0.4	-0.7	0.3
Miserableness	0.2	0.3	0.5	0.7	-0.3
Commuting to job workplace: Public transport	0.2	0.3	0.5	0.2	-0.7
Medication: Atorvastatin	0.2	0.2	0.4	0.2	0.6
Fractured/broken bones in last 5 years	0.2	0.3	0.3	-0.4	0.6
Ever depressed for a whole week	0.2	0.3	0.5	0.7	0.2
Commuting to job workplace: Cycle	0.2	0.2	0.4	-0.0	-0.6
Vascular/heart problems diagnosed by doctor	0.2	0.5	0.6	0.6	0.8
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.3	0.6	-0.4
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.2	0.4	-0.5
Heart disease (siblings)	0.2	0.2	0.4	0.1	0.6
Prostate Cancer	0.1	0.2	0.2	-0.4	0.4
LDL Cholesterol	0.1	0.2	0.4	0.6	0.2
Triglycerides	0.1	0.1	0.2	-0.4	-0.2
Tanning	0.1	1.7	2.2	1.1	1.5
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	0.3	-0.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.1	-0.3	-0.3
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.3	-0.4
Supplements: Zinc	0.1	0.1	0.1	0.0	0.3
Fed-up feelings	0.1	0.2	0.4	0.2	-0.7
Financial difficulties in last 2 years	0.1	0.1	0.1	0.3	-0.3
Mouth/teeth dental problems	0.1	0.2	0.3	-0.5	-0.3
Medication: Ramipril	0.1	0.1	0.3	-0.1	-0.5
Illnesses of siblings	0.1	0.2	0.3	-0.6	-0.0
Worrier / anxious feelings	0.1	0.1	0.2	0.4	0.3
Neck or shoulder pain in last month	0.1	0.1	0.1	0.3	-0.3
Pulse rate, automated reading	0.1	0.3	0.5	-0.7	-0.4
Family relationship satisfaction	0.1	0.2	0.3	0.6	0.1
Leg pain on walking	0.1	0.2	0.3	0.5	-0.2
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	0.5	-0.1
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.0	0.5
Ever had bowel cancer screening	0.1	0.1	0.1	0.3	0.2
Diabetes diagnosed by doctor	0.1	0.2	0.3	-0.2	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.2	-0.1	-0.5
Back pain experienced in last month	0.1	0.1	0.2	0.4	0.0
Mother’s age at death	0.1	0.1	0.2	-0.5	0.2
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.2	-0.5
Medication: Blood pressure	0.1	0.2	0.3	0.6	-0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	-0.5	-0.0
Medication: Bendroflumethiazide	0.1	0.2	0.2	0.4	-0.5
Medication: Paracetamol	0.1	0.2	0.4	0.6	-0.2
Medication: Lisinopril	0.1	0.1	0.2	0.1	-0.4
Number of operations (self-reported)	0.1	0.1	0.2	-0.3	0.4
Pain experienced in last month	0.1	0.2	0.3	-0.2	0.5
Pack years of smoking	0.1	0.1	0.2	0.5	0.1
Hair Pigment	0.0	0.3	0.4	0.4	-0.7
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.0	-0.2	-0.0
Medication: Lansoprazole	0.0	0.1	0.1	0.0	-0.3
Medication: Amlodipine	0.0	0.0	0.1	0.0	0.2
Number of children fathered	0.0	0.1	0.1	-0.2	-0.2
Illnesses of siblings: Diabetes	0.0	0.0	0.0	-0.0	-0.0
Long-standing illness, disability or infirmity	0.0	0.1	0.1	-0.3	0.1
Eye problems/disorders: Cataract	0.0	0.0	0.0	0.1	0.1

Hub : Genes

SMPD3

Models

Trait associations